pEpiTp21 program activity among Epithelial cells

Activation of pEpiTp21
pEpiTp21 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp21 by different cell subtypes
pEpiTp21 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp21 top program genes

Top genes of pEpiTp21 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp21 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp21
pEpiTp21 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:7385 DTX3L-PARP9-STAT1 complex 0.000321533946831896 3 54 3 0.0555555555555556 1
CORUM CORUM:60 Interferon-stimulated gene factor 3 transcription complex ISGF3 0.0015175510436912 3 113 3 0.0265486725663717 1
GO:BP GO:0071357 cellular response to type I interferon 7.69288128940164e-39 96 113 29 0.256637168141593 0.302083333333333
GO:BP GO:0060337 type I interferon signaling pathway 7.69288128940164e-39 95 113 29 0.256637168141593 0.305263157894737
GO:BP GO:0034340 response to type I interferon 2.83858824111149e-38 101 113 29 0.256637168141593 0.287128712871287
GO:BP GO:0140546 defense response to symbiont 6.58748103506357e-37 267 73 32 0.438356164383562 0.119850187265918
GO:BP GO:0051607 defense response to virus 6.58748103506357e-37 267 73 32 0.438356164383562 0.119850187265918
GO:BP GO:0009615 response to virus 7.78589732532681e-36 364 73 34 0.465753424657534 0.0934065934065934
GO:BP GO:0045087 innate immune response 2.04094658434686e-27 998 73 39 0.534246575342466 0.0390781563126252
GO:BP GO:0098542 defense response to other organism 1.8717661455228e-25 1218 73 40 0.547945205479452 0.0328407224958949
GO:BP GO:0048525 negative regulation of viral process 4.84522747929964e-25 94 61 18 0.295081967213115 0.191489361702128
GO:BP GO:0019221 cytokine-mediated signaling pathway 2.6622219078036e-24 810 113 41 0.36283185840708 0.0506172839506173
GO:BP GO:0043207 response to external biotic stimulus 1.66038166384364e-23 1594 73 42 0.575342465753425 0.0263488080301129
GO:BP GO:0009607 response to biotic stimulus 1.66038166384364e-23 1626 118 54 0.457627118644068 0.033210332103321
GO:BP GO:0051707 response to other organism 1.66038166384364e-23 1592 73 42 0.575342465753425 0.0263819095477387
GO:BP GO:0034097 response to cytokine 1.96718555524163e-23 1226 113 47 0.415929203539823 0.0383360522022839
GO:BP GO:0045071 negative regulation of viral genome replication 1.96718555524163e-23 54 61 15 0.245901639344262 0.277777777777778
GO:BP GO:0045069 regulation of viral genome replication 3.23645875130025e-22 84 61 16 0.262295081967213 0.19047619047619
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 1.54533395816881e-21 2255 74 46 0.621621621621622 0.0203991130820399
GO:BP GO:0050792 regulation of viral process 1.80615062868169e-21 192 141 25 0.177304964539007 0.130208333333333
GO:BP GO:1903900 regulation of viral life cycle 3.98351992533915e-21 153 141 23 0.163120567375887 0.150326797385621
GO:BP GO:0071345 cellular response to cytokine stimulus 5.09567699902495e-21 1132 113 43 0.380530973451327 0.0379858657243816
GO:BP GO:0043903 regulation of biological process involved in symbiotic interaction 6.38320877075805e-21 203 141 25 0.177304964539007 0.123152709359606
GO:BP GO:0019079 viral genome replication 7.73778907583653e-21 131 61 17 0.278688524590164 0.129770992366412
GO:BP GO:0006952 defense response 2.01007749598166e-20 1818 73 41 0.561643835616438 0.0225522552255226
GO:BP GO:0002252 immune effector process 4.17337213283944e-20 1309 73 36 0.493150684931507 0.027501909854851
GO:BP GO:0006955 immune response 1.64893705462656e-18 2311 73 43 0.589041095890411 0.0186066637819126
GO:BP GO:0016032 viral process 4.65282513429171e-18 942 141 41 0.290780141843972 0.0435244161358811
GO:BP GO:0044403 biological process involved in symbiotic interaction 4.07725988929926e-17 1001 141 41 0.290780141843972 0.040959040959041
GO:BP GO:0009605 response to external stimulus 8.77606259616568e-16 2944 123 61 0.495934959349593 0.0207201086956522
GO:BP GO:0019058 viral life cycle 3.59642531170697e-15 353 141 25 0.177304964539007 0.0708215297450425
GO:BP GO:0035455 response to interferon-alpha 4.34287675241285e-15 23 65 9 0.138461538461538 0.391304347826087
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 2.49367359697216e-14 88 113 14 0.123893805309735 0.159090909090909
GO:BP GO:0071310 cellular response to organic substance 3.72422575370393e-14 2776 87 46 0.528735632183908 0.0165706051873199
GO:BP GO:0002376 immune system process 3.90740295798189e-14 3278 88 50 0.568181818181818 0.0152532031726663
GO:BP GO:0034341 response to interferon-gamma 7.16340334339537e-14 196 70 15 0.214285714285714 0.076530612244898
GO:BP GO:0002831 regulation of response to biotic stimulus 1.5827543637803e-12 415 92 20 0.217391304347826 0.0481927710843374
GO:BP GO:0010033 response to organic substance 3.26076027013759e-12 3412 87 48 0.551724137931034 0.0140679953106682
GO:BP GO:0006950 response to stress 2.81937250060174e-11 4170 93 54 0.580645161290323 0.0129496402877698
GO:BP GO:0070887 cellular response to chemical stimulus 6.70008938280252e-11 3393 87 46 0.528735632183908 0.0135573239021515
GO:BP GO:0035456 response to interferon-beta 6.93380438097436e-11 30 85 8 0.0941176470588235 0.266666666666667
GO:BP GO:0071346 cellular response to interferon-gamma 2.21363203635606e-10 175 70 12 0.171428571428571 0.0685714285714286
GO:BP GO:0007166 cell surface receptor signaling pathway 2.45786579674312e-10 3210 113 52 0.460176991150442 0.0161993769470405
GO:BP GO:0045088 regulation of innate immune response 2.2541764594081e-09 309 62 13 0.209677419354839 0.0420711974110032
GO:BP GO:0032479 regulation of type I interferon production 2.25684506710626e-08 130 108 11 0.101851851851852 0.0846153846153846
GO:BP GO:0032606 type I interferon production 2.39588390932201e-08 131 108 11 0.101851851851852 0.083969465648855
GO:BP GO:0042221 response to chemical 1.01686697660584e-07 4781 93 52 0.559139784946237 0.0108763856933696
GO:BP GO:0031347 regulation of defense response 1.30469307218574e-07 704 73 17 0.232876712328767 0.0241477272727273
GO:BP GO:0007165 signal transduction 3.24451356946886e-07 6309 120 73 0.608333333333333 0.01157077191314
GO:BP GO:0060700 regulation of ribonuclease activity 3.38057180449831e-07 9 48 4 0.0833333333333333 0.444444444444444
GO:BP GO:0032101 regulation of response to external stimulus 3.61670814543089e-07 1051 75 20 0.266666666666667 0.0190294957183635
GO:BP GO:0002682 regulation of immune system process 4.52827813245221e-07 1617 78 25 0.320512820512821 0.015460729746444
GO:BP GO:0032607 interferon-alpha production 4.52827813245221e-07 30 92 6 0.0652173913043478 0.2
GO:BP GO:0032647 regulation of interferon-alpha production 4.52827813245221e-07 30 92 6 0.0652173913043478 0.2
GO:BP GO:0048519 negative regulation of biological process 7.72095149477246e-07 5757 82 51 0.621951219512195 0.0088587806149036
GO:BP GO:0140289 protein mono-ADP-ribosylation 1.15992543594573e-06 12 142 5 0.0352112676056338 0.416666666666667
GO:BP GO:0060759 regulation of response to cytokine stimulus 1.53264023961784e-06 197 85 10 0.117647058823529 0.050761421319797
GO:BP GO:0032480 negative regulation of type I interferon production 1.53264023961784e-06 46 73 6 0.0821917808219178 0.130434782608696
GO:BP GO:0002833 positive regulation of response to biotic stimulus 2.92899857446011e-06 250 92 11 0.119565217391304 0.044
GO:BP GO:0098586 cellular response to virus 4.02290183391588e-06 72 92 7 0.0760869565217391 0.0972222222222222
GO:BP GO:0045824 negative regulation of innate immune response 4.9342803982716e-06 66 62 6 0.0967741935483871 0.0909090909090909
GO:BP GO:0032727 positive regulation of interferon-alpha production 5.95568528532154e-06 24 92 5 0.0543478260869565 0.208333333333333
GO:BP GO:0023052 signaling 9.43903435735907e-06 6810 120 73 0.608333333333333 0.01071953010279
GO:BP GO:0007154 cell communication 1.05535375966257e-05 6829 120 73 0.608333333333333 0.0106897056670083
GO:BP GO:0060760 positive regulation of response to cytokine stimulus 1.27205689718324e-05 57 85 6 0.0705882352941176 0.105263157894737
GO:BP GO:0032069 regulation of nuclease activity 1.43521501653449e-05 22 48 4 0.0833333333333333 0.181818181818182
GO:BP GO:0006471 protein ADP-ribosylation 1.54409754997297e-05 36 142 6 0.0422535211267606 0.166666666666667
GO:BP GO:0050896 response to stimulus 1.58336594236479e-05 9407 32 30 0.9375 0.00318911448921016
GO:BP GO:0050688 regulation of defense response to virus 1.80931478409654e-05 71 73 6 0.0821917808219178 0.0845070422535211
GO:BP GO:0032481 positive regulation of type I interferon production 2.15378511112211e-05 80 108 7 0.0648148148148148 0.0875
GO:BP GO:0001817 regulation of cytokine production 2.35793291467431e-05 806 92 17 0.184782608695652 0.0210918114143921
GO:BP GO:0060338 regulation of type I interferon-mediated signaling pathway 2.51275147654521e-05 35 85 5 0.0588235294117647 0.142857142857143
GO:BP GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 2.71085388224481e-05 33 92 5 0.0543478260869565 0.151515151515152
GO:BP GO:0080134 regulation of response to stress 2.75101974481205e-05 1443 73 20 0.273972602739726 0.0138600138600139
GO:BP GO:0045089 positive regulation of innate immune response 2.85694439600507e-05 216 43 7 0.162790697674419 0.0324074074074074
GO:BP GO:1903901 negative regulation of viral life cycle 3.7194960805996e-05 26 53 4 0.0754716981132075 0.153846153846154
GO:BP GO:0050776 regulation of immune response 3.7194960805996e-05 996 70 16 0.228571428571429 0.0160642570281124
GO:BP GO:0001816 cytokine production 4.04867522260801e-05 844 92 17 0.184782608695652 0.0201421800947867
GO:BP GO:0002832 negative regulation of response to biotic stimulus 4.53265325885002e-05 100 62 6 0.0967741935483871 0.06
GO:BP GO:0032020 ISG15-protein conjugation 4.78473128492919e-05 6 73 3 0.0410958904109589 0.5
GO:BP GO:0039530 MDA-5 signaling pathway 5.21824887291968e-05 10 42 3 0.0714285714285714 0.3
GO:BP GO:0032103 positive regulation of response to external stimulus 7.02183454660038e-05 513 92 13 0.141304347826087 0.0253411306042885
GO:BP GO:0001959 regulation of cytokine-mediated signaling pathway 8.04258132040253e-05 184 59 7 0.11864406779661 0.0380434782608696
GO:BP GO:0060330 regulation of response to interferon-gamma 0.000106342725001602 26 20 3 0.15 0.115384615384615
GO:BP GO:0060334 regulation of interferon-gamma-mediated signaling pathway 0.000106342725001602 26 20 3 0.15 0.115384615384615
GO:BP GO:0051716 cellular response to stimulus 0.000177140452990087 7781 46 35 0.760869565217391 0.00449813648631281
GO:BP GO:0002221 pattern recognition receptor signaling pathway 0.000182859217735555 213 108 9 0.0833333333333333 0.0422535211267606
GO:BP GO:0032648 regulation of interferon-beta production 0.000227138709235341 52 92 5 0.0543478260869565 0.0961538461538462
GO:BP GO:0002230 positive regulation of defense response to virus by host 0.000235840098475308 33 68 4 0.0588235294117647 0.121212121212121
GO:BP GO:0032608 interferon-beta production 0.000267958211812353 54 92 5 0.0543478260869565 0.0925925925925926
GO:BP GO:0051701 biological process involved in interaction with host 0.000307961341998868 221 141 10 0.0709219858156028 0.0452488687782805
GO:BP GO:0035457 cellular response to interferon-alpha 0.000409440088876669 13 65 3 0.0461538461538462 0.230769230769231
GO:BP GO:0010629 negative regulation of gene expression 0.000442013573849692 1460 108 23 0.212962962962963 0.0157534246575342
GO:BP GO:0000209 protein polyubiquitination 0.000492927780744984 342 141 12 0.0851063829787234 0.0350877192982456
GO:BP GO:0002697 regulation of immune effector process 0.000492927780744984 461 73 10 0.136986301369863 0.0216919739696312
GO:BP GO:0050777 negative regulation of immune response 0.000500361273571301 157 62 6 0.0967741935483871 0.0382165605095541
GO:BP GO:0046596 regulation of viral entry into host cell 0.000623864023600943 43 141 5 0.0354609929078014 0.116279069767442
GO:BP GO:0050691 regulation of defense response to virus by host 0.000623864023600943 43 68 4 0.0588235294117647 0.0930232558139535
GO:BP GO:0031349 positive regulation of defense response 0.000636928001464552 362 43 7 0.162790697674419 0.0193370165745856
GO:BP GO:0001961 positive regulation of cytokine-mediated signaling pathway 0.00065422968518497 50 20 3 0.15 0.06
GO:BP GO:0001818 negative regulation of cytokine production 0.00065422968518497 381 73 9 0.123287671232877 0.0236220472440945
GO:BP GO:0062208 positive regulation of pattern recognition receptor signaling pathway 0.000732417012754707 43 147 5 0.0340136054421769 0.116279069767442
GO:BP GO:0046597 negative regulation of viral entry into host cell 0.00076498846898651 20 53 3 0.0566037735849057 0.15
GO:BP GO:0048583 regulation of response to stimulus 0.000801216991051469 4278 93 40 0.43010752688172 0.00935016362786349
GO:BP GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 0.000808433649892171 73 147 6 0.0408163265306122 0.0821917808219178
GO:BP GO:0051336 regulation of hydrolase activity 0.000911826647339573 1321 30 10 0.333333333333333 0.00757002271006813
GO:BP GO:0032728 positive regulation of interferon-beta production 0.00091635158015361 36 92 4 0.0434782608695652 0.111111111111111
GO:BP GO:0052372 modulation by symbiont of entry into host 0.00117146519856225 50 141 5 0.0354609929078014 0.1
GO:BP GO:0009966 regulation of signal transduction 0.00122265755264614 3165 120 39 0.325 0.0123222748815166
GO:BP GO:0071360 cellular response to exogenous dsRNA 0.001256943995018 19 68 3 0.0441176470588235 0.157894736842105
GO:BP GO:0048584 positive regulation of response to stimulus 0.00140122901162884 2344 111 30 0.27027027027027 0.0127986348122867
GO:BP GO:0070213 protein auto-ADP-ribosylation 0.00193913699120251 11 142 3 0.0211267605633803 0.272727272727273
GO:BP GO:0052126 movement in host environment 0.00193913699120251 177 141 8 0.0567375886524823 0.0451977401129944
GO:BP GO:0002683 negative regulation of immune system process 0.00203518003197014 420 78 9 0.115384615384615 0.0214285714285714
GO:BP GO:0035556 intracellular signal transduction 0.00205388344566829 2772 120 35 0.291666666666667 0.0126262626262626
GO:BP GO:0001819 positive regulation of cytokine production 0.00205666460797602 452 108 11 0.101851851851852 0.0243362831858407
GO:BP GO:0071359 cellular response to dsRNA 0.00210364789865108 23 68 3 0.0441176470588235 0.130434782608696
GO:BP GO:0090557 establishment of endothelial intestinal barrier 0.00212948460548051 12 136 3 0.0220588235294118 0.25
GO:BP GO:0030522 intracellular receptor signaling pathway 0.00240128040365568 284 92 8 0.0869565217391304 0.028169014084507
GO:BP GO:0032869 cellular response to insulin stimulus 0.00241053909896239 235 111 8 0.0720720720720721 0.0340425531914894
GO:BP GO:0006508 proteolysis 0.00252310716210626 1836 4 4 1 0.00217864923747277
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.00269403792362749 3241 25 13 0.52 0.00401110768281395
GO:BP GO:0010646 regulation of cell communication 0.00270024188837061 3543 120 41 0.341666666666667 0.0115721140276602
GO:BP GO:0046718 viral entry into host cell 0.00276971577724369 141 141 7 0.049645390070922 0.049645390070922
GO:BP GO:0009892 negative regulation of metabolic process 0.00278861005198048 3479 77 29 0.376623376623377 0.00833572865766025
GO:BP GO:0035458 cellular response to interferon-beta 0.00287693226235532 21 85 3 0.0352941176470588 0.142857142857143
GO:BP GO:0023051 regulation of signaling 0.00324884515786296 3578 120 41 0.341666666666667 0.0114589155953046
GO:BP GO:0065009 regulation of molecular function 0.00324884515786296 3221 32 15 0.46875 0.00465693883886992
GO:BP GO:0006915 apoptotic process 0.00324884515786296 1990 29 11 0.379310344827586 0.00552763819095477
GO:BP GO:0010647 positive regulation of cell communication 0.00356016690319162 1777 111 24 0.216216216216216 0.0135059088351154
GO:BP GO:0023056 positive regulation of signaling 0.00360472151555796 1782 111 24 0.216216216216216 0.0134680134680135
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.00388483472102855 2518 32 13 0.40625 0.00516282764098491
GO:BP GO:0031348 negative regulation of defense response 0.0039881162887884 246 62 6 0.0967741935483871 0.024390243902439
GO:BP GO:0002684 positive regulation of immune system process 0.0039881162887884 1065 70 13 0.185714285714286 0.0122065727699531
GO:BP GO:0030097 hemopoiesis 0.0039881162887884 928 25 7 0.28 0.00754310344827586
GO:BP GO:0070936 protein K48-linked ubiquitination 0.0039881162887884 61 85 4 0.0470588235294118 0.0655737704918033
GO:BP GO:0044409 entry into host 0.0041227656074592 154 141 7 0.049645390070922 0.0454545454545455
GO:BP GO:0050790 regulation of catalytic activity 0.0041227656074592 2545 32 13 0.40625 0.00510805500982318
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.00421977499159372 1082 3 3 1 0.00277264325323475
GO:BP GO:0062207 regulation of pattern recognition receptor signaling pathway 0.00440838234809332 108 92 5 0.0543478260869565 0.0462962962962963
GO:BP GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 0.00444867142483702 66 82 4 0.0487804878048781 0.0606060606060606
GO:BP GO:0032897 negative regulation of viral transcription 0.00467232958981398 16 141 3 0.0212765957446809 0.1875
GO:BP GO:0009967 positive regulation of signal transduction 0.00468750177167129 1598 111 22 0.198198198198198 0.0137672090112641
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.00474873315391155 966 25 7 0.28 0.0072463768115942
GO:BP GO:0051248 negative regulation of protein metabolic process 0.00488633312170475 1151 3 3 1 0.00260642919200695
GO:BP GO:0030099 myeloid cell differentiation 0.00490529674561931 428 25 5 0.2 0.0116822429906542
GO:BP GO:0012501 programmed cell death 0.00526243659308429 2143 29 11 0.379310344827586 0.00513299113392441
GO:BP GO:0002718 regulation of cytokine production involved in immune response 0.00548018179261325 85 68 4 0.0588235294117647 0.0470588235294118
GO:BP GO:0039529 RIG-I signaling pathway 0.00560436002249969 26 92 3 0.0326086956521739 0.115384615384615
GO:BP GO:0061025 membrane fusion 0.00560436002249969 179 33 4 0.121212121212121 0.0223463687150838
GO:BP GO:0051098 regulation of binding 0.00589739997501371 365 65 7 0.107692307692308 0.0191780821917808
GO:BP GO:0002520 immune system development 0.0061539861983408 1020 25 7 0.28 0.00686274509803922
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 0.00627210400030699 291 108 8 0.0740740740740741 0.0274914089347079
GO:BP GO:0007259 receptor signaling pathway via JAK-STAT 0.00680349098892923 174 99 6 0.0606060606060606 0.0344827586206897
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.00697957898060826 2719 32 13 0.40625 0.0047811695476278
GO:BP GO:0046628 positive regulation of insulin receptor signaling pathway 0.00719192750104425 24 111 3 0.027027027027027 0.125
GO:BP GO:0002367 cytokine production involved in immune response 0.00744262716593408 94 68 4 0.0588235294117647 0.0425531914893617
GO:BP GO:0008219 cell death 0.0075326324158973 2292 13 7 0.538461538461538 0.00305410122164049
GO:BP GO:0032868 response to insulin 0.0078522439565137 295 111 8 0.0720720720720721 0.0271186440677966
GO:BP GO:0030218 erythrocyte differentiation 0.0078522439565137 116 24 3 0.125 0.0258620689655172
GO:BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 0.00792824820439703 75 37 3 0.0810810810810811 0.04
GO:BP GO:0010628 positive regulation of gene expression 0.00807020282582572 1160 108 17 0.157407407407407 0.0146551724137931
GO:BP GO:0044092 negative regulation of molecular function 0.00807020282582572 1219 29 8 0.275862068965517 0.00656275635767022
GO:BP GO:0097696 receptor signaling pathway via STAT 0.00840841492711272 184 99 6 0.0606060606060606 0.0326086956521739
GO:BP GO:0034101 erythrocyte homeostasis 0.00911146853322283 124 24 3 0.125 0.0241935483870968
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 0.00912537409418682 80 37 3 0.0810810810810811 0.0375
GO:BP GO:1900078 positive regulation of cellular response to insulin stimulus 0.00923527783662926 27 111 3 0.027027027027027 0.111111111111111
GO:BP GO:0050778 positive regulation of immune response 0.00934575341233701 753 70 10 0.142857142857143 0.0132802124833997
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 0.00956054904186864 185 141 7 0.049645390070922 0.0378378378378378
GO:BP GO:1901223 negative regulation of NIK/NF-kappaB signaling 0.0105588647112515 39 81 3 0.037037037037037 0.0769230769230769
GO:BP GO:0002440 production of molecular mediator of immune response 0.010760190168017 189 68 5 0.0735294117647059 0.0264550264550265
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 0.0113713811137976 251 108 7 0.0648148148148148 0.0278884462151394
GO:BP GO:0046822 regulation of nucleocytoplasmic transport 0.0118080468399692 115 29 3 0.103448275862069 0.0260869565217391
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 0.0120147909106774 901 32 7 0.21875 0.00776914539400666
GO:BP GO:0043086 negative regulation of catalytic activity 0.0124908038839922 851 25 6 0.24 0.00705052878965922
GO:BP GO:0043330 response to exogenous dsRNA 0.0124908038839922 50 68 3 0.0441176470588235 0.06
GO:BP GO:2000736 regulation of stem cell differentiation 0.0137229175629972 115 31 3 0.0967741935483871 0.0260869565217391
GO:BP GO:0002262 myeloid cell homeostasis 0.0140265318891951 151 24 3 0.125 0.0198675496688742
GO:BP GO:0001960 negative regulation of cytokine-mediated signaling pathway 0.0142432809272061 82 44 3 0.0681818181818182 0.0365853658536585
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 0.0146497559489148 99 37 3 0.0810810810810811 0.0303030303030303
GO:BP GO:0099637 neurotransmitter receptor transport 0.0147248896125838 49 75 3 0.04 0.0612244897959184
GO:BP GO:0002720 positive regulation of cytokine production involved in immune response 0.0147248896125838 54 68 3 0.0441176470588235 0.0555555555555556
GO:BP GO:0051051 negative regulation of transport 0.0151166328492972 474 80 8 0.1 0.0168776371308017
GO:BP GO:1902653 secondary alcohol biosynthetic process 0.0151166328492972 74 112 4 0.0357142857142857 0.0540540540540541
GO:BP GO:0006695 cholesterol biosynthetic process 0.0151166328492972 74 112 4 0.0357142857142857 0.0540540540540541
GO:BP GO:0071375 cellular response to peptide hormone stimulus 0.0152018223408906 340 111 8 0.0720720720720721 0.0235294117647059
GO:BP GO:0019222 regulation of metabolic process 0.0154705157760353 7148 113 61 0.539823008849557 0.00853385562395076
GO:BP GO:0043331 response to dsRNA 0.0156511835239887 56 68 3 0.0441176470588235 0.0535714285714286
GO:BP GO:0044265 cellular macromolecule catabolic process 0.0158408680278736 1231 140 20 0.142857142857143 0.016246953696182
GO:BP GO:0060761 negative regulation of response to cytokine stimulus 0.0159141246342038 88 44 3 0.0681818181818182 0.0340909090909091
GO:BP GO:0051224 negative regulation of protein transport 0.017438599059585 135 111 5 0.045045045045045 0.037037037037037
GO:BP GO:0002244 hematopoietic progenitor cell differentiation 0.017560437638361 172 24 3 0.125 0.0174418604651163
GO:BP GO:0016126 sterol biosynthetic process 0.0180815633621957 80 112 4 0.0357142857142857 0.05
GO:BP GO:2000113 negative regulation of cellular macromolecule biosynthetic process 0.0181544527975826 1628 32 9 0.28125 0.00552825552825553
GO:BP GO:0009968 negative regulation of signal transduction 0.0181544527975826 1364 120 19 0.158333333333333 0.0139296187683284
GO:BP GO:0051091 positive regulation of DNA-binding transcription factor activity 0.0182368845902012 270 146 8 0.0547945205479452 0.0296296296296296
GO:BP GO:0016050 vesicle organization 0.0187146197471274 341 91 7 0.0769230769230769 0.0205278592375367
GO:BP GO:1901224 positive regulation of NIK/NF-kappaB signaling 0.0187146197471274 68 62 3 0.0483870967741935 0.0441176470588235
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 0.0187146197471274 1639 32 9 0.28125 0.00549115314215985
GO:BP GO:1904950 negative regulation of establishment of protein localization 0.0187146197471274 139 111 5 0.045045045045045 0.0359712230215827
GO:BP GO:1901222 regulation of NIK/NF-kappaB signaling 0.0187146197471274 113 81 4 0.0493827160493827 0.0353982300884956
GO:BP GO:0038061 NIK/NF-kappaB signaling 0.0195586794210951 194 81 5 0.0617283950617284 0.0257731958762887
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0199773986182474 1160 81 13 0.160493827160494 0.0112068965517241
GO:BP GO:0045892 negative regulation of transcription, DNA-templated 0.0200206662256279 1337 32 8 0.25 0.00598354525056096
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 0.0201388491763061 1339 32 8 0.25 0.00597460791635549
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 0.0201982221691565 1341 32 8 0.25 0.00596569724086503
GO:BP GO:0048523 negative regulation of cellular process 0.0201982221691565 5139 82 36 0.439024390243902 0.00700525394045534
GO:BP GO:0034121 regulation of toll-like receptor signaling pathway 0.0202081308823743 79 56 3 0.0535714285714286 0.0379746835443038
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 0.0203477828679338 4199 34 16 0.470588235294118 0.0038104310550131
GO:BP GO:0070647 protein modification by small protein conjugation or removal 0.0217448978771232 1184 141 19 0.134751773049645 0.0160472972972973
GO:BP GO:0051252 regulation of RNA metabolic process 0.0221652503086367 3822 34 15 0.441176470588235 0.00392464678178964
GO:BP GO:0043434 response to peptide hormone 0.0221851208837846 462 111 9 0.0810810810810811 0.0194805194805195
GO:BP GO:0051100 negative regulation of binding 0.0222078290472999 163 29 3 0.103448275862069 0.0184049079754601
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 0.0222078290472999 1707 32 9 0.28125 0.00527240773286467
GO:BP GO:0008286 insulin receptor signaling pathway 0.0222078290472999 148 111 5 0.045045045045045 0.0337837837837838
GO:BP GO:0002224 toll-like receptor signaling pathway 0.0225225464918556 161 62 4 0.0645161290322581 0.0248447204968944
GO:BP GO:0018130 heterocycle biosynthetic process 0.0226542509867322 4269 34 16 0.470588235294118 0.003747950339658
GO:BP GO:0032509 endosome transport via multivesicular body sorting pathway 0.0226542509867322 34 140 3 0.0214285714285714 0.0882352941176471
GO:BP GO:0002700 regulation of production of molecular mediator of immune response 0.0228076855121449 148 68 4 0.0588235294117647 0.027027027027027
GO:BP GO:0019438 aromatic compound biosynthetic process 0.0228076855121449 4278 34 16 0.470588235294118 0.0037400654511454
GO:BP GO:0006913 nucleocytoplasmic transport 0.0228076855121449 354 29 4 0.137931034482759 0.0112994350282486
GO:BP GO:0051169 nuclear transport 0.0233003764784172 357 29 4 0.137931034482759 0.0112044817927171
GO:BP GO:0006974 cellular response to DNA damage stimulus 0.0238235350394579 888 29 6 0.206896551724138 0.00675675675675676
GO:BP GO:0009890 negative regulation of biosynthetic process 0.0238235350394579 1740 32 9 0.28125 0.00517241379310345
GO:BP GO:0045637 regulation of myeloid cell differentiation 0.0238235350394579 263 19 3 0.157894736842105 0.0114068441064639
GO:BP GO:0031397 negative regulation of protein ubiquitination 0.0242356449882598 83 124 4 0.032258064516129 0.0481927710843374
GO:BP GO:0016070 RNA metabolic process 0.0245607218445004 4710 131 49 0.374045801526718 0.0104033970276008
GO:BP GO:0032102 negative regulation of response to external stimulus 0.0245607218445004 406 62 6 0.0967741935483871 0.0147783251231527
GO:BP GO:0090304 nucleic acid metabolic process 0.0248886425900501 5226 34 18 0.529411764705882 0.0034443168771527
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0254335657908719 2541 3 3 1 0.00118063754427391
GO:BP GO:1901362 organic cyclic compound biosynthetic process 0.0269982044179794 4439 146 51 0.349315068493151 0.0114890741157918
GO:BP GO:0051253 negative regulation of RNA metabolic process 0.0271324926645611 1445 32 8 0.25 0.0055363321799308
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.0272759895779068 5746 34 19 0.558823529411765 0.00330664810302819
GO:BP GO:0031329 regulation of cellular catabolic process 0.0274055014091031 866 141 15 0.106382978723404 0.0173210161662818
GO:BP GO:0006611 protein export from nucleus 0.0276098712237216 185 29 3 0.103448275862069 0.0162162162162162
GO:BP GO:0031323 regulation of cellular metabolic process 0.0283805293915949 6269 34 20 0.588235294117647 0.00319030148349019
GO:BP GO:0051246 regulation of protein metabolic process 0.0283805293915949 2704 3 3 1 0.0011094674556213
GO:BP GO:0080090 regulation of primary metabolic process 0.0288568069784177 6053 113 52 0.460176991150442 0.00859078143069552
GO:BP GO:0042304 regulation of fatty acid biosynthetic process 0.0288568069784177 57 97 3 0.0309278350515464 0.0526315789473684
GO:BP GO:0010648 negative regulation of cell communication 0.0290769348166882 1468 120 19 0.158333333333333 0.0129427792915531
GO:BP GO:0019941 modification-dependent protein catabolic process 0.0291021393144592 662 18 4 0.222222222222222 0.00604229607250755
GO:BP GO:1901653 cellular response to peptide 0.0292457444915329 408 111 8 0.0720720720720721 0.0196078431372549
GO:BP GO:0071985 multivesicular body sorting pathway 0.0292457444915329 40 140 3 0.0214285714285714 0.075
GO:BP GO:0023057 negative regulation of signaling 0.0292894852020803 1471 120 19 0.158333333333333 0.0129163834126445
GO:BP GO:0035329 hippo signaling 0.0297209834027865 47 120 3 0.025 0.0638297872340425
GO:BP GO:0032446 protein modification by small protein conjugation 0.0298666597540391 973 141 16 0.113475177304965 0.0164439876670093
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.0299228998197596 5848 34 19 0.558823529411765 0.00324897400820793
GO:BP GO:0043632 modification-dependent macromolecule catabolic process 0.0302229548173659 673 18 4 0.222222222222222 0.00594353640416048
GO:BP GO:0051693 actin filament capping 0.0302947851350554 44 130 3 0.0230769230769231 0.0681818181818182
GO:BP GO:0006401 RNA catabolic process 0.0302947851350554 424 108 8 0.0740740740740741 0.0188679245283019
GO:BP GO:0019217 regulation of fatty acid metabolic process 0.0306000101974436 105 111 4 0.036036036036036 0.0380952380952381
GO:BP GO:0046782 regulation of viral transcription 0.0306000101974436 41 141 3 0.0212765957446809 0.0731707317073171
GO:BP GO:0016567 protein ubiquitination 0.0310088310046882 892 141 15 0.106382978723404 0.0168161434977578
GO:BP GO:0009725 response to hormone 0.0312439714926572 921 111 13 0.117117117117117 0.0141150922909881
GO:BP GO:0051168 nuclear export 0.0312439714926572 204 29 3 0.103448275862069 0.0147058823529412
GO:BP GO:0046483 heterocycle metabolic process 0.0315455131726588 5904 34 19 0.558823529411765 0.00321815718157182
GO:BP GO:2000116 regulation of cysteine-type endopeptidase activity 0.0316028302578387 240 25 3 0.12 0.0125
GO:BP GO:1903321 negative regulation of protein modification by small protein conjugation or removal 0.0316181196510312 96 124 4 0.032258064516129 0.0416666666666667
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 0.0316567358966221 4091 34 15 0.441176470588235 0.00366658518699584
GO:BP GO:0009057 macromolecule catabolic process 0.0321196794029003 1468 140 21 0.15 0.0143051771117166
GO:BP GO:0018108 peptidyl-tyrosine phosphorylation 0.0329139602503853 385 32 4 0.125 0.0103896103896104
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 0.0330794394561733 1548 32 8 0.25 0.00516795865633075
GO:BP GO:0018212 peptidyl-tyrosine modification 0.0333439021381821 388 32 4 0.125 0.0103092783505155
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.0333979242520579 6603 25 16 0.64 0.00242314099651673
GO:BP GO:0048585 negative regulation of response to stimulus 0.0335451509321399 1733 120 21 0.175 0.0121177149451818
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.0336819432729862 5956 34 19 0.558823529411765 0.0031900604432505
GO:BP GO:0048872 homeostasis of number of cells 0.0339882937282157 261 24 3 0.125 0.0114942528735632
GO:BP GO:1901699 cellular response to nitrogen compound 0.0340447290057656 724 111 11 0.0990990990990991 0.0151933701657459
GO:BP GO:0072006 nephron development 0.0340480376281703 142 87 4 0.0459770114942529 0.028169014084507
GO:BP GO:0030835 negative regulation of actin filament depolymerization 0.0342594168297412 48 130 3 0.0230769230769231 0.0625
GO:BP GO:0030336 negative regulation of cell migration 0.0344323414285321 353 81 6 0.0740740740740741 0.0169971671388102
GO:BP GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 0.03465832896031 198 32 3 0.09375 0.0151515151515152
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 0.0362028959905181 174 37 3 0.0810810810810811 0.0172413793103448
GO:BP GO:0051603 proteolysis involved in cellular protein catabolic process 0.0365272303131157 750 140 13 0.0928571428571429 0.0173333333333333
GO:BP GO:0048524 positive regulation of viral process 0.0365272303131157 91 140 4 0.0285714285714286 0.043956043956044
GO:BP GO:0007519 skeletal muscle tissue development 0.0392955200868924 160 130 5 0.0384615384615385 0.03125
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 0.0396522041944481 182 37 3 0.0810810810810811 0.0164835164835165
GO:BP GO:1903827 regulation of cellular protein localization 0.0396645785347227 572 87 8 0.0919540229885057 0.013986013986014
GO:BP GO:2000146 negative regulation of cell motility 0.0396645785347227 369 81 6 0.0740740740740741 0.016260162601626
GO:BP GO:0032870 cellular response to hormone stimulus 0.0400717475367414 645 111 10 0.0900900900900901 0.0155038759689922
GO:BP GO:0061028 establishment of endothelial barrier 0.0400868257237153 50 136 3 0.0220588235294118 0.06
GO:BP GO:0050789 regulation of biological process 0.0400878400809953 12091 113 88 0.778761061946903 0.0072781407658589
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.0400878400809953 1455 92 15 0.16304347826087 0.0103092783505155
GO:BP GO:0002702 positive regulation of production of molecular mediator of immune response 0.0400878400809953 100 68 3 0.0441176470588235 0.03
GO:BP GO:0043066 negative regulation of apoptotic process 0.0400878400809953 921 24 5 0.208333333333333 0.00542888165038002
GO:BP GO:0062012 regulation of small molecule metabolic process 0.0406821377370715 447 112 8 0.0714285714285714 0.0178970917225951
GO:BP GO:0010468 regulation of gene expression 0.0411506492241601 5196 104 42 0.403846153846154 0.00808314087759815
GO:BP GO:1901652 response to peptide 0.0413762387736545 551 111 9 0.0810810810810811 0.0163339382940109
GO:BP GO:0034655 nucleobase-containing compound catabolic process 0.0414807589375889 567 108 9 0.0833333333333333 0.0158730158730159
GO:BP GO:0010565 regulation of cellular ketone metabolic process 0.0414810037663531 194 111 5 0.045045045045045 0.0257731958762887
GO:BP GO:0051271 negative regulation of cellular component movement 0.0414810037663531 377 81 6 0.0740740740740741 0.0159151193633952
GO:BP GO:0043069 negative regulation of programmed cell death 0.0416026979399139 943 24 5 0.208333333333333 0.00530222693531283
GO:BP GO:0044267 cellular protein metabolic process 0.0416026979399139 5229 4 4 1 0.000764964620386307
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 0.0416026979399139 192 37 3 0.0810810810810811 0.015625
GO:BP GO:0051494 negative regulation of cytoskeleton organization 0.0416026979399139 166 130 5 0.0384615384615385 0.0301204819277108
GO:BP GO:1902531 regulation of intracellular signal transduction 0.0416026979399139 1842 147 25 0.170068027210884 0.0135722041259501
GO:BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 0.0423461967495545 159 87 4 0.0459770114942529 0.0251572327044025
GO:BP GO:0002703 regulation of leukocyte mediated immunity 0.042775115121265 205 68 4 0.0588235294117647 0.0195121951219512
GO:BP GO:0044257 cellular protein catabolic process 0.0430883840501974 813 18 4 0.222222222222222 0.00492004920049201
GO:BP GO:0051239 regulation of multicellular organismal process 0.0432212239940706 2861 92 24 0.260869565217391 0.00838867528836071
GO:BP GO:0060548 negative regulation of cell death 0.0434344345582488 1038 118 14 0.11864406779661 0.0134874759152216
GO:BP GO:1902904 negative regulation of supramolecular fiber organization 0.0437488244401744 170 130 5 0.0384615384615385 0.0294117647058824
GO:BP GO:0060538 skeletal muscle organ development 0.0437488244401744 170 130 5 0.0384615384615385 0.0294117647058824
GO:BP GO:1901360 organic cyclic compound metabolic process 0.043963837746798 6201 34 19 0.558823529411765 0.00306402193194646
GO:BP GO:0030834 regulation of actin filament depolymerization 0.0446529159838248 57 130 3 0.0230769230769231 0.0526315789473684
GO:BP GO:0006402 mRNA catabolic process 0.0449445566493496 384 108 7 0.0648148148148148 0.0182291666666667
GO:BP GO:0090305 nucleic acid phosphodiester bond hydrolysis 0.0449797855359472 307 103 6 0.058252427184466 0.0195439739413681
GO:BP GO:0002699 positive regulation of immune effector process 0.047035184911167 215 68 4 0.0588235294117647 0.0186046511627907
GO:BP GO:1900076 regulation of cellular response to insulin stimulus 0.0471341555963574 69 111 3 0.027027027027027 0.0434782608695652
GO:BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 0.0471341555963574 162 141 5 0.0354609929078014 0.0308641975308642
GO:BP GO:0061013 regulation of mRNA catabolic process 0.0479135533729745 213 108 5 0.0462962962962963 0.0234741784037559
GO:BP GO:0015031 protein transport 0.0479426217473317 1929 29 8 0.275862068965517 0.00414722654224987
GO:BP GO:0040013 negative regulation of locomotion 0.0481851843973728 401 81 6 0.0740740740740741 0.0149625935162095
GO:BP GO:1900182 positive regulation of protein localization to nucleus 0.0484099759455056 90 87 3 0.0344827586206897 0.0333333333333333
GO:BP GO:1903706 regulation of hemopoiesis 0.0484099759455056 424 19 3 0.157894736842105 0.00707547169811321
GO:BP GO:0071407 cellular response to organic cyclic compound 0.0484099759455056 587 91 8 0.0879120879120879 0.0136286201022147
GO:BP GO:0046626 regulation of insulin receptor signaling pathway 0.0487392883109184 71 111 3 0.027027027027027 0.0422535211267606
GO:BP GO:0048863 stem cell differentiation 0.0491302040479969 258 31 3 0.0967741935483871 0.0116279069767442
GO:BP GO:0042981 regulation of apoptotic process 0.0492849431722752 1549 29 7 0.241379310344828 0.00451904454486766
GO:BP GO:0009889 regulation of biosynthetic process 0.0496551845617468 4361 146 48 0.328767123287671 0.0110066498509516
GO:BP GO:0009165 nucleotide biosynthetic process 0.0496837574811559 269 30 3 0.1 0.0111524163568773
GO:BP GO:0072080 nephron tubule development 0.0498655134562365 92 87 3 0.0344827586206897 0.0326086956521739
GO:BP GO:0046700 heterocycle catabolic process 0.0498655134562365 602 108 9 0.0833333333333333 0.0149501661129568
GO:BP GO:0065008 regulation of biological quality 0.0499775043874032 4131 30 13 0.433333333333333 0.00314693778746066
GO:BP GO:0030042 actin filament depolymerization 0.0499818869870037 62 130 3 0.0230769230769231 0.0483870967741935
GO:CC GO:0005829 cytosol 1.57363550044644e-07 5303 120 66 0.55 0.012445785404488
GO:CC GO:0005737 cytoplasm 6.73526034990815e-05 11911 141 116 0.822695035460993 0.00973889681806733
GO:CC GO:0005622 intracellular anatomical structure 0.00131009798179522 14790 141 129 0.914893617021277 0.00872210953346856
GO:CC GO:0031981 nuclear lumen 0.00131009798179522 4444 62 30 0.483870967741935 0.00675067506750675
GO:CC GO:0005654 nucleoplasm 0.00192067775493935 4102 62 28 0.451612903225806 0.0068259385665529
GO:CC GO:0005634 nucleus 0.00383965473834924 7592 60 39 0.65 0.00513698630136986
GO:CC GO:0043233 organelle lumen 0.00660739088657246 5565 62 32 0.516129032258065 0.00575022461814915
GO:CC GO:0031974 membrane-enclosed lumen 0.00660739088657246 5565 62 32 0.516129032258065 0.00575022461814915
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.00697363380854115 11296 60 49 0.816666666666667 0.00433781869688385
GO:CC GO:0070013 intracellular organelle lumen 0.00815013527457206 5402 62 31 0.5 0.00573861532765642
GO:CC GO:0048471 perinuclear region of cytoplasm 0.00924889646583716 735 17 5 0.294117647058824 0.00680272108843537
GO:CC GO:0043229 intracellular organelle 0.00924889646583716 12491 63 54 0.857142857142857 0.00432311264110159
GO:CC GO:0030670 phagocytic vesicle membrane 0.0104366276998568 76 37 3 0.0810810810810811 0.0394736842105263
GO:CC GO:0045335 phagocytic vesicle 0.0104610193237018 137 50 4 0.08 0.0291970802919708
GO:CC GO:0031966 mitochondrial membrane 0.0121635027191584 746 5 3 0.6 0.00402144772117962
GO:CC GO:0005740 mitochondrial envelope 0.0131378975544265 797 5 3 0.6 0.00376411543287327
GO:CC GO:0005766 primary lysosome 0.0131378975544265 154 88 5 0.0568181818181818 0.0324675324675325
GO:CC GO:0043227 membrane-bounded organelle 0.0131378975544265 12858 60 52 0.866666666666667 0.00404417483278892
GO:CC GO:0042582 azurophil granule 0.0131378975544265 154 88 5 0.0568181818181818 0.0324675324675325
GO:CC GO:0043226 organelle 0.0156546520099021 14008 63 57 0.904761904761905 0.00406910336950314
GO:CC GO:0005730 nucleolus 0.0276053566099487 955 56 9 0.160714285714286 0.00942408376963351
GO:CC GO:0031967 organelle envelope 0.0320100391108933 1237 5 3 0.6 0.00242522231204527
GO:CC GO:0031975 envelope 0.0320100391108933 1237 5 3 0.6 0.00242522231204527
GO:CC GO:0030666 endocytic vesicle membrane 0.0432866184448465 159 37 3 0.0810810810810811 0.0188679245283019
GO:CC GO:0005739 mitochondrion 0.0432866184448465 1673 30 8 0.266666666666667 0.00478182904961148
GO:MF GO:0003725 double-stranded RNA binding 3.78176914731116e-09 77 68 9 0.132352941176471 0.116883116883117
GO:MF GO:0001730 2'-5'-oligoadenylate synthetase activity 8.42845627091442e-09 4 48 4 0.0833333333333333 1
GO:MF GO:0003950 NAD+ ADP-ribosyltransferase activity 6.59889347684542e-06 27 142 6 0.0422535211267606 0.222222222222222
GO:MF GO:1990404 protein ADP-ribosylase activity 1.06108004674219e-05 16 142 5 0.0352112676056338 0.3125
GO:MF GO:0003723 RNA binding 8.90650889012528e-05 1943 96 27 0.28125 0.0138960370560988
GO:MF GO:0070566 adenylyltransferase activity 0.000108845021478919 33 48 4 0.0833333333333333 0.121212121212121
GO:MF GO:0003724 RNA helicase activity 0.000226472397641842 76 103 6 0.058252427184466 0.0789473684210526
GO:MF GO:0016763 transferase activity, transferring pentosyl groups 0.000226472397641842 56 142 6 0.0422535211267606 0.107142857142857
GO:MF GO:0004386 helicase activity 0.00140460071754212 162 103 7 0.0679611650485437 0.0432098765432099
GO:MF GO:0044389 ubiquitin-like protein ligase binding 0.00175666834909381 314 99 9 0.0909090909090909 0.0286624203821656
GO:MF GO:0005159 insulin-like growth factor receptor binding 0.00339139014221592 16 111 3 0.027027027027027 0.1875
GO:MF GO:0035639 purine ribonucleoside triphosphate binding 0.00351388962567262 1847 47 14 0.297872340425532 0.00757985923118571
GO:MF GO:0032553 ribonucleotide binding 0.00412413546056052 1935 47 14 0.297872340425532 0.00723514211886305
GO:MF GO:0032555 purine ribonucleotide binding 0.00412413546056052 1918 47 14 0.297872340425532 0.0072992700729927
GO:MF GO:1901363 heterocyclic compound binding 0.00412413546056052 6228 30 20 0.666666666666667 0.00321130378933847
GO:MF GO:0003712 transcription coregulator activity 0.00412413546056052 506 146 13 0.089041095890411 0.0256916996047431
GO:MF GO:0017076 purine nucleotide binding 0.00412413546056052 1933 47 14 0.297872340425532 0.00724262803931712
GO:MF GO:0097159 organic cyclic compound binding 0.00449061148564043 6309 30 20 0.666666666666667 0.00317007449675067
GO:MF GO:0097367 carbohydrate derivative binding 0.00584403420721599 2285 47 15 0.319148936170213 0.00656455142231947
GO:MF GO:0005515 protein binding 0.00592604076676113 14767 122 111 0.909836065573771 0.00751676034401029
GO:MF GO:0003727 single-stranded RNA binding 0.00595906599617608 92 68 4 0.0588235294117647 0.0434782608695652
GO:MF GO:0005158 insulin receptor binding 0.00613936056856024 24 111 3 0.027027027027027 0.125
GO:MF GO:0016779 nucleotidyltransferase activity 0.00622545704852106 135 48 4 0.0833333333333333 0.0296296296296296
GO:MF GO:0043168 anion binding 0.00893883466554894 2418 47 15 0.319148936170213 0.00620347394540943
GO:MF GO:0017111 nucleoside-triphosphatase activity 0.00895366576535408 872 86 12 0.13953488372093 0.0137614678899083
GO:MF GO:0000166 nucleotide binding 0.00895366576535408 2171 47 14 0.297872340425532 0.0064486411791801
GO:MF GO:1901265 nucleoside phosphate binding 0.00895366576535408 2172 47 14 0.297872340425532 0.00644567219152855
GO:MF GO:0003676 nucleic acid binding 0.00978560342619164 4276 50 22 0.44 0.00514499532273152
GO:MF GO:0016462 pyrophosphatase activity 0.0121385307889033 928 86 12 0.13953488372093 0.0129310344827586
GO:MF GO:0016887 ATPase activity 0.0121385307889033 488 117 10 0.0854700854700855 0.0204918032786885
GO:MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0121385307889033 930 86 12 0.13953488372093 0.0129032258064516
GO:MF GO:0016817 hydrolase activity, acting on acid anhydrides 0.0121385307889033 930 86 12 0.13953488372093 0.0129032258064516
GO:MF GO:0140297 DNA-binding transcription factor binding 0.0121385307889033 391 98 8 0.0816326530612245 0.020460358056266
GO:MF GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 0.013798240495557 281 54 5 0.0925925925925926 0.0177935943060498
GO:MF GO:0016787 hydrolase activity 0.014073233973787 2615 86 23 0.267441860465116 0.00879541108986616
GO:MF GO:0042802 identical protein binding 0.0153005937688805 2067 13 6 0.461538461538462 0.00290275761973875
GO:MF GO:0140098 catalytic activity, acting on RNA 0.0153005937688805 395 103 8 0.0776699029126214 0.020253164556962
GO:MF GO:0003713 transcription coactivator activity 0.0153005937688805 280 146 8 0.0547945205479452 0.0285714285714286
GO:MF GO:0036094 small molecule binding 0.0203972300335754 2506 47 14 0.297872340425532 0.00558659217877095
GO:MF GO:0003824 catalytic activity 0.0203972300335754 5896 86 40 0.465116279069767 0.0067842605156038
GO:MF GO:0032813 tumor necrosis factor receptor superfamily binding 0.021103601283808 49 108 3 0.0277777777777778 0.0612244897959184
GO:MF GO:0008134 transcription factor binding 0.021103601283808 676 98 10 0.102040816326531 0.014792899408284
GO:MF GO:0005524 ATP binding 0.0241873028779165 1501 47 10 0.212765957446809 0.00666222518321119
GO:MF GO:0043167 ion binding 0.0241873028779165 6057 70 34 0.485714285714286 0.00561333993726267
GO:MF GO:0140110 transcription regulator activity 0.0273290135672066 1935 146 26 0.178082191780822 0.0134366925064599
GO:MF GO:0032559 adenyl ribonucleotide binding 0.0296550256329729 1565 47 10 0.212765957446809 0.00638977635782748
GO:MF GO:0030554 adenyl nucleotide binding 0.0310083537092178 1578 47 10 0.212765957446809 0.00633713561470215
GO:MF GO:0005488 binding 0.0384748837131774 17074 78 77 0.987179487179487 0.00450978095349654
GO:MF GO:0030374 nuclear receptor coactivator activity 0.0390725335090661 55 144 3 0.0208333333333333 0.0545454545454545
GO:MF GO:0004197 cysteine-type endopeptidase activity 0.0390725335090661 121 125 4 0.032 0.0330578512396694
GO:MF GO:0035591 signaling adaptor activity 0.0390725335090661 70 111 3 0.027027027027027 0.0428571428571429
GO:MF GO:0003714 transcription corepressor activity 0.0390725335090661 187 124 5 0.0403225806451613 0.0267379679144385
GO:MF GO:0004842 ubiquitin-protein transferase activity 0.047097482752362 442 104 7 0.0673076923076923 0.0158371040723982
HP HP:0030355 Abnormal serum interferon-gamma level 2.63026563054248e-05 11 44 5 0.113636363636364 0.454545454545455
HP HP:0030354 Abnormal serum interferon level 2.63026563054248e-05 11 44 5 0.113636363636364 0.454545454545455
HP HP:0011111 Abnormality of immune serum protein physiology 0.00110077252748278 24 44 5 0.113636363636364 0.208333333333333
HP HP:0011112 Abnormality of serum cytokine level 0.00110077252748278 23 44 5 0.113636363636364 0.217391304347826
HP HP:0011834 Moyamoya phenomenon 0.00124684315130233 12 44 4 0.0909090909090909 0.333333333333333
HP HP:0009704 Chronic CSF lymphocytosis 0.00621089762164992 7 44 3 0.0681818181818182 0.428571428571429
HP HP:0009709 Increased CSF interferon alpha 0.00621089762164992 7 44 3 0.0681818181818182 0.428571428571429
HP HP:0009710 Chilblains 0.00621089762164992 7 44 3 0.0681818181818182 0.428571428571429
HP HP:0030356 Increased serum interferon-gamma level 0.00857708063955703 8 44 3 0.0681818181818182 0.375
HP HP:0012490 Panniculitis 0.00857708063955703 22 44 4 0.0909090909090909 0.181818181818182
HP HP:0005550 Chronic lymphatic leukemia 0.0106929170016805 9 44 3 0.0681818181818182 0.333333333333333
HP HP:0003207 Arterial calcification 0.0131042832122537 26 44 4 0.0909090909090909 0.153846153846154
HP HP:0040140 Degeneration of the striatum 0.0131042832122537 10 44 3 0.0681818181818182 0.3
HP HP:0004934 Vascular calcification 0.0189219632677343 29 44 4 0.0909090909090909 0.137931034482759
HP HP:0007052 Multifocal cerebral white matter abnormalities 0.023093175714038 13 44 3 0.0681818181818182 0.230769230769231
HP HP:0004809 Neonatal alloimmune thrombocytopenia 0.023093175714038 13 44 3 0.0681818181818182 0.230769230769231
HP HP:0100614 Myositis 0.023093175714038 32 44 4 0.0909090909090909 0.125
HP HP:0003683 Large beaked nose 0.0234525473143997 14 44 3 0.0681818181818182 0.214285714285714
HP HP:0007076 Extrapyramidal muscular rigidity 0.0234525473143997 14 44 3 0.0681818181818182 0.214285714285714
HP HP:0009145 Abnormal cerebral artery morphology 0.0234525473143997 61 44 5 0.113636363636364 0.0819672131147541
HP HP:0011915 Cardiovascular calcification 0.0234525473143997 33 44 4 0.0909090909090909 0.121212121212121
HP HP:0200149 CSF lymphocytic pleiocytosis 0.0324947782243717 16 44 3 0.0681818181818182 0.1875
HP HP:0030038 Enchondroma 0.0324947782243717 16 44 3 0.0681818181818182 0.1875
HP HP:0001955 Unexplained fevers 0.0375556349141585 17 44 3 0.0681818181818182 0.176470588235294
HP HP:0012229 CSF pleocytosis 0.042968730808126 18 44 3 0.0681818181818182 0.166666666666667
HP HP:0001063 Acrocyanosis 0.048728005248531 19 44 3 0.0681818181818182 0.157894736842105
KEGG KEGG:05162 Measles 1.6920610232168e-07 139 30 9 0.3 0.0647482014388489
KEGG KEGG:05160 Hepatitis C 2.50048256707707e-07 157 30 9 0.3 0.0573248407643312
KEGG KEGG:05164 Influenza A 3.1961968392136e-07 169 30 9 0.3 0.0532544378698225
KEGG KEGG:05171 Coronavirus disease - COVID-19 3.64713287842899e-06 231 30 9 0.3 0.038961038961039
KEGG KEGG:05169 Epstein-Barr virus infection 5.74846263360352e-06 198 37 9 0.243243243243243 0.0454545454545455
KEGG KEGG:05168 Herpes simplex virus 1 infection 0.000797672787421686 494 42 11 0.261904761904762 0.0222672064777328
KEGG KEGG:04621 NOD-like receptor signaling pathway 0.000851692381684457 177 30 6 0.2 0.0338983050847458
KEGG KEGG:05165 Human papillomavirus infection 0.0122885200167475 331 27 6 0.222222222222222 0.0181268882175227
KEGG KEGG:04622 RIG-I-like receptor signaling pathway 0.0282888133300933 70 100 5 0.05 0.0714285714285714
MIRNA MIRNA:hsa-miR-146a-5p hsa-miR-146a-5p 1.67315657550254e-16 200 62 18 0.290322580645161 0.09
REAC REAC:R-HSA-909733 Interferon alpha/beta signaling 1.96543235890444e-35 66 65 24 0.369230769230769 0.363636363636364
REAC REAC:R-HSA-913531 Interferon Signaling 4.26851189745555e-33 191 73 31 0.424657534246575 0.162303664921466
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 4.48672271091997e-15 842 75 33 0.44 0.0391923990498812
REAC REAC:R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 1.46876483388669e-14 78 73 14 0.191780821917808 0.179487179487179
REAC REAC:R-HSA-168256 Immune System 3.29378250407178e-09 2139 61 36 0.590163934426229 0.0168302945301543
REAC REAC:R-HSA-1169408 ISG15 antiviral mechanism 3.29378250407178e-09 70 73 10 0.136986301369863 0.142857142857143
REAC REAC:R-HSA-8983711 OAS antiviral response 8.78494017909348e-08 9 68 5 0.0735294117647059 0.555555555555556
REAC REAC:R-HSA-877300 Interferon gamma signaling 1.25931350873131e-06 87 141 11 0.0780141843971631 0.126436781609195
REAC REAC:R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 1.48400508872477e-05 34 85 6 0.0705882352941176 0.176470588235294
REAC REAC:R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.000124545707700073 76 85 7 0.0823529411764706 0.0921052631578947
REAC REAC:R-HSA-9683610 Maturation of nucleoprotein 0.000292942065649067 10 142 4 0.028169014084507 0.4
REAC REAC:R-HSA-918233 TRAF3-dependent IRF activation pathway 0.00383254715550171 14 68 3 0.0441176470588235 0.214285714285714
REAC REAC:R-HSA-197264 Nicotinamide salvaging 0.00416281599763171 19 142 4 0.028169014084507 0.210526315789474
REAC REAC:R-HSA-9683701 Translation of structural proteins 0.0185855481149322 28 142 4 0.028169014084507 0.142857142857143
REAC REAC:R-HSA-933541 TRAF6 mediated IRF7 activation 0.0232024617170815 27 68 3 0.0441176470588235 0.111111111111111
REAC REAC:R-HSA-196807 Nicotinate metabolism 0.0242212667453369 31 142 4 0.028169014084507 0.129032258064516
REAC REAC:R-HSA-191273 Cholesterol biosynthesis 0.0475507857863918 24 112 3 0.0267857142857143 0.125
TF TF:M04020 Factor: IRF8; motif: NCGAAACCGAAACT 2.45025718295032e-34 992 141 58 0.411347517730496 0.0584677419354839
TF TF:M11685 Factor: IRF-8; motif: NCGAAACYGAAACYN 1.53152703453386e-32 1617 147 69 0.469387755102041 0.0426716141001855
TF TF:M11671 Factor: IRF-5; motif: NCGAAACCGAAACY 6.70788874008028e-32 389 61 30 0.491803278688525 0.077120822622108
TF TF:M11679 Factor: IRF-7; motif: NCGAAANCGAAANYN 1.67347517245913e-29 622 93 38 0.408602150537634 0.0610932475884244
TF TF:M04015 Factor: IRF-4; motif: NCGAAACCGAAACYA 4.2606566560278e-29 2038 141 70 0.49645390070922 0.0343473994111874
TF TF:M11670 Factor: IRF-5; motif: NYGAAACCGAAACY 4.2606566560278e-29 871 147 51 0.346938775510204 0.0585533869115959
TF TF:M11685_1 Factor: IRF-8; motif: NCGAAACYGAAACYN; match class: 1 1.8237695707621e-27 118 86 22 0.255813953488372 0.186440677966102
TF TF:M04018 Factor: IRF7; motif: NCGAAARYGAAANT 6.7010043620082e-26 619 93 35 0.376344086021505 0.0565428109854604
TF TF:M11664 Factor: IRF-2; motif: NGAAASYGAAAS 6.90364947362976e-26 1651 147 62 0.421768707482993 0.0375529981829194
TF TF:M04014 Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR 7.37215409253338e-25 278 147 31 0.210884353741497 0.111510791366906
TF TF:M11680 Factor: IRF-9; motif: NYGAAACYGAAACYN 3.07198279150778e-24 128 93 21 0.225806451612903 0.1640625
TF TF:M10080 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN 3.23106317520299e-24 356 92 28 0.304347826086957 0.0786516853932584
TF TF:M11681 Factor: IRF-9; motif: NCGAAACYGAAACYN 2.33203991854743e-23 97 93 19 0.204301075268817 0.195876288659794
TF TF:M08887 Factor: IRF; motif: NNGAAANTGAAANN 5.03353002254683e-23 1267 108 45 0.416666666666667 0.0355169692186267
TF TF:M11665 Factor: IRF-2; motif: NGAAASYGAAAS 5.03353002254683e-23 2396 76 48 0.631578947368421 0.0200333889816361
TF TF:M11687 Factor: IRF-4; motif: NCGAAACCGAAACYN 7.40082912556339e-23 3595 138 80 0.579710144927536 0.0222531293463143
TF TF:M09957 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN 1.79475640027924e-22 272 86 24 0.27906976744186 0.0882352941176471
TF TF:M00453_1 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN; match class: 1 3.46808313264035e-22 332 74 24 0.324324324324324 0.072289156626506
TF TF:M04016 Factor: IRF5; motif: CCGAAACCGAAACY 1.49119568889567e-21 314 141 29 0.205673758865248 0.0923566878980892
TF TF:M00453 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN 2.32072605101133e-21 3082 76 51 0.671052631578947 0.0165476963011032
TF TF:M09733 Factor: STAT2; motif: NRGAAANNGAAACTNA 2.44765037115705e-21 2842 86 53 0.616279069767442 0.0186488388458832
TF TF:M11683_1 Factor: IRF-8; motif: NCGAAACCGAAACYN; match class: 1 3.62936172306507e-21 814 93 34 0.365591397849462 0.0417690417690418
TF TF:M11682_1 Factor: IRF-8; motif: NYGAAASYGAAACYN; match class: 1 3.93349585350177e-21 543 74 27 0.364864864864865 0.0497237569060773
TF TF:M11672 Factor: IRF-5; motif: NCGAAACCGAAACY 3.93349585350177e-21 120 141 21 0.148936170212766 0.175
TF TF:M11664_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 4.02728702201053e-21 140 86 19 0.22093023255814 0.135714285714286
TF TF:M08887_1 Factor: IRF; motif: NNGAAANTGAAANN; match class: 1 1.12174793807758e-20 73 70 15 0.214285714285714 0.205479452054795
TF TF:M11683 Factor: IRF-8; motif: NCGAAACCGAAACYN 1.26359536409296e-20 4690 142 89 0.626760563380282 0.0189765458422175
TF TF:M11682 Factor: IRF-8; motif: NYGAAASYGAAACYN 1.49033995696462e-20 3795 147 82 0.557823129251701 0.0216073781291173
TF TF:M04015_1 Factor: IRF-4; motif: NCGAAACCGAAACYA; match class: 1 1.9433849439287e-20 158 99 20 0.202020202020202 0.126582278481013
TF TF:M08775_1 Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 2.40275593682471e-20 2761 147 70 0.476190476190476 0.025353132922854
TF TF:M11686 Factor: IRF-4; motif: NYGAAASYGAAACYN 5.09830013381017e-20 3391 93 58 0.623655913978495 0.0171040990858154
TF TF:M11684_1 Factor: IRF-8; motif: NYGAAACYGAAACTN; match class: 1 1.42268107009618e-19 832 76 30 0.394736842105263 0.0360576923076923
TF TF:M07216 Factor: IRF1; motif: NNNYASTTTCACTTTCNNTTT 2.17929082285177e-19 440 93 26 0.279569892473118 0.0590909090909091
TF TF:M00258 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC 3.8788578616954e-19 823 73 29 0.397260273972603 0.0352369380315917
TF TF:M11687_1 Factor: IRF-4; motif: NCGAAACCGAAACYN; match class: 1 5.29481449337911e-19 474 90 26 0.288888888888889 0.0548523206751055
TF TF:M04020_1 Factor: IRF8; motif: NCGAAACCGAAACT; match class: 1 9.46247299894136e-19 45 86 13 0.151162790697674 0.288888888888889
TF TF:M11677 Factor: IRF-3; motif: NGGAAACNGAAACCGAAACN 2.02529383065021e-18 470 86 25 0.290697674418605 0.0531914893617021
TF TF:M11670_1 Factor: IRF-5; motif: NYGAAACCGAAACY; match class: 1 4.20549452019413e-18 36 86 12 0.13953488372093 0.333333333333333
TF TF:M11686_1 Factor: IRF-4; motif: NYGAAASYGAAACYN; match class: 1 5.20286313295274e-18 452 74 23 0.310810810810811 0.0508849557522124
TF TF:M11665_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 5.49368377378807e-18 246 86 20 0.232558139534884 0.0813008130081301
TF TF:M07323 Factor: IRF-4; motif: KRAAMNGAAANYN 1.60504713041222e-17 938 105 34 0.323809523809524 0.0362473347547974
TF TF:M09733_1 Factor: STAT2; motif: NRGAAANNGAAACTNA; match class: 1 1.82407182948139e-17 367 73 21 0.287671232876712 0.0572207084468665
TF TF:M11684 Factor: IRF-8; motif: NYGAAACYGAAACTN 2.44434821144414e-17 4664 86 60 0.697674418604651 0.0128644939965695
TF TF:M07045 Factor: IRF-1; motif: NNRAAANNGAAASN 1.97366098219542e-16 535 74 23 0.310810810810811 0.0429906542056075
TF TF:M04788 Factor: IRF-1; motif: STTTCACTTTCNNT 2.01120500087785e-16 536 74 23 0.310810810810811 0.042910447761194
TF TF:M11673 Factor: IRF-5; motif: NCGAAACCGAAACY 3.96557807178442e-16 57 141 14 0.099290780141844 0.245614035087719
TF TF:M00699 Factor: ICSBP; motif: RAARTGAAACTG 5.0087906039982e-16 1184 73 30 0.410958904109589 0.0253378378378378
TF TF:M11676 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN 9.39245042310718e-15 562 83 23 0.27710843373494 0.0409252669039146
TF TF:M00772 Factor: IRF; motif: RRAANTGAAASYGNV 1.67289160359334e-14 1029 73 27 0.36986301369863 0.0262390670553936
TF TF:M11679_1 Factor: IRF-7; motif: NCGAAANCGAAANYN; match class: 1 3.76764959815808e-14 23 86 9 0.104651162790698 0.391304347826087
TF TF:M08775 Factor: IRF-2; motif: NAANYGAAASYR 6.20637739539088e-14 8370 74 65 0.878378378378378 0.00776583034647551
TF TF:M09629 Factor: IRF-1; motif: NAAANNGAAAGTGAAASTRN 2.50697963247459e-13 336 70 17 0.242857142857143 0.0505952380952381
TF TF:M00699_1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 1.12064243968072e-12 47 57 9 0.157894736842105 0.191489361702128
TF TF:M09956 Factor: IRF-1; motif: NAAANNGAAASTGAAASNRN 3.49649958955684e-11 317 70 15 0.214285714285714 0.0473186119873817
TF TF:M00258_1 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC; match class: 1 4.34416272382233e-10 30 61 7 0.114754098360656 0.233333333333333
TF TF:M10080_1 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN; match class: 1 4.62296054951009e-10 11 92 6 0.0652173913043478 0.545454545454545
TF TF:M00972 Factor: IRF; motif: RAAANTGAAAN 3.5887430219459e-09 1979 74 29 0.391891891891892 0.0146538655886812
TF TF:M09958 Factor: IRF-3; motif: RAAARGGAAANNGAAASNGA 4.01594202614756e-09 589 73 17 0.232876712328767 0.0288624787775891
TF TF:M00972_1 Factor: IRF; motif: RAAANTGAAAN; match class: 1 1.64161040483009e-08 205 70 11 0.157142857142857 0.0536585365853659
TF TF:M04017 Factor: IRF5; motif: NACCGAAACYA 2.95504619978731e-08 195 99 12 0.121212121212121 0.0615384615384615
TF TF:M11671_1 Factor: IRF-5; motif: NCGAAACCGAAACY; match class: 1 2.91607433841233e-07 14 86 5 0.0581395348837209 0.357142857142857
TF TF:M09745 Factor: HELIOS; motif: RNARRRGGAASTGARAN 3.63922190667997e-07 3582 16 14 0.875 0.00390843104410944
TF TF:M00772_1 Factor: IRF; motif: RRAANTGAAASYGNV; match class: 1 9.90807692459231e-07 57 147 8 0.054421768707483 0.140350877192982
TF TF:M09745_1 Factor: HELIOS; motif: RNARRRGGAASTGARAN; match class: 1 1.81096606238352e-06 495 14 7 0.5 0.0141414141414141
TF TF:M01279 Factor: IRF-3; motif: NBNBTTTCSCTTT 3.04953235648961e-06 1647 146 34 0.232876712328767 0.0206435944140862
TF TF:M11680_1 Factor: IRF-9; motif: NYGAAACYGAAACYN; match class: 1 1.11330608454206e-05 4 61 3 0.0491803278688525 0.75
TF TF:M00063 Factor: IRF-2; motif: GAAAAGYGAAASY 1.25267063808575e-05 685 26 9 0.346153846153846 0.0131386861313869
TF TF:M04788_1 Factor: IRF-1; motif: STTTCACTTTCNNT; match class: 1 1.85111176444092e-05 17 14 3 0.214285714285714 0.176470588235294
TF TF:M07045_1 Factor: IRF-1; motif: NNRAAANNGAAASN; match class: 1 2.59742960306038e-05 19 14 3 0.214285714285714 0.157894736842105
TF TF:M08295_1 Factor: FOXO1A:Elf-1; motif: NAGAAAACCGAANM; match class: 1 4.32262540326911e-05 4997 93 46 0.494623655913978 0.00920552331398839
TF TF:M11677_1 Factor: IRF-3; motif: NGGAAACNGAAACCGAAACN; match class: 1 4.93772518926383e-05 26 124 5 0.0403225806451613 0.192307692307692
TF TF:M07323_1 Factor: IRF-4; motif: KRAAMNGAAANYN; match class: 1 5.93926427670393e-05 39 35 4 0.114285714285714 0.102564102564103
TF TF:M00641 Factor: HSF; motif: TTCCMGARGYTTC 0.000101970150652066 3599 90 36 0.4 0.0100027785495971
TF TF:M11676_1 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN; match class: 1 0.000207724377710711 41 13 3 0.230769230769231 0.0731707317073171
TF TF:M09957_1 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN; match class: 1 0.000268588974846446 22 26 3 0.115384615384615 0.136363636363636
TF TF:M01665 Factor: IRF-8; motif: AGTTTCW 0.000331864581761871 4771 71 35 0.492957746478873 0.00733598826241878
TF TF:M04018_1 Factor: IRF7; motif: NCGAAARYGAAANT; match class: 1 0.000388942538504843 24 93 4 0.043010752688172 0.166666666666667
TF TF:M01665_1 Factor: IRF-8; motif: AGTTTCW; match class: 1 0.00104375214657415 721 23 7 0.304347826086957 0.00970873786407767
TF TF:M11674 Factor: IRF-3; motif: GCNGTTTCCWGGAAACNGAAAC 0.00138065503444196 4623 68 32 0.470588235294118 0.00692191217823924
TF TF:M00155 Factor: ARP-1; motif: TGARCCYTTGAMCCCW 0.00193342156176798 5581 54 30 0.555555555555556 0.00537538075613689
TF TF:M01882 Factor: IRF-2; motif: NNRAAAGTGAAASNNA 0.00208552016660433 258 14 4 0.285714285714286 0.0155038759689922
TF TF:M11453 Factor: ELFR; motif: AAMCAGGAAGTR 0.00240622763356277 488 65 9 0.138461538461538 0.0184426229508197
TF TF:M11678 Factor: IRF-7; motif: NNGAAAGTGAAANTR 0.0032810392361758 179 70 6 0.0857142857142857 0.0335195530726257
TF TF:M00774_1 Factor: NF-kappaB; motif: NGGGANTTYCCMNNNN; match class: 1 0.00410294787209707 192 42 5 0.119047619047619 0.0260416666666667
TF TF:M01023 Factor: HSF1; motif: NTTCTRGAAVNTTCTYM 0.00532422583564321 2721 121 33 0.272727272727273 0.0121278941565601
TF TF:M11363 Factor: c-MAF; motif: NTGCTGACNNWGCA 0.00606597332248104 422 66 8 0.121212121212121 0.018957345971564
TF TF:M00208_1 Factor: NF-kappaB; motif: NGGGACTTTCCA; match class: 1 0.00608269506505089 604 47 8 0.170212765957447 0.0132450331125828
TF TF:M09899 Factor: ehf; motif: NNANSAGGAAGTNNN 0.0090138694690358 457 65 8 0.123076923076923 0.0175054704595186
TF TF:M11458 Factor: nerf; motif: AANCMGGAAGTR 0.00998207406413229 505 60 8 0.133333333333333 0.0158415841584158
TF TF:M07223 Factor: Pax-5; motif: NNRNKCAGYSRAGCRTGAC 0.010000474683621 5600 84 40 0.476190476190476 0.00714285714285714
TF TF:M00194_1 Factor: NF-kappaB; motif: NGGGGAMTTTCCNN; match class: 1 0.010722236915232 385 42 6 0.142857142857143 0.0155844155844156
TF TF:M08510 Factor: TEF-3:Fli-1; motif: ACCGGAAATGCC 0.0116088636502778 7360 110 60 0.545454545454545 0.00815217391304348
TF TF:M09911_1 Factor: c-Ets-1; motif: NNRCMGGAAGTGG; match class: 1 0.0116088636502778 208 147 8 0.054421768707483 0.0384615384615385
TF TF:M10587 Factor: Barx-2; motif: NWWAAYMATTAN 0.0133460938240246 1776 20 8 0.4 0.0045045045045045
TF TF:M10586 Factor: Barx-2; motif: NWWAAYCATTAN 0.0133460938240246 1016 25 7 0.28 0.00688976377952756
TF TF:M09933_1 Factor: FOXP1; motif: TNTGTTTMY; match class: 1 0.0146511803443036 634 28 6 0.214285714285714 0.00946372239747634
TF TF:M11434 Factor: Elk-1; motif: NRSCGGAAGNN 0.0149635417919413 8219 127 73 0.574803149606299 0.00888185910694732
TF TF:M00638 Factor: HNF4alpha; motif: VTGAACTTTGMMB 0.0164407944523267 2814 95 27 0.284210526315789 0.00959488272921109
TF TF:M00280 Factor: RFX1; motif: NNGTNRCNWRGYAACNN 0.0165285011699779 6402 141 66 0.468085106382979 0.0103092783505155
TF TF:M03557_1 Factor: P50; motif: GGRRANTCCCNN; match class: 1 0.0165946410398556 1292 49 11 0.224489795918367 0.00851393188854489
TF TF:M00062 Factor: IRF-1; motif: SAAAAGYGAAACC 0.0167680002616873 576 142 13 0.0915492957746479 0.0225694444444444
TF TF:M07087_1 Factor: Elf-1; motif: NRANCMGGAAGTG; match class: 1 0.0167680002616873 155 113 6 0.0530973451327434 0.0387096774193548
TF TF:M11674_1 Factor: IRF-3; motif: GCNGTTTCCWGGAAACNGAAAC; match class: 1 0.0167680002616873 1663 17 7 0.411764705882353 0.0042092603728202
TF TF:M10079_1 Factor: STAT1; motif: NCCNTTTCCNGGAAANCNC; match class: 1 0.0183190683233139 1164 92 15 0.16304347826087 0.0128865979381443
TF TF:M01279_1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 1 0.0186643622487182 101 26 3 0.115384615384615 0.0297029702970297
TF TF:M02052 Factor: EHF; motif: CSCGGAARTN 0.0195745734835052 10107 121 81 0.669421487603306 0.00801424755120214
TF TF:M11360 Factor: c-MAF; motif: NTGCTGACNNNGCR 0.0197073176125551 221 30 4 0.133333333333333 0.0180995475113122
TF TF:M03793 Factor: IRF-7; motif: AARGGAAANNGAA 0.0200078505012648 1987 141 28 0.198581560283688 0.0140915953699044
TF TF:M04052 Factor: NFATc1; motif: TTTCCAYWRTGGAAA 0.0210975863811842 6663 50 29 0.58 0.00435239381659913
TF TF:M04300 Factor: Dlx-2; motif: NYAATTAN 0.0211542251175911 5422 104 45 0.432692307692308 0.0082995204721505
TF TF:M03791 Factor: GABPalpha_GABPbeta; motif: CTTCCKGY 0.0212237144571732 2969 146 38 0.26027397260274 0.0127989221960256
TF TF:M04144 Factor: TEAD3; motif: RCATTCCW 0.0232205681858628 1211 7 4 0.571428571428571 0.00330305532617671
TF TF:M08295 Factor: FOXO1A:Elf-1; motif: NAGAAAACCGAANM 0.0234053325275485 11711 74 58 0.783783783783784 0.00495260865852617
TF TF:M01808 Factor: NMYC; motif: CAYCTG 0.0235985408824252 12944 30 28 0.933333333333333 0.00216316440049444
TF TF:M11378 Factor: ESE-1; motif: ACMAGGAAGTANNNNNNNWWAWW 0.0241980758336138 3049 60 20 0.333333333333333 0.00655952771400459
TF TF:M03545_1 Factor: c-Rel; motif: NGGGAATYTCCN; match class: 1 0.0242604466135104 1011 76 12 0.157894736842105 0.0118694362017804
TF TF:M07038_1 Factor: DBP; motif: TTRCATAANN; match class: 1 0.0248675844441407 772 72 10 0.138888888888889 0.0129533678756477
TF TF:M04433 Factor: PRRX2; motif: NYAATTAN 0.0248828788197261 3153 17 9 0.529411764705882 0.00285442435775452
TF TF:M06285 Factor: ZNF124; motif: NGGTACTTGGGA 0.0271848116938045 31 101 3 0.0297029702970297 0.0967741935483871
TF TF:M03906_1 Factor: HIC2; motif: RTGCCCRNN; match class: 1 0.0275305066761372 401 70 7 0.1 0.0174563591022444
TF TF:M00225_1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 1 0.0275305066761372 1922 93 20 0.21505376344086 0.0104058272632674
TF TF:M00641_1 Factor: HSF; motif: TTCCMGARGYTTC; match class: 1 0.029114461687562 387 53 6 0.113207547169811 0.0155038759689922
TF TF:M08282 Factor: Fli-1:Prrxl1; motif: ACCGGAAGTAATTAN 0.0304480942659173 2188 146 30 0.205479452054795 0.0137111517367459
TF TF:M07042 Factor: HES-1; motif: NNCKYGTGNNN 0.0311142907727355 3966 84 30 0.357142857142857 0.0075642965204236
TF TF:M02265 Factor: NFATc2; motif: TTTTCCA 0.03175775129866 7752 30 21 0.7 0.00270897832817337
TF TF:M10027 Factor: Pax-5; motif: SCNNGGGCARCNRAGCGWGAC 0.0323805264203494 3374 102 31 0.303921568627451 0.00918790752815649
TF TF:M00054_1 Factor: NF-kappaB; motif: GGGAMTTYCC; match class: 1 0.0336888164923866 712 42 7 0.166666666666667 0.0098314606741573
TF TF:M01996 Factor: AR; motif: GNNCNNNNTGTTCTN 0.0344080139776525 3085 57 19 0.333333333333333 0.00615883306320908
TF TF:M02065_1 Factor: ER81; motif: RCCGGAARYN; match class: 1 0.0344080139776525 6749 141 67 0.475177304964539 0.00992739665135576
TF TF:M04421 Factor: OTX2; motif: NTAATCCN 0.0358814064337937 568 7 3 0.428571428571429 0.00528169014084507
TF TF:M00205_1 Factor: GR; motif: GGTACAANNTGTYCTK; match class: 1 0.0363088097279038 1482 56 12 0.214285714285714 0.00809716599190283
TF TF:M00126 Factor: GATA-1; motif: NNNNNGATANKGGN 0.0363828265591259 3887 10 7 0.7 0.00180087471057371
TF TF:M11995 Factor: NFATc4; motif: NRYGGAAANW 0.037222005764291 751 12 4 0.333333333333333 0.00532623169107856
TF TF:M11756 Factor: HNF-4alpha; motif: RRGTCCAAAGTCCAN 0.0373246368200252 3054 12 7 0.583333333333333 0.0022920759659463
TF TF:M04063_1 Factor: Pax-4; motif: SWAATWAN; match class: 1 0.0379179102901845 1003 93 13 0.139784946236559 0.0129611166500499
TF TF:M00291_1 Factor: Freac-3; motif: NNNNNGTAAATAAACA; match class: 1 0.0384090876051288 1096 29 7 0.241379310344828 0.00638686131386861
TF TF:M04145 Factor: TEAD4; motif: NRCATTCCWN 0.0386822803122282 1456 7 4 0.571428571428571 0.00274725274725275
TF TF:M07041 Factor: HDAC1; motif: KGCARGGTC 0.0418183135631788 12526 84 67 0.797619047619048 0.00534887434136995
TF TF:M01066 Factor: Blimp-1; motif: NRGRAAGKGAAAGKRN 0.0418183135631788 411 75 7 0.0933333333333333 0.0170316301703163
TF TF:M00457_1 Factor: STAT5A; motif: NAWTTCYNGGAANYN; match class: 1 0.0429659413543787 1589 92 17 0.184782608695652 0.0106985525487728
TF TF:M08575 Factor: GCMa:C/EBPbeta; motif: ATGCGGGTNNRTTGCGCAAY 0.0429659413543787 7026 12 10 0.833333333333333 0.00142328494164532
TF TF:M01660 Factor: GABP-alpha; motif: CTTCCK 0.043198960227347 11116 127 89 0.700787401574803 0.00800647715005398
TF TF:M10724 Factor: HOXD8; motif: GYMATTAN 0.043198960227347 2848 107 28 0.261682242990654 0.0098314606741573
TF TF:M11000 Factor: LIM-1; motif: NYAATTAN 0.043198960227347 5830 104 46 0.442307692307692 0.00789022298456261
TF TF:M09626 Factor: HNF-4alpha; motif: NRGNNCAAAGTYCA 0.043198960227347 1925 77 17 0.220779220779221 0.00883116883116883
TF TF:M08888_1 Factor: MAFB; motif: NTCAGCN; match class: 1 0.043198960227347 3375 66 22 0.333333333333333 0.00651851851851852
TF TF:M09959_1 Factor: IRF-4; motif: NAANGRGGAASTGAAASN; match class: 1 0.043198960227347 395 39 5 0.128205128205128 0.0126582278481013
TF TF:M00459_1 Factor: STAT5B; motif: NAWTTCYNGGAAWTN; match class: 1 0.0434785723702781 1896 92 19 0.206521739130435 0.0100210970464135
TF TF:M09664_1 Factor: STAT3; motif: NTTCCYGGAAN; match class: 1 0.0439187481207322 1875 29 9 0.310344827586207 0.0048
TF TF:M07229 Factor: STAT3; motif: NTTCYKGGAAN 0.0439187481207322 3717 76 26 0.342105263157895 0.00699488835082055
TF TF:M00346 Factor: GATA-1; motif: NCWGATAACA 0.0472218576925295 4376 17 10 0.588235294117647 0.00228519195612431
TF TF:M02015 Factor: HNF-3gamma; motif: TGTTTRYT 0.0472884599183515 2809 74 21 0.283783783783784 0.00747597009611962
TF TF:M04610 Factor: CDP; motif: NNNNWGWYMAATR 0.0474103229955565 4564 14 9 0.642857142857143 0.00197195442594216
TF TF:M08507 Factor: HOXD12:HOXA3; motif: NTAATKGNTMATAAAN 0.0475984664152409 840 29 6 0.206896551724138 0.00714285714285714
TF TF:M07228 Factor: STAT1; motif: NTTCYRGGAAA 0.0477671448653272 1919 92 19 0.206521739130435 0.0099009900990099
TF TF:M09904 Factor: Elk-1; motif: RCCGGAAGTGN 0.048649093151017 8164 146 79 0.541095890410959 0.0096766291033807
TF TF:M08453 Factor: ERF:SREBP-2; motif: NSCGGAARTCACGTGAT 0.048649093151017 10112 10 10 1 0.000988924050632911
TF TF:M08302 Factor: FOXO1A:Net; motif: RWMAACAGGAAGTN 0.0493518711377891 9303 147 88 0.598639455782313 0.00945931419972052
TF TF:M03966_1 Factor: ELF1; motif: AACCCGGAAGTR; match class: 1 0.0493518711377891 1577 146 23 0.157534246575342 0.0145846544071021
TF TF:M11398 Factor: Fli-1; motif: NACMGGAARTN 0.0493518711377891 2389 110 25 0.227272727272727 0.0104646295521139
WP WP:WP4197 The human immune response to tuberculosis 5.76919556521937e-11 23 113 10 0.0884955752212389 0.434782608695652
WP WP:WP619 Type II interferon signaling (IFNG) 2.49548167401194e-10 37 113 11 0.0973451327433628 0.297297297297297
WP WP:WP4880 Host-pathogen interaction of human corona viruses - Interferon induction 1.37375644206746e-09 33 113 10 0.0884955752212389 0.303030303030303
WP WP:WP4868 Type I Interferon Induction and Signaling During SARS-CoV-2 Infection 2.57482751868108e-07 29 113 8 0.0707964601769911 0.275862068965517
WP WP:WP4705 Pathways of nucleic acid metabolism and innate immune sensing 6.63914407950969e-06 16 68 5 0.0735294117647059 0.3125
WP WP:WP4341 Non-genomic actions of 1,25 dihydroxyvitamin D3 0.000396097105802199 70 17 4 0.235294117647059 0.0571428571428571
WP WP:WP5039 SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response 0.000619545399590357 68 99 7 0.0707070707070707 0.102941176470588
WP WP:WP4912 SARS coronavirus and innate immunity 0.00172113884401098 31 113 5 0.0442477876106195 0.161290322580645
WP WP:WP4877 Host-pathogen interaction of human corona viruses - MAPK signaling 0.00193663834769144 36 53 4 0.0754716981132075 0.111111111111111
WP WP:WP4217 Ebola Virus Pathway on Host 0.00429783391888345 130 19 4 0.210526315789474 0.0307692307692308
WP WP:WP2113 Type III interferon signaling 0.00534600984901692 10 113 3 0.0265486725663717 0.3
WP WP:WP3865 Novel intracellular components of RIG-I-like receptor (RLR) pathway 0.0151063211392126 61 100 5 0.05 0.0819672131147541
WP WP:WP4655 Cytosolic DNA-sensing pathway 0.0182697757799485 74 24 3 0.125 0.0405405405405405
WP WP:WP5038 SARS-CoV-2 mitochondrial interactions 0.0310779034074406 32 68 3 0.0441176470588235 0.09375

pEpiTp21 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp21
Possible regulators of activation of pEpiTp21 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.