pEpi26 program activity among Epithelial cells

Activation of pEpi26
pEpi26 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi26 by different cell subtypes
pEpi26 gene program activation among cells of different subtypes (Epithelial cells).

pEpi26 top program genes

Top genes of pEpi26 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi26 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi26
pEpi26 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:178 Respiratory chain complex I (holoenzyme), mitochondrial 0.00197556540662708 44 23 4 0.173913043478261 0.0909090909090909
GO:BP GO:0006119 oxidative phosphorylation 8.68878594205172e-19 151 31 14 0.451612903225806 0.0927152317880795
GO:BP GO:0046034 ATP metabolic process 2.29539249314567e-16 314 31 15 0.483870967741935 0.0477707006369427
GO:BP GO:0022900 electron transport chain 2.29539249314567e-16 180 23 12 0.521739130434783 0.0666666666666667
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 1.11485362130317e-15 99 31 11 0.354838709677419 0.111111111111111
GO:BP GO:0042773 ATP synthesis coupled electron transport 1.11485362130317e-15 100 31 11 0.354838709677419 0.11
GO:BP GO:0006091 generation of precursor metabolites and energy 1.51849000892636e-15 538 24 15 0.625 0.0278810408921933
GO:BP GO:0022904 respiratory electron transport chain 4.79469196499953e-15 117 31 11 0.354838709677419 0.094017094017094
GO:BP GO:0045333 cellular respiration 1.09558162004944e-12 192 31 11 0.354838709677419 0.0572916666666667
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 8.48037066990278e-11 289 23 10 0.434782608695652 0.0346020761245675
GO:BP GO:1902600 proton transmembrane transport 1.55302591858638e-08 157 31 8 0.258064516129032 0.0509554140127389
GO:BP GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 2.43589559028728e-06 20 31 4 0.129032258064516 0.2
GO:BP GO:0019646 aerobic electron transport chain 2.43589559028728e-06 20 31 4 0.129032258064516 0.2
GO:BP GO:0007005 mitochondrion organization 9.53636211404202e-06 561 29 9 0.310344827586207 0.0160427807486631
GO:BP GO:0055114 obsolete oxidation-reduction process 9.7622846709185e-06 745 23 9 0.391304347826087 0.0120805369127517
GO:BP GO:0009060 aerobic respiration 2.15044832459012e-05 89 31 5 0.161290322580645 0.0561797752808989
GO:BP GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 2.15044832459012e-05 13 21 3 0.142857142857143 0.230769230769231
GO:BP GO:0016310 phosphorylation 3.02864992179742e-05 2138 24 13 0.541666666666667 0.00608044901777362
GO:BP GO:0006120 mitochondrial electron transport, NADH to ubiquinone 3.38041581374858e-05 56 23 4 0.173913043478261 0.0714285714285714
GO:BP GO:0032981 mitochondrial respiratory chain complex I assembly 5.99103667719607e-05 67 23 4 0.173913043478261 0.0597014925373134
GO:BP GO:0007007 inner mitochondrial membrane organization 5.99103667719607e-05 56 27 4 0.148148148148148 0.0714285714285714
GO:BP GO:0010257 NADH dehydrogenase complex assembly 5.99103667719607e-05 67 23 4 0.173913043478261 0.0597014925373134
GO:BP GO:0042776 mitochondrial ATP synthesis coupled proton transport 0.000183725579654595 25 24 3 0.125 0.12
GO:BP GO:0006839 mitochondrial transport 0.000188233948695886 284 29 6 0.206896551724138 0.0211267605633803
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.000218247673658946 3087 24 14 0.583333333333333 0.00453514739229025
GO:BP GO:0006793 phosphorus metabolic process 0.000232894336467491 3114 24 14 0.583333333333333 0.00449582530507386
GO:BP GO:0015985 energy coupled proton transport, down electrochemical gradient 0.00025371387047672 30 24 3 0.125 0.1
GO:BP GO:0033108 mitochondrial respiratory chain complex assembly 0.00025371387047672 103 23 4 0.173913043478261 0.0388349514563107
GO:BP GO:0015986 ATP synthesis coupled proton transport 0.00025371387047672 30 24 3 0.125 0.1
GO:BP GO:0042407 cristae formation 0.000393187529087736 35 24 3 0.125 0.0857142857142857
GO:BP GO:0098662 inorganic cation transmembrane transport 0.00123354887458832 794 31 8 0.258064516129032 0.0100755667506297
GO:BP GO:0006754 ATP biosynthetic process 0.00178924129046314 59 24 3 0.125 0.0508474576271186
GO:BP GO:0007006 mitochondrial membrane organization 0.00192106512682858 151 27 4 0.148148148148148 0.0264900662251656
GO:BP GO:0098660 inorganic ion transmembrane transport 0.00237420023295814 883 31 8 0.258064516129032 0.00906002265005663
GO:BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process 0.00272082717161237 70 24 3 0.125 0.0428571428571429
GO:BP GO:0009145 purine nucleoside triphosphate biosynthetic process 0.00275729892948722 71 24 3 0.125 0.0422535211267606
GO:BP GO:0098655 cation transmembrane transport 0.0027695246240327 914 31 8 0.258064516129032 0.0087527352297593
GO:BP GO:0006812 cation transport 0.0029483573604195 1197 31 9 0.290322580645161 0.0075187969924812
GO:BP GO:0009201 ribonucleoside triphosphate biosynthetic process 0.00311015776590043 76 24 3 0.125 0.0394736842105263
GO:BP GO:0009205 purine ribonucleoside triphosphate metabolic process 0.00407893893872635 84 24 3 0.125 0.0357142857142857
GO:BP GO:0009142 nucleoside triphosphate biosynthetic process 0.00441250532070392 87 24 3 0.125 0.0344827586206897
GO:BP GO:0009144 purine nucleoside triphosphate metabolic process 0.00475891570097911 90 24 3 0.125 0.0333333333333333
GO:BP GO:0009199 ribonucleoside triphosphate metabolic process 0.0047998095140731 91 24 3 0.125 0.032967032967033
GO:BP GO:0009141 nucleoside triphosphate metabolic process 0.0082863255541335 113 24 3 0.125 0.0265486725663717
GO:BP GO:1990542 mitochondrial transmembrane transport 0.00832198023377059 114 24 3 0.125 0.0263157894736842
GO:BP GO:0009152 purine ribonucleotide biosynthetic process 0.0246045093413793 179 24 3 0.125 0.0167597765363128
GO:BP GO:0034220 ion transmembrane transport 0.0250891994177065 1397 24 7 0.291666666666667 0.00501073729420186
GO:BP GO:0009260 ribonucleotide biosynthetic process 0.0275824261961394 192 24 3 0.125 0.015625
GO:BP GO:0009150 purine ribonucleotide metabolic process 0.0275824261961394 414 24 4 0.166666666666667 0.00966183574879227
GO:BP GO:0140053 mitochondrial gene expression 0.0285022143132445 167 28 3 0.107142857142857 0.0179640718562874
GO:BP GO:0046390 ribose phosphate biosynthetic process 0.0287450712655825 199 24 3 0.125 0.0150753768844221
GO:BP GO:0032368 regulation of lipid transport 0.0291138188639128 167 29 3 0.103448275862069 0.0179640718562874
GO:BP GO:0009259 ribonucleotide metabolic process 0.0291138188639128 431 24 4 0.166666666666667 0.00928074245939675
GO:BP GO:0006164 purine nucleotide biosynthetic process 0.0291138188639128 202 24 3 0.125 0.0148514851485149
GO:BP GO:0019693 ribose phosphate metabolic process 0.029632849349573 441 24 4 0.166666666666667 0.0090702947845805
GO:BP GO:0006163 purine nucleotide metabolic process 0.03118891511917 450 24 4 0.166666666666667 0.00888888888888889
GO:BP GO:0072522 purine-containing compound biosynthetic process 0.03118891511917 213 24 3 0.125 0.0140845070422535
GO:BP GO:0072521 purine-containing compound metabolic process 0.0357398496344648 473 24 4 0.166666666666667 0.00845665961945032
GO:BP GO:1905952 regulation of lipid localization 0.0410102118311406 201 29 3 0.103448275862069 0.0149253731343284
GO:BP GO:0055085 transmembrane transport 0.0419688710864062 1635 24 7 0.291666666666667 0.00428134556574924
GO:BP GO:0009165 nucleotide biosynthetic process 0.0460042970016042 269 24 3 0.125 0.0111524163568773
GO:BP GO:0009117 nucleotide metabolic process 0.0460042970016042 544 24 4 0.166666666666667 0.00735294117647059
GO:BP GO:1901293 nucleoside phosphate biosynthetic process 0.0465949033834123 273 24 3 0.125 0.010989010989011
GO:BP GO:0006753 nucleoside phosphate metabolic process 0.0484082101577311 555 24 4 0.166666666666667 0.00720720720720721
GO:CC GO:0005743 mitochondrial inner membrane 1.1153082028971e-20 503 31 19 0.612903225806452 0.0377733598409543
GO:CC GO:0098798 mitochondrial protein-containing complex 2.99948509256918e-20 270 31 16 0.516129032258065 0.0592592592592593
GO:CC GO:0019866 organelle inner membrane 3.27170703315675e-20 564 31 19 0.612903225806452 0.0336879432624113
GO:CC GO:0031966 mitochondrial membrane 1.14657423016948e-19 746 31 20 0.645161290322581 0.0268096514745308
GO:CC GO:0005740 mitochondrial envelope 3.39905434741946e-19 797 31 20 0.645161290322581 0.0250941028858218
GO:CC GO:0098800 inner mitochondrial membrane protein complex 7.82042816869262e-19 146 31 13 0.419354838709677 0.089041095890411
GO:CC GO:0070469 respirasome 8.32978572694602e-19 103 31 12 0.387096774193548 0.116504854368932
GO:CC GO:0005746 mitochondrial respirasome 1.66380779394566e-17 89 31 11 0.354838709677419 0.123595505617978
GO:CC GO:0005739 mitochondrion 2.82141945875842e-17 1673 31 23 0.741935483870968 0.013747758517633
GO:CC GO:0031967 organelle envelope 8.3883891329922e-17 1237 32 21 0.65625 0.0169765561843169
GO:CC GO:0031975 envelope 8.3883891329922e-17 1237 32 21 0.65625 0.0169765561843169
GO:CC GO:0098803 respiratory chain complex 9.6942150444805e-16 86 31 10 0.32258064516129 0.116279069767442
GO:CC GO:0070069 cytochrome complex 1.51095582696093e-10 34 31 6 0.193548387096774 0.176470588235294
GO:CC GO:0098796 membrane protein complex 9.90085959209145e-09 1322 24 13 0.541666666666667 0.00983358547655068
GO:CC GO:0031090 organelle membrane 2.42657073578206e-08 3612 33 22 0.666666666666667 0.00609080841638981
GO:CC GO:0005751 mitochondrial respiratory chain complex IV 2.42657073578206e-08 12 31 4 0.129032258064516 0.333333333333333
GO:CC GO:1990204 oxidoreductase complex 2.82877863824671e-08 113 23 6 0.260869565217391 0.0530973451327434
GO:CC GO:0045277 respiratory chain complex IV 2.51635161713867e-07 21 31 4 0.129032258064516 0.19047619047619
GO:CC GO:0030964 NADH dehydrogenase complex 2.48843877675522e-06 51 23 4 0.173913043478261 0.0784313725490196
GO:CC GO:0045271 respiratory chain complex I 2.48843877675522e-06 51 23 4 0.173913043478261 0.0784313725490196
GO:CC GO:0005747 mitochondrial respiratory chain complex I 2.48843877675522e-06 51 23 4 0.173913043478261 0.0784313725490196
GO:CC GO:0005737 cytoplasm 0.000265123765181043 11911 33 31 0.939393939393939 0.00260263621862144
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.000422954691709455 11296 33 30 0.909090909090909 0.00265580736543909
GO:CC GO:0032991 protein-containing complex 0.000646795509788587 5548 28 18 0.642857142857143 0.00324441240086518
GO:CC GO:0043229 intracellular organelle 0.00392367517681546 12491 33 30 0.909090909090909 0.00240172924505644
GO:CC GO:0043227 membrane-bounded organelle 0.0075284020476838 12858 33 30 0.909090909090909 0.00233317778814746
GO:CC GO:0016020 membrane 0.0142482386025289 9838 33 25 0.757575757575758 0.00254116690384224
GO:CC GO:1902494 catalytic complex 0.0187393462177092 1441 23 6 0.260869565217391 0.00416377515614157
GO:CC GO:0016021 integral component of membrane 0.0218796294851812 5711 33 17 0.515151515151515 0.00297671160917528
GO:CC GO:0031224 intrinsic component of membrane 0.02814463383183 5868 33 17 0.515151515151515 0.00289706884798909
GO:CC GO:0043226 organelle 0.0346014315397755 14008 33 30 0.909090909090909 0.00214163335237007
GO:CC GO:0005622 intracellular anatomical structure 0.0346014315397755 14790 33 31 0.939393939393939 0.00209601081812035
GO:MF GO:0009055 electron transfer activity 5.81678354360433e-18 148 23 12 0.521739130434783 0.0810810810810811
GO:MF GO:0015002 heme-copper terminal oxidase activity 1.07482796761838e-10 27 31 6 0.193548387096774 0.222222222222222
GO:MF GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 1.07482796761838e-10 27 31 6 0.193548387096774 0.222222222222222
GO:MF GO:0004129 cytochrome-c oxidase activity 1.07482796761838e-10 27 31 6 0.193548387096774 0.222222222222222
GO:MF GO:0016675 oxidoreductase activity, acting on a heme group of donors 1.09311362332288e-10 28 31 6 0.193548387096774 0.214285714285714
GO:MF GO:0015078 proton transmembrane transporter activity 3.78476289386938e-10 125 31 8 0.258064516129032 0.064
GO:MF GO:0016491 oxidoreductase activity 3.78476289386938e-10 771 23 12 0.521739130434783 0.0155642023346304
GO:MF GO:0008121 ubiquinol-cytochrome-c reductase activity 1.01694064272512e-06 8 21 3 0.142857142857143 0.375
GO:MF GO:0008137 NADH dehydrogenase (ubiquinone) activity 2.98112716899509e-06 46 23 4 0.173913043478261 0.0869565217391304
GO:MF GO:0050136 NADH dehydrogenase (quinone) activity 2.98112716899509e-06 46 23 4 0.173913043478261 0.0869565217391304
GO:MF GO:0003954 NADH dehydrogenase activity 2.98112716899509e-06 46 23 4 0.173913043478261 0.0869565217391304
GO:MF GO:0003955 NAD(P)H dehydrogenase (quinone) activity 3.53941873068597e-06 49 23 4 0.173913043478261 0.0816326530612245
GO:MF GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 7.96877365714929e-06 61 23 4 0.173913043478261 0.0655737704918033
GO:MF GO:0022890 inorganic cation transmembrane transporter activity 3.37785403862103e-05 591 31 8 0.258064516129032 0.0135363790186125
GO:MF GO:0008324 cation transmembrane transporter activity 5.60053535216566e-05 639 31 8 0.258064516129032 0.0125195618153365
GO:MF GO:0016651 oxidoreductase activity, acting on NAD(P)H 6.16713333599657e-05 107 23 4 0.173913043478261 0.0373831775700935
GO:MF GO:0005215 transporter activity 9.2494561629503e-05 1185 31 10 0.32258064516129 0.00843881856540084
GO:MF GO:0015318 inorganic molecular entity transmembrane transporter activity 0.000310928118094287 831 31 8 0.258064516129032 0.00962695547533093
GO:MF GO:0015075 ion transmembrane transporter activity 0.000788315913166969 956 31 8 0.258064516129032 0.00836820083682008
GO:MF GO:0022857 transmembrane transporter activity 0.00167842938595404 1075 31 8 0.258064516129032 0.00744186046511628
GO:MF GO:0003824 catalytic activity 0.0245823245049798 5896 24 14 0.583333333333333 0.00237449118046133
HPA HPA:0400053 rectum; glandular cells[High] 0.00286499040843527 2687 23 16 0.695652173913043 0.00595459620394492
HPA HPA:0130053 colon; glandular cells[High] 0.0034746241264964 2538 23 15 0.652173913043478 0.00591016548463357
HPA HPA:0030053 appendix; glandular cells[High] 0.0034746241264964 1986 31 16 0.516129032258065 0.0080563947633434
HPA HPA:0241103 heart muscle; cardiomyocytes[High] 0.00368840657347942 1113 23 10 0.434782608695652 0.00898472596585804
HPA HPA:0430053 seminal vesicle; glandular cells[High] 0.00379971296791072 1410 23 11 0.478260869565217 0.00780141843971631
HPA HPA:0550053 stomach 2; glandular cells[High] 0.00960850325277629 2350 33 17 0.515151515151515 0.00723404255319149
HPA HPA:0290403 liver; hepatocytes[High] 0.0108623460249021 839 23 8 0.347826086956522 0.00953516090584029
HPA HPA:0360053 parathyroid gland; glandular cells[High] 0.0112961746993412 1486 18 9 0.5 0.00605652759084791
HPA HPA:0100213 cerebral cortex; neuropil[High] 0.0149055107481329 400 18 5 0.277777777777778 0.0125
HPA HPA:0480053 small intestine; glandular cells[High] 0.0427421187375311 2723 28 15 0.535714285714286 0.00550863018729343
KEGG KEGG:00190 Oxidative phosphorylation 1.91833739975281e-16 133 24 13 0.541666666666667 0.0977443609022556
KEGG KEGG:05415 Diabetic cardiomyopathy 2.64465559310803e-14 203 24 13 0.541666666666667 0.0640394088669951
KEGG KEGG:04714 Thermogenesis 1.01247906589726e-13 232 24 13 0.541666666666667 0.0560344827586207
KEGG KEGG:05012 Parkinson disease 1.90693047571589e-13 249 24 13 0.541666666666667 0.0522088353413655
KEGG KEGG:04932 Non-alcoholic fatty liver disease 3.41182614651125e-13 150 23 11 0.478260869565217 0.0733333333333333
KEGG KEGG:05020 Prion disease 4.19192403038047e-13 273 24 13 0.541666666666667 0.0476190476190476
KEGG KEGG:05014 Amyotrophic lateral sclerosis 4.99410588634326e-13 363 24 14 0.583333333333333 0.0385674931129477
KEGG KEGG:05016 Huntington disease 1.3696443802197e-12 306 24 13 0.541666666666667 0.042483660130719
KEGG KEGG:05010 Alzheimer disease 1.33506498660669e-11 369 24 13 0.541666666666667 0.035230352303523
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 2.91510818313064e-10 475 24 13 0.541666666666667 0.0273684210526316
KEGG KEGG:04260 Cardiac muscle contraction 1.81318355956008e-09 87 31 8 0.258064516129032 0.0919540229885057
KEGG KEGG:01100 Metabolic pathways 0.00018100169709288 1490 24 13 0.541666666666667 0.0087248322147651
KEGG KEGG:04723 Retrograde endocannabinoid signaling 0.00128099196328676 148 23 4 0.173913043478261 0.027027027027027
REAC REAC:R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 4.18767665855766e-16 124 31 13 0.419354838709677 0.104838709677419
REAC REAC:R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 1.77790967614935e-14 174 24 12 0.5 0.0689655172413793
REAC REAC:R-HSA-611105 Respiratory electron transport 4.29746929293086e-14 100 31 11 0.354838709677419 0.11
REAC REAC:R-HSA-5628897 TP53 Regulates Metabolic Genes 2.35887867116065e-05 83 12 4 0.333333333333333 0.0481927710843374
REAC REAC:R-HSA-6799198 Complex I biogenesis 6.10731285713973e-05 55 23 4 0.173913043478261 0.0727272727272727
REAC REAC:R-HSA-1430728 Metabolism 0.000301796673575087 2070 24 14 0.583333333333333 0.00676328502415459
REAC REAC:R-HSA-3700989 Transcriptional Regulation by TP53 0.00412022642830148 360 12 4 0.333333333333333 0.0111111111111111
REAC REAC:R-HSA-1268020 Mitochondrial protein import 0.00412022642830148 65 27 3 0.111111111111111 0.0461538461538462
REAC REAC:R-HSA-9609507 Protein localization 0.027698062514398 158 27 3 0.111111111111111 0.0189873417721519
TF TF:M04456 Factor: ESRRA; motif: NTCAAGGTCAN 0.0216624378072515 1559 30 10 0.333333333333333 0.0064143681847338
TF TF:M03924_1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 0.0216624378072515 3700 28 15 0.535714285714286 0.00405405405405405
TF TF:M09886 Factor: COUP-TF1; motif: GRGGKSARAGGTCAGNG 0.0216624378072515 5888 33 21 0.636363636363636 0.00356657608695652
TF TF:M11832 Factor: ERR1; motif: NNSAAGGTCRN 0.0216624378072515 1763 30 11 0.366666666666667 0.00623936471922859
TF TF:M11824 Factor: SF-1; motif: NNCAAGGNCRN 0.0216624378072515 1530 30 10 0.333333333333333 0.0065359477124183
TF TF:M03802 Factor: SF-1; motif: NYCAAGGYCANNNN 0.0216624378072515 2108 32 12 0.375 0.00569259962049336
TF TF:M07360 Factor: LRH-1; motif: NNNYCAAGGYCAN 0.0216624378072515 1554 30 10 0.333333333333333 0.00643500643500643
TF TF:M11829 Factor: LRH-1; motif: NTCAAGGTCAN 0.0216624378072515 2181 30 12 0.4 0.00550206327372765
TF TF:M11826 Factor: LRH-1; motif: NTCAAGGTCRN 0.0216624378072515 2199 30 12 0.4 0.00545702592087312
TF TF:M10017_1 Factor: LRH-1; motif: NNYCAAGGYCA; match class: 1 0.0216624378072515 269 11 4 0.363636363636364 0.0148698884758364
TF TF:M04873 Factor: ERR1; motif: NTGACCTTGRNN 0.0216624378072515 3166 33 16 0.484848484848485 0.00505369551484523
TF TF:M01132 Factor: SF-1; motif: TGACCTTGN 0.0216624378072515 1534 30 10 0.333333333333333 0.00651890482398957
TF TF:M04714_1 Factor: Elf-1; motif: ACTTCCGGG; match class: 1 0.0216624378072515 2659 19 10 0.526315789473684 0.00376081233546446
TF TF:M00727 Factor: SF-1; motif: TGACCTTG 0.0216624378072515 2320 30 12 0.4 0.00517241379310345
TF TF:M02000 Factor: ERR3; motif: CAAGGTCA 0.0216624378072515 2320 30 12 0.4 0.00517241379310345
TF TF:M02055_1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 0.0216624378072515 2176 19 9 0.473684210526316 0.00413602941176471
TF TF:M01214_1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 0.0216624378072515 2176 19 9 0.473684210526316 0.00413602941176471
TF TF:M09605_1 Factor: Elf-1; motif: NAANCMGGAAGTGN; match class: 1 0.0216624378072515 1306 28 9 0.321428571428571 0.00689127105666156
TF TF:M10084_1 Factor: SF-1; motif: NYYCAAGGYCA; match class: 1 0.0220000694025814 552 27 6 0.222222222222222 0.0108695652173913
TF TF:M11389 Factor: elf5; motif: GAMCCGGAAGTN 0.0230528049433389 1308 31 9 0.290322580645161 0.00688073394495413
TF TF:M02066_1 Factor: PEA3; motif: RCCGGAAGYN; match class: 1 0.0230528049433389 2283 19 9 0.473684210526316 0.00394218134034166
TF TF:M08232_1 Factor: Elk-1:TEF; motif: RCCGGAAGTTACGTAAN; match class: 1 0.0230528049433389 1294 9 5 0.555555555555556 0.00386398763523957
TF TF:M02065_1 Factor: ER81; motif: RCCGGAARYN; match class: 1 0.0230528049433389 6749 23 17 0.739130434782609 0.00251889168765743
TF TF:M10017 Factor: LRH-1; motif: NNYCAAGGYCA 0.0230528049433389 2629 32 13 0.40625 0.00494484594903005
TF TF:M08018 Factor: RARA; motif: GAGGTCAAAAGGTCAAKK 0.0230528049433389 4730 27 16 0.592592592592593 0.00338266384778013
TF TF:M07402 Factor: ESRRA; motif: YCAAGGTCACN 0.0230528049433389 1698 30 10 0.333333333333333 0.00588928150765607
TF TF:M11425_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.0230528049433389 2330 19 9 0.473684210526316 0.00386266094420601
TF TF:M11432 Factor: Elk-1; motif: NACMGGAAGTN 0.0230528049433389 6140 33 21 0.636363636363636 0.00342019543973941
TF TF:M11833_1 Factor: ERR1; motif: NNCAAGGTCAN; match class: 1 0.0241904319557233 76 27 3 0.111111111111111 0.0394736842105263
TF TF:M03982_1 Factor: ETV4; motif: ACCGGAAGTN; match class: 1 0.0241904319557233 2009 31 11 0.354838709677419 0.00547536087605774
TF TF:M11452 Factor: Elf-1; motif: NANGCGGAAGTR 0.0244848533191908 6276 33 21 0.636363636363636 0.00334608030592734
TF TF:M02063_1 Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 0.0244848533191908 2396 19 9 0.473684210526316 0.00375626043405676
TF TF:M11842 Factor: ER-alpha; motif: NAGGTCAYSGYGACCTN 0.0244848533191908 4035 26 14 0.538461538461538 0.00346964064436183
TF TF:M08759_1 Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 0.0244848533191908 2915 23 11 0.478260869565217 0.00377358490566038
TF TF:M11825 Factor: SF-1; motif: NNCAAGGTCAN 0.0244848533191908 1760 30 10 0.333333333333333 0.00568181818181818
TF TF:M08913_1 Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 0.0252418266648673 3055 19 10 0.526315789473684 0.00327332242225859
TF TF:M11834_1 Factor: ERR1; motif: NTCAAGGTCAN; match class: 1 0.026553305183679 84 27 3 0.111111111111111 0.0357142857142857
TF TF:M01165_1 Factor: Elk-1; motif: RACCGGAAGTR; match class: 1 0.0267348645680498 2185 21 9 0.428571428571429 0.00411899313501144
TF TF:M11839_1 Factor: ERR3; motif: NNSAAGGTCAN; match class: 1 0.028797204756294 88 27 3 0.111111111111111 0.0340909090909091
TF TF:M00025_1 Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 0.028797204756294 4639 12 9 0.75 0.00194007329165768
TF TF:M08369_1 Factor: HOXD12:PEA3; motif: RCCGGAAGTAATAAAM; match class: 1 0.0291813716940759 657 19 5 0.263157894736842 0.0076103500761035
TF TF:M09935 Factor: GABP-alpha; motif: NNNRCCGGAAGTGN 0.0291813716940759 4420 28 15 0.535714285714286 0.00339366515837104
TF TF:M09904_1 Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 0.0291813716940759 2743 29 12 0.413793103448276 0.004374772147284
TF TF:M11394 Factor: Erg; motif: NACMGGAARTN 0.0291813716940759 4051 33 16 0.484848484848485 0.00394964206368798
TF TF:M01132_1 Factor: SF-1; motif: TGACCTTGN; match class: 1 0.0291813716940759 97 27 3 0.111111111111111 0.0309278350515464
TF TF:M04456_1 Factor: ESRRA; motif: NTCAAGGTCAN; match class: 1 0.0291813716940759 100 27 3 0.111111111111111 0.03
TF TF:M08423_1 Factor: TEF-3:ER81; motif: ACCGGAAATRCC; match class: 1 0.0291813716940759 654 19 5 0.263157894736842 0.00764525993883792
TF TF:M08953 Factor: FXR; motif: NAGGTCAWNKN 0.0291813716940759 4828 31 17 0.548387096774194 0.00352112676056338
TF TF:M11447_1 Factor: Elf-1; motif: NAMCCGGAAGTN; match class: 1 0.0291813716940759 2593 19 9 0.473684210526316 0.00347088314693405
TF TF:M09900 Factor: Elf-1; motif: NNANCCGGAAGTGS 0.0291813716940759 5219 20 13 0.65 0.00249089863958613
TF TF:M09918_1 Factor: Pet-1; motif: GCNGGAAGYG; match class: 1 0.0291813716940759 7159 23 17 0.739130434782609 0.00237463332867719
TF TF:M08016 Factor: COUP-TF1; motif: NARAGGTCANNNG 0.0291813716940759 1369 6 4 0.666666666666667 0.0029218407596786
TF TF:M01036 Factor: COUPTF; motif: NNNNNTGACCYTTGNMCNYNGMN 0.0291813716940759 3807 14 9 0.642857142857143 0.00236406619385343
TF TF:M02073_1 Factor: Fli-1; motif: ACCGGAAGYN; match class: 1 0.0291813716940759 1488 31 9 0.290322580645161 0.00604838709677419
TF TF:M02093 Factor: ERR1; motif: CAAGGTCAMNN 0.0291813716940759 1395 6 4 0.666666666666667 0.0028673835125448
TF TF:M11824_1 Factor: SF-1; motif: NNCAAGGNCRN; match class: 1 0.0291813716940759 97 27 3 0.111111111111111 0.0309278350515464
TF TF:M11601_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.0296917864702518 11053 30 26 0.866666666666667 0.00235230254229621
TF TF:M02064 Factor: c-ets-2; motif: ACCGGAWRTN 0.0296917864702518 10939 33 28 0.848484848484849 0.00255964896242801
TF TF:M11451_1 Factor: Elf-1; motif: NANCCGGAAGTN; match class: 1 0.0299523466844467 2112 23 9 0.391304347826087 0.00426136363636364
TF TF:M11428_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.0327088595430307 2146 23 9 0.391304347826087 0.00419384902143523
TF TF:M11347 Factor: MafG; motif: NTGCTGAYGTCAGCAN 0.0327088595430307 1478 3 3 1 0.0020297699594046
TF TF:M08963_1 Factor: NR1B1; motif: RAGGTCA; match class: 1 0.0334831547769604 869 33 7 0.212121212121212 0.00805523590333717
TF TF:M02098 Factor: LRH-1; motif: NNYCAAGGYYN 0.0334831547769604 3000 32 13 0.40625 0.00433333333333333
TF TF:M11835_1 Factor: ERR1; motif: NNCAAGGTCAN; match class: 1 0.0334831547769604 111 27 3 0.111111111111111 0.027027027027027
TF TF:M07402_1 Factor: ESRRA; motif: YCAAGGTCACN; match class: 1 0.0334831547769604 114 27 3 0.111111111111111 0.0263157894736842
TF TF:M11379 Factor: ESE-1; motif: ACCCGGAAGTRNNNNNNNNWWWW 0.0334831547769604 3200 20 10 0.5 0.003125
TF TF:M08968_1 Factor: RXR-ALPHA; motif: RAGGTCA; match class: 1 0.0334831547769604 869 33 7 0.212121212121212 0.00805523590333717
TF TF:M03542_1 Factor: COUP-TF1; motif: TGACCTY; match class: 1 0.0334831547769604 869 33 7 0.212121212121212 0.00805523590333717
TF TF:M09901 Factor: nerf; motif: NNNCCGGAAGTGN 0.0334831547769604 5352 20 13 0.65 0.00242899850523169
TF TF:M04698 Factor: GABP-alpha; motif: CACTTCCGG 0.0334831547769604 3196 20 10 0.5 0.00312891113892365
TF TF:M03969 Factor: ELF5; motif: ANSMGGAAGTN 0.0335465873594732 3339 33 14 0.424242424242424 0.00419287211740042
TF TF:M02054 Factor: ELF2; motif: CCCGGAARYN 0.0337284324084604 3066 28 12 0.428571428571429 0.00391389432485323
TF TF:M03966_1 Factor: ELF1; motif: AACCCGGAAGTR; match class: 1 0.0337867731190888 1577 31 9 0.290322580645161 0.00570703868103995
TF TF:M11422 Factor: Erm; motif: NRCMGGAAGTN 0.034939627285433 4669 20 12 0.6 0.00257014349967873
TF TF:M11384 Factor: ESE-1; motif: ACCCGGAAGTRNNNNNNNWWWWW 0.0356346081866362 3272 20 10 0.5 0.00305623471882641
TF TF:M12075_1 Factor: ZNF342; motif: TRSTGGACRNT; match class: 1 0.0359592404007357 1319 7 4 0.571428571428571 0.00303260045489007
TF TF:M11832_1 Factor: ERR1; motif: NNSAAGGTCRN; match class: 1 0.0359592404007357 121 27 3 0.111111111111111 0.0247933884297521
TF TF:M11825_1 Factor: SF-1; motif: NNCAAGGTCAN; match class: 1 0.0363864796876091 122 27 3 0.111111111111111 0.0245901639344262
TF TF:M11419_1 Factor: ER81; motif: NNCCGGAWGYN; match class: 1 0.0372938375380086 1427 11 5 0.454545454545455 0.00350385423966363
TF TF:M11835 Factor: ERR1; motif: NNCAAGGTCAN 0.0386427962150293 1664 6 4 0.666666666666667 0.00240384615384615
TF TF:M02074_1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 1 0.0393575819714519 1005 9 4 0.444444444444444 0.00398009950248756
TF TF:M11452_1 Factor: Elf-1; motif: NANGCGGAAGTR; match class: 1 0.0393575819714519 1696 19 7 0.368421052631579 0.00412735849056604
TF TF:M02098_1 Factor: LRH-1; motif: NNYCAAGGYYN; match class: 1 0.0397382649994538 333 11 3 0.272727272727273 0.00900900900900901
TF TF:M11435_1 Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 0.0397382649994538 5745 31 18 0.580645161290323 0.0031331592689295
TF TF:M11432_1 Factor: Elk-1; motif: NACMGGAAGTN; match class: 1 0.0397382649994538 1525 21 7 0.333333333333333 0.00459016393442623
TF TF:M04873_1 Factor: ERR1; motif: NTGACCTTGRNN; match class: 1 0.042777012380665 310 27 4 0.148148148148148 0.0129032258064516
TF TF:M09833 Factor: RXRALPHA; motif: CNNTGRCCTYTNN 0.0434155825394937 5363 33 18 0.545454545454545 0.00335633041208279
TF TF:M11477_1 Factor: AP-2beta; motif: NSCCYNRGGSN; match class: 1 0.0434959560018989 6950 33 21 0.636363636363636 0.00302158273381295
TF TF:M09908 Factor: ERR1; motif: NYCAAGGTCANNNNN 0.0439332671652596 1055 30 7 0.233333333333333 0.00663507109004739
TF TF:M01229 Factor: GTF2IRD1-isoform2; motif: GGGATTRNR 0.0439332671652596 15179 27 27 1 0.00177877330522432
TF TF:M10084 Factor: SF-1; motif: NYYCAAGGYCA 0.047363884199789 3986 33 15 0.454545454545455 0.00376317109884596
TF TF:M11437 Factor: SAP-1; motif: NRCCGGAWGYN 0.047363884199789 2788 28 11 0.392857142857143 0.0039454806312769
TF TF:M01752_1 Factor: ERG; motif: ACCGGAART; match class: 1 0.0475345951972717 3705 19 10 0.526315789473684 0.00269905533063428
TF TF:M09737_1 Factor: ZNF644; motif: TCCWGCCTCTSN; match class: 1 0.0480269281577156 1857 6 4 0.666666666666667 0.00215401184706516
TF TF:M11415 Factor: GABP-alpha; motif: NRCCGGAAGTN 0.0480269281577156 3257 18 9 0.5 0.00276327909118821
TF TF:M11418 Factor: ER81; motif: NRCMGGAWGNN 0.0480269281577156 3978 30 14 0.466666666666667 0.00351935646053293
TF TF:M11439 Factor: Net; motif: NRCCGGAAGTN 0.0480269281577156 2568 18 8 0.444444444444444 0.00311526479750779
TF TF:M02059_1 Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 0.0480269281577156 3759 19 10 0.526315789473684 0.00266028198989093
TF TF:M02056_1 Factor: ELF4; motif: NCCGGAARTN; match class: 1 0.0480269281577156 1291 8 4 0.5 0.00309837335398916
TF TF:M03796_1 Factor: MafA; motif: GGTCAGCAGH; match class: 1 0.0480269281577156 681 14 4 0.285714285714286 0.00587371512481645
TF TF:M00930 Factor: Oct-1; motif: TNATTTGCATW 0.0480269281577156 1972 3 3 1 0.00152129817444219
TF TF:M03841_1 Factor: PEBP2beta; motif: TGTGGTY; match class: 1 0.0480269281577156 1963 3 3 1 0.00152827305145186
TF TF:M08461 Factor: Erm:EVX1; motif: NNCGGAAATKR 0.0480269281577156 3396 24 11 0.458333333333333 0.00323910482921084
TF TF:M02067_1 Factor: ER71; motif: ACCGGAARYN; match class: 1 0.0482591415734497 1619 11 5 0.454545454545455 0.00308832612723904
TF TF:M00032_1 Factor: c-Ets-1(p54); motif: NCMGGAWGYN; match class: 1 0.0482591415734497 2161 21 8 0.380952380952381 0.003701989819528
TF TF:M10169_1 Factor: ZNF76; motif: RNNGCMTKCTGGGARNTGTAGT; match class: 1 0.0482591415734497 293 31 4 0.129032258064516 0.0136518771331058
TF TF:M00920 Factor: E2F; motif: NKCGCGCSAAAN 0.0488583474007606 5663 10 8 0.8 0.00141267879215963
TF TF:M02273_1 Factor: NURR1; motif: AAGGTCAC; match class: 1 0.0488583474007606 1998 33 10 0.303030303030303 0.005005005005005
TF TF:M08377_1 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 0.0491078605965592 5051 20 12 0.6 0.00237576717481687
WP WP:WP111 Electron Transport Chain (OXPHOS system in mitochondria) 9.91730772464295e-18 105 24 13 0.541666666666667 0.123809523809524
WP WP:WP4396 Nonalcoholic fatty liver disease 1.86096605305168e-12 159 23 11 0.478260869565217 0.0691823899371069
WP WP:WP4922 Mitochondrial CIV Assembly 1.95226207862943e-08 35 31 6 0.193548387096774 0.171428571428571
WP WP:WP623 Oxidative phosphorylation 4.09944207378221e-06 62 24 5 0.208333333333333 0.0806451612903226
WP WP:WP4921 Mitochondrial CIII assembly 2.80721266626587e-05 16 21 3 0.142857142857143 0.1875
WP WP:WP4324 Mitochondrial complex I assembly model OXPHOS system 4.97101516080817e-05 56 23 4 0.173913043478261 0.0714285714285714

pEpi26 transcription factor target enrichment of top program genes

TF enrichment of pEpi26
Possible regulators of activation of pEpi26 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.