pEpiTp23 program activity among Epithelial cells

Activation of pEpiTp23
pEpiTp23 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp23 by different cell subtypes
pEpiTp23 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp23 top program genes

Top genes of pEpiTp23 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp23 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp23
pEpiTp23 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
TF TF:M11435_1 Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 0.00131224340243127 5745 132 66 0.5 0.0114882506527415
TF TF:M11603_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.00131224340243127 13184 97 86 0.88659793814433 0.00652305825242718
TF TF:M04515 Factor: E2F-1; motif: WWTGGCGCCAAA 0.00131224340243127 13334 128 111 0.8671875 0.00832458377081146
TF TF:M11435 Factor: Elk-1; motif: NNCCGGAAGTN 0.00164458643840147 11728 136 107 0.786764705882353 0.00912346521145975
TF TF:M09765 Factor: SP1; motif: NRGKGGGCGGGGCN 0.00164458643840147 7469 87 55 0.632183908045977 0.00736377025036819
TF TF:M01660_1 Factor: GABP-alpha; motif: CTTCCK; match class: 1 0.00164458643840147 5133 136 61 0.448529411764706 0.0118838885641925
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.00325650647821494 14873 131 119 0.908396946564885 0.0080010757748941
TF TF:M01660 Factor: GABP-alpha; motif: CTTCCK 0.00325650647821494 11116 136 102 0.75 0.00917596257646635
TF TF:M00716 Factor: ZF5; motif: GSGCGCGR 0.00325650647821494 16103 136 129 0.948529411764706 0.00801092964043967
TF TF:M08526_1 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 0.00325650647821494 14997 136 124 0.911764705882353 0.00826832033073281
TF TF:M11533 Factor: E2F-1; motif: NTTTTGGCGCCAWWWN 0.00325650647821494 13105 128 108 0.84375 0.00824112933994658
TF TF:M04515_1 Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 0.0038160866182866 12173 128 102 0.796875 0.00837919986856157
TF TF:M02090 Factor: E2F-4; motif: GCGGGAAANA 0.0038160866182866 11966 108 87 0.805555555555556 0.00727060003342805
TF TF:M02090_1 Factor: E2F-4; motif: GCGGGAAANA; match class: 1 0.0038160866182866 6378 108 57 0.527777777777778 0.00893697083725306
TF TF:M12158 Factor: KLF15; motif: NCCMCGCCCMCN 0.0038160866182866 11088 125 94 0.752 0.00847763347763348
TF TF:M04823 Factor: E2F-4; motif: NNTTCCCGCCNN 0.0038160866182866 12747 125 103 0.824 0.00808033262728485
TF TF:M08377 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN 0.00416167851940767 11275 136 102 0.75 0.00904656319290466
TF TF:M08525_1 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 0.00436028306110595 15268 97 91 0.938144329896907 0.00596017815037988
TF TF:M10530 Factor: sp4; motif: NNNGCYCCGCCCCCY 0.00436028306110595 8227 127 77 0.606299212598425 0.00935942627932418
TF TF:M08205 Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT 0.00462480378209768 14429 136 120 0.882352941176471 0.00831658465590131
TF TF:M08226 Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG 0.00473065136059816 12039 127 100 0.78740157480315 0.00830633773569233
TF TF:M07206_1 Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 0.00528830214395772 10849 109 81 0.743119266055046 0.00746612591022214
TF TF:M08526 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN 0.00528830214395772 16867 128 124 0.96875 0.00735163336692951
TF TF:M03920 Factor: SP1; motif: RCCMCRCCCMC 0.00528830214395772 7283 131 72 0.549618320610687 0.00988603597418646
TF TF:M08206_1 Factor: E2F-3:Prrxl1; motif: SGCGCTAATTNN; match class: 1 0.00528830214395772 5052 133 56 0.421052631578947 0.0110847189231987
TF TF:M11535_1 Factor: E2F-4; motif: TTTTGGCGCCAWWN; match class: 1 0.00528830214395772 6532 135 68 0.503703703703704 0.0104102878138396
TF TF:M00025 Factor: Elk-1; motif: NNNNCCGGAARTNN 0.00528830214395772 10262 133 93 0.699248120300752 0.00906256090430715
TF TF:M11530 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN 0.00528830214395772 14593 128 114 0.890625 0.0078119646405811
TF TF:M00933 Factor: Sp1; motif: CCCCGCCCCN 0.00528830214395772 9715 97 68 0.701030927835051 0.00699948533196089
TF TF:M11530_1 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 0.00528830214395772 13449 128 108 0.84375 0.00803033682801695
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.00621785103650115 10640 97 72 0.742268041237113 0.00676691729323308
TF TF:M11529 Factor: E2F-2; motif: GCGCGCGCNCS 0.00621785103650115 16263 131 124 0.946564885496183 0.00762466949517309
TF TF:M04516_1 Factor: E2F-1; motif: TTTGGCGCCAAA; match class: 1 0.0063376188512766 10227 128 89 0.6953125 0.00870245428766989
TF TF:M04516 Factor: E2F-1; motif: TTTGGCGCCAAA 0.0063376188512766 11383 128 96 0.75 0.00843362909602038
TF TF:M11535 Factor: E2F-4; motif: TTTTGGCGCCAWWN 0.0063376188512766 10884 128 93 0.7265625 0.00854465270121279
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.0063376188512766 10233 97 70 0.721649484536082 0.00684061370077201
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 0.00656517904375029 13929 128 110 0.859375 0.00789719290688492
TF TF:M11434 Factor: Elk-1; motif: NRSCGGAAGNN 0.00672021254710576 8219 136 80 0.588235294117647 0.00973354422679158
TF TF:M00716_1 Factor: ZF5; motif: GSGCGCGR; match class: 1 0.00795013460037946 14106 136 117 0.860294117647059 0.00829434283283709
TF TF:M01243_1 Factor: MTF-1; motif: TGCGCAC; match class: 1 0.00824203268682475 731 3 3 1 0.00410396716826265
TF TF:M03896_1 Factor: EGR1; motif: NACGCCCACGCANW; match class: 1 0.0106156765968503 2106 74 20 0.27027027027027 0.00949667616334283
TF TF:M12151 Factor: Sp1; motif: NWRGCCMCGCCCMCN 0.0106156765968503 6821 131 67 0.511450381679389 0.00982260665591556
TF TF:M00803 Factor: E2F; motif: GGCGSG 0.0110031142666971 13190 84 72 0.857142857142857 0.00545868081880212
TF TF:M10098 Factor: DP-1; motif: NRNNGGCGGGAANN 0.0110031142666971 7015 135 70 0.518518518518518 0.00997861724875267
TF TF:M11531 Factor: E2F-2; motif: GCGCGCGCGYW 0.0118676241684429 13270 89 76 0.853932584269663 0.00572720422004522
TF TF:M01588 Factor: GKLF; motif: GCCMCRCCCNNN 0.0118676241684429 8944 136 84 0.617647058823529 0.009391771019678
TF TF:M02065 Factor: ER81; motif: RCCGGAARYN 0.0123145758086427 12550 136 107 0.786764705882353 0.00852589641434263
TF TF:M11601_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.0123145758086427 11053 84 64 0.761904761904762 0.00579028318103682
TF TF:M05439 Factor: RREB-1; motif: GGGWCSA 0.0123145758086427 8635 93 59 0.634408602150538 0.0068326577880718
TF TF:M10575 Factor: Gbx2; motif: NTCRTTAN 0.0123145758086427 2224 112 27 0.241071428571429 0.0121402877697842
TF TF:M01240 Factor: BEN; motif: CAGCGRNV 0.0123145758086427 16498 79 77 0.974683544303797 0.00466723239180507
TF TF:M03807 Factor: SP2; motif: GNNGGGGGCGGGGSN 0.0123145758086427 8415 97 60 0.618556701030928 0.0071301247771836
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.0123145758086427 10281 97 69 0.711340206185567 0.00671140939597315
TF TF:M11430 Factor: PEA3; motif: NACCGGAAGTN 0.0123145758086427 10865 135 96 0.711111111111111 0.00883571099861942
TF TF:M00008 Factor: Sp1; motif: GGGGCGGGGT 0.0123145758086427 10055 87 62 0.71264367816092 0.00616608652411735
TF TF:M10071 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG 0.0132618052158245 8495 87 55 0.632183908045977 0.0064743967039435
TF TF:M08225_1 Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 0.0132618052158245 7993 126 72 0.571428571428571 0.00900788189665958
TF TF:M09967 Factor: AP-2rep; motif: NGGGGCGGGGC 0.0134898848458362 4023 127 44 0.346456692913386 0.0109371116082525
TF TF:M10683 Factor: HOXB7; motif: GTCRTTAN 0.0134898848458362 1643 112 22 0.196428571428571 0.0133901399878271
TF TF:M09892 Factor: E2F-1; motif: NNNNGGCGGGAARN 0.0134898848458362 13528 109 92 0.844036697247706 0.00680070963926671
TF TF:M01171_1 Factor: BCL6; motif: NKTTCTAGGW; match class: 1 0.0140366766131839 52 38 3 0.0789473684210526 0.0576923076923077
TF TF:M02059 Factor: ELK-1; motif: ACCGGAAGTN 0.0140366766131839 9423 135 86 0.637037037037037 0.0091266051151438
TF TF:M01821 Factor: c-Myb; motif: NNNAACKGNNN 0.0140366766131839 4258 10 8 0.8 0.00187881634570221
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 0.0147368834131464 14473 109 96 0.880733944954128 0.00663304083465764
TF TF:M04826_1 Factor: p300; motif: ACNTCCG; match class: 1 0.0150989124998336 15260 136 122 0.897058823529412 0.00799475753604194
TF TF:M03852_1 Factor: SREBP-2; motif: NTCACCYNNNN; match class: 1 0.0150989124998336 2246 24 10 0.416666666666667 0.00445235975066785
TF TF:M12160 Factor: KLF15; motif: RCCMCRCCCMCN 0.0153777348101702 12729 127 101 0.795275590551181 0.00793463744206143
TF TF:M09904 Factor: Elk-1; motif: RCCGGAAGTGN 0.0153777348101702 8164 135 77 0.57037037037037 0.00943165115139637
TF TF:M11022_1 Factor: IRX2a; motif: ACRYGNNNNACRYGT; match class: 1 0.0153777348101702 6246 132 62 0.46969696969697 0.00992635286583413
TF TF:M08226_1 Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 0.0153777348101702 5604 123 54 0.439024390243902 0.00963597430406852
TF TF:M00017 Factor: ATF; motif: CNSTGACGTNNNYC 0.0153777348101702 7226 132 69 0.522727272727273 0.00954885137005259
TF TF:M08441_1 Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 0.0161930355874468 12761 109 88 0.807339449541284 0.0068960112843821
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.0161930355874468 6260 127 60 0.47244094488189 0.00958466453674121
TF TF:M08225 Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG 0.0163937357020049 14039 127 108 0.850393700787402 0.0076928556164969
TF TF:M10438 Factor: ZF5; motif: GGSGCGCGS 0.0174804552551014 16228 97 92 0.948453608247423 0.00566921370470791
TF TF:M11448 Factor: Elf-1; motif: NANGCGGAAGTN 0.0174804552551014 7600 136 73 0.536764705882353 0.00960526315789474
TF TF:M01857 Factor: AP-2alpha; motif: NGCCYSNNGSN 0.0174804552551014 9178 55 39 0.709090909090909 0.00424929178470255
TF TF:M11424 Factor: Erm; motif: NNSCGGAWGYN 0.0174804552551014 8149 136 77 0.566176470588235 0.0094490121487299
TF TF:M11022 Factor: IRX2a; motif: ACRYGNNNNACRYGT 0.0174804552551014 9487 132 84 0.636363636363636 0.00885422156635396
TF TF:M08487 Factor: GCMa:Erg; motif: ATGCGGGCGGAARKG 0.0174804552551014 13942 128 108 0.84375 0.0077463778510974
TF TF:M00122 Factor: USF; motif: NNRNCACGTGNYNN 0.0174804552551014 2413 4 4 1 0.00165768752590137
TF TF:M04918 Factor: Egr-1; motif: ACCGCCC 0.0174804552551014 5608 39 22 0.564102564102564 0.00392296718972896
TF TF:M10435 Factor: Sp2; motif: GGGGCGGGG 0.0174804552551014 7696 88 51 0.579545454545455 0.00662681912681913
TF TF:M07206 Factor: E2F-1; motif: NGGGCGGGARV 0.0174804552551014 14575 125 109 0.872 0.00747855917667238
TF TF:M00938 Factor: E2F-1; motif: TTGGCGCGRAANNGNM 0.0174804552551014 7334 127 67 0.52755905511811 0.00913553313335151
TF TF:M00122_1 Factor: USF; motif: NNRNCACGTGNYNN; match class: 1 0.0174804552551014 2413 4 4 1 0.00165768752590137
TF TF:M07380 Factor: E2F-4; motif: NTTTCSCGCC 0.0174804552551014 13022 128 103 0.8046875 0.00790969129166027
TF TF:M07063 Factor: Sp1; motif: GGGGCGGGGC 0.0174804552551014 7696 88 51 0.579545454545455 0.00662681912681913
TF TF:M00932 Factor: Sp1; motif: NNGGGGCGGGGNN 0.0174804552551014 10419 88 63 0.715909090909091 0.00604664555139649
TF TF:M00245 Factor: Egr-3; motif: NTGCGTGGGCGK 0.0174804552551014 7313 64 38 0.59375 0.00519622589908382
TF TF:M12152 Factor: Sp1; motif: NWRGCCACGCCCMCN 0.0177604269969063 7341 136 71 0.522058823529412 0.00967170685192753
TF TF:M03920_1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 0.0190240893191346 3020 127 35 0.275590551181102 0.0115894039735099
TF TF:M08451 Factor: Elk-1:HOXA1; motif: ACCGGAAGTAATTA 0.0190240893191346 8421 133 77 0.578947368421053 0.00914380714879468
TF TF:M09833_1 Factor: RXRALPHA; motif: CNNTGRCCTYTNN; match class: 1 0.0190240893191346 987 27 7 0.259259259259259 0.00709219858156028
TF TF:M07084 Factor: E2F-4; motif: NGGCGGGAARN 0.0190240893191346 10834 125 88 0.704 0.00812257707218017
TF TF:M09896 Factor: E2F-7; motif: GRGGCGGGAANNN 0.0190240893191346 9927 131 86 0.656488549618321 0.00866324166414828
TF TF:M11603 Factor: TCF-1; motif: ACATCGRGRCGCTGW 0.0190240893191346 16361 136 127 0.933823529411765 0.00776236171383167
TF TF:M00172 Factor: AP-1; motif: RSTGACTNMNW 0.0190456983654012 2280 21 9 0.428571428571429 0.00394736842105263
TF TF:M02036 Factor: WT1; motif: CGCCCCCNCN 0.0192049986943765 9767 126 82 0.650793650793651 0.0083956178970001
TF TF:M00144 Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM 0.0198173736576077 13205 99 82 0.828282828282828 0.00620976902688376
TF TF:M07226 Factor: SP1; motif: NCCCCKCCCCC 0.0199216715678669 8292 97 58 0.597938144329897 0.00699469368065605
TF TF:M02066 Factor: PEA3; motif: RCCGGAAGYN 0.0200402468776626 7045 135 68 0.503703703703704 0.00965223562810504
TF TF:M11061_1 Factor: HES-1; motif: GGCRCGTGNC; match class: 1 0.0200402468776626 2453 115 28 0.243478260869565 0.0114145943742356
TF TF:M11059 Factor: Hey1; motif: NGCACGTGYN 0.0200402468776626 1813 5 4 0.8 0.00220628792057364
TF TF:M11400 Factor: Fli-1; motif: NACCGGAARTN 0.0200402468776626 9946 133 87 0.654135338345865 0.00874723506937462
TF TF:M06363 Factor: ZNF730; motif: NNGGTGGACCGC 0.0200402468776626 60 108 4 0.037037037037037 0.0666666666666667
TF TF:M09895 Factor: E2F-6; motif: NGGGCGGGARRNN 0.0202661886413029 7765 124 68 0.548387096774194 0.00875724404378622
TF TF:M08759 Factor: c-Ets-2; motif: NCCGGAAGTG 0.0204758719471116 8319 135 77 0.57037037037037 0.00925592018271427
TF TF:M11452_1 Factor: Elf-1; motif: NANGCGGAAGTR; match class: 1 0.0204758719471116 1696 132 24 0.181818181818182 0.0141509433962264
TF TF:M02052_1 Factor: EHF; motif: CSCGGAARTN; match class: 1 0.0205989328852578 4056 135 45 0.333333333333333 0.011094674556213
TF TF:M01298 Factor: MECP2; motif: CCGGSNNNANNAWWT 0.0208494227390396 1290 22 7 0.318181818181818 0.00542635658914729
TF TF:M11531_1 Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 0.0213167996913794 12351 89 71 0.797752808988764 0.00574852238685127
TF TF:M07347 Factor: AhR; motif: NNNKNGCGTGNSNNNNN 0.0215112717299084 1426 3 3 1 0.00210378681626928
TF TF:M11450 Factor: Elf-1; motif: NANSCGGAAGTR 0.0216951346276737 5601 135 57 0.422222222222222 0.0101767541510445
TF TF:M03567 Factor: Sp2; motif: NYSGCCCCGCCCCCY 0.0216951346276737 7710 87 50 0.574712643678161 0.00648508430609598
TF TF:M04624 Factor: Pax-4; motif: DTTTTCCACCN 0.0217490457888342 15765 35 35 1 0.00222010783380907
TF TF:M11424_1 Factor: Erm; motif: NNSCGGAWGYN; match class: 1 0.022028237690065 2835 132 34 0.257575757575758 0.0119929453262787
TF TF:M11452 Factor: Elf-1; motif: NANGCGGAAGTR 0.0222068360072831 6276 135 62 0.459259259259259 0.00987890376035692
TF TF:M12173 Factor: GKLF; motif: NNCCMCRCCCN 0.0222068360072831 10023 131 86 0.656488549618321 0.00858026538960391
TF TF:M11382 Factor: ESE-1; motif: NWTRCGGAWGCN 0.0222068360072831 10339 136 91 0.669117647058823 0.00880162491536899
TF TF:M02089 Factor: E2F-3; motif: GGCGGGN 0.0224287744084328 13173 128 103 0.8046875 0.00781902376072269
TF TF:M10755 Factor: hoxd1; motif: NTCRTTAN 0.0224287744084328 2948 113 31 0.274336283185841 0.0105156037991859
TF TF:M04714 Factor: Elf-1; motif: ACTTCCGGG 0.0224287744084328 7798 135 73 0.540740740740741 0.00936137471146448
TF TF:M00360_1 Factor: Pax-3; motif: TCGTCACRCTTHM; match class: 1 0.0224287744084328 5491 135 56 0.414814814814815 0.0101985066472409
TF TF:M07371 Factor: ZEB; motif: NNNCAGGTGNSN 0.0233297137926967 644 12 4 0.333333333333333 0.0062111801242236
TF TF:M07409 Factor: BTEB2; motif: GCCCCRCCCH 0.0237549649420838 5198 127 51 0.401574803149606 0.00981146594844171
TF TF:M03977 Factor: ETS1; motif: ACCGGAARYN 0.024228606242491 10512 118 81 0.686440677966102 0.00770547945205479
TF TF:M11392 Factor: Erg; motif: NACCGGAARYN 0.0243349272002218 8690 133 78 0.586466165413534 0.00897583429228999
TF TF:M10072 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR 0.0248316470093243 10494 97 68 0.701030927835051 0.0064798932723461
TF TF:M00736 Factor: E2F-1:DP-1; motif: TTTCSCGC 0.0253174035480057 10390 121 82 0.677685950413223 0.00789220404234841
TF TF:M01240_1 Factor: BEN; motif: CAGCGRNV; match class: 1 0.0253174035480057 13227 97 80 0.824742268041237 0.00604823467150525
TF TF:M09606 Factor: nerf; motif: NRRNSCGGAAGNRNNNN 0.0255970136926639 6249 134 61 0.455223880597015 0.00976156184989598
TF TF:M02069 Factor: Erm; motif: ACCGGAAGTN 0.0255970136926639 6892 118 59 0.5 0.00856065002901915
TF TF:M08266_1 Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 0.0266575826869457 8979 124 75 0.604838709677419 0.00835282325425994
TF TF:M11828 Factor: LRH-1; motif: TCAAGGTCRYGACCTTGR 0.0281388561290779 10627 12 12 1 0.00112919920956055
TF TF:M07039 Factor: ETF; motif: CCCCGCCCCYN 0.0281388561290779 16384 40 40 1 0.00244140625
TF TF:M09950 Factor: HSF1; motif: NRGAANNTTCYRGAA 0.0284244979419433 2501 48 15 0.3125 0.00599760095961615
TF TF:M05386 Factor: KLF17; motif: NGGGCGG 0.0293371841391974 7900 97 55 0.56701030927835 0.0069620253164557
TF TF:M05499 Factor: LKLF; motif: NGGGCGG 0.0293371841391974 7900 97 55 0.56701030927835 0.0069620253164557
TF TF:M04698 Factor: GABP-alpha; motif: CACTTCCGG 0.0293371841391974 3196 135 37 0.274074074074074 0.0115769712140175
TF TF:M09990 Factor: c-Myb; motif: NNWGRCAGTTRN 0.0293371841391974 10698 12 12 1 0.00112170499158721
TF TF:M11448_1 Factor: Elf-1; motif: NANGCGGAAGTN; match class: 1 0.0293371841391974 2324 132 29 0.21969696969697 0.0124784853700516
TF TF:M07299 Factor: c-Myb; motif: NNNNCMGTTNNN 0.0293371841391974 3767 10 7 0.7 0.00185824263339527
TF TF:M09739_1 Factor: ZGPAT; motif: GRGGCWGNGGNG; match class: 1 0.0293371841391974 2740 40 14 0.35 0.00510948905109489
TF TF:M11533_1 Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 0.0301471745917573 8705 128 75 0.5859375 0.00861573808156232
TF TF:M10758 Factor: HOXB1; motif: NTCRTTAN 0.0302466441036079 2781 112 29 0.258928571428571 0.0104279036317871
TF TF:M00236 Factor: Arnt; motif: NDDNNCACGTGNNNNN 0.0308250029623695 2210 5 4 0.8 0.00180995475113122
TF TF:M03852 Factor: SREBP-2; motif: NTCACCYNNNN 0.0333956139166644 8142 42 28 0.666666666666667 0.00343895848685827
TF TF:M00123 Factor: c-Myc:Max; motif: NANCACGTGNNW 0.033668848767154 3337 4 4 1 0.00119868145040456
TF TF:M11710_1 Factor: PREP-2; motif: TGACAGCTGTCA; match class: 1 0.033668848767154 37 98 3 0.0306122448979592 0.0810810810810811
TF TF:M11710 Factor: PREP-2; motif: TGACAGCTGTCA 0.033668848767154 37 98 3 0.0306122448979592 0.0810810810810811
TF TF:M11073 Factor: DEC1; motif: GTCACGTGAC 0.033668848767154 6583 117 56 0.478632478632479 0.00850675983594106
TF TF:M04617 Factor: LRF; motif: NGNAGNGGGTYN 0.033668848767154 6164 65 33 0.507692307692308 0.00535366645035691
TF TF:M12186 Factor: BTEB4; motif: NCCACGCCCM 0.033668848767154 9135 127 77 0.606299212598425 0.00842911877394636
TF TF:M11396 Factor: Erg; motif: NACCGGAARTN 0.0351837504092638 10765 135 92 0.681481481481481 0.00854621458430098
TF TF:M04743 Factor: c-Myc; motif: NSCACGTGGN 0.0351837504092638 4819 5 5 1 0.00103755965968043
TF TF:M09636 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG 0.0351837504092638 16244 97 91 0.938144329896907 0.00560206845604531
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.0351837504092638 7728 87 49 0.563218390804598 0.00634057971014493
TF TF:M09894 Factor: E2F-4; motif: SNGGGCGGGAANN 0.0362990118170853 16194 136 125 0.919117647058823 0.00771890823761887
TF TF:M01145_1 Factor: c-Myc; motif: RACCACGTGCTC; match class: 1 0.0369752282285307 3448 4 4 1 0.00116009280742459
TF TF:M11447 Factor: Elf-1; motif: NAMCCGGAAGTN 0.0370630157395663 7703 135 71 0.525925925925926 0.00921718810852915
TF TF:M09876 Factor: DEC1; motif: NGCACGTGAS 0.0370630157395663 8725 23 18 0.782608695652174 0.00206303724928367
TF TF:M11427_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.0371634047557239 4606 132 47 0.356060606060606 0.0102040816326531
TF TF:M01243 Factor: MTF-1; motif: TGCGCAC 0.0371634047557239 2835 13 7 0.538461538461538 0.00246913580246914
TF TF:M09966_1 Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 0.0371634047557239 449 69 7 0.101449275362319 0.0155902004454343
TF TF:M11221 Factor: CREB1; motif: RTGACGYGTCAN 0.0371634047557239 9677 116 74 0.637931034482759 0.00764699803658159
TF TF:M11434_1 Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 0.0380967285302612 2935 99 27 0.272727272727273 0.00919931856899489
TF TF:M11451 Factor: Elf-1; motif: NANCCGGAAGTN 0.0380967285302612 6886 135 65 0.481481481481481 0.00943944234679059
TF TF:M09591 Factor: AP-2gamma; motif: NTGSCCTGRGGSNN 0.0380967285302612 8337 38 26 0.684210526315789 0.00311862780376634
TF TF:M11427 Factor: PEA3; motif: NACCGGAAGTN 0.0385995422086372 10585 116 79 0.681034482758621 0.0074633915918753
TF TF:M00799 Factor: Myc; motif: CACGTGS 0.0385995422086372 4988 5 5 1 0.00100240577385726
TF TF:M10999 Factor: LIM-1; motif: NNCGTTAN 0.0385995422086372 5894 114 50 0.43859649122807 0.00848320325755005
TF TF:M00144_1 Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM; match class: 1 0.0385995422086372 7128 131 65 0.49618320610687 0.00911896745230079
TF TF:M09963 Factor: JunB; motif: NNTGAGTCANN 0.0385995422086372 905 18 5 0.277777777777778 0.00552486187845304
TF TF:M09723 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS 0.0385995422086372 10156 127 83 0.653543307086614 0.0081725088617566
TF TF:M02063 Factor: c-ets-1; motif: ACCGGAWGTN 0.0393510289098558 7600 135 70 0.518518518518518 0.00921052631578947
TF TF:M08207_1 Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 0.0394679429308173 15466 97 88 0.907216494845361 0.00568990042674253
TF TF:M09892_1 Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 0.0394679429308173 9162 109 67 0.614678899082569 0.00731281379611439
TF TF:M12342_1 Factor: BCL-6; motif: NNGYAATCGAGGAATN; match class: 1 0.0394679429308173 570 28 5 0.178571428571429 0.0087719298245614
TF TF:M08913 Factor: FLI-1; motif: NAYTTCCGGT 0.0396062225914799 8322 135 75 0.555555555555556 0.00901225666906993
TF TF:M11074_1 Factor: DEC1; motif: GTCACGTGAC; match class: 1 0.0396062225914799 3890 8 6 0.75 0.00154241645244216
TF TF:M12351 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC 0.0396062225914799 12302 136 102 0.75 0.00829133474231832
TF TF:M10747 Factor: GSH2; motif: NTCRTTAN 0.0396062225914799 3019 112 30 0.267857142857143 0.00993706525339516
TF TF:M12057 Factor: ZBP99; motif: GCCCMTCCCCCR 0.0396062225914799 5225 32 17 0.53125 0.00325358851674641
TF TF:M10942 Factor: VSX1; motif: NTCRTTAN 0.0396062225914799 3019 112 30 0.267857142857143 0.00993706525339516
TF TF:M10945 Factor: VSX1; motif: NTCRTTAN 0.0396062225914799 3019 112 30 0.267857142857143 0.00993706525339516
TF TF:M08868 Factor: ARNTLIKE; motif: NNNSCACGTG 0.0396062225914799 5094 5 5 1 0.000981546917942678
TF TF:M04710 Factor: CHD2; motif: TCTCGCGAG 0.0396062225914799 14109 136 113 0.830882352941177 0.0080090722234035
TF TF:M08523_1 Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN; match class: 1 0.0396062225914799 7423 65 37 0.569230769230769 0.00498450761147784
TF TF:M10563 Factor: Msx-1; motif: NTCRTTAN 0.0396062225914799 3019 112 30 0.267857142857143 0.00993706525339516
TF TF:M10939 Factor: CHX10; motif: NTCRTTAN 0.0396062225914799 3019 112 30 0.267857142857143 0.00993706525339516
TF TF:M02071 Factor: ETV7; motif: NCCGGAANNN 0.0396062225914799 10116 133 86 0.646616541353383 0.0085013839462238
TF TF:M04811_1 Factor: RelA-p65; motif: BCWGGGRANNK; match class: 1 0.0396062225914799 1834 10 5 0.5 0.00272628135223555
TF TF:M10936 Factor: CHX10; motif: NTCRTTAN 0.0396062225914799 3019 112 30 0.267857142857143 0.00993706525339516
TF TF:M10874 Factor: alx3; motif: NKCRTTAN 0.0396062225914799 3019 112 30 0.267857142857143 0.00993706525339516
TF TF:M07394 Factor: slug; motif: CACCTGNNN 0.0397357113637016 1746 124 22 0.17741935483871 0.0126002290950745
TF TF:M08457 Factor: ER71:SREBP-2; motif: NTSACGTGACGGAARY 0.0398995319776334 12052 109 82 0.752293577981651 0.00680384998340524
TF TF:M01489_1 Factor: NKX6A; motif: NNNAATTAATTAMYNNG; match class: 1 0.0398995319776334 212 44 4 0.0909090909090909 0.0188679245283019
TF TF:M00470 Factor: AP-2gamma; motif: GCCYNNGGS 0.0398995319776334 9422 9 9 1 0.000955211207811505
TF TF:M09726_1 Factor: GATAD2A; motif: CCTKTG; match class: 1 0.0398995319776334 9052 12 11 0.916666666666667 0.00121520106053911
TF TF:M11601 Factor: TCF-1; motif: ACATCGRGRCGCTGW 0.0398995319776334 14823 131 113 0.862595419847328 0.00762328813330635
TF TF:M07277 Factor: BTEB2; motif: RGGGNGKGGN 0.0398995319776334 8492 127 72 0.566929133858268 0.00847856806406029
TF TF:M09969 Factor: EKLF; motif: NGGGYGKGGCNNGG 0.0398995319776334 4589 127 45 0.354330708661417 0.00980605796469819
TF TF:M00187_1 Factor: USF; motif: GYCACGTGNC; match class: 1 0.0398995319776334 1528 115 19 0.165217391304348 0.012434554973822
TF TF:M09812_1 Factor: MYC; motif: NNCCACGTGCNN; match class: 1 0.0398995319776334 5242 5 5 1 0.00095383441434567
TF TF:M01154_1 Factor: c-Myc; motif: KACCACGTGSYY; match class: 1 0.0398995319776334 3751 4 4 1 0.00106638229805385
TF TF:M08568_1 Factor: ER71:E2A; motif: CASSTGNACCGGAWRYN; match class: 1 0.0398995319776334 15133 135 118 0.874074074074074 0.00779752857992467
TF TF:M08207 Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT 0.0398995319776334 17055 136 129 0.948529411764706 0.00756376429199648
TF TF:M08525 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM 0.0398995319776334 17065 136 129 0.948529411764706 0.00755933196601231
TF TF:M09918_1 Factor: Pet-1; motif: GCNGGAAGYG; match class: 1 0.0398995319776334 7159 33 21 0.636363636363636 0.00293337058248359
TF TF:M01273 Factor: SP4; motif: SCCCCGCCCCS 0.0400287171273568 3296 86 26 0.302325581395349 0.00788834951456311
TF TF:M10071_1 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 0.0405096569036225 4623 86 33 0.383720930232558 0.00713822193380921
TF TF:M01154 Factor: c-Myc; motif: KACCACGTGSYY 0.041674266594587 5313 5 5 1 0.000941087897609637
TF TF:M10109 Factor: ZNF324; motif: KNTCAAACCATCCTTNNCTKSCN 0.041674266594587 2216 3 3 1 0.00135379061371841
TF TF:M00803_1 Factor: E2F; motif: GGCGSG; match class: 1 0.041674266594587 10230 127 83 0.653543307086614 0.00811339198435973
TF TF:M11703 Factor: Meis-2; motif: TGACASCTGTCA 0.0422983760788309 45 98 3 0.0306122448979592 0.0666666666666667
TF TF:M11703_1 Factor: Meis-2; motif: TGACASCTGTCA; match class: 1 0.0422983760788309 45 98 3 0.0306122448979592 0.0666666666666667
TF TF:M02053 Factor: ELF1; motif: NCCGGAARTN 0.0425222720715478 6033 113 50 0.442477876106195 0.00828775070445881
TF TF:M00539 Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN 0.0425545535947565 6676 6 6 1 0.000898741761533853
TF TF:M00539_1 Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN; match class: 1 0.0425545535947565 6676 6 6 1 0.000898741761533853
TF TF:M09905 Factor: SAP-1; motif: NNCCGGAAGTGN 0.0425545535947565 8273 118 66 0.559322033898305 0.00797775897497885
TF TF:M02070_1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 0.0425545535947565 4841 135 49 0.362962962962963 0.0101218756455278
TF TF:M04726 Factor: REST; motif: GGACAGCKC 0.0425545535947565 5878 10 8 0.8 0.00136100714528751
TF TF:M11074 Factor: DEC1; motif: GTCACGTGAC 0.0444059788435952 4132 8 6 0.75 0.00145208131655373
TF TF:M02055 Factor: ESE-1; motif: NSMGGAARTN 0.0453918165011207 7559 135 69 0.511111111111111 0.00912819155973012
TF TF:M01214 Factor: ESE-1; motif: NSMGGAARTN 0.0453918165011207 7559 135 69 0.511111111111111 0.00912819155973012
TF TF:M11385_1 Factor: ESE-1; motif: NTGTGCGGATGCN; match class: 1 0.0458243744415289 5491 5 5 1 0.000910580950646512
TF TF:M10056 Factor: DRRS; motif: GNNGGGWGGG 0.0460546788474656 4799 62 26 0.419354838709677 0.00541779537403626
TF TF:M09918 Factor: Pet-1; motif: GCNGGAAGYG 0.0460966969600875 13610 110 90 0.818181818181818 0.00661278471711976
TF TF:M09812 Factor: MYC; motif: NNCCACGTGCNN 0.0460966969600875 5507 5 5 1 0.000907935355002724
TF TF:M08443 Factor: AP-4:ER81; motif: RSCGGAAGCAGSTGNN 0.0461021418796461 10698 63 46 0.73015873015873 0.00429986913441765
TF TF:M03988 Factor: FLI1; motif: ACCGGAARTN 0.0461021418796461 8318 120 67 0.558333333333333 0.00805482087040154
TF TF:M00739 Factor: E2F-4:DP-2; motif: TTTCSCGC 0.0461021418796461 5624 127 52 0.409448818897638 0.00924608819345661
TF TF:M02052 Factor: EHF; motif: CSCGGAARTN 0.0477995583376232 10107 136 87 0.639705882352941 0.00860789551795785
TF TF:M02065_1 Factor: ER81; motif: RCCGGAARYN; match class: 1 0.0477995583376232 6749 135 63 0.466666666666667 0.00933471625425989
TF TF:M08441 Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG 0.0483778104615463 16345 128 118 0.921875 0.00721933312939737
TF TF:M11528 Factor: E2F-2; motif: NTTTTGGCGCCAWWWN 0.0484529753229195 10373 96 65 0.677083333333333 0.0062662681962788
TF TF:M09876_1 Factor: DEC1; motif: NGCACGTGAS; match class: 1 0.0484529753229195 6252 8 7 0.875 0.00111964171465131
TF TF:M07405_1 Factor: SREBP-1; motif: RTCACCCCAY; match class: 1 0.0491995640157577 1516 8 4 0.5 0.00263852242744063
TF TF:M01252_1 Factor: E2F-6; motif: CNTTTCNT; match class: 1 0.0492093613216114 222 47 4 0.0851063829787234 0.018018018018018
TF TF:M03922 Factor: SP4; motif: NWRGCCACGCCCMCTYN 0.0492093613216114 6046 133 57 0.428571428571429 0.00942772080714522
TF TF:M08445_1 Factor: AP-4:Fli-1; motif: RSCGGAWRCAGSTGN; match class: 1 0.0493780601539585 3143 35 13 0.371428571428571 0.00413617562838053
TF TF:M08529_1 Factor: E2F-3:T-bet; motif: AGGTGTNANGGCGCST; match class: 1 0.0499809290653456 4794 88 34 0.386363636363636 0.00709219858156028

pEpiTp23 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp23
Possible regulators of activation of pEpiTp23 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.