pEpiTp08 program activity among Epithelial cells

Activation of pEpiTp08
pEpiTp08 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp08 by different cell subtypes
pEpiTp08 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp08 top program genes

Top genes of pEpiTp08 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp08 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp08
pEpiTp08 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0022600 digestive system process 0.0176935103237252 102 33 4 0.121212121212121 0.0392156862745098
GO:BP GO:0007586 digestion 0.046867707221129 141 33 4 0.121212121212121 0.0283687943262411
GO:CC GO:0062023 collagen-containing extracellular matrix 0.00033247840704336 421 28 7 0.25 0.0166270783847981
GO:CC GO:0031012 extracellular matrix 0.000746492083225047 562 28 7 0.25 0.0124555160142349
GO:CC GO:0030312 external encapsulating structure 0.000746492083225047 563 28 7 0.25 0.0124333925399645
GO:CC GO:0005576 extracellular region 0.0244101467700451 4567 59 26 0.440677966101695 0.00569301510838625
GO:MF GO:0048018 receptor ligand activity 0.0276750080993787 494 47 6 0.127659574468085 0.0121457489878543
GO:MF GO:0001664 G protein-coupled receptor binding 0.0276750080993787 292 36 4 0.111111111111111 0.0136986301369863
GO:MF GO:0005201 extracellular matrix structural constituent 0.0276750080993787 171 55 4 0.0727272727272727 0.0233918128654971
GO:MF GO:0030020 extracellular matrix structural constituent conferring tensile strength 0.0276750080993787 41 55 3 0.0545454545454545 0.0731707317073171
GO:MF GO:0030545 receptor regulator activity 0.0276750080993787 545 47 6 0.127659574468085 0.0110091743119266
GO:MF GO:0030546 signaling receptor activator activity 0.0276750080993787 501 47 6 0.127659574468085 0.0119760479041916
GO:MF GO:1901681 sulfur compound binding 0.0446120009756115 264 51 4 0.0784313725490196 0.0151515151515152

pEpiTp08 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp08
Possible regulators of activation of pEpiTp08 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.