pEpiTp29 program activity among Epithelial cells

Activation of pEpiTp29
pEpiTp29 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp29 by different cell subtypes
pEpiTp29 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp29 top program genes

Top genes of pEpiTp29 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp29 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp29
pEpiTp29 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0044281 small molecule metabolic process 0.00344646024645828 1921 141 35 0.24822695035461 0.0182196772514315
GO:BP GO:1900371 regulation of purine nucleotide biosynthetic process 0.00719190174213322 42 140 5 0.0357142857142857 0.119047619047619
GO:BP GO:0034308 primary alcohol metabolic process 0.00719190174213322 95 141 7 0.049645390070922 0.0736842105263158
GO:BP GO:0015701 bicarbonate transport 0.00719190174213322 42 108 5 0.0462962962962963 0.119047619047619
GO:BP GO:0019637 organophosphate metabolic process 0.00719190174213322 1041 141 22 0.156028368794326 0.021133525456292
GO:BP GO:0030808 regulation of nucleotide biosynthetic process 0.00719190174213322 43 140 5 0.0357142857142857 0.116279069767442
GO:BP GO:0007586 digestion 0.00719190174213322 141 42 5 0.119047619047619 0.0354609929078014
GO:BP GO:0006885 regulation of pH 0.00719190174213322 103 132 7 0.053030303030303 0.0679611650485437
GO:BP GO:0051453 regulation of intracellular pH 0.00747919117635162 89 116 6 0.0517241379310345 0.0674157303370786
GO:BP GO:0110096 cellular response to aldehyde 0.00757055256681019 13 83 3 0.036144578313253 0.230769230769231
GO:BP GO:0055067 monovalent inorganic cation homeostasis 0.00757700753528755 165 132 8 0.0606060606060606 0.0484848484848485
GO:BP GO:0030641 regulation of cellular pH 0.00813223290921841 95 116 6 0.0517241379310345 0.0631578947368421
GO:BP GO:1902563 regulation of neutrophil activation 0.0085865445554559 12 103 3 0.029126213592233 0.25
GO:BP GO:0006140 regulation of nucleotide metabolic process 0.00905018784075256 121 140 7 0.05 0.0578512396694215
GO:BP GO:1901135 carbohydrate derivative metabolic process 0.0117118655186508 1145 139 22 0.158273381294964 0.0192139737991266
GO:BP GO:0044242 cellular lipid catabolic process 0.0146645520577047 232 141 9 0.0638297872340425 0.0387931034482759
GO:BP GO:0031282 regulation of guanylate cyclase activity 0.0146645520577047 12 140 3 0.0214285714285714 0.25
GO:BP GO:0006730 one-carbon metabolic process 0.0146645520577047 39 111 4 0.036036036036036 0.102564102564103
GO:BP GO:0016042 lipid catabolic process 0.0146645520577047 349 141 11 0.0780141843971631 0.0315186246418338
GO:BP GO:0071827 plasma lipoprotein particle organization 0.0151820722500965 52 85 4 0.0470588235294118 0.0769230769230769
GO:BP GO:0030004 cellular monovalent inorganic cation homeostasis 0.0156382357210134 118 116 6 0.0517241379310345 0.0508474576271186
GO:BP GO:0044283 small molecule biosynthetic process 0.0157595125039194 704 99 13 0.131313131313131 0.0184659090909091
GO:BP GO:0016266 O-glycan processing 0.0161476379778806 58 31 3 0.0967741935483871 0.0517241379310345
GO:BP GO:0071825 protein-lipid complex subunit organization 0.0162445960110886 56 85 4 0.0470588235294118 0.0714285714285714
GO:BP GO:0097006 regulation of plasma lipoprotein particle levels 0.0167341667614907 107 85 5 0.0588235294117647 0.0467289719626168
GO:BP GO:0042445 hormone metabolic process 0.0190231173209838 228 94 7 0.074468085106383 0.0307017543859649
GO:BP GO:0007588 excretion 0.0190231173209838 62 83 4 0.0481927710843374 0.0645161290322581
GO:BP GO:0042742 defense response to bacterium 0.0201731809739075 349 16 4 0.25 0.0114613180515759
GO:BP GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 0.0211502082180666 23 94 3 0.0319148936170213 0.130434782608696
GO:BP GO:1900542 regulation of purine nucleotide metabolic process 0.0267898032580014 119 140 6 0.0428571428571429 0.0504201680672269
GO:BP GO:0034369 plasma lipoprotein particle remodeling 0.0267898032580014 33 74 3 0.0405405405405405 0.0909090909090909
GO:BP GO:0010743 regulation of macrophage derived foam cell differentiation 0.0267898032580014 32 74 3 0.0405405405405405 0.09375
GO:BP GO:0034368 protein-lipid complex remodeling 0.0267898032580014 33 74 3 0.0405405405405405 0.0909090909090909
GO:BP GO:0006753 nucleoside phosphate metabolic process 0.029110357063998 555 140 13 0.0928571428571429 0.0234234234234234
GO:BP GO:0055086 nucleobase-containing small molecule metabolic process 0.029110357063998 629 140 14 0.1 0.0222575516693164
GO:BP GO:0034367 protein-containing complex remodeling 0.0294915530301833 35 74 3 0.0405405405405405 0.0857142857142857
GO:BP GO:0010742 macrophage derived foam cell differentiation 0.0299177793322987 37 74 3 0.0405405405405405 0.0810810810810811
GO:BP GO:0045981 positive regulation of nucleotide metabolic process 0.0299177793322987 46 139 4 0.0287769784172662 0.0869565217391304
GO:BP GO:1900544 positive regulation of purine nucleotide metabolic process 0.0299177793322987 46 139 4 0.0287769784172662 0.0869565217391304
GO:BP GO:0009617 response to bacterium 0.0299177793322987 743 17 5 0.294117647058824 0.00672947510094213
GO:BP GO:0090077 foam cell differentiation 0.0299177793322987 37 74 3 0.0405405405405405 0.0810810810810811
GO:BP GO:0065008 regulation of biological quality 0.0310930617309498 4131 125 45 0.36 0.0108932461873638
GO:BP GO:0030810 positive regulation of nucleotide biosynthetic process 0.0310930617309498 22 139 3 0.0215827338129496 0.136363636363636
GO:BP GO:0044282 small molecule catabolic process 0.0310930617309498 439 98 9 0.0918367346938776 0.020501138952164
GO:BP GO:1900373 positive regulation of purine nucleotide biosynthetic process 0.0310930617309498 22 139 3 0.0215827338129496 0.136363636363636
GO:BP GO:0031349 positive regulation of defense response 0.0310930617309498 362 20 4 0.2 0.0110497237569061
GO:BP GO:0009395 phospholipid catabolic process 0.0320015122648522 51 141 4 0.0283687943262411 0.0784313725490196
GO:BP GO:0015711 organic anion transport 0.0320015122648522 386 69 7 0.101449275362319 0.0181347150259067
GO:BP GO:0006493 protein O-linked glycosylation 0.0320230858573057 102 31 3 0.0967741935483871 0.0294117647058824
GO:BP GO:0046470 phosphatidylcholine metabolic process 0.0320230858573057 90 141 5 0.0354609929078014 0.0555555555555556
GO:BP GO:0022600 digestive system process 0.0320230858573057 102 31 3 0.0967741935483871 0.0294117647058824
GO:BP GO:0006163 purine nucleotide metabolic process 0.0342021593690545 450 140 11 0.0785714285714286 0.0244444444444444
GO:BP GO:0042119 neutrophil activation 0.0347572027523855 498 16 4 0.25 0.00803212851405622
GO:BP GO:0006575 cellular modified amino acid metabolic process 0.0347572027523855 199 99 6 0.0606060606060606 0.0301507537688442
GO:BP GO:0036230 granulocyte activation 0.0349040758876802 504 16 4 0.25 0.00793650793650794
GO:BP GO:0034754 cellular hormone metabolic process 0.0349040758876802 140 94 5 0.0531914893617021 0.0357142857142857
GO:BP GO:0035306 positive regulation of dephosphorylation 0.0407287102407914 58 139 4 0.0287769784172662 0.0689655172413793
GO:BP GO:0046337 phosphatidylethanolamine metabolic process 0.0407287102407914 32 113 3 0.0265486725663717 0.09375
GO:BP GO:0009117 nucleotide metabolic process 0.0410621892998317 544 140 12 0.0857142857142857 0.0220588235294118
GO:BP GO:0051707 response to other organism 0.0416315475781101 1592 20 7 0.35 0.00439698492462312
GO:BP GO:0043207 response to external biotic stimulus 0.0416315475781101 1594 20 7 0.35 0.00439146800501882
GO:BP GO:0072521 purine-containing compound metabolic process 0.0416315475781101 473 140 11 0.0785714285714286 0.0232558139534884
GO:BP GO:0009607 response to biotic stimulus 0.0447210182608689 1626 20 7 0.35 0.0043050430504305
GO:BP GO:0046434 organophosphate catabolic process 0.0490158388219943 157 141 6 0.0425531914893617 0.0382165605095541
GO:BP GO:0046903 secretion 0.0490158388219943 1501 117 20 0.170940170940171 0.0133244503664224
GO:CC GO:0070062 extracellular exosome 1.00855288293286e-09 2176 116 42 0.362068965517241 0.0193014705882353
GO:CC GO:1903561 extracellular vesicle 1.22040863634323e-09 2261 116 42 0.362068965517241 0.0185758513931889
GO:CC GO:0043230 extracellular organelle 1.22040863634323e-09 2263 116 42 0.362068965517241 0.0185594343791427
GO:CC GO:0005615 extracellular space 1.406437252222e-07 3594 103 46 0.446601941747573 0.0127991096271564
GO:CC GO:0005886 plasma membrane 1.406437252222e-07 5681 30 25 0.833333333333333 0.00440063369125154
GO:CC GO:0031982 vesicle 2.8131183752372e-07 4055 87 43 0.494252873563218 0.0106041923551171
GO:CC GO:0005576 extracellular region 2.8131183752372e-07 4567 76 42 0.552631578947368 0.00919640902123933
GO:CC GO:0005903 brush border 2.8131183752372e-07 107 140 10 0.0714285714285714 0.0934579439252336
GO:CC GO:0045177 apical part of cell 3.74814159502497e-07 431 29 9 0.310344827586207 0.0208816705336427
GO:CC GO:0071944 cell periphery 4.64622611727517e-07 6169 30 25 0.833333333333333 0.00405252066785541
GO:CC GO:0016324 apical plasma membrane 1.4868418232998e-06 361 29 8 0.275862068965517 0.0221606648199446
GO:CC GO:0098862 cluster of actin-based cell projections 9.78037552340494e-06 162 140 10 0.0714285714285714 0.0617283950617284
GO:CC GO:0031526 brush border membrane 3.65745167932317e-05 59 27 4 0.148148148148148 0.0677966101694915
GO:CC GO:0016020 membrane 5.08934109691105e-05 9838 113 83 0.734513274336283 0.00843667412075625
GO:CC GO:0098590 plasma membrane region 5.24743427588321e-05 1240 71 17 0.23943661971831 0.0137096774193548
GO:CC GO:0031224 intrinsic component of membrane 0.000121198185939535 5868 141 69 0.48936170212766 0.011758691206544
GO:CC GO:0016021 integral component of membrane 0.000420803470429351 5711 141 66 0.468085106382979 0.0115566450709158
GO:CC GO:0031226 intrinsic component of plasma membrane 0.00268972603665016 1726 29 10 0.344827586206897 0.00579374275782155
GO:CC GO:0005773 vacuole 0.00618827514930929 810 76 11 0.144736842105263 0.0135802469135802
GO:CC GO:0005923 bicellular tight junction 0.00743750855830967 123 102 5 0.0490196078431373 0.040650406504065
GO:CC GO:0030141 secretory granule 0.00743750855830967 851 16 5 0.3125 0.00587544065804935
GO:CC GO:0005887 integral component of plasma membrane 0.00743750855830967 1645 29 9 0.310344827586207 0.00547112462006079
GO:CC GO:0000323 lytic vacuole 0.00743750855830967 712 76 10 0.131578947368421 0.0140449438202247
GO:CC GO:0005764 lysosome 0.00743750855830967 712 76 10 0.131578947368421 0.0140449438202247
GO:CC GO:0043296 apical junction complex 0.00914510502928089 145 140 6 0.0428571428571429 0.0413793103448276
GO:CC GO:0070160 tight junction 0.00914510502928089 131 102 5 0.0490196078431373 0.0381679389312977
GO:CC GO:0005905 clathrin-coated pit 0.0107371697309447 71 51 3 0.0588235294117647 0.0422535211267606
GO:CC GO:0016323 basolateral plasma membrane 0.0107371697309447 222 64 5 0.078125 0.0225225225225225
GO:CC GO:0099503 secretory vesicle 0.0133430515735247 1020 16 5 0.3125 0.00490196078431373
GO:CC GO:0005775 vacuolar lumen 0.0139404845393703 174 130 6 0.0461538461538462 0.0344827586206897
GO:CC GO:0031253 cell projection membrane 0.0140397373884465 343 27 4 0.148148148148148 0.0116618075801749
GO:CC GO:0035578 azurophil granule lumen 0.0145616003004328 91 101 4 0.0396039603960396 0.043956043956044
GO:CC GO:0009925 basal plasma membrane 0.0146088479249577 247 64 5 0.078125 0.0202429149797571
GO:CC GO:0031983 vesicle lumen 0.0177887053919389 326 15 3 0.2 0.00920245398773006
GO:CC GO:0034774 secretory granule lumen 0.0177887053919389 320 15 3 0.2 0.009375
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0177887053919389 324 15 3 0.2 0.00925925925925926
GO:CC GO:0045178 basal part of cell 0.0177887053919389 265 64 5 0.078125 0.0188679245283019
GO:CC GO:0005794 Golgi apparatus 0.0203377477362769 1623 23 7 0.304347826086957 0.00431300061614294
GO:CC GO:0030864 cortical actin cytoskeleton 0.0218202740667162 79 138 4 0.0289855072463768 0.0506329113924051
GO:CC GO:0048471 perinuclear region of cytoplasm 0.0225948689412129 735 16 4 0.25 0.0054421768707483
GO:CC GO:0098857 membrane microdomain 0.0235309081137096 335 109 7 0.0642201834862385 0.0208955223880597
GO:CC GO:0098852 lytic vacuole membrane 0.0235309081137096 383 15 3 0.2 0.00783289817232376
GO:CC GO:0005765 lysosomal membrane 0.0235309081137096 383 15 3 0.2 0.00783289817232376
GO:CC GO:0012505 endomembrane system 0.0235309081137096 4640 31 15 0.483870967741935 0.00323275862068966
GO:CC GO:0045121 membrane raft 0.0235309081137096 335 109 7 0.0642201834862385 0.0208955223880597
GO:CC GO:0043202 lysosomal lumen 0.0298822259144509 97 130 4 0.0307692307692308 0.0412371134020619
GO:CC GO:0005774 vacuolar membrane 0.0300133624456278 441 15 3 0.2 0.00680272108843537
GO:CC GO:0009986 cell surface 0.0319725857878991 899 108 12 0.111111111111111 0.0133481646273637
GO:CC GO:0030863 cortical cytoskeleton 0.0437513444248128 107 138 4 0.0289855072463768 0.0373831775700935
GO:MF GO:0004089 carbonate dehydratase activity 0.00363500229558731 15 54 3 0.0555555555555556 0.2
GO:MF GO:0030249 guanylate cyclase regulator activity 0.00363500229558731 7 140 3 0.0214285714285714 0.428571428571429
GO:MF GO:0010851 cyclase regulator activity 0.00575226719993153 9 140 3 0.0214285714285714 0.333333333333333
GO:MF GO:0004620 phospholipase activity 0.0131053301945182 109 141 6 0.0425531914893617 0.055045871559633
GO:MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0165452987791945 125 94 5 0.0531914893617021 0.04
GO:MF GO:0016298 lipase activity 0.0174271713488108 134 141 6 0.0425531914893617 0.0447761194029851
GO:MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 0.019460121016556 137 94 5 0.0531914893617021 0.0364963503649635
GO:MF GO:0052689 carboxylic ester hydrolase activity 0.0231024218473259 146 141 6 0.0425531914893617 0.0410958904109589
GO:MF GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) 0.0231024218473259 27 136 3 0.0220588235294118 0.111111111111111
GO:MF GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) 0.0231024218473259 27 136 3 0.0220588235294118 0.111111111111111
GO:MF GO:0016836 hydro-lyase activity 0.0231024218473259 65 54 3 0.0555555555555556 0.0461538461538462
GO:MF GO:0048029 monosaccharide binding 0.0241001370503565 71 53 3 0.0566037735849057 0.0422535211267606
GO:MF GO:0016835 carbon-oxygen lyase activity 0.0305765035756782 81 54 3 0.0555555555555556 0.037037037037037
GO:MF GO:0004623 phospholipase A2 activity 0.0357868622733691 35 136 3 0.0220588235294118 0.0857142857142857
GO:MF GO:0016829 lyase activity 0.0412479505816182 203 54 4 0.0740740740740741 0.0197044334975369
KEGG KEGG:04964 Proximal tubule bicarbonate reclamation 0.0142209288821495 23 108 4 0.037037037037037 0.173913043478261
KEGG KEGG:04972 Pancreatic secretion 0.0142209288821495 102 21 4 0.19047619047619 0.0392156862745098
KEGG KEGG:00910 Nitrogen metabolism 0.0142209288821495 17 54 3 0.0555555555555556 0.176470588235294
REAC REAC:R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.00168701350875943 7 54 3 0.0555555555555556 0.428571428571429
REAC REAC:R-HSA-1475029 Reversible hydration of carbon dioxide 0.00260331360561884 12 54 3 0.0555555555555556 0.25
REAC REAC:R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.00260331360561884 11 54 3 0.0555555555555556 0.272727272727273
REAC REAC:R-HSA-1480926 O2/CO2 exchange in erythrocytes 0.00260331360561884 11 54 3 0.0555555555555556 0.272727272727273
REAC REAC:R-HSA-913709 O-linked glycosylation of mucins 0.035523203750117 61 31 3 0.0967741935483871 0.0491803278688525
TF TF:M00517 Factor: AP-1; motif: NNNTGAGTCAKCN 0.0114343533625252 5023 142 62 0.436619718309859 0.0123432211825602
TF TF:M09964 Factor: JunD; motif: NRTGAGTCAYN 0.0117658201038011 5047 141 61 0.432624113475177 0.0120863879532395
TF TF:M09615 Factor: Fra-1; motif: NRTGACTCATN 0.0150171175790934 4111 141 52 0.368794326241135 0.0126489905132571
TF TF:M04458_1 Factor: ESRRA; motif: CAAGGTCANNYSAAGGTCA; match class: 1 0.0150171175790934 4477 84 37 0.44047619047619 0.00826446280991736
TF TF:M09965 Factor: c-Jun; motif: NRTGAGTCAYN 0.0150171175790934 4492 141 55 0.390070921985816 0.0122439893143366
TF TF:M08933 Factor: JUND:C-FOS; motif: NNATGAGTCATNN 0.0160023957601353 4818 141 57 0.404255319148936 0.0118306351183064
TF TF:M03551 Factor: JunB; motif: TGACTCAN 0.0160023957601353 4253 141 52 0.368794326241135 0.0122266635316247
TF TF:M02280 Factor: AP1; motif: TGACTCA 0.0160023957601353 4255 141 52 0.368794326241135 0.0122209165687427
TF TF:M09923 Factor: Fra-2; motif: NNRTGAGTCAYN 0.0160023957601353 4336 141 53 0.375886524822695 0.0122232472324723
TF TF:M00199_1 Factor: AP-1; motif: NTGASTCAG; match class: 1 0.0160023957601353 4265 141 52 0.368794326241135 0.0121922626025791
TF TF:M09616 Factor: Fra-2; motif: RTGACTCANNN 0.0168448932940667 4760 141 56 0.397163120567376 0.0117647058823529
TF TF:M00924 Factor: AP-1; motif: TGACTCANNSKN 0.0168448932940667 2801 133 37 0.278195488721804 0.0132095680114245
TF TF:M07459 Factor: HSF1; motif: GAANNTTCTNGN 0.0191221090812772 3422 43 19 0.441860465116279 0.00555230859146698
TF TF:M03870 Factor: Fra-2; motif: TGASTCANCN 0.0207126539893303 3634 142 46 0.323943661971831 0.0126582278481013
TF TF:M04926 Factor: REST; motif: AAGGTGCT 0.0214300898997992 6325 73 40 0.547945205479452 0.00632411067193676
TF TF:M00199 Factor: AP-1; motif: NTGASTCAG 0.0217478450332657 4833 142 56 0.394366197183099 0.0115870060004138
TF TF:M11774_1 Factor: RXR-alpha; motif: RRGGTCAAAGGTCAN; match class: 1 0.0217478450332657 1000 124 18 0.145161290322581 0.018
TF TF:M08938 Factor: C-JUN:FRA-1; motif: NNATGACTCATNN 0.0230167576024591 3714 141 46 0.326241134751773 0.0123855681206247
TF TF:M03869 Factor: Fra-1; motif: TGACTCAN 0.0262340281313114 3514 141 44 0.312056737588652 0.012521343198634
TF TF:M09922 Factor: Fra-1; motif: NNNTGAGTCAYN 0.0269728581777573 4573 141 53 0.375886524822695 0.0115897660179313
TF TF:M04468 Factor: HNF4A; motif: RRGTCCAAAGGTCAN 0.0269728581777573 1186 139 21 0.151079136690647 0.0177065767284992
TF TF:M01835_1 Factor: GKLF; motif: CCTCCYN; match class: 1 0.0328077695557738 10142 44 35 0.795454545454545 0.00345099585880497
TF TF:M07296 Factor: MAF; motif: GCTGAGTCAN 0.0350695597231354 5670 126 56 0.444444444444444 0.00987654320987654
TF TF:M02021 Factor: LXRbeta:RXRalpha; motif: NGAGGTCACKRNYGG 0.0443533399316314 506 5 3 0.6 0.00592885375494071
TF TF:M00037 Factor: NF-E2; motif: TGCTGAGTCAY 0.0459563290686362 6629 123 61 0.495934959349593 0.0092019912505657
TF TF:M07292_1 Factor: GLI; motif: NTGGGTGGTN; match class: 1 0.0470745323619817 1193 3 3 1 0.00251466890192791
TF TF:M09998 Factor: NeuroD-2; motif: RRCAGATGG 0.0470745323619817 321 126 9 0.0714285714285714 0.0280373831775701
TF TF:M11732 Factor: PXR; motif: NYGAACYNNNYGMMCTN 0.0470745323619817 2795 130 34 0.261538461538462 0.0121645796064401
TF TF:M09999 Factor: Nrf2; motif: WWNTGCTGAGTCAT 0.0470745323619817 2658 141 35 0.24822695035461 0.0131677953348382
TF TF:M08019 Factor: RARA; motif: AGGTCANNYAAAGGTCA 0.0470745323619817 5530 37 21 0.567567567567568 0.00379746835443038
TF TF:M09920_1 Factor: Fli-1; motif: NNRGGMAGGAAGGRRRGR; match class: 1 0.0470745323619817 3358 41 17 0.414634146341463 0.00506253722453842
TF TF:M09776 Factor: NEUROD1; motif: NNACAGATGGNNN 0.0490617994826192 919 126 16 0.126984126984127 0.0174102285092492
TF TF:M07611 Factor: p54NRB; motif: GRNNNMGGATGRMNNCGGA 0.0490617994826192 6991 8 8 1 0.00114432842225719
TF TF:M08369_1 Factor: HOXD12:PEA3; motif: RCCGGAAGTAATAAAM; match class: 1 0.0491236586597862 657 51 8 0.156862745098039 0.0121765601217656
TF TF:M07345 Factor: ZNF515; motif: SCTGCTGK 0.0492305449076473 2527 4 4 1 0.00158290462999604

pEpiTp29 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp29
Possible regulators of activation of pEpiTp29 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.