pEpi38 program activity among Epithelial cells

Activation of pEpi38
pEpi38 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi38 by different cell subtypes
pEpi38 gene program activation among cells of different subtypes (Epithelial cells).

pEpi38 top program genes

Top genes of pEpi38 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi38 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi38
pEpi38 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:1142 SMN complex 0.000707842428233959 9 26 3 0.115384615384615 0.333333333333333
CORUM CORUM:835 6S methyltransferase and RG-containing Sm proteins complex 0.000707842428233959 8 26 3 0.115384615384615 0.375
CORUM CORUM:1745 SMN complex 0.00130395542758486 15 26 3 0.115384615384615 0.2
CORUM CORUM:1143 SMN complex 0.00130395542758486 15 26 3 0.115384615384615 0.2
CORUM CORUM:1068 12S U11 snRNP 0.00130395542758486 15 26 3 0.115384615384615 0.2
CORUM CORUM:178 Respiratory chain complex I (holoenzyme), mitochondrial 0.00236359910598039 44 28 4 0.142857142857143 0.0909090909090909
CORUM CORUM:430 18S U11/U12 snRNP 0.00352869837331987 24 26 3 0.115384615384615 0.125
CORUM CORUM:2755 17S U2 snRNP 0.00482471882278285 33 26 3 0.115384615384615 0.0909090909090909
CORUM CORUM:1181 C complex spliceosome 0.00913141686778455 79 29 4 0.137931034482759 0.0506329113924051
CORUM CORUM:351 Spliceosome 0.0414026248298352 141 30 4 0.133333333333333 0.0283687943262411
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 7.93936170412737e-13 99 32 10 0.3125 0.101010101010101
GO:BP GO:0042773 ATP synthesis coupled electron transport 7.93936170412737e-13 100 32 10 0.3125 0.1
GO:BP GO:0022904 respiratory electron transport chain 2.67634962448024e-12 117 32 10 0.3125 0.0854700854700855
GO:BP GO:0006119 oxidative phosphorylation 2.71415134714823e-11 151 32 10 0.3125 0.0662251655629139
GO:BP GO:0022900 electron transport chain 1.28045324358764e-10 180 32 10 0.3125 0.0555555555555556
GO:BP GO:0045333 cellular respiration 2.04030248627186e-10 192 32 10 0.3125 0.0520833333333333
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 3.1703439730235e-10 289 32 11 0.34375 0.0380622837370242
GO:BP GO:0046034 ATP metabolic process 2.00690397211089e-08 314 32 10 0.3125 0.0318471337579618
GO:BP GO:0019646 aerobic electron transport chain 3.10104858211389e-08 20 32 5 0.15625 0.25
GO:BP GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 3.10104858211389e-08 20 32 5 0.15625 0.25
GO:BP GO:0006091 generation of precursor metabolites and energy 1.56839236510865e-07 538 32 11 0.34375 0.0204460966542751
GO:BP GO:0009060 aerobic respiration 1.32804205639795e-06 89 32 6 0.1875 0.0674157303370786
GO:BP GO:0034599 cellular response to oxidative stress 7.61413773695825e-05 316 19 6 0.315789473684211 0.0189873417721519
GO:BP GO:0035722 interleukin-12-mediated signaling pathway 9.91030351376153e-05 47 29 4 0.137931034482759 0.0851063829787234
GO:BP GO:0016310 phosphorylation 9.91030351376153e-05 2138 32 15 0.46875 0.00701590271281572
GO:BP GO:0071349 cellular response to interleukin-12 0.000109705524950751 49 29 4 0.137931034482759 0.0816326530612245
GO:BP GO:0070671 response to interleukin-12 0.000112106795722799 50 29 4 0.137931034482759 0.08
GO:BP GO:0062197 cellular response to chemical stress 0.000127488807056618 365 19 6 0.315789473684211 0.0164383561643836
GO:BP GO:0006120 mitochondrial electron transport, NADH to ubiquinone 0.000137310279888804 56 28 4 0.142857142857143 0.0714285714285714
GO:BP GO:0055114 obsolete oxidation-reduction process 0.000235138336774836 745 31 9 0.290322580645161 0.0120805369127517
GO:BP GO:0098869 cellular oxidant detoxification 0.000248947406805985 100 19 4 0.210526315789474 0.04
GO:BP GO:0080135 regulation of cellular response to stress 0.000377538100372498 725 19 7 0.368421052631579 0.0096551724137931
GO:BP GO:1990748 cellular detoxification 0.000377538100372498 113 19 4 0.210526315789474 0.0353982300884956
GO:BP GO:0006979 response to oxidative stress 0.000392290461486263 466 19 6 0.315789473684211 0.0128755364806867
GO:BP GO:0097237 cellular response to toxic substance 0.000432297398453547 120 19 4 0.210526315789474 0.0333333333333333
GO:BP GO:0032872 regulation of stress-activated MAPK cascade 0.000638263097521224 190 14 4 0.285714285714286 0.0210526315789474
GO:BP GO:0098754 detoxification 0.000638263097521224 134 19 4 0.210526315789474 0.0298507462686567
GO:BP GO:0070302 regulation of stress-activated protein kinase signaling cascade 0.000652065678756281 193 14 4 0.285714285714286 0.0207253886010363
GO:BP GO:0006913 nucleocytoplasmic transport 0.000950177121863555 354 29 6 0.206896551724138 0.0169491525423729
GO:BP GO:0051169 nuclear transport 0.000964448314832978 357 29 6 0.206896551724138 0.0168067226890756
GO:BP GO:0000398 mRNA splicing, via spliceosome 0.00114354615636155 361 30 6 0.2 0.0166204986149584
GO:BP GO:0000387 spliceosomal snRNP assembly 0.00114354615636155 40 26 3 0.115384615384615 0.075
GO:BP GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 0.00114354615636155 361 30 6 0.2 0.0166204986149584
GO:BP GO:0032147 activation of protein kinase activity 0.00114354615636155 331 4 3 0.75 0.00906344410876133
GO:BP GO:0000375 RNA splicing, via transesterification reactions 0.00114354615636155 364 30 6 0.2 0.0164835164835165
GO:BP GO:0034622 cellular protein-containing complex assembly 0.0012242014237211 1107 28 9 0.321428571428571 0.00813008130081301
GO:BP GO:0051649 establishment of localization in cell 0.00147457288819782 2813 29 14 0.482758620689655 0.00497689299680057
GO:BP GO:0051403 stress-activated MAPK cascade 0.00180148964006569 272 14 4 0.285714285714286 0.0147058823529412
GO:BP GO:0006801 superoxide metabolic process 0.00180148964006569 67 19 3 0.157894736842105 0.0447761194029851
GO:BP GO:0031098 stress-activated protein kinase signaling cascade 0.00214861879902628 288 14 4 0.285714285714286 0.0138888888888889
GO:BP GO:0010941 regulation of cell death 0.00289603996474237 1720 4 4 1 0.00232558139534884
GO:BP GO:0043933 protein-containing complex subunit organization 0.00290826801352905 1963 28 11 0.392857142857143 0.00560366785532348
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.00290826801352905 3087 32 15 0.46875 0.00485908649173955
GO:BP GO:0008380 RNA splicing 0.00290826801352905 456 30 6 0.2 0.0131578947368421
GO:BP GO:0000302 response to reactive oxygen species 0.00299977074519028 237 19 4 0.210526315789474 0.0168776371308017
GO:BP GO:0006793 phosphorus metabolic process 0.00300613761907129 3114 32 15 0.46875 0.00481695568400771
GO:BP GO:0009636 response to toxic substance 0.00301657956816591 243 19 4 0.210526315789474 0.0164609053497942
GO:BP GO:0045860 positive regulation of protein kinase activity 0.00301657956816591 534 4 3 0.75 0.00561797752808989
GO:BP GO:0065003 protein-containing complex assembly 0.00350842469388795 1680 28 10 0.357142857142857 0.00595238095238095
GO:BP GO:0010257 NADH dehydrogenase complex assembly 0.00393278984140923 67 28 3 0.107142857142857 0.0447761194029851
GO:BP GO:0032981 mitochondrial respiratory chain complex I assembly 0.00393278984140923 67 28 3 0.107142857142857 0.0447761194029851
GO:BP GO:0033674 positive regulation of kinase activity 0.00393278984140923 608 4 3 0.75 0.00493421052631579
GO:BP GO:1902600 proton transmembrane transport 0.00421830179906607 157 32 4 0.125 0.0254777070063694
GO:BP GO:0060548 negative regulation of cell death 0.00467488462807118 1038 3 3 1 0.00289017341040462
GO:BP GO:0051347 positive regulation of transferase activity 0.00490803769491572 689 4 3 0.75 0.00435413642960813
GO:BP GO:0006397 mRNA processing 0.00490803769491572 532 30 6 0.2 0.0112781954887218
GO:BP GO:0006353 DNA-templated transcription, termination 0.00490803769491572 81 26 3 0.115384615384615 0.037037037037037
GO:BP GO:0008219 cell death 0.00554918578311801 2292 4 4 1 0.00174520069808028
GO:BP GO:0046907 intracellular transport 0.00556671555010279 1767 29 10 0.344827586206897 0.00565930956423316
GO:BP GO:0080134 regulation of response to stress 0.00628098336137646 1443 9 5 0.555555555555556 0.00346500346500346
GO:BP GO:0045859 regulation of protein kinase activity 0.00688205128730604 809 4 3 0.75 0.00370828182941904
GO:BP GO:0002443 leukocyte mediated immunity 0.00705946189435534 877 14 5 0.357142857142857 0.00570125427594071
GO:BP GO:0001934 positive regulation of protein phosphorylation 0.00732744543722675 840 4 3 0.75 0.00357142857142857
GO:BP GO:0043312 neutrophil degranulation 0.00748823864687156 482 14 4 0.285714285714286 0.00829875518672199
GO:BP GO:0002283 neutrophil activation involved in immune response 0.00758056701436129 485 14 4 0.285714285714286 0.00824742268041237
GO:BP GO:0051641 cellular localization 0.00772660785418157 3541 29 14 0.482758620689655 0.00395368539960463
GO:BP GO:0016071 mRNA metabolic process 0.00772660785418157 874 30 7 0.233333333333333 0.0080091533180778
GO:BP GO:0042119 neutrophil activation 0.00772660785418157 498 14 4 0.285714285714286 0.00803212851405622
GO:BP GO:0002446 neutrophil mediated immunity 0.00772660785418157 497 14 4 0.285714285714286 0.00804828973843058
GO:BP GO:0036230 granulocyte activation 0.00796398753061866 504 14 4 0.285714285714286 0.00793650793650794
GO:BP GO:0043085 positive regulation of catalytic activity 0.00810099629701555 1418 6 4 0.666666666666667 0.00282087447108604
GO:BP GO:0002262 myeloid cell homeostasis 0.00810099629701555 151 19 3 0.157894736842105 0.0198675496688742
GO:BP GO:0043549 regulation of kinase activity 0.00810099629701555 921 4 3 0.75 0.00325732899022801
GO:BP GO:0042327 positive regulation of phosphorylation 0.00812637371068114 927 4 3 0.75 0.00323624595469256
GO:BP GO:0033108 mitochondrial respiratory chain complex assembly 0.00825985198317346 103 28 3 0.107142857142857 0.029126213592233
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.00879111218683207 1477 6 4 0.666666666666667 0.002708192281652
GO:BP GO:0043299 leukocyte degranulation 0.00897208702979523 535 14 4 0.285714285714286 0.00747663551401869
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 0.00934013065809917 1001 4 3 0.75 0.002997002997003
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.00934013065809917 551 14 4 0.285714285714286 0.00725952813067151
GO:BP GO:0045937 positive regulation of phosphate metabolic process 0.00934013065809917 1001 4 3 0.75 0.002997002997003
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.00934013065809917 547 14 4 0.285714285714286 0.00731261425959781
GO:BP GO:0034614 cellular response to reactive oxygen species 0.00955000022664256 170 19 3 0.157894736842105 0.0176470588235294
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.00955000022664256 1037 4 3 0.75 0.00289296046287367
GO:BP GO:0051338 regulation of transferase activity 0.00955000022664256 1035 4 3 0.75 0.00289855072463768
GO:BP GO:0051247 positive regulation of protein metabolic process 0.00955000022664256 1564 6 4 0.666666666666667 0.00255754475703325
GO:BP GO:0043408 regulation of MAPK cascade 0.0100061035052067 730 19 5 0.263157894736842 0.00684931506849315
GO:BP GO:0031401 positive regulation of protein modification process 0.0102881087812543 1074 4 3 0.75 0.00279329608938547
GO:BP GO:0032392 DNA geometric change 0.0105253513163892 116 29 3 0.103448275862069 0.0258620689655172
GO:BP GO:0045055 regulated exocytosis 0.0120573461697865 785 19 5 0.263157894736842 0.00636942675159236
GO:BP GO:0051234 establishment of localization 0.0121847171854788 5372 29 17 0.586206896551724 0.00316455696202532
GO:BP GO:0000165 MAPK cascade 0.012310338023312 935 24 6 0.25 0.00641711229946524
GO:BP GO:0044093 positive regulation of molecular function 0.0126482310011328 1771 6 4 0.666666666666667 0.00225861095426313
GO:BP GO:0001932 regulation of protein phosphorylation 0.0130535286252298 1240 4 3 0.75 0.00241935483870968
GO:BP GO:0002274 myeloid leukocyte activation 0.0139483477509365 667 14 4 0.285714285714286 0.00599700149925037
GO:BP GO:0033554 cellular response to stress 0.0141709543692307 2111 25 9 0.36 0.00426338228327807
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.0150564722336084 810 29 6 0.206896551724138 0.00740740740740741
GO:BP GO:0060326 cell chemotaxis 0.0151040868363436 310 14 3 0.214285714285714 0.00967741935483871
GO:BP GO:0071345 cellular response to cytokine stimulus 0.0160537579525321 1132 29 7 0.241379310344828 0.00618374558303887
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0163794418381048 717 14 4 0.285714285714286 0.00557880055788006
GO:BP GO:0097659 nucleic acid-templated transcription 0.0163794418381048 3715 4 4 1 0.00107671601615074
GO:BP GO:0006351 transcription, DNA-templated 0.0163794418381048 3714 4 4 1 0.00107700592353258
GO:BP GO:0032774 RNA biosynthetic process 0.0165087405056904 3731 4 4 1 0.00107209863307424
GO:BP GO:0002263 cell activation involved in immune response 0.016532902184194 721 14 4 0.285714285714286 0.00554785020804438
GO:BP GO:0042325 regulation of phosphorylation 0.0166456773059266 1431 4 3 0.75 0.00209643605870021
GO:BP GO:0045321 leukocyte activation 0.0166456773059266 1332 19 6 0.315789473684211 0.0045045045045045
GO:BP GO:0051170 import into nucleus 0.0166456773059266 172 26 3 0.115384615384615 0.0174418604651163
GO:BP GO:0006887 exocytosis 0.0173754704650682 904 19 5 0.263157894736842 0.00553097345132743
GO:BP GO:0038061 NIK/NF-kappaB signaling 0.0179675309192028 194 24 3 0.125 0.0154639175257732
GO:BP GO:0043066 negative regulation of apoptotic process 0.0184133299229 921 19 5 0.263157894736842 0.00542888165038002
GO:BP GO:0002252 immune effector process 0.0186188339957511 1309 14 5 0.357142857142857 0.00381970970206264
GO:BP GO:0042981 regulation of apoptotic process 0.0189289372723877 1549 4 3 0.75 0.00193673337637185
GO:BP GO:0043069 negative regulation of programmed cell death 0.0191309664249309 943 19 5 0.263157894736842 0.00530222693531283
GO:BP GO:0048872 homeostasis of number of cells 0.0191915183252174 261 19 3 0.157894736842105 0.0114942528735632
GO:BP GO:0007005 mitochondrion organization 0.0191961158503032 561 31 5 0.161290322580645 0.0089126559714795
GO:BP GO:0043067 regulation of programmed cell death 0.0194648598816105 1582 4 3 0.75 0.00189633375474083
GO:BP GO:0006367 transcription initiation from RNA polymerase II promoter 0.0197652436856218 200 25 3 0.12 0.015
GO:BP GO:0009967 positive regulation of signal transduction 0.0197652436856218 1598 4 3 0.75 0.00187734668335419
GO:BP GO:0006810 transport 0.0197942259584515 5224 29 16 0.551724137931034 0.00306278713629403
GO:BP GO:0062012 regulation of small molecule metabolic process 0.0197942259584515 447 24 4 0.166666666666667 0.00894854586129754
GO:BP GO:0034097 response to cytokine 0.019834370463277 1226 29 7 0.241379310344828 0.00570962479608483
GO:BP GO:0022618 ribonucleoprotein complex assembly 0.0200177911886452 197 26 3 0.115384615384615 0.0152284263959391
GO:BP GO:0051174 regulation of phosphorus metabolic process 0.0201797377041702 1645 4 3 0.75 0.00182370820668693
GO:BP GO:0019220 regulation of phosphate metabolic process 0.0201797377041702 1645 4 3 0.75 0.00182370820668693
GO:BP GO:0044237 cellular metabolic process 0.0201797377041702 10871 32 27 0.84375 0.0024836721552755
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 0.0204380462169849 4199 4 4 1 0.000952607763753275
GO:BP GO:0006468 protein phosphorylation 0.0204865157043915 1668 4 3 0.75 0.00179856115107914
GO:BP GO:0031399 regulation of protein modification process 0.02050656107476 1671 4 3 0.75 0.00179533213644524
GO:BP GO:0018130 heterocycle biosynthetic process 0.0207385221447586 4269 4 4 1 0.0009369875849145
GO:BP GO:0071826 ribonucleoprotein complex subunit organization 0.0207385221447586 204 26 3 0.115384615384615 0.0147058823529412
GO:BP GO:0019438 aromatic compound biosynthetic process 0.0207674581117253 4278 4 4 1 0.000935016362786349
GO:BP GO:0006611 protein export from nucleus 0.0209692535187215 185 29 3 0.103448275862069 0.0162162162162162
GO:BP GO:0072593 reactive oxygen species metabolic process 0.0214025789234793 290 19 3 0.157894736842105 0.0103448275862069
GO:BP GO:0001775 cell activation 0.02154885634978 1495 19 6 0.315789473684211 0.0040133779264214
GO:BP GO:0010647 positive regulation of cell communication 0.0221523013929433 1777 4 3 0.75 0.00168823860438942
GO:BP GO:0023056 positive regulation of signaling 0.0221523013929433 1782 4 3 0.75 0.00168350168350168
GO:BP GO:0051049 regulation of transport 0.0224315922740609 1809 4 3 0.75 0.00165837479270315
GO:BP GO:1901362 organic cyclic compound biosynthetic process 0.0224315922740609 4439 4 4 1 0.000901103852218968
GO:BP GO:0006259 DNA metabolic process 0.0224315922740609 965 29 6 0.206896551724138 0.00621761658031088
GO:BP GO:1902531 regulation of intracellular signal transduction 0.0229095072923686 1842 4 3 0.75 0.00162866449511401
GO:BP GO:0043405 regulation of MAP kinase activity 0.0235821326302574 316 19 3 0.157894736842105 0.00949367088607595
GO:BP GO:0051168 nuclear export 0.0235821326302574 204 29 3 0.103448275862069 0.0147058823529412
GO:BP GO:0006396 RNA processing 0.0245555299027158 964 30 6 0.2 0.00622406639004149
GO:BP GO:0050790 regulation of catalytic activity 0.025044143753658 2545 6 4 0.666666666666667 0.00157170923379175
GO:BP GO:0016070 RNA metabolic process 0.025044143753658 4710 4 4 1 0.000849256900212314
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.025044143753658 2541 6 4 0.666666666666667 0.00157418339236521
GO:BP GO:0006915 apoptotic process 0.0255336850135844 1990 4 3 0.75 0.00150753768844221
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.026469448113804 3083 8 5 0.625 0.00162179695102173
GO:BP GO:0006352 DNA-templated transcription, initiation 0.0275091463831974 262 25 3 0.12 0.0114503816793893
GO:BP GO:0051246 regulation of protein metabolic process 0.0283213719952501 2704 6 4 0.666666666666667 0.0014792899408284
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 0.0284515277182863 5017 4 4 1 0.000797289216663345
GO:BP GO:0012501 programmed cell death 0.0287000047716494 2143 4 3 0.75 0.00139990667288847
GO:BP GO:0034645 cellular macromolecule biosynthetic process 0.0287000047716494 5051 4 4 1 0.000791922391605623
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.0288745505250106 363 19 3 0.157894736842105 0.00826446280991736
GO:BP GO:0009059 macromolecule biosynthetic process 0.0295395477053062 5114 4 4 1 0.000782166601486116
GO:BP GO:0048523 negative regulation of cellular process 0.0297393820710018 5139 4 4 1 0.000778361548939482
GO:BP GO:0006950 response to stress 0.0297393820710018 4170 9 6 0.666666666666667 0.00143884892086331
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.03000015637943 3274 8 5 0.625 0.0015271838729383
GO:BP GO:0090304 nucleic acid metabolic process 0.0306250823077235 5226 4 4 1 0.000765403750478377
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.0316838425683521 1227 19 5 0.263157894736842 0.00407497962510187
GO:BP GO:0070887 cellular response to chemical stimulus 0.0317117771093852 3393 31 12 0.387096774193548 0.00353669319186561
GO:BP GO:0048584 positive regulation of response to stimulus 0.0327442875991016 2344 4 3 0.75 0.00127986348122867
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.035170566597359 3483 8 5 0.625 0.00143554407120299
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.0367754309181811 2518 4 3 0.75 0.00119142176330421
GO:BP GO:0006886 intracellular protein transport 0.037720972458823 1186 29 6 0.206896551724138 0.00505902192242833
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.0378059524154036 5746 4 4 1 0.000696136442742778
GO:BP GO:0048519 negative regulation of biological process 0.0380065295325438 5757 4 4 1 0.000694806322737537
GO:BP GO:0019725 cellular homeostasis 0.0384268205429704 981 9 3 0.333333333333333 0.00305810397553517
GO:BP GO:0065009 regulation of molecular function 0.0396026832563129 3221 6 4 0.666666666666667 0.00124185035703198
GO:BP GO:0046483 heterocycle metabolic process 0.0401297616680723 5904 4 4 1 0.000677506775067751
GO:BP GO:0022607 cellular component assembly 0.0401998869523808 3010 28 10 0.357142857142857 0.00332225913621262
GO:BP GO:0032940 secretion by cell 0.0401998869523808 1364 19 5 0.263157894736842 0.00366568914956012
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.0406821384338395 5956 4 4 1 0.000671591672263264
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.0414353444002741 2719 4 3 0.75 0.00110334681868334
GO:BP GO:0009893 positive regulation of metabolic process 0.0428567086821847 3783 8 5 0.625 0.00132170235263019
GO:BP GO:0035556 intracellular signal transduction 0.0431635230371231 2772 4 3 0.75 0.00108225108225108
GO:BP GO:0031347 regulation of defense response 0.0437550424357136 704 24 4 0.166666666666667 0.00568181818181818
GO:BP GO:0042221 response to chemical 0.0440317243589259 4781 9 6 0.666666666666667 0.00125496758000418
GO:BP GO:0044249 cellular biosynthetic process 0.0443041201377788 6154 4 4 1 0.00064998375040624
GO:BP GO:0140352 export from cell 0.0445771591494936 1418 19 5 0.263157894736842 0.00352609308885755
GO:BP GO:0010467 gene expression 0.0448470535852469 6179 4 4 1 0.000647353940767114
GO:BP GO:1901360 organic cyclic compound metabolic process 0.044911998920429 6201 4 4 1 0.000645057248830834
GO:BP GO:0032879 regulation of localization 0.04516306817603 2872 4 3 0.75 0.00104456824512535
GO:BP GO:1901576 organic substance biosynthetic process 0.0452426916328792 6248 4 4 1 0.000640204865556978
GO:BP GO:0008152 metabolic process 0.0460312381614644 11827 32 27 0.84375 0.00228291198106029
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 0.0463103328528427 503 19 3 0.157894736842105 0.00596421471172962
GO:BP GO:0009058 biosynthetic process 0.0463445770985121 6340 4 4 1 0.000630914826498423
GO:BP GO:0046903 secretion 0.0492051164940847 1501 19 5 0.263157894736842 0.0033311125916056
GO:BP GO:0034641 cellular nitrogen compound metabolic process 0.049845823563209 6563 4 4 1 0.000609477373152522
GO:CC GO:0070469 respirasome 1.4074909539588e-11 103 32 9 0.28125 0.087378640776699
GO:CC GO:0098803 respiratory chain complex 1.1926045701437e-10 86 32 8 0.25 0.0930232558139535
GO:CC GO:0070069 cytochrome complex 1.20674066406688e-07 34 32 5 0.15625 0.147058823529412
GO:CC GO:0005746 mitochondrial respirasome 1.20674066406688e-07 89 28 6 0.214285714285714 0.0674157303370786
GO:CC GO:0005740 mitochondrial envelope 1.20674066406688e-07 797 32 12 0.375 0.0150564617314931
GO:CC GO:0005743 mitochondrial inner membrane 1.94077354737283e-07 503 32 10 0.3125 0.0198807157057654
GO:CC GO:0019866 organelle inner membrane 4.94122838343248e-07 564 32 10 0.3125 0.0177304964539007
GO:CC GO:0045277 respiratory chain complex IV 9.45403824682922e-07 21 32 4 0.125 0.19047619047619
GO:CC GO:0098800 inner mitochondrial membrane protein complex 1.20392873624221e-06 146 28 6 0.214285714285714 0.0410958904109589
GO:CC GO:0043231 intracellular membrane-bounded organelle 1.20392873624221e-06 11296 32 32 1 0.0028328611898017
GO:CC GO:0005689 U12-type spliceosomal complex 1.78143782221228e-06 28 30 4 0.133333333333333 0.142857142857143
GO:CC GO:0032991 protein-containing complex 1.84272752408398e-06 5548 32 24 0.75 0.00432588320115357
GO:CC GO:0005739 mitochondrion 2.1415687900747e-06 1673 32 14 0.4375 0.00836820083682008
GO:CC GO:0097526 spliceosomal tri-snRNP complex 2.1415687900747e-06 32 30 4 0.133333333333333 0.125
GO:CC GO:0046540 U4/U6 x U5 tri-snRNP complex 2.1415687900747e-06 32 30 4 0.133333333333333 0.125
GO:CC GO:1902494 catalytic complex 2.1415687900747e-06 1441 31 13 0.419354838709677 0.00902151283830673
GO:CC GO:0071013 catalytic step 2 spliceosome 2.38136671642698e-06 85 30 5 0.166666666666667 0.0588235294117647
GO:CC GO:0031966 mitochondrial membrane 2.63745964705611e-06 746 32 10 0.3125 0.0134048257372654
GO:CC GO:0005687 U4 snRNP 2.77265511840077e-06 10 26 3 0.115384615384615 0.3
GO:CC GO:0031967 organelle envelope 3.44390323851335e-06 1237 32 12 0.375 0.00970088924818108
GO:CC GO:0031975 envelope 3.44390323851335e-06 1237 32 12 0.375 0.00970088924818108
GO:CC GO:0034709 methylosome 4.38205255437089e-06 12 26 3 0.115384615384615 0.25
GO:CC GO:1990204 oxidoreductase complex 5.08485402413443e-06 113 28 5 0.178571428571429 0.0442477876106195
GO:CC GO:0030964 NADH dehydrogenase complex 6.72796489294746e-06 51 28 4 0.142857142857143 0.0784313725490196
GO:CC GO:0045271 respiratory chain complex I 6.72796489294746e-06 51 28 4 0.142857142857143 0.0784313725490196
GO:CC GO:0005747 mitochondrial respiratory chain complex I 6.72796489294746e-06 51 28 4 0.142857142857143 0.0784313725490196
GO:CC GO:0071005 U2-type precatalytic spliceosome 7.96857582442237e-06 50 30 4 0.133333333333333 0.08
GO:CC GO:0071011 precatalytic spliceosome 9.0129582240814e-06 52 30 4 0.133333333333333 0.0769230769230769
GO:CC GO:0043229 intracellular organelle 1.04124079118461e-05 12491 32 32 1 0.0025618445280602
GO:CC GO:1904813 ficolin-1-rich granule lumen 1.06682436976861e-05 124 14 4 0.285714285714286 0.032258064516129
GO:CC GO:0034719 SMN-Sm protein complex 1.14718734579151e-05 18 26 3 0.115384615384615 0.166666666666667
GO:CC GO:0005685 U1 snRNP 1.2785580852346e-05 19 26 3 0.115384615384615 0.157894736842105
GO:CC GO:0097525 spliceosomal snRNP complex 1.2785580852346e-05 59 30 4 0.133333333333333 0.0677966101694915
GO:CC GO:0098798 mitochondrial protein-containing complex 1.29665214512543e-05 270 28 6 0.214285714285714 0.0222222222222222
GO:CC GO:0030532 small nuclear ribonucleoprotein complex 2.12118490795255e-05 68 30 4 0.133333333333333 0.0588235294117647
GO:CC GO:0043227 membrane-bounded organelle 2.12118490795255e-05 12858 32 32 1 0.00248872297402395
GO:CC GO:0098796 membrane protein complex 3.11699416647309e-05 1322 32 11 0.34375 0.00832072617246596
GO:CC GO:0005737 cytoplasm 3.46185580983473e-05 11911 32 31 0.96875 0.00260263621862144
GO:CC GO:0120114 Sm-like protein family complex 3.66585279215697e-05 80 30 4 0.133333333333333 0.05
GO:CC GO:0101002 ficolin-1-rich granule 3.84289454935058e-05 184 14 4 0.285714285714286 0.0217391304347826
GO:CC GO:0071007 U2-type catalytic step 2 spliceosome 4.26879666020611e-05 30 26 3 0.115384615384615 0.1
GO:CC GO:0031974 membrane-enclosed lumen 4.90462486747625e-05 5565 31 21 0.67741935483871 0.00377358490566038
GO:CC GO:0043233 organelle lumen 4.90462486747625e-05 5565 31 21 0.67741935483871 0.00377358490566038
GO:CC GO:0005681 spliceosomal complex 5.01514073508847e-05 191 30 5 0.166666666666667 0.0261780104712042
GO:CC GO:0005758 mitochondrial intermembrane space 5.07670338026434e-05 87 31 4 0.129032258064516 0.0459770114942529
GO:CC GO:0005684 U2-type spliceosomal complex 5.65635823711096e-05 93 30 4 0.133333333333333 0.043010752688172
GO:CC GO:0031970 organelle envelope lumen 7.48040881947167e-05 97 31 4 0.129032258064516 0.0412371134020619
GO:CC GO:0043226 organelle 0.000237561089779996 14008 32 32 1 0.00228440890919475
GO:CC GO:0034774 secretory granule lumen 0.000263914328570862 320 14 4 0.285714285714286 0.0125
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.000271626302791488 324 14 4 0.285714285714286 0.0123456790123457
GO:CC GO:0031983 vesicle lumen 0.000272941540507456 326 14 4 0.285714285714286 0.0122699386503067
GO:CC GO:0005829 cytosol 0.00116286571787817 5303 26 16 0.615384615384615 0.0030171600980577
GO:CC GO:0005622 intracellular anatomical structure 0.00116286571787817 14790 32 32 1 0.00216362407031778
GO:CC GO:0070062 extracellular exosome 0.0013195561226341 2176 22 9 0.409090909090909 0.00413602941176471
GO:CC GO:0034708 methyltransferase complex 0.00143277897490334 111 26 3 0.115384615384615 0.027027027027027
GO:CC GO:0070013 intracellular organelle lumen 0.00165707606601227 5402 31 18 0.580645161290323 0.00333209922251018
GO:CC GO:1903561 extracellular vesicle 0.00166240305443196 2261 22 9 0.409090909090909 0.00398053958425475
GO:CC GO:0043230 extracellular organelle 0.00166240305443196 2263 22 9 0.409090909090909 0.00397702165267344
GO:CC GO:1990904 ribonucleoprotein complex 0.00182287418749793 688 30 6 0.2 0.00872093023255814
GO:CC GO:0030141 secretory granule 0.00351029531015042 851 19 5 0.263157894736842 0.00587544065804935
GO:CC GO:0005634 nucleus 0.00460029939684351 7592 31 21 0.67741935483871 0.00276606954689146
GO:CC GO:0099503 secretory vesicle 0.00734706868222035 1020 19 5 0.263157894736842 0.00490196078431373
GO:CC GO:0140513 nuclear protein-containing complex 0.00734706868222035 1249 30 7 0.233333333333333 0.0056044835868695
GO:CC GO:0031982 vesicle 0.00734706868222035 4055 22 11 0.5 0.00271270036991369
GO:CC GO:0005615 extracellular space 0.0102952199742886 3594 22 10 0.454545454545455 0.00278241513633834
GO:CC GO:0031981 nuclear lumen 0.0109111978547545 4444 30 14 0.466666666666667 0.00315031503150315
GO:CC GO:0005654 nucleoplasm 0.0153821482488489 4102 30 13 0.433333333333333 0.00316918576304242
GO:CC GO:0005576 extracellular region 0.017857779622566 4567 22 11 0.5 0.00240858331508649
GO:CC GO:0031090 organelle membrane 0.0252679205541124 3612 32 12 0.375 0.00332225913621262
GO:CC GO:1990234 transferase complex 0.0436013030868656 804 26 4 0.153846153846154 0.00497512437810945
GO:CC GO:0031410 cytoplasmic vesicle 0.0469717927052171 2424 14 5 0.357142857142857 0.00206270627062706
GO:CC GO:0097708 intracellular vesicle 0.0469717927052171 2428 14 5 0.357142857142857 0.00205930807248764
GO:MF GO:0009055 electron transfer activity 2.41749513611962e-08 148 32 8 0.25 0.0540540540540541
GO:MF GO:0016491 oxidoreductase activity 2.49228079373644e-07 771 32 12 0.375 0.0155642023346304
GO:MF GO:0004129 cytochrome-c oxidase activity 4.94101463288012e-06 27 32 4 0.125 0.148148148148148
GO:MF GO:0016675 oxidoreductase activity, acting on a heme group of donors 4.94101463288012e-06 28 32 4 0.125 0.142857142857143
GO:MF GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 4.94101463288012e-06 27 32 4 0.125 0.148148148148148
GO:MF GO:0015002 heme-copper terminal oxidase activity 4.94101463288012e-06 27 32 4 0.125 0.148148148148148
GO:MF GO:0016209 antioxidant activity 4.8421102423854e-05 87 19 4 0.210526315789474 0.0459770114942529
GO:MF GO:0016651 oxidoreductase activity, acting on NAD(P)H 0.000217663529505761 107 23 4 0.173913043478261 0.0373831775700935
GO:MF GO:0008137 NADH dehydrogenase (ubiquinone) activity 0.000418691269635976 46 23 3 0.130434782608696 0.0652173913043478
GO:MF GO:0003954 NADH dehydrogenase activity 0.000418691269635976 46 23 3 0.130434782608696 0.0652173913043478
GO:MF GO:0050136 NADH dehydrogenase (quinone) activity 0.000418691269635976 46 23 3 0.130434782608696 0.0652173913043478
GO:MF GO:0003723 RNA binding 0.000418691269635976 1943 30 12 0.4 0.00617601646937725
GO:MF GO:0003955 NAD(P)H dehydrogenase (quinone) activity 0.000467947832715428 49 23 3 0.130434782608696 0.0612244897959184
GO:MF GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 0.000832707886109927 61 23 3 0.130434782608696 0.0491803278688525
GO:MF GO:0015078 proton transmembrane transporter activity 0.000832707886109927 125 32 4 0.125 0.032
GO:MF GO:0003697 single-stranded DNA binding 0.00714590576535595 119 29 3 0.103448275862069 0.0252100840336134
GO:MF GO:0042277 peptide binding 0.0101157985300879 314 14 3 0.214285714285714 0.00955414012738853
GO:MF GO:0050839 cell adhesion molecule binding 0.0116450805541535 546 9 3 0.333333333333333 0.00549450549450549
GO:MF GO:0008134 transcription factor binding 0.0117572940883271 676 8 3 0.375 0.00443786982248521
GO:MF GO:0033218 amide binding 0.0128397618569488 389 14 3 0.214285714285714 0.0077120822622108
GO:MF GO:0003676 nucleic acid binding 0.0145351904110037 4276 30 14 0.466666666666667 0.00327408793264733
GO:MF GO:0005515 protein binding 0.0410823004778329 14767 26 25 0.961538461538462 0.00169296404144376
GO:MF GO:0044877 protein-containing complex binding 0.0410823004778329 1287 23 5 0.217391304347826 0.00388500388500389
GO:MF GO:0022890 inorganic cation transmembrane transporter activity 0.0410823004778329 591 32 4 0.125 0.00676818950930626
GO:MF GO:0015075 ion transmembrane transporter activity 0.0466511571289169 956 32 5 0.15625 0.00523012552301255
GO:MF GO:0003824 catalytic activity 0.0466511571289169 5896 27 14 0.518518518518518 0.00237449118046133
GO:MF GO:0008324 cation transmembrane transporter activity 0.0469930958185372 639 32 4 0.125 0.00625978090766823
HPA HPA:0530723 spleen; cells in white pulp[High] 0.00584345048807132 811 22 9 0.409090909090909 0.0110974106041924
HPA HPA:0250122 hippocampus; glial cells[≥Medium] 0.0358390214280735 1926 22 11 0.5 0.00571131879543095
HPA HPA:0090183 cerebellum; cells in granular layer[High] 0.0358390214280735 709 22 7 0.318181818181818 0.00987306064880113
HPA HPA:0250123 hippocampus; glial cells[High] 0.0358390214280735 508 29 7 0.241379310344828 0.0137795275590551
HPA HPA:0390053 prostate; glandular cells[High] 0.0358390214280735 1284 31 11 0.354838709677419 0.00856697819314642
HPA HPA:0530722 spleen; cells in white pulp[≥Medium] 0.0358390214280735 2645 22 13 0.590909090909091 0.00491493383742911
HPA HPA:0530713 spleen; cells in red pulp[High] 0.0358390214280735 778 22 7 0.318181818181818 0.0089974293059126
KEGG KEGG:05012 Parkinson disease 5.23804609879664e-08 249 32 11 0.34375 0.0441767068273092
KEGG KEGG:05016 Huntington disease 5.23804609879664e-08 306 32 12 0.375 0.0392156862745098
KEGG KEGG:05020 Prion disease 7.42675556755565e-08 273 32 11 0.34375 0.0402930402930403
KEGG KEGG:04932 Non-alcoholic fatty liver disease 7.42675556755565e-08 150 32 9 0.28125 0.06
KEGG KEGG:05014 Amyotrophic lateral sclerosis 8.57177702761546e-08 363 32 12 0.375 0.0330578512396694
KEGG KEGG:00190 Oxidative phosphorylation 4.02243695749941e-07 133 32 8 0.25 0.0601503759398496
KEGG KEGG:05010 Alzheimer disease 8.50328892956915e-06 369 32 10 0.3125 0.02710027100271
KEGG KEGG:05415 Diabetic cardiomyopathy 8.50328892956915e-06 203 32 8 0.25 0.0394088669950739
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 8.97307330747972e-06 475 32 11 0.34375 0.0231578947368421
KEGG KEGG:04714 Thermogenesis 1.73567747088173e-05 232 32 8 0.25 0.0344827586206897
KEGG KEGG:04260 Cardiac muscle contraction 0.00229803751068932 87 32 4 0.125 0.0459770114942529
KEGG KEGG:04723 Retrograde endocannabinoid signaling 0.00852140487056955 148 28 4 0.142857142857143 0.027027027027027
KEGG KEGG:03040 Spliceosome 0.0103981814406036 150 30 4 0.133333333333333 0.0266666666666667
MIRNA MIRNA:hsa-miR-320a hsa-miR-320a 0.0308548036258508 584 27 6 0.222222222222222 0.0102739726027397
MIRNA MIRNA:hsa-miR-18a-3p hsa-miR-18a-3p 0.0438258927417536 348 9 3 0.333333333333333 0.00862068965517241
REAC REAC:R-HSA-611105 Respiratory electron transport 3.38934422859617e-09 100 32 9 0.28125 0.09
REAC REAC:R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1.20543414009111e-08 124 32 9 0.28125 0.0725806451612903
REAC REAC:R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 1.67419837090361e-07 174 32 9 0.28125 0.0517241379310345
REAC REAC:R-HSA-5628897 TP53 Regulates Metabolic Genes 3.49493439636033e-07 83 32 7 0.21875 0.0843373493975904
REAC REAC:R-HSA-3299685 Detoxification of Reactive Oxygen Species 2.67761984059464e-06 35 31 5 0.161290322580645 0.142857142857143
REAC REAC:R-HSA-9711123 Cellular response to chemical stress 2.67761984059464e-06 35 31 5 0.161290322580645 0.142857142857143
REAC REAC:R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 0.000122822745837321 36 29 4 0.137931034482759 0.111111111111111
REAC REAC:R-HSA-72165 mRNA Splicing - Minor Pathway 0.000250601081003566 51 26 4 0.153846153846154 0.0784313725490196
REAC REAC:R-HSA-9020591 Interleukin-12 signaling 0.000250601081003566 45 29 4 0.137931034482759 0.0888888888888889
REAC REAC:R-HSA-72163 mRNA Splicing - Major Pathway 0.000275708067776215 178 30 6 0.2 0.0337078651685393
REAC REAC:R-HSA-3700989 Transcriptional Regulation by TP53 0.000275708067776215 360 32 8 0.25 0.0222222222222222
REAC REAC:R-HSA-72172 mRNA Splicing 0.000325077695483462 186 30 6 0.2 0.032258064516129
REAC REAC:R-HSA-447115 Interleukin-12 family signaling 0.000369345244660449 55 29 4 0.137931034482759 0.0727272727272727
REAC REAC:R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.00104683072999323 235 30 6 0.2 0.025531914893617
REAC REAC:R-HSA-194441 Metabolism of non-coding RNA 0.0038225367433541 49 26 3 0.115384615384615 0.0612244897959184
REAC REAC:R-HSA-191859 snRNP Assembly 0.0038225367433541 49 26 3 0.115384615384615 0.0612244897959184
REAC REAC:R-HSA-6799198 Complex I biogenesis 0.00586211046156623 55 28 3 0.107142857142857 0.0545454545454545
REAC REAC:R-HSA-73857 RNA Polymerase II Transcription 0.0136315197159081 1301 32 11 0.34375 0.00845503458877786
REAC REAC:R-HSA-449147 Signaling by Interleukins 0.0142813615830614 446 29 6 0.206896551724138 0.0134529147982063
REAC REAC:R-HSA-114608 Platelet degranulation 0.0164672447136675 125 19 3 0.157894736842105 0.024
REAC REAC:R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.0177997643588229 130 19 3 0.157894736842105 0.0230769230769231
REAC REAC:R-HSA-8953854 Metabolism of RNA 0.020929591402764 658 30 7 0.233333333333333 0.0106382978723404
REAC REAC:R-HSA-74160 Gene expression (Transcription) 0.0227929945757398 1435 32 11 0.34375 0.00766550522648084
REAC REAC:R-HSA-168249 Innate Immune System 0.0232877073372023 1073 25 8 0.32 0.00745573159366263
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.0244940660575687 474 14 4 0.285714285714286 0.00843881856540084
REAC REAC:R-HSA-2262752 Cellular responses to stress 0.0364813391859362 546 31 6 0.193548387096774 0.010989010989011
REAC REAC:R-HSA-1430728 Metabolism 0.0368884025829727 2070 32 13 0.40625 0.00628019323671498
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 0.0368884025829727 560 31 6 0.193548387096774 0.0107142857142857
REAC REAC:R-HSA-212436 Generic Transcription Pathway 0.0428348542127166 1180 32 9 0.28125 0.0076271186440678
TF TF:M08510 Factor: TEF-3:Fli-1; motif: ACCGGAAATGCC 0.00564353919599469 7360 25 21 0.84 0.00285326086956522
TF TF:M03975_1 Factor: ERG; motif: ACCGGAARTN; match class: 1 0.00564353919599469 4024 22 15 0.681818181818182 0.00372763419483101
TF TF:M09608_1 Factor: Erg; motif: NNACCGGAARTSN; match class: 1 0.00617178559947124 2389 23 12 0.521739130434783 0.00502302218501465
TF TF:M01253_1 Factor: CNOT3; motif: GGCCGCGSSS; match class: 1 0.00710256821486212 1026 4 4 1 0.00389863547758285
TF TF:M03988_1 Factor: FLI1; motif: ACCGGAARTN; match class: 1 0.00710256821486212 2950 18 11 0.611111111111111 0.00372881355932203
TF TF:M11404_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.00710256821486212 3171 29 15 0.517241379310345 0.00473036896877956
TF TF:M08345 Factor: HOXB2:PEA3; motif: ACCGGAAATGRN 0.00710256821486212 8027 13 13 1 0.00161953407250529
TF TF:M02064_1 Factor: c-ets-2; motif: ACCGGAWRTN; match class: 1 0.0139836844231216 4592 23 15 0.652173913043478 0.00326655052264808
TF TF:M02056 Factor: ELF4; motif: NCCGGAARTN 0.0140871448604036 5332 13 11 0.846153846153846 0.00206301575393848
TF TF:M08913_1 Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 0.0193769972998413 3055 18 10 0.555555555555556 0.00327332242225859
TF TF:M02074 Factor: GABPalpha; motif: RCCGGAWRYN 0.0193769972998413 4607 13 10 0.769230769230769 0.00217060994139353
TF TF:M12185_1 Factor: BTEB4; motif: RCCACGCCCC; match class: 1 0.0193769972998413 334 28 5 0.178571428571429 0.0149700598802395
TF TF:M11882_1 Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 0.0193769972998413 11423 32 29 0.90625 0.00253873763459687
TF TF:M08510_1 Factor: TEF-3:Fli-1; motif: ACCGGAAATGCC; match class: 1 0.0193769972998413 1700 29 10 0.344827586206897 0.00588235294117647
TF TF:M08982_1 Factor: YY1; motif: NAANATGGCGNNN; match class: 1 0.0193769972998413 1662 30 10 0.333333333333333 0.00601684717208183
TF TF:M00803 Factor: E2F; motif: GGCGSG 0.0193769972998413 13190 32 31 0.96875 0.0023502653525398
TF TF:M11419_1 Factor: ER81; motif: NNCCGGAWGYN; match class: 1 0.0193769972998413 1427 27 9 0.333333333333333 0.00630693763139453
TF TF:M02059_1 Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 0.0193769972998413 3759 18 11 0.611111111111111 0.00292631018888002
TF TF:M02052_1 Factor: EHF; motif: CSCGGAARTN; match class: 1 0.0193769972998413 4056 17 11 0.647058823529412 0.0027120315581854
TF TF:M11438_1 Factor: SAP-1; motif: NTCGTAAATGCN; match class: 1 0.0193769972998413 1191 32 9 0.28125 0.00755667506297229
TF TF:M02061 Factor: ERF; motif: ACCGGAARYN 0.0193769972998413 2579 23 11 0.478260869565217 0.00426521907716169
TF TF:M04710_1 Factor: CHD2; motif: TCTCGCGAG; match class: 1 0.0193769972998413 11477 32 29 0.90625 0.00252679271586652
TF TF:M11535 Factor: E2F-4; motif: TTTTGGCGCCAWWN 0.0193769972998413 10884 32 28 0.875 0.00257258360896729
TF TF:M12165_1 Factor: BTEB2; motif: NCCACRCCCN; match class: 1 0.0193769972998413 940 30 8 0.266666666666667 0.00851063829787234
TF TF:M10591_1 Factor: BSX; motif: NNCGTTAN; match class: 1 0.0193769972998413 2259 31 12 0.387096774193548 0.00531208499335989
TF TF:M10880_1 Factor: Alx-4; motif: NNCRTTAN; match class: 1 0.0193769972998413 2683 31 13 0.419354838709677 0.00484532240029817
TF TF:M01752_1 Factor: ERG; motif: ACCGGAART; match class: 1 0.0193769972998413 3705 18 11 0.611111111111111 0.00296896086369771
TF TF:M07380 Factor: E2F-4; motif: NTTTCSCGCC 0.0193769972998413 13022 22 22 1 0.00168944862540316
TF TF:M02062_1 Factor: Erg; motif: ACCGGAAGTN; match class: 1 0.0193769972998413 2718 13 8 0.615384615384615 0.00294334069168506
TF TF:M03981 Factor: ETV3; motif: ACCGGAAGTN 0.0213687290421233 2327 23 10 0.434782608695652 0.00429737859905458
TF TF:M08423 Factor: TEF-3:ER81; motif: ACCGGAAATRCC 0.0213687290421233 3845 13 9 0.692307692307692 0.0023407022106632
TF TF:M00940_1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 0.0213687290421233 2643 32 13 0.40625 0.00491865304578131
TF TF:M11436 Factor: SAP-1; motif: NRNCGGAWRYN 0.0213687290421233 1431 23 8 0.347826086956522 0.00559049615653389
TF TF:M11392_1 Factor: Erg; motif: NACCGGAARYN; match class: 1 0.0231410841630215 3233 18 10 0.555555555555556 0.00309310238168883
TF TF:M10849_1 Factor: Cdx-2; motif: NRTCGTAANNNN; match class: 1 0.0231410841630215 4497 32 17 0.53125 0.00378029797642873
TF TF:M02062 Factor: Erg; motif: ACCGGAAGTN 0.0231410841630215 8056 13 12 0.923076923076923 0.00148957298907646
TF TF:M09608 Factor: Erg; motif: NNACCGGAARTSN 0.0231410841630215 8152 13 12 0.923076923076923 0.0014720314033366
TF TF:M00678 Factor: Tel-2; motif: YTACTTCCTG 0.0231410841630215 5292 17 12 0.705882352941177 0.00226757369614512
TF TF:M11407 Factor: Pet-1; motif: NACCGGAAGTN 0.0231410841630215 772 23 6 0.260869565217391 0.0077720207253886
TF TF:M11682 Factor: IRF-8; motif: NYGAAASYGAAACYN 0.0231410841630215 3795 11 8 0.727272727272727 0.00210803689064559
TF TF:M11005_1 Factor: LHX4; motif: NNCRTTAN; match class: 1 0.0231410841630215 4203 31 16 0.516129032258065 0.00380680466333571
TF TF:M00327_1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 0.0231410841630215 6888 31 21 0.67741935483871 0.00304878048780488
TF TF:M11389 Factor: elf5; motif: GAMCCGGAAGTN 0.0231410841630215 1308 20 7 0.35 0.00535168195718654
TF TF:M00025 Factor: Elk-1; motif: NNNNCCGGAARTNN 0.0231410841630215 10262 13 13 1 0.00126680958877412
TF TF:M11394 Factor: Erg; motif: NACMGGAARTN 0.0231410841630215 4051 13 9 0.692307692307692 0.00222167366082449
TF TF:M02074_1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 1 0.0231410841630215 1005 18 6 0.333333333333333 0.00597014925373134
TF TF:M03970_1 Factor: ELK1; motif: ACCGGAAGTN; match class: 1 0.023174046807137 1097 17 6 0.352941176470588 0.00546946216955333
TF TF:M11438 Factor: SAP-1; motif: NTCGTAAATGCN 0.0232156231388393 5901 22 15 0.681818181818182 0.0025419420437214
TF TF:M08913 Factor: FLI-1; motif: NAYTTCCGGT 0.0232156231388393 8322 13 12 0.923076923076923 0.00144196106705119
TF TF:M11442 Factor: Net; motif: NACCGGAAGTN 0.0232156231388393 2012 23 9 0.391304347826087 0.00447316103379722
TF TF:M03988 Factor: FLI1; motif: ACCGGAARTN 0.0232156231388393 8318 13 12 0.923076923076923 0.00144265448425102
TF TF:M11400_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.0232156231388393 4201 23 13 0.565217391304348 0.00309450130921209
TF TF:M04691_1 Factor: Kaiso; motif: TCTCGCGAG; match class: 1 0.0232156231388393 10488 32 27 0.84375 0.00257437070938215
TF TF:M10956_1 Factor: isx; motif: NTCRTTAA; match class: 1 0.0232156231388393 3336 31 14 0.451612903225806 0.00419664268585132
TF TF:M10885_1 Factor: PRX-2; motif: NKCGTTAN; match class: 1 0.0232156231388393 1198 29 8 0.275862068965517 0.00667779632721202
TF TF:M10887_1 Factor: PRX-2; motif: NNCRTTAN; match class: 1 0.0232156231388393 1198 29 8 0.275862068965517 0.00667779632721202
TF TF:M01078_1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 1 0.0238898444413744 2448 32 12 0.375 0.00490196078431373
TF TF:M04826_1 Factor: p300; motif: ACNTCCG; match class: 1 0.0238898444413744 15260 32 32 1 0.00209698558322412
TF TF:M12121 Factor: ZNF449; motif: MMGCCCAACC 0.0273854384929476 856 4 3 0.75 0.00350467289719626
TF TF:M02058 Factor: SAP1A; motif: NCCGGAARYN 0.0274533503030991 842 23 6 0.260869565217391 0.00712589073634204
TF TF:M03972 Factor: ELK3; motif: ACCGGAAGTN 0.0278569935937867 1211 23 7 0.304347826086957 0.00578034682080925
TF TF:M02067_1 Factor: ER71; motif: ACCGGAARYN; match class: 1 0.0290009999005633 1619 18 7 0.388888888888889 0.00432365657813465
TF TF:M10999_1 Factor: LIM-1; motif: NNCGTTAN; match class: 1 0.0290798667347998 1266 29 8 0.275862068965517 0.00631911532385466
TF TF:M00144 Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM 0.0290798667347998 13205 32 30 0.9375 0.00227186671715259
TF TF:M09935_1 Factor: GABP-alpha; motif: NNNRCCGGAAGTGN; match class: 1 0.0291641468689795 1047 13 5 0.384615384615385 0.00477554918815664
TF TF:M01165 Factor: Elk-1; motif: RACCGGAAGTR 0.0291641468689795 7773 17 14 0.823529411764706 0.0018011063939277
TF TF:M00007 Factor: Elk-1; motif: NAAACMGGAAGTNCVH 0.0309989767879639 5873 25 16 0.64 0.00272433168738294
TF TF:M11531 Factor: E2F-2; motif: GCGCGCGCGYW 0.0309989767879639 13270 32 30 0.9375 0.00226073850791258
TF TF:M03976 Factor: ERG; motif: ACCGGAWATCCGGT 0.0309989767879639 12803 18 18 1 0.00140592048738577
TF TF:M02066 Factor: PEA3; motif: RCCGGAAGYN 0.031128301320504 7045 13 11 0.846153846153846 0.00156139105748758
TF TF:M11457 Factor: nerf; motif: NANGCGGAAGTR 0.0313679049869512 1082 13 5 0.384615384615385 0.00462107208872458
TF TF:M11404 Factor: Fli-1; motif: NACCGGAARTN 0.0313679049869512 8743 13 12 0.923076923076923 0.00137252659270273
TF TF:M08917 Factor: GABP-ALPHA; motif: RCCGGAARTNN 0.0333581606361167 2702 23 10 0.434782608695652 0.00370096225018505
TF TF:M11406 Factor: Pet-1; motif: NACCGGAAGTN 0.0350759537725779 1301 23 7 0.304347826086957 0.005380476556495
TF TF:M02067 Factor: ER71; motif: ACCGGAARYN 0.0350759537725779 5930 23 15 0.652173913043478 0.00252951096121417
TF TF:M02065_1 Factor: ER81; motif: RCCGGAARYN; match class: 1 0.0350759537725779 6749 19 14 0.736842105263158 0.00207438138983553
TF TF:M03987 Factor: FEV; motif: ACCGGAAGTN 0.0364521284615263 1318 23 7 0.304347826086957 0.00531107738998483
TF TF:M03965 Factor: EHF; motif: NACCCGGAAGTA 0.0364521284615263 389 20 4 0.2 0.0102827763496144
TF TF:M12165 Factor: BTEB2; motif: NCCACRCCCN 0.0364521284615263 4901 32 17 0.53125 0.00346867986125281
TF TF:M01163 Factor: Elk-1; motif: AACCGGAAGTR 0.0364914220896165 5260 23 14 0.608695652173913 0.0026615969581749
TF TF:M11530_1 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 0.0364914220896165 13449 32 30 0.9375 0.0022306491188936
TF TF:M00431_1 Factor: E2F-1; motif: TTTSGCGS; match class: 1 0.0364914220896165 2271 32 11 0.34375 0.00484368119771026
TF TF:M12154_1 Factor: Sp3; motif: NGCCACGCCCMCN; match class: 1 0.0364914220896165 274 28 4 0.142857142857143 0.0145985401459854
TF TF:M04750 Factor: GR; motif: RGRACATTNTGTYC 0.0367936577299106 5323 8 7 0.875 0.00131504790531655
TF TF:M11437 Factor: SAP-1; motif: NRCCGGAWGYN 0.0367936577299106 2788 23 10 0.434782608695652 0.00358680057388809
TF TF:M02053 Factor: ELF1; motif: NCCGGAARTN 0.0367936577299106 6033 23 15 0.652173913043478 0.00248632521133764
TF TF:M04869 Factor: Egr-1; motif: GCGCATGCG 0.0367936577299106 11232 22 20 0.909090909090909 0.00178062678062678
TF TF:M00428 Factor: E2F-1; motif: NKTSSCGC 0.0367936577299106 8947 32 24 0.75 0.00268246339555158
TF TF:M12238 Factor: DREF; motif: MTRTCGCGAYAK 0.0367936577299106 350 10 3 0.3 0.00857142857142857
TF TF:M00144_1 Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM; match class: 1 0.0372284519865348 7128 30 20 0.666666666666667 0.00280583613916947
TF TF:M11683 Factor: IRF-8; motif: NCGAAACCGAAACYN 0.0373708102799914 4690 13 9 0.692307692307692 0.00191897654584222
TF TF:M08423_1 Factor: TEF-3:ER81; motif: ACCGGAAATRCC; match class: 1 0.0375573833512178 654 13 4 0.307692307692308 0.00611620795107034
TF TF:M10625_1 Factor: Nkx3-2; motif: NTCGTTAN; match class: 1 0.037686901997961 1314 31 8 0.258064516129032 0.0060882800608828
TF TF:M11828 Factor: LRH-1; motif: TCAAGGTCRYGACCTTGR 0.037686901997961 10627 16 15 0.9375 0.00141149901195069
TF TF:M11448_1 Factor: Elf-1; motif: NANGCGGAAGTN; match class: 1 0.037686901997961 2324 32 11 0.34375 0.00473321858864028
TF TF:M11421 Factor: ER81; motif: NACCGGAAGTN 0.037686901997961 2341 23 9 0.391304347826087 0.00384451089278086
TF TF:M00736 Factor: E2F-1:DP-1; motif: TTTCSCGC 0.037686901997961 10390 32 26 0.8125 0.00250240615976901
TF TF:M11432_1 Factor: Elk-1; motif: NACMGGAAGTN; match class: 1 0.037686901997961 1525 27 8 0.296296296296296 0.00524590163934426
TF TF:M11684 Factor: IRF-8; motif: NYGAAACYGAAACTN 0.037686901997961 4664 11 8 0.727272727272727 0.00171526586620926
TF TF:M02068 Factor: etv3; motif: ACCGGAAGYN 0.037686901997961 3443 23 11 0.478260869565217 0.00319488817891374
TF TF:M09904_1 Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 0.037686901997961 2743 32 12 0.375 0.004374772147284
TF TF:M11056_1 Factor: Hey1; motif: NGCACGYGYN; match class: 1 0.037686901997961 663 6 3 0.5 0.00452488687782805
TF TF:M11530 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN 0.037686901997961 14593 32 31 0.96875 0.00212430617419311
TF TF:M02056_1 Factor: ELF4; motif: NCCGGAARTN; match class: 1 0.037686901997961 1291 18 6 0.333333333333333 0.00464756003098373
TF TF:M11541_1 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN; match class: 1 0.037686901997961 5493 8 7 0.875 0.00127434917167304
TF TF:M11415_1 Factor: GABP-alpha; motif: NRCCGGAAGTN; match class: 1 0.037686901997961 546 27 5 0.185185185185185 0.00915750915750916
TF TF:M00641_1 Factor: HSF; motif: TTCCMGARGYTTC; match class: 1 0.0378168935635099 387 10 3 0.3 0.00775193798449612
TF TF:M09966 Factor: Kaiso; motif: SARNYCTCGCGAGAN 0.0378168935635099 2356 32 11 0.34375 0.00466893039049236
TF TF:M08345_1 Factor: HOXB2:PEA3; motif: ACCGGAAATGRN; match class: 1 0.0393416298250025 2198 20 8 0.4 0.00363967242948135
TF TF:M11665 Factor: IRF-2; motif: NGAAASYGAAAS 0.0393416298250025 2396 11 6 0.545454545454545 0.00250417362270451
TF TF:M03558_1 Factor: P73; motif: GNNNRRRCNTGCMNNTSASN; match class: 1 0.0402021933102219 822 19 5 0.263157894736842 0.00608272506082725
TF TF:M11476_1 Factor: Tcfap2e; motif: TGCCCYNNGGCN; match class: 1 0.0402430166154583 244 16 3 0.1875 0.0122950819672131
TF TF:M11422_1 Factor: Erm; motif: NRCMGGAAGTN; match class: 1 0.0402430166154583 934 17 5 0.294117647058824 0.00535331905781585
TF TF:M02072 Factor: Pet-1; motif: ACCGGAWRTN 0.0402430166154583 2395 23 9 0.391304347826087 0.00375782881002088
TF TF:M03970 Factor: ELK1; motif: ACCGGAAGTN 0.0402430166154583 4782 23 13 0.565217391304348 0.0027185278126307
TF TF:M00979 Factor: Pax-6; motif: CTGACCTGGAACTM 0.0402430166154583 9690 17 15 0.882352941176471 0.00154798761609907
TF TF:M01660_1 Factor: GABP-alpha; motif: CTTCCK; match class: 1 0.0407049025358892 5133 32 17 0.53125 0.00331190337034872
TF TF:M08313_1 Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 0.0407049025358892 9721 17 15 0.882352941176471 0.00154305112642732
TF TF:M07140 Factor: Kaiso; motif: NTCTCGCGAGANYTN 0.0407049025358892 552 28 5 0.178571428571429 0.00905797101449275
TF TF:M11808 Factor: RAR-gamma; motif: NAGGTCANG 0.0407049025358892 2019 32 10 0.3125 0.00495294700346706
TF TF:M00736_1 Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 0.040956708223024 4639 32 16 0.5 0.00344901918516922
TF TF:M07612 Factor: PSF; motif: KWATCCGN 0.0415139108785217 5581 30 17 0.566666666666667 0.00304604909514424
TF TF:M11541 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN 0.0415139108785217 5751 8 7 0.875 0.00121717962093549
TF TF:M03791 Factor: GABPalpha_GABPbeta; motif: CTTCCKGY 0.0415139108785217 2969 23 10 0.434782608695652 0.00336813742000674
TF TF:M11018_1 Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 0.0415139108785217 15920 32 32 1 0.00201005025125628
TF TF:M11396_1 Factor: Erg; motif: NACCGGAARTN; match class: 1 0.0415139108785217 4963 13 9 0.692307692307692 0.00181341930284102
TF TF:M03971 Factor: ELK1; motif: NACTTCCGSCGGAAGYN 0.0415139108785217 11293 32 27 0.84375 0.00239086159567874
TF TF:M02059 Factor: ELK-1; motif: ACCGGAAGTN 0.0415139108785217 9423 13 12 0.923076923076923 0.00127347978350844
TF TF:M00430_1 Factor: E2F-1; motif: NTTSGCGG; match class: 1 0.0415139108785217 2524 31 11 0.354838709677419 0.0043581616481775
TF TF:M01752 Factor: ERG; motif: ACCGGAART 0.0419549794166826 9474 13 12 0.923076923076923 0.0012666244458518
TF TF:M08993 Factor: ZNF777; motif: GTCCGYCCCGTCSAACAAT 0.0419700861272997 10617 11 11 1 0.00103607422058962
TF TF:M11452_1 Factor: Elf-1; motif: NANGCGGAAGTR; match class: 1 0.0420546607486736 1696 32 9 0.28125 0.00530660377358491
TF TF:M10887 Factor: PRX-2; motif: NNCRTTAN 0.0420546607486736 5715 32 18 0.5625 0.0031496062992126
TF TF:M01167 Factor: SAP-1a; motif: NACCGGAAGTV 0.0420546607486736 1948 23 8 0.347826086956522 0.00410677618069815
TF TF:M10885 Factor: PRX-2; motif: NKCGTTAN 0.0420546607486736 5715 32 18 0.5625 0.0031496062992126
TF TF:M12172 Factor: LKLF; motif: NRCCACRCCCN 0.0458577112443835 2089 32 10 0.3125 0.00478697941598851
TF TF:M11430 Factor: PEA3; motif: NACCGGAAGTN 0.0459699216755769 10865 23 20 0.869565217391304 0.00184077312471238
TF TF:M11451_1 Factor: Elf-1; motif: NANCCGGAAGTN; match class: 1 0.0460444128122345 2112 32 10 0.3125 0.00473484848484848
TF TF:M00976_1 Factor: AhR,; motif: NRCGTGNGN; match class: 1 0.0460444128122345 1011 25 6 0.24 0.00593471810089021
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.0460444128122345 14873 32 31 0.96875 0.00208431385732535
TF TF:M02054 Factor: ELF2; motif: CCCGGAARYN 0.0460444128122345 3066 23 10 0.434782608695652 0.00326157860404436
TF TF:M10098_1 Factor: DP-1; motif: NRNNGGCGGGAANN; match class: 1 0.0460444128122345 2168 3 3 1 0.00138376383763838
TF TF:M11449 Factor: Elf-1; motif: NANCCGGAAGTN 0.0460444128122345 4305 23 12 0.521739130434783 0.00278745644599303
TF TF:M12205 Factor: GATA-5; motif: WGATAACGATCT 0.0460444128122345 260 17 3 0.176470588235294 0.0115384615384615
TF TF:M02011 Factor: HES-1; motif: GSCACGMGMC 0.0460444128122345 4259 32 15 0.46875 0.00352195351021367
TF TF:M07100_1 Factor: HSF1; motif: NTTCTRGAANNTTCY; match class: 1 0.0460444128122345 514 9 3 0.333333333333333 0.00583657587548638
TF TF:M11659 Factor: HSF4; motif: NGAANRTTCTAGAAN 0.0460444128122345 329 29 4 0.137931034482759 0.0121580547112462
TF TF:M11413 Factor: ER71; motif: NACCGGAARTN 0.0460444128122345 2111 13 6 0.461538461538462 0.00284225485551871
TF TF:M03990 Factor: GABPA; motif: ACCGGAAGTN 0.0462285849447181 5258 27 15 0.555555555555556 0.00285279573982503
TF TF:M11439 Factor: Net; motif: NRCCGGAAGTN 0.0462988429503099 2568 27 10 0.37037037037037 0.00389408099688474
TF TF:M03812 Factor: arnt; motif: CACGYA 0.0462988429503099 4330 23 12 0.521739130434783 0.00277136258660508
TF TF:M12184_1 Factor: KLF14; motif: NRCCACGCCCMCN; match class: 1 0.0462988429503099 350 28 4 0.142857142857143 0.0114285714285714
TF TF:M11434_1 Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 0.0462988429503099 2935 32 12 0.375 0.0040885860306644
TF TF:M11657 Factor: HSF1; motif: NGAANRTTCKAGAAN 0.0462988429503099 337 29 4 0.137931034482759 0.0118694362017804
TF TF:M11400 Factor: Fli-1; motif: NACCGGAARTN 0.0464349223454586 9946 20 17 0.85 0.00170922984114217
TF TF:M01165_1 Factor: Elk-1; motif: RACCGGAAGTR; match class: 1 0.0464349223454586 2185 17 7 0.411764705882353 0.00320366132723112
TF TF:M07226_1 Factor: SP1; motif: NCCCCKCCCCC; match class: 1 0.0465360548642145 3915 4 4 1 0.00102171136653895
TF TF:M03975 Factor: ERG; motif: ACCGGAARTN 0.0465360548642145 10002 20 17 0.85 0.0016996600679864
TF TF:M00716 Factor: ZF5; motif: GSGCGCGR 0.0465360548642145 16103 32 32 1 0.0019872073526672
TF TF:M02012 Factor: HIF-1alpha; motif: NCACGT 0.0465360548642145 6648 11 9 0.818181818181818 0.00135379061371841
TF TF:M10974 Factor: LHX9; motif: NTCGTTAN 0.0465360548642145 253 18 3 0.166666666666667 0.0118577075098814
TF TF:M10980 Factor: lhx6; motif: CTCGTTAR 0.0465360548642145 253 18 3 0.166666666666667 0.0118577075098814
TF TF:M04457 Factor: ESRRA; motif: AAGGTCATNCAAGGTCA 0.0465360548642145 3550 24 11 0.458333333333333 0.00309859154929577
TF TF:M01253 Factor: CNOT3; motif: GGCCGCGSSS 0.0465360548642145 3926 4 4 1 0.00101884870096791
TF TF:M01214_1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 0.0465360548642145 2176 13 6 0.461538461538462 0.00275735294117647
TF TF:M12166_1 Factor: CPBP; motif: NGCCACGCCCN; match class: 1 0.0465360548642145 162 28 3 0.107142857142857 0.0185185185185185
TF TF:M02055_1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 0.0465360548642145 2176 13 6 0.461538461538462 0.00275735294117647
TF TF:M08208_1 Factor: E2F-3:FOXI1; motif: NGACACCGCGCCCAC; match class: 1 0.0465360548642145 7127 14 11 0.785714285714286 0.0015434264066227
TF TF:M02068_1 Factor: etv3; motif: ACCGGAAGYN; match class: 1 0.0468921542475484 613 17 4 0.235294117647059 0.0065252854812398
TF TF:M11877 Factor: pax-2; motif: NCGTCACGCNYSRNYGCNYN 0.0474649005987092 11523 32 27 0.84375 0.00234313980734184
TF TF:M09894 Factor: E2F-4; motif: SNGGGCGGGAANN 0.047737567616139 16194 32 32 1 0.00197604050883043
TF TF:M02044_1 Factor: YY1; motif: GCCGCCATTTTG; match class: 1 0.047737567616139 1198 30 7 0.233333333333333 0.00584307178631052
TF TF:M12275_1 Factor: YY1; motif: NGCCGCCATYTTGN; match class: 1 0.047737567616139 1600 12 5 0.416666666666667 0.003125
TF TF:M04698 Factor: GABP-alpha; motif: CACTTCCGG 0.047737567616139 3196 23 10 0.434782608695652 0.00312891113892365
TF TF:M11531_1 Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 0.047737567616139 12351 32 28 0.875 0.00226702291312444
TF TF:M08526_1 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 0.047737567616139 14997 32 31 0.96875 0.0020670800826832
TF TF:M01163_1 Factor: Elk-1; motif: AACCGGAAGTR; match class: 1 0.047737567616139 1086 17 5 0.294117647058824 0.00460405156537753
TF TF:M11603_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.047737567616139 13184 22 21 0.954545454545455 0.00159283980582524
TF TF:M09817_1 Factor: PAX5; motif: RNGCGTGACCNN; match class: 1 0.047737567616139 6170 31 18 0.580645161290323 0.00291734197730956
TF TF:M08377 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN 0.047737567616139 11275 20 18 0.9 0.00159645232815965
TF TF:M10999 Factor: LIM-1; motif: NNCGTTAN 0.047737567616139 5894 32 18 0.5625 0.00305395317271802
TF TF:M02071 Factor: ETV7; motif: NCCGGAANNN 0.047737567616139 10116 29 23 0.793103448275862 0.00227362593910637
TF TF:M02073_1 Factor: Fli-1; motif: ACCGGAAGYN; match class: 1 0.047737567616139 1488 8 4 0.5 0.00268817204301075
TF TF:M04008 Factor: HSF1; motif: TTCTAGAAYNTTC 0.047737567616139 358 29 4 0.137931034482759 0.0111731843575419
TF TF:M10514 Factor: GLI4; motif: RGGCCTTGAATGCCANGCYMA 0.047737567616139 12698 20 19 0.95 0.00149629862970547
TF TF:M08295_1 Factor: FOXO1A:Elf-1; motif: NAGAAAACCGAANM; match class: 1 0.047737567616139 4997 26 14 0.538461538461538 0.00280168100860516
TF TF:M11433_1 Factor: Elk-1; motif: NRCCGGAAGTN; match class: 1 0.047737567616139 2261 17 7 0.411764705882353 0.00309597523219814
TF TF:M00938_1 Factor: E2F-1; motif: TTGGCGCGRAANNGNM; match class: 1 0.047737567616139 2573 32 11 0.34375 0.00427516517683638
TF TF:M03921_1 Factor: SP3; motif: NCCACGCCCMC; match class: 1 0.0480322191641672 638 28 5 0.178571428571429 0.00783699059561128
TF TF:M00716_1 Factor: ZF5; motif: GSGCGCGR; match class: 1 0.0480322191641672 14106 26 25 0.961538461538462 0.00177229547710194
TF TF:M11420 Factor: ER81; motif: NACCGGAAGTN 0.0486442932807689 3210 23 10 0.434782608695652 0.00311526479750779
TF TF:M10438 Factor: ZF5; motif: GGSGCGCGS 0.0496808888980586 16228 32 32 1 0.00197190041902884
WP WP:WP4396 Nonalcoholic fatty liver disease 7.43878201811562e-07 159 32 9 0.28125 0.0566037735849057
WP WP:WP111 Electron Transport Chain (OXPHOS system in mitochondria) 6.47824524893474e-06 105 32 7 0.21875 0.0666666666666667
WP WP:WP4922 Mitochondrial CIV Assembly 0.000266486831436956 35 32 4 0.125 0.114285714285714
WP WP:WP623 Oxidative phosphorylation 0.00114707679698532 62 28 4 0.142857142857143 0.0645161290322581
WP WP:WP411 mRNA Processing 0.0019761942311637 133 30 5 0.166666666666667 0.037593984962406
WP WP:WP3888 VEGFA-VEGFR2 Signaling Pathway 0.00666077303975642 437 4 3 0.75 0.0068649885583524
WP WP:WP15 Selenium Micronutrient Network 0.0112854467906894 91 19 3 0.157894736842105 0.032967032967033
WP WP:WP2884 NRF2 pathway 0.0151975742835934 145 14 3 0.214285714285714 0.0206896551724138

pEpi38 transcription factor target enrichment of top program genes

TF enrichment of pEpi38
Possible regulators of activation of pEpi38 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.