pEpi30 program activity among Epithelial cells

Activation of pEpi30
pEpi30 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi30 by different cell subtypes
pEpi30 gene program activation among cells of different subtypes (Epithelial cells).

pEpi30 top program genes

Top genes of pEpi30 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi30 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi30
pEpi30 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0009615 response to virus 5.87220596131211e-25 364 64 26 0.40625 0.0714285714285714
GO:BP GO:0071357 cellular response to type I interferon 5.87220596131211e-25 96 46 17 0.369565217391304 0.177083333333333
GO:BP GO:0060337 type I interferon signaling pathway 5.87220596131211e-25 95 46 17 0.369565217391304 0.178947368421053
GO:BP GO:0034340 response to type I interferon 8.56374579581033e-25 101 46 17 0.369565217391304 0.168316831683168
GO:BP GO:0098542 defense response to other organism 8.92061125237136e-23 1218 58 34 0.586206896551724 0.0279146141215107
GO:BP GO:0045087 innate immune response 1.18532182470412e-21 998 58 31 0.53448275862069 0.031062124248497
GO:BP GO:0140546 defense response to symbiont 5.86714916876982e-21 267 63 21 0.333333333333333 0.0786516853932584
GO:BP GO:0051607 defense response to virus 5.86714916876982e-21 267 63 21 0.333333333333333 0.0786516853932584
GO:BP GO:0043207 response to external biotic stimulus 9.00175788354715e-21 1594 64 37 0.578125 0.0232120451693852
GO:BP GO:0051707 response to other organism 9.00175788354715e-21 1592 64 37 0.578125 0.0232412060301508
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 9.5566234581332e-21 2255 46 35 0.760869565217391 0.0155210643015521
GO:BP GO:0009607 response to biotic stimulus 1.50007243546692e-20 1626 64 37 0.578125 0.0227552275522755
GO:BP GO:0006955 immune response 1.15411350007843e-19 2311 58 39 0.672413793103448 0.0168758113370835
GO:BP GO:0019221 cytokine-mediated signaling pathway 1.9827232031547e-19 810 63 28 0.444444444444444 0.0345679012345679
GO:BP GO:0006952 defense response 9.19252782283776e-19 1818 58 35 0.603448275862069 0.0192519251925193
GO:BP GO:0034097 response to cytokine 3.16159344522819e-18 1226 58 30 0.517241379310345 0.0244698205546493
GO:BP GO:0071345 cellular response to cytokine stimulus 4.89482444212374e-18 1132 58 29 0.5 0.0256183745583039
GO:BP GO:0048525 negative regulation of viral process 1.06599644886536e-16 94 55 13 0.236363636363636 0.138297872340426
GO:BP GO:0016032 viral process 1.32194165905175e-16 942 58 26 0.448275862068966 0.0276008492569002
GO:BP GO:0002376 immune system process 2.10536696361375e-16 3278 58 41 0.706896551724138 0.0125076266015863
GO:BP GO:0045088 regulation of innate immune response 2.20256191958159e-16 309 41 16 0.390243902439024 0.0517799352750809
GO:BP GO:0019079 viral genome replication 3.49621427754202e-16 131 58 14 0.241379310344828 0.106870229007634
GO:BP GO:0002252 immune effector process 3.97016417054545e-16 1309 55 28 0.509090909090909 0.0213903743315508
GO:BP GO:0002831 regulation of response to biotic stimulus 4.40305583661259e-16 415 55 19 0.345454545454545 0.0457831325301205
GO:BP GO:0045071 negative regulation of viral genome replication 4.40305583661259e-16 54 55 11 0.2 0.203703703703704
GO:BP GO:0044403 biological process involved in symbiotic interaction 4.40305583661259e-16 1001 58 26 0.448275862068966 0.025974025974026
GO:BP GO:0050792 regulation of viral process 7.91678051867744e-16 192 55 15 0.272727272727273 0.078125
GO:BP GO:0045069 regulation of viral genome replication 1.08170469762812e-15 84 55 12 0.218181818181818 0.142857142857143
GO:BP GO:1903900 regulation of viral life cycle 1.08170469762812e-15 153 55 14 0.254545454545455 0.0915032679738562
GO:BP GO:0043903 regulation of biological process involved in symbiotic interaction 1.6567773342389e-15 203 55 15 0.272727272727273 0.0738916256157636
GO:BP GO:0002682 regulation of immune system process 1.31551805850701e-14 1617 64 31 0.484375 0.0191713048855906
GO:BP GO:0034341 response to interferon-gamma 7.45305192507312e-14 196 58 14 0.241379310344828 0.0714285714285714
GO:BP GO:0019058 viral life cycle 6.72065279788078e-13 353 58 16 0.275862068965517 0.0453257790368272
GO:BP GO:0009605 response to external stimulus 6.75639009501267e-13 2944 46 31 0.673913043478261 0.0105298913043478
GO:BP GO:0050776 regulation of immune response 7.28968682015211e-13 996 64 24 0.375 0.0240963855421687
GO:BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 9.43037679384241e-13 75 22 8 0.363636363636364 0.106666666666667
GO:BP GO:0045824 negative regulation of innate immune response 1.04821213165519e-12 66 41 9 0.219512195121951 0.136363636363636
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 1.52974864430859e-12 80 22 8 0.363636363636364 0.1
GO:BP GO:0006950 response to stress 2.95600489926784e-12 4170 55 39 0.709090909090909 0.00935251798561151
GO:BP GO:0031347 regulation of defense response 4.45876164808473e-12 704 55 19 0.345454545454545 0.0269886363636364
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 8.26462412857789e-12 99 22 8 0.363636363636364 0.0808080808080808
GO:BP GO:0002832 negative regulation of response to biotic stimulus 9.74974253901445e-12 100 52 10 0.192307692307692 0.1
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 4.14480594586686e-11 88 46 9 0.195652173913043 0.102272727272727
GO:BP GO:0050777 negative regulation of immune response 3.13414057585553e-10 157 64 11 0.171875 0.0700636942675159
GO:BP GO:0071346 cellular response to interferon-gamma 3.21991921225238e-10 175 58 11 0.189655172413793 0.0628571428571429
GO:BP GO:0071310 cellular response to organic substance 3.5344348152389e-10 2776 34 23 0.676470588235294 0.00828530259365994
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 7.07708870027977e-10 174 22 8 0.363636363636364 0.0459770114942529
GO:BP GO:0007166 cell surface receptor signaling pathway 8.9291779686153e-10 3210 58 33 0.568965517241379 0.0102803738317757
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 9.74292869378267e-10 182 22 8 0.363636363636364 0.043956043956044
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 1.466637452349e-09 192 22 8 0.363636363636364 0.0416666666666667
GO:BP GO:0002684 positive regulation of immune system process 1.58871788841467e-09 1065 64 21 0.328125 0.0197183098591549
GO:BP GO:0050778 positive regulation of immune response 2.43660913054969e-09 753 64 18 0.28125 0.0239043824701195
GO:BP GO:0032101 regulation of response to external stimulus 3.73077087131093e-09 1051 55 19 0.345454545454545 0.0180780209324453
GO:BP GO:0045089 positive regulation of innate immune response 5.85269183613625e-09 216 34 9 0.264705882352941 0.0416666666666667
GO:BP GO:0002683 negative regulation of immune system process 5.99070902330294e-09 420 64 14 0.21875 0.0333333333333333
GO:BP GO:0019882 antigen processing and presentation 6.35947820692975e-09 234 22 8 0.363636363636364 0.0341880341880342
GO:BP GO:0070887 cellular response to chemical stimulus 1.91253432338679e-08 3393 34 23 0.676470588235294 0.00677866195107574
GO:BP GO:0002833 positive regulation of response to biotic stimulus 1.99194016217169e-08 250 34 9 0.264705882352941 0.036
GO:BP GO:0010033 response to organic substance 2.07378476182373e-08 3412 34 23 0.676470588235294 0.00674091441969519
GO:BP GO:0035456 response to interferon-beta 2.17815290496941e-08 30 27 5 0.185185185185185 0.166666666666667
GO:BP GO:0035455 response to interferon-alpha 3.13896703094636e-08 23 38 5 0.131578947368421 0.217391304347826
GO:BP GO:0031348 negative regulation of defense response 5.20106354270042e-08 246 52 10 0.192307692307692 0.040650406504065
GO:BP GO:0080134 regulation of response to stress 9.37461461306836e-08 1443 55 20 0.363636363636364 0.0138600138600139
GO:BP GO:0002483 antigen processing and presentation of endogenous peptide antigen 1.84767889251157e-07 19 22 4 0.181818181818182 0.210526315789474
GO:BP GO:0038061 NIK/NF-kappaB signaling 2.50021926793381e-07 194 40 8 0.2 0.0412371134020619
GO:BP GO:0002698 negative regulation of immune effector process 3.76577618451054e-07 125 64 8 0.125 0.064
GO:BP GO:0031349 positive regulation of defense response 4.38657364857962e-07 362 34 9 0.264705882352941 0.0248618784530387
GO:BP GO:0019883 antigen processing and presentation of endogenous antigen 6.67016518742199e-07 26 22 4 0.181818181818182 0.153846153846154
GO:BP GO:1903901 negative regulation of viral life cycle 9.530318391382e-07 26 24 4 0.166666666666667 0.153846153846154
GO:BP GO:0048583 regulation of response to stimulus 1.40949527263749e-06 4278 58 33 0.568965517241379 0.00771388499298738
GO:BP GO:0002520 immune system development 1.49903736142822e-06 1020 64 17 0.265625 0.0166666666666667
GO:BP GO:0002697 regulation of immune effector process 1.66357061971688e-06 461 64 12 0.1875 0.0260303687635575
GO:BP GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent 2.24916476337485e-06 8 22 3 0.136363636363636 0.375
GO:BP GO:1902036 regulation of hematopoietic stem cell differentiation 2.4467650747866e-06 75 28 5 0.178571428571429 0.0666666666666667
GO:BP GO:0001817 regulation of cytokine production 2.4467650747866e-06 806 64 15 0.234375 0.0186104218362283
GO:BP GO:0000209 protein polyubiquitination 2.85320806109646e-06 342 14 6 0.428571428571429 0.0175438596491228
GO:BP GO:0032103 positive regulation of response to external stimulus 2.94958594349272e-06 513 40 10 0.25 0.0194931773879142
GO:BP GO:0048584 positive regulation of response to stimulus 3.28994178121961e-06 2344 64 25 0.390625 0.0106655290102389
GO:BP GO:0006521 regulation of cellular amino acid metabolic process 3.30907698980361e-06 64 14 4 0.285714285714286 0.0625
GO:BP GO:0033209 tumor necrosis factor-mediated signaling pathway 3.71235368875727e-06 177 14 5 0.357142857142857 0.0282485875706215
GO:BP GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 3.75902307866772e-06 13 16 3 0.1875 0.230769230769231
GO:BP GO:0001816 cytokine production 4.0525689383147e-06 844 64 15 0.234375 0.0177725118483412
GO:BP GO:0050691 regulation of defense response to virus by host 4.30690298752179e-06 43 55 5 0.0909090909090909 0.116279069767442
GO:BP GO:0032102 negative regulation of response to external stimulus 4.40469783640439e-06 406 52 10 0.192307692307692 0.0246305418719212
GO:BP GO:1901532 regulation of hematopoietic progenitor cell differentiation 5.0334902510945e-06 89 28 5 0.178571428571429 0.0561797752808989
GO:BP GO:0019941 modification-dependent protein catabolic process 5.0334902510945e-06 662 14 7 0.5 0.0105740181268882
GO:BP GO:0060218 hematopoietic stem cell differentiation 5.0334902510945e-06 89 28 5 0.178571428571429 0.0561797752808989
GO:BP GO:0048585 negative regulation of response to stimulus 5.41282429839786e-06 1733 64 21 0.328125 0.0121177149451818
GO:BP GO:0043632 modification-dependent macromolecule catabolic process 5.50377807724708e-06 673 14 7 0.5 0.0104011887072808
GO:BP GO:0048519 negative regulation of biological process 6.19036891972899e-06 5757 35 26 0.742857142857143 0.00451624109779399
GO:BP GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 6.40943540809004e-06 78 14 4 0.285714285714286 0.0512820512820513
GO:BP GO:0033238 regulation of cellular amine metabolic process 7.75997065651194e-06 82 14 4 0.285714285714286 0.0487804878048781
GO:BP GO:0031145 anaphase-promoting complex-dependent catabolic process 8.87487692550151e-06 85 14 4 0.285714285714286 0.0470588235294118
GO:BP GO:0052548 regulation of endopeptidase activity 9.06073950119172e-06 437 41 9 0.219512195121951 0.0205949656750572
GO:BP GO:0051603 proteolysis involved in cellular protein catabolic process 1.07493337222719e-05 750 14 7 0.5 0.00933333333333333
GO:BP GO:0042221 response to chemical 1.10963569932955e-05 4781 34 23 0.676470588235294 0.0048107090566827
GO:BP GO:0030097 hemopoiesis 1.15277799540286e-05 928 64 15 0.234375 0.0161637931034483
GO:BP GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 1.31834232575006e-05 95 14 4 0.285714285714286 0.0421052631578947
GO:BP GO:0052547 regulation of peptidase activity 1.36933814521171e-05 467 14 6 0.428571428571429 0.012847965738758
GO:BP GO:2000736 regulation of stem cell differentiation 1.5640424325275e-05 115 28 5 0.178571428571429 0.0434782608695652
GO:BP GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 1.70224051582327e-05 102 14 4 0.285714285714286 0.0392156862745098
GO:BP GO:0050896 response to stimulus 1.7072329576493e-05 9407 58 48 0.827586206896552 0.00510258318273626
GO:BP GO:0044257 cellular protein catabolic process 1.70939821058332e-05 813 14 7 0.5 0.00861008610086101
GO:BP GO:0048534 hematopoietic or lymphoid organ development 1.76669267258603e-05 966 64 15 0.234375 0.015527950310559
GO:BP GO:0002704 negative regulation of leukocyte mediated immunity 1.76669267258603e-05 51 64 5 0.078125 0.0980392156862745
GO:BP GO:0070498 interleukin-1-mediated signaling pathway 1.82205962523218e-05 105 14 4 0.285714285714286 0.0380952380952381
GO:BP GO:0060071 Wnt signaling pathway, planar cell polarity pathway 2.17515067261669e-05 110 14 4 0.285714285714286 0.0363636363636364
GO:BP GO:0032479 regulation of type I interferon production 2.19622743719551e-05 130 27 5 0.185185185185185 0.0384615384615385
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 2.21408051219186e-05 111 14 4 0.285714285714286 0.036036036036036
GO:BP GO:0032606 type I interferon production 2.23958901513035e-05 131 27 5 0.185185185185185 0.0381679389312977
GO:BP GO:0002223 stimulatory C-type lectin receptor signaling pathway 2.25371384738604e-05 112 14 4 0.285714285714286 0.0357142857142857
GO:BP GO:0006508 proteolysis 2.31145179246637e-05 1836 14 9 0.642857142857143 0.00490196078431373
GO:BP GO:1902750 negative regulation of cell cycle G2/M phase transition 2.31145179246637e-05 113 14 4 0.285714285714286 0.0353982300884956
GO:BP GO:0090175 regulation of establishment of planar polarity 2.33092561644293e-05 114 14 4 0.285714285714286 0.0350877192982456
GO:BP GO:0140289 protein mono-ADP-ribosylation 2.33092561644293e-05 12 35 3 0.0857142857142857 0.25
GO:BP GO:0010629 negative regulation of gene expression 2.33092561644293e-05 1460 40 14 0.35 0.00958904109589041
GO:BP GO:0002244 hematopoietic progenitor cell differentiation 2.33092561644293e-05 172 38 6 0.157894736842105 0.0348837209302326
GO:BP GO:0002220 innate immune response activating cell surface receptor signaling pathway 2.3566843537693e-05 115 14 4 0.285714285714286 0.0347826086956522
GO:BP GO:0002758 innate immune response-activating signal transduction 2.41926803527194e-05 116 14 4 0.285714285714286 0.0344827586206897
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 2.48293112148872e-05 117 14 4 0.285714285714286 0.0341880341880342
GO:BP GO:0016567 protein ubiquitination 2.71497699232383e-05 892 14 7 0.5 0.007847533632287
GO:BP GO:0007165 signal transduction 2.81161656535494e-05 6309 58 38 0.655172413793103 0.00602314154382628
GO:BP GO:0002218 activation of innate immune response 3.14366180771838e-05 144 27 5 0.185185185185185 0.0347222222222222
GO:BP GO:0046597 negative regulation of viral entry into host cell 3.44879639737754e-05 20 24 3 0.125 0.15
GO:BP GO:0046596 regulation of viral entry into host cell 3.46475491184673e-05 43 40 4 0.1 0.0930232558139535
GO:BP GO:0050688 regulation of defense response to virus 3.46475491184673e-05 71 55 5 0.0909090909090909 0.0704225352112676
GO:BP GO:0007164 establishment of tissue polarity 3.46475491184673e-05 130 14 4 0.285714285714286 0.0307692307692308
GO:BP GO:0001736 establishment of planar polarity 3.46475491184673e-05 130 14 4 0.285714285714286 0.0307692307692308
GO:BP GO:0071356 cellular response to tumor necrosis factor 3.46475491184673e-05 306 14 5 0.357142857142857 0.0163398692810458
GO:BP GO:0002230 positive regulation of defense response to virus by host 4.18016933855154e-05 33 55 4 0.0727272727272727 0.121212121212121
GO:BP GO:0032446 protein modification by small protein conjugation 4.41692342316726e-05 973 14 7 0.5 0.00719424460431655
GO:BP GO:0030163 protein catabolic process 4.41692342316726e-05 974 14 7 0.5 0.00718685831622177
GO:BP GO:0034612 response to tumor necrosis factor 4.84507115405688e-05 331 14 5 0.357142857142857 0.0151057401812689
GO:BP GO:0023052 signaling 5.95412223328713e-05 6810 58 39 0.672413793103448 0.00572687224669604
GO:BP GO:0052372 modulation by symbiont of entry into host 5.95412223328713e-05 50 40 4 0.1 0.08
GO:BP GO:0090263 positive regulation of canonical Wnt signaling pathway 5.95412223328713e-05 151 14 4 0.285714285714286 0.0264900662251656
GO:BP GO:0035567 non-canonical Wnt signaling pathway 5.95412223328713e-05 151 14 4 0.285714285714286 0.0264900662251656
GO:BP GO:0001738 morphogenesis of a polarized epithelium 6.04129971696553e-05 152 14 4 0.285714285714286 0.0263157894736842
GO:BP GO:0007154 cell communication 6.34992977388332e-05 6829 58 39 0.672413793103448 0.00571093864401816
GO:BP GO:0006511 ubiquitin-dependent protein catabolic process 6.7727493759723e-05 655 14 6 0.428571428571429 0.00916030534351145
GO:BP GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 7.19902966491893e-05 16 40 3 0.075 0.1875
GO:BP GO:0044106 cellular amine metabolic process 7.69700068907376e-05 163 14 4 0.285714285714286 0.0245398773006135
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 7.73752560891901e-05 3241 41 20 0.48780487804878 0.00617093489663684
GO:BP GO:0038095 Fc-epsilon receptor signaling pathway 8.35805554739481e-05 167 14 4 0.285714285714286 0.0239520958083832
GO:BP GO:0002716 negative regulation of natural killer cell mediated immunity 8.44323810106553e-05 17 40 3 0.075 0.176470588235294
GO:BP GO:0009308 amine metabolic process 8.44323810106553e-05 168 14 4 0.285714285714286 0.0238095238095238
GO:BP GO:0002253 activation of immune response 0.000103972757173643 568 56 10 0.178571428571429 0.0176056338028169
GO:BP GO:0030177 positive regulation of Wnt signaling pathway 0.000118622925791239 184 14 4 0.285714285714286 0.0217391304347826
GO:BP GO:2000027 regulation of animal organ morphogenesis 0.000118622925791239 184 14 4 0.285714285714286 0.0217391304347826
GO:BP GO:0071347 cellular response to interleukin-1 0.000120398516766146 185 14 4 0.285714285714286 0.0216216216216216
GO:BP GO:0090090 negative regulation of canonical Wnt signaling pathway 0.00012480681290164 187 14 4 0.285714285714286 0.0213903743315508
GO:BP GO:0043488 regulation of mRNA stability 0.000134452105421995 191 14 4 0.285714285714286 0.0209424083769634
GO:BP GO:0001911 negative regulation of leukocyte mediated cytotoxicity 0.000134452105421995 20 40 3 0.075 0.15
GO:BP GO:0030162 regulation of proteolysis 0.000136439346289524 752 14 6 0.428571428571429 0.00797872340425532
GO:BP GO:0070647 protein modification by small protein conjugation or removal 0.000136908851281843 1184 14 7 0.5 0.00591216216216216
GO:BP GO:0010565 regulation of cellular ketone metabolic process 0.000139753136711855 194 14 4 0.285714285714286 0.0206185567010309
GO:BP GO:0001959 regulation of cytokine-mediated signaling pathway 0.000147536626165311 184 51 6 0.117647058823529 0.0326086956521739
GO:BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 0.00015187279680842 434 14 5 0.357142857142857 0.0115207373271889
GO:BP GO:0043487 regulation of RNA stability 0.000157740874686127 201 14 4 0.285714285714286 0.0199004975124378
GO:BP GO:0050852 T cell receptor signaling pathway 0.000163010283068187 203 14 4 0.285714285714286 0.0197044334975369
GO:BP GO:0044265 cellular macromolecule catabolic process 0.000169292521971172 1231 14 7 0.5 0.00568643379366369
GO:BP GO:0070663 regulation of leukocyte proliferation 0.000169292521971172 251 58 7 0.120689655172414 0.0278884462151394
GO:BP GO:0060334 regulation of interferon-gamma-mediated signaling pathway 0.000169838835900729 26 34 3 0.0882352941176471 0.115384615384615
GO:BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 0.000169838835900729 207 14 4 0.285714285714286 0.0193236714975845
GO:BP GO:1901224 positive regulation of NIK/NF-kappaB signaling 0.000169838835900729 68 40 4 0.1 0.0588235294117647
GO:BP GO:0060330 regulation of response to interferon-gamma 0.000169838835900729 26 34 3 0.0882352941176471 0.115384615384615
GO:BP GO:0002707 negative regulation of lymphocyte mediated immunity 0.000174536711742578 43 64 4 0.0625 0.0930232558139535
GO:BP GO:0071456 cellular response to hypoxia 0.000183251806400344 212 14 4 0.285714285714286 0.0188679245283019
GO:BP GO:0061013 regulation of mRNA catabolic process 0.00018559700927254 213 14 4 0.285714285714286 0.0187793427230047
GO:BP GO:0070555 response to interleukin-1 0.000191439870786096 215 14 4 0.285714285714286 0.0186046511627907
GO:BP GO:0009892 negative regulation of metabolic process 0.000195179955651212 3479 41 20 0.48780487804878 0.00574877838459327
GO:BP GO:0060759 regulation of response to cytokine stimulus 0.000197578505183813 197 51 6 0.117647058823529 0.0304568527918782
GO:BP GO:0030178 negative regulation of Wnt signaling pathway 0.000198733095489753 218 14 4 0.285714285714286 0.018348623853211
GO:BP GO:0031342 negative regulation of cell killing 0.00020793012534358 24 40 3 0.075 0.125
GO:BP GO:0036294 cellular response to decreased oxygen levels 0.000211067844045645 222 14 4 0.285714285714286 0.018018018018018
GO:BP GO:1902749 regulation of cell cycle G2/M phase transition 0.000213633986236666 223 14 4 0.285714285714286 0.0179372197309417
GO:BP GO:0051716 cellular response to stimulus 0.000229273530301957 7781 36 28 0.777777777777778 0.00359850918905025
GO:BP GO:0010498 proteasomal protein catabolic process 0.000242417042428114 491 14 5 0.357142857142857 0.010183299389002
GO:BP GO:0048523 negative regulation of cellular process 0.000268353838299503 5139 64 34 0.53125 0.0066160731659856
GO:BP GO:0038093 Fc receptor signaling pathway 0.000268353838299503 238 14 4 0.285714285714286 0.0168067226890756
GO:BP GO:0071453 cellular response to oxygen levels 0.000275809799779765 240 14 4 0.285714285714286 0.0166666666666667
GO:BP GO:1901565 organonitrogen compound catabolic process 0.000284468467399086 1358 14 7 0.5 0.00515463917525773
GO:BP GO:0016553 base conversion or substitution editing 0.000293138022109006 20 55 3 0.0545454545454545 0.15
GO:BP GO:0032656 regulation of interleukin-13 production 0.000315713891070695 18 63 3 0.0476190476190476 0.166666666666667
GO:BP GO:0002507 tolerance induction 0.000348993375642038 29 40 3 0.075 0.103448275862069
GO:BP GO:0048863 stem cell differentiation 0.000356460360151258 258 14 4 0.285714285714286 0.0155038759689922
GO:BP GO:1901991 negative regulation of mitotic cell cycle phase transition 0.000375186391335775 262 14 4 0.285714285714286 0.0152671755725191
GO:BP GO:0032480 negative regulation of type I interferon production 0.000375186391335775 46 26 3 0.115384615384615 0.0652173913043478
GO:BP GO:0000086 G2/M transition of mitotic cell cycle 0.000389640681615061 265 14 4 0.285714285714286 0.0150943396226415
GO:BP GO:0042180 cellular ketone metabolic process 0.000423043723220248 271 14 4 0.285714285714286 0.014760147601476
GO:BP GO:0032616 interleukin-13 production 0.000423190098389959 20 63 3 0.0476190476190476 0.15
GO:BP GO:0002009 morphogenesis of an epithelium 0.000423190098389959 560 14 5 0.357142857142857 0.00892857142857143
GO:BP GO:0006471 protein ADP-ribosylation 0.000431816551050037 36 35 3 0.0857142857142857 0.0833333333333333
GO:BP GO:0009057 macromolecule catabolic process 0.00044371810050969 1468 14 7 0.5 0.00476839237057221
GO:BP GO:1901988 negative regulation of cell cycle phase transition 0.000475061972390614 281 14 4 0.285714285714286 0.0142348754448399
GO:BP GO:0044839 cell cycle G2/M phase transition 0.000485941648957126 283 14 4 0.285714285714286 0.0141342756183746
GO:BP GO:0009967 positive regulation of signal transduction 0.000512894761508448 1598 43 13 0.302325581395349 0.0081351689612015
GO:BP GO:0001818 negative regulation of cytokine production 0.000525075740984843 381 64 8 0.125 0.020997375328084
GO:BP GO:0009968 negative regulation of signal transduction 0.000537751712758198 1364 31 10 0.32258064516129 0.00733137829912024
GO:BP GO:0016579 protein deubiquitination 0.000538217760944783 292 14 4 0.285714285714286 0.0136986301369863
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.000540725932950577 323 56 7 0.125 0.021671826625387
GO:BP GO:0060828 regulation of canonical Wnt signaling pathway 0.000576893988074232 298 14 4 0.285714285714286 0.0134228187919463
GO:BP GO:0019985 translesion synthesis 0.000655685472961002 42 35 3 0.0857142857142857 0.0714285714285714
GO:BP GO:0070646 protein modification by small protein removal 0.000666072898407588 310 14 4 0.285714285714286 0.0129032258064516
GO:BP GO:0070661 leukocyte proliferation 0.000693365918912174 325 58 7 0.120689655172414 0.0215384615384615
GO:BP GO:0043687 post-translational protein modification 0.000695650544513576 362 23 5 0.217391304347826 0.0138121546961326
GO:BP GO:0010647 positive regulation of cell communication 0.00074740848044106 1777 63 17 0.26984126984127 0.00956668542487338
GO:BP GO:0023056 positive regulation of signaling 0.000770402142832836 1782 63 17 0.26984126984127 0.00953984287317621
GO:BP GO:0045930 negative regulation of mitotic cell cycle 0.000858456584670666 333 14 4 0.285714285714286 0.012012012012012
GO:BP GO:0048729 tissue morphogenesis 0.000881883198486967 667 14 5 0.357142857142857 0.00749625187406297
GO:BP GO:0002757 immune response-activating signal transduction 0.000881883198486967 477 56 8 0.142857142857143 0.0167714884696017
GO:BP GO:0042269 regulation of natural killer cell mediated cytotoxicity 0.000881883198486967 41 40 3 0.075 0.0731707317073171
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.000881883198486967 477 56 8 0.142857142857143 0.0167714884696017
GO:BP GO:0006520 cellular amino acid metabolic process 0.000915347675036893 341 14 4 0.285714285714286 0.0117302052785924
GO:BP GO:0010648 negative regulation of cell communication 0.000923557470829056 1468 31 10 0.32258064516129 0.00681198910081744
GO:BP GO:0023057 negative regulation of signaling 0.000935270026335733 1471 31 10 0.32258064516129 0.00679809653297077
GO:BP GO:0045595 regulation of cell differentiation 0.000936267171404041 1679 14 7 0.5 0.00416914830256105
GO:BP GO:0060070 canonical Wnt signaling pathway 0.000936267171404041 345 14 4 0.285714285714286 0.0115942028985507
GO:BP GO:1901222 regulation of NIK/NF-kappaB signaling 0.000936267171404041 113 40 4 0.1 0.0353982300884956
GO:BP GO:0051701 biological process involved in interaction with host 0.00100089860497333 221 40 5 0.125 0.0226244343891403
GO:BP GO:0051336 regulation of hydrolase activity 0.00101334180463961 1321 41 11 0.268292682926829 0.00832702498107494
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.00103506331453683 155 57 5 0.087719298245614 0.032258064516129
GO:BP GO:1903311 regulation of mRNA metabolic process 0.00103506331453683 356 14 4 0.285714285714286 0.0112359550561798
GO:BP GO:0002715 regulation of natural killer cell mediated immunity 0.00108777832389132 45 40 3 0.075 0.0666666666666667
GO:BP GO:0006301 postreplication repair 0.0011167980789583 52 35 3 0.0857142857142857 0.0576923076923077
GO:BP GO:0001666 response to hypoxia 0.00114764797884685 367 14 4 0.285714285714286 0.0108991825613079
GO:BP GO:0051246 regulation of protein metabolic process 0.00116293810862506 2704 41 16 0.390243902439024 0.00591715976331361
GO:BP GO:0010948 negative regulation of cell cycle process 0.00119875785046119 372 14 4 0.285714285714286 0.010752688172043
GO:BP GO:0000731 DNA synthesis involved in DNA repair 0.0012289411337976 54 35 3 0.0857142857142857 0.0555555555555556
GO:BP GO:0009966 regulation of signal transduction 0.00123339396072938 3165 43 18 0.418604651162791 0.00568720379146919
GO:BP GO:0030111 regulation of Wnt signaling pathway 0.00123339396072938 376 14 4 0.285714285714286 0.0106382978723404
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.0012885441534523 512 56 8 0.142857142857143 0.015625
GO:BP GO:0036293 response to decreased oxygen levels 0.0012885441534523 382 14 4 0.285714285714286 0.0104712041884817
GO:BP GO:0006402 mRNA catabolic process 0.00129921466905023 384 14 4 0.285714285714286 0.0104166666666667
GO:BP GO:0002764 immune response-regulating signaling pathway 0.00133012835412735 515 56 8 0.142857142857143 0.0155339805825243
GO:BP GO:0070482 response to oxygen levels 0.00162634869816499 408 14 4 0.285714285714286 0.00980392156862745
GO:BP GO:0006401 RNA catabolic process 0.00187680860951156 424 14 4 0.285714285714286 0.00943396226415094
GO:BP GO:0046718 viral entry into host cell 0.00195812708735852 141 40 4 0.1 0.0283687943262411
GO:BP GO:0034655 nucleobase-containing compound catabolic process 0.00219299568064034 567 55 8 0.145454545454545 0.0141093474426808
GO:BP GO:0062012 regulation of small molecule metabolic process 0.00225097827109009 447 14 4 0.285714285714286 0.00894854586129754
GO:BP GO:0007259 receptor signaling pathway via JAK-STAT 0.0022696336787574 174 34 4 0.117647058823529 0.0229885057471264
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 0.00230145880611288 451 14 4 0.285714285714286 0.00886917960088692
GO:BP GO:0042267 natural killer cell mediated cytotoxicity 0.00250014681383123 62 40 3 0.075 0.0483870967741935
GO:BP GO:0044409 entry into host 0.0026041262506777 154 40 4 0.1 0.025974025974026
GO:BP GO:0008285 negative regulation of cell population proliferation 0.0026449192338212 790 63 10 0.158730158730159 0.0126582278481013
GO:BP GO:0097696 receptor signaling pathway via STAT 0.00266950313814987 184 34 4 0.117647058823529 0.0217391304347826
GO:BP GO:0001961 positive regulation of cytokine-mediated signaling pathway 0.00266950313814987 50 51 3 0.0588235294117647 0.06
GO:BP GO:0033554 cellular response to stress 0.00272037533719502 2111 35 12 0.342857142857143 0.00568450971103742
GO:BP GO:0002228 natural killer cell mediated immunity 0.0027888458336574 65 40 3 0.075 0.0461538461538462
GO:BP GO:0002456 T cell mediated immunity 0.00279801851962566 98 64 4 0.0625 0.0408163265306122
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.00283642549019088 1082 56 11 0.196428571428571 0.0101663585951941
GO:BP GO:0010468 regulation of gene expression 0.0029555725100864 5196 40 22 0.55 0.00423402617397998
GO:BP GO:0046700 heterocycle catabolic process 0.00299467692486132 602 55 8 0.145454545454545 0.0132890365448505
GO:BP GO:1901987 regulation of cell cycle phase transition 0.00299467692486132 493 14 4 0.285714285714286 0.00811359026369168
GO:BP GO:0044270 cellular nitrogen compound catabolic process 0.0031350325694145 608 55 8 0.145454545454545 0.0131578947368421
GO:BP GO:0098586 cellular response to virus 0.0035310771754541 72 40 3 0.075 0.0416666666666667
GO:BP GO:0019439 aromatic compound catabolic process 0.00359356112705159 623 55 8 0.145454545454545 0.0128410914927769
GO:BP GO:0060760 positive regulation of response to cytokine stimulus 0.00362044763749325 57 51 3 0.0588235294117647 0.0526315789473684
GO:BP GO:0016055 Wnt signaling pathway 0.00372096611972586 529 14 4 0.285714285714286 0.00756143667296786
GO:BP GO:0001910 regulation of leukocyte mediated cytotoxicity 0.00376078351481589 74 40 3 0.075 0.0405405405405405
GO:BP GO:0198738 cell-cell signaling by wnt 0.00376078351481589 531 14 4 0.285714285714286 0.00753295668549906
GO:BP GO:0052126 movement in host environment 0.00393981061089224 177 40 4 0.1 0.0225988700564972
GO:BP GO:0035556 intracellular signal transduction 0.00417513826125771 2772 29 12 0.413793103448276 0.00432900432900433
GO:BP GO:0010646 regulation of cell communication 0.00420780961542907 3543 43 18 0.418604651162791 0.00508044030482642
GO:BP GO:0045321 leukocyte activation 0.0042330717010799 1332 64 13 0.203125 0.00975975975975976
GO:BP GO:0001960 negative regulation of cytokine-mediated signaling pathway 0.00427416491627194 82 38 3 0.0789473684210526 0.0365853658536585
GO:BP GO:0032609 interferon-gamma production 0.00433269251091678 115 63 4 0.0634920634920635 0.0347826086956522
GO:BP GO:0051248 negative regulation of protein metabolic process 0.00433269251091678 1151 56 11 0.196428571428571 0.00955690703735882
GO:BP GO:1903706 regulation of hemopoiesis 0.00450263819628145 424 64 7 0.109375 0.0165094339622642
GO:BP GO:1901361 organic cyclic compound catabolic process 0.00454222885748154 651 55 8 0.145454545454545 0.0122887864823349
GO:BP GO:1901575 organic substance catabolic process 0.00454297520368362 2267 14 7 0.5 0.00308778120864579
GO:BP GO:0032722 positive regulation of chemokine production 0.00458548605180392 63 51 3 0.0588235294117647 0.0476190476190476
GO:BP GO:0023051 regulation of signaling 0.00458548605180392 3578 43 18 0.418604651162791 0.00503074343208496
GO:BP GO:0010950 positive regulation of endopeptidase activity 0.00462019989489999 187 40 4 0.1 0.0213903743315508
GO:BP GO:0050670 regulation of lymphocyte proliferation 0.00473540015027175 230 57 5 0.087719298245614 0.0217391304347826
GO:BP GO:0002703 regulation of leukocyte mediated immunity 0.00478815105902973 205 64 5 0.078125 0.024390243902439
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.00487862246984715 1042 14 5 0.357142857142857 0.00479846449136276
GO:BP GO:0032944 regulation of mononuclear cell proliferation 0.00487862246984715 232 57 5 0.087719298245614 0.021551724137931
GO:BP GO:0048872 homeostasis of number of cells 0.00491513893842342 261 51 5 0.0980392156862745 0.0191570881226054
GO:BP GO:0060761 negative regulation of response to cytokine stimulus 0.00495142146080783 88 38 3 0.0789473684210526 0.0340909090909091
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 0.00519366445329772 4199 35 17 0.485714285714286 0.00404858299595142
GO:BP GO:0044248 cellular catabolic process 0.00529210132720434 2347 14 7 0.5 0.00298253089049851
GO:BP GO:0009887 animal organ morphogenesis 0.00536974092526253 1073 14 5 0.357142857142857 0.00465983224603914
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.00542398138332622 2541 41 14 0.341463414634146 0.00550964187327824
GO:BP GO:0050868 negative regulation of T cell activation 0.00543634369700552 123 64 4 0.0625 0.032520325203252
GO:BP GO:0001819 positive regulation of cytokine production 0.00549827820064288 452 63 7 0.111111111111111 0.0154867256637168
GO:BP GO:0044772 mitotic cell cycle phase transition 0.00556635809565402 609 14 4 0.285714285714286 0.00656814449917898
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 0.00577138948787673 141 57 4 0.0701754385964912 0.0283687943262411
GO:BP GO:0007346 regulation of mitotic cell cycle 0.00586194352182358 619 14 4 0.285714285714286 0.00646203554119548
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 0.0058892972979588 142 57 4 0.0701754385964912 0.028169014084507
GO:BP GO:0010952 positive regulation of peptidase activity 0.00597958421407645 205 40 4 0.1 0.0195121951219512
GO:BP GO:0018130 heterocycle biosynthetic process 0.00606406024750808 4269 35 17 0.485714285714286 0.00398219723588662
GO:BP GO:0019438 aromatic compound biosynthetic process 0.00618238175703928 4278 35 17 0.485714285714286 0.00397381954184198
GO:BP GO:0031341 regulation of cell killing 0.00629936528521578 93 40 3 0.075 0.032258064516129
GO:BP GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 0.00633232520997315 636 14 4 0.285714285714286 0.00628930817610063
GO:BP GO:0002449 lymphocyte mediated immunity 0.00642936379847549 354 41 5 0.121951219512195 0.0141242937853107
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.00648523267997529 547 40 6 0.15 0.0109689213893967
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.00654488243230575 6603 41 25 0.609756097560976 0.0037861578070574
GO:BP GO:0050863 regulation of T cell activation 0.00654488243230575 337 64 6 0.09375 0.0178041543026706
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 0.00658801389193024 338 64 6 0.09375 0.0177514792899408
GO:BP GO:0045786 negative regulation of cell cycle 0.00658801389193024 647 14 4 0.285714285714286 0.00618238021638331
GO:BP GO:0044770 cell cycle phase transition 0.00690172254665204 658 14 4 0.285714285714286 0.0060790273556231
GO:BP GO:0006974 cellular response to DNA damage stimulus 0.00705742303355331 888 35 7 0.2 0.00788288288288288
GO:BP GO:0046649 lymphocyte activation 0.00774220864286664 771 64 9 0.140625 0.0116731517509728
GO:BP GO:0002440 production of molecular mediator of immune response 0.00775802406837176 189 22 3 0.136363636363636 0.0158730158730159
GO:BP GO:0050729 positive regulation of inflammatory response 0.00775802406837176 142 29 3 0.103448275862069 0.0211267605633803
GO:BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 0.00823964560455178 142 64 4 0.0625 0.028169014084507
GO:BP GO:0042110 T cell activation 0.00846760986146087 489 64 7 0.109375 0.0143149284253579
GO:BP GO:0001909 leukocyte mediated cytotoxicity 0.008641607428917 107 40 3 0.075 0.0280373831775701
GO:BP GO:0050793 regulation of developmental process 0.00866048775753215 2605 14 7 0.5 0.00268714011516315
GO:BP GO:1901362 organic cyclic compound biosynthetic process 0.00866218458077674 4439 35 17 0.485714285714286 0.00382969137193061
GO:BP GO:0030218 erythrocyte differentiation 0.00908604070195788 116 38 3 0.0789473684210526 0.0258620689655172
GO:BP GO:0009628 response to abiotic stimulus 0.00943192097787224 1261 14 5 0.357142857142857 0.00396510705789056
GO:BP GO:0001775 cell activation 0.00944661231721653 1495 64 13 0.203125 0.00869565217391304
GO:BP GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 0.00952136123448134 71 63 3 0.0476190476190476 0.0422535211267606
GO:BP GO:0002706 regulation of lymphocyte mediated immunity 0.00978277984588418 151 64 4 0.0625 0.0264900662251656
GO:BP GO:0010467 gene expression 0.00984266739683364 6179 40 23 0.575 0.00372228515941091
GO:BP GO:0045580 regulation of T cell differentiation 0.00991323092479222 152 64 4 0.0625 0.0263157894736842
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.00991323092479222 2719 64 19 0.296875 0.00698786318499448
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.00991323092479222 375 64 6 0.09375 0.016
GO:BP GO:0002200 somatic diversification of immune receptors 0.0100554299224681 72 64 3 0.046875 0.0416666666666667
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.0102896660287262 2518 64 18 0.28125 0.00714853057982526
GO:BP GO:0034101 erythrocyte homeostasis 0.0103148665147171 124 38 3 0.0789473684210526 0.0241935483870968
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 0.0103150611875062 251 40 4 0.1 0.0159362549800797
GO:BP GO:0051250 negative regulation of lymphocyte activation 0.0103953891405841 156 64 4 0.0625 0.0256410256410256
GO:BP GO:0002709 regulation of T cell mediated immunity 0.0104432096035021 74 64 3 0.046875 0.0405405405405405
GO:BP GO:0051249 regulation of lymphocyte activation 0.0104432096035021 518 64 7 0.109375 0.0135135135135135
GO:BP GO:0046651 lymphocyte proliferation 0.0104432096035021 294 57 5 0.087719298245614 0.0170068027210884
GO:BP GO:0009056 catabolic process 0.0105247248095489 2744 14 7 0.5 0.00255102040816327
GO:BP GO:0010608 posttranscriptional regulation of gene expression 0.0105247248095489 896 38 7 0.184210526315789 0.0078125
GO:BP GO:0032642 regulation of chemokine production 0.0106078610784772 94 51 3 0.0588235294117647 0.0319148936170213
GO:BP GO:0002292 T cell differentiation involved in immune response 0.0106301810145584 75 64 3 0.046875 0.04
GO:BP GO:0060429 epithelium development 0.010643579795592 1325 14 5 0.357142857142857 0.00377358490566038
GO:BP GO:0032943 mononuclear cell proliferation 0.0106663862784359 297 57 5 0.087719298245614 0.0168350168350168
GO:BP GO:0042127 regulation of cell population proliferation 0.0116431718876469 1774 63 14 0.222222222222222 0.00789177001127396
GO:BP GO:0000165 MAPK cascade 0.0118700752648743 935 58 9 0.155172413793103 0.00962566844919786
GO:BP GO:0010564 regulation of cell cycle process 0.0119830898113589 809 14 4 0.285714285714286 0.00494437577255871
GO:BP GO:0002250 adaptive immune response 0.012220424887205 689 64 8 0.125 0.011611030478955
GO:BP GO:0032602 chemokine production 0.0123599749419006 101 51 3 0.0588235294117647 0.0297029702970297
GO:BP GO:0044092 negative regulation of molecular function 0.0123740444259355 1219 54 10 0.185185185185185 0.00820344544708778
GO:BP GO:0051252 regulation of RNA metabolic process 0.0128427304938215 3822 35 15 0.428571428571429 0.00392464678178964
GO:BP GO:0050790 regulation of catalytic activity 0.0128971875006295 2545 41 13 0.317073170731707 0.00510805500982318
GO:BP GO:0070664 negative regulation of leukocyte proliferation 0.0133603162101797 92 58 3 0.0517241379310345 0.0326086956521739
GO:BP GO:0002274 myeloid leukocyte activation 0.013394514534577 667 40 6 0.15 0.00899550224887556
GO:BP GO:0009888 tissue development 0.013394514534577 2107 14 6 0.428571428571429 0.00284765068818225
GO:BP GO:0002443 leukocyte mediated immunity 0.0134040137280229 877 41 7 0.170731707317073 0.00798175598631699
GO:BP GO:0065009 regulation of molecular function 0.0134674921688367 3221 41 15 0.365853658536585 0.00465693883886992
GO:BP GO:0002718 regulation of cytokine production involved in immune response 0.0137621689277808 85 64 3 0.046875 0.0352941176470588
GO:BP GO:1902105 regulation of leukocyte differentiation 0.0137635286857553 288 64 5 0.078125 0.0173611111111111
GO:BP GO:0043086 negative regulation of catalytic activity 0.0137635286857553 851 54 8 0.148148148148148 0.00940070505287897
GO:BP GO:0042509 regulation of tyrosine phosphorylation of STAT protein 0.0137635286857553 87 63 3 0.0476190476190476 0.0344827586206897
GO:BP GO:0031329 regulation of cellular catabolic process 0.0137635286857553 866 14 4 0.285714285714286 0.0046189376443418
GO:BP GO:0019222 regulation of metabolic process 0.0137635286857553 7148 14 11 0.785714285714286 0.00153889199776161
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0139510577953164 717 64 8 0.125 0.0111576011157601
GO:BP GO:0016071 mRNA metabolic process 0.0139698690337045 874 14 4 0.285714285714286 0.0045766590389016
GO:BP GO:0007260 tyrosine phosphorylation of STAT protein 0.0140478145448706 89 63 3 0.0476190476190476 0.0337078651685393
GO:BP GO:0002263 cell activation involved in immune response 0.0142646491839392 721 64 8 0.125 0.0110957004160888
GO:BP GO:0045619 regulation of lymphocyte differentiation 0.0143190081943993 180 64 4 0.0625 0.0222222222222222
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 0.0143512428261377 291 40 4 0.1 0.013745704467354
GO:BP GO:0090304 nucleic acid metabolic process 0.0143951204698657 5226 40 20 0.5 0.00382701875239189
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0144949630301515 1160 11 4 0.363636363636364 0.00344827586206897
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0149830783254453 551 22 4 0.181818181818182 0.00725952813067151
GO:BP GO:1903131 mononuclear cell differentiation 0.0151418554847469 430 64 6 0.09375 0.013953488372093
GO:BP GO:0006355 regulation of transcription, DNA-templated 0.0153666681838065 3534 35 14 0.4 0.00396151669496321
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 0.0153777158110932 3535 35 14 0.4 0.00396039603960396
GO:BP GO:2001141 regulation of RNA biosynthetic process 0.0155325462616057 3540 35 14 0.4 0.00395480225988701
GO:BP GO:1903047 mitotic cell cycle process 0.0156823091000756 911 14 4 0.285714285714286 0.00439077936333699
GO:BP GO:0051817 modulation of process of other organism involved in symbiotic interaction 0.015770697926737 102 58 3 0.0517241379310345 0.0294117647058824
GO:BP GO:0002695 negative regulation of leukocyte activation 0.0160046230360375 188 64 4 0.0625 0.0212765957446809
GO:BP GO:0002367 cytokine production involved in immune response 0.0162362907300594 94 64 3 0.046875 0.0319148936170213
GO:BP GO:0006281 DNA repair 0.0166652776941838 576 35 5 0.142857142857143 0.00868055555555556
GO:BP GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0168026392611219 96 64 3 0.046875 0.03125
GO:BP GO:0022407 regulation of cell-cell adhesion 0.0168463410883627 445 64 6 0.09375 0.0134831460674157
GO:BP GO:0022408 negative regulation of cell-cell adhesion 0.0171553005940257 194 64 4 0.0625 0.0206185567010309
GO:BP GO:0002377 immunoglobulin production 0.0178771165141326 99 64 3 0.046875 0.0303030303030303
GO:BP GO:0009617 response to bacterium 0.0185652325849313 743 40 6 0.15 0.00807537012113055
GO:BP GO:0002821 positive regulation of adaptive immune response 0.0186250699784443 101 64 3 0.046875 0.0297029702970297
GO:BP GO:0002694 regulation of leukocyte activation 0.0189758560536886 610 64 7 0.109375 0.0114754098360656
GO:BP GO:0046634 regulation of alpha-beta T cell activation 0.0190731365357954 102 64 3 0.046875 0.0294117647058824
GO:BP GO:0002708 positive regulation of lymphocyte mediated immunity 0.0198297179565375 104 64 3 0.046875 0.0288461538461538
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 0.0198752613452317 4091 35 15 0.428571428571429 0.00366658518699584
GO:BP GO:0044267 cellular protein metabolic process 0.0206139289635317 5229 14 9 0.642857142857143 0.00172117039586919
GO:BP GO:0019752 carboxylic acid metabolic process 0.0210116614001106 1024 14 4 0.285714285714286 0.00390625
GO:BP GO:0097659 nucleic acid-templated transcription 0.0213367886733899 3715 35 14 0.4 0.00376850605652759
GO:BP GO:0006351 transcription, DNA-templated 0.0213367886733899 3714 35 14 0.4 0.00376952073236403
GO:BP GO:0050866 negative regulation of cell activation 0.0213367886733899 211 64 4 0.0625 0.018957345971564
GO:BP GO:0009894 regulation of catabolic process 0.0213510811531382 1033 14 4 0.285714285714286 0.00387221684414327
GO:BP GO:0032649 regulation of interferon-gamma production 0.0213510811531382 110 63 3 0.0476190476190476 0.0272727272727273
GO:BP GO:0043312 neutrophil degranulation 0.0215082511860137 482 15 3 0.2 0.00622406639004149
GO:BP GO:0045892 negative regulation of transcription, DNA-templated 0.0215082511860137 1337 64 11 0.171875 0.00822737471952132
GO:BP GO:0001906 cell killing 0.0215082511860137 175 40 3 0.075 0.0171428571428571
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 0.0215906788499763 1339 64 11 0.171875 0.0082150858849888
GO:BP GO:0032774 RNA biosynthetic process 0.0215906788499763 3731 35 14 0.4 0.00375234521575985
GO:BP GO:0048518 positive regulation of biological process 0.0215906788499763 6363 58 30 0.517241379310345 0.00471475719000472
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 0.0215906788499763 5017 35 17 0.485714285714286 0.00338847917081921
GO:BP GO:0002283 neutrophil activation involved in immune response 0.0215906788499763 485 15 3 0.2 0.00618556701030928
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 0.0216045003531537 1341 64 11 0.171875 0.00820283370618941
GO:BP GO:0002699 positive regulation of immune effector process 0.0219092700294753 215 64 4 0.0625 0.0186046511627907
GO:BP GO:0016070 RNA metabolic process 0.0221553072234384 4710 40 18 0.45 0.00382165605095541
GO:BP GO:0043436 oxoacid metabolic process 0.0222383628478206 1057 14 4 0.285714285714286 0.00378429517502365
GO:BP GO:0000278 mitotic cell cycle 0.0223505940896346 1059 14 4 0.285714285714286 0.00377714825306893
GO:BP GO:0002286 T cell activation involved in immune response 0.0224094961043129 112 64 3 0.046875 0.0267857142857143
GO:BP GO:0002446 neutrophil mediated immunity 0.0224120637549952 497 15 3 0.2 0.00603621730382294
GO:BP GO:0042119 neutrophil activation 0.0224995377314309 498 15 3 0.2 0.00602409638554217
GO:BP GO:0034645 cellular macromolecule biosynthetic process 0.0224995377314309 5051 35 17 0.485714285714286 0.0033656701643239
GO:BP GO:0051239 regulation of multicellular organismal process 0.0230876696877329 2861 54 16 0.296296296296296 0.00559245019224047
GO:BP GO:0036230 granulocyte activation 0.0231056319621849 504 15 3 0.2 0.00595238095238095
GO:BP GO:0031396 regulation of protein ubiquitination 0.0234768545419222 211 35 3 0.0857142857142857 0.014218009478673
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 0.0236927326041874 185 40 3 0.075 0.0162162162162162
GO:BP GO:0006082 organic acid metabolic process 0.0240334975840419 1090 14 4 0.285714285714286 0.0036697247706422
GO:BP GO:0050865 regulation of cell activation 0.0243462672126411 655 64 7 0.109375 0.0106870229007634
GO:BP GO:0009059 macromolecule biosynthetic process 0.0247871255748183 5114 35 17 0.485714285714286 0.003324208056316
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 0.0249236726833085 2555 14 6 0.428571428571429 0.00234833659491194
GO:BP GO:0031400 negative regulation of protein modification process 0.0252001220363344 578 56 6 0.107142857142857 0.0103806228373702
GO:BP GO:0006366 transcription by RNA polymerase II 0.0254547977731797 2723 34 11 0.323529411764706 0.00403966213734851
GO:BP GO:0043299 leukocyte degranulation 0.0257287917185435 535 15 3 0.2 0.00560747663551402
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0257287917185435 363 41 4 0.0975609756097561 0.0110192837465565
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.0259533622228217 5848 41 21 0.51219512195122 0.00359097127222982
GO:BP GO:0002705 positive regulation of leukocyte mediated immunity 0.02615164575562 122 64 3 0.046875 0.0245901639344262
GO:BP GO:0097193 intrinsic apoptotic signaling pathway 0.0262207090619983 294 27 3 0.111111111111111 0.0102040816326531
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.0263078085995458 365 64 5 0.078125 0.0136986301369863
GO:BP GO:0045862 positive regulation of proteolysis 0.0264971335764647 378 40 4 0.1 0.0105820105820106
GO:BP GO:0008283 cell population proliferation 0.0271507089210747 2054 63 14 0.222222222222222 0.0068159688412853
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.028705442470261 1037 43 7 0.162790697674419 0.00675024108003857
GO:BP GO:2000113 negative regulation of cellular macromolecule biosynthetic process 0.0293680450691283 1628 64 12 0.1875 0.00737100737100737
GO:BP GO:0018108 peptidyl-tyrosine phosphorylation 0.0294226413900511 385 63 5 0.0793650793650794 0.012987012987013
GO:BP GO:0018212 peptidyl-tyrosine modification 0.0298590951532607 388 63 5 0.0793650793650794 0.0128865979381443
GO:BP GO:0055085 transmembrane transport 0.0298590951532607 1635 16 5 0.3125 0.00305810397553517
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 0.0300834752383271 1639 35 8 0.228571428571429 0.0048810250152532
GO:BP GO:1903320 regulation of protein modification by small protein conjugation or removal 0.0301605683536533 243 35 3 0.0857142857142857 0.0123456790123457
GO:BP GO:0019538 protein metabolic process 0.0307273687277156 5808 42 21 0.5 0.00361570247933884
GO:BP GO:0050789 regulation of biological process 0.0307273687277156 12091 11 11 1 0.000909767595732363
GO:BP GO:0055086 nucleobase-containing small molecule metabolic process 0.0307743936765543 629 55 6 0.109090909090909 0.0095389507154213
GO:BP GO:0051253 negative regulation of RNA metabolic process 0.0307778327631224 1445 64 11 0.171875 0.00761245674740484
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.0310073660360612 5746 35 18 0.514285714285714 0.0031326139923425
GO:BP GO:0030099 myeloid cell differentiation 0.0312448935612562 428 38 4 0.105263157894737 0.00934579439252336
GO:BP GO:0051726 regulation of cell cycle 0.0321664637168759 1236 14 4 0.285714285714286 0.00323624595469256
GO:BP GO:0048513 animal organ development 0.0322605453431255 3672 14 7 0.5 0.00190631808278867
GO:BP GO:0042129 regulation of T cell proliferation 0.0326763684094304 176 50 3 0.06 0.0170454545454545
GO:BP GO:0002521 leukocyte differentiation 0.0332899591026847 550 64 6 0.09375 0.0109090909090909
GO:BP GO:0030217 T cell differentiation 0.0343029024753602 260 64 4 0.0625 0.0153846153846154
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 0.0346330184338334 901 64 8 0.125 0.00887902330743618
GO:BP GO:0080090 regulation of primary metabolic process 0.0349542566142819 6053 41 21 0.51219512195122 0.00346935403931935
GO:BP GO:0002221 pattern recognition receptor signaling pathway 0.0352956954937715 213 43 3 0.0697674418604651 0.0140845070422535
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.0352956954937715 1477 40 8 0.2 0.00541638456330399
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 0.035716046594979 1707 35 8 0.228571428571429 0.00468658465143527
GO:BP GO:0050730 regulation of peptidyl-tyrosine phosphorylation 0.035716046594979 269 63 4 0.0634920634920635 0.0148698884758364
GO:BP GO:0009451 RNA modification 0.0360841527584799 168 55 3 0.0545454545454545 0.0178571428571429
GO:BP GO:2000112 regulation of cellular macromolecule biosynthetic process 0.0368863689099317 4071 35 14 0.4 0.00343895848685827
GO:BP GO:0002696 positive regulation of leukocyte activation 0.0372609125174709 412 64 5 0.078125 0.0121359223300971
GO:BP GO:0009890 negative regulation of biosynthetic process 0.0387939952970639 1740 35 8 0.228571428571429 0.00459770114942529
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 0.0388178350210657 4102 35 14 0.4 0.00341296928327645
GO:BP GO:0046483 heterocycle metabolic process 0.0388939732637653 5904 35 18 0.514285714285714 0.00304878048780488
GO:BP GO:0043170 macromolecule metabolic process 0.039384710739473 9796 42 30 0.714285714285714 0.00306247447937934
GO:BP GO:0050867 positive regulation of cell activation 0.0402697525410579 424 64 5 0.078125 0.0117924528301887
GO:BP GO:0048522 positive regulation of cellular process 0.0403491501502825 5757 31 16 0.516129032258065 0.00277922529095015
GO:BP GO:0046631 alpha-beta T cell activation 0.0410923902026886 155 64 3 0.046875 0.0193548387096774
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.0411083031953122 5956 35 18 0.514285714285714 0.00302216252518469
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 0.0436147534018594 1548 64 11 0.171875 0.00710594315245478
GO:BP GO:0042098 T cell proliferation 0.0438258698705565 205 50 3 0.06 0.0146341463414634
GO:BP GO:0051247 positive regulation of protein metabolic process 0.0444288240383321 1564 40 8 0.2 0.0051150895140665
GO:BP GO:0006810 transport 0.0451201588482841 5224 16 9 0.5625 0.00172281776416539
GO:BP GO:0006259 DNA metabolic process 0.0452605293919444 965 64 8 0.125 0.00829015544041451
GO:BP GO:0010628 positive regulation of gene expression 0.0457927178128827 1160 64 9 0.140625 0.00775862068965517
GO:BP GO:0050794 regulation of cellular process 0.046866681008967 11473 36 29 0.805555555555556 0.00252767366861327
GO:BP GO:0022402 cell cycle process 0.0470721612236363 1439 14 4 0.285714285714286 0.00277970813064628
GO:BP GO:0031323 regulation of cellular metabolic process 0.0471882654420884 6269 41 21 0.51219512195122 0.0033498165576647
GO:BP GO:0006464 cellular protein modification process 0.0473223491166951 4041 14 7 0.5 0.00173224449393714
GO:BP GO:0036211 protein modification process 0.0473223491166951 4041 14 7 0.5 0.00173224449393714
GO:BP GO:0006887 exocytosis 0.0476488915350207 904 44 6 0.136363636363636 0.00663716814159292
GO:BP GO:1901136 carbohydrate derivative catabolic process 0.048297885426593 196 55 3 0.0545454545454545 0.0153061224489796
GO:BP GO:0065007 biological regulation 0.0486479371737838 12809 11 11 1 0.000858771176516512
GO:BP GO:0031326 regulation of cellular biosynthetic process 0.0493646258108983 4273 35 14 0.4 0.00327638661362041
GO:BP GO:0007162 negative regulation of cell adhesion 0.0493646258108983 304 64 4 0.0625 0.0131578947368421
GO:BP GO:0050727 regulation of inflammatory response 0.0493646258108983 381 29 3 0.103448275862069 0.0078740157480315
GO:CC GO:0000502 proteasome complex 1.36946253309669e-05 66 14 4 0.285714285714286 0.0606060606060606
GO:CC GO:0042612 MHC class I protein complex 1.36946253309669e-05 8 22 3 0.136363636363636 0.375
GO:CC GO:1905369 endopeptidase complex 1.36946253309669e-05 72 14 4 0.285714285714286 0.0555555555555556
GO:CC GO:1905368 peptidase complex 3.28299412368601e-05 96 14 4 0.285714285714286 0.0416666666666667
GO:CC GO:0030670 phagocytic vesicle membrane 6.07989255229916e-05 76 22 4 0.181818181818182 0.0526315789473684
GO:CC GO:0098553 lumenal side of endoplasmic reticulum membrane 7.53215220423229e-05 25 22 3 0.136363636363636 0.12
GO:CC GO:0042611 MHC protein complex 7.53215220423229e-05 24 22 3 0.136363636363636 0.125
GO:CC GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 7.53215220423229e-05 25 22 3 0.136363636363636 0.12
GO:CC GO:0098576 lumenal side of membrane 0.000145312615797155 33 22 3 0.136363636363636 0.0909090909090909
GO:CC GO:0045335 phagocytic vesicle 0.000317671186076052 137 22 4 0.181818181818182 0.0291970802919708
GO:CC GO:0030666 endocytic vesicle membrane 0.000427707127223651 159 22 4 0.181818181818182 0.0251572327044025
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 0.000427707127223651 158 22 4 0.181818181818182 0.0253164556962025
GO:CC GO:0012507 ER to Golgi transport vesicle membrane 0.000467722406567415 57 22 3 0.136363636363636 0.0526315789473684
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 0.000467722406567415 166 22 4 0.181818181818182 0.0240963855421687
GO:CC GO:0055038 recycling endosome membrane 0.00134327095687922 84 22 3 0.136363636363636 0.0357142857142857
GO:CC GO:0030134 COPII-coated ER to Golgi transport vesicle 0.00151109958463941 90 22 3 0.136363636363636 0.0333333333333333
GO:CC GO:0140535 intracellular protein-containing complex 0.00151637207183887 767 14 5 0.357142857142857 0.00651890482398957
GO:CC GO:0098827 endoplasmic reticulum subcompartment 0.00233616403166327 1122 23 7 0.304347826086957 0.00623885918003565
GO:CC GO:0005789 endoplasmic reticulum membrane 0.00233616403166327 1117 23 7 0.304347826086957 0.0062667860340197
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 0.00246398592828459 1139 23 7 0.304347826086957 0.00614574187884109
GO:CC GO:0030139 endocytic vesicle 0.00316607618254013 306 22 4 0.181818181818182 0.0130718954248366
GO:CC GO:0070062 extracellular exosome 0.00329180904685978 2176 22 9 0.409090909090909 0.00413602941176471
GO:CC GO:0043230 extracellular organelle 0.00404899136284009 2263 22 9 0.409090909090909 0.00397702165267344
GO:CC GO:0031982 vesicle 0.00404899136284009 4055 19 11 0.578947368421053 0.00271270036991369
GO:CC GO:1903561 extracellular vesicle 0.00404899136284009 2261 22 9 0.409090909090909 0.00398053958425475
GO:CC GO:0031984 organelle subcompartment 0.00515263484988892 1773 23 8 0.347826086956522 0.00451212633953751
GO:CC GO:0031901 early endosome membrane 0.00515263484988892 159 22 3 0.136363636363636 0.0188679245283019
GO:CC GO:0031301 integral component of organelle membrane 0.0056197355581398 382 22 4 0.181818181818182 0.0104712041884817
GO:CC GO:0030662 coated vesicle membrane 0.00663599950921481 177 22 3 0.136363636363636 0.0169491525423729
GO:CC GO:0032991 protein-containing complex 0.0066878051794325 5548 16 11 0.6875 0.00198269646719539
GO:CC GO:0031300 intrinsic component of organelle membrane 0.0066878051794325 413 22 4 0.181818181818182 0.00968523002421308
GO:CC GO:0031090 organelle membrane 0.00676047550477948 3612 4 4 1 0.00110741971207087
GO:CC GO:0055037 recycling endosome 0.00676047550477948 188 22 3 0.136363636363636 0.0159574468085106
GO:CC GO:0009986 cell surface 0.0067781513177336 899 57 9 0.157894736842105 0.0100111234705228
GO:CC GO:0098588 bounding membrane of organelle 0.00723242307896365 2158 3 3 1 0.00139017608897127
GO:CC GO:0030667 secretory granule membrane 0.00749745581803504 303 15 3 0.2 0.0099009900990099
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.00782134732491603 779 22 5 0.227272727272727 0.00641848523748395
GO:CC GO:0030658 transport vesicle membrane 0.00785663885228753 209 22 3 0.136363636363636 0.0143540669856459
GO:CC GO:0012506 vesicle membrane 0.00844356720507149 800 22 5 0.227272727272727 0.00625
GO:CC GO:0010008 endosome membrane 0.0105481343227506 505 22 4 0.181818181818182 0.00792079207920792
GO:CC GO:1902494 catalytic complex 0.0111214082293603 1441 14 5 0.357142857142857 0.00346981263011797
GO:CC GO:0005654 nucleoplasm 0.0111214082293603 4102 34 15 0.441176470588235 0.00365675280351048
GO:CC GO:0005829 cytosol 0.0111214082293603 5303 35 18 0.514285714285714 0.00339430511031492
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0112907381287524 11296 35 29 0.828571428571429 0.00256728045325779
GO:CC GO:0031981 nuclear lumen 0.0117535345851343 4444 38 17 0.447368421052632 0.00382538253825383
GO:CC GO:0005576 extracellular region 0.0119134615515428 4567 15 9 0.6 0.00197065907597986
GO:CC GO:0030135 coated vesicle 0.0161782842519958 295 22 3 0.136363636363636 0.0101694915254237
GO:CC GO:0005768 endosome 0.0163905784687659 987 22 5 0.227272727272727 0.00506585612968592
GO:CC GO:0005634 nucleus 0.0170186696009216 7592 35 22 0.628571428571429 0.00289778714436249
GO:CC GO:0031965 nuclear membrane 0.0170254851843539 298 23 3 0.130434782608696 0.0100671140939597
GO:CC GO:0098552 side of membrane 0.0206421146578369 619 52 6 0.115384615384615 0.00969305331179321
GO:CC GO:0005783 endoplasmic reticulum 0.0218659309706076 1982 23 7 0.304347826086957 0.00353178607467205
GO:CC GO:0005737 cytoplasm 0.0218659309706076 11911 20 18 0.9 0.00151120812694148
GO:CC GO:0048471 perinuclear region of cytoplasm 0.0238989336266031 735 33 5 0.151515151515152 0.00680272108843537
GO:CC GO:0016021 integral component of membrane 0.0238989336266031 5711 4 4 1 0.000700402731570653
GO:CC GO:0005615 extracellular space 0.0244604362190068 3594 58 19 0.327586206896552 0.00528658875904285
GO:CC GO:0031224 intrinsic component of membrane 0.0247103445582276 5868 4 4 1 0.000681663258350375
GO:CC GO:0005769 early endosome 0.0247103445582276 378 22 3 0.136363636363636 0.00793650793650794
GO:CC GO:0070013 intracellular organelle lumen 0.0247133757492328 5402 35 17 0.485714285714286 0.00314698259903739
GO:CC GO:0030133 transport vesicle 0.0280917805091255 414 22 3 0.136363636363636 0.0072463768115942
GO:CC GO:0043233 organelle lumen 0.0288950786891586 5565 35 17 0.485714285714286 0.00305480682839173
GO:CC GO:0031974 membrane-enclosed lumen 0.0288950786891586 5565 35 17 0.485714285714286 0.00305480682839173
GO:CC GO:0012505 endomembrane system 0.0328459489285223 4640 3 3 1 0.000646551724137931
GO:CC GO:0097708 intracellular vesicle 0.0363657768864742 2428 22 7 0.318181818181818 0.0028830313014827
GO:CC GO:0031410 cytoplasmic vesicle 0.0363657768864742 2424 22 7 0.318181818181818 0.00288778877887789
GO:CC GO:0098791 Golgi apparatus subcompartment 0.0381613323980441 885 22 4 0.181818181818182 0.00451977401129944
GO:CC GO:0005635 nuclear envelope 0.0391255384000761 467 23 3 0.130434782608696 0.00642398286937901
GO:CC GO:0043229 intracellular organelle 0.0463170158025223 12491 35 29 0.828571428571429 0.00232167160355456
GO:MF GO:0046977 TAP binding 5.98309002891092e-06 9 16 3 0.1875 0.333333333333333
GO:MF GO:0042605 peptide antigen binding 5.98309002891092e-06 30 22 4 0.181818181818182 0.133333333333333
GO:MF GO:1990404 protein ADP-ribosylase activity 0.000306595915295052 16 35 3 0.0857142857142857 0.1875
GO:MF GO:0003950 NAD+ ADP-ribosyltransferase activity 0.00118420320918898 27 35 3 0.0857142857142857 0.111111111111111
GO:MF GO:0003823 antigen binding 0.00160308429299396 163 22 4 0.181818181818182 0.0245398773006135
GO:MF GO:0016763 transferase activity, transferring pentosyl groups 0.00360413765471919 56 35 3 0.0857142857142857 0.0535714285714286
GO:MF GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.00360413765471919 35 55 3 0.0545454545454545 0.0857142857142857
GO:MF GO:0019239 deaminase activity 0.00360413765471919 32 55 3 0.0545454545454545 0.09375
GO:MF GO:0042802 identical protein binding 0.00360413765471919 2067 29 11 0.379310344827586 0.00532172230285438
GO:MF GO:0061135 endopeptidase regulator activity 0.00582966975604064 188 14 3 0.214285714285714 0.0159574468085106
GO:MF GO:0042277 peptide binding 0.00694640929136149 314 22 4 0.181818181818182 0.0127388535031847
GO:MF GO:0003725 double-stranded RNA binding 0.00741329096803844 77 38 3 0.0789473684210526 0.038961038961039
GO:MF GO:0061134 peptidase regulator activity 0.00741329096803844 224 14 3 0.214285714285714 0.0133928571428571
GO:MF GO:0044389 ubiquitin-like protein ligase binding 0.00884787871136627 314 11 3 0.272727272727273 0.00955414012738853
GO:MF GO:0033218 amide binding 0.0107403194954251 389 22 4 0.181818181818182 0.0102827763496144
GO:MF GO:0005102 signaling receptor binding 0.0243075678140537 1672 63 13 0.206349206349206 0.00777511961722488
GO:MF GO:0003714 transcription corepressor activity 0.0278836815941165 187 35 3 0.0857142857142857 0.0160427807486631
GO:MF GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.0336600616126906 132 55 3 0.0545454545454545 0.0227272727272727
GO:MF GO:0005525 GTP binding 0.0342851513024392 381 21 3 0.142857142857143 0.0078740157480315
GO:MF GO:0005515 protein binding 0.0342851513024392 14767 46 43 0.934782608695652 0.00291189815128327
GO:MF GO:0005125 cytokine activity 0.0342851513024392 235 63 4 0.0634920634920635 0.0170212765957447
GO:MF GO:0032550 purine ribonucleoside binding 0.0347247134720875 386 21 3 0.142857142857143 0.0077720207253886
GO:MF GO:0001883 purine nucleoside binding 0.0347247134720875 389 21 3 0.142857142857143 0.0077120822622108
GO:MF GO:0032549 ribonucleoside binding 0.0347247134720875 389 21 3 0.142857142857143 0.0077120822622108
GO:MF GO:0001882 nucleoside binding 0.0352252849238463 395 21 3 0.142857142857143 0.00759493670886076
GO:MF GO:0032561 guanyl ribonucleotide binding 0.0357503776772275 403 21 3 0.142857142857143 0.00744416873449132
GO:MF GO:0019001 guanyl nucleotide binding 0.0357503776772275 403 21 3 0.142857142857143 0.00744416873449132
GO:MF GO:0098772 molecular function regulator 0.0372488111958924 2363 63 15 0.238095238095238 0.00634786288616166
GO:MF GO:0016757 transferase activity, transferring glycosyl groups 0.0426959614594481 283 60 4 0.0666666666666667 0.0141342756183746
GO:MF GO:0003712 transcription coregulator activity 0.0431118603985642 506 35 4 0.114285714285714 0.00790513833992095
GO:MF GO:0005126 cytokine receptor binding 0.0431118603985642 275 63 4 0.0634920634920635 0.0145454545454545
HP HP:0030354 Abnormal serum interferon level 7.14429813674207e-06 11 38 5 0.131578947368421 0.454545454545455
HP HP:0030355 Abnormal serum interferon-gamma level 7.14429813674207e-06 11 38 5 0.131578947368421 0.454545454545455
HP HP:0011111 Abnormality of immune serum protein physiology 0.000303375208184378 24 38 5 0.131578947368421 0.208333333333333
HP HP:0011112 Abnormality of serum cytokine level 0.000303375208184378 23 38 5 0.131578947368421 0.217391304347826
HP HP:0030356 Increased serum interferon-gamma level 0.00491758162013679 8 38 3 0.0789473684210526 0.375
HP HP:0012490 Panniculitis 0.00491758162013679 22 38 4 0.105263157894737 0.181818181818182
HP HP:0100614 Myositis 0.0160506446421107 32 38 4 0.105263157894737 0.125
KEGG KEGG:04612 Antigen processing and presentation 1.61092640547008e-06 69 22 6 0.272727272727273 0.0869565217391304
KEGG KEGG:03050 Proteasome 2.42548950332482e-05 46 14 4 0.285714285714286 0.0869565217391304
KEGG KEGG:05169 Epstein-Barr virus infection 2.42548950332482e-05 198 33 8 0.242424242424242 0.0404040404040404
KEGG KEGG:05170 Human immunodeficiency virus 1 infection 0.000291617572313009 210 22 6 0.272727272727273 0.0285714285714286
KEGG KEGG:05332 Graft-versus-host disease 0.00120429414975911 37 22 3 0.136363636363636 0.0810810810810811
KEGG KEGG:05330 Allograft rejection 0.00120429414975911 34 22 3 0.136363636363636 0.0882352941176471
KEGG KEGG:05165 Human papillomavirus infection 0.00120429414975911 331 28 7 0.25 0.0211480362537764
KEGG KEGG:05162 Measles 0.00120429414975911 139 46 6 0.130434782608696 0.0431654676258993
KEGG KEGG:04940 Type I diabetes mellitus 0.00135392384042258 40 22 3 0.136363636363636 0.075
KEGG KEGG:05167 Kaposi sarcoma-associated herpesvirus infection 0.00166002820117637 193 52 7 0.134615384615385 0.0362694300518135
KEGG KEGG:05320 Autoimmune thyroid disease 0.00190252028595527 49 22 3 0.136363636363636 0.0612244897959184
KEGG KEGG:05171 Coronavirus disease - COVID-19 0.00190252028595527 231 46 7 0.152173913043478 0.0303030303030303
KEGG KEGG:05164 Influenza A 0.00212175728944423 169 46 6 0.130434782608696 0.0355029585798817
KEGG KEGG:05416 Viral myocarditis 0.00237336759363071 56 22 3 0.136363636363636 0.0535714285714286
KEGG KEGG:04145 Phagosome 0.00300921077730542 147 22 4 0.181818181818182 0.0272108843537415
KEGG KEGG:05168 Herpes simplex virus 1 infection 0.00319739186586221 494 33 8 0.242424242424242 0.0161943319838057
KEGG KEGG:05160 Hepatitis C 0.0083955557042517 157 46 5 0.108695652173913 0.0318471337579618
KEGG KEGG:05163 Human cytomegalovirus infection 0.0117379801432773 223 22 4 0.181818181818182 0.0179372197309417
KEGG KEGG:04650 Natural killer cell mediated cytotoxicity 0.0169456487831725 123 22 3 0.136363636363636 0.024390243902439
KEGG KEGG:05203 Viral carcinogenesis 0.018324447381058 202 28 4 0.142857142857143 0.0198019801980198
KEGG KEGG:04514 Cell adhesion molecules 0.0247098790389029 146 22 3 0.136363636363636 0.0205479452054795
KEGG KEGG:04218 Cellular senescence 0.027738140140972 156 22 3 0.136363636363636 0.0192307692307692
KEGG KEGG:04630 JAK-STAT signaling pathway 0.027738140140972 162 63 5 0.0793650793650794 0.0308641975308642
MIRNA MIRNA:hsa-miR-146a-5p hsa-miR-146a-5p 2.16141932377295e-08 200 26 9 0.346153846153846 0.045
REAC REAC:R-HSA-909733 Interferon alpha/beta signaling 1.74369744869711e-22 66 46 16 0.347826086956522 0.242424242424242
REAC REAC:R-HSA-913531 Interferon Signaling 6.22967236002717e-20 191 38 18 0.473684210526316 0.0942408376963351
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 7.40009230493629e-13 842 51 25 0.490196078431373 0.0296912114014252
REAC REAC:R-HSA-1236974 ER-Phagosome pathway 1.97884220695404e-10 83 22 8 0.363636363636364 0.0963855421686747
REAC REAC:R-HSA-1236975 Antigen processing-Cross presentation 6.74176528840413e-10 99 22 8 0.363636363636364 0.0808080808080808
REAC REAC:R-HSA-168256 Immune System 2.51817877461643e-08 2139 52 31 0.596153846153846 0.0144927536231884
REAC REAC:R-HSA-983169 Class I MHC mediated antigen processing & presentation 7.42345691821866e-07 370 16 8 0.5 0.0216216216216216
REAC REAC:R-HSA-8939902 Regulation of RUNX2 expression and activity 7.42345691821866e-07 71 14 5 0.357142857142857 0.0704225352112676
REAC REAC:R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 3.66802623605849e-06 78 33 6 0.181818181818182 0.0769230769230769
REAC REAC:R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 4.52619825710094e-06 25 22 4 0.181818181818182 0.16
REAC REAC:R-HSA-69541 Stabilization of p53 5.88678183249835e-06 57 14 4 0.285714285714286 0.0701754385964912
REAC REAC:R-HSA-9604323 Negative regulation of NOTCH4 signaling 5.88678183249835e-06 53 14 4 0.285714285714286 0.0754716981132075
REAC REAC:R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 5.88678183249835e-06 60 14 4 0.285714285714286 0.0666666666666667
REAC REAC:R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 5.88678183249835e-06 55 14 4 0.285714285714286 0.0727272727272727
REAC REAC:R-HSA-5610783 Degradation of GLI2 by the proteasome 5.88678183249835e-06 60 14 4 0.285714285714286 0.0666666666666667
REAC REAC:R-HSA-69610 p53-Independent DNA Damage Response 5.88678183249835e-06 52 14 4 0.285714285714286 0.0769230769230769
REAC REAC:R-HSA-5676590 NIK-->noncanonical NF-kB signaling 5.88678183249835e-06 59 14 4 0.285714285714286 0.0677966101694915
REAC REAC:R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 5.88678183249835e-06 52 14 4 0.285714285714286 0.0769230769230769
REAC REAC:R-HSA-351202 Metabolism of polyamines 5.88678183249835e-06 58 14 4 0.285714285714286 0.0689655172413793
REAC REAC:R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 5.88678183249835e-06 52 14 4 0.285714285714286 0.0769230769230769
REAC REAC:R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 5.88678183249835e-06 59 14 4 0.285714285714286 0.0677966101694915
REAC REAC:R-HSA-5610780 Degradation of GLI1 by the proteasome 5.88678183249835e-06 60 14 4 0.285714285714286 0.0666666666666667
REAC REAC:R-HSA-5387390 Hh mutants abrogate ligand secretion 5.88678183249835e-06 59 14 4 0.285714285714286 0.0677966101694915
REAC REAC:R-HSA-169911 Regulation of Apoptosis 5.88678183249835e-06 53 14 4 0.285714285714286 0.0754716981132075
REAC REAC:R-HSA-4641258 Degradation of DVL 5.88678183249835e-06 57 14 4 0.285714285714286 0.0701754385964912
REAC REAC:R-HSA-4641257 Degradation of AXIN 5.88678183249835e-06 55 14 4 0.285714285714286 0.0727272727272727
REAC REAC:R-HSA-8878166 Transcriptional regulation by RUNX2 5.88678183249835e-06 118 14 5 0.357142857142857 0.0423728813559322
REAC REAC:R-HSA-5362768 Hh mutants are degraded by ERAD 5.88678183249835e-06 56 14 4 0.285714285714286 0.0714285714285714
REAC REAC:R-HSA-8941858 Regulation of RUNX3 expression and activity 5.88678183249835e-06 54 14 4 0.285714285714286 0.0740740740740741
REAC REAC:R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 5.88678183249835e-06 50 14 4 0.285714285714286 0.08
REAC REAC:R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 5.88678183249835e-06 51 14 4 0.285714285714286 0.0784313725490196
REAC REAC:R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 5.88678183249835e-06 60 14 4 0.285714285714286 0.0666666666666667
REAC REAC:R-HSA-180585 Vif-mediated degradation of APOBEC3G 5.88678183249835e-06 53 14 4 0.285714285714286 0.0754716981132075
REAC REAC:R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 5.88678183249835e-06 55 14 4 0.285714285714286 0.0727272727272727
REAC REAC:R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 5.88678183249835e-06 50 14 4 0.285714285714286 0.08
REAC REAC:R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 5.88678183249835e-06 52 14 4 0.285714285714286 0.0769230769230769
REAC REAC:R-HSA-180534 Vpu mediated degradation of CD4 5.88678183249835e-06 52 14 4 0.285714285714286 0.0769230769230769
REAC REAC:R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 5.88678183249835e-06 60 14 4 0.285714285714286 0.0666666666666667
REAC REAC:R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 5.88678183249835e-06 52 14 4 0.285714285714286 0.0769230769230769
REAC REAC:R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 5.88678183249835e-06 54 14 4 0.285714285714286 0.0740740740740741
REAC REAC:R-HSA-1169408 ISG15 antiviral mechanism 6.00819272501797e-06 70 28 5 0.178571428571429 0.0714285714285714
REAC REAC:R-HSA-5678895 Defective CFTR causes cystic fibrosis 6.00819272501797e-06 61 14 4 0.285714285714286 0.0655737704918033
REAC REAC:R-HSA-4608870 Asymmetric localization of PCP proteins 6.9518187285073e-06 64 14 4 0.285714285714286 0.0625
REAC REAC:R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 6.9518187285073e-06 64 14 4 0.285714285714286 0.0625
REAC REAC:R-HSA-69563 p53-Dependent G1 DNA Damage Response 7.07016148674992e-06 66 14 4 0.285714285714286 0.0606060606060606
REAC REAC:R-HSA-1236977 Endosomal/Vacuolar pathway 7.07016148674992e-06 11 22 3 0.136363636363636 0.272727272727273
REAC REAC:R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 7.07016148674992e-06 66 14 4 0.285714285714286 0.0606060606060606
REAC REAC:R-HSA-5358346 Hedgehog ligand biogenesis 7.07016148674992e-06 65 14 4 0.285714285714286 0.0615384615384615
REAC REAC:R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 7.07016148674992e-06 66 14 4 0.285714285714286 0.0606060606060606
REAC REAC:R-HSA-5658442 Regulation of RAS by GAPs 7.21869566079643e-06 67 14 4 0.285714285714286 0.0597014925373134
REAC REAC:R-HSA-1169091 Activation of NF-kappaB in B cells 7.21869566079643e-06 67 14 4 0.285714285714286 0.0597014925373134
REAC REAC:R-HSA-68867 Assembly of the pre-replicative complex 7.23824557707934e-06 68 14 4 0.285714285714286 0.0588235294117647
REAC REAC:R-HSA-69615 G1/S DNA Damage Checkpoints 7.23824557707934e-06 68 14 4 0.285714285714286 0.0588235294117647
REAC REAC:R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 7.23824557707934e-06 68 14 4 0.285714285714286 0.0588235294117647
REAC REAC:R-HSA-8948751 Regulation of PTEN stability and activity 7.53822903895031e-06 69 14 4 0.285714285714286 0.0579710144927536
REAC REAC:R-HSA-68949 Orc1 removal from chromatin 8.30845011356774e-06 71 14 4 0.285714285714286 0.0563380281690141
REAC REAC:R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 8.97254646127591e-06 73 14 4 0.285714285714286 0.0547945205479452
REAC REAC:R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 8.97254646127591e-06 73 14 4 0.285714285714286 0.0547945205479452
REAC REAC:R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 9.16210515283242e-06 74 14 4 0.285714285714286 0.0540540540540541
REAC REAC:R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 9.16210515283242e-06 74 14 4 0.285714285714286 0.0540540540540541
REAC REAC:R-HSA-1234174 Cellular response to hypoxia 9.51236966869743e-06 75 14 4 0.285714285714286 0.0533333333333333
REAC REAC:R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 9.87136164357739e-06 76 14 4 0.285714285714286 0.0526315789473684
REAC REAC:R-HSA-5619084 ABC transporter disorders 1.00791922722164e-05 77 14 4 0.285714285714286 0.051948051948052
REAC REAC:R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 1.00791922722164e-05 77 14 4 0.285714285714286 0.051948051948052
REAC REAC:R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.10016844575969e-05 79 14 4 0.285714285714286 0.0506329113924051
REAC REAC:R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 1.1396566801344e-05 80 14 4 0.285714285714286 0.05
REAC REAC:R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 1.16271260718558e-05 81 14 4 0.285714285714286 0.0493827160493827
REAC REAC:R-HSA-9013694 Signaling by NOTCH4 1.16271260718558e-05 81 14 4 0.285714285714286 0.0493827160493827
REAC REAC:R-HSA-168249 Innate Immune System 1.20702882050966e-05 1073 15 9 0.6 0.00838769804287046
REAC REAC:R-HSA-195253 Degradation of beta-catenin by the destruction complex 1.22809283822048e-05 83 14 4 0.285714285714286 0.0481927710843374
REAC REAC:R-HSA-69202 Cyclin E associated events during G1/S transition 1.22809283822048e-05 83 14 4 0.285714285714286 0.0481927710843374
REAC REAC:R-HSA-69002 DNA Replication Pre-Initiation 1.29634015580569e-05 85 14 4 0.285714285714286 0.0470588235294118
REAC REAC:R-HSA-5632684 Hedgehog 'on' state 1.29634015580569e-05 85 14 4 0.285714285714286 0.0470588235294118
REAC REAC:R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 1.29634015580569e-05 85 14 4 0.285714285714286 0.0470588235294118
REAC REAC:R-HSA-157118 Signaling by NOTCH 1.30525755520733e-05 197 14 5 0.357142857142857 0.0253807106598985
REAC REAC:R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 1.32278922109102e-05 86 14 4 0.285714285714286 0.0465116279069767
REAC REAC:R-HSA-9683610 Maturation of nucleoprotein 1.33153783977011e-05 10 35 3 0.0857142857142857 0.3
REAC REAC:R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 1.39527413049302e-05 88 14 4 0.285714285714286 0.0454545454545455
REAC REAC:R-HSA-453276 Regulation of mitotic cell cycle 1.39527413049302e-05 88 14 4 0.285714285714286 0.0454545454545455
REAC REAC:R-HSA-5687128 MAPK6/MAPK4 signaling 1.42377576404567e-05 89 14 4 0.285714285714286 0.0449438202247191
REAC REAC:R-HSA-1280218 Adaptive Immune System 1.42377576404567e-05 800 24 10 0.416666666666667 0.0125
REAC REAC:R-HSA-69052 Switching of origins to a post-replicative state 1.53715164745847e-05 91 14 4 0.285714285714286 0.043956043956044
REAC REAC:R-HSA-4086400 PCP/CE pathway 1.56756403359168e-05 92 14 4 0.285714285714286 0.0434782608695652
REAC REAC:R-HSA-5689603 UCH proteinases 1.56756403359168e-05 92 14 4 0.285714285714286 0.0434782608695652
REAC REAC:R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 1.6684841020309e-05 94 14 4 0.285714285714286 0.0425531914893617
REAC REAC:R-HSA-8878159 Transcriptional regulation by RUNX3 1.6684841020309e-05 94 14 4 0.285714285714286 0.0425531914893617
REAC REAC:R-HSA-5607764 CLEC7A (Dectin-1) signaling 1.86965748340237e-05 97 14 4 0.285714285714286 0.0412371134020619
REAC REAC:R-HSA-202424 Downstream TCR signaling 1.92559795415608e-05 98 14 4 0.285714285714286 0.0408163265306122
REAC REAC:R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 2.06365034053919e-05 100 14 4 0.285714285714286 0.04
REAC REAC:R-HSA-9020702 Interleukin-1 signaling 2.12325406842204e-05 101 14 4 0.285714285714286 0.0396039603960396
REAC REAC:R-HSA-382556 ABC-family proteins mediated transport 2.27047430450296e-05 103 14 4 0.285714285714286 0.0388349514563107
REAC REAC:R-HSA-5610787 Hedgehog 'off' state 3.24570843134571e-05 113 14 4 0.285714285714286 0.0353982300884956
REAC REAC:R-HSA-69239 Synthesis of DNA 4.03118469066716e-05 120 14 4 0.285714285714286 0.0333333333333333
REAC REAC:R-HSA-202403 TCR signaling 4.03118469066716e-05 120 14 4 0.285714285714286 0.0333333333333333
REAC REAC:R-HSA-162909 Host Interactions of HIV factors 4.68791126347501e-05 125 14 4 0.285714285714286 0.032
REAC REAC:R-HSA-69306 DNA Replication 5.09488402509587e-05 128 14 4 0.285714285714286 0.03125
REAC REAC:R-HSA-69206 G1/S Transition 5.52533585191484e-05 131 14 4 0.285714285714286 0.0305343511450382
REAC REAC:R-HSA-5621481 C-type lectin receptors (CLRs) 6.27553904011787e-05 136 14 4 0.285714285714286 0.0294117647058824
REAC REAC:R-HSA-2871837 FCERI mediated NF-kB activation 6.27553904011787e-05 136 14 4 0.285714285714286 0.0294117647058824
REAC REAC:R-HSA-446652 Interleukin-1 family signaling 6.51544935672814e-05 138 14 4 0.285714285714286 0.0289855072463768
REAC REAC:R-HSA-6807070 PTEN Regulation 6.51544935672814e-05 138 14 4 0.285714285714286 0.0289855072463768
REAC REAC:R-HSA-3858494 Beta-catenin independent WNT signaling 7.42173191183061e-05 143 14 4 0.285714285714286 0.027972027972028
REAC REAC:R-HSA-197264 Nicotinamide salvaging 7.8749316692806e-05 19 35 3 0.0857142857142857 0.157894736842105
REAC REAC:R-HSA-453279 Mitotic G1 phase and G1/S transition 8.25248257809045e-05 148 14 4 0.285714285714286 0.027027027027027
REAC REAC:R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 8.25248257809045e-05 308 14 5 0.357142857142857 0.0162337662337662
REAC REAC:R-HSA-5358351 Signaling by Hedgehog 8.31527043368888e-05 149 14 4 0.285714285714286 0.0268456375838926
REAC REAC:R-HSA-69481 G2/M Checkpoints 8.31527043368888e-05 149 14 4 0.285714285714286 0.0268456375838926
REAC REAC:R-HSA-877300 Interferon gamma signaling 8.58293204256486e-05 87 46 5 0.108695652173913 0.0574712643678161
REAC REAC:R-HSA-69242 S Phase 0.000113306741515702 162 14 4 0.285714285714286 0.0246913580246914
REAC REAC:R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.000117798405483904 164 14 4 0.285714285714286 0.024390243902439
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.000137452160943961 171 14 4 0.285714285714286 0.0233918128654971
REAC REAC:R-HSA-5619115 Disorders of transmembrane transporters 0.000142551016690737 173 14 4 0.285714285714286 0.023121387283237
REAC REAC:R-HSA-109581 Apoptosis 0.000144503316881296 174 14 4 0.285714285714286 0.0229885057471264
REAC REAC:R-HSA-5357801 Programmed Cell Death 0.000153111358739689 177 14 4 0.285714285714286 0.0225988700564972
REAC REAC:R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.000169182011069049 182 14 4 0.285714285714286 0.021978021978022
REAC REAC:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.000180543036077682 371 14 5 0.357142857142857 0.0134770889487871
REAC REAC:R-HSA-2467813 Separation of Sister Chromatids 0.000188659760466486 188 14 4 0.285714285714286 0.0212765957446809
REAC REAC:R-HSA-69275 G2/M Transition 0.000218083210781848 196 14 4 0.285714285714286 0.0204081632653061
REAC REAC:R-HSA-201681 TCF dependent signaling in response to WNT 0.000218083210781848 196 14 4 0.285714285714286 0.0204081632653061
REAC REAC:R-HSA-453274 Mitotic G2-G2/M phases 0.0002230954244955 198 14 4 0.285714285714286 0.0202020202020202
REAC REAC:R-HSA-9683701 Translation of structural proteins 0.0002230954244955 28 35 3 0.0857142857142857 0.107142857142857
REAC REAC:R-HSA-8878171 Transcriptional regulation by RUNX1 0.000228190580273364 200 14 4 0.285714285714286 0.02
REAC REAC:R-HSA-5689880 Ub-specific processing proteases 0.000228190580273364 200 14 4 0.285714285714286 0.02
REAC REAC:R-HSA-196807 Nicotinate metabolism 0.000295262093317466 31 35 3 0.0857142857142857 0.0967741935483871
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 0.000307881778469477 217 14 4 0.285714285714286 0.0184331797235023
REAC REAC:R-HSA-162906 HIV Infection 0.000357275546855942 226 14 4 0.285714285714286 0.0176991150442478
REAC REAC:R-HSA-68882 Mitotic Anaphase 0.00036670048746591 228 14 4 0.285714285714286 0.0175438596491228
REAC REAC:R-HSA-2555396 Mitotic Metaphase and Anaphase 0.000370019791284381 229 14 4 0.285714285714286 0.0174672489082969
REAC REAC:R-HSA-449147 Signaling by Interleukins 0.000387680426046365 446 14 5 0.357142857142857 0.0112107623318386
REAC REAC:R-HSA-8951664 Neddylation 0.000389437276514447 233 14 4 0.285714285714286 0.0171673819742489
REAC REAC:R-HSA-1257604 PIP3 activates AKT signaling 0.000498739677953244 249 14 4 0.285714285714286 0.0160642570281124
REAC REAC:R-HSA-5673001 RAF/MAP kinase cascade 0.000619133869161439 264 14 4 0.285714285714286 0.0151515151515152
REAC REAC:R-HSA-5684996 MAPK1/MAPK3 signaling 0.000660109866942938 269 14 4 0.285714285714286 0.0148698884758364
REAC REAC:R-HSA-69620 Cell Cycle Checkpoints 0.000673962088934382 271 14 4 0.285714285714286 0.014760147601476
REAC REAC:R-HSA-5688426 Deubiquitination 0.00071725188628797 276 14 4 0.285714285714286 0.0144927536231884
REAC REAC:R-HSA-9607240 FLT3 Signaling 0.000731829558342153 278 14 4 0.285714285714286 0.0143884892086331
REAC REAC:R-HSA-9006925 Intracellular signaling by second messengers 0.000842025619345137 289 14 4 0.285714285714286 0.013840830449827
REAC REAC:R-HSA-195721 Signaling by WNT 0.000869355977164227 292 14 4 0.285714285714286 0.0136986301369863
REAC REAC:R-HSA-5683057 MAPK family signaling cascades 0.001041470580954 308 14 4 0.285714285714286 0.012987012987013
REAC REAC:R-HSA-9678108 SARS-CoV-1 Infection 0.00107674168223322 50 35 3 0.0857142857142857 0.06
REAC REAC:R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.00123599512554593 181 24 4 0.166666666666667 0.0220994475138122
REAC REAC:R-HSA-5663205 Infectious disease 0.00190008792768969 815 35 9 0.257142857142857 0.0110429447852761
REAC REAC:R-HSA-451927 Interleukin-2 family signaling 0.0019255703962737 44 49 3 0.0612244897959184 0.0681818181818182
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 0.00193681380464598 368 14 4 0.285714285714286 0.0108695652173913
REAC REAC:R-HSA-68886 M Phase 0.0019829839259423 371 14 4 0.285714285714286 0.0107816711590297
REAC REAC:R-HSA-9679506 SARS-CoV Infections 0.00462141827403338 85 35 3 0.0857142857142857 0.0352941176470588
REAC REAC:R-HSA-69278 Cell Cycle, Mitotic 0.00627087205874893 513 14 4 0.285714285714286 0.00779727095516569
REAC REAC:R-HSA-2262752 Cellular responses to stress 0.00774862850579773 546 14 4 0.285714285714286 0.00732600732600733
REAC REAC:R-HSA-422475 Axon guidance 0.00785232881941968 549 14 4 0.285714285714286 0.00728597449908925
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 0.00837714367456619 560 14 4 0.285714285714286 0.00714285714285714
REAC REAC:R-HSA-9675108 Nervous system development 0.00909173896459566 574 14 4 0.285714285714286 0.00696864111498258
REAC REAC:R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.0113312575554622 120 35 3 0.0857142857142857 0.025
REAC REAC:R-HSA-1640170 Cell Cycle 0.0126387760076712 642 14 4 0.285714285714286 0.00623052959501558
REAC REAC:R-HSA-8953854 Metabolism of RNA 0.0135799103340282 658 14 4 0.285714285714286 0.0060790273556231
REAC REAC:R-HSA-1643685 Disease 0.0135799103340282 1509 14 6 0.428571428571429 0.00397614314115308
REAC REAC:R-HSA-382551 Transport of small molecules 0.0179160028495721 718 14 4 0.285714285714286 0.00557103064066852
REAC REAC:R-HSA-212436 Generic Transcription Pathway 0.0208742797456252 1180 14 5 0.357142857142857 0.00423728813559322
REAC REAC:R-HSA-73857 RNA Polymerase II Transcription 0.0298742884574334 1301 14 5 0.357142857142857 0.00384319754035357
REAC REAC:R-HSA-196854 Metabolism of vitamins and cofactors 0.0318711634507114 186 35 3 0.0857142857142857 0.0161290322580645
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.036829017128406 474 15 3 0.2 0.00632911392405063
REAC REAC:R-HSA-597592 Post-translational protein modification 0.036829017128406 1377 14 5 0.357142857142857 0.00363108206245461
REAC REAC:R-HSA-392499 Metabolism of proteins 0.0415426526392726 1961 14 6 0.428571428571429 0.00305966343702193
REAC REAC:R-HSA-74160 Gene expression (Transcription) 0.0418030555509442 1435 14 5 0.357142857142857 0.00348432055749129
TF TF:M09957 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN 4.37859549792884e-25 272 63 24 0.380952380952381 0.0882352941176471
TF TF:M11685 Factor: IRF-8; motif: NCGAAACYGAAACYN 5.49492650918786e-22 1617 57 36 0.631578947368421 0.0222634508348794
TF TF:M07216 Factor: IRF1; motif: NNNYASTTTCACTTTCNNTTT 5.49492650918786e-22 440 63 25 0.396825396825397 0.0568181818181818
TF TF:M11664 Factor: IRF-2; motif: NGAAASYGAAAS 1.11964825135148e-20 1651 57 35 0.614035087719298 0.0211992731677771
TF TF:M04788 Factor: IRF-1; motif: STTTCACTTTCNNT 4.33229671599465e-20 536 63 25 0.396825396825397 0.0466417910447761
TF TF:M08887_1 Factor: IRF; motif: NNGAAANTGAAANN; match class: 1 7.33617096991549e-19 73 63 14 0.222222222222222 0.191780821917808
TF TF:M08887 Factor: IRF; motif: NNGAAANTGAAANN 2.57257160314091e-18 1267 57 30 0.526315789473684 0.0236779794790845
TF TF:M11665 Factor: IRF-2; motif: NGAAASYGAAAS 7.46943988028814e-18 2396 57 37 0.649122807017544 0.0154424040066778
TF TF:M09629 Factor: IRF-1; motif: NAAANNGAAAGTGAAASTRN 1.04511969309934e-17 336 63 20 0.317460317460317 0.0595238095238095
TF TF:M11677 Factor: IRF-3; motif: NGGAAACNGAAACCGAAACN 1.46366560324968e-17 470 63 22 0.349206349206349 0.0468085106382979
TF TF:M11686 Factor: IRF-4; motif: NYGAAASYGAAACYN 1.58448191408177e-16 3391 58 41 0.706896551724138 0.0120908286641109
TF TF:M00453 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN 1.58448191408177e-16 3082 38 31 0.815789473684211 0.0100584036340039
TF TF:M11679 Factor: IRF-7; motif: NCGAAANCGAAANYN 1.58448191408177e-16 622 49 21 0.428571428571429 0.0337620578778135
TF TF:M04020 Factor: IRF8; motif: NCGAAACCGAAACT 2.24745064254198e-15 992 38 21 0.552631578947368 0.0211693548387097
TF TF:M11682 Factor: IRF-8; motif: NYGAAASYGAAACYN 2.97989995578391e-15 3795 36 31 0.861111111111111 0.00816864295125165
TF TF:M04014 Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR 4.1710892356669e-15 278 63 17 0.26984126984127 0.0611510791366906
TF TF:M11670 Factor: IRF-5; motif: NYGAAACCGAAACY 8.31221532775328e-15 871 55 23 0.418181818181818 0.026406429391504
TF TF:M11671 Factor: IRF-5; motif: NCGAAACCGAAACY 8.38076554717534e-15 389 34 15 0.441176470588235 0.038560411311054
TF TF:M09956 Factor: IRF-1; motif: NAAANNGAAASTGAAASNRN 3.19297615466382e-14 317 63 17 0.26984126984127 0.0536277602523659
TF TF:M00772 Factor: IRF; motif: RRAANTGAAASYGNV 5.16860665683837e-14 1029 57 24 0.421052631578947 0.0233236151603499
TF TF:M04015 Factor: IRF-4; motif: NCGAAACCGAAACYA 6.97533587321494e-14 2038 35 24 0.685714285714286 0.0117762512266928
TF TF:M11664_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 1.30049121665624e-13 140 63 13 0.206349206349206 0.0928571428571429
TF TF:M11687 Factor: IRF-4; motif: NCGAAACCGAAACYN 1.54064098045413e-13 3595 38 30 0.789473684210526 0.00834492350486787
TF TF:M10080 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN 1.74827126920993e-13 356 63 17 0.26984126984127 0.047752808988764
TF TF:M11685_1 Factor: IRF-8; motif: NCGAAACYGAAACYN; match class: 1 4.19878402639956e-13 118 45 11 0.244444444444444 0.0932203389830508
TF TF:M08775_1 Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 6.61278736829607e-13 2761 55 33 0.6 0.0119521912350598
TF TF:M04018 Factor: IRF7; motif: NCGAAARYGAAANT 8.7830218893947e-13 619 57 19 0.333333333333333 0.0306946688206785
TF TF:M11683 Factor: IRF-8; motif: NCGAAACCGAAACYN 8.7830218893947e-13 4690 36 31 0.861111111111111 0.00660980810234542
TF TF:M11680 Factor: IRF-9; motif: NYGAAACYGAAACYN 9.06048142214604e-13 128 45 11 0.244444444444444 0.0859375
TF TF:M00453_1 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN; match class: 1 9.7303870663553e-13 332 63 16 0.253968253968254 0.0481927710843374
TF TF:M11676 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN 1.122101950327e-12 562 63 19 0.301587301587302 0.0338078291814947
TF TF:M09733 Factor: STAT2; motif: NRGAAANNGAAACTNA 1.26750771644791e-12 2842 55 33 0.6 0.0116115411681914
TF TF:M11681 Factor: IRF-9; motif: NCGAAACYGAAACYN 2.42373758652817e-12 97 45 10 0.222222222222222 0.103092783505155
TF TF:M00258 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC 3.04877739424331e-12 823 48 19 0.395833333333333 0.023086269744836
TF TF:M11665_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 5.31105927079744e-12 246 63 14 0.222222222222222 0.0569105691056911
TF TF:M11684 Factor: IRF-8; motif: NYGAAACYGAAACTN 6.85181819922622e-12 4664 58 41 0.706896551724138 0.00879073756432247
TF TF:M11672 Factor: IRF-5; motif: NCGAAACCGAAACY 1.92204567445853e-11 120 45 10 0.222222222222222 0.0833333333333333
TF TF:M11683_1 Factor: IRF-8; motif: NCGAAACCGAAACYN; match class: 1 4.13925280350916e-11 814 55 19 0.345454545454545 0.0233415233415233
TF TF:M00699 Factor: ICSBP; motif: RAARTGAAACTG 8.45988485197704e-11 1184 52 21 0.403846153846154 0.0177364864864865
TF TF:M11686_1 Factor: IRF-4; motif: NYGAAASYGAAACYN; match class: 1 8.45988485197704e-11 452 63 16 0.253968253968254 0.0353982300884956
TF TF:M11684_1 Factor: IRF-8; motif: NYGAAACYGAAACTN; match class: 1 8.45988485197704e-11 832 63 20 0.317460317460317 0.0240384615384615
TF TF:M11687_1 Factor: IRF-4; motif: NCGAAACCGAAACYN; match class: 1 9.25036797239085e-11 474 35 13 0.371428571428571 0.0274261603375527
TF TF:M11682_1 Factor: IRF-8; motif: NYGAAASYGAAACYN; match class: 1 9.60445822100307e-11 543 63 17 0.26984126984127 0.0313075506445672
TF TF:M04015_1 Factor: IRF-4; motif: NCGAAACCGAAACYA; match class: 1 2.61569359822686e-10 158 45 10 0.222222222222222 0.0632911392405063
TF TF:M00699_1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 1.44759762697094e-09 47 45 7 0.155555555555556 0.148936170212766
TF TF:M09958 Factor: IRF-3; motif: RAAARGGAAANNGAAASNGA 3.99046625408259e-09 589 63 16 0.253968253968254 0.0271646859083192
TF TF:M00258_1 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC; match class: 1 6.79501952822166e-09 30 45 6 0.133333333333333 0.2
TF TF:M00972_1 Factor: IRF; motif: RAAANTGAAAN; match class: 1 1.02657719587613e-08 205 36 9 0.25 0.0439024390243902
TF TF:M07045 Factor: IRF-1; motif: NNRAAANNGAAASN 1.10156783357191e-08 535 63 15 0.238095238095238 0.0280373831775701
TF TF:M00972 Factor: IRF; motif: RAAANTGAAAN 2.99416371377921e-08 1979 57 24 0.421052631578947 0.0121273370389085
TF TF:M07323 Factor: IRF-4; motif: KRAAMNGAAANYN 9.94106219647748e-08 938 51 16 0.313725490196078 0.0170575692963753
TF TF:M08775 Factor: IRF-2; motif: NAANYGAAASYR 1.55030236746472e-07 8370 53 44 0.830188679245283 0.00525686977299881
TF TF:M04016 Factor: IRF5; motif: CCGAAACCGAAACY 1.87328497536412e-07 314 45 10 0.222222222222222 0.0318471337579618
TF TF:M11673 Factor: IRF-5; motif: NCGAAACCGAAACY 3.44293008888959e-07 57 21 5 0.238095238095238 0.087719298245614
TF TF:M09733_1 Factor: STAT2; motif: NRGAAANNGAAACTNA; match class: 1 4.68743455421357e-07 367 55 11 0.2 0.0299727520435967
TF TF:M04020_1 Factor: IRF8; motif: NCGAAACCGAAACT; match class: 1 5.57539127961931e-06 45 45 5 0.111111111111111 0.111111111111111
TF TF:M04017 Factor: IRF5; motif: NACCGAAACYA 5.57539127961931e-06 195 22 6 0.272727272727273 0.0307692307692308
TF TF:M09957_1 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN; match class: 1 5.7543006179022e-06 22 35 4 0.114285714285714 0.181818181818182
TF TF:M10080_1 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN; match class: 1 1.39366530703696e-05 11 20 3 0.15 0.272727272727273
TF TF:M07045_1 Factor: IRF-1; motif: NNRAAANNGAAASN; match class: 1 1.90375772743278e-05 19 55 4 0.0727272727272727 0.210526315789474
TF TF:M00063 Factor: IRF-2; motif: GAAAAGYGAAASY 0.000135592014488389 685 63 12 0.19047619047619 0.0175182481751825
TF TF:M09745 Factor: HELIOS; motif: RNARRRGGAASTGARAN 0.000147493736883593 3582 35 19 0.542857142857143 0.00530429927414852
TF TF:M01279 Factor: IRF-3; motif: NBNBTTTCSCTTT 0.000211712190445516 1647 57 17 0.298245614035088 0.0103217972070431
TF TF:M09745_1 Factor: HELIOS; motif: RNARRRGGAASTGARAN; match class: 1 0.000308398559605477 495 63 10 0.158730158730159 0.0202020202020202
TF TF:M00772_1 Factor: IRF; motif: RRAANTGAAASYGNV; match class: 1 0.000738954161274742 57 45 4 0.0888888888888889 0.0701754385964912
TF TF:M06507 Factor: ZFP90; motif: NGGGASTTTAKA 0.000986251785437264 40 22 3 0.136363636363636 0.075
TF TF:M00155 Factor: ARP-1; motif: TGARCCYTTGAMCCCW 0.00132331483728601 5581 28 19 0.678571428571429 0.00340440781222003
TF TF:M04054 Factor: NF-kappaB; motif: AGGGGAWTCCCCT 0.00141357176442649 2924 16 10 0.625 0.00341997264021888
TF TF:M04054_1 Factor: NF-kappaB; motif: AGGGGAWTCCCCT; match class: 1 0.00284797776908009 1295 16 7 0.4375 0.00540540540540541
TF TF:M04903_1 Factor: HNF-4alpha; motif: AGTCCAAR; match class: 1 0.00292641671791932 1534 4 4 1 0.00260756192959583
TF TF:M11676_1 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN; match class: 1 0.00406555890304462 41 35 3 0.0857142857142857 0.0731707317073171
TF TF:M00346 Factor: GATA-1; motif: NCWGATAACA 0.00406555890304462 4376 33 18 0.545454545454545 0.00411334552102377
TF TF:M12286 Factor: ZNF647; motif: NYAGGCCYAC 0.00473168099615618 6231 16 13 0.8125 0.00208634248114267
TF TF:M03793 Factor: IRF-7; motif: AARGGAAANNGAA 0.00479955772506573 1987 16 8 0.5 0.00402617010568697
TF TF:M09629_1 Factor: IRF-1; motif: NAAANNGAAAGTGAAASTRN; match class: 1 0.00526472965693299 29 55 3 0.0545454545454545 0.103448275862069
TF TF:M03547 Factor: ER-alpha; motif: TGACCYN 0.00531707821365561 4712 15 11 0.733333333333333 0.00233446519524618
TF TF:M00208 Factor: NF-kappaB; motif: NGGGACTTTCCA 0.00531707821365561 3757 35 17 0.485714285714286 0.00452488687782805
TF TF:M11670_1 Factor: IRF-5; motif: NYGAAACCGAAACY; match class: 1 0.00534606751602465 36 45 3 0.0666666666666667 0.0833333333333333
TF TF:M00208_1 Factor: NF-kappaB; motif: NGGGACTTTCCA; match class: 1 0.00613874368091261 604 16 5 0.3125 0.00827814569536424
TF TF:M03821 Factor: ER-beta; motif: ANNSTGACCYRGNN 0.00646784790467714 6456 16 13 0.8125 0.00201363073110285
TF TF:M07323_1 Factor: IRF-4; motif: KRAAMNGAAANYN; match class: 1 0.0065609986448349 39 45 3 0.0666666666666667 0.0769230769230769
TF TF:M00051_1 Factor: NF-kappaB; motif: GGGGATYCCC; match class: 1 0.00735435910727786 2797 42 16 0.380952380952381 0.00572041473006793
TF TF:M00459_1 Factor: STAT5B; motif: NAWTTCYNGGAAWTN; match class: 1 0.00804445659863018 1896 32 11 0.34375 0.00580168776371308
TF TF:M04756_1 Factor: sin3A; motif: TGTCCNNGGTGCTG; match class: 1 0.00986636108890243 7714 23 18 0.782608695652174 0.00233341975628727
TF TF:M09808 Factor: KLF4; motif: MCACACCCTNN 0.0111857025491563 3799 16 10 0.625 0.00263227165043432
TF TF:M03557_1 Factor: P50; motif: GGRRANTCCCNN; match class: 1 0.012373295654963 1292 33 9 0.272727272727273 0.00696594427244582
TF TF:M07314 Factor: Blimp-1; motif: RGRAAGNGAAAG 0.0132470999561067 1460 57 13 0.228070175438596 0.0089041095890411
TF TF:M07229 Factor: STAT3; motif: NTTCYKGGAAN 0.0171125044019112 3717 32 15 0.46875 0.00403551251008878
TF TF:M00054 Factor: NF-kappaB; motif: GGGAMTTYCC 0.0171125044019112 2444 16 8 0.5 0.00327332242225859
TF TF:M11807 Factor: RAR-gamma; motif: RAGGTCATGACCTY 0.0172272502125163 2046 23 9 0.391304347826087 0.00439882697947214
TF TF:M08952_1 Factor: NF-KAPPAB1; motif: NGGKRNTTYCCCN; match class: 1 0.017510657944799 3457 18 10 0.555555555555556 0.00289268151576511
TF TF:M11675 Factor: IRF-3; motif: KCNGTTTCSNSGAAACCGAAACN 0.017510657944799 4655 64 28 0.4375 0.00601503759398496
TF TF:M11674_1 Factor: IRF-3; motif: GCNGTTTCCWGGAAACNGAAAC; match class: 1 0.0186410913066678 1663 46 12 0.260869565217391 0.00721587492483464
TF TF:M10079_1 Factor: STAT1; motif: NCCNTTTCCNGGAAANCNC; match class: 1 0.0190134150733743 1164 31 8 0.258064516129032 0.00687285223367698
TF TF:M11674 Factor: IRF-3; motif: GCNGTTTCCWGGAAACNGAAAC 0.0192560211392596 4623 41 20 0.48780487804878 0.00432619511139952
TF TF:M03916 Factor: PRDM1; motif: NRAAAGTGAAAGTNN 0.0192560211392596 948 57 10 0.175438596491228 0.0105485232067511
TF TF:M09664_1 Factor: STAT3; motif: NTTCCYGGAAN; match class: 1 0.0219445033263849 1875 31 10 0.32258064516129 0.00533333333333333
TF TF:M01721 Factor: PUR1; motif: GGGNCAGNN 0.0245186182245437 9145 10 10 1 0.00109349371241115
TF TF:M00774_1 Factor: NF-kappaB; motif: NGGGANTTYCCMNNNN; match class: 1 0.0245507988725342 192 16 3 0.1875 0.015625
TF TF:M10170 Factor: ZNF85; motif: ANAGAARWCTGMWGKAATCT 0.0246863044431255 181 17 3 0.176470588235294 0.0165745856353591
TF TF:M07228 Factor: STAT1; motif: NTTCYRGGAAA 0.0252252665233784 1919 31 10 0.32258064516129 0.00521104742053153
TF TF:M08890 Factor: MYB; motif: NNAACTGN 0.0292544996363393 1355 36 9 0.25 0.00664206642066421
TF TF:M11800_1 Factor: NR1B2; motif: RAGGTCRTGACCTY; match class: 1 0.0292544996363393 987 22 6 0.272727272727273 0.0060790273556231
TF TF:M00459 Factor: STAT5B; motif: NAWTTCYNGGAAWTN 0.0292950991803114 3076 32 13 0.40625 0.00422626788036411
TF TF:M07355 Factor: GR; motif: AGAACAN 0.0295264153185388 5862 17 12 0.705882352941177 0.00204708290685773
TF TF:M00051 Factor: NF-kappaB; motif: GGGGATYCCC 0.0298546697789997 6413 16 12 0.75 0.00187119912677374
TF TF:M12156_1 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN; match class: 1 0.030324760185041 1002 22 6 0.272727272727273 0.00598802395209581
TF TF:M12155_1 Factor: Sp2; motif: NTWAGTCCCGCCCMCTT; match class: 1 0.0310312683362538 1008 22 6 0.272727272727273 0.00595238095238095
TF TF:M00225_1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 1 0.0310622942421465 1922 32 10 0.3125 0.00520291363163371
TF TF:M07256 Factor: FXR:RXR; motif: RGGTCANTGACCTN 0.0316735585316508 1642 25 8 0.32 0.0048721071863581
TF TF:M11853 Factor: RORgamma; motif: TAGGTCRTGACCTA 0.0318118295985458 159 22 3 0.136363636363636 0.0188679245283019
TF TF:M01043_1 Factor: CSX; motif: TSYCACTTSM; match class: 1 0.0318118295985458 1199 13 5 0.384615384615385 0.00417014178482068
TF TF:M09668 Factor: RelA-p65; motif: GGGRNTTTCCM 0.0318118295985458 3576 16 9 0.5625 0.00251677852348993
TF TF:M00457_1 Factor: STAT5A; motif: NAWTTCYNGGAANYN; match class: 1 0.0318118295985458 1589 32 9 0.28125 0.00566393958464443
TF TF:M01279_1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 1 0.0332389020429053 101 35 3 0.0857142857142857 0.0297029702970297
TF TF:M00947_1 Factor: CP2/LBP-1c/LSF; motif: GCTGGNTNGNNCYNG; match class: 1 0.0340042264839873 2651 56 17 0.303571428571429 0.00641267446246699
TF TF:M08891 Factor: NFKAPPAB; motif: NNGGGANTTCCCN 0.0366438229721024 2110 41 12 0.292682926829268 0.00568720379146919
TF TF:M00947 Factor: CP2/LBP-1c/LSF; motif: GCTGGNTNGNNCYNG 0.0384790692826861 8413 58 37 0.637931034482759 0.0043979555449899
TF TF:M00979 Factor: Pax-6; motif: CTGACCTGGAACTM 0.0398263189381838 9690 23 19 0.826086956521739 0.00196078431372549
TF TF:M05386 Factor: KLF17; motif: NGGGCGG 0.0413687271715166 7900 23 17 0.739130434782609 0.00215189873417722
TF TF:M05499 Factor: LKLF; motif: NGGGCGG 0.0413687271715166 7900 23 17 0.739130434782609 0.00215189873417722
TF TF:M11816 Factor: T3R-beta; motif: NRGGTCAAAGGTCAN 0.0454287623023832 11742 18 17 0.944444444444444 0.00144779424288878
TF TF:M10526_1 Factor: Blimp-1; motif: RRGNGAAAGNRANNN; match class: 1 0.0458334936435998 286 55 5 0.0909090909090909 0.0174825174825175
TF TF:M07204 Factor: AR; motif: ARGAACANNNTGTNC 0.0458334936435998 4906 18 11 0.611111111111111 0.00224215246636771
WP WP:WP619 Type II interferon signaling (IFNG) 1.9077335003594e-09 37 46 8 0.173913043478261 0.216216216216216
WP WP:WP4197 The human immune response to tuberculosis 1.9077335003594e-09 23 46 7 0.152173913043478 0.304347826086957
WP WP:WP183 Proteasome Degradation 9.9966269273238e-09 64 22 7 0.318181818181818 0.109375
WP WP:WP4877 Host-pathogen interaction of human corona viruses - MAPK signaling 2.18862758229256e-06 36 3 3 1 0.0833333333333333
WP WP:WP4217 Ebola Virus Pathway on Host 0.000111441753708175 130 28 6 0.214285714285714 0.0461538461538462
WP WP:WP4868 Type I Interferon Induction and Signaling During SARS-CoV-2 Infection 0.000374146142905048 29 46 4 0.0869565217391304 0.137931034482759
WP WP:WP4880 Host-pathogen interaction of human corona viruses - Interferon induction 0.000542804970488949 33 46 4 0.0869565217391304 0.121212121212121
WP WP:WP2113 Type III interferon signaling 0.000700559968071064 10 63 3 0.0476190476190476 0.3
WP WP:WP2328 Allograft Rejection 0.00104529225320668 88 22 4 0.181818181818182 0.0454545454545455
WP WP:WP4341 Non-genomic actions of 1,25 dihydroxyvitamin D3 0.0019836039874138 70 33 4 0.121212121212121 0.0571428571428571
WP WP:WP5039 SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response 0.00987786515045689 68 24 3 0.125 0.0441176470588235
WP WP:WP4558 Overview of interferons-mediated signaling pathway 0.0237910721251391 37 63 3 0.0476190476190476 0.0810810810810811

pEpi30 transcription factor target enrichment of top program genes

TF enrichment of pEpi30
Possible regulators of activation of pEpi30 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.