pEpi16 program activity among Epithelial cells

Activation of pEpi16
pEpi16 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi16 by different cell subtypes
pEpi16 gene program activation among cells of different subtypes (Epithelial cells).

pEpi16 top program genes

Top genes of pEpi16 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi16 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi16
pEpi16 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0044281 small molecule metabolic process 1.57234696940933e-08 1921 88 34 0.386363636363636 0.0176991150442478
GO:BP GO:0043436 oxoacid metabolic process 9.49525083026421e-07 1057 87 23 0.264367816091954 0.021759697256386
GO:BP GO:0006082 organic acid metabolic process 1.14965187656649e-06 1090 87 23 0.264367816091954 0.0211009174311927
GO:BP GO:0006629 lipid metabolic process 1.90849190370906e-06 1457 87 26 0.298850574712644 0.0178448867536033
GO:BP GO:0006065 UDP-glucuronate biosynthetic process 9.3539035435248e-06 3 45 3 0.0666666666666667 1
GO:BP GO:0006790 sulfur compound metabolic process 9.57131706000232e-06 386 43 10 0.232558139534884 0.0259067357512953
GO:BP GO:0033875 ribonucleoside bisphosphate metabolic process 9.97437496084289e-06 141 88 9 0.102272727272727 0.0638297872340425
GO:BP GO:0034032 purine nucleoside bisphosphate metabolic process 9.97437496084289e-06 141 88 9 0.102272727272727 0.0638297872340425
GO:BP GO:0033865 nucleoside bisphosphate metabolic process 9.97437496084289e-06 141 88 9 0.102272727272727 0.0638297872340425
GO:BP GO:0019752 carboxylic acid metabolic process 1.59177981465482e-05 1024 111 23 0.207207207207207 0.0224609375
GO:BP GO:0046398 UDP-glucuronate metabolic process 1.6977522240536e-05 4 45 3 0.0666666666666667 0.75
GO:BP GO:1901135 carbohydrate derivative metabolic process 4.07421780074072e-05 1145 106 23 0.216981132075472 0.0200873362445415
GO:BP GO:1901615 organic hydroxy compound metabolic process 5.08675711462446e-05 571 69 13 0.188405797101449 0.0227670753064799
GO:BP GO:0044255 cellular lipid metabolic process 0.000145340127752974 1075 87 19 0.218390804597701 0.0176744186046512
GO:BP GO:0014070 response to organic cyclic compound 0.00026196168460186 967 130 22 0.169230769230769 0.0227507755946225
GO:BP GO:0044282 small molecule catabolic process 0.00026196168460186 439 139 15 0.107913669064748 0.0341685649202733
GO:BP GO:0015711 organic anion transport 0.000280337131637998 386 120 13 0.108333333333333 0.0336787564766839
GO:BP GO:0032528 microvillus organization 0.000280337131637998 24 67 4 0.0597014925373134 0.166666666666667
GO:BP GO:0055086 nucleobase-containing small molecule metabolic process 0.000391863183204219 629 45 10 0.222222222222222 0.0158982511923688
GO:BP GO:0048878 chemical homeostasis 0.000516766470577432 1229 143 26 0.181818181818182 0.0211554109031733
GO:BP GO:0019395 fatty acid oxidation 0.000539618728998856 108 110 7 0.0636363636363636 0.0648148148148148
GO:BP GO:0071407 cellular response to organic cyclic compound 0.000539618728998856 587 130 16 0.123076923076923 0.0272572402044293
GO:BP GO:0009268 response to pH 0.000539618728998856 44 14 3 0.214285714285714 0.0681818181818182
GO:BP GO:0008202 steroid metabolic process 0.000539618728998856 342 67 9 0.134328358208955 0.0263157894736842
GO:BP GO:0034440 lipid oxidation 0.000621585187967185 113 110 7 0.0636363636363636 0.0619469026548673
GO:BP GO:0006635 fatty acid beta-oxidation 0.00069664961021186 76 110 6 0.0545454545454545 0.0789473684210526
GO:BP GO:0034310 primary alcohol catabolic process 0.00069664961021186 16 43 3 0.0697674418604651 0.1875
GO:BP GO:0032787 monocarboxylic acid metabolic process 0.000701624544904579 658 120 16 0.133333333333333 0.0243161094224924
GO:BP GO:0065008 regulation of biological quality 0.00111187989665126 4131 138 54 0.391304347826087 0.0130718954248366
GO:BP GO:0006810 transport 0.00113021271010369 5224 131 61 0.465648854961832 0.011676875957121
GO:BP GO:0006066 alcohol metabolic process 0.00122217363209798 382 69 9 0.130434782608696 0.0235602094240838
GO:BP GO:0006820 anion transport 0.00122217363209798 2889 125 39 0.312 0.0134994807892004
GO:BP GO:0071702 organic substance transport 0.00122217363209798 2766 125 38 0.304 0.0137382501807664
GO:BP GO:0034030 ribonucleoside bisphosphate biosynthetic process 0.001401659998815 68 88 5 0.0568181818181818 0.0735294117647059
GO:BP GO:0034033 purine nucleoside bisphosphate biosynthetic process 0.001401659998815 68 88 5 0.0568181818181818 0.0735294117647059
GO:BP GO:0009150 purine ribonucleotide metabolic process 0.001401659998815 414 120 12 0.1 0.0289855072463768
GO:BP GO:0033866 nucleoside bisphosphate biosynthetic process 0.001401659998815 68 88 5 0.0568181818181818 0.0735294117647059
GO:BP GO:0050801 ion homeostasis 0.001401659998815 808 143 19 0.132867132867133 0.0235148514851485
GO:BP GO:0016042 lipid catabolic process 0.00145878166943978 349 143 12 0.0839160839160839 0.0343839541547278
GO:BP GO:0019637 organophosphate metabolic process 0.001496159017792 1041 43 11 0.255813953488372 0.010566762728146
GO:BP GO:0006631 fatty acid metabolic process 0.00154061113218803 404 87 10 0.114942528735632 0.0247524752475248
GO:BP GO:0009226 nucleotide-sugar biosynthetic process 0.00156856994690703 23 45 3 0.0666666666666667 0.130434782608696
GO:BP GO:0030033 microvillus assembly 0.00164277238153324 16 67 3 0.0447761194029851 0.1875
GO:BP GO:0034035 purine ribonucleoside bisphosphate metabolic process 0.00171144869345136 26 43 3 0.0697674418604651 0.115384615384615
GO:BP GO:0051234 establishment of localization 0.00171144869345136 5372 131 61 0.465648854961832 0.011355174981385
GO:BP GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process 0.00171144869345136 26 43 3 0.0697674418604651 0.115384615384615
GO:BP GO:0034308 primary alcohol metabolic process 0.00171144869345136 95 69 5 0.072463768115942 0.0526315789473684
GO:BP GO:0098656 anion transmembrane transport 0.00171144869345136 550 3 3 1 0.00545454545454545
GO:BP GO:0098771 inorganic ion homeostasis 0.00171144869345136 761 143 18 0.125874125874126 0.0236530880420499
GO:BP GO:0009259 ribonucleotide metabolic process 0.00171144869345136 431 120 12 0.1 0.0278422273781903
GO:BP GO:0042572 retinol metabolic process 0.00176893135832046 48 69 4 0.0579710144927536 0.0833333333333333
GO:BP GO:0015849 organic acid transport 0.00189694035792401 331 111 10 0.0900900900900901 0.0302114803625378
GO:BP GO:0019693 ribose phosphate metabolic process 0.00189694035792401 441 120 12 0.1 0.0272108843537415
GO:BP GO:0030641 regulation of cellular pH 0.00204283790130944 95 120 6 0.05 0.0631578947368421
GO:BP GO:0006163 purine nucleotide metabolic process 0.00220176639460891 450 120 12 0.1 0.0266666666666667
GO:BP GO:0006811 ion transport 0.00220176639460891 3661 138 48 0.347826086956522 0.0131111718109806
GO:BP GO:0009062 fatty acid catabolic process 0.00233952480158718 107 110 6 0.0545454545454545 0.0560747663551402
GO:BP GO:0030050 vesicle transport along actin filament 0.00276317483656837 18 77 3 0.038961038961039 0.166666666666667
GO:BP GO:0030029 actin filament-based process 0.00284212074471674 808 60 11 0.183333333333333 0.0136138613861386
GO:BP GO:0006885 regulation of pH 0.00290200243230872 103 120 6 0.05 0.058252427184466
GO:BP GO:0072329 monocarboxylic acid catabolic process 0.00295437646120185 132 137 7 0.0510948905109489 0.053030303030303
GO:BP GO:0072521 purine-containing compound metabolic process 0.00320993306559426 473 120 12 0.1 0.025369978858351
GO:BP GO:0030036 actin cytoskeleton organization 0.00332289024305985 709 58 10 0.172413793103448 0.0141043723554302
GO:BP GO:0099515 actin filament-based transport 0.00347866040375983 20 77 3 0.038961038961039 0.15
GO:BP GO:0044242 cellular lipid catabolic process 0.00367515052219828 232 110 8 0.0727272727272727 0.0344827586206897
GO:BP GO:0035383 thioester metabolic process 0.0039892357181815 105 79 5 0.0632911392405063 0.0476190476190476
GO:BP GO:0006637 acyl-CoA metabolic process 0.0039892357181815 105 79 5 0.0632911392405063 0.0476190476190476
GO:BP GO:0006839 mitochondrial transport 0.00409321251992237 284 118 9 0.076271186440678 0.0316901408450704
GO:BP GO:0045600 positive regulation of fat cell differentiation 0.00409321251992237 67 126 5 0.0396825396825397 0.0746268656716418
GO:BP GO:0006721 terpenoid metabolic process 0.00410448053088621 123 69 5 0.072463768115942 0.040650406504065
GO:BP GO:0003013 circulatory system process 0.00410448053088621 637 138 15 0.108695652173913 0.0235478806907378
GO:BP GO:1901616 organic hydroxy compound catabolic process 0.00417793511966908 80 56 4 0.0714285714285714 0.05
GO:BP GO:0060088 auditory receptor cell stereocilium organization 0.00417829308148661 15 116 3 0.0258620689655172 0.2
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 0.00419137518268928 686 101 13 0.128712871287129 0.0189504373177843
GO:BP GO:0009225 nucleotide-sugar metabolic process 0.00421884326048877 38 45 3 0.0666666666666667 0.0789473684210526
GO:BP GO:0061024 membrane organization 0.00449732240147391 973 125 18 0.144 0.0184994861253854
GO:BP GO:0030004 cellular monovalent inorganic cation homeostasis 0.0048142037590699 118 120 6 0.05 0.0508474576271186
GO:BP GO:0000038 very long-chain fatty acid metabolic process 0.00484896647555776 35 137 4 0.0291970802919708 0.114285714285714
GO:BP GO:0008610 lipid biosynthetic process 0.00526224321036767 740 84 12 0.142857142857143 0.0162162162162162
GO:BP GO:0048732 gland development 0.00558993527413576 436 142 12 0.0845070422535211 0.0275229357798165
GO:BP GO:0002093 auditory receptor cell morphogenesis 0.00558993527413576 17 116 3 0.0258620689655172 0.176470588235294
GO:BP GO:0016054 organic acid catabolic process 0.00564010257362053 262 137 9 0.0656934306569343 0.0343511450381679
GO:BP GO:0034754 cellular hormone metabolic process 0.00620556678560399 140 69 5 0.072463768115942 0.0357142857142857
GO:BP GO:0042445 hormone metabolic process 0.00624517993113266 228 43 5 0.116279069767442 0.0219298245614035
GO:BP GO:0006720 isoprenoid metabolic process 0.00680823745644317 144 69 5 0.072463768115942 0.0347222222222222
GO:BP GO:0033559 unsaturated fatty acid metabolic process 0.00695910878591513 116 47 4 0.0851063829787234 0.0344827586206897
GO:BP GO:0060119 inner ear receptor cell development 0.00695910878591513 47 116 4 0.0344827586206897 0.0851063829787234
GO:BP GO:0050892 intestinal absorption 0.00706842412419796 40 138 4 0.0289855072463768 0.1
GO:BP GO:0055085 transmembrane transport 0.00706842412419796 1635 138 26 0.188405797101449 0.0159021406727829
GO:BP GO:0009117 nucleotide metabolic process 0.00761485110011661 544 120 12 0.1 0.0220588235294118
GO:BP GO:0055067 monovalent inorganic cation homeostasis 0.00761485110011661 165 137 7 0.0510948905109489 0.0424242424242424
GO:BP GO:0055080 cation homeostasis 0.00812797088507312 750 143 16 0.111888111888112 0.0213333333333333
GO:BP GO:0044283 small molecule biosynthetic process 0.00812797088507312 704 81 11 0.135802469135802 0.015625
GO:BP GO:0006693 prostaglandin metabolic process 0.00814927116501029 50 47 3 0.0638297872340425 0.06
GO:BP GO:0006692 prostanoid metabolic process 0.00814927116501029 50 47 3 0.0638297872340425 0.06
GO:BP GO:0006690 icosanoid metabolic process 0.00815053413843249 124 47 4 0.0851063829787234 0.032258064516129
GO:BP GO:0006753 nucleoside phosphate metabolic process 0.00820286465008993 555 43 7 0.162790697674419 0.0126126126126126
GO:BP GO:0060117 auditory receptor cell development 0.00825630783464205 21 116 3 0.0258620689655172 0.142857142857143
GO:BP GO:0042592 homeostatic process 0.00825630783464205 1981 143 30 0.20979020979021 0.0151438667339727
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.00825630783464205 1227 99 17 0.171717171717172 0.0138549307253464
GO:BP GO:0051453 regulation of intracellular pH 0.00825630783464205 89 120 5 0.0416666666666667 0.0561797752808989
GO:BP GO:0070887 cellular response to chemical stimulus 0.00825630783464205 3393 114 37 0.324561403508772 0.0109048040082523
GO:BP GO:0150104 transport across blood-brain barrier 0.00839491646029732 87 125 5 0.04 0.0574712643678161
GO:BP GO:0098927 vesicle-mediated transport between endosomal compartments 0.0084496859500395 42 59 3 0.0508474576271186 0.0714285714285714
GO:BP GO:0046164 alcohol catabolic process 0.00850235897676082 58 43 3 0.0697674418604651 0.0517241379310345
GO:BP GO:0034220 ion transmembrane transport 0.00850235897676082 1397 138 23 0.166666666666667 0.0164638511095204
GO:BP GO:0010232 vascular transport 0.00859162408141045 88 125 5 0.04 0.0568181818181818
GO:BP GO:1901568 fatty acid derivative metabolic process 0.00885525769752656 81 137 5 0.0364963503649635 0.0617283950617284
GO:BP GO:0032870 cellular response to hormone stimulus 0.00977107472801641 645 138 14 0.101449275362319 0.0217054263565891
GO:BP GO:0046942 carboxylic acid transport 0.0106208198783918 294 111 8 0.0720720720720721 0.0272108843537415
GO:BP GO:0001890 placenta development 0.0106630023941548 147 121 6 0.0495867768595041 0.0408163265306122
GO:BP GO:0030048 actin filament-based movement 0.0108792038257053 152 77 5 0.0649350649350649 0.0328947368421053
GO:BP GO:0006730 one-carbon metabolic process 0.010879995579548 39 71 3 0.0422535211267606 0.0769230769230769
GO:BP GO:0007015 actin filament organization 0.011819871787739 445 58 7 0.120689655172414 0.0157303370786517
GO:BP GO:0016482 cytosolic transport 0.0119798520188887 168 109 6 0.055045871559633 0.0357142857142857
GO:BP GO:0060561 apoptotic process involved in morphogenesis 0.0122300289822677 25 118 3 0.0254237288135593 0.12
GO:BP GO:0046395 carboxylic acid catabolic process 0.0122300289822677 245 137 8 0.0583941605839416 0.0326530612244898
GO:BP GO:1990542 mitochondrial transmembrane transport 0.013094420065192 114 108 5 0.0462962962962963 0.043859649122807
GO:BP GO:0048608 reproductive structure development 0.0131776057382668 429 121 10 0.0826446280991736 0.0233100233100233
GO:BP GO:0090407 organophosphate biosynthetic process 0.0136548407011911 598 88 10 0.113636363636364 0.0167224080267559
GO:BP GO:0061458 reproductive system development 0.0137229835413916 432 121 10 0.0826446280991736 0.0231481481481481
GO:BP GO:0032880 regulation of protein localization 0.0137570933520052 922 138 17 0.123188405797101 0.0184381778741865
GO:BP GO:0006576 cellular biogenic amine metabolic process 0.014156932206124 106 68 4 0.0588235294117647 0.0377358490566038
GO:BP GO:0046394 carboxylic acid biosynthetic process 0.014244491718805 330 81 7 0.0864197530864197 0.0212121212121212
GO:BP GO:0034314 Arp2/3 complex-mediated actin nucleation 0.0144812357142176 41 77 3 0.038961038961039 0.0731707317073171
GO:BP GO:0060113 inner ear receptor cell differentiation 0.0145917351762006 63 116 4 0.0344827586206897 0.0634920634920635
GO:BP GO:0001523 retinoid metabolic process 0.0150165284831198 107 69 4 0.0579710144927536 0.0373831775700935
GO:BP GO:0006694 steroid biosynthetic process 0.0150165284831198 196 66 5 0.0757575757575758 0.0255102040816327
GO:BP GO:0019915 lipid storage 0.0150661191321535 86 86 4 0.0465116279069767 0.0465116279069767
GO:BP GO:0016053 organic acid biosynthetic process 0.0157929070242376 338 81 7 0.0864197530864197 0.0207100591715976
GO:BP GO:0035337 fatty-acyl-CoA metabolic process 0.0160431301185089 42 79 3 0.0379746835443038 0.0714285714285714
GO:BP GO:0010817 regulation of hormone levels 0.0161885811552034 536 138 12 0.0869565217391304 0.0223880597014925
GO:BP GO:0043270 positive regulation of ion transport 0.0164616538219269 694 138 14 0.101449275362319 0.0201729106628242
GO:BP GO:0016101 diterpenoid metabolic process 0.017140374377532 113 69 4 0.0579710144927536 0.0353982300884956
GO:BP GO:0051649 establishment of localization in cell 0.0172808407038458 2813 109 30 0.275229357798165 0.0106647707074298
GO:BP GO:0031667 response to nutrient levels 0.0172808407038458 482 114 10 0.087719298245614 0.020746887966805
GO:BP GO:0006873 cellular ion homeostasis 0.0172808407038458 687 125 13 0.104 0.0189228529839884
GO:BP GO:0042490 mechanoreceptor differentiation 0.0172910694787426 68 116 4 0.0344827586206897 0.0588235294117647
GO:BP GO:0071496 cellular response to external stimulus 0.0173826910884784 322 114 8 0.0701754385964912 0.0248447204968944
GO:BP GO:0055082 cellular chemical homeostasis 0.0173826910884784 841 143 16 0.111888111888112 0.0190249702734839
GO:BP GO:0071417 cellular response to organonitrogen compound 0.0173826910884784 666 114 12 0.105263157894737 0.018018018018018
GO:BP GO:0010876 lipid localization 0.0173826910884784 530 123 11 0.0894308943089431 0.0207547169811321
GO:BP GO:0071705 nitrogen compound transport 0.0173826910884784 2322 125 29 0.232 0.012489233419466
GO:BP GO:0001676 long-chain fatty acid metabolic process 0.0177131999600383 112 72 4 0.0555555555555556 0.0357142857142857
GO:BP GO:0001889 liver development 0.0185976574881243 148 142 6 0.0422535211267606 0.0405405405405405
GO:BP GO:0051049 regulation of transport 0.0185976574881243 1809 138 26 0.188405797101449 0.0143725815367606
GO:BP GO:0071295 cellular response to vitamin 0.0190174492486261 33 114 3 0.0263157894736842 0.0909090909090909
GO:BP GO:0097305 response to alcohol 0.0190174492486261 255 114 7 0.0614035087719298 0.0274509803921569
GO:BP GO:0009056 catabolic process 0.019042256311389 2744 143 36 0.251748251748252 0.0131195335276968
GO:BP GO:0005975 carbohydrate metabolic process 0.0194910031611065 635 139 13 0.0935251798561151 0.0204724409448819
GO:BP GO:0061008 hepaticobiliary system development 0.0195165542787579 151 142 6 0.0422535211267606 0.0397350993377483
GO:BP GO:0030258 lipid modification 0.0208083384167132 271 110 7 0.0636363636363636 0.025830258302583
GO:BP GO:0032879 regulation of localization 0.0209393785261923 2872 138 36 0.260869565217391 0.0125348189415042
GO:BP GO:0071495 cellular response to endogenous stimulus 0.0210894275582477 1422 114 19 0.166666666666667 0.0133614627285513
GO:BP GO:0051650 establishment of vesicle localization 0.0214423775576782 214 103 6 0.058252427184466 0.0280373831775701
GO:BP GO:0060122 inner ear receptor cell stereocilium organization 0.022003307361193 35 116 3 0.0258620689655172 0.0857142857142857
GO:BP GO:0009991 response to extracellular stimulus 0.0222753783403102 512 114 10 0.087719298245614 0.01953125
GO:BP GO:1901700 response to oxygen-containing compound 0.0228004678513175 1739 102 20 0.196078431372549 0.0115008625646924
GO:BP GO:0055114 obsolete oxidation-reduction process 0.0230361619001711 745 137 14 0.102189781021898 0.0187919463087248
GO:BP GO:1903351 cellular response to dopamine 0.0230361619001711 86 48 3 0.0625 0.0348837209302326
GO:BP GO:0044272 sulfur compound biosynthetic process 0.0230361619001711 193 79 5 0.0632911392405063 0.0259067357512953
GO:BP GO:0007010 cytoskeleton organization 0.0230760789358035 1423 58 12 0.206896551724138 0.0084328882642305
GO:BP GO:1903350 response to dopamine 0.0230760789358035 87 48 3 0.0625 0.0344827586206897
GO:BP GO:0042491 inner ear auditory receptor cell differentiation 0.0230760789358035 36 116 3 0.0258620689655172 0.0833333333333333
GO:BP GO:0051179 localization 0.0236639128231701 6901 111 58 0.522522522522523 0.008404579046515
GO:BP GO:0002446 neutrophil mediated immunity 0.0239367771506474 497 140 11 0.0785714285714286 0.0221327967806841
GO:BP GO:0006793 phosphorus metabolic process 0.0239367771506474 3114 143 39 0.272727272727273 0.01252408477842
GO:BP GO:0046907 intracellular transport 0.0239532922215787 1767 123 23 0.186991869918699 0.0130164119977363
GO:BP GO:0090316 positive regulation of intracellular protein transport 0.0240547548348343 186 123 6 0.0487804878048781 0.032258064516129
GO:BP GO:0042493 response to drug 0.0240977988966664 396 125 9 0.072 0.0227272727272727
GO:BP GO:0051050 positive regulation of transport 0.0248836506972703 923 138 16 0.115942028985507 0.0173347778981582
GO:BP GO:0009152 purine ribonucleotide biosynthetic process 0.0250125900608686 179 88 5 0.0568181818181818 0.0279329608938547
GO:BP GO:0071248 cellular response to metal ion 0.0252201552197865 192 121 6 0.0495867768595041 0.03125
GO:BP GO:0045010 actin nucleation 0.0252201552197865 57 77 3 0.038961038961039 0.0526315789473684
GO:BP GO:0048771 tissue remodeling 0.0252359172040466 186 125 6 0.048 0.032258064516129
GO:BP GO:0009913 epidermal cell differentiation 0.0262491513050279 365 65 6 0.0923076923076923 0.0164383561643836
GO:BP GO:0033572 transferrin transport 0.0262491513050279 36 125 3 0.024 0.0833333333333333
GO:BP GO:1901699 cellular response to nitrogen compound 0.0265640709905902 724 99 11 0.111111111111111 0.0151933701657459
GO:BP GO:0051648 vesicle localization 0.0268511466469421 230 103 6 0.058252427184466 0.0260869565217391
GO:BP GO:0060341 regulation of cellular localization 0.0275539813871987 851 138 15 0.108695652173913 0.0176263219741481
GO:BP GO:0072583 clathrin-dependent endocytosis 0.0276796622478821 46 101 3 0.0297029702970297 0.0652173913043478
GO:BP GO:1902742 apoptotic process involved in development 0.02848157674972 40 118 3 0.0254237288135593 0.075
GO:BP GO:0097435 supramolecular fiber organization 0.02848157674972 734 58 8 0.137931034482759 0.0108991825613079
GO:BP GO:0015748 organophosphate ester transport 0.0293886713902158 136 123 5 0.040650406504065 0.0367647058823529
GO:BP GO:1901570 fatty acid derivative biosynthetic process 0.0296965806592976 61 79 3 0.0379746835443038 0.0491803278688525
GO:BP GO:0030003 cellular cation homeostasis 0.0296965806592976 673 125 12 0.096 0.0178306092124814
GO:BP GO:0009260 ribonucleotide biosynthetic process 0.0301003405142976 192 88 5 0.0568181818181818 0.0260416666666667
GO:BP GO:0071870 cellular response to catecholamine stimulus 0.0303881191242609 102 48 3 0.0625 0.0294117647058824
GO:BP GO:0071868 cellular response to monoamine stimulus 0.0303881191242609 102 48 3 0.0625 0.0294117647058824
GO:BP GO:1905039 carboxylic acid transmembrane transport 0.0311715312924493 154 111 5 0.045045045045045 0.0324675324675325
GO:BP GO:0032868 response to insulin 0.0314657754896151 295 114 7 0.0614035087719298 0.023728813559322
GO:BP GO:0031669 cellular response to nutrient levels 0.0314657754896151 219 114 6 0.0526315789473684 0.0273972602739726
GO:BP GO:1903825 organic acid transmembrane transport 0.0314752415939015 155 111 5 0.045045045045045 0.032258064516129
GO:BP GO:0032535 regulation of cellular component size 0.0317987326769032 388 28 4 0.142857142857143 0.0103092783505155
GO:BP GO:0071869 response to catecholamine 0.0317987326769032 106 48 3 0.0625 0.0283018867924528
GO:BP GO:0071867 response to monoamine 0.0317987326769032 106 48 3 0.0625 0.0283018867924528
GO:BP GO:0097306 cellular response to alcohol 0.0317987326769032 93 114 4 0.0350877192982456 0.043010752688172
GO:BP GO:0062013 positive regulation of small molecule metabolic process 0.0317987326769032 145 120 5 0.0416666666666667 0.0344827586206897
GO:BP GO:1901661 quinone metabolic process 0.0317987326769032 37 137 3 0.0218978102189781 0.0810810810810811
GO:BP GO:0090087 regulation of peptide transport 0.0317987326769032 618 138 12 0.0869565217391304 0.0194174757281553
GO:BP GO:0042594 response to starvation 0.0317987326769032 202 86 5 0.0581395348837209 0.0247524752475248
GO:BP GO:0031670 cellular response to nutrient 0.0318447045764755 45 114 3 0.0263157894736842 0.0666666666666667
GO:BP GO:0045598 regulation of fat cell differentiation 0.0318447045764755 139 126 5 0.0396825396825397 0.0359712230215827
GO:BP GO:0046390 ribose phosphate biosynthetic process 0.0318447045764755 199 88 5 0.0568181818181818 0.0251256281407035
GO:BP GO:1901575 organic substance catabolic process 0.0319234866097261 2267 143 30 0.20979020979021 0.0132333480370534
GO:BP GO:0055072 iron ion homeostasis 0.0324991607352836 86 125 4 0.032 0.0465116279069767
GO:BP GO:1902652 secondary alcohol metabolic process 0.0328710916055533 164 66 4 0.0606060606060606 0.024390243902439
GO:BP GO:0006164 purine nucleotide biosynthetic process 0.0328710916055533 202 88 5 0.0568181818181818 0.0247524752475248
GO:BP GO:0009101 glycoprotein biosynthetic process 0.0333457880045128 347 32 4 0.125 0.0115273775216138
GO:BP GO:0090596 sensory organ morphogenesis 0.0333457880045128 262 132 7 0.053030303030303 0.0267175572519084
GO:BP GO:0035315 hair cell differentiation 0.0338027024539874 46 116 3 0.0258620689655172 0.0652173913043478
GO:BP GO:0008064 regulation of actin polymerization or depolymerization 0.0339838251964421 193 28 3 0.107142857142857 0.0155440414507772
GO:BP GO:1901655 cellular response to ketone 0.0340964499073204 97 114 4 0.0350877192982456 0.0412371134020619
GO:BP GO:0030832 regulation of actin filament length 0.0340964499073204 194 28 3 0.107142857142857 0.0154639175257732
GO:BP GO:0030522 intracellular receptor signaling pathway 0.0340964499073204 284 92 6 0.0652173913043478 0.0211267605633803
GO:BP GO:0042221 response to chemical 0.0340964499073204 4781 121 46 0.380165289256198 0.00962141811336541
GO:BP GO:0044106 cellular amine metabolic process 0.0340964499073204 163 68 4 0.0588235294117647 0.0245398773006135
GO:BP GO:0009755 hormone-mediated signaling pathway 0.0346987969123407 202 130 6 0.0461538461538462 0.0297029702970297
GO:BP GO:0034764 positive regulation of transmembrane transport 0.0350083109560088 217 52 4 0.0769230769230769 0.0184331797235023
GO:BP GO:0034767 positive regulation of ion transmembrane transport 0.0350083109560088 217 52 4 0.0769230769230769 0.0184331797235023
GO:BP GO:0043583 ear development 0.0350083109560088 218 121 6 0.0495867768595041 0.0275229357798165
GO:BP GO:0003018 vascular process in circulatory system 0.0351578598462586 256 138 7 0.0507246376811594 0.02734375
GO:BP GO:0008217 regulation of blood pressure 0.0351578598462586 193 137 6 0.0437956204379562 0.0310880829015544
GO:BP GO:0071241 cellular response to inorganic substance 0.0354515319641776 220 121 6 0.0495867768595041 0.0272727272727273
GO:BP GO:0008654 phospholipid biosynthetic process 0.0354515319641776 274 42 4 0.0952380952380952 0.0145985401459854
GO:BP GO:0032386 regulation of intracellular transport 0.0354515319641776 367 123 8 0.0650406504065041 0.0217983651226158
GO:BP GO:0042471 ear morphogenesis 0.0354515319641776 116 48 3 0.0625 0.0258620689655172
GO:BP GO:0009308 amine metabolic process 0.0355051729249332 168 68 4 0.0588235294117647 0.0238095238095238
GO:BP GO:0048545 response to steroid hormone 0.0357456835855696 349 130 8 0.0615384615384615 0.0229226361031519
GO:BP GO:0032869 cellular response to insulin stimulus 0.0357456835855696 235 114 6 0.0526315789473684 0.025531914893617
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0357456835855696 551 140 11 0.0785714285714286 0.0199637023593466
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0357873547383114 717 140 13 0.0928571428571429 0.0181311018131102
GO:BP GO:0019216 regulation of lipid metabolic process 0.0359929820676577 419 86 7 0.0813953488372093 0.0167064439140811
GO:BP GO:0120254 olefinic compound metabolic process 0.0360797633506134 121 47 3 0.0638297872340425 0.0247933884297521
GO:BP GO:0072522 purine-containing compound biosynthetic process 0.0360797633506134 213 88 5 0.0568181818181818 0.0234741784037559
GO:BP GO:0015914 phospholipid transport 0.0362331007437501 94 123 4 0.032520325203252 0.0425531914893617
GO:BP GO:0051656 establishment of organelle localization 0.0362331007437501 445 103 8 0.0776699029126214 0.0179775280898876
GO:BP GO:0002263 cell activation involved in immune response 0.0363113730305872 721 140 13 0.0928571428571429 0.0180305131761442
GO:BP GO:0043269 regulation of ion transport 0.0363113730305872 1379 138 20 0.144927536231884 0.0145032632342277
GO:BP GO:0009719 response to endogenous stimulus 0.0364278167806965 1683 114 20 0.175438596491228 0.011883541295306
GO:BP GO:0099518 vesicle cytoskeletal trafficking 0.0364278167806965 75 77 3 0.038961038961039 0.04
GO:BP GO:0051452 intracellular pH reduction 0.037062878233405 56 104 3 0.0288461538461538 0.0535714285714286
GO:BP GO:0071383 cellular response to steroid hormone stimulus 0.0370666919664148 210 130 6 0.0461538461538462 0.0285714285714286
GO:BP GO:0018958 phenol-containing compound metabolic process 0.0370865397153325 110 107 4 0.0373831775700935 0.0363636363636364
GO:BP GO:0030855 epithelial cell differentiation 0.0378617313172945 798 72 9 0.125 0.0112781954887218
GO:BP GO:0043312 neutrophil degranulation 0.0381598771125854 482 140 10 0.0714285714285714 0.020746887966805
GO:BP GO:0002283 neutrophil activation involved in immune response 0.0392125675685848 485 140 10 0.0714285714285714 0.0206185567010309
GO:BP GO:0009725 response to hormone 0.0392125675685848 921 138 15 0.108695652173913 0.0162866449511401
GO:BP GO:0106027 neuron projection organization 0.0392125675685848 92 131 4 0.0305343511450382 0.0434782608695652
GO:BP GO:0007605 sensory perception of sound 0.0392337919857569 153 127 5 0.0393700787401575 0.0326797385620915
GO:BP GO:0003014 renal system process 0.0393850405274712 126 48 3 0.0625 0.0238095238095238
GO:BP GO:0009409 response to cold 0.0393850405274712 48 126 3 0.0238095238095238 0.0625
GO:BP GO:0042886 amide transport 0.0398828926691019 2007 131 25 0.190839694656489 0.0124564025909317
GO:BP GO:0019748 secondary metabolic process 0.039882911583224 57 107 3 0.0280373831775701 0.0526315789473684
GO:BP GO:0019725 cellular homeostasis 0.039882911583224 981 143 16 0.111888111888112 0.0163098878695209
GO:BP GO:0070839 metal ion export 0.0399041071001466 51 120 3 0.025 0.0588235294117647
GO:BP GO:0007595 lactation 0.0399527060846064 47 131 3 0.0229007633587786 0.0638297872340425
GO:BP GO:0045851 pH reduction 0.0399527060846064 59 104 3 0.0288461538461538 0.0508474576271186
GO:BP GO:0042306 regulation of protein import into nucleus 0.0399527060846064 62 99 3 0.0303030303030303 0.0483870967741935
GO:BP GO:0032388 positive regulation of intracellular transport 0.0399527060846064 229 123 6 0.0487804878048781 0.0262008733624454
GO:BP GO:0050873 brown fat cell differentiation 0.0401224794909922 49 126 3 0.0238095238095238 0.0612244897959184
GO:BP GO:0008154 actin polymerization or depolymerization 0.0401224794909922 223 28 3 0.107142857142857 0.0134529147982063
GO:BP GO:0031668 cellular response to extracellular stimulus 0.040140602800644 248 114 6 0.0526315789473684 0.0241935483870968
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.040140602800644 3087 143 37 0.258741258741259 0.0119857466796242
GO:BP GO:0032501 multicellular organismal process 0.0402062386917494 7946 27 19 0.703703703703704 0.0023911401963252
GO:BP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 0.0402840660880102 133 93 4 0.043010752688172 0.0300751879699248
GO:BP GO:0006091 generation of precursor metabolites and energy 0.0419316468195998 538 54 6 0.111111111111111 0.0111524163568773
GO:BP GO:0071277 cellular response to calcium ion 0.0424133581295759 84 76 3 0.0394736842105263 0.0357142857142857
GO:BP GO:0055088 lipid homeostasis 0.0424133581295759 167 121 5 0.0413223140495868 0.029940119760479
GO:BP GO:0042119 neutrophil activation 0.042748211838506 498 140 10 0.0714285714285714 0.0200803212851406
GO:BP GO:1904589 regulation of protein import 0.04288976620325 65 99 3 0.0303030303030303 0.0461538461538462
GO:BP GO:0006869 lipid transport 0.0429886505392281 480 123 9 0.0731707317073171 0.01875
GO:BP GO:0045017 glycerolipid biosynthetic process 0.0429886505392281 268 143 7 0.048951048951049 0.0261194029850746
GO:BP GO:0015909 long-chain fatty acid transport 0.0429886505392281 75 86 3 0.0348837209302326 0.04
GO:BP GO:0009628 response to abiotic stimulus 0.0432631648715704 1261 114 16 0.140350877192982 0.0126883425852498
GO:BP GO:0071375 cellular response to peptide hormone stimulus 0.0447079755152893 340 114 7 0.0614035087719298 0.0205882352941176
GO:BP GO:0036230 granulocyte activation 0.044925082968929 504 140 10 0.0714285714285714 0.0198412698412698
GO:BP GO:0022600 digestive system process 0.0452534512793679 102 65 3 0.0461538461538462 0.0294117647058824
GO:BP GO:0007584 response to nutrient 0.0452534512793679 182 114 5 0.043859649122807 0.0274725274725275
GO:BP GO:0043627 response to estrogen 0.0461066050701167 78 86 3 0.0348837209302326 0.0384615384615385
GO:BP GO:0010243 response to organonitrogen compound 0.0461066050701167 1085 99 13 0.131313131313131 0.0119815668202765
GO:BP GO:0015718 monocarboxylic acid transport 0.0461936942378518 189 111 5 0.045045045045045 0.0264550264550265
GO:BP GO:0033993 response to lipid 0.0463418880912177 918 130 14 0.107692307692308 0.0152505446623094
GO:BP GO:0062197 cellular response to chemical stress 0.0465049351550366 365 108 7 0.0648148148148148 0.0191780821917808
GO:BP GO:0090066 regulation of anatomical structure size 0.0468529844911449 518 138 10 0.072463768115942 0.0193050193050193
GO:BP GO:0009100 glycoprotein metabolic process 0.0468529844911449 424 32 4 0.125 0.00943396226415094
GO:BP GO:1901264 carbohydrate derivative transport 0.0476647481329995 88 78 3 0.0384615384615385 0.0340909090909091
GO:BP GO:0003008 system process 0.0477582279815979 2293 143 29 0.202797202797203 0.012647187091147
GO:BP GO:0001503 ossification 0.0498793667835416 417 121 8 0.0661157024793388 0.0191846522781775
GO:BP GO:0048513 animal organ development 0.0498793667835416 3672 132 39 0.295454545454545 0.0106209150326797
GO:CC GO:0070062 extracellular exosome 2.51475158101136e-10 2176 139 48 0.345323741007194 0.0220588235294118
GO:CC GO:0043230 extracellular organelle 3.54465751738031e-10 2263 139 48 0.345323741007194 0.0212107821475917
GO:CC GO:1903561 extracellular vesicle 3.54465751738031e-10 2261 139 48 0.345323741007194 0.0212295444493587
GO:CC GO:0031982 vesicle 2.84824388135362e-07 4055 140 61 0.435714285714286 0.0150431565967941
GO:CC GO:0005902 microvillus 1.52529831030451e-05 91 53 6 0.113207547169811 0.0659340659340659
GO:CC GO:0005615 extracellular space 1.65135764762769e-05 3594 139 52 0.37410071942446 0.0144685587089594
GO:CC GO:0005737 cytoplasm 2.3497817644399e-05 11911 110 93 0.845454545454545 0.00780790865586433
GO:CC GO:0005576 extracellular region 3.57838275053754e-05 4567 140 60 0.428571428571429 0.013137727173199
GO:CC GO:0098858 actin-based cell projection 4.03487890736016e-05 220 67 8 0.119402985074627 0.0363636363636364
GO:CC GO:0030864 cortical actin cytoskeleton 4.03487890736016e-05 79 127 7 0.0551181102362205 0.0886075949367089
GO:CC GO:0005903 brush border 7.40888694056353e-05 107 67 6 0.0895522388059701 0.0560747663551402
GO:CC GO:0015629 actin cytoskeleton 8.37472212967005e-05 513 131 15 0.114503816793893 0.0292397660818713
GO:CC GO:0005764 lysosome 8.37472212967005e-05 712 109 16 0.146788990825688 0.0224719101123595
GO:CC GO:0000323 lytic vacuole 8.37472212967005e-05 712 109 16 0.146788990825688 0.0224719101123595
GO:CC GO:0043227 membrane-bounded organelle 9.95658525201235e-05 12858 112 97 0.866071428571429 0.00754394151501011
GO:CC GO:0098862 cluster of actin-based cell projections 0.000167105523197358 162 116 8 0.0689655172413793 0.0493827160493827
GO:CC GO:0030863 cortical cytoskeleton 0.00017365665994132 107 127 7 0.0551181102362205 0.0654205607476635
GO:CC GO:0098588 bounding membrane of organelle 0.000184961950628205 2158 109 29 0.26605504587156 0.0134383688600556
GO:CC GO:0031090 organelle membrane 0.000234241318199664 3612 109 40 0.36697247706422 0.0110741971207087
GO:CC GO:0005773 vacuole 0.000296204697012858 810 109 16 0.146788990825688 0.0197530864197531
GO:CC GO:0016323 basolateral plasma membrane 0.000669162844780173 222 138 9 0.0652173913043478 0.0405405405405405
GO:CC GO:0043226 organelle 0.000786140997103446 14008 112 100 0.892857142857143 0.00713877784123358
GO:CC GO:0005938 cell cortex 0.000786140997103446 311 127 10 0.078740157480315 0.0321543408360129
GO:CC GO:0005739 mitochondrion 0.00122179839019818 1673 110 23 0.209090909090909 0.013747758517633
GO:CC GO:0009925 basal plasma membrane 0.00127808146081939 247 138 9 0.0652173913043478 0.0364372469635627
GO:CC GO:0098590 plasma membrane region 0.00127808146081939 1240 5 4 0.8 0.0032258064516129
GO:CC GO:0005884 actin filament 0.00162944917637818 118 77 5 0.0649350649350649 0.0423728813559322
GO:CC GO:0045178 basal part of cell 0.00188347230036599 265 138 9 0.0652173913043478 0.0339622641509434
GO:CC GO:0098562 cytoplasmic side of membrane 0.00221095458656572 194 114 7 0.0614035087719298 0.0360824742268041
GO:CC GO:0005769 early endosome 0.00254014764310711 378 125 10 0.08 0.0264550264550265
GO:CC GO:0031903 microbody membrane 0.00283112494344971 64 90 4 0.0444444444444444 0.0625
GO:CC GO:0005778 peroxisomal membrane 0.00283112494344971 64 90 4 0.0444444444444444 0.0625
GO:CC GO:0005768 endosome 0.00296231068851094 987 125 17 0.136 0.0172239108409321
GO:CC GO:0005783 endoplasmic reticulum 0.0034457719612675 1982 109 24 0.220183486238532 0.012108980827447
GO:CC GO:0098852 lytic vacuole membrane 0.00372426595433869 383 109 9 0.0825688073394495 0.0234986945169713
GO:CC GO:0032420 stereocilium 0.00372426595433869 55 116 4 0.0344827586206897 0.0727272727272727
GO:CC GO:0005765 lysosomal membrane 0.00372426595433869 383 109 9 0.0825688073394495 0.0234986945169713
GO:CC GO:0009898 cytoplasmic side of plasma membrane 0.00529232892333886 168 114 6 0.0526315789473684 0.0357142857142857
GO:CC GO:0032421 stereocilium bundle 0.0054329241070612 62 116 4 0.0344827586206897 0.0645161290322581
GO:CC GO:0043229 intracellular organelle 0.00548768032156231 12491 104 84 0.807692307692308 0.00672484188615803
GO:CC GO:0005622 intracellular anatomical structure 0.00548768032156231 14790 112 101 0.901785714285714 0.0068289384719405
GO:CC GO:0030139 endocytic vesicle 0.00592734779689994 306 118 8 0.0677966101694915 0.0261437908496732
GO:CC GO:0045177 apical part of cell 0.00637873372005749 431 48 6 0.125 0.0139211136890951
GO:CC GO:0016328 lateral plasma membrane 0.00640538397257432 68 114 4 0.0350877192982456 0.0588235294117647
GO:CC GO:0012505 endomembrane system 0.00640538397257432 4640 109 42 0.385321100917431 0.00905172413793104
GO:CC GO:0030140 trans-Golgi network transport vesicle 0.00719167545710301 33 109 3 0.0275229357798165 0.0909090909090909
GO:CC GO:0005774 vacuolar membrane 0.00783712450877318 441 109 9 0.0825688073394495 0.0204081632653061
GO:CC GO:0031252 cell leading edge 0.00783712450877318 422 114 9 0.0789473684210526 0.0213270142180095
GO:CC GO:0031410 cytoplasmic vesicle 0.00801891105683399 2424 109 26 0.238532110091743 0.0107260726072607
GO:CC GO:0032432 actin filament bundle 0.00801891105683399 76 112 4 0.0357142857142857 0.0526315789473684
GO:CC GO:0097708 intracellular vesicle 0.00806152263008006 2428 109 26 0.238532110091743 0.0107084019769358
GO:CC GO:0031526 brush border membrane 0.00848627946101687 59 67 3 0.0447761194029851 0.0508474576271186
GO:CC GO:0005856 cytoskeleton 0.0109322032722018 2332 59 16 0.271186440677966 0.00686106346483705
GO:CC GO:0005925 focal adhesion 0.0120343568945938 420 59 6 0.101694915254237 0.0142857142857143
GO:CC GO:0010008 endosome membrane 0.0120343568945938 505 125 10 0.08 0.0198019801980198
GO:CC GO:0030055 cell-substrate junction 0.0128655101963531 427 59 6 0.101694915254237 0.0140515222482436
GO:CC GO:0005798 Golgi-associated vesicle 0.0129487815142105 94 109 4 0.036697247706422 0.0425531914893617
GO:CC GO:0120025 plasma membrane bounded cell projection 0.015673301847453 2229 53 14 0.264150943396226 0.00628084342754599
GO:CC GO:0030133 transport vesicle 0.0159530841371375 414 109 8 0.073394495412844 0.0193236714975845
GO:CC GO:0098791 Golgi apparatus subcompartment 0.0162485789290056 885 143 15 0.104895104895105 0.0169491525423729
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0162485789290056 11296 104 76 0.730769230769231 0.00672804532577904
GO:CC GO:0071944 cell periphery 0.0173114997365924 6169 18 12 0.666666666666667 0.00194520992057059
GO:CC GO:0044853 plasma membrane raft 0.0173711698734401 116 99 4 0.0404040404040404 0.0344827586206897
GO:CC GO:0016020 membrane 0.0182315310390225 9838 109 71 0.651376146788991 0.00721691400691197
GO:CC GO:0042995 cell projection 0.020433998818003 2330 53 14 0.264150943396226 0.00600858369098712
GO:CC GO:0070161 anchoring junction 0.0206306124402212 836 127 13 0.102362204724409 0.0155502392344498
GO:CC GO:0042579 microbody 0.022362201570264 141 90 4 0.0444444444444444 0.0283687943262411
GO:CC GO:0005777 peroxisome 0.022362201570264 141 90 4 0.0444444444444444 0.0283687943262411
GO:CC GO:0016324 apical plasma membrane 0.0229356895510044 361 137 8 0.0583941605839416 0.0221606648199446
GO:CC GO:0005770 late endosome 0.0240382997096458 275 109 6 0.055045871559633 0.0218181818181818
GO:CC GO:0031301 integral component of organelle membrane 0.0240382997096458 382 104 7 0.0673076923076923 0.0183246073298429
GO:CC GO:1904813 ficolin-1-rich granule lumen 0.0240382997096458 124 106 4 0.0377358490566038 0.032258064516129
GO:CC GO:0005740 mitochondrial envelope 0.02536842366478 797 108 11 0.101851851851852 0.013801756587202
GO:CC GO:0031984 organelle subcompartment 0.02536842366478 1773 109 19 0.174311926605505 0.0107163000564016
GO:CC GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 0.02536842366478 131 103 4 0.0388349514563107 0.0305343511450382
GO:CC GO:0005886 plasma membrane 0.0261979982486778 5681 18 11 0.611111111111111 0.00193627882415068
GO:CC GO:0005759 mitochondrial matrix 0.0269514047277444 479 66 6 0.0909090909090909 0.0125260960334029
GO:CC GO:0012506 vesicle membrane 0.027649701263812 800 125 12 0.096 0.015
GO:CC GO:0030665 clathrin-coated vesicle membrane 0.0281745986272636 114 125 4 0.032 0.0350877192982456
GO:CC GO:0031968 organelle outer membrane 0.0291996022929889 227 102 5 0.0490196078431373 0.0220264317180617
GO:CC GO:0001725 stress fiber 0.0291996022929889 68 112 3 0.0267857142857143 0.0441176470588235
GO:CC GO:0030054 cell junction 0.0291996022929889 2105 17 6 0.352941176470588 0.00285035629453682
GO:CC GO:0097517 contractile actin filament bundle 0.0291996022929889 68 112 3 0.0267857142857143 0.0441176470588235
GO:CC GO:1904724 tertiary granule lumen 0.0291996022929889 55 140 3 0.0214285714285714 0.0545454545454545
GO:CC GO:0031300 intrinsic component of organelle membrane 0.0291996022929889 413 104 7 0.0673076923076923 0.0169491525423729
GO:CC GO:0019867 outer membrane 0.0294078811710001 229 102 5 0.0490196078431373 0.0218340611353712
GO:CC GO:0045335 phagocytic vesicle 0.0296565430377765 137 109 4 0.036697247706422 0.0291970802919708
GO:CC GO:0005794 Golgi apparatus 0.0304648345523916 1623 123 19 0.154471544715447 0.0117067159581023
GO:CC GO:0005829 cytosol 0.0317544554220797 5303 117 45 0.384615384615385 0.00848576277578729
GO:CC GO:0030136 clathrin-coated vesicle 0.0321596069068263 193 125 5 0.04 0.0259067357512953
GO:CC GO:0031967 organelle envelope 0.0363591466741129 1237 108 14 0.12962962962963 0.0113177041228779
GO:CC GO:0031975 envelope 0.0363591466741129 1237 108 14 0.12962962962963 0.0113177041228779
GO:CC GO:0042641 actomyosin 0.0365608068735395 77 112 3 0.0267857142857143 0.038961038961039
GO:CC GO:0005775 vacuolar lumen 0.0394098072204235 174 52 3 0.0576923076923077 0.0172413793103448
GO:CC GO:0032592 integral component of mitochondrial membrane 0.0394314124305427 89 102 3 0.0294117647058824 0.0337078651685393
GO:CC GO:0098573 intrinsic component of mitochondrial membrane 0.0402987127003754 90 102 3 0.0294117647058824 0.0333333333333333
GO:CC GO:0030135 coated vesicle 0.0423484404587013 295 125 6 0.048 0.0203389830508475
GO:CC GO:0098857 membrane microdomain 0.0424078170448026 335 53 4 0.0754716981132075 0.0119402985074627
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.0424078170448026 779 125 11 0.088 0.0141206675224647
GO:CC GO:0045121 membrane raft 0.0424078170448026 335 53 4 0.0754716981132075 0.0119402985074627
GO:CC GO:0000139 Golgi membrane 0.0424078170448026 771 143 12 0.0839160839160839 0.0155642023346304
GO:CC GO:0005802 trans-Golgi network 0.0437121237645818 250 109 5 0.0458715596330275 0.02
GO:MF GO:0051015 actin filament binding 0.000189459993444141 212 58 8 0.137931034482759 0.0377358490566038
GO:MF GO:0030165 PDZ domain binding 0.000398251445989216 89 114 7 0.0614035087719298 0.0786516853932584
GO:MF GO:0003779 actin binding 0.00111556800835266 448 58 9 0.155172413793103 0.0200892857142857
GO:MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 0.00111556800835266 137 40 5 0.125 0.0364963503649635
GO:MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.00111556800835266 125 40 5 0.125 0.04
GO:MF GO:0016836 hydro-lyase activity 0.00111556800835266 65 87 5 0.0574712643678161 0.0769230769230769
GO:MF GO:0003824 catalytic activity 0.00126431622208973 5896 88 47 0.534090909090909 0.00797150610583446
GO:MF GO:0016788 hydrolase activity, acting on ester bonds 0.0013487467255719 773 10 5 0.5 0.00646830530401035
GO:MF GO:0008092 cytoskeletal protein binding 0.0013487467255719 996 112 18 0.160714285714286 0.0180722891566265
GO:MF GO:0044877 protein-containing complex binding 0.0013487467255719 1287 58 14 0.241379310344828 0.0108780108780109
GO:MF GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0013487467255719 30 38 3 0.0789473684210526 0.1
GO:MF GO:0033293 monocarboxylic acid binding 0.0013487467255719 74 86 5 0.0581395348837209 0.0675675675675676
GO:MF GO:0008514 organic anion transmembrane transporter activity 0.0013487467255719 187 120 8 0.0666666666666667 0.0427807486631016
GO:MF GO:0016835 carbon-oxygen lyase activity 0.00157698278216301 81 87 5 0.0574712643678161 0.0617283950617284
GO:MF GO:0016229 steroid dehydrogenase activity 0.00190504918834157 35 38 3 0.0789473684210526 0.0857142857142857
GO:MF GO:0005215 transporter activity 0.00338157103213326 1185 123 20 0.16260162601626 0.0168776371308017
GO:MF GO:0008509 anion transmembrane transporter activity 0.00391942661121325 464 61 8 0.131147540983607 0.0172413793103448
GO:MF GO:0098531 ligand-activated transcription factor activity 0.00394592002263454 54 92 4 0.0434782608695652 0.0740740740740741
GO:MF GO:0004879 nuclear receptor activity 0.00394592002263454 54 92 4 0.0434782608695652 0.0740740740740741
GO:MF GO:0015291 secondary active transmembrane transporter activity 0.00394592002263454 237 120 8 0.0666666666666667 0.0337552742616034
GO:MF GO:0022804 active transmembrane transporter activity 0.00475476547440736 312 120 9 0.075 0.0288461538461538
GO:MF GO:0043168 anion binding 0.00482993492423053 2418 114 29 0.254385964912281 0.0119933829611249
GO:MF GO:0043167 ion binding 0.00578282287427823 6057 119 57 0.478991596638655 0.00941059930658742
GO:MF GO:0005200 structural constituent of cytoskeleton 0.00578282287427823 104 24 3 0.125 0.0288461538461538
GO:MF GO:0019904 protein domain specific binding 0.00690026900201037 710 114 13 0.114035087719298 0.0183098591549296
GO:MF GO:0005548 phospholipid transporter activity 0.00820372437168669 56 123 4 0.032520325203252 0.0714285714285714
GO:MF GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 0.0092773737505944 65 110 4 0.0363636363636364 0.0615384615384615
GO:MF GO:0051287 NAD binding 0.00975074215369686 55 136 4 0.0294117647058824 0.0727272727272727
GO:MF GO:0005504 fatty acid binding 0.0109725357101651 40 86 3 0.0348837209302326 0.075
GO:MF GO:0016787 hydrolase activity 0.0109725357101651 2615 13 7 0.538461538461538 0.00267686424474187
GO:MF GO:0036094 small molecule binding 0.0112588745938677 2506 114 28 0.245614035087719 0.0111731843575419
GO:MF GO:0000166 nucleotide binding 0.0118544132547962 2171 39 12 0.307692307692308 0.00552740672501152
GO:MF GO:1901265 nucleoside phosphate binding 0.0118544132547962 2172 39 12 0.307692307692308 0.00552486187845304
GO:MF GO:0045296 cadherin binding 0.0118544132547962 333 12 3 0.25 0.00900900900900901
GO:MF GO:0005342 organic acid transmembrane transporter activity 0.0132438538182127 154 61 4 0.0655737704918033 0.025974025974026
GO:MF GO:0022857 transmembrane transporter activity 0.0132438538182127 1075 120 16 0.133333333333333 0.0148837209302326
GO:MF GO:0015932 nucleobase-containing compound transmembrane transporter activity 0.0132438538182127 68 61 3 0.0491803278688525 0.0441176470588235
GO:MF GO:0015297 antiporter activity 0.0132438538182127 84 108 4 0.037037037037037 0.0476190476190476
GO:MF GO:0046943 carboxylic acid transmembrane transporter activity 0.0132438538182127 153 61 4 0.0655737704918033 0.0261437908496732
GO:MF GO:0016491 oxidoreductase activity 0.0132438538182127 771 137 14 0.102189781021898 0.0181582360570687
GO:MF GO:0005496 steroid binding 0.0132438538182127 100 92 4 0.0434782608695652 0.04
GO:MF GO:0008289 lipid binding 0.0132438538182127 776 92 11 0.119565217391304 0.0141752577319588
GO:MF GO:1901505 carbohydrate derivative transmembrane transporter activity 0.0135166613804346 72 61 3 0.0491803278688525 0.0416666666666667
GO:MF GO:0031406 carboxylic acid binding 0.0147294365239733 194 86 5 0.0581395348837209 0.0257731958762887
GO:MF GO:0043621 protein self-association 0.0156929803191999 56 86 3 0.0348837209302326 0.0535714285714286
GO:MF GO:0004857 enzyme inhibitor activity 0.0172507796329553 385 28 4 0.142857142857143 0.0103896103896104
GO:MF GO:0016829 lyase activity 0.017789549146885 203 87 5 0.0574712643678161 0.0246305418719212
GO:MF GO:0046872 metal ion binding 0.0197550482775505 4260 6 5 0.833333333333333 0.00117370892018779
GO:MF GO:0016779 nucleotidyltransferase activity 0.0205217472126473 135 84 4 0.0476190476190476 0.0296296296296296
GO:MF GO:0043169 cation binding 0.0205891878602183 4351 6 5 0.833333333333333 0.00114916111238796
GO:MF GO:0046914 transition metal ion binding 0.0209769065047331 1111 6 3 0.5 0.0027002700270027
GO:MF GO:0042803 protein homodimerization activity 0.0221719659920946 676 138 12 0.0869565217391304 0.0177514792899408
GO:MF GO:0050839 cell adhesion molecule binding 0.0223299553244436 546 12 3 0.25 0.00549450549450549
GO:MF GO:0004712 protein serine/threonine/tyrosine kinase activity 0.0223872988138777 44 142 3 0.0211267605633803 0.0681818181818182
GO:MF GO:0005319 lipid transporter activity 0.0240608352223752 167 123 5 0.040650406504065 0.029940119760479
GO:MF GO:0005509 calcium ion binding 0.0259149484707513 721 31 5 0.161290322580645 0.00693481276005548
GO:MF GO:0016746 transferase activity, transferring acyl groups 0.0294689416048974 261 87 5 0.0574712643678161 0.0191570881226054
GO:MF GO:0008028 monocarboxylic acid transmembrane transporter activity 0.030481125205426 69 111 3 0.027027027027027 0.0434782608695652
GO:MF GO:0017022 myosin binding 0.0311603578589372 72 109 3 0.0275229357798165 0.0416666666666667
GO:MF GO:0042802 identical protein binding 0.0319176144251892 2067 138 25 0.181159420289855 0.0120948234155781
GO:MF GO:0019902 phosphatase binding 0.0343071296638112 198 124 5 0.0403225806451613 0.0252525252525253
GO:MF GO:0050660 flavin adenine dinucleotide binding 0.040089701299285 83 110 3 0.0272727272727273 0.036144578313253
GO:MF GO:0032553 ribonucleotide binding 0.044814272912938 1935 39 9 0.230769230769231 0.00465116279069767
GO:MF GO:0016462 pyrophosphatase activity 0.0492850477554246 928 123 12 0.0975609756097561 0.0129310344827586
GO:MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0496503760664863 930 123 12 0.0975609756097561 0.0129032258064516
GO:MF GO:0016817 hydrolase activity, acting on acid anhydrides 0.0496503760664863 930 123 12 0.0975609756097561 0.0129032258064516
HPA HPA:0030053 appendix; glandular cells[High] 5.50123292433089e-07 1986 111 48 0.432432432432432 0.0241691842900302
HPA HPA:0400053 rectum; glandular cells[High] 6.6001829955424e-06 2687 104 52 0.5 0.019352437662821
HPA HPA:0150053 duodenum; glandular cells[High] 3.2991916135308e-05 2767 112 54 0.482142857142857 0.0195157209974702
HPA HPA:0480053 small intestine; glandular cells[High] 0.000308750646022221 2723 110 50 0.454545454545455 0.0183621006243114
HPA HPA:0130053 colon; glandular cells[High] 0.000308750646022221 2538 111 48 0.432432432432432 0.0189125295508274
HPA HPA:0381212 placenta; syncytiotrophoblasts - cell body[≥Medium] 0.00768680601459493 327 77 10 0.12987012987013 0.0305810397553517
HPA HPA:0381213 placenta; syncytiotrophoblasts - cell body[High] 0.0126980973525436 231 77 8 0.103896103896104 0.0346320346320346
HPA HPA:0400052 rectum; glandular cells[≥Medium] 0.0126980973525436 6410 21 20 0.952380952380952 0.0031201248049922
HPA HPA:0290403 liver; hepatocytes[High] 0.0126980973525436 839 110 20 0.181818181818182 0.0238379022646007
HPA HPA:0381211 placenta; syncytiotrophoblasts - cell body[≥Low] 0.0126980973525436 370 77 10 0.12987012987013 0.027027027027027
HPA HPA:0030052 appendix; glandular cells[≥Medium] 0.0292382992833457 5767 117 80 0.683760683760684 0.0138720305184671
HPA HPA:0381202 placenta; hofbauer cells[≥Medium] 0.0292382992833457 213 77 7 0.0909090909090909 0.0328638497652582
HPA HPA:0130052 colon; glandular cells[≥Medium] 0.0302331337562664 6278 117 85 0.726495726495726 0.0135393437400446
HPA HPA:0210852 fallopian tube; ciliated cells (cell body)[≥Medium] 0.0324415218256629 372 139 13 0.0935251798561151 0.0349462365591398
HPA HPA:0381221 placenta; syncytiotrophoblasts - microvilli[≥Low] 0.0467834830968856 240 77 7 0.0909090909090909 0.0291666666666667
KEGG KEGG:05216 Thyroid cancer 7.89665998151714e-05 37 102 7 0.0686274509803922 0.189189189189189
KEGG KEGG:00920 Sulfur metabolism 0.000159112270483502 10 19 3 0.157894736842105 0.3
KEGG KEGG:01212 Fatty acid metabolism 0.00950890764352953 57 110 6 0.0545454545454545 0.105263157894737
KEGG KEGG:00071 Fatty acid degradation 0.0167959099987488 43 110 5 0.0454545454545455 0.116279069767442
KEGG KEGG:00040 Pentose and glucuronate interconversions 0.0293679421988879 34 40 3 0.075 0.0882352941176471
KEGG KEGG:00640 Propanoate metabolism 0.0449005511153288 34 110 4 0.0363636363636364 0.117647058823529
MIRNA MIRNA:hsa-miR-6511a-5p hsa-miR-6511a-5p 0.0292540839138865 498 91 12 0.131868131868132 0.0240963855421687
MIRNA MIRNA:hsa-miR-3074-3p hsa-miR-3074-3p 0.0292540839138865 59 19 3 0.157894736842105 0.0508474576271186
MIRNA MIRNA:hsa-miR-1-3p hsa-miR-1-3p 0.0292540839138865 915 124 20 0.161290322580645 0.0218579234972678
MIRNA MIRNA:hsa-miR-1910-3p hsa-miR-1910-3p 0.0292540839138865 495 91 12 0.131868131868132 0.0242424242424242
MIRNA MIRNA:hsa-miR-670-3p hsa-miR-670-3p 0.0292540839138865 196 55 6 0.109090909090909 0.0306122448979592
REAC REAC:R-HSA-1430728 Metabolism 1.91852976296987e-05 2070 92 41 0.445652173913043 0.0198067632850242
REAC REAC:R-HSA-173599 Formation of the active cofactor, UDP-glucuronate 1.91852976296987e-05 3 45 3 0.0666666666666667 1
REAC REAC:R-HSA-156580 Phase II - Conjugation of compounds 0.000836238889260176 104 45 6 0.133333333333333 0.0576923076923077
REAC REAC:R-HSA-211859 Biological oxidations 0.00169749117221464 215 56 8 0.142857142857143 0.0372093023255814
REAC REAC:R-HSA-156584 Cytosolic sulfonation of small molecules 0.00620314400735049 23 43 3 0.0697674418604651 0.130434782608696
REAC REAC:R-HSA-156588 Glucuronidation 0.00640103816997044 23 45 3 0.0666666666666667 0.130434782608696
REAC REAC:R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.00861615554179745 31 39 3 0.0769230769230769 0.0967741935483871
REAC REAC:R-HSA-383280 Nuclear Receptor transcription pathway 0.0133420139184785 41 92 4 0.0434782608695652 0.0975609756097561
REAC REAC:R-HSA-556833 Metabolism of lipids 0.0143399349224106 730 110 18 0.163636363636364 0.0246575342465753
REAC REAC:R-HSA-1630316 Glycosaminoglycan metabolism 0.0314379074512126 123 19 3 0.157894736842105 0.024390243902439
REAC REAC:R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 0.0412458096294166 35 77 3 0.038961038961039 0.0857142857142857
REAC REAC:R-HSA-71387 Metabolism of carbohydrates 0.0412458096294166 285 21 4 0.19047619047619 0.0140350877192982
REAC REAC:R-HSA-8978868 Fatty acid metabolism 0.0412458096294166 173 110 7 0.0636363636363636 0.0404624277456647
REAC REAC:R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle 0.0414432161000711 54 111 4 0.036036036036036 0.0740740740740741
REAC REAC:R-HSA-975634 Retinoid metabolism and transport 0.0442423636060962 44 69 3 0.0434782608695652 0.0681818181818182
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 0.0496228328641167 368 19 4 0.210526315789474 0.0108695652173913
REAC REAC:R-HSA-6806667 Metabolism of fat-soluble vitamins 0.0496228328641167 48 69 3 0.0434782608695652 0.0625
TF TF:M09896_1 Factor: E2F-7; motif: GRGGCGGGAANNN; match class: 1 0.00575167796506113 4525 138 56 0.405797101449275 0.0123756906077348
TF TF:M01047 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT 0.00575167796506113 9237 95 67 0.705263157894737 0.00725343726318069
TF TF:M01047_1 Factor: AP-2alphaA; motif: ANMGCCTNAGGCKNT; match class: 1 0.00575167796506113 9237 95 67 0.705263157894737 0.00725343726318069
TF TF:M00695 Factor: ETF; motif: GVGGMGG 0.00575167796506113 10430 136 98 0.720588235294118 0.00939597315436242
TF TF:M05332 Factor: Sp2; motif: WGGGCGG 0.0181417873265575 8578 103 66 0.640776699029126 0.00769410118908837
TF TF:M05386 Factor: KLF17; motif: NGGGCGG 0.0181417873265575 7900 142 81 0.570422535211268 0.010253164556962
TF TF:M10098_1 Factor: DP-1; motif: NRNNGGCGGGAANN; match class: 1 0.0181417873265575 2168 118 29 0.245762711864407 0.0133763837638376
TF TF:M10432_1 Factor: MAZ; motif: GGGMGGGGS; match class: 1 0.0181417873265575 4365 122 47 0.385245901639344 0.0107674684994273
TF TF:M05361 Factor: Sp6; motif: WGGGCGG 0.0181417873265575 8578 103 66 0.640776699029126 0.00769410118908837
TF TF:M05444 Factor: CPBP; motif: NGGGCGG 0.0181417873265575 8578 103 66 0.640776699029126 0.00769410118908837
TF TF:M05499 Factor: LKLF; motif: NGGGCGG 0.0181417873265575 7900 142 81 0.570422535211268 0.010253164556962
TF TF:M07367 Factor: Slug; motif: SSSNNNKCACCTGN 0.0220472376114631 1680 124 25 0.201612903225806 0.0148809523809524
TF TF:M09808 Factor: KLF4; motif: MCACACCCTNN 0.0287426045069597 3799 126 43 0.341269841269841 0.0113187680968676
TF TF:M08487_1 Factor: GCMa:Erg; motif: ATGCGGGCGGAARKG; match class: 1 0.029938518987885 8790 138 84 0.608695652173913 0.00955631399317406
TF TF:M11840 Factor: ERR3; motif: NNSAAGGTCRN 0.029938518987885 1116 125 19 0.152 0.0170250896057348
TF TF:M02098 Factor: LRH-1; motif: NNYCAAGGYYN 0.029938518987885 3000 116 34 0.293103448275862 0.0113333333333333
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.029938518987885 9362 138 88 0.63768115942029 0.00939970091860714
TF TF:M07380_1 Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 0.0299511280486447 7965 34 25 0.735294117647059 0.00313873195229127
TF TF:M03846 Factor: SMAD5; motif: GSGGCAGM 0.0299511280486447 8552 34 26 0.764705882352941 0.00304022450888681
TF TF:M00144 Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM 0.0316385275789897 13205 108 90 0.833333333333333 0.00681560015145778
TF TF:M09908 Factor: ERR1; motif: NYCAAGGTCANNNNN 0.0350874658322392 1055 125 18 0.144 0.0170616113744076
TF TF:M01972 Factor: EGR-1; motif: TGCGTGGGCGK 0.0354512771013879 5360 101 45 0.445544554455446 0.0083955223880597
TF TF:M00922 Factor: SRF; motif: CCAWATAWGGMNMNG 0.0354512771013879 291 35 5 0.142857142857143 0.0171821305841924
TF TF:M01199 Factor: RNF96; motif: BCCCGCRGCC 0.0354512771013879 8473 109 66 0.605504587155963 0.00778944883748377
TF TF:M07387_1 Factor: LRF; motif: NGKGGGTSNCN; match class: 1 0.0354512771013879 1040 39 9 0.230769230769231 0.00865384615384615
TF TF:M07289_1 Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1 0.0354512771013879 10555 136 94 0.691176470588235 0.0089057318806253
TF TF:M07084_1 Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 0.0354512771013879 5437 100 45 0.45 0.00827662313775979
TF TF:M11839 Factor: ERR3; motif: NNSAAGGTCAN 0.0354512771013879 1371 116 20 0.172413793103448 0.0145878920495988
TF TF:M11490 Factor: LBP-1; motif: NRCCGGTNNNNACCGGYN 0.0354512771013879 6748 128 64 0.5 0.00948429164196799
TF TF:M01835 Factor: GKLF; motif: CCTCCYN 0.0375707877073648 15620 37 37 1 0.00236875800256082
TF TF:M09895_1 Factor: E2F-6; motif: NGGGCGGGARRNN; match class: 1 0.0375707877073648 2711 122 32 0.262295081967213 0.0118037624492807
TF TF:M04385 Factor: LHX2; motif: NCTAATTANN 0.0391717303369691 900 56 10 0.178571428571429 0.0111111111111111
TF TF:M12169 Factor: AP-2rep; motif: RGCCGACGCCCN 0.039677042229876 176 33 4 0.121212121212121 0.0227272727272727
TF TF:M01132 Factor: SF-1; motif: TGACCTTGN 0.0415666617098089 1534 116 21 0.181034482758621 0.0136897001303781
TF TF:M01303 Factor: SP1; motif: GGGGYGGGGNS 0.0425482909981834 7898 138 76 0.550724637681159 0.00962268928842745
TF TF:M11490_1 Factor: LBP-1; motif: NRCCGGTNNNNACCGGYN; match class: 1 0.0425482909981834 5988 128 58 0.453125 0.00968603874415498
TF TF:M00244 Factor: NGFI-C; motif: WTGCGTGGGYGG 0.0425482909981834 6184 132 61 0.462121212121212 0.00986416558861578
TF TF:M12354_1 Factor: ZNF37A; motif: CCYYGGCTCCNTSCCMN; match class: 1 0.0425482909981834 5624 127 55 0.433070866141732 0.00977951635846373
TF TF:M01253 Factor: CNOT3; motif: GGCCGCGSSS 0.0428959998469801 3926 53 22 0.415094339622642 0.00560366785532348
TF TF:M12140 Factor: Egr-1; motif: NNCRCCCMCGCNN 0.0440650597987133 5360 133 55 0.413533834586466 0.0102611940298507
TF TF:M09892_1 Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 0.0468322434682566 9162 29 23 0.793103448275862 0.00251036891508404
TF TF:M11883 Factor: pax-6; motif: NYACGCNTSRNYGCNYN 0.0468322434682566 13445 136 111 0.816176470588235 0.00825585719598364
TF TF:M11601_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.0468322434682566 11053 139 98 0.705035971223022 0.00886637112096264
TF TF:M07289 Factor: GKLF; motif: NNNRGGNGNGGSN 0.0474087329608903 14646 63 58 0.920634920634921 0.00396012563157176
TF TF:M07402 Factor: ESRRA; motif: YCAAGGTCACN 0.0475624671205694 1698 116 22 0.189655172413793 0.0129564193168433

pEpi16 transcription factor target enrichment of top program genes

TF enrichment of pEpi16
Possible regulators of activation of pEpi16 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.