pEpi05 program activity among Epithelial cells

Activation of pEpi05
pEpi05 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi05 by different cell subtypes
pEpi05 gene program activation among cells of different subtypes (Epithelial cells).

pEpi05 top program genes

Top genes of pEpi05 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi05 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi05
pEpi05 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0030111 regulation of Wnt signaling pathway 1.33582514185758e-05 376 61 12 0.19672131147541 0.0319148936170213
GO:BP GO:0023051 regulation of signaling 8.232943066013e-05 3578 82 38 0.463414634146341 0.0106204583566238
GO:BP GO:0003401 axis elongation 8.53424176165877e-05 30 133 6 0.0451127819548872 0.2
GO:BP GO:0198738 cell-cell signaling by wnt 8.53424176165877e-05 531 61 12 0.19672131147541 0.0225988700564972
GO:BP GO:0016055 Wnt signaling pathway 8.53424176165877e-05 529 61 12 0.19672131147541 0.0226843100189036
GO:BP GO:0009653 anatomical structure morphogenesis 8.53424176165877e-05 2797 142 47 0.330985915492958 0.0168037182695745
GO:BP GO:0010646 regulation of cell communication 8.53424176165877e-05 3543 82 37 0.451219512195122 0.0104431272932543
GO:BP GO:0007166 cell surface receptor signaling pathway 0.000119951227424316 3210 64 29 0.453125 0.00903426791277259
GO:BP GO:0009966 regulation of signal transduction 0.000119951227424316 3165 82 34 0.414634146341463 0.0107424960505529
GO:BP GO:0060828 regulation of canonical Wnt signaling pathway 0.000228663823321161 298 61 9 0.147540983606557 0.0302013422818792
GO:BP GO:0070542 response to fatty acid 0.000303840212465364 69 139 7 0.0503597122302158 0.101449275362319
GO:BP GO:0071495 cellular response to endogenous stimulus 0.000303840212465364 1422 110 25 0.227272727272727 0.0175808720112518
GO:BP GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 0.00031286018488523 636 61 12 0.19672131147541 0.0188679245283019
GO:BP GO:0001501 skeletal system development 0.000313758639423443 504 136 16 0.117647058823529 0.0317460317460317
GO:BP GO:0009968 negative regulation of signal transduction 0.000316665266321834 1364 80 20 0.25 0.0146627565982405
GO:BP GO:0009719 response to endogenous stimulus 0.000422871871918929 1683 110 27 0.245454545454545 0.0160427807486631
GO:BP GO:0030178 negative regulation of Wnt signaling pathway 0.000422871871918929 218 94 9 0.0957446808510638 0.0412844036697248
GO:BP GO:0060070 canonical Wnt signaling pathway 0.000427014489704629 345 61 9 0.147540983606557 0.0260869565217391
GO:BP GO:0001655 urogenital system development 0.000480521465389317 337 142 13 0.0915492957746479 0.0385756676557863
GO:BP GO:0009887 animal organ morphogenesis 0.000536414767966697 1073 142 24 0.169014084507042 0.0223671947809879
GO:BP GO:0048729 tissue morphogenesis 0.000599928551814423 667 140 18 0.128571428571429 0.0269865067466267
GO:BP GO:0048731 system development 0.000599928551814423 5052 61 34 0.557377049180328 0.00673000791765637
GO:BP GO:0023057 negative regulation of signaling 0.000599928551814423 1471 80 20 0.25 0.0135961930659415
GO:BP GO:0010648 negative regulation of cell communication 0.000599928551814423 1468 80 20 0.25 0.0136239782016349
GO:BP GO:0072001 renal system development 0.000599928551814423 302 140 12 0.0857142857142857 0.0397350993377483
GO:BP GO:0010033 response to organic substance 0.000599928551814423 3412 110 41 0.372727272727273 0.0120164126611958
GO:BP GO:0048513 animal organ development 0.000750568148277424 3672 61 28 0.459016393442623 0.00762527233115468
GO:BP GO:0001649 osteoblast differentiation 0.00089355177129308 232 103 9 0.087378640776699 0.0387931034482759
GO:BP GO:0071310 cellular response to organic substance 0.00116228510738471 2776 110 35 0.318181818181818 0.0126080691642651
GO:BP GO:0030198 extracellular matrix organization 0.00116228510738471 401 80 10 0.125 0.0249376558603491
GO:BP GO:0043062 extracellular structure organization 0.00116228510738471 402 80 10 0.125 0.0248756218905473
GO:BP GO:0060602 branch elongation of an epithelium 0.00116228510738471 19 133 4 0.0300751879699248 0.210526315789474
GO:BP GO:0048585 negative regulation of response to stimulus 0.00116228510738471 1733 61 18 0.295081967213115 0.0103866128101558
GO:BP GO:0045229 external encapsulating structure organization 0.00117117065981718 404 80 10 0.125 0.0247524752475248
GO:BP GO:0060449 bud elongation involved in lung branching 0.0013146666560904 7 133 3 0.0225563909774436 0.428571428571429
GO:BP GO:0032502 developmental process 0.0013146666560904 6628 142 77 0.542253521126761 0.0116173808086904
GO:BP GO:0050793 regulation of developmental process 0.00136422357683998 2605 142 40 0.28169014084507 0.0153550863723608
GO:BP GO:0048856 anatomical structure development 0.00136422357683998 6106 61 37 0.60655737704918 0.00605961349492303
GO:BP GO:0048583 regulation of response to stimulus 0.00136831468315723 4278 82 37 0.451219512195122 0.00864890135577373
GO:BP GO:0001763 morphogenesis of a branching structure 0.00140021595760904 195 135 9 0.0666666666666667 0.0461538461538462
GO:BP GO:0007267 cell-cell signaling 0.00149442554108369 1722 64 18 0.28125 0.0104529616724739
GO:BP GO:0002009 morphogenesis of an epithelium 0.00149442554108369 560 135 15 0.111111111111111 0.0267857142857143
GO:BP GO:0001503 ossification 0.00149442554108369 417 82 10 0.121951219512195 0.0239808153477218
GO:BP GO:0048598 embryonic morphogenesis 0.00149442554108369 595 142 16 0.112676056338028 0.026890756302521
GO:BP GO:0051093 negative regulation of developmental process 0.00149442554108369 977 61 13 0.213114754098361 0.0133060388945752
GO:BP GO:0043616 keratinocyte proliferation 0.00162204411659282 50 59 4 0.0677966101694915 0.08
GO:BP GO:0008283 cell population proliferation 0.00164738613575018 2054 103 27 0.262135922330097 0.0131450827653359
GO:BP GO:0007275 multicellular organism development 0.00211116539973651 5613 136 65 0.477941176470588 0.0115802601104579
GO:BP GO:0044087 regulation of cellular component biogenesis 0.00216086747130152 990 142 21 0.147887323943662 0.0212121212121212
GO:BP GO:0009952 anterior/posterior pattern specification 0.00221659003029821 211 136 9 0.0661764705882353 0.042654028436019
GO:BP GO:0048568 embryonic organ development 0.0025241575385016 432 142 13 0.0915492957746479 0.0300925925925926
GO:BP GO:0051085 chaperone cofactor-dependent protein refolding 0.0025241575385016 31 38 3 0.0789473684210526 0.0967741935483871
GO:BP GO:0009888 tissue development 0.00254617492399508 2107 61 19 0.311475409836066 0.00901756051257712
GO:BP GO:0030857 negative regulation of epithelial cell differentiation 0.00254617492399508 52 133 5 0.037593984962406 0.0961538461538462
GO:BP GO:0007154 cell communication 0.00254617492399508 6829 84 50 0.595238095238095 0.00732171621027969
GO:BP GO:0042127 regulation of cell population proliferation 0.0028365466640597 1774 103 24 0.233009708737864 0.0135287485907554
GO:BP GO:0035265 organ growth 0.00285628134295612 182 128 8 0.0625 0.043956043956044
GO:BP GO:0003002 regionalization 0.00304941169128824 338 136 11 0.0808823529411765 0.0325443786982249
GO:BP GO:0051084 'de novo' posttranslational protein folding 0.00339323890744572 36 38 3 0.0789473684210526 0.0833333333333333
GO:BP GO:0060441 epithelial tube branching involved in lung morphogenesis 0.00339323890744572 29 133 4 0.0300751879699248 0.137931034482759
GO:BP GO:0009790 embryo development 0.00339323890744572 1035 142 21 0.147887323943662 0.0202898550724638
GO:BP GO:0071363 cellular response to growth factor stimulus 0.00365859463435311 731 103 14 0.135922330097087 0.0191518467852257
GO:BP GO:0045667 regulation of osteoblast differentiation 0.00365859463435311 135 135 7 0.0518518518518519 0.0518518518518519
GO:BP GO:0072164 mesonephric tubule development 0.00365859463435311 93 135 6 0.0444444444444444 0.0645161290322581
GO:BP GO:2000027 regulation of animal organ morphogenesis 0.00365859463435311 184 134 8 0.0597014925373134 0.0434782608695652
GO:BP GO:0072163 mesonephric epithelium development 0.00365859463435311 93 135 6 0.0444444444444444 0.0645161290322581
GO:BP GO:0001657 ureteric bud development 0.00365859463435311 92 135 6 0.0444444444444444 0.0652173913043478
GO:BP GO:0009792 embryo development ending in birth or egg hatching 0.00373128001755363 635 134 15 0.111940298507463 0.0236220472440945
GO:BP GO:0009967 positive regulation of signal transduction 0.00373128001755363 1598 82 19 0.231707317073171 0.0118898623279099
GO:BP GO:0072073 kidney epithelium development 0.00373128001755363 137 135 7 0.0518518518518519 0.0510948905109489
GO:BP GO:0030903 notochord development 0.00373128001755363 19 80 3 0.0375 0.157894736842105
GO:BP GO:0072089 stem cell proliferation 0.00373128001755363 68 60 4 0.0666666666666667 0.0588235294117647
GO:BP GO:0061326 renal tubule development 0.00373128001755363 95 135 6 0.0444444444444444 0.0631578947368421
GO:BP GO:0006458 'de novo' protein folding 0.00379688219309173 40 38 3 0.0789473684210526 0.075
GO:BP GO:0048589 developmental growth 0.00399078492571218 649 133 15 0.112781954887218 0.0231124807395994
GO:BP GO:0001823 mesonephros development 0.00402791792028068 97 135 6 0.0444444444444444 0.0618556701030928
GO:BP GO:0023052 signaling 0.0040508926262031 6810 84 49 0.583333333333333 0.00719530102790015
GO:BP GO:0001822 kidney development 0.00428314269547867 293 140 10 0.0714285714285714 0.0341296928327645
GO:BP GO:0010647 positive regulation of cell communication 0.00435140046568268 1777 82 20 0.24390243902439 0.0112549240292628
GO:BP GO:0070848 response to growth factor 0.00435140046568268 759 103 14 0.135922330097087 0.0184453227931489
GO:BP GO:0045596 negative regulation of cell differentiation 0.00437810387407723 697 61 10 0.163934426229508 0.0143472022955524
GO:BP GO:0023056 positive regulation of signaling 0.00437810387407723 1782 82 20 0.24390243902439 0.0112233445566779
GO:BP GO:0048562 embryonic organ morphogenesis 0.00440841608994292 292 142 10 0.0704225352112676 0.0342465753424658
GO:BP GO:0048518 positive regulation of biological process 0.00444034699439448 6363 44 28 0.636363636363636 0.0044004400440044
GO:BP GO:0070887 cellular response to chemical stimulus 0.00444034699439448 3393 82 30 0.365853658536585 0.00884173297966401
GO:BP GO:0042472 inner ear morphogenesis 0.00459216181023181 97 142 6 0.0422535211267606 0.0618556701030928
GO:BP GO:0002062 chondrocyte differentiation 0.00459216181023181 108 80 5 0.0625 0.0462962962962963
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 0.00499813839266023 901 135 18 0.133333333333333 0.0199778024417314
GO:BP GO:0048754 branching morphogenesis of an epithelial tube 0.00536301900265419 151 135 7 0.0518518518518519 0.0463576158940397
GO:BP GO:0048584 positive regulation of response to stimulus 0.00588000522917369 2344 128 32 0.25 0.0136518771331058
GO:BP GO:0043254 regulation of protein-containing complex assembly 0.00644091219036781 460 135 12 0.0888888888888889 0.0260869565217391
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.00644091219036781 1042 80 14 0.175 0.0134357005758157
GO:BP GO:0060562 epithelial tube morphogenesis 0.00657918450764291 329 135 10 0.0740740740740741 0.0303951367781155
GO:BP GO:0090090 negative regulation of canonical Wnt signaling pathway 0.00657918450764291 187 80 6 0.075 0.0320855614973262
GO:BP GO:0051716 cellular response to stimulus 0.00673133499553247 7781 94 58 0.617021276595745 0.00745405474874695
GO:BP GO:0090303 positive regulation of wound healing 0.00673133499553247 60 86 4 0.0465116279069767 0.0666666666666667
GO:BP GO:0043009 chordate embryonic development 0.00674461584686013 616 134 14 0.104477611940299 0.0227272727272727
GO:BP GO:0010288 response to lead ion 0.00674461584686013 24 86 3 0.0348837209302326 0.125
GO:BP GO:0007219 Notch signaling pathway 0.00761677041129988 193 81 6 0.0740740740740741 0.0310880829015544
GO:BP GO:0050896 response to stimulus 0.00761677041129988 9407 94 66 0.702127659574468 0.00701605187626236
GO:BP GO:0035295 tube development 0.0077468610804982 1146 142 21 0.147887323943662 0.0183246073298429
GO:BP GO:0061333 renal tubule morphogenesis 0.00794136881434526 75 135 5 0.037037037037037 0.0666666666666667
GO:BP GO:0040007 growth 0.00813158303320771 967 59 11 0.186440677966102 0.0113753877973113
GO:BP GO:0048523 negative regulation of cellular process 0.00815500218656825 5139 62 31 0.5 0.00603230200428099
GO:BP GO:0051239 regulation of multicellular organismal process 0.00851595460580171 2861 61 21 0.344262295081967 0.00734009087731562
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.00851595460580171 1455 61 14 0.229508196721311 0.00962199312714777
GO:BP GO:0030155 regulation of cell adhesion 0.00851595460580171 748 4 3 0.75 0.00401069518716578
GO:BP GO:0061077 chaperone-mediated protein folding 0.00863730256960277 61 38 3 0.0789473684210526 0.0491803278688525
GO:BP GO:0048705 skeletal system morphogenesis 0.00863730256960277 226 134 8 0.0597014925373134 0.0353982300884956
GO:BP GO:0030154 cell differentiation 0.00869758135810767 4350 8 7 0.875 0.00160919540229885
GO:BP GO:0007165 signal transduction 0.00890270471154129 6309 84 45 0.535714285714286 0.00713266761768902
GO:BP GO:0042471 ear morphogenesis 0.00890270471154129 116 142 6 0.0422535211267606 0.0517241379310345
GO:BP GO:0040014 regulation of multicellular organism growth 0.00890270471154129 65 37 3 0.0810810810810811 0.0461538461538462
GO:BP GO:0048869 cellular developmental process 0.00897410755062821 4428 8 7 0.875 0.00158084914182475
GO:BP GO:0090103 cochlea morphogenesis 0.00930014348015036 23 109 3 0.0275229357798165 0.130434782608696
GO:BP GO:0060560 developmental growth involved in morphogenesis 0.0095214514305914 236 133 8 0.0601503759398496 0.0338983050847458
GO:BP GO:0072091 regulation of stem cell proliferation 0.00969289109499882 43 59 3 0.0508474576271186 0.0697674418604651
GO:BP GO:0030177 positive regulation of Wnt signaling pathway 0.00971929718177803 184 61 5 0.0819672131147541 0.0271739130434783
GO:BP GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 0.00971929718177803 129 133 6 0.0451127819548872 0.0465116279069767
GO:BP GO:0031338 regulation of vesicle fusion 0.0102413797741699 26 104 3 0.0288461538461538 0.115384615384615
GO:BP GO:0061138 morphogenesis of a branching epithelium 0.0102413797741699 181 135 7 0.0518518518518519 0.0386740331491713
GO:BP GO:0048522 positive regulation of cellular process 0.0102413797741699 5757 82 41 0.5 0.00712176480805975
GO:BP GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 0.0102413797741699 132 133 6 0.0451127819548872 0.0454545454545455
GO:BP GO:1903036 positive regulation of response to wounding 0.0102413797741699 74 86 4 0.0465116279069767 0.0540540540540541
GO:BP GO:0035239 tube morphogenesis 0.0105573300000573 950 142 18 0.126760563380282 0.0189473684210526
GO:BP GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 0.0108906274280831 88 133 5 0.037593984962406 0.0568181818181818
GO:BP GO:0001894 tissue homeostasis 0.0109333477106938 270 93 7 0.0752688172043011 0.0259259259259259
GO:BP GO:0060425 lung morphogenesis 0.0111262329221813 50 133 4 0.0300751879699248 0.08
GO:BP GO:0007389 pattern specification process 0.0114392636770772 442 136 11 0.0808823529411765 0.0248868778280543
GO:BP GO:0001942 hair follicle development 0.0123870282144395 86 80 4 0.05 0.0465116279069767
GO:BP GO:0009798 axis specification 0.0124422013460686 87 34 3 0.0882352941176471 0.0344827586206897
GO:BP GO:0048638 regulation of developmental growth 0.0128670374158531 340 37 5 0.135135135135135 0.0147058823529412
GO:BP GO:0071560 cellular response to transforming growth factor beta stimulus 0.0129920116871983 256 133 8 0.0601503759398496 0.03125
GO:BP GO:0072080 nephron tubule development 0.0131930766147598 92 135 5 0.037037037037037 0.0543478260869565
GO:BP GO:0046580 negative regulation of Ras protein signal transduction 0.0132331129362218 50 142 4 0.028169014084507 0.08
GO:BP GO:0061448 connective tissue development 0.0132341142665918 256 103 7 0.0679611650485437 0.02734375
GO:BP GO:0060021 roof of mouth development 0.0132341142665918 88 142 5 0.0352112676056338 0.0568181818181818
GO:BP GO:0022404 molting cycle process 0.0132341142665918 89 80 4 0.05 0.0449438202247191
GO:BP GO:0022405 hair cycle process 0.0132341142665918 89 80 4 0.05 0.0449438202247191
GO:BP GO:0001889 liver development 0.0132341142665918 148 128 6 0.046875 0.0405405405405405
GO:BP GO:0098773 skin epidermis development 0.0135505969188748 90 80 4 0.05 0.0444444444444444
GO:BP GO:0010638 positive regulation of organelle organization 0.0135821605142191 603 6 3 0.5 0.00497512437810945
GO:BP GO:0035264 multicellular organism growth 0.0137638702028954 140 52 4 0.0769230769230769 0.0285714285714286
GO:BP GO:0061008 hepaticobiliary system development 0.0139394180509874 151 128 6 0.046875 0.0397350993377483
GO:BP GO:0040011 locomotion 0.0139394180509874 2028 114 25 0.219298245614035 0.01232741617357
GO:BP GO:0071559 response to transforming growth factor beta 0.0139394180509874 262 133 8 0.0601503759398496 0.0305343511450382
GO:BP GO:0060993 kidney morphogenesis 0.0142869094465546 92 140 5 0.0357142857142857 0.0543478260869565
GO:BP GO:0009595 detection of biotic stimulus 0.0144635441090238 36 90 3 0.0333333333333333 0.0833333333333333
GO:BP GO:0001658 branching involved in ureteric bud morphogenesis 0.0150821851256667 56 135 4 0.0296296296296296 0.0714285714285714
GO:BP GO:0050789 regulation of biological process 0.0151209172000905 12091 44 39 0.886363636363636 0.00322553965759656
GO:BP GO:0048839 inner ear development 0.0153997963799954 193 142 7 0.0492957746478873 0.0362694300518135
GO:BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 0.0155860877601414 162 82 5 0.0609756097560976 0.0308641975308642
GO:BP GO:0051216 cartilage development 0.0158164496748357 196 103 6 0.058252427184466 0.0306122448979592
GO:BP GO:0048519 negative regulation of biological process 0.0159965858596466 5757 62 32 0.516129032258065 0.0055584505819003
GO:BP GO:0070265 necrotic cell death 0.0162110380767979 68 51 3 0.0588235294117647 0.0441176470588235
GO:BP GO:0042221 response to chemical 0.0169767863191802 4781 82 35 0.426829268292683 0.00732064421669107
GO:BP GO:0032879 regulation of localization 0.0170287729769279 2872 41 15 0.365853658536585 0.00522284122562674
GO:BP GO:0051058 negative regulation of small GTPase mediated signal transduction 0.0171062131199607 57 142 4 0.028169014084507 0.0701754385964912
GO:BP GO:0048640 negative regulation of developmental growth 0.0171062131199607 112 124 5 0.0403225806451613 0.0446428571428571
GO:BP GO:0051091 positive regulation of DNA-binding transcription factor activity 0.0171062131199607 270 52 5 0.0961538461538462 0.0185185185185185
GO:BP GO:0001837 epithelial to mesenchymal transition 0.0171062131199607 156 133 6 0.0451127819548872 0.0384615384615385
GO:BP GO:0040008 regulation of growth 0.0171062131199607 681 43 7 0.162790697674419 0.0102790014684288
GO:BP GO:0022604 regulation of cell morphogenesis 0.0173262128223044 309 93 7 0.0752688172043011 0.0226537216828479
GO:BP GO:0022600 digestive system process 0.0175192800021132 102 80 4 0.05 0.0392156862745098
GO:BP GO:0090596 sensory organ morphogenesis 0.0176050766834573 262 142 8 0.0563380281690141 0.0305343511450382
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.0177980500682089 1202 142 20 0.140845070422535 0.0166389351081531
GO:BP GO:0045595 regulation of cell differentiation 0.0179050192599397 1679 61 14 0.229508196721311 0.0083382966051221
GO:BP GO:0046620 regulation of organ growth 0.0179763055958343 111 128 5 0.0390625 0.045045045045045
GO:BP GO:0060071 Wnt signaling pathway, planar cell polarity pathway 0.0181624524890159 110 130 5 0.0384615384615385 0.0454545454545455
GO:BP GO:0008360 regulation of cell shape 0.0181624524890159 154 93 5 0.0537634408602151 0.0324675324675325
GO:BP GO:0060675 ureteric bud morphogenesis 0.0181624524890159 62 135 4 0.0296296296296296 0.0645161290322581
GO:BP GO:1905954 positive regulation of lipid localization 0.0185086139273971 113 34 3 0.0882352941176471 0.0265486725663717
GO:BP GO:0032501 multicellular organismal process 0.0185558321939992 7946 61 39 0.639344262295082 0.00490812987666751
GO:BP GO:0072171 mesonephric tubule morphogenesis 0.0186798383223453 63 135 4 0.0296296296296296 0.0634920634920635
GO:BP GO:0090066 regulation of anatomical structure size 0.0188538953179475 518 58 7 0.120689655172414 0.0135135135135135
GO:BP GO:0045926 negative regulation of growth 0.0188538953179475 255 34 4 0.117647058823529 0.0156862745098039
GO:BP GO:0065007 biological regulation 0.0188726762249343 12809 64 56 0.875 0.00437192598953861
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0190744865058292 982 103 14 0.135922330097087 0.0142566191446029
GO:BP GO:0030856 regulation of epithelial cell differentiation 0.0191735729551157 164 133 6 0.0451127819548872 0.0365853658536585
GO:BP GO:0090175 regulation of establishment of planar polarity 0.0197028264709166 114 130 5 0.0384615384615385 0.043859649122807
GO:BP GO:1990778 protein localization to cell periphery 0.0197140644731894 338 142 9 0.0633802816901408 0.0266272189349112
GO:BP GO:0072009 nephron epithelium development 0.0197140644731894 110 135 5 0.037037037037037 0.0454545454545455
GO:BP GO:0060485 mesenchyme development 0.0197140644731894 291 133 8 0.0601503759398496 0.0274914089347079
GO:BP GO:0045321 leukocyte activation 0.0203602126610151 1332 4 3 0.75 0.00225225225225225
GO:BP GO:0050673 epithelial cell proliferation 0.0204567075207769 460 86 8 0.0930232558139535 0.0173913043478261
GO:BP GO:0051094 positive regulation of developmental process 0.0204567075207769 1341 4 3 0.75 0.00223713646532438
GO:BP GO:0042303 molting cycle 0.0204567075207769 112 80 4 0.05 0.0357142857142857
GO:BP GO:0042633 hair cycle 0.0204567075207769 112 80 4 0.05 0.0357142857142857
GO:BP GO:0051270 regulation of cellular component movement 0.0206499141390955 1141 111 16 0.144144144144144 0.014022787028922
GO:BP GO:0045668 negative regulation of osteoblast differentiation 0.0212883683813599 53 80 3 0.0375 0.0566037735849057
GO:BP GO:0043583 ear development 0.02135178920195 218 142 7 0.0492957746478873 0.0321100917431193
GO:BP GO:0090263 positive regulation of canonical Wnt signaling pathway 0.02135178920195 151 61 4 0.0655737704918033 0.0264900662251656
GO:BP GO:0072659 protein localization to plasma membrane 0.0223199442855278 283 142 8 0.0563380281690141 0.0282685512367491
GO:BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 0.0223924553775751 159 59 4 0.0677966101694915 0.0251572327044025
GO:BP GO:0099174 regulation of presynapse organization 0.0225382141344597 34 130 3 0.0230769230769231 0.0882352941176471
GO:BP GO:0046330 positive regulation of JNK cascade 0.0225382141344597 86 51 3 0.0588235294117647 0.0348837209302326
GO:BP GO:0045892 negative regulation of transcription, DNA-templated 0.0225382141344597 1337 124 19 0.153225806451613 0.0142109199700823
GO:BP GO:1905606 regulation of presynapse assembly 0.0225382141344597 34 130 3 0.0230769230769231 0.0882352941176471
GO:BP GO:0044344 cellular response to fibroblast growth factor stimulus 0.0225382141344597 147 30 3 0.1 0.0204081632653061
GO:BP GO:0045669 positive regulation of osteoblast differentiation 0.0226095964944416 70 135 4 0.0296296296296296 0.0571428571428571
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 0.0226416997218932 1339 124 19 0.153225806451613 0.0141896938013443
GO:BP GO:0051090 regulation of DNA-binding transcription factor activity 0.0226416997218932 456 52 6 0.115384615384615 0.0131578947368421
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 0.0227598357254492 1341 124 19 0.153225806451613 0.0141685309470544
GO:BP GO:0071902 positive regulation of protein serine/threonine kinase activity 0.0227598357254492 316 51 5 0.0980392156862745 0.0158227848101266
GO:BP GO:0060429 epithelium development 0.022835813435201 1325 135 20 0.148148148148148 0.0150943396226415
GO:BP GO:0034605 cellular response to heat 0.022835813435201 118 38 3 0.0789473684210526 0.0254237288135593
GO:BP GO:0072078 nephron tubule morphogenesis 0.0229629577896021 71 135 4 0.0296296296296296 0.0563380281690141
GO:BP GO:0071774 response to fibroblast growth factor 0.0231063792934089 153 30 3 0.1 0.0196078431372549
GO:BP GO:2000145 regulation of cell motility 0.023190828284161 1061 111 15 0.135135135135135 0.0141376060320452
GO:BP GO:0007155 cell adhesion 0.0236229260195979 1492 4 3 0.75 0.00201072386058981
GO:BP GO:2000026 regulation of multicellular organismal development 0.0236245016393666 1447 59 12 0.203389830508475 0.0082930200414651
GO:BP GO:0001775 cell activation 0.0236245016393666 1495 4 3 0.75 0.0020066889632107
GO:BP GO:0022610 biological adhesion 0.0236245016393666 1499 4 3 0.75 0.00200133422281521
GO:BP GO:0000902 cell morphogenesis 0.0236941625692623 1037 114 15 0.131578947368421 0.0144648023143684
GO:BP GO:0007605 sensory perception of sound 0.0236941625692623 153 107 5 0.0467289719626168 0.0326797385620915
GO:BP GO:0072088 nephron epithelium morphogenesis 0.0237038491867627 73 135 4 0.0296296296296296 0.0547945205479452
GO:BP GO:0006986 response to unfolded protein 0.0240155182938494 184 54 4 0.0740740740740741 0.0217391304347826
GO:BP GO:0090287 regulation of cellular response to growth factor stimulus 0.0241290676068758 315 133 8 0.0601503759398496 0.0253968253968254
GO:BP GO:0016477 cell migration 0.0241290676068758 1649 111 20 0.18018018018018 0.0121285627653123
GO:BP GO:0034220 ion transmembrane transport 0.0241290676068758 1397 46 10 0.217391304347826 0.00715819613457409
GO:BP GO:0072028 nephron morphogenesis 0.0243695017605223 75 135 4 0.0296296296296296 0.0533333333333333
GO:BP GO:0009893 positive regulation of metabolic process 0.0245811174499959 3783 80 28 0.35 0.00740153317472905
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.0246328141532491 3483 63 22 0.349206349206349 0.00631639391329314
GO:BP GO:0007164 establishment of tissue polarity 0.0248549110807483 130 130 5 0.0384615384615385 0.0384615384615385
GO:BP GO:0001736 establishment of planar polarity 0.0248549110807483 130 130 5 0.0384615384615385 0.0384615384615385
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 0.0248549110807483 1851 73 16 0.219178082191781 0.00864397622906537
GO:BP GO:0046328 regulation of JNK cascade 0.0249145144547739 133 77 4 0.051948051948052 0.0300751879699248
GO:BP GO:0031334 positive regulation of protein-containing complex assembly 0.0253000646321172 263 127 7 0.0551181102362205 0.026615969581749
GO:BP GO:0003007 heart morphogenesis 0.0253000646321172 251 133 7 0.0526315789473684 0.0278884462151394
GO:BP GO:0104004 cellular response to environmental stimulus 0.0254032674225386 339 99 7 0.0707070707070707 0.0206489675516224
GO:BP GO:0071214 cellular response to abiotic stimulus 0.0254032674225386 339 99 7 0.0707070707070707 0.0206489675516224
GO:BP GO:0034097 response to cytokine 0.0256474574646155 1226 99 15 0.151515151515152 0.0122349102773246
GO:BP GO:0071417 cellular response to organonitrogen compound 0.0256474574646155 666 80 9 0.1125 0.0135135135135135
GO:BP GO:0002682 regulation of immune system process 0.0256474574646155 1617 4 3 0.75 0.00185528756957328
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.0258977489908287 1227 109 16 0.146788990825688 0.013039934800326
GO:BP GO:0038179 neurotrophin signaling pathway 0.0258977489908287 38 133 3 0.0225563909774436 0.0789473684210526
GO:BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0272404036769726 257 133 7 0.0526315789473684 0.0272373540856031
GO:BP GO:0071230 cellular response to amino acid stimulus 0.0272646002895605 68 76 3 0.0394736842105263 0.0441176470588235
GO:BP GO:0032092 positive regulation of protein binding 0.0274247333926016 85 61 3 0.0491803278688525 0.0352941176470588
GO:BP GO:0040012 regulation of locomotion 0.0275039562487521 1104 111 15 0.135135135135135 0.0135869565217391
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 0.0275039562487521 1887 73 16 0.219178082191781 0.00847906730259671
GO:BP GO:0030334 regulation of cell migration 0.0285158078449493 999 111 14 0.126126126126126 0.014014014014014
GO:BP GO:1904375 regulation of protein localization to cell periphery 0.0285859525319471 126 142 5 0.0352112676056338 0.0396825396825397
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.0286298696957399 1103 80 12 0.15 0.0108794197642792
GO:BP GO:0090102 cochlea development 0.0287200513203014 49 109 3 0.0275229357798165 0.0612244897959184
GO:BP GO:0050794 regulation of cellular process 0.0288175835466569 11473 35 30 0.857142857142857 0.00261483482959993
GO:BP GO:0035966 response to topologically incorrect protein 0.0289001121881053 205 54 4 0.0740740740740741 0.0195121951219512
GO:BP GO:0031345 negative regulation of cell projection organization 0.0293016619333898 189 59 4 0.0677966101694915 0.0211640211640212
GO:BP GO:2000278 regulation of DNA biosynthetic process 0.0293016619333898 112 99 4 0.0404040404040404 0.0357142857142857
GO:BP GO:0071345 cellular response to cytokine stimulus 0.0293016619333898 1132 99 14 0.141414141414141 0.0123674911660777
GO:BP GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0293016619333898 136 133 5 0.037593984962406 0.0367647058823529
GO:BP GO:0048870 cell motility 0.0295107160890821 1828 111 21 0.189189189189189 0.0114879649890591
GO:BP GO:0051674 localization of cell 0.0295107160890821 1828 111 21 0.189189189189189 0.0114879649890591
GO:BP GO:0007586 digestion 0.0295260618135516 141 80 4 0.05 0.0283687943262411
GO:BP GO:0042493 response to drug 0.0295260618135516 396 139 9 0.0647482014388489 0.0227272727272727
GO:BP GO:0050679 positive regulation of epithelial cell proliferation 0.0295260618135516 213 86 5 0.0581395348837209 0.0234741784037559
GO:BP GO:0007507 heart development 0.0297448545472543 578 133 11 0.0827067669172932 0.0190311418685121
GO:BP GO:0001656 metanephros development 0.0301396068560935 86 133 4 0.0300751879699248 0.0465116279069767
GO:BP GO:0050954 sensory perception of mechanical stimulus 0.0301970533155261 174 107 5 0.0467289719626168 0.028735632183908
GO:BP GO:0044093 positive regulation of molecular function 0.0301970533155261 1771 52 12 0.230769230769231 0.00677583286278938
GO:BP GO:0045597 positive regulation of cell differentiation 0.030263992515581 879 142 15 0.105633802816901 0.0170648464163823
GO:BP GO:0060249 anatomical structure homeostasis 0.030263992515581 482 116 9 0.0775862068965517 0.0186721991701245
GO:BP GO:0070373 negative regulation of ERK1 and ERK2 cascade 0.030263992515581 81 142 4 0.028169014084507 0.0493827160493827
GO:BP GO:0031397 negative regulation of protein ubiquitination 0.0305442123125611 83 69 3 0.0434782608695652 0.036144578313253
GO:BP GO:0043410 positive regulation of MAPK cascade 0.0305442123125611 539 51 6 0.117647058823529 0.0111317254174397
GO:BP GO:0035019 somatic stem cell population maintenance 0.0305866962641981 72 80 3 0.0375 0.0416666666666667
GO:BP GO:0030010 establishment of cell polarity 0.0305866962641981 142 133 5 0.037593984962406 0.0352112676056338
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.0306773574234608 549 142 11 0.0774647887323944 0.0200364298724954
GO:BP GO:0061041 regulation of wound healing 0.0306773574234608 136 86 4 0.0465116279069767 0.0294117647058824
GO:BP GO:0071229 cellular response to acid chemical 0.0306773574234608 76 76 3 0.0394736842105263 0.0394736842105263
GO:BP GO:0035329 hippo signaling 0.0308804171823419 47 124 3 0.0241935483870968 0.0638297872340425
GO:BP GO:0051128 regulation of cellular component organization 0.0310168245933138 2412 109 25 0.229357798165138 0.0103648424543947
GO:BP GO:0000278 mitotic cell cycle 0.0312117687637402 1059 45 8 0.177777777777778 0.00755429650613787
GO:BP GO:0007179 transforming growth factor beta receptor signaling pathway 0.0313688674338884 206 133 6 0.0451127819548872 0.029126213592233
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 0.0314619504596788 1707 35 9 0.257142857142857 0.00527240773286467
GO:BP GO:0072006 nephron development 0.0315014225150827 142 135 5 0.037037037037037 0.0352112676056338
GO:BP GO:0006928 movement of cell or subcellular component 0.0317364805935563 2311 114 25 0.219298245614035 0.0108178277801817
GO:BP GO:0051253 negative regulation of RNA metabolic process 0.0317364805935563 1445 124 19 0.153225806451613 0.0131487889273356
GO:BP GO:0071398 cellular response to fatty acid 0.0317364805935563 43 139 3 0.0215827338129496 0.0697674418604651
GO:BP GO:0032526 response to retinoic acid 0.0317364805935563 110 109 4 0.036697247706422 0.0363636363636364
GO:BP GO:0051130 positive regulation of cellular component organization 0.0318526731421319 1153 6 3 0.5 0.002601908065915
GO:BP GO:0009408 response to heat 0.0318526731421319 159 38 3 0.0789473684210526 0.0188679245283019
GO:BP GO:0070371 ERK1 and ERK2 cascade 0.0318526731421319 329 142 8 0.0563380281690141 0.0243161094224924
GO:BP GO:1901699 cellular response to nitrogen compound 0.0321920894004632 724 80 9 0.1125 0.0124309392265193
GO:BP GO:0019827 stem cell population maintenance 0.0321971022237365 152 80 4 0.05 0.0263157894736842
GO:BP GO:0035567 non-canonical Wnt signaling pathway 0.0322357569755189 151 130 5 0.0384615384615385 0.033112582781457
GO:BP GO:0048732 gland development 0.0322357569755189 436 86 7 0.0813953488372093 0.0160550458715596
GO:BP GO:0032874 positive regulation of stress-activated MAPK cascade 0.0324235626459926 121 51 3 0.0588235294117647 0.0247933884297521
GO:BP GO:0009890 negative regulation of biosynthetic process 0.0324235626459926 1740 35 9 0.257142857142857 0.00517241379310345
GO:BP GO:0001738 morphogenesis of a polarized epithelium 0.0324466987907267 152 130 5 0.0384615384615385 0.0328947368421053
GO:BP GO:0098727 maintenance of cell number 0.0324466987907267 154 80 4 0.05 0.025974025974026
GO:BP GO:0031333 negative regulation of protein-containing complex assembly 0.0328309269752922 147 135 5 0.037037037037037 0.0340136054421769
GO:BP GO:0030335 positive regulation of cell migration 0.0332442470304614 567 103 9 0.087378640776699 0.0158730158730159
GO:BP GO:0048708 astrocyte differentiation 0.0332442470304614 78 80 3 0.0375 0.0384615384615385
GO:BP GO:0033043 regulation of organelle organization 0.0332442470304614 1203 6 3 0.5 0.00249376558603491
GO:BP GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 0.0332442470304614 123 51 3 0.0588235294117647 0.024390243902439
GO:BP GO:0034260 negative regulation of GTPase activity 0.0339777347572483 48 133 3 0.0225563909774436 0.0625
GO:BP GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 0.0339777347572483 108 59 3 0.0508474576271186 0.0277777777777778
GO:BP GO:0048704 embryonic skeletal system morphogenesis 0.0339777347572483 94 134 4 0.0298507462686567 0.0425531914893617
GO:BP GO:0071260 cellular response to mechanical stimulus 0.0342187906111537 80 80 3 0.0375 0.0375
GO:BP GO:0009891 positive regulation of biosynthetic process 0.0347143467370822 2004 73 16 0.219178082191781 0.00798403193612774
GO:BP GO:0051254 positive regulation of RNA metabolic process 0.0347143467370822 1714 63 13 0.206349206349206 0.00758459743290548
GO:BP GO:1903321 negative regulation of protein modification by small protein conjugation or removal 0.0358955869569095 96 69 3 0.0434782608695652 0.03125
GO:BP GO:2000573 positive regulation of DNA biosynthetic process 0.0358955869569095 67 99 3 0.0303030303030303 0.0447761194029851
GO:BP GO:0042060 wound healing 0.0358955869569095 549 109 9 0.0825688073394495 0.0163934426229508
GO:BP GO:0099054 presynapse assembly 0.0358955869569095 51 130 3 0.0230769230769231 0.0588235294117647
GO:BP GO:0006813 potassium ion transport 0.0358955869569095 249 27 3 0.111111111111111 0.0120481927710843
GO:BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 0.035952272620116 369 133 8 0.0601503759398496 0.021680216802168
GO:BP GO:0008038 neuron recognition 0.035952272620116 47 142 3 0.0211267605633803 0.0638297872340425
GO:BP GO:0097191 extrinsic apoptotic signaling pathway 0.0361582404052836 223 59 4 0.0677966101694915 0.0179372197309417
GO:BP GO:0060688 regulation of morphogenesis of a branching structure 0.0361935825286844 50 134 3 0.0223880597014925 0.06
GO:BP GO:0043066 negative regulation of apoptotic process 0.0361935825286844 921 103 12 0.116504854368932 0.0130293159609121
GO:BP GO:1902531 regulation of intracellular signal transduction 0.0363051364027996 1842 94 18 0.191489361702128 0.00977198697068404
GO:BP GO:0055017 cardiac muscle tissue growth 0.0365811154168245 103 128 4 0.03125 0.0388349514563107
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.0368786279040586 3083 80 23 0.2875 0.00746026597469997
GO:BP GO:1905952 regulation of lipid localization 0.0370939327182503 201 34 3 0.0882352941176471 0.0149253731343284
GO:BP GO:0030199 collagen fibril organization 0.0370939327182503 58 117 3 0.0256410256410256 0.0517241379310345
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.037185716553792 3274 80 24 0.3 0.00733048259010385
GO:BP GO:0098739 import across plasma membrane 0.0372375017950629 163 42 3 0.0714285714285714 0.0184049079754601
GO:BP GO:0018105 peptidyl-serine phosphorylation 0.0372375017950629 313 43 4 0.0930232558139535 0.012779552715655
GO:BP GO:0071479 cellular response to ionizing radiation 0.0372510837900167 69 99 3 0.0303030303030303 0.0434782608695652
GO:BP GO:2000147 positive regulation of cell motility 0.0377286963402912 591 103 9 0.087378640776699 0.0152284263959391
GO:BP GO:0050714 positive regulation of protein secretion 0.0382285418631951 136 51 3 0.0588235294117647 0.0220588235294118
GO:BP GO:0099172 presynapse organization 0.0390726325357954 54 130 3 0.0230769230769231 0.0555555555555556
GO:BP GO:0001838 embryonic epithelial tube formation 0.0391493364111961 125 109 4 0.036697247706422 0.032
GO:BP GO:0055085 transmembrane transport 0.0391614005484402 1635 46 10 0.217391304347826 0.00611620795107034
GO:BP GO:0002576 platelet degranulation 0.0391614005484402 126 56 3 0.0535714285714286 0.0238095238095238
GO:BP GO:0045165 cell fate commitment 0.0391614005484402 267 81 5 0.0617283950617284 0.0187265917602996
GO:BP GO:0032940 secretion by cell 0.0396680625992016 1364 6 3 0.5 0.00219941348973607
GO:BP GO:0007626 locomotory behavior 0.0396680625992016 189 73 4 0.0547945205479452 0.0211640211640212
GO:BP GO:0035725 sodium ion transmembrane transport 0.0398563433897017 171 42 3 0.0714285714285714 0.0175438596491228
GO:BP GO:0043069 negative regulation of programmed cell death 0.0398563433897017 943 103 12 0.116504854368932 0.0127253446447508
GO:BP GO:1901700 response to oxygen-containing compound 0.0398563433897017 1739 86 16 0.186046511627907 0.00920069005175388
GO:BP GO:2000113 negative regulation of cellular macromolecule biosynthetic process 0.0398563433897017 1628 124 20 0.161290322580645 0.0122850122850123
GO:BP GO:0071773 cellular response to BMP stimulus 0.0401329903701071 171 128 5 0.0390625 0.0292397660818713
GO:BP GO:0071772 response to BMP 0.0401329903701071 171 128 5 0.0390625 0.0292397660818713
GO:BP GO:0060537 muscle tissue development 0.0402512255096576 399 128 8 0.0625 0.0200501253132832
GO:BP GO:0051272 positive regulation of cellular component movement 0.0402547240862232 604 103 9 0.087378640776699 0.0149006622516556
GO:BP GO:0040017 positive regulation of locomotion 0.0406831379067812 606 103 9 0.087378640776699 0.0148514851485149
GO:BP GO:0048762 mesenchymal cell differentiation 0.0406831379067812 234 133 6 0.0451127819548872 0.0256410256410256
GO:BP GO:0048736 appendage development 0.0406831379067812 176 80 4 0.05 0.0227272727272727
GO:BP GO:0051963 regulation of synapse assembly 0.0406831379067812 99 142 4 0.028169014084507 0.0404040404040404
GO:BP GO:0060173 limb development 0.0406831379067812 176 80 4 0.05 0.0227272727272727
GO:BP GO:0071300 cellular response to retinoic acid 0.0406831379067812 67 109 3 0.0275229357798165 0.0447761194029851
GO:BP GO:0060043 regulation of cardiac muscle cell proliferation 0.0406831379067812 57 128 3 0.0234375 0.0526315789473684
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 0.0410927051264692 1639 124 20 0.161290322580645 0.012202562538133
GO:BP GO:0043269 regulation of ion transport 0.0413166041354242 1379 55 10 0.181818181818182 0.00725163161711385
GO:BP GO:0000165 MAPK cascade 0.0413166041354242 935 80 10 0.125 0.0106951871657754
GO:BP GO:0032535 regulation of cellular component size 0.0413166041354242 388 58 5 0.0862068965517241 0.0128865979381443
GO:BP GO:0060419 heart growth 0.041325187975262 111 128 4 0.03125 0.036036036036036
GO:BP GO:0140352 export from cell 0.041430402458649 1418 6 3 0.5 0.00211565585331453
GO:BP GO:0030705 cytoskeleton-dependent intracellular transport 0.0415682806303329 202 37 3 0.0810810810810811 0.0148514851485149
GO:BP GO:0018209 peptidyl-serine modification 0.0417436681397998 336 43 4 0.0930232558139535 0.0119047619047619
GO:BP GO:0009628 response to abiotic stimulus 0.042953560510992 1261 99 14 0.141414141414141 0.0111022997620936
GO:BP GO:1903034 regulation of response to wounding 0.0432097522143798 169 86 4 0.0465116279069767 0.0236686390532544
GO:BP GO:0032872 regulation of stress-activated MAPK cascade 0.0433028000338908 190 77 4 0.051948051948052 0.0210526315789474
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.0433028000338908 2719 124 29 0.233870967741935 0.0106656859139389
GO:BP GO:0030500 regulation of bone mineralization 0.0433028000338908 74 103 3 0.029126213592233 0.0405405405405405
GO:BP GO:0097435 supramolecular fiber organization 0.0433028000338908 734 58 7 0.120689655172414 0.00953678474114441
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 0.0438790637773919 1548 124 19 0.153225806451613 0.0122739018087855
GO:BP GO:0045893 positive regulation of transcription, DNA-templated 0.0440844970565639 1617 63 12 0.19047619047619 0.00742115027829314
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 0.0440844970565639 1617 63 12 0.19047619047619 0.00742115027829314
GO:BP GO:0030324 lung development 0.0440844970565639 173 133 5 0.037593984962406 0.0289017341040462
GO:BP GO:0007399 nervous system development 0.0441722668307551 2449 114 25 0.219298245614035 0.0102082482645978
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 0.0441722668307551 1618 63 12 0.19047619047619 0.00741656365883807
GO:BP GO:0010243 response to organonitrogen compound 0.0441811310618106 1085 104 13 0.125 0.0119815668202765
GO:BP GO:0051247 positive regulation of protein metabolic process 0.0441811310618106 1564 106 17 0.160377358490566 0.0108695652173913
GO:BP GO:0007498 mesoderm development 0.0441811310618106 132 59 3 0.0508474576271186 0.0227272727272727
GO:BP GO:0070302 regulation of stress-activated protein kinase signaling cascade 0.0441811310618106 193 77 4 0.051948051948052 0.0207253886010363
GO:BP GO:0046622 positive regulation of organ growth 0.0441811310618106 61 128 3 0.0234375 0.0491803278688525
GO:BP GO:0032731 positive regulation of interleukin-1 beta production 0.0441811310618106 56 139 3 0.0215827338129496 0.0535714285714286
GO:BP GO:0046903 secretion 0.0445373350026468 1501 6 3 0.5 0.00199866755496336
GO:BP GO:0051179 localization 0.0445373350026468 6901 42 24 0.571428571428571 0.00347775684683379
GO:BP GO:1903076 regulation of protein localization to plasma membrane 0.0445373350026468 105 142 4 0.028169014084507 0.0380952380952381
GO:BP GO:0098609 cell-cell adhesion 0.0445373350026468 894 140 14 0.1 0.0156599552572707
GO:BP GO:0072175 epithelial tube formation 0.0445834592803503 137 109 4 0.036697247706422 0.0291970802919708
GO:BP GO:0007254 JNK cascade 0.0448734823065191 195 77 4 0.051948051948052 0.0205128205128205
GO:BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 0.0449673998792968 215 70 4 0.0571428571428571 0.0186046511627907
GO:BP GO:0060349 bone morphogenesis 0.0449673998792968 99 80 3 0.0375 0.0303030303030303
GO:BP GO:0021700 developmental maturation 0.0451275006303337 275 55 4 0.0727272727272727 0.0145454545454545
GO:BP GO:0071346 cellular response to interferon-gamma 0.0451275006303337 175 86 4 0.0465116279069767 0.0228571428571429
GO:BP GO:0010941 regulation of cell death 0.0451446975774023 1720 82 15 0.182926829268293 0.00872093023255814
GO:BP GO:0034765 regulation of ion transmembrane transport 0.0453773336475732 583 41 5 0.121951219512195 0.00857632933104631
GO:BP GO:0030323 respiratory tube development 0.0456213192506113 177 133 5 0.037593984962406 0.0282485875706215
GO:BP GO:0031401 positive regulation of protein modification process 0.0456213192506113 1074 106 13 0.122641509433962 0.0121042830540037
GO:BP GO:0034762 regulation of transmembrane transport 0.0461596659387672 588 41 5 0.121951219512195 0.00850340136054422
GO:BP GO:0002793 positive regulation of peptide secretion 0.0461632113987259 159 51 3 0.0588235294117647 0.0188679245283019
GO:BP GO:0044089 positive regulation of cellular component biogenesis 0.0461632113987259 540 142 10 0.0704225352112676 0.0185185185185185
GO:BP GO:0008543 fibroblast growth factor receptor signaling pathway 0.0462551086786302 116 70 3 0.0428571428571429 0.0258620689655172
GO:BP GO:0042592 homeostatic process 0.0462551086786302 1981 99 19 0.191919191919192 0.00959111559818274
GO:BP GO:0009896 positive regulation of catabolic process 0.0468805017658756 464 94 7 0.074468085106383 0.0150862068965517
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 0.0480281547634219 1967 73 15 0.205479452054795 0.00762582613116421
GO:BP GO:0098656 anion transmembrane transport 0.0480877891043918 550 120 9 0.075 0.0163636363636364
GO:BP GO:0070372 regulation of ERK1 and ERK2 cascade 0.0482851155542917 309 142 7 0.0492957746478873 0.0226537216828479
GO:BP GO:0042593 glucose homeostasis 0.0484322559274801 248 34 3 0.0882352941176471 0.0120967741935484
GO:BP GO:0033500 carbohydrate homeostasis 0.0486695181087889 249 34 3 0.0882352941176471 0.0120481927710843
GO:BP GO:0060038 cardiac muscle cell proliferation 0.0491411090274489 66 128 3 0.0234375 0.0454545454545455
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.0492097445349716 306 28 3 0.107142857142857 0.00980392156862745
GO:BP GO:0006457 protein folding 0.0494599116558531 225 38 3 0.0789473684210526 0.0133333333333333
GO:BP GO:0050854 regulation of antigen receptor-mediated signaling pathway 0.0494599116558531 68 125 3 0.024 0.0441176470588235
GO:BP GO:0002376 immune system process 0.049904411041654 3278 6 4 0.666666666666667 0.0012202562538133
GO:CC GO:0071944 cell periphery 5.268634921488e-05 6169 61 40 0.655737704918033 0.00648403306856865
GO:CC GO:0005887 integral component of plasma membrane 0.000643515100650465 1645 128 28 0.21875 0.0170212765957447
GO:CC GO:0031226 intrinsic component of plasma membrane 0.000643515100650465 1726 130 29 0.223076923076923 0.0168018539976825
GO:CC GO:0001726 ruffle 0.0018131840030096 179 58 6 0.103448275862069 0.0335195530726257
GO:CC GO:0005886 plasma membrane 0.0018131840030096 5681 61 34 0.557377049180328 0.00598486182010209
GO:CC GO:0070161 anchoring junction 0.0018131840030096 836 122 17 0.139344262295082 0.0203349282296651
GO:CC GO:0005604 basement membrane 0.00193948879261928 97 13 3 0.230769230769231 0.0309278350515464
GO:CC GO:0031252 cell leading edge 0.00193948879261928 422 58 8 0.137931034482759 0.018957345971564
GO:CC GO:0005790 smooth endoplasmic reticulum 0.00193948879261928 34 37 3 0.0810810810810811 0.0882352941176471
GO:CC GO:0036477 somatodendritic compartment 0.0042473189188411 871 42 9 0.214285714285714 0.0103329506314581
GO:CC GO:0030054 cell junction 0.00530966857236922 2105 122 28 0.229508196721311 0.0133016627078385
GO:CC GO:0005581 collagen trimer 0.00679961152121345 95 57 4 0.0701754385964912 0.0421052631578947
GO:CC GO:0120025 plasma membrane bounded cell projection 0.00733267681958943 2229 58 17 0.293103448275862 0.00762673844773441
GO:CC GO:0062023 collagen-containing extracellular matrix 0.00733267681958943 421 57 7 0.12280701754386 0.0166270783847981
GO:CC GO:0098590 plasma membrane region 0.00834438232543973 1240 58 12 0.206896551724138 0.00967741935483871
GO:CC GO:0030141 secretory granule 0.00877090286042437 851 4 3 0.75 0.00352526439482961
GO:CC GO:0005925 focal adhesion 0.0098892245184975 420 82 8 0.0975609756097561 0.019047619047619
GO:CC GO:0042995 cell projection 0.0098892245184975 2330 58 17 0.293103448275862 0.00729613733905579
GO:CC GO:0098794 postsynapse 0.0098892245184975 639 42 7 0.166666666666667 0.0109546165884194
GO:CC GO:0099503 secretory vesicle 0.010126140036412 1020 4 3 0.75 0.00294117647058824
GO:CC GO:0005783 endoplasmic reticulum 0.010126140036412 1982 75 18 0.24 0.00908173562058527
GO:CC GO:0031253 cell projection membrane 0.010126140036412 343 58 6 0.103448275862069 0.0174927113702624
GO:CC GO:0030055 cell-substrate junction 0.010126140036412 427 82 8 0.0975609756097561 0.0187353629976581
GO:CC GO:0014069 postsynaptic density 0.0112067318417213 334 41 5 0.121951219512195 0.0149700598802395
GO:CC GO:0048471 perinuclear region of cytoplasm 0.0112067318417213 735 51 8 0.156862745098039 0.0108843537414966
GO:CC GO:0032279 asymmetric synapse 0.0113314968885057 340 41 5 0.121951219512195 0.0147058823529412
GO:CC GO:0045177 apical part of cell 0.0125453828486324 431 50 6 0.12 0.0139211136890951
GO:CC GO:0031012 extracellular matrix 0.0132578811044354 562 16 4 0.25 0.00711743772241993
GO:CC GO:0030312 external encapsulating structure 0.0132578811044354 563 16 4 0.25 0.00710479573712256
GO:CC GO:0099572 postsynaptic specialization 0.0132578811044354 358 41 5 0.121951219512195 0.0139664804469274
GO:CC GO:0098984 neuron to neuron synapse 0.0135022368011941 366 41 5 0.121951219512195 0.0136612021857923
GO:CC GO:0043005 neuron projection 0.0145849104264001 1380 45 10 0.222222222222222 0.0072463768115942
GO:CC GO:0005615 extracellular space 0.0149146538864155 3594 4 4 1 0.00111296605453534
GO:CC GO:0015630 microtubule cytoskeleton 0.0149893005226138 1307 40 9 0.225 0.00688599846977812
GO:CC GO:0099240 intrinsic component of synaptic membrane 0.0150319560608792 162 142 6 0.0422535211267606 0.037037037037037
GO:CC GO:0070062 extracellular exosome 0.0157612742472842 2176 3 3 1 0.00137867647058824
GO:CC GO:1903561 extracellular vesicle 0.0169046721251946 2261 3 3 1 0.00132684652808492
GO:CC GO:0043230 extracellular organelle 0.0169046721251946 2263 3 3 1 0.00132567388422448
GO:CC GO:0099055 integral component of postsynaptic membrane 0.0172167012497923 116 142 5 0.0352112676056338 0.0431034482758621
GO:CC GO:0031982 vesicle 0.0182537645222056 4055 4 4 1 0.000986436498150432
GO:CC GO:0016323 basolateral plasma membrane 0.0182537645222056 222 46 4 0.0869565217391304 0.018018018018018
GO:CC GO:0005874 microtubule 0.0182537645222056 434 40 5 0.125 0.0115207373271889
GO:CC GO:0005788 endoplasmic reticulum lumen 0.0186550953045904 307 57 5 0.087719298245614 0.0162866449511401
GO:CC GO:0098936 intrinsic component of postsynaptic membrane 0.0186550953045904 122 142 5 0.0352112676056338 0.040983606557377
GO:CC GO:0016020 membrane 0.0197801692888761 9838 86 58 0.674418604651163 0.00589550721691401
GO:CC GO:0030425 dendrite 0.0209505393253212 638 42 6 0.142857142857143 0.00940438871473354
GO:CC GO:0097447 dendritic tree 0.0209505393253212 640 42 6 0.142857142857143 0.009375
GO:CC GO:0009925 basal plasma membrane 0.0218086247586356 247 46 4 0.0869565217391304 0.0161943319838057
GO:CC GO:0031410 cytoplasmic vesicle 0.0218086247586356 2424 82 20 0.24390243902439 0.00825082508250825
GO:CC GO:0097708 intracellular vesicle 0.0218086247586356 2428 82 20 0.24390243902439 0.00823723228995058
GO:CC GO:0032587 ruffle membrane 0.0226337558978538 96 58 3 0.0517241379310345 0.03125
GO:CC GO:0005737 cytoplasm 0.0234749732190418 11911 38 32 0.842105263157895 0.00268659222567375
GO:CC GO:0005576 extracellular region 0.0234749732190418 4567 4 4 1 0.000875848478213269
GO:CC GO:0012505 endomembrane system 0.0234749732190418 4640 120 43 0.358333333333333 0.00926724137931034
GO:CC GO:0098857 membrane microdomain 0.0244227593670979 335 37 4 0.108108108108108 0.0119402985074627
GO:CC GO:0045121 membrane raft 0.0244227593670979 335 37 4 0.108108108108108 0.0119402985074627
GO:CC GO:0045178 basal part of cell 0.0244227593670979 265 46 4 0.0869565217391304 0.0150943396226415
GO:CC GO:0150034 distal axon 0.0252665472217481 308 41 4 0.0975609756097561 0.012987012987013
GO:CC GO:0005911 cell-cell junction 0.0270141301597733 494 122 9 0.0737704918032787 0.0182186234817814
GO:CC GO:0099699 integral component of synaptic membrane 0.0286785166177809 148 142 5 0.0352112676056338 0.0337837837837838
GO:CC GO:0043025 neuronal cell body 0.0302819283238723 518 42 5 0.119047619047619 0.00965250965250965
GO:CC GO:0030426 growth cone 0.0306750822729723 187 37 3 0.0810810810810811 0.0160427807486631
GO:CC GO:0030427 site of polarized growth 0.032655306448353 193 37 3 0.0810810810810811 0.0155440414507772
GO:CC GO:0034774 secretory granule lumen 0.0343117381876672 320 99 6 0.0606060606060606 0.01875
GO:CC GO:0031983 vesicle lumen 0.0353366821234124 326 99 6 0.0606060606060606 0.0184049079754601
GO:CC GO:0005856 cytoskeleton 0.0353366821234124 2332 40 11 0.275 0.00471698113207547
GO:CC GO:0031256 leading edge membrane 0.0353366821234124 175 83 4 0.0481927710843374 0.0228571428571429
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0353366821234124 324 99 6 0.0606060606060606 0.0185185185185185
GO:CC GO:0045202 synapse 0.0393344752221403 1349 42 8 0.19047619047619 0.00593031875463306
GO:CC GO:0099512 supramolecular fiber 0.0410655514633841 993 57 8 0.140350877192982 0.0080563947633434
GO:CC GO:0044297 cell body 0.0412751474880644 592 42 5 0.119047619047619 0.00844594594594595
GO:CC GO:0099081 supramolecular polymer 0.0412751474880644 1001 57 8 0.140350877192982 0.00799200799200799
GO:CC GO:0099060 integral component of postsynaptic specialization membrane 0.0432653885538949 74 115 3 0.0260869565217391 0.0405405405405405
GO:CC GO:0019867 outer membrane 0.0471343942392959 229 39 3 0.0769230769230769 0.0131004366812227
GO:CC GO:0043233 organelle lumen 0.0471343942392959 5565 137 53 0.386861313868613 0.00952380952380952
GO:CC GO:0031974 membrane-enclosed lumen 0.0471343942392959 5565 137 53 0.386861313868613 0.00952380952380952
GO:CC GO:0098948 intrinsic component of postsynaptic specialization membrane 0.0474077769204946 78 115 3 0.0260869565217391 0.0384615384615385
GO:CC GO:0005802 trans-Golgi network 0.0489140395488197 250 37 3 0.0810810810810811 0.012
GO:CC GO:0098858 actin-based cell projection 0.0489140395488197 220 42 3 0.0714285714285714 0.0136363636363636
GO:MF GO:0050839 cell adhesion molecule binding 6.71929545236531e-05 546 6 5 0.833333333333333 0.00915750915750916
GO:MF GO:0004629 phospholipase C activity 0.00686505529963662 28 41 3 0.0731707317073171 0.107142857142857
GO:MF GO:0045296 cadherin binding 0.00843680980409081 333 6 3 0.5 0.00900900900900901
GO:MF GO:0017147 Wnt-protein binding 0.00843680980409081 30 53 3 0.0566037735849057 0.1
GO:MF GO:0005201 extracellular matrix structural constituent 0.0109756932328801 171 57 5 0.087719298245614 0.0292397660818713
GO:MF GO:0005102 signaling receptor binding 0.0109756932328801 1672 61 15 0.245901639344262 0.00897129186602871
GO:MF GO:0016887 ATPase activity 0.0109756932328801 488 23 5 0.217391304347826 0.0102459016393443
GO:MF GO:0005109 frizzled binding 0.0109756932328801 37 61 3 0.0491803278688525 0.0810810810810811
GO:MF GO:0005198 structural molecule activity 0.0109756932328801 698 112 13 0.116071428571429 0.0186246418338109
GO:MF GO:0008201 heparin binding 0.0109756932328801 168 139 7 0.0503597122302158 0.0416666666666667
GO:MF GO:0030020 extracellular matrix structural constituent conferring tensile strength 0.0109756932328801 41 57 3 0.0526315789473684 0.0731707317073171
GO:MF GO:0005496 steroid binding 0.0196451418837306 100 34 3 0.0882352941176471 0.03
GO:MF GO:0005515 protein binding 0.0205767524526067 14767 95 87 0.91578947368421 0.00589151486422428
GO:MF GO:0008081 phosphoric diester hydrolase activity 0.0235620635752374 92 41 3 0.0731707317073171 0.0326086956521739
GO:MF GO:0004620 phospholipase activity 0.0285696144497432 109 143 5 0.034965034965035 0.0458715596330275
GO:MF GO:0005539 glycosaminoglycan binding 0.0330539885263837 238 139 7 0.0503597122302158 0.0294117647058824
GO:MF GO:0019904 protein domain specific binding 0.0363044622226489 710 8 3 0.375 0.00422535211267606
GO:MF GO:0001664 G protein-coupled receptor binding 0.0363044622226489 292 61 5 0.0819672131147541 0.0171232876712329
GO:MF GO:0019838 growth factor binding 0.0363044622226489 138 128 5 0.0390625 0.036231884057971
GO:MF GO:0003714 transcription corepressor activity 0.0376168829767586 187 59 4 0.0677966101694915 0.0213903743315508
GO:MF GO:0016298 lipase activity 0.039898824407606 134 41 3 0.0731707317073171 0.0223880597014925
GO:MF GO:0017111 nucleoside-triphosphatase activity 0.0416588114740833 872 23 5 0.217391304347826 0.00573394495412844
GO:MF GO:1901681 sulfur compound binding 0.0416588114740833 264 139 7 0.0503597122302158 0.0265151515151515
GO:MF GO:0015026 coreceptor activity 0.0449554477272666 47 130 3 0.0230769230769231 0.0638297872340425
GO:MF GO:0003712 transcription coregulator activity 0.0460586171080209 506 59 6 0.101694915254237 0.0118577075098814
GO:MF GO:0016817 hydrolase activity, acting on acid anhydrides 0.0460586171080209 930 23 5 0.217391304347826 0.00537634408602151
GO:MF GO:0016462 pyrophosphatase activity 0.0460586171080209 928 23 5 0.217391304347826 0.00538793103448276
GO:MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0460586171080209 930 23 5 0.217391304347826 0.00537634408602151
GO:MF GO:0042578 phosphoric ester hydrolase activity 0.0498703351027184 383 19 3 0.157894736842105 0.00783289817232376
TF TF:M10112 Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR 0.00138836123248694 8711 113 77 0.68141592920354 0.00883939846171507
TF TF:M09984_1 Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1 0.0022043029234781 5555 124 60 0.483870967741935 0.0108010801080108
TF TF:M10108 Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG 0.0022043029234781 6511 134 71 0.529850746268657 0.0109046229457841
TF TF:M10107_1 Factor: DB1; motif: GGRRRRGRRGGAGGGGGNGRRR; match class: 1 0.0022043029234781 2657 136 40 0.294117647058824 0.015054572826496
TF TF:M10112_1 Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR; match class: 1 0.00255276238099718 4075 22 15 0.681818181818182 0.00368098159509202
TF TF:M09968 Factor: KLF15; motif: RGGGMGGRGNNGGGGGNGG 0.00487479401943563 3157 119 39 0.327731092436975 0.0123535001583782
TF TF:M10108_1 Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG; match class: 1 0.0082888795451988 2864 124 37 0.298387096774194 0.0129189944134078
TF TF:M00189 Factor: AP-2; motif: MKCCCSCNGGCG 0.0231440236836437 10621 135 96 0.711111111111111 0.00903869692119386
TF TF:M10107 Factor: DB1; motif: GGRRRRGRRGGAGGGGGNGRRR 0.0291824474167619 5822 136 62 0.455882352941176 0.0106492614221917
TF TF:M01855_1 Factor: AHR; motif: CACGCN; match class: 1 0.0291824474167619 2796 88 27 0.306818181818182 0.00965665236051502
TF TF:M01118_1 Factor: WT1; motif: SMCNCCNSC; match class: 1 0.0291824474167619 2766 143 38 0.265734265734266 0.0137382501807664
TF TF:M01175 Factor: CKROX; motif: SCCCTCCCC 0.0291824474167619 7292 65 40 0.615384615384615 0.00548546352166758
TF TF:M01118 Factor: WT1; motif: SMCNCCNSC 0.0301098119657865 6808 143 72 0.503496503496504 0.0105757931844888
TF TF:M06948_1 Factor: Sp2; motif: TGGGCGCGCCCA; match class: 1 0.0301098119657865 6205 117 57 0.487179487179487 0.00918614020950846
TF TF:M03896 Factor: EGR1; motif: NACGCCCACGCANW 0.0301098119657865 6129 88 45 0.511363636363636 0.00734214390602056
TF TF:M06463 Factor: ZNF595; motif: NGKGGCGGCMGM 0.0319053591181095 113 124 6 0.0483870967741935 0.0530973451327434
TF TF:M07354_1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 0.0350969811997484 3561 62 24 0.387096774193548 0.0067396798652064
TF TF:M01219_1 Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1 0.0350969811997484 2937 36 15 0.416666666666667 0.00510725229826353
TF TF:M01855 Factor: AHR; motif: CACGCN 0.0350969811997484 8491 81 52 0.641975308641975 0.0061241314332823
TF TF:M01175_1 Factor: CKROX; motif: SCCCTCCCC; match class: 1 0.0387193835325483 2679 121 32 0.264462809917355 0.0119447555057857
TF TF:M00695 Factor: ETF; motif: GVGGMGG 0.0387193835325483 10430 142 97 0.683098591549296 0.00930009587727709
TF TF:M00695_1 Factor: ETF; motif: GVGGMGG; match class: 1 0.0419725907074969 7032 130 67 0.515384615384615 0.00952787258248009
TF TF:M01100_1 Factor: LRF; motif: GGGGKYNNB; match class: 1 0.0486268195371976 2762 36 14 0.388888888888889 0.00506879073135409
TF TF:M12217 Factor: GLIS2; motif: ACCCCCCRCGWNGC 0.0486268195371976 567 89 10 0.112359550561798 0.017636684303351
TF TF:M10086 Factor: TAFII250; motif: RARRWGGCGGMGGNGR 0.0486268195371976 9262 116 74 0.637931034482759 0.00798963506801987
TF TF:M00932 Factor: Sp1; motif: NNGGGGCGGGGNN 0.0486268195371976 10419 134 91 0.67910447761194 0.00873404357423937
TF TF:M06948 Factor: Sp2; motif: TGGGCGCGCCCA 0.0486268195371976 8864 140 84 0.6 0.00947653429602888
TF TF:M10086_1 Factor: TAFII250; motif: RARRWGGCGGMGGNGR; match class: 1 0.0486268195371976 4153 77 30 0.38961038961039 0.00722369371538647
TF TF:M04110_1 Factor: RUNX3; motif: NRACCGCANWAACCRCAN; match class: 1 0.0486268195371976 3764 115 38 0.330434782608696 0.0100956429330499
TF TF:M12345_1 Factor: Zbtb37; motif: NYACCGCRNTCACCGCR; match class: 1 0.0486268195371976 1688 44 12 0.272727272727273 0.00710900473933649
TF TF:M00736 Factor: E2F-1:DP-1; motif: TTTCSCGC 0.0486268195371976 10390 130 89 0.684615384615385 0.00856592877767084
TF TF:M08878 Factor: EGR; motif: CGCCCCCGCNN 0.0486268195371976 7483 39 26 0.666666666666667 0.00347454229587064
TF TF:M00737 Factor: E2F-1:DP-2; motif: TTTSSCGC 0.0486268195371976 8771 126 76 0.603174603174603 0.00866491848135902
TF TF:M01857_1 Factor: AP-2alpha; motif: NGCCYSNNGSN; match class: 1 0.0486268195371976 4616 61 27 0.442622950819672 0.00584922010398614
TF TF:M00189_1 Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 0.0486268195371976 6093 144 65 0.451388888888889 0.0106679796487773
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.0492179366561649 10281 134 90 0.671641791044776 0.00875401225561716
TF TF:M00244 Factor: NGFI-C; motif: WTGCGTGGGYGG 0.0492179366561649 6184 62 33 0.532258064516129 0.00533635187580854

pEpi05 transcription factor target enrichment of top program genes

TF enrichment of pEpi05
Possible regulators of activation of pEpi05 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.