pP01 program activity among Plasma cells

Activation of pP01
pP01 gene program activation in Plasma cells.
Gene program activation of pP01 by different cell subtypes
pP01 gene program activation among cells of different subtypes (Plasma cells).

pP01 top program genes

Top genes of pP01 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pP01 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pP01
pP01 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:306 Ribosome, cytoplasmic 0.000750371857227703 80 10 4 0.4 0.05
CORUM CORUM:308 60S ribosomal subunit, cytoplasmic 0.00206743686878096 47 10 3 0.3 0.0638297872340425
GO:BP GO:0000956 nuclear-transcribed mRNA catabolic process 9.21843630460534e-05 214 10 5 0.5 0.0233644859813084
GO:BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane 0.000112964995768546 96 10 4 0.4 0.0416666666666667
GO:BP GO:0006613 cotranslational protein targeting to membrane 0.000112964995768546 102 10 4 0.4 0.0392156862745098
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 0.0001177747048661 117 10 4 0.4 0.0341880341880342
GO:BP GO:0045047 protein targeting to ER 0.0001177747048661 113 10 4 0.4 0.0353982300884956
GO:BP GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 0.000119994785149185 123 10 4 0.4 0.032520325203252
GO:BP GO:0070972 protein localization to endoplasmic reticulum 0.000204523844228241 146 10 4 0.4 0.0273972602739726
GO:BP GO:0006402 mRNA catabolic process 0.000210400361034798 384 10 5 0.5 0.0130208333333333
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.000274360764256908 3241 10 9 0.9 0.00277692070348658
GO:BP GO:0006401 RNA catabolic process 0.000274360764256908 424 10 5 0.5 0.0117924528301887
GO:BP GO:0010629 negative regulation of gene expression 0.000281458488699083 1460 17 9 0.529411764705882 0.00616438356164384
GO:BP GO:0019083 viral transcription 0.000281458488699083 181 10 4 0.4 0.0220994475138122
GO:BP GO:0006413 translational initiation 0.000339828871436765 201 10 4 0.4 0.0199004975124378
GO:BP GO:0019080 viral gene expression 0.000339828871436765 199 10 4 0.4 0.0201005025125628
GO:BP GO:0009892 negative regulation of metabolic process 0.000339828871436765 3479 10 9 0.9 0.00258695027306697
GO:BP GO:0006612 protein targeting to membrane 0.000339828871436765 204 10 4 0.4 0.0196078431372549
GO:BP GO:0034655 nucleobase-containing compound catabolic process 0.000671397679393385 567 10 5 0.5 0.00881834215167548
GO:BP GO:0072594 establishment of protein localization to organelle 0.000732471073943242 584 10 5 0.5 0.00856164383561644
GO:BP GO:0046700 heterocycle catabolic process 0.000802277768234156 602 10 5 0.5 0.00830564784053156
GO:BP GO:0044270 cellular nitrogen compound catabolic process 0.000802277768234156 608 10 5 0.5 0.00822368421052632
GO:BP GO:0019439 aromatic compound catabolic process 0.000860386930068459 623 10 5 0.5 0.00802568218298555
GO:BP GO:1901361 organic cyclic compound catabolic process 0.00101715023004883 651 10 5 0.5 0.00768049155145929
GO:BP GO:0090150 establishment of protein localization to membrane 0.00201686124983604 351 10 4 0.4 0.0113960113960114
GO:BP GO:0006412 translation 0.00202547929568714 764 10 5 0.5 0.00654450261780105
GO:BP GO:0043043 peptide biosynthetic process 0.00228546105789884 790 10 5 0.5 0.00632911392405063
GO:BP GO:0006886 intracellular protein transport 0.00342813064211196 1186 12 6 0.5 0.00505902192242833
GO:BP GO:0016071 mRNA metabolic process 0.00344205910270505 874 10 5 0.5 0.005720823798627
GO:BP GO:0006605 protein targeting 0.00404383853328077 441 10 4 0.4 0.0090702947845805
GO:BP GO:0048545 response to steroid hormone 0.00415347422426115 349 5 3 0.6 0.00859598853868195
GO:BP GO:0043604 amide biosynthetic process 0.00421579876753427 932 10 5 0.5 0.00536480686695279
GO:BP GO:0006518 peptide metabolic process 0.00458459080692122 955 10 5 0.5 0.00523560209424084
GO:BP GO:0034613 cellular protein localization 0.00524905928050058 2014 12 7 0.583333333333333 0.00347567030784508
GO:BP GO:0070727 cellular macromolecule localization 0.00526069342220149 2024 12 7 0.583333333333333 0.00345849802371542
GO:BP GO:0044265 cellular macromolecule catabolic process 0.00534854882005918 1231 13 6 0.461538461538462 0.00487408610885459
GO:BP GO:0033365 protein localization to organelle 0.00534854882005918 1017 10 5 0.5 0.00491642084562439
GO:BP GO:0045599 negative regulation of fat cell differentiation 0.00567839858509909 55 32 3 0.09375 0.0545454545454545
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.00743204432118543 1853 10 6 0.6 0.0032379924446843
GO:BP GO:0048519 negative regulation of biological process 0.0100237612318078 5757 10 9 0.9 0.00156331422615946
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.0100237612318078 5746 10 9 0.9 0.00156630699617125
GO:BP GO:0009057 macromolecule catabolic process 0.0113477824114832 1468 13 6 0.461538461538462 0.00408719346049046
GO:BP GO:0046483 heterocycle metabolic process 0.0113477824114832 5904 10 9 0.9 0.00152439024390244
GO:BP GO:0043603 cellular amide metabolic process 0.0113477824114832 1241 10 5 0.5 0.0040290088638195
GO:BP GO:0009725 response to hormone 0.0113517908976406 921 35 8 0.228571428571429 0.00868621064060804
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.011413345669515 5956 10 9 0.9 0.00151108126259234
GO:BP GO:0072657 protein localization to membrane 0.011413345669515 665 10 4 0.4 0.00601503759398496
GO:BP GO:0043433 negative regulation of DNA-binding transcription factor activity 0.0121836989111536 187 14 3 0.214285714285714 0.0160427807486631
GO:BP GO:1901575 organic substance catabolic process 0.0134073293943808 2267 13 7 0.538461538461538 0.00308778120864579
GO:BP GO:1901360 organic cyclic compound metabolic process 0.0134073293943808 6201 10 9 0.9 0.00145137880986938
GO:BP GO:0046907 intracellular transport 0.0139168125586721 1767 12 6 0.5 0.0033955857385399
GO:BP GO:0016032 viral process 0.014555086600397 942 14 5 0.357142857142857 0.00530785562632696
GO:BP GO:0016070 RNA metabolic process 0.0156220006968204 4710 10 8 0.8 0.00169851380042463
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.0167967866310971 1001 14 5 0.357142857142857 0.004995004995005
GO:BP GO:0033993 response to lipid 0.0167967866310971 918 9 4 0.444444444444444 0.00435729847494553
GO:BP GO:0034641 cellular nitrogen compound metabolic process 0.0177819845270487 6563 10 9 0.9 0.00137132408959317
GO:BP GO:0015031 protein transport 0.0179675519062552 1929 12 6 0.5 0.0031104199066874
GO:BP GO:0008104 protein localization 0.0179675519062552 2770 12 7 0.583333333333333 0.00252707581227437
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.0179675519062552 6603 10 9 0.9 0.00136301681054066
GO:BP GO:0014070 response to organic cyclic compound 0.0183686218817663 967 9 4 0.444444444444444 0.00413650465356774
GO:BP GO:0051649 establishment of localization in cell 0.0183686218817663 2813 12 7 0.583333333333333 0.00248844649840028
GO:BP GO:0015833 peptide transport 0.0185825639092296 1971 12 6 0.5 0.0030441400304414
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 0.0186063635289583 5017 10 8 0.8 0.00159457843332669
GO:BP GO:0034645 cellular macromolecule biosynthetic process 0.018863974205971 5051 10 8 0.8 0.00158384478321125
GO:BP GO:0042886 amide transport 0.018863974205971 2007 12 6 0.5 0.00298953662182362
GO:BP GO:0045184 establishment of protein localization 0.0195272354118705 2035 12 6 0.5 0.00294840294840295
GO:BP GO:0009059 macromolecule biosynthetic process 0.0195272354118705 5114 10 8 0.8 0.00156433320297223
GO:BP GO:0030218 erythrocyte differentiation 0.0208364644326637 116 32 3 0.09375 0.0258620689655172
GO:BP GO:0010468 regulation of gene expression 0.0212425940200214 5196 10 8 0.8 0.00153964588144727
GO:BP GO:0090304 nucleic acid metabolic process 0.0219239811115361 5226 10 8 0.8 0.00153080750095675
GO:BP GO:0034101 erythrocyte homeostasis 0.0230237997474562 124 32 3 0.09375 0.0241935483870968
GO:BP GO:0009056 catabolic process 0.0230237997474562 2744 13 7 0.538461538461538 0.00255102040816327
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.0241425450808485 549 17 4 0.235294117647059 0.00728597449908925
GO:BP GO:0019222 regulation of metabolic process 0.0245880128279805 7148 10 9 0.9 0.00125909345271405
GO:BP GO:0010033 response to organic substance 0.0254050426612981 3412 17 9 0.529411764705882 0.00263774912075029
GO:BP GO:0032870 cellular response to hormone stimulus 0.0254050426612981 645 15 4 0.266666666666667 0.0062015503875969
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0267224764051541 2255 20 8 0.4 0.00354767184035477
GO:BP GO:0045598 regulation of fat cell differentiation 0.0271478443358769 139 32 3 0.09375 0.0215827338129496
GO:BP GO:0033036 macromolecule localization 0.0274897223454496 3218 12 7 0.583333333333333 0.00217526413921691
GO:BP GO:0071705 nitrogen compound transport 0.0283886688322734 2322 12 6 0.5 0.00258397932816537
GO:BP GO:0006950 response to stress 0.0307641402248241 4170 15 9 0.6 0.00215827338129496
GO:BP GO:0002262 myeloid cell homeostasis 0.0310082820400074 151 32 3 0.09375 0.0198675496688742
GO:BP GO:0071396 cellular response to lipid 0.0310082820400074 578 9 3 0.333333333333333 0.00519031141868512
GO:BP GO:0071407 cellular response to organic cyclic compound 0.0315874229049523 587 9 3 0.333333333333333 0.00511073253833049
GO:BP GO:0070887 cellular response to chemical stimulus 0.033498338464089 3393 15 8 0.533333333333333 0.00235779546124374
GO:BP GO:0032271 regulation of protein polymerization 0.0337601234758725 236 22 3 0.136363636363636 0.0127118644067797
GO:BP GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 0.0342151943137256 760 15 4 0.266666666666667 0.00526315789473684
GO:BP GO:0051641 cellular localization 0.0390198838426463 3541 12 7 0.583333333333333 0.00197684269980232
GO:BP GO:0044248 cellular catabolic process 0.0405468275560322 2347 13 6 0.461538461538462 0.00255645504899872
GO:BP GO:1901700 response to oxygen-containing compound 0.0422741759221664 1739 17 6 0.352941176470588 0.00345025876940771
GO:BP GO:0010942 positive regulation of cell death 0.0422741759221664 684 9 3 0.333333333333333 0.0043859649122807
GO:BP GO:0009719 response to endogenous stimulus 0.0423764302033859 1683 35 9 0.257142857142857 0.0053475935828877
GO:BP GO:0044249 cellular biosynthetic process 0.0423764302033859 6154 10 8 0.8 0.00129996750081248
GO:BP GO:0010467 gene expression 0.0424104839119181 6179 10 8 0.8 0.00129470788153423
GO:BP GO:0071310 cellular response to organic substance 0.0425525576599133 2776 15 7 0.466666666666667 0.00252161383285303
GO:BP GO:0006811 ion transport 0.043076701865806 3661 12 7 0.583333333333333 0.00191204588910134
GO:BP GO:1901576 organic substance biosynthetic process 0.0438309988903541 6248 10 8 0.8 0.00128040973111396
GO:BP GO:0001818 negative regulation of cytokine production 0.0438309988903541 381 32 4 0.125 0.010498687664042
GO:BP GO:0042221 response to chemical 0.0460707992643924 4781 17 10 0.588235294117647 0.00209161263334031
GO:BP GO:0051090 regulation of DNA-binding transcription factor activity 0.0460707992643924 456 14 3 0.214285714285714 0.00657894736842105
GO:BP GO:0009058 biosynthetic process 0.0461827370058062 6340 10 8 0.8 0.00126182965299685
GO:BP GO:0071702 organic substance transport 0.046934243380257 2766 12 6 0.5 0.00216919739696312
GO:BP GO:0045444 fat cell differentiation 0.0471536638928067 229 55 4 0.0727272727272727 0.0174672489082969
GO:BP GO:0051258 protein polymerization 0.0495796760660912 305 22 3 0.136363636363636 0.00983606557377049
GO:BP GO:0044260 cellular macromolecule metabolic process 0.0495796760660912 8390 10 9 0.9 0.00107270560190703
GO:CC GO:0022626 cytosolic ribosome 4.3324009581446e-05 109 10 4 0.4 0.036697247706422
GO:CC GO:0044391 ribosomal subunit 0.000200641868186386 190 10 4 0.4 0.0210526315789474
GO:CC GO:0022625 cytosolic large ribosomal subunit 0.000208110185007462 57 10 3 0.3 0.0526315789473684
GO:CC GO:0005840 ribosome 0.000275462122069246 245 10 4 0.4 0.0163265306122449
GO:CC GO:0015934 large ribosomal subunit 0.00111993420844433 118 10 3 0.3 0.0254237288135593
GO:CC GO:1990904 ribonucleoprotein complex 0.0077648536861388 688 10 4 0.4 0.00581395348837209
GO:CC GO:0005829 cytosol 0.0328713339050528 5303 19 12 0.631578947368421 0.00226287007354328
GO:MF GO:0003735 structural constituent of ribosome 0.00031397330140428 171 10 4 0.4 0.0233918128654971
GO:MF GO:0003723 RNA binding 0.0209780946835393 1943 10 6 0.6 0.00308800823468863
GO:MF GO:0005198 structural molecule activity 0.026007849898617 698 10 4 0.4 0.00573065902578797
GO:MF GO:0000976 transcription regulatory region sequence-specific DNA binding 0.0307642721955145 1507 69 13 0.188405797101449 0.0086264100862641
GO:MF GO:0003700 DNA-binding transcription factor activity 0.0307642721955145 1441 69 13 0.188405797101449 0.00902151283830673
GO:MF GO:0001067 regulatory region nucleic acid binding 0.0307642721955145 1509 69 13 0.188405797101449 0.00861497680583168
GO:MF GO:0000987 cis-regulatory region sequence-specific DNA binding 0.0307642721955145 1209 69 12 0.173913043478261 0.00992555831265509
GO:MF GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 0.0307642721955145 1190 69 12 0.173913043478261 0.0100840336134454
GO:MF GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 0.0307642721955145 1408 69 13 0.188405797101449 0.00923295454545455
GO:MF GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.0359787686724577 1375 69 12 0.173913043478261 0.00872727272727273
GO:MF GO:0140110 transcription regulator activity 0.0359787686724577 1935 69 15 0.217391304347826 0.00775193798449612
GO:MF GO:1990837 sequence-specific double-stranded DNA binding 0.0369287474626707 1570 69 13 0.188405797101449 0.00828025477707006
KEGG KEGG:03010 Ribosome 0.00111097178223299 153 10 4 0.4 0.0261437908496732
KEGG KEGG:05171 Coronavirus disease - COVID-19 0.0027895697414568 231 10 4 0.4 0.0173160173160173
REAC REAC:R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 4.21300639533786e-05 112 10 4 0.4 0.0357142857142857
REAC REAC:R-HSA-192823 Viral mRNA Translation 4.21300639533786e-05 90 10 4 0.4 0.0444444444444444
REAC REAC:R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 4.21300639533786e-05 113 10 4 0.4 0.0353982300884956
REAC REAC:R-HSA-72689 Formation of a pool of free 40S subunits 4.21300639533786e-05 102 10 4 0.4 0.0392156862745098
REAC REAC:R-HSA-72764 Eukaryotic Translation Termination 4.21300639533786e-05 94 10 4 0.4 0.0425531914893617
REAC REAC:R-HSA-72613 Eukaryotic Translation Initiation 4.21300639533786e-05 120 10 4 0.4 0.0333333333333333
REAC REAC:R-HSA-156842 Eukaryotic Translation Elongation 4.21300639533786e-05 94 10 4 0.4 0.0425531914893617
REAC REAC:R-HSA-2408557 Selenocysteine synthesis 4.21300639533786e-05 94 10 4 0.4 0.0425531914893617
REAC REAC:R-HSA-2408522 Selenoamino acid metabolism 4.21300639533786e-05 117 10 4 0.4 0.0341880341880342
REAC REAC:R-HSA-72737 Cap-dependent Translation Initiation 4.21300639533786e-05 120 10 4 0.4 0.0333333333333333
REAC REAC:R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 4.21300639533786e-05 116 10 4 0.4 0.0344827586206897
REAC REAC:R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 4.21300639533786e-05 96 10 4 0.4 0.0416666666666667
REAC REAC:R-HSA-927802 Nonsense-Mediated Decay (NMD) 4.21300639533786e-05 116 10 4 0.4 0.0344827586206897
REAC REAC:R-HSA-156902 Peptide chain elongation 4.21300639533786e-05 90 10 4 0.4 0.0444444444444444
REAC REAC:R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 4.21300639533786e-05 113 10 4 0.4 0.0353982300884956
REAC REAC:R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 4.21300639533786e-05 102 10 4 0.4 0.0392156862745098
REAC REAC:R-HSA-168273 Influenza Viral RNA Transcription and Replication 5.97745643339514e-05 133 10 4 0.4 0.0300751879699248
REAC REAC:R-HSA-168255 Influenza Infection 9.60196974336747e-05 152 10 4 0.4 0.0263157894736842
REAC REAC:R-HSA-9711097 Cellular response to starvation 0.000103433129811807 157 10 4 0.4 0.0254777070063694
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.000137832339318665 171 10 4 0.4 0.0233918128654971
REAC REAC:R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.000171630909085526 183 10 4 0.4 0.0218579234972678
REAC REAC:R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.000202098779554616 193 10 4 0.4 0.0207253886010363
REAC REAC:R-HSA-72312 rRNA processing 0.000235876630592496 203 10 4 0.4 0.0197044334975369
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 0.000293825541037764 217 10 4 0.4 0.0184331797235023
REAC REAC:R-HSA-2262752 Cellular responses to stress 0.000815932683406107 546 16 6 0.375 0.010989010989011
REAC REAC:R-HSA-72766 Translation 0.00086510857692627 292 10 4 0.4 0.0136986301369863
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 0.000869708841838604 560 16 6 0.375 0.0107142857142857
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 0.00196457784379083 368 10 4 0.4 0.0108695652173913
REAC REAC:R-HSA-5663205 Infectious disease 0.00361574926236572 815 10 5 0.5 0.00613496932515337
REAC REAC:R-HSA-422475 Axon guidance 0.00838982129063761 549 10 4 0.4 0.00728597449908925
REAC REAC:R-HSA-9675108 Nervous system development 0.00959321256315082 574 10 4 0.4 0.00696864111498258
REAC REAC:R-HSA-8953854 Metabolism of RNA 0.0149765117257304 658 10 4 0.4 0.0060790273556231
REAC REAC:R-HSA-1643685 Disease 0.0169575847620607 1509 15 7 0.466666666666667 0.0046388336646786
TF TF:M09739_1 Factor: ZGPAT; motif: GRGGCWGNGGNG; match class: 1 0.00362240851488058 2740 73 26 0.356164383561644 0.00948905109489051
TF TF:M09862_1 Factor: ZNF614; motif: NCYCWGCCYYNNN; match class: 1 0.00362240851488058 4193 72 33 0.458333333333333 0.00787025995707131
TF TF:M12184_1 Factor: KLF14; motif: NRCCACGCCCMCN; match class: 1 0.00362240851488058 350 66 9 0.136363636363636 0.0257142857142857
TF TF:M00008_1 Factor: Sp1; motif: GGGGCGGGGT; match class: 1 0.00362240851488058 4937 74 37 0.5 0.00749442981567754
TF TF:M01857_1 Factor: AP-2alpha; motif: NGCCYSNNGSN; match class: 1 0.00362240851488058 4616 64 32 0.5 0.00693240901213172
TF TF:M12313 Factor: ZNF460; motif: NNACNCCCCCCNN 0.00425292325111341 5825 63 36 0.571428571428571 0.00618025751072961
TF TF:M02036_1 Factor: WT1; motif: CGCCCCCNCN; match class: 1 0.00751993489354726 5290 70 36 0.514285714285714 0.00680529300567108
TF TF:M12148_1 Factor: SP8; motif: NCCACGCCCMCN; match class: 1 0.00751993489354726 421 66 9 0.136363636363636 0.0213776722090261
TF TF:M00931_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.00792097379855381 5905 74 40 0.540540540540541 0.00677392040643522
TF TF:M10026_1 Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN; match class: 1 0.00919201518098358 4894 62 31 0.5 0.0063342868818962
TF TF:M07063_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.0131177495761081 3495 70 27 0.385714285714286 0.00772532188841202
TF TF:M10435_1 Factor: Sp2; motif: GGGGCGGGG; match class: 1 0.0131177495761081 3495 70 27 0.385714285714286 0.00772532188841202
TF TF:M08911_1 Factor: CTCF; motif: NCCRSTAGGGGGCGC; match class: 1 0.0131177495761081 3934 66 28 0.424242424242424 0.00711743772241993
TF TF:M00196_1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 0.014921407351973 5919 74 39 0.527027027027027 0.00658895083628991
TF TF:M09974 Factor: BTEB1; motif: GNRGKGGGCGTGGCC 0.0166435742515625 869 61 11 0.180327868852459 0.0126582278481013
TF TF:M09895_1 Factor: E2F-6; motif: NGGGCGGGARRNN; match class: 1 0.0166435742515625 2711 74 23 0.310810810810811 0.00848395426042051
TF TF:M09973_1 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 0.0166435742515625 6607 74 41 0.554054054054054 0.00620553957923415
TF TF:M00189_1 Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 0.0166435742515625 6093 64 35 0.546875 0.005744296733957
TF TF:M07277_1 Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 0.0166435742515625 4149 70 29 0.414285714285714 0.00698963605688118
TF TF:M03923_1 Factor: SP8; motif: RCCACGCCCMCY; match class: 1 0.0166435742515625 401 72 8 0.111111111111111 0.0199501246882793
TF TF:M00986_1 Factor: Churchill; motif: CGGGNN; match class: 1 0.0166435742515625 10357 74 55 0.743243243243243 0.00531041807473207
TF TF:M01858 Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN 0.0166435742515625 7418 74 44 0.594594594594595 0.00593151792936101
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.0166435742515625 6334 74 40 0.540540540540541 0.00631512472371329
TF TF:M12147_1 Factor: SP8; motif: RNCACGCCCMCN; match class: 1 0.0166435742515625 331 66 7 0.106060606060606 0.0211480362537764
TF TF:M12150_1 Factor: SP9; motif: NCCACGCCCMCN; match class: 1 0.0166435742515625 294 51 6 0.117647058823529 0.0204081632653061
TF TF:M10432 Factor: MAZ; motif: GGGMGGGGS 0.0166435742515625 9259 74 51 0.689189189189189 0.00550815422831839
TF TF:M00982_1 Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1 0.0166435742515625 3518 74 27 0.364864864864865 0.00767481523592951
TF TF:M12173_1 Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 0.0166435742515625 4965 70 33 0.471428571428571 0.00664652567975831
TF TF:M01199_1 Factor: RNF96; motif: BCCCGCRGCC; match class: 1 0.0166435742515625 4322 69 30 0.434782608695652 0.00694123091161499
TF TF:M03893_1 Factor: WT1; motif: GNGGGGGCGGGG; match class: 1 0.0166435742515625 3980 63 26 0.412698412698413 0.00653266331658291
TF TF:M12157_1 Factor: KLF15; motif: RCCACGCCCCCC; match class: 1 0.0166435742515625 816 69 11 0.159420289855072 0.0134803921568627
TF TF:M12154 Factor: Sp3; motif: NGCCACGCCCMCN 0.0166435742515625 2190 73 20 0.273972602739726 0.0091324200913242
TF TF:M10071_1 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 0.0166435742515625 4623 73 32 0.438356164383562 0.00692191217823924
TF TF:M01118_1 Factor: WT1; motif: SMCNCCNSC; match class: 1 0.0166435742515625 2766 62 21 0.338709677419355 0.00759219088937093
TF TF:M09910_1 Factor: ER-beta; motif: RGGTCASCNTGMCCY; match class: 1 0.0166435742515625 4079 74 30 0.405405405405405 0.00735474380975729
TF TF:M01873 Factor: Egr-1; motif: GCGGGGGCGG 0.0166435742515625 6738 71 40 0.563380281690141 0.00593647966755714
TF TF:M10529 Factor: Sp1; motif: RGGGMGGRGSNGGGG 0.0166435742515625 6891 70 40 0.571428571428571 0.00580467276157307
TF TF:M10072_1 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 0.0166435742515625 6225 74 40 0.540540540540541 0.00642570281124498
TF TF:M12351_1 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 0.0166435742515625 8180 71 46 0.647887323943662 0.00562347188264059
TF TF:M12140 Factor: Egr-1; motif: NNCRCCCMCGCNN 0.0166435742515625 5360 74 36 0.486486486486487 0.00671641791044776
TF TF:M04148 Factor: TFAP2A; motif: NGCCCYNNGGGCN 0.0168962599550471 10040 73 53 0.726027397260274 0.00527888446215139
TF TF:M00800_1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 0.0168962599550471 4268 63 27 0.428571428571429 0.0063261480787254
TF TF:M12180 Factor: BTEB3; motif: NRCCACGCCCMCN 0.0168962599550471 2088 72 19 0.263888888888889 0.00909961685823755
TF TF:M12182 Factor: BTEB3; motif: NRCCACGCCCMCN 0.0172120206343668 1738 72 17 0.236111111111111 0.00978135788262371
TF TF:M09658_1 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS; match class: 1 0.0192676112175818 2033 63 17 0.26984126984127 0.00836202656173143
TF TF:M00932_1 Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 0.0192676112175818 6047 74 38 0.513513513513513 0.00628410782206053
TF TF:M09826_1 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 0.0192676112175818 7508 70 42 0.6 0.00559403303143314
TF TF:M01858_1 Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN; match class: 1 0.0196445616988741 3141 63 22 0.349206349206349 0.0070041388092964
TF TF:M01973 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC 0.0196445616988741 6167 73 38 0.520547945205479 0.00616182909031944
TF TF:M04515 Factor: E2F-1; motif: WWTGGCGCCAAA 0.0196445616988741 13334 74 64 0.864864864864865 0.0047997600119994
TF TF:M00915_1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 0.0207351302207841 4551 70 30 0.428571428571429 0.00659195781147001
TF TF:M12227_1 Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 0.0219456473208411 5898 74 37 0.5 0.00627331298745337
TF TF:M01655 Factor: p53; motif: GGACATGYYCGGACATGYYC 0.0219456473208411 3419 27 13 0.481481481481481 0.00380228136882129
TF TF:M04148_1 Factor: TFAP2A; motif: NGCCCYNNGGGCN; match class: 1 0.0219456473208411 9613 73 51 0.698630136986301 0.00530531571829814
TF TF:M09896_1 Factor: E2F-7; motif: GRGGCGGGAANNN; match class: 1 0.0219456473208411 4525 74 31 0.418918918918919 0.00685082872928177
TF TF:M12186_1 Factor: BTEB4; motif: NCCACGCCCM; match class: 1 0.0219456473208411 3958 69 27 0.391304347826087 0.00682162708438605
TF TF:M12158_1 Factor: KLF15; motif: NCCMCGCCCMCN; match class: 1 0.0219456473208411 6004 63 33 0.523809523809524 0.00549633577614923
TF TF:M00800 Factor: AP-2; motif: GSCCSCRGGCNRNRNN 0.0219456473208411 9119 64 44 0.6875 0.00482509047044632
TF TF:M12184 Factor: KLF14; motif: NRCCACGCCCMCN 0.0227970699504451 2532 73 21 0.287671232876712 0.00829383886255924
TF TF:M12179_1 Factor: BTEB3; motif: NRCCACGCCCMCN; match class: 1 0.0230059890642662 134 45 4 0.0888888888888889 0.0298507462686567
TF TF:M07354 Factor: Egr-1; motif: GCGGGGGCGG 0.0251779631208726 7801 71 43 0.605633802816901 0.00551211383156006
TF TF:M12153_1 Factor: Sp3; motif: NGCCACGCCCMCN; match class: 1 0.0252303286651235 1938 69 17 0.246376811594203 0.0087719298245614
TF TF:M08877 Factor: EGR3; motif: NCMCRCCCACTNMN 0.0252303286651235 6099 46 26 0.565217391304348 0.00426299393343171
TF TF:M09738_1 Factor: ZNF511; motif: GGRRGRGGCWGNG; match class: 1 0.0252303286651235 4738 75 32 0.426666666666667 0.00675390460109751
TF TF:M12179 Factor: BTEB3; motif: NRCCACGCCCMCN 0.0263681140519381 1350 72 14 0.194444444444444 0.0103703703703704
TF TF:M04811_1 Factor: RelA-p65; motif: BCWGGGRANNK; match class: 1 0.0263681140519381 1834 31 10 0.32258064516129 0.0054525627044711
TF TF:M09970_1 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 0.0263681140519381 3783 70 26 0.371428571428571 0.00687285223367698
TF TF:M06602 Factor: ZNF669; motif: NCGATTTTAWTT 0.0263681140519381 103 26 3 0.115384615384615 0.029126213592233
TF TF:M08246_1 Factor: ER71:C/EBPdelta; motif: NNCGGAWRTTRCGYAAN; match class: 1 0.0263681140519381 2253 10 6 0.6 0.00266311584553928
TF TF:M07354_1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 0.0263681140519381 3561 70 25 0.357142857142857 0.00702049985959
TF TF:M00933_1 Factor: Sp1; motif: CCCCGCCCCN; match class: 1 0.0263681140519381 5166 70 32 0.457142857142857 0.00619434765776229
TF TF:M09603 Factor: Egr-1; motif: NNNNNGYGKGGGNGGGNN 0.0263681140519381 4627 74 31 0.418918918918919 0.00669980548951805
TF TF:M04855_1 Factor: IRF-4; motif: AAGTTTC; match class: 1 0.0267550804732543 2009 15 7 0.466666666666667 0.00348432055749129
TF TF:M05327_1 Factor: WT1; motif: NGCGGGGGGGTSMMCYN; match class: 1 0.0268655269120176 1757 70 16 0.228571428571429 0.00910643141718839
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.0281458216748783 9362 74 50 0.675675675675676 0.00534073915829951
TF TF:M00446_1 Factor: Spz1; motif: DNNGGRGGGWWNNNN; match class: 1 0.0290649111372933 2858 63 20 0.317460317460317 0.00699790062981106
TF TF:M12152_1 Factor: Sp1; motif: NWRGCCACGCCCMCN; match class: 1 0.0290649111372933 2859 63 20 0.317460317460317 0.00699545295557887
TF TF:M01972 Factor: EGR-1; motif: TGCGTGGGCGK 0.0295835350767397 5360 74 34 0.459459459459459 0.00634328358208955
TF TF:M00982 Factor: KROX; motif: CCCGCCCCCRCCCC 0.0308697333611374 7815 74 44 0.594594594594595 0.00563019833653231
TF TF:M01104 Factor: MOVO-B; motif: GNGGGGG 0.0314684622652062 10261 74 53 0.716216216216216 0.0051651885781113
TF TF:M01104_1 Factor: MOVO-B; motif: GNGGGGG; match class: 1 0.0314684622652062 5626 74 35 0.472972972972973 0.00622111624600071
TF TF:M01721_1 Factor: PUR1; motif: GGGNCAGNN; match class: 1 0.0314684622652062 3414 74 25 0.337837837837838 0.0073227885178676
TF TF:M12354_1 Factor: ZNF37A; motif: CCYYGGCTCCNTSCCMN; match class: 1 0.0314684622652062 5624 74 35 0.472972972972973 0.00622332859174964
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.0320532502938273 6260 70 36 0.514285714285714 0.00575079872204473
TF TF:M01868_1 Factor: C/EBPepsilon; motif: HAANMTTKCNWMAC; match class: 1 0.0326635440142389 367 9 3 0.333333333333333 0.00817438692098093
TF TF:M12149_1 Factor: SP9; motif: RCCACGCCCMCY; match class: 1 0.0326635440142389 300 66 6 0.0909090909090909 0.02
TF TF:M07040_1 Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1 0.0327966287686657 8156 64 40 0.625 0.00490436488474743
TF TF:M00261 Factor: Olf-1; motif: NNCDABTCCCYAGRGARBNKGN 0.0327966287686657 3554 49 19 0.387755102040816 0.00534608891389983
TF TF:M11728_1 Factor: NF-1C; motif: NTTGGCNNNNTGCCARN; match class: 1 0.0342779641363923 1129 51 10 0.196078431372549 0.00885739592559787
TF TF:M12181 Factor: BTEB3; motif: NRCCACGCCCMCN 0.0343568032471859 1597 72 15 0.208333333333333 0.00939261114589856
TF TF:M10107_1 Factor: DB1; motif: GGRRRRGRRGGAGGGGGNGRRR; match class: 1 0.0343568032471859 2657 64 19 0.296875 0.00715092209258562
TF TF:M12183_1 Factor: KLF14; motif: NRCCACRCCCMCN; match class: 1 0.0346385587414529 2487 63 18 0.285714285714286 0.00723763570566948
TF TF:M03914_1 Factor: KLF16; motif: GMCACGCCCCC; match class: 1 0.0346385587414529 710 66 9 0.136363636363636 0.0126760563380282
TF TF:M10139 Factor: ZNF320; motif: GKGGGNCCMGGGGGCCWRTG 0.0348736952401125 688 12 4 0.333333333333333 0.00581395348837209
TF TF:M01656 Factor: p63; motif: RRACATGTCNRGACATGTYY 0.0372949868931655 3754 10 7 0.7 0.00186467767714438
TF TF:M01175 Factor: CKROX; motif: SCCCTCCCC 0.0378756368743293 7292 73 41 0.561643835616438 0.00562260010970927
TF TF:M09658 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS 0.0384135820500873 5262 74 33 0.445945945945946 0.00627137970353478
TF TF:M01100 Factor: LRF; motif: GGGGKYNNB 0.0384135820500873 7557 73 42 0.575342465753425 0.0055577610162763
TF TF:M05544 Factor: BCL-11A; motif: CSTAMGGA 0.0386770596005792 409 20 4 0.2 0.0097799511002445
TF TF:M03807_1 Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 0.0408030796375787 4199 70 27 0.385714285714286 0.0064301024053346
TF TF:M08330 Factor: GCMb:FIGLA; motif: ATGCGGGTNCASSTG 0.0408030796375787 376 57 6 0.105263157894737 0.0159574468085106
TF TF:M01219 Factor: SP1:SP3; motif: CCSCCCCCYCC 0.0408030796375787 6812 64 35 0.546875 0.00513799177921315
TF TF:M01837_1 Factor: FKLF; motif: BGGGNGGVMD; match class: 1 0.040845043364091 1413 43 10 0.232558139534884 0.00707714083510262
TF TF:M08878 Factor: EGR; motif: CGCCCCCGCNN 0.0416648765535589 7483 74 42 0.567567567567568 0.00561272217025257
TF TF:M09984_1 Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1 0.0420817753515869 5555 74 34 0.459459459459459 0.00612061206120612
TF TF:M04953_1 Factor: Sp1; motif: GGNDGGRGGCGGGG; match class: 1 0.0420817753515869 4065 69 26 0.376811594202899 0.00639606396063961
TF TF:M12174_1 Factor: GKLF; motif: NNCCACRCCCN; match class: 1 0.0420817753515869 324 45 5 0.111111111111111 0.0154320987654321
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.0420817753515869 7728 70 41 0.585714285714286 0.00530538302277433
TF TF:M12092 Factor: ZNF787; motif: TGCCTCAGTTTMCCN 0.0420817753515869 634 14 4 0.285714285714286 0.00630914826498423
TF TF:M00915 Factor: AP-2; motif: SNNNCCNCAGGCN 0.0420817753515869 9612 74 50 0.675675675675676 0.00520183104452767
TF TF:M12181_1 Factor: BTEB3; motif: NRCCACGCCCMCN; match class: 1 0.0420817753515869 183 45 4 0.0888888888888889 0.0218579234972678
TF TF:M09837 Factor: ZNF449; motif: NNNAGCCCARCC 0.0443686277502533 4264 63 25 0.396825396825397 0.00586303939962477
TF TF:M12227 Factor: ZIC4; motif: NNCCNCCCRYNGYGN 0.0448333345402804 11063 74 55 0.743243243243243 0.00497152671065715
TF TF:M08458_1 Factor: Erm:C/EBPdelta; motif: RSCGGAWRTTGCGYAAY; match class: 1 0.0457275158972545 3168 9 6 0.666666666666667 0.00189393939393939
TF TF:M10026 Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN 0.0465933999726148 8389 64 40 0.625 0.00476814876624151
TF TF:M01652 Factor: p53; motif: RGRCWWGYCYNGRCWWGYYY 0.0465933999726148 8083 74 44 0.594594594594595 0.00544352344426574
TF TF:M12057 Factor: ZBP99; motif: GCCCMTCCCCCR 0.0465933999726148 5225 73 32 0.438356164383562 0.0061244019138756
TF TF:M00245 Factor: Egr-3; motif: NTGCGTGGGCGK 0.0465933999726148 7313 74 41 0.554054054054054 0.00560645425953781
TF TF:M08315 Factor: GCMa:FIGLA; motif: CASSTGNACCCGCAY 0.0465933999726148 977 63 10 0.158730158730159 0.0102354145342886
TF TF:M07277 Factor: BTEB2; motif: RGGGNGKGGN 0.0465933999726148 8492 71 44 0.619718309859155 0.00518134715025907
TF TF:M08233_1 Factor: ERF:C/EBPdelta; motif: NNCGGAWRTTGCGCAAY; match class: 1 0.0465933999726148 1101 38 8 0.210526315789474 0.0072661217075386
TF TF:M12351 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC 0.0468507988122036 12302 74 59 0.797297297297297 0.00479596813526256
TF TF:M12147 Factor: SP8; motif: RNCACGCCCMCN 0.0475499988023312 2465 72 19 0.263888888888889 0.0077079107505071
TF TF:M09739 Factor: ZGPAT; motif: GRGGCWGNGGNG 0.0475499988023312 8226 75 45 0.6 0.00547045951859956
TF TF:M03567_1 Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 0.0475499988023312 3614 70 24 0.342857142857143 0.00664084117321527
TF TF:M00649 Factor: MAZ; motif: GGGGAGGG 0.0489052701988392 9327 73 48 0.657534246575342 0.00514634930845931
TF TF:M08571_1 Factor: Erm:E2A; motif: CASGTGNNNCGGAAGNN; match class: 1 0.0489052701988392 4425 75 29 0.386666666666667 0.00655367231638418
TF TF:M03923 Factor: SP8; motif: RCCACGCCCMCY 0.0495440522013565 2843 73 21 0.287671232876712 0.0073865634892719
TF TF:M03913 Factor: KLF14; motif: NRCCACGCCCMCYN 0.0495440522013565 628 66 8 0.121212121212121 0.0127388535031847
WP WP:WP477 Cytoplasmic Ribosomal Proteins 0.000203189752919343 90 10 4 0.4 0.0444444444444444

pP01 transcription factor target enrichment of top program genes

TF enrichment of pP01
TFs corrosponding to activation of pP01. (Left) pearson correlation of TF expression and gene expression program activatity in Plasma cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.