pS03 program activity among Stromal cells

Activation of pS03
pS03 gene program activation in Stromal cells.
Gene program activation of pS03 by different cell subtypes
pS03 gene program activation among cells of different subtypes (Stromal cells).

pS03 top program genes

Top genes of pS03 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pS03 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pS03
pS03 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:486 WIP-WASp-actin-myosin-IIa complex 0.000132569832236128 6 78 4 0.0512820512820513 0.666666666666667
CORUM CORUM:2255 Cofilin-actin-CAP1 complex 0.000132569832236128 3 56 3 0.0535714285714286 1
CORUM CORUM:5177 Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) 0.00116659998236979 11 25 3 0.12 0.272727272727273
GO:BP GO:0030029 actin filament-based process 2.08334901012836e-26 808 109 43 0.394495412844037 0.0532178217821782
GO:BP GO:0030036 actin cytoskeleton organization 2.85467271683048e-24 709 109 39 0.357798165137615 0.0550070521861777
GO:BP GO:0006936 muscle contraction 1.48322434440789e-19 364 106 27 0.254716981132075 0.0741758241758242
GO:BP GO:0003012 muscle system process 6.59538237339393e-18 471 106 28 0.264150943396226 0.059447983014862
GO:BP GO:0007010 cytoskeleton organization 3.75743830951212e-17 1423 110 43 0.390909090909091 0.0302178496134926
GO:BP GO:0070527 platelet aggregation 9.74885775722315e-14 64 27 9 0.333333333333333 0.140625
GO:BP GO:0007015 actin filament organization 4.53599569376893e-13 445 107 23 0.214953271028037 0.051685393258427
GO:BP GO:0097435 supramolecular fiber organization 4.64721894352507e-13 734 107 28 0.261682242990654 0.0381471389645777
GO:BP GO:0034109 homotypic cell-cell adhesion 1.18569133451484e-12 87 27 9 0.333333333333333 0.103448275862069
GO:BP GO:0006928 movement of cell or subcellular component 1.45494750130337e-11 2311 124 49 0.395161290322581 0.0212029424491562
GO:BP GO:0042060 wound healing 5.641062189397e-11 549 33 14 0.424242424242424 0.0255009107468124
GO:BP GO:0030168 platelet activation 2.44511741306178e-10 160 27 9 0.333333333333333 0.05625
GO:BP GO:0009611 response to wounding 7.67083927339789e-10 674 33 14 0.424242424242424 0.0207715133531157
GO:BP GO:0048870 cell motility 1.88369094347843e-09 1828 129 41 0.317829457364341 0.0224288840262582
GO:BP GO:0051674 localization of cell 1.88369094347843e-09 1828 129 41 0.317829457364341 0.0224288840262582
GO:BP GO:0061061 muscle structure development 2.21117986167484e-09 645 85 20 0.235294117647059 0.0310077519379845
GO:BP GO:0040011 locomotion 2.60412291269423e-09 2028 124 42 0.338709677419355 0.0207100591715976
GO:BP GO:0007155 cell adhesion 6.11922794179444e-09 1492 94 30 0.319148936170213 0.0201072386058981
GO:BP GO:0022610 biological adhesion 6.50974288290037e-09 1499 94 30 0.319148936170213 0.0200133422281521
GO:BP GO:0009653 anatomical structure morphogenesis 8.73864371010659e-09 2797 94 41 0.436170212765957 0.0146585627457991
GO:BP GO:0031032 actomyosin structure organization 2.19889147714996e-08 199 107 13 0.121495327102804 0.0653266331658292
GO:BP GO:0032970 regulation of actin filament-based process 4.03269157857734e-08 406 109 17 0.155963302752294 0.041871921182266
GO:BP GO:0016477 cell migration 8.84355799763089e-08 1649 124 35 0.282258064516129 0.0212249848392965
GO:BP GO:0007596 blood coagulation 1.24107652291427e-07 347 27 9 0.333333333333333 0.0259365994236311
GO:BP GO:0007599 hemostasis 1.31769179789528e-07 351 27 9 0.333333333333333 0.0256410256410256
GO:BP GO:0050817 coagulation 1.36535880435289e-07 354 27 9 0.333333333333333 0.0254237288135593
GO:BP GO:0030048 actin filament-based movement 1.44102426720656e-07 152 106 11 0.10377358490566 0.0723684210526316
GO:BP GO:0048729 tissue morphogenesis 1.98377570530641e-07 667 50 14 0.28 0.0209895052473763
GO:BP GO:0000902 cell morphogenesis 1.99177656479817e-07 1037 94 23 0.24468085106383 0.0221793635486982
GO:BP GO:0032956 regulation of actin cytoskeleton organization 4.7695524573211e-07 366 109 15 0.137614678899083 0.040983606557377
GO:BP GO:0022604 regulation of cell morphogenesis 5.45638609639455e-07 309 93 13 0.139784946236559 0.0420711974110032
GO:BP GO:0098609 cell-cell adhesion 9.5598636012734e-07 894 31 12 0.387096774193548 0.0134228187919463
GO:BP GO:0000904 cell morphogenesis involved in differentiation 9.5598636012734e-07 749 36 12 0.333333333333333 0.0160213618157543
GO:BP GO:0030049 muscle filament sliding 1.93478193150862e-06 39 15 4 0.266666666666667 0.102564102564103
GO:BP GO:0033275 actin-myosin filament sliding 1.93478193150862e-06 39 15 4 0.266666666666667 0.102564102564103
GO:BP GO:0003008 system process 2.51110078246601e-06 2293 35 18 0.514285714285714 0.00784997819450502
GO:BP GO:0031589 cell-substrate adhesion 2.51110078246601e-06 367 107 14 0.130841121495327 0.0381471389645777
GO:BP GO:0050878 regulation of body fluid levels 2.51110078246601e-06 514 27 9 0.333333333333333 0.0175097276264591
GO:BP GO:0070252 actin-mediated cell contraction 2.66840994600835e-06 123 15 5 0.333333333333333 0.040650406504065
GO:BP GO:0051017 actin filament bundle assembly 2.6779307218391e-06 161 107 10 0.0934579439252336 0.062111801242236
GO:BP GO:0061572 actin filament bundle organization 3.11314048172852e-06 164 107 10 0.0934579439252336 0.0609756097560976
GO:BP GO:0032502 developmental process 3.3286901794729e-06 6628 124 75 0.604838709677419 0.0113156306578153
GO:BP GO:1902905 positive regulation of supramolecular fiber organization 3.80043504926453e-06 214 64 9 0.140625 0.0420560747663551
GO:BP GO:0010810 regulation of cell-substrate adhesion 5.0496396296631e-06 222 107 11 0.102803738317757 0.0495495495495495
GO:BP GO:0030043 actin filament fragmentation 5.13261907153574e-06 4 51 3 0.0588235294117647 0.75
GO:BP GO:0006939 smooth muscle contraction 5.21061405644227e-06 110 92 8 0.0869565217391304 0.0727272727272727
GO:BP GO:0006996 organelle organization 5.76752746590681e-06 4104 113 51 0.451327433628319 0.0124269005847953
GO:BP GO:0060485 mesenchyme development 5.80646724016398e-06 291 124 13 0.104838709677419 0.0446735395189003
GO:BP GO:0051493 regulation of cytoskeleton organization 6.21429526331522e-06 531 109 16 0.146788990825688 0.0301318267419962
GO:BP GO:0051495 positive regulation of cytoskeleton organization 6.21429526331522e-06 231 64 9 0.140625 0.038961038961039
GO:BP GO:0110053 regulation of actin filament organization 6.21429526331522e-06 284 107 12 0.11214953271028 0.0422535211267606
GO:BP GO:0002576 platelet degranulation 7.3130690937792e-06 126 35 6 0.171428571428571 0.0476190476190476
GO:BP GO:0007044 cell-substrate junction assembly 7.57023988664031e-06 101 107 8 0.0747663551401869 0.0792079207920792
GO:BP GO:0048513 animal organ development 7.59185822022451e-06 3672 109 46 0.422018348623853 0.0125272331154684
GO:BP GO:0030334 regulation of cell migration 9.86011671608817e-06 999 113 22 0.194690265486726 0.022022022022022
GO:BP GO:0006937 regulation of muscle contraction 9.99792861190809e-06 170 92 9 0.0978260869565217 0.0529411764705882
GO:BP GO:0048856 anatomical structure development 1.05053790919993e-05 6106 96 57 0.59375 0.00933508024893547
GO:BP GO:0150115 cell-substrate junction organization 1.05053790919993e-05 107 107 8 0.0747663551401869 0.0747663551401869
GO:BP GO:0009888 tissue development 1.05053790919993e-05 2107 96 30 0.3125 0.0142382534409112
GO:BP GO:0010927 cellular component assembly involved in morphogenesis 1.05053790919993e-05 107 107 8 0.0747663551401869 0.0747663551401869
GO:BP GO:0048731 system development 1.37571145714465e-05 5052 113 57 0.504424778761062 0.0112826603325416
GO:BP GO:0032989 cellular component morphogenesis 1.58558171596903e-05 791 112 19 0.169642857142857 0.0240202275600506
GO:BP GO:2000145 regulation of cell motility 1.76476205678216e-05 1061 129 24 0.186046511627907 0.0226201696512724
GO:BP GO:0051270 regulation of cellular component movement 1.76476205678216e-05 1141 129 25 0.193798449612403 0.0219106047326906
GO:BP GO:0032233 positive regulation of actin filament bundle assembly 1.9405013329174e-05 64 44 5 0.113636363636364 0.078125
GO:BP GO:1902903 regulation of supramolecular fiber organization 1.9416839948884e-05 387 107 13 0.121495327102804 0.0335917312661499
GO:BP GO:0048041 focal adhesion assembly 2.85619353878597e-05 85 107 7 0.0654205607476635 0.0823529411764706
GO:BP GO:0090257 regulation of muscle system process 2.91418195463251e-05 257 92 10 0.108695652173913 0.0389105058365759
GO:BP GO:0048468 cell development 2.95438220606869e-05 2100 36 16 0.444444444444444 0.00761904761904762
GO:BP GO:0032501 multicellular organismal process 2.95438220606869e-05 7946 31 27 0.870967741935484 0.00339793606846212
GO:BP GO:0040012 regulation of locomotion 3.24410147930362e-05 1104 129 24 0.186046511627907 0.0217391304347826
GO:BP GO:0090130 tissue migration 3.25809270890977e-05 379 115 13 0.11304347826087 0.0343007915567282
GO:BP GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3.30803542489055e-05 110 124 8 0.0645161290322581 0.0727272727272727
GO:BP GO:0008360 regulation of cell shape 4.60818429475032e-05 154 93 8 0.0860215053763441 0.051948051948052
GO:BP GO:0007160 cell-matrix adhesion 4.71979995048819e-05 235 107 10 0.0934579439252336 0.0425531914893617
GO:BP GO:0034329 cell junction assembly 5.19398221404093e-05 438 35 8 0.228571428571429 0.0182648401826484
GO:BP GO:0030239 myofibril assembly 5.7853339116067e-05 62 106 6 0.0566037735849057 0.0967741935483871
GO:BP GO:1902414 protein localization to cell junction 6.21288417412055e-05 113 33 5 0.151515151515152 0.0442477876106195
GO:BP GO:0150105 protein localization to cell-cell junction 8.11387885427302e-05 22 22 3 0.136363636363636 0.136363636363636
GO:BP GO:0002009 morphogenesis of an epithelium 8.42283108688163e-05 560 50 10 0.2 0.0178571428571429
GO:BP GO:1900024 regulation of substrate adhesion-dependent cell spreading 8.45931970295672e-05 58 68 5 0.0735294117647059 0.0862068965517241
GO:BP GO:0034330 cell junction organization 9.01576701426776e-05 722 40 10 0.25 0.0138504155124654
GO:BP GO:0001667 ameboidal-type cell migration 9.8241860065e-05 494 115 14 0.121739130434783 0.0283400809716599
GO:BP GO:0007517 muscle organ development 9.87483299970797e-05 333 124 12 0.0967741935483871 0.036036036036036
GO:BP GO:0048869 cellular developmental process 9.87483299970797e-05 4428 113 50 0.442477876106195 0.0112917795844625
GO:BP GO:0045216 cell-cell junction organization 0.000103106553868806 216 35 6 0.171428571428571 0.0277777777777778
GO:BP GO:0034446 substrate adhesion-dependent cell spreading 0.000104424948063925 109 68 6 0.0882352941176471 0.055045871559633
GO:BP GO:0008154 actin polymerization or depolymerization 0.000107801357743674 223 74 8 0.108108108108108 0.0358744394618834
GO:BP GO:0030154 cell differentiation 0.000137002814211182 4350 116 50 0.431034482758621 0.0114942528735632
GO:BP GO:0048762 mesenchymal cell differentiation 0.000145478085131256 234 124 10 0.0806451612903226 0.0427350427350427
GO:BP GO:0045214 sarcomere organization 0.000156281963539316 41 51 4 0.0784313725490196 0.0975609756097561
GO:BP GO:0032231 regulation of actin filament bundle assembly 0.000165396266872232 106 44 5 0.113636363636364 0.0471698113207547
GO:BP GO:0051146 striated muscle cell differentiation 0.000165396266872232 289 81 9 0.111111111111111 0.0311418685121107
GO:BP GO:0030335 positive regulation of cell migration 0.000206416057985991 567 94 13 0.138297872340426 0.0229276895943563
GO:BP GO:0045669 positive regulation of osteoblast differentiation 0.000239291620876938 70 124 6 0.0483870967741935 0.0857142857142857
GO:BP GO:0032879 regulation of localization 0.000287219796207808 2872 115 37 0.321739130434783 0.012883008356546
GO:BP GO:0001952 regulation of cell-matrix adhesion 0.000288627038489147 127 107 7 0.0654205607476635 0.0551181102362205
GO:BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000304621366860206 257 124 10 0.0806451612903226 0.0389105058365759
GO:BP GO:2000147 positive regulation of cell motility 0.000305455805410135 591 94 13 0.138297872340426 0.0219966159052453
GO:BP GO:0007275 multicellular organism development 0.000324433792575059 5613 113 57 0.504424778761062 0.0101549973276323
GO:BP GO:0051272 positive regulation of cellular component movement 0.000377206568117404 604 94 13 0.138297872340426 0.021523178807947
GO:BP GO:0042692 muscle cell differentiation 0.000378624905003923 390 85 10 0.117647058823529 0.0256410256410256
GO:BP GO:0040017 positive regulation of locomotion 0.000383112100035883 606 94 13 0.138297872340426 0.0214521452145215
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.000582097741183884 1042 113 19 0.168141592920354 0.0182341650671785
GO:BP GO:0061564 axon development 0.000589052647266917 523 31 7 0.225806451612903 0.0133843212237094
GO:BP GO:0016043 cellular component organization 0.000598896327833435 6566 116 64 0.551724137931034 0.00974718245507158
GO:BP GO:0010811 positive regulation of cell-substrate adhesion 0.000640756414618505 124 85 6 0.0705882352941176 0.0483870967741935
GO:BP GO:0009887 animal organ morphogenesis 0.000647821612346916 1073 50 12 0.24 0.0111835973904939
GO:BP GO:0120036 plasma membrane bounded cell projection organization 0.000670611767614693 1569 78 19 0.243589743589744 0.0121096239643085
GO:BP GO:0010769 regulation of cell morphogenesis involved in differentiation 0.000683297932697976 97 33 4 0.121212121212121 0.0412371134020619
GO:BP GO:0090109 regulation of cell-substrate junction assembly 0.000882016805586937 64 107 5 0.0467289719626168 0.078125
GO:BP GO:0030030 cell projection organization 0.000882016805586937 1609 47 14 0.297872340425532 0.00870105655686762
GO:BP GO:0051893 regulation of focal adhesion assembly 0.000882016805586937 64 107 5 0.0467289719626168 0.078125
GO:BP GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 0.000882016805586937 30 115 4 0.0347826086956522 0.133333333333333
GO:BP GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 0.000882016805586937 30 115 4 0.0347826086956522 0.133333333333333
GO:BP GO:0060537 muscle tissue development 0.00100508741570892 399 10 4 0.4 0.0100250626566416
GO:BP GO:0055002 striated muscle cell development 0.00100913248235068 111 64 5 0.078125 0.045045045045045
GO:BP GO:0060429 epithelium development 0.00100913248235068 1325 50 13 0.26 0.00981132075471698
GO:BP GO:0007163 establishment or maintenance of cell polarity 0.00100913248235068 220 78 7 0.0897435897435897 0.0318181818181818
GO:BP GO:0044057 regulation of system process 0.00103036529867252 623 102 13 0.127450980392157 0.0208667736757624
GO:BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 0.00103036529867252 369 124 11 0.0887096774193548 0.029810298102981
GO:BP GO:0007229 integrin-mediated signaling pathway 0.00104040746226793 111 33 4 0.121212121212121 0.036036036036036
GO:BP GO:0051014 actin filament severing 0.00108351126776681 17 78 3 0.0384615384615385 0.176470588235294
GO:BP GO:0150116 regulation of cell-substrate junction organization 0.00117081569527273 69 107 5 0.0467289719626168 0.072463768115942
GO:BP GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 0.0012851714699962 42 33 3 0.0909090909090909 0.0714285714285714
GO:BP GO:0071840 cellular component organization or biogenesis 0.00140113323137104 6760 116 64 0.551724137931034 0.00946745562130178
GO:BP GO:0030042 actin filament depolymerization 0.00142355844386363 62 64 4 0.0625 0.0645161290322581
GO:BP GO:0034762 regulation of transmembrane transport 0.00159308881425716 588 113 13 0.115044247787611 0.022108843537415
GO:BP GO:0065008 regulation of biological quality 0.00167308204818334 4131 53 25 0.471698113207547 0.00605180343742435
GO:BP GO:0030220 platelet formation 0.00170563518774916 20 78 3 0.0384615384615385 0.15
GO:BP GO:0001837 epithelial to mesenchymal transition 0.00173514076446219 156 121 7 0.0578512396694215 0.0448717948717949
GO:BP GO:1904062 regulation of cation transmembrane transport 0.00173514076446219 360 113 10 0.0884955752212389 0.0277777777777778
GO:BP GO:0014812 muscle cell migration 0.00178548339023805 106 124 6 0.0483870967741935 0.0566037735849057
GO:BP GO:0036344 platelet morphogenesis 0.00191238796940732 21 78 3 0.0384615384615385 0.142857142857143
GO:BP GO:0030155 regulation of cell adhesion 0.0019513329640763 748 92 13 0.141304347826087 0.017379679144385
GO:BP GO:0008064 regulation of actin polymerization or depolymerization 0.0019513329640763 193 70 6 0.0857142857142857 0.0310880829015544
GO:BP GO:0006940 regulation of smooth muscle contraction 0.0019513329640763 65 129 5 0.0387596899224806 0.0769230769230769
GO:BP GO:0030832 regulation of actin filament length 0.00197345708217322 194 70 6 0.0857142857142857 0.0309278350515464
GO:BP GO:0055001 muscle cell development 0.00197345708217322 184 106 7 0.0660377358490566 0.0380434782608696
GO:BP GO:0014912 negative regulation of smooth muscle cell migration 0.00197345708217322 36 124 4 0.032258064516129 0.111111111111111
GO:BP GO:0048662 negative regulation of smooth muscle cell proliferation 0.00198899474326597 70 24 3 0.125 0.0428571428571429
GO:BP GO:0050793 regulation of developmental process 0.00211753213395438 2605 95 28 0.294736842105263 0.0107485604606526
GO:BP GO:0010631 epithelial cell migration 0.00229830776539076 370 115 10 0.0869565217391304 0.027027027027027
GO:BP GO:0090132 epithelium migration 0.00243850986802901 373 115 10 0.0869565217391304 0.0268096514745308
GO:BP GO:0007409 axonogenesis 0.00250402066811306 478 31 6 0.193548387096774 0.0125523012552301
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.00275679602076943 1202 113 19 0.168141592920354 0.0158069883527454
GO:BP GO:0048667 cell morphogenesis involved in neuron differentiation 0.00278398131463744 602 36 7 0.194444444444444 0.0116279069767442
GO:BP GO:0051899 membrane depolarization 0.00295792252613939 89 105 5 0.0476190476190476 0.0561797752808989
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.00308448165363616 1103 124 19 0.153225806451613 0.0172257479601088
GO:BP GO:0043268 positive regulation of potassium ion transport 0.00309506971964976 50 102 4 0.0392156862745098 0.08
GO:BP GO:0090287 regulation of cellular response to growth factor stimulus 0.00312286271232876 315 115 9 0.0782608695652174 0.0285714285714286
GO:BP GO:0090066 regulation of anatomical structure size 0.00325324824069722 518 104 11 0.105769230769231 0.0212355212355212
GO:BP GO:0022607 cellular component assembly 0.00327416661912818 3010 107 33 0.308411214953271 0.0109634551495017
GO:BP GO:0007043 cell-cell junction assembly 0.00335383866085992 151 35 4 0.114285714285714 0.0264900662251656
GO:BP GO:1904064 positive regulation of cation transmembrane transport 0.00342668665237789 150 102 6 0.0588235294117647 0.04
GO:BP GO:0001775 cell activation 0.00344410555567837 1495 27 9 0.333333333333333 0.00602006688963211
GO:BP GO:0034767 positive regulation of ion transmembrane transport 0.00373131650889865 217 102 7 0.0686274509803922 0.032258064516129
GO:BP GO:0034764 positive regulation of transmembrane transport 0.00373131650889865 217 102 7 0.0686274509803922 0.032258064516129
GO:BP GO:1903034 regulation of response to wounding 0.00396711581791914 169 33 4 0.121212121212121 0.0236686390532544
GO:BP GO:0034332 adherens junction organization 0.00396858527470011 67 33 3 0.0909090909090909 0.0447761194029851
GO:BP GO:0072359 circulatory system development 0.00403780102825457 1194 27 8 0.296296296296296 0.0067001675041876
GO:BP GO:0010638 positive regulation of organelle organization 0.00408748965742385 603 64 9 0.140625 0.0149253731343284
GO:BP GO:0051271 negative regulation of cellular component movement 0.00430569986039557 377 124 10 0.0806451612903226 0.026525198938992
GO:BP GO:0034765 regulation of ion transmembrane transport 0.00449500875521461 583 113 12 0.106194690265487 0.0205831903945112
GO:BP GO:0048812 neuron projection morphogenesis 0.00449500875521461 664 36 7 0.194444444444444 0.0105421686746988
GO:BP GO:0120039 plasma membrane bounded cell projection morphogenesis 0.0050733604229571 678 36 7 0.194444444444444 0.0103244837758112
GO:BP GO:1903036 positive regulation of response to wounding 0.00511206490344952 74 33 3 0.0909090909090909 0.0405405405405405
GO:BP GO:0048858 cell projection morphogenesis 0.00516892676162785 682 36 7 0.194444444444444 0.0102639296187683
GO:BP GO:0045667 regulation of osteoblast differentiation 0.00516892676162785 135 124 6 0.0483870967741935 0.0444444444444444
GO:BP GO:0120031 plasma membrane bounded cell projection assembly 0.00540732849274203 593 68 9 0.132352941176471 0.015177065767285
GO:BP GO:0070925 organelle assembly 0.00540732849274203 895 66 11 0.166666666666667 0.0122905027932961
GO:BP GO:0035239 tube morphogenesis 0.00562826147916663 950 94 14 0.148936170212766 0.0147368421052632
GO:BP GO:0097581 lamellipodium organization 0.00563781033686498 91 68 4 0.0588235294117647 0.043956043956044
GO:BP GO:0032990 cell part morphogenesis 0.00570994947289255 699 36 7 0.194444444444444 0.0100143061516452
GO:BP GO:0032535 regulation of cellular component size 0.00579531517062556 388 104 9 0.0865384615384615 0.0231958762886598
GO:BP GO:0010770 positive regulation of cell morphogenesis involved in differentiation 0.0059573191339299 80 33 3 0.0909090909090909 0.0375
GO:BP GO:0030031 cell projection assembly 0.00610701324688218 607 68 9 0.132352941176471 0.014827018121911
GO:BP GO:0007507 heart development 0.00619960993013742 578 21 5 0.238095238095238 0.00865051903114187
GO:BP GO:0014909 smooth muscle cell migration 0.00634908773589774 93 124 5 0.0403225806451613 0.0537634408602151
GO:BP GO:0033043 regulation of organelle organization 0.00642610211417373 1203 113 18 0.15929203539823 0.0149625935162095
GO:BP GO:0043149 stress fiber assembly 0.00659489174726249 109 107 5 0.0467289719626168 0.0458715596330275
GO:BP GO:0030038 contractile actin filament bundle assembly 0.00659489174726249 109 107 5 0.0467289719626168 0.0458715596330275
GO:BP GO:0051179 localization 0.00667657958553705 6901 81 46 0.567901234567901 0.0066657006230981
GO:BP GO:0002064 epithelial cell development 0.0068109769830904 218 31 4 0.129032258064516 0.018348623853211
GO:BP GO:0006950 response to stress 0.00721701652026698 4170 34 17 0.5 0.00407673860911271
GO:BP GO:0007179 transforming growth factor beta receptor signaling pathway 0.00737247915329922 206 124 7 0.0564516129032258 0.0339805825242718
GO:BP GO:0099623 regulation of cardiac muscle cell membrane repolarization 0.00764382349317145 29 102 3 0.0294117647058824 0.103448275862069
GO:BP GO:0010718 positive regulation of epithelial to mesenchymal transition 0.00854166855873781 51 60 3 0.05 0.0588235294117647
GO:BP GO:0031175 neuron projection development 0.00901177503332401 1012 36 8 0.222222222222222 0.00790513833992095
GO:BP GO:0051128 regulation of cellular component organization 0.00927965220774442 2412 113 28 0.247787610619469 0.0116086235489221
GO:BP GO:0030336 negative regulation of cell migration 0.00943580391104159 353 124 9 0.0725806451612903 0.0254957507082153
GO:BP GO:0051261 protein depolymerization 0.0100170742245102 117 64 4 0.0625 0.0341880341880342
GO:BP GO:0048523 negative regulation of cellular process 0.0101842346784901 5139 124 52 0.419354838709677 0.0101187001362133
GO:BP GO:0001649 osteoblast differentiation 0.0102087644644744 232 33 4 0.121212121212121 0.0172413793103448
GO:BP GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 0.0102805535230149 41 81 3 0.037037037037037 0.0731707317073171
GO:BP GO:0044085 cellular component biogenesis 0.0103844573579298 3257 107 33 0.308411214953271 0.0101320233343568
GO:BP GO:0006469 negative regulation of protein kinase activity 0.0112100525667787 251 81 6 0.0740740740740741 0.0239043824701195
GO:BP GO:0086001 cardiac muscle cell action potential 0.0114940294610748 77 102 4 0.0392156862745098 0.051948051948052
GO:BP GO:0010634 positive regulation of epithelial cell migration 0.0116445637936855 181 113 6 0.0530973451327434 0.0331491712707182
GO:BP GO:0086010 membrane depolarization during action potential 0.0118566564503588 35 102 3 0.0294117647058824 0.0857142857142857
GO:BP GO:2000146 negative regulation of cell motility 0.0118566564503588 369 124 9 0.0725806451612903 0.024390243902439
GO:BP GO:0045785 positive regulation of cell adhesion 0.012121252467361 437 85 8 0.0941176470588235 0.0183066361556064
GO:BP GO:0090505 epiboly involved in wound healing 0.0123421401480816 34 107 3 0.0280373831775701 0.0882352941176471
GO:BP GO:0044319 wound healing, spreading of cells 0.0123421401480816 34 107 3 0.0280373831775701 0.0882352941176471
GO:BP GO:0030834 regulation of actin filament depolymerization 0.012525261395364 57 64 3 0.046875 0.0526315789473684
GO:BP GO:0090504 epiboly 0.0132156696313176 35 107 3 0.0280373831775701 0.0857142857142857
GO:BP GO:0060306 regulation of membrane repolarization 0.0134379792277635 37 102 3 0.0294117647058824 0.0810810810810811
GO:BP GO:0045055 regulated exocytosis 0.0134838931721638 785 61 9 0.147540983606557 0.0114649681528662
GO:BP GO:0031529 ruffle organization 0.0137196497470182 56 68 3 0.0441176470588235 0.0535714285714286
GO:BP GO:0061041 regulation of wound healing 0.0142202656485533 136 107 5 0.0467289719626168 0.0367647058823529
GO:BP GO:0043270 positive regulation of ion transport 0.0144664681886722 694 113 12 0.106194690265487 0.0172910662824208
GO:BP GO:0010761 fibroblast migration 0.0147757148285369 52 76 3 0.0394736842105263 0.0576923076923077
GO:BP GO:0060048 cardiac muscle contraction 0.0147757148285369 139 106 5 0.0471698113207547 0.0359712230215827
GO:BP GO:0045987 positive regulation of smooth muscle contraction 0.0148518213281143 31 129 3 0.0232558139534884 0.0967741935483871
GO:BP GO:0099622 cardiac muscle cell membrane repolarization 0.0148518213281143 39 102 3 0.0294117647058824 0.0769230769230769
GO:BP GO:0051348 negative regulation of transferase activity 0.0148956704079096 310 97 7 0.0721649484536082 0.0225806451612903
GO:BP GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 0.0148984179228686 129 115 5 0.0434782608695652 0.0387596899224806
GO:BP GO:0033673 negative regulation of kinase activity 0.0154814342269144 275 81 6 0.0740740740740741 0.0218181818181818
GO:BP GO:0071363 cellular response to growth factor stimulus 0.0159610955486228 731 124 13 0.104838709677419 0.0177838577291382
GO:BP GO:0048660 regulation of smooth muscle cell proliferation 0.0160248897161826 174 24 3 0.125 0.0172413793103448
GO:BP GO:0001954 positive regulation of cell-matrix adhesion 0.0160566058257596 55 75 3 0.04 0.0545454545454545
GO:BP GO:0051492 regulation of stress fiber assembly 0.0160566058257596 94 44 3 0.0681818181818182 0.0319148936170213
GO:BP GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 0.0160566058257596 132 115 5 0.0434782608695652 0.0378787878787879
GO:BP GO:0048666 neuron development 0.0162471259654149 1149 36 8 0.222222222222222 0.00696257615317668
GO:BP GO:0048659 smooth muscle cell proliferation 0.0162471259654149 176 24 3 0.125 0.0170454545454545
GO:BP GO:0045661 regulation of myoblast differentiation 0.0166928736825329 52 81 3 0.037037037037037 0.0576923076923077
GO:BP GO:0006887 exocytosis 0.0167330582453765 904 78 11 0.141025641025641 0.0121681415929204
GO:BP GO:0003007 heart morphogenesis 0.017434857948984 251 124 7 0.0564516129032258 0.0278884462151394
GO:BP GO:0040013 negative regulation of locomotion 0.0178044033223796 401 124 9 0.0725806451612903 0.0224438902743142
GO:BP GO:0051653 spindle localization 0.0181460914734225 56 78 3 0.0384615384615385 0.0535714285714286
GO:BP GO:1901381 positive regulation of potassium ion transmembrane transport 0.018177370119106 43 102 3 0.0294117647058824 0.0697674418604651
GO:BP GO:0048518 positive regulation of biological process 0.0182568864506516 6363 115 56 0.48695652173913 0.0088008800880088
GO:BP GO:0008038 neuron recognition 0.018477758440837 47 94 3 0.0319148936170213 0.0638297872340425
GO:BP GO:0048844 artery morphogenesis 0.018653176287172 77 124 4 0.032258064516129 0.051948051948052
GO:BP GO:0051094 positive regulation of developmental process 0.018653176287172 1341 124 19 0.153225806451613 0.0141685309470544
GO:BP GO:0071560 cellular response to transforming growth factor beta stimulus 0.018653176287172 256 124 7 0.0564516129032258 0.02734375
GO:BP GO:0060284 regulation of cell development 0.0190600542600167 502 33 5 0.151515151515152 0.0099601593625498
GO:BP GO:0061351 neural precursor cell proliferation 0.0190818226221845 148 109 5 0.0458715596330275 0.0337837837837838
GO:BP GO:0110020 regulation of actomyosin structure organization 0.0192088938339254 104 44 3 0.0681818181818182 0.0288461538461538
GO:BP GO:0032781 positive regulation of ATPase activity 0.0192088938339254 57 80 3 0.0375 0.0526315789473684
GO:BP GO:0044087 regulation of cellular component biogenesis 0.0192088938339254 990 107 14 0.130841121495327 0.0141414141414141
GO:BP GO:1901379 regulation of potassium ion transmembrane transport 0.0192088938339254 95 102 4 0.0392156862745098 0.0421052631578947
GO:BP GO:0031532 actin cytoskeleton reorganization 0.019451729734377 106 92 4 0.0434782608695652 0.0377358490566038
GO:BP GO:0070848 response to growth factor 0.0195305445543406 759 124 13 0.104838709677419 0.0171277997364954
GO:BP GO:0070887 cellular response to chemical stimulus 0.019557288119582 3393 125 37 0.296 0.0109048040082523
GO:BP GO:0071559 response to transforming growth factor beta 0.0201352768655704 262 124 7 0.0564516129032258 0.0267175572519084
GO:BP GO:1901888 regulation of cell junction assembly 0.0201352768655704 202 119 6 0.0504201680672269 0.0297029702970297
GO:BP GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 0.020601594428173 43 110 3 0.0272727272727273 0.0697674418604651
GO:BP GO:0035295 tube development 0.0208432541770246 1146 94 14 0.148936170212766 0.012216404886562
GO:BP GO:0044089 positive regulation of cellular component biogenesis 0.0210870933339454 540 46 6 0.130434782608696 0.0111111111111111
GO:BP GO:0003254 regulation of membrane depolarization 0.021628208799766 46 105 3 0.0285714285714286 0.0652173913043478
GO:BP GO:0050808 synapse organization 0.021628208799766 428 40 5 0.125 0.0116822429906542
GO:BP GO:0009967 positive regulation of signal transduction 0.0220675593309539 1598 115 20 0.173913043478261 0.0125156445556946
GO:BP GO:0086009 membrane repolarization 0.0222883505005887 48 102 3 0.0294117647058824 0.0625
GO:BP GO:0016192 vesicle-mediated transport 0.0224943716050673 2180 80 19 0.2375 0.00871559633027523
GO:BP GO:0014910 regulation of smooth muscle cell migration 0.0237544973117271 85 124 4 0.032258064516129 0.0470588235294118
GO:BP GO:0033059 cellular pigmentation 0.0243051467951985 52 99 3 0.0303030303030303 0.0576923076923077
GO:BP GO:0048584 positive regulation of response to stimulus 0.0243051467951985 2344 115 26 0.226086956521739 0.0110921501706485
GO:BP GO:0098662 inorganic cation transmembrane transport 0.0243051467951985 794 123 13 0.105691056910569 0.0163727959697733
GO:BP GO:0045595 regulation of cell differentiation 0.0243051467951985 1679 22 7 0.318181818181818 0.00416914830256105
GO:BP GO:0031647 regulation of protein stability 0.0254623194130223 300 115 7 0.0608695652173913 0.0233333333333333
GO:BP GO:0010632 regulation of epithelial cell migration 0.0256742487520247 306 113 7 0.0619469026548673 0.0228758169934641
GO:BP GO:1904705 regulation of vascular associated smooth muscle cell proliferation 0.0259292923931231 88 124 4 0.032258064516129 0.0454545454545455
GO:BP GO:1990874 vascular associated smooth muscle cell proliferation 0.0259292923931231 88 124 4 0.032258064516129 0.0454545454545455
GO:BP GO:0010717 regulation of epithelial to mesenchymal transition 0.0259292923931231 102 107 4 0.0373831775700935 0.0392156862745098
GO:BP GO:0035088 establishment or maintenance of apical/basal cell polarity 0.0269089810855275 49 110 3 0.0272727272727273 0.0612244897959184
GO:BP GO:0061245 establishment or maintenance of bipolar cell polarity 0.0269089810855275 49 110 3 0.0272727272727273 0.0612244897959184
GO:BP GO:0045936 negative regulation of phosphate metabolic process 0.0269089810855275 543 120 10 0.0833333333333333 0.0184162062615101
GO:BP GO:0008285 negative regulation of cell population proliferation 0.0269096083347011 790 24 5 0.208333333333333 0.00632911392405063
GO:BP GO:0010563 negative regulation of phosphorus metabolic process 0.0269415917998097 544 120 10 0.0833333333333333 0.0183823529411765
GO:BP GO:0043266 regulation of potassium ion transport 0.0278028727384534 110 102 4 0.0392156862745098 0.0363636363636364
GO:BP GO:0030833 regulation of actin filament polymerization 0.0284086818472416 177 104 5 0.0480769230769231 0.0282485875706215
GO:BP GO:0051130 positive regulation of cellular component organization 0.0284579538059891 1153 68 11 0.161764705882353 0.00954032957502168
GO:BP GO:0022898 regulation of transmembrane transporter activity 0.0286293891041449 281 95 6 0.0631578947368421 0.0213523131672598
GO:BP GO:0050821 protein stabilization 0.029850267571931 193 97 5 0.0515463917525773 0.0259067357512953
GO:BP GO:1901879 regulation of protein depolymerization 0.0304354136112231 90 64 3 0.046875 0.0333333333333333
GO:BP GO:0033002 muscle cell proliferation 0.0304354136112231 244 24 3 0.125 0.0122950819672131
GO:BP GO:0045933 positive regulation of muscle contraction 0.0306832418963748 45 129 3 0.0232558139534884 0.0666666666666667
GO:BP GO:0006941 striated muscle contraction 0.0314529789023024 180 106 5 0.0471698113207547 0.0277777777777778
GO:BP GO:0048738 cardiac muscle tissue development 0.0333750146962112 224 124 6 0.0483870967741935 0.0267857142857143
GO:BP GO:0022008 neurogenesis 0.0338051792061802 1675 36 9 0.25 0.00537313432835821
GO:BP GO:0014706 striated muscle tissue development 0.0339148856031834 380 124 8 0.0645161290322581 0.0210526315789474
GO:BP GO:0032409 regulation of transporter activity 0.0345171357288781 297 95 6 0.0631578947368421 0.0202020202020202
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0345391352721615 3210 115 32 0.278260869565217 0.00996884735202492
GO:BP GO:0065009 regulation of molecular function 0.0347807802864405 3221 97 28 0.288659793814433 0.00869295249922384
GO:BP GO:0043086 negative regulation of catalytic activity 0.0347807802864405 851 122 13 0.10655737704918 0.0152761457109283
GO:BP GO:0002011 morphogenesis of an epithelial sheet 0.0350961358656983 58 107 3 0.0280373831775701 0.0517241379310345
GO:BP GO:0051050 positive regulation of transport 0.0352690568162512 923 113 13 0.115044247787611 0.0140845070422535
GO:BP GO:0051239 regulation of multicellular organismal process 0.0352690568162512 2861 94 25 0.265957446808511 0.00873820342537574
GO:BP GO:0071310 cellular response to organic substance 0.0362663374091875 2776 92 24 0.260869565217391 0.00864553314121038
GO:BP GO:0051235 maintenance of location 0.0363563370357351 337 113 7 0.0619469026548673 0.0207715133531157
GO:BP GO:0060840 artery development 0.0367674416672176 102 124 4 0.032258064516129 0.0392156862745098
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 0.0367674416672176 503 41 5 0.121951219512195 0.0099403578528827
GO:BP GO:0048522 positive regulation of cellular process 0.0372723097906013 5757 115 50 0.434782608695652 0.00868507903421921
GO:BP GO:0030041 actin filament polymerization 0.0374706898927716 196 104 5 0.0480769230769231 0.0255102040816327
GO:BP GO:0065007 biological regulation 0.0377085026397132 12809 97 80 0.824742268041237 0.00624560855648372
GO:BP GO:0030182 neuron differentiation 0.0378969394977757 1412 22 6 0.272727272727273 0.00424929178470255
GO:BP GO:0009615 response to virus 0.0384512137816759 364 36 4 0.111111111111111 0.010989010989011
GO:BP GO:0002028 regulation of sodium ion transport 0.0392232833140948 87 76 3 0.0394736842105263 0.0344827586206897
GO:BP GO:0030838 positive regulation of actin filament polymerization 0.0394527008261797 104 64 3 0.046875 0.0288461538461538
GO:BP GO:0001738 morphogenesis of a polarized epithelium 0.039455055849385 152 44 3 0.0681818181818182 0.0197368421052632
GO:BP GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0412412653450204 136 50 3 0.06 0.0220588235294118
GO:BP GO:0045445 myoblast differentiation 0.0414579067576837 84 81 3 0.037037037037037 0.0357142857142857
GO:BP GO:0006909 phagocytosis 0.0420635580033419 387 78 6 0.0769230769230769 0.0155038759689922
GO:BP GO:0001933 negative regulation of protein phosphorylation 0.0422754404178884 373 81 6 0.0740740740740741 0.0160857908847185
GO:BP GO:0001503 ossification 0.0428241681594888 417 33 4 0.121212121212121 0.00959232613908873
GO:BP GO:0042306 regulation of protein import into nucleus 0.0428241681594888 62 113 3 0.0265486725663717 0.0483870967741935
GO:BP GO:0010959 regulation of metal ion transport 0.0428241681594888 268 113 6 0.0530973451327434 0.0223880597014925
GO:BP GO:0060047 heart contraction 0.0430387793052864 288 106 6 0.0566037735849057 0.0208333333333333
GO:BP GO:0098660 inorganic ion transmembrane transport 0.0432209128411469 883 123 13 0.105691056910569 0.014722536806342
GO:BP GO:0030837 negative regulation of actin filament polymerization 0.0433864635641525 68 104 3 0.0288461538461538 0.0441176470588235
GO:BP GO:0010647 positive regulation of cell communication 0.0437487222201091 1777 129 22 0.170542635658915 0.0123804164321891
GO:BP GO:0051336 regulation of hydrolase activity 0.044765999640221 1321 122 17 0.139344262295082 0.0128690386071158
GO:BP GO:0001894 tissue homeostasis 0.044765999640221 270 27 3 0.111111111111111 0.0111111111111111
GO:BP GO:0023056 positive regulation of signaling 0.044765999640221 1782 129 22 0.170542635658915 0.0123456790123457
GO:BP GO:0001508 action potential 0.0453442734779447 137 102 4 0.0392156862745098 0.0291970802919708
GO:BP GO:0051283 negative regulation of sequestering of calcium ion 0.0455729432263065 124 113 4 0.0353982300884956 0.032258064516129
GO:BP GO:0055008 cardiac muscle tissue morphogenesis 0.0460691625197372 59 124 3 0.0241935483870968 0.0508474576271186
GO:BP GO:1904589 regulation of protein import 0.0465493406226112 65 113 3 0.0265486725663717 0.0461538461538462
GO:BP GO:0010812 negative regulation of cell-substrate adhesion 0.0466858605145201 69 107 3 0.0280373831775701 0.0434782608695652
GO:BP GO:0001568 blood vessel development 0.0466858605145201 792 94 10 0.106382978723404 0.0126262626262626
GO:BP GO:0051282 regulation of sequestering of calcium ion 0.0469673702017902 126 113 4 0.0353982300884956 0.0317460317460317
GO:BP GO:0003015 heart process 0.0475128757125707 298 106 6 0.0566037735849057 0.0201342281879195
GO:BP GO:0050789 regulation of biological process 0.0483067304582665 12091 97 76 0.783505154639175 0.00628566702505996
GO:BP GO:0043624 cellular protein complex disassembly 0.0483113926860437 226 64 4 0.0625 0.0176991150442478
GO:BP GO:0000086 G2/M transition of mitotic cell cycle 0.0484730962685008 265 86 5 0.0581395348837209 0.0188679245283019
GO:CC GO:0015629 actin cytoskeleton 1.52693045324156e-35 513 93 40 0.43010752688172 0.0779727095516569
GO:CC GO:0005925 focal adhesion 6.24389170595762e-32 420 78 33 0.423076923076923 0.0785714285714286
GO:CC GO:0030055 cell-substrate junction 7.21992461674161e-32 427 78 33 0.423076923076923 0.0772833723653396
GO:CC GO:0043292 contractile fiber 1.70686749602936e-30 240 95 29 0.305263157894737 0.120833333333333
GO:CC GO:0030016 myofibril 5.49211731903214e-28 231 106 28 0.264150943396226 0.121212121212121
GO:CC GO:0070161 anchoring junction 9.36635039769698e-28 836 78 37 0.474358974358974 0.0442583732057416
GO:CC GO:0005856 cytoskeleton 1.00619569853933e-26 2332 110 62 0.563636363636364 0.0265866209262436
GO:CC GO:0032432 actin filament bundle 1.14177974903071e-26 76 89 19 0.213483146067416 0.25
GO:CC GO:0030017 sarcomere 1.85029072507282e-26 208 106 26 0.245283018867925 0.125
GO:CC GO:0099512 supramolecular fiber 5.56866823339373e-26 993 106 43 0.405660377358491 0.0433031218529708
GO:CC GO:0099081 supramolecular polymer 7.00750883078737e-26 1001 106 43 0.405660377358491 0.042957042957043
GO:CC GO:0097517 contractile actin filament bundle 5.89666610738262e-24 68 89 17 0.191011235955056 0.25
GO:CC GO:0001725 stress fiber 5.89666610738262e-24 68 89 17 0.191011235955056 0.25
GO:CC GO:0042641 actomyosin 5.78447505453525e-23 77 89 17 0.191011235955056 0.220779220779221
GO:CC GO:0099080 supramolecular complex 3.34220903016156e-22 1323 101 43 0.425742574257426 0.0325018896447468
GO:CC GO:0031674 I band 1.39817795211189e-21 139 106 20 0.188679245283019 0.143884892086331
GO:CC GO:0030018 Z disc 3.09363287524445e-20 126 95 18 0.189473684210526 0.142857142857143
GO:CC GO:0030054 cell junction 4.34772692305643e-18 2105 78 41 0.525641025641026 0.0194774346793349
GO:CC GO:0005884 actin filament 2.76406853292399e-15 118 106 15 0.141509433962264 0.127118644067797
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 1.96022828331881e-13 5338 97 64 0.65979381443299 0.011989509179468
GO:CC GO:0043228 non-membrane-bounded organelle 2.01733902657048e-13 5346 97 64 0.65979381443299 0.0119715675271231
GO:CC GO:0031252 cell leading edge 1.42118246499483e-12 422 78 18 0.230769230769231 0.042654028436019
GO:CC GO:0030027 lamellipodium 2.92779562091879e-10 200 74 12 0.162162162162162 0.06
GO:CC GO:0005911 cell-cell junction 4.49014258651517e-10 494 93 18 0.193548387096774 0.0364372469635627
GO:CC GO:0005938 cell cortex 1.04589903708986e-08 311 115 15 0.130434782608696 0.0482315112540193
GO:CC GO:0005829 cytosol 1.2890093379748e-08 5303 48 34 0.708333333333333 0.00641146520837262
GO:CC GO:0099513 polymeric cytoskeletal fiber 1.81480437449918e-08 764 106 21 0.19811320754717 0.0274869109947644
GO:CC GO:0005862 muscle thin filament tropomyosin 2.28236442913437e-08 4 15 3 0.2 0.75
GO:CC GO:0005912 adherens junction 1.78329314154354e-07 173 93 10 0.10752688172043 0.0578034682080925
GO:CC GO:0005737 cytoplasm 2.54561969324892e-07 11911 95 84 0.884210526315789 0.00705230459239359
GO:CC GO:0070062 extracellular exosome 3.71158673394776e-07 2176 80 28 0.35 0.0128676470588235
GO:CC GO:0001726 ruffle 6.32926177745787e-07 179 78 9 0.115384615384615 0.0502793296089385
GO:CC GO:0030863 cortical cytoskeleton 6.53539319584623e-07 107 93 8 0.0860215053763441 0.0747663551401869
GO:CC GO:0043230 extracellular organelle 7.66881658626634e-07 2263 80 28 0.35 0.0123729562527618
GO:CC GO:1903561 extracellular vesicle 7.66881658626634e-07 2261 80 28 0.35 0.0123839009287926
GO:CC GO:0043229 intracellular organelle 1.14825284450855e-06 12491 70 65 0.928571428571429 0.00520374669762229
GO:CC GO:0042995 cell projection 2.18395920104479e-06 2330 47 20 0.425531914893617 0.00858369098712446
GO:CC GO:0120025 plasma membrane bounded cell projection 5.59382434530523e-06 2229 47 19 0.404255319148936 0.00852400179452669
GO:CC GO:0005865 striated muscle thin filament 7.18982180115974e-06 23 15 3 0.2 0.130434782608696
GO:CC GO:0036379 myofilament 1.15559307261514e-05 27 15 3 0.2 0.111111111111111
GO:CC GO:0030864 cortical actin cytoskeleton 2.39943776848112e-05 79 93 6 0.0645161290322581 0.0759493670886076
GO:CC GO:0005903 brush border 3.77501691259635e-05 107 115 7 0.0608695652173913 0.0654205607476635
GO:CC GO:0005916 fascia adherens 3.82894349030401e-05 10 63 3 0.0476190476190476 0.3
GO:CC GO:0031982 vesicle 5.32898355400344e-05 4055 80 35 0.4375 0.00863131935881628
GO:CC GO:0071944 cell periphery 5.36376381900169e-05 6169 116 61 0.525862068965517 0.00988815042956719
GO:CC GO:0043226 organelle 0.000100614153268723 14008 89 82 0.921348314606742 0.00585379782981154
GO:CC GO:0002102 podosome 0.000152034738877194 28 35 3 0.0857142857142857 0.107142857142857
GO:CC GO:0031941 filamentous actin 0.000153802425546147 33 30 3 0.1 0.0909090909090909
GO:CC GO:0032587 ruffle membrane 0.000193658983163574 96 68 5 0.0735294117647059 0.0520833333333333
GO:CC GO:0005886 plasma membrane 0.000225375998367916 5681 96 48 0.5 0.00844921668720296
GO:CC GO:0005615 extracellular space 0.000225375998367916 3594 80 31 0.3875 0.00862548692264886
GO:CC GO:0005622 intracellular anatomical structure 0.000231715954418927 14790 95 89 0.936842105263158 0.00601757944557133
GO:CC GO:0098862 cluster of actin-based cell projections 0.00024617330476058 162 22 4 0.181818181818182 0.0246913580246914
GO:CC GO:0031256 leading edge membrane 0.00028050528573385 175 68 6 0.0882352941176471 0.0342857142857143
GO:CC GO:0014704 intercalated disc 0.000397386817742749 52 76 4 0.0526315789473684 0.0769230769230769
GO:CC GO:0016459 myosin complex 0.000438690644268668 57 26 3 0.115384615384615 0.0526315789473684
GO:CC GO:0043198 dendritic shaft 0.000440409970918412 36 115 4 0.0347826086956522 0.111111111111111
GO:CC GO:0005576 extracellular region 0.000759348479083181 4567 63 29 0.46031746031746 0.0063499014670462
GO:CC GO:0044291 cell-cell contact zone 0.00139893386903066 74 76 4 0.0526315789473684 0.0540540540540541
GO:CC GO:0031253 cell projection membrane 0.00139893386903066 343 68 7 0.102941176470588 0.0204081632653061
GO:CC GO:0042383 sarcolemma 0.00152142186488582 140 76 5 0.0657894736842105 0.0357142857142857
GO:CC GO:0030424 axon 0.00362344249073171 660 31 6 0.193548387096774 0.00909090909090909
GO:CC GO:0032991 protein-containing complex 0.00485257694954432 5548 22 14 0.636363636363636 0.00252343186733958
GO:CC GO:0016020 membrane 0.00572872189619518 9838 99 67 0.676767676767677 0.00681032730229721
GO:CC GO:0072562 blood microparticle 0.00617299578059055 140 106 5 0.0471698113207547 0.0357142857142857
GO:CC GO:0098978 glutamatergic synapse 0.00631231145754637 349 12 3 0.25 0.00859598853868195
GO:CC GO:0015630 microtubule cytoskeleton 0.00716012755898554 1307 110 17 0.154545454545455 0.0130068859984698
GO:CC GO:0150034 distal axon 0.00758235582804004 308 31 4 0.129032258064516 0.012987012987013
GO:CC GO:0016363 nuclear matrix 0.00883300834764175 110 89 4 0.0449438202247191 0.0363636363636364
GO:CC GO:0048770 pigment granule 0.010364345018174 105 99 4 0.0404040404040404 0.0380952380952381
GO:CC GO:0042470 melanosome 0.010364345018174 105 99 4 0.0404040404040404 0.0380952380952381
GO:CC GO:0044297 cell body 0.0131286254382318 592 20 4 0.2 0.00675675675675676
GO:CC GO:0045202 synapse 0.0136210010356242 1349 78 13 0.166666666666667 0.00963676797627873
GO:CC GO:0031594 neuromuscular junction 0.0139340037610688 73 78 3 0.0384615384615385 0.0410958904109589
GO:CC GO:0034399 nuclear periphery 0.0141332813449574 132 89 4 0.0449438202247191 0.0303030303030303
GO:CC GO:0034774 secretory granule lumen 0.0144549287655536 320 61 5 0.0819672131147541 0.015625
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0150412775868195 324 61 5 0.0819672131147541 0.0154320987654321
GO:CC GO:0031983 vesicle lumen 0.0152888715985323 326 61 5 0.0819672131147541 0.0153374233128834
GO:CC GO:0043296 apical junction complex 0.0209191634930506 145 93 4 0.043010752688172 0.0275862068965517
GO:CC GO:0043005 neuron projection 0.0215866728254454 1380 31 7 0.225806451612903 0.00507246376811594
GO:CC GO:0062023 collagen-containing extracellular matrix 0.0261958864332095 421 101 7 0.0693069306930693 0.0166270783847981
GO:CC GO:0098590 plasma membrane region 0.0368054516074592 1240 130 16 0.123076923076923 0.0129032258064516
GO:CC GO:0043227 membrane-bounded organelle 0.0408699500920821 12858 87 69 0.793103448275862 0.00536630891273915
GO:CC GO:0005905 clathrin-coated pit 0.0422961136925663 71 130 3 0.0230769230769231 0.0422535211267606
GO:MF GO:0003779 actin binding 3.05627731319791e-33 448 115 40 0.347826086956522 0.0892857142857143
GO:MF GO:0008092 cytoskeletal protein binding 7.90024749064448e-30 996 115 49 0.426086956521739 0.0491967871485944
GO:MF GO:0051015 actin filament binding 3.40309013150161e-18 212 93 20 0.21505376344086 0.0943396226415094
GO:MF GO:0008307 structural constituent of muscle 2.1763614815225e-13 43 30 8 0.266666666666667 0.186046511627907
GO:MF GO:0044877 protein-containing complex binding 3.07022977577122e-09 1287 36 17 0.472222222222222 0.0132090132090132
GO:MF GO:0005198 structural molecule activity 1.0491655325982e-08 698 49 15 0.306122448979592 0.0214899713467049
GO:MF GO:0050839 cell adhesion molecule binding 5.20663991317213e-08 546 115 19 0.165217391304348 0.0347985347985348
GO:MF GO:0042805 actinin binding 9.18943877520138e-07 38 41 5 0.121951219512195 0.131578947368421
GO:MF GO:0051371 muscle alpha-actinin binding 1.16164255178295e-06 15 41 4 0.0975609756097561 0.266666666666667
GO:MF GO:0051393 alpha-actinin binding 1.53621638110701e-05 28 41 4 0.0975609756097561 0.142857142857143
GO:MF GO:0045296 cadherin binding 3.58269037178603e-05 333 115 12 0.104347826086957 0.036036036036036
GO:MF GO:0005200 structural constituent of cytoskeleton 4.40193016643138e-05 104 63 6 0.0952380952380952 0.0576923076923077
GO:MF GO:0042803 protein homodimerization activity 6.42861245337757e-05 676 110 16 0.145454545454545 0.0236686390532544
GO:MF GO:0005178 integrin binding 0.000133524083616593 147 85 7 0.0823529411764706 0.0476190476190476
GO:MF GO:0042802 identical protein binding 0.000641232358877762 2067 124 30 0.241935483870968 0.0145137880986938
GO:MF GO:0019904 protein domain specific binding 0.000696509835535761 710 115 15 0.130434782608696 0.0211267605633803
GO:MF GO:0005515 protein binding 0.00112685204607808 14767 97 91 0.938144329896907 0.00616238911085529
GO:MF GO:0044325 ion channel binding 0.00143452897199142 135 97 6 0.0618556701030928 0.0444444444444444
GO:MF GO:0005509 calcium ion binding 0.00171065973252789 721 29 7 0.241379310344828 0.00970873786407767
GO:MF GO:0046332 SMAD binding 0.00289173425782503 78 124 5 0.0403225806451613 0.0641025641025641
GO:MF GO:0005516 calmodulin binding 0.00342573887909954 204 78 6 0.0769230769230769 0.0294117647058824
GO:MF GO:0001786 phosphatidylserine binding 0.00360062390802348 59 95 4 0.0421052631578947 0.0677966101694915
GO:MF GO:0046983 protein dimerization activity 0.0036509913033958 1069 124 18 0.145161290322581 0.0168381665107577
GO:MF GO:0004675 transmembrane receptor protein serine/threonine kinase activity 0.00369955182182793 19 124 3 0.0241935483870968 0.157894736842105
GO:MF GO:0043167 ion binding 0.00398390449652127 6057 21 15 0.714285714285714 0.00247647350173353
GO:MF GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 0.00871156826063446 281 27 4 0.148148148148148 0.0142348754448399
GO:MF GO:0019901 protein kinase binding 0.0122004211384246 673 33 6 0.181818181818182 0.00891530460624071
GO:MF GO:0017022 myosin binding 0.0122004211384246 72 115 4 0.0347826086956522 0.0555555555555556
GO:MF GO:0050699 WW domain binding 0.0122004211384246 33 111 3 0.027027027027027 0.0909090909090909
GO:MF GO:0072341 modified amino acid binding 0.0133429219663492 91 95 4 0.0421052631578947 0.043956043956044
GO:MF GO:0003712 transcription coregulator activity 0.0152387340164683 506 81 8 0.0987654320987654 0.0158102766798419
GO:MF GO:0048156 tau protein binding 0.015651405358168 45 97 3 0.0309278350515464 0.0666666666666667
GO:MF GO:0019900 kinase binding 0.0165413189798711 752 33 6 0.181818181818182 0.00797872340425532
GO:MF GO:0140297 DNA-binding transcription factor binding 0.0196516079605707 391 27 4 0.148148148148148 0.010230179028133
GO:MF GO:0008134 transcription factor binding 0.0208639721935806 676 27 5 0.185185185185185 0.00739644970414201
GO:MF GO:0003713 transcription coactivator activity 0.0210280530170946 280 19 3 0.157894736842105 0.0107142857142857
GO:MF GO:0046982 protein heterodimerization activity 0.0210280530170946 357 15 3 0.2 0.00840336134453781
GO:MF GO:0046872 metal ion binding 0.0220274095696129 4260 21 11 0.523809523809524 0.00258215962441315
GO:MF GO:0043169 cation binding 0.024896530806678 4351 21 11 0.523809523809524 0.0025281544472535
GO:MF GO:0005524 ATP binding 0.0257784009458717 1501 9 4 0.444444444444444 0.00266489007328448
GO:MF GO:0032559 adenyl ribonucleotide binding 0.027609203281427 1565 9 4 0.444444444444444 0.00255591054313099
GO:MF GO:0030554 adenyl nucleotide binding 0.028003334856573 1578 9 4 0.444444444444444 0.00253485424588086
GO:MF GO:0031625 ubiquitin protein ligase binding 0.0364751427087671 296 105 6 0.0571428571428571 0.0202702702702703
GO:MF GO:0035639 purine ribonucleoside triphosphate binding 0.0394448442037287 1847 9 4 0.444444444444444 0.00216567406605306
GO:MF GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 0.0394448442037287 80 95 3 0.0315789473684211 0.0375
GO:MF GO:0044389 ubiquitin-like protein ligase binding 0.0415712678347916 314 105 6 0.0571428571428571 0.0191082802547771
GO:MF GO:0032555 purine ribonucleotide binding 0.0418112185186472 1918 9 4 0.444444444444444 0.00208550573514077
GO:MF GO:0032553 ribonucleotide binding 0.0418112185186472 1935 9 4 0.444444444444444 0.0020671834625323
GO:MF GO:0017076 purine nucleotide binding 0.0418112185186472 1933 9 4 0.444444444444444 0.00206932229694775
GO:MF GO:0035091 phosphatidylinositol binding 0.0421646248557068 255 95 5 0.0526315789473684 0.0196078431372549
GO:MF GO:0019899 enzyme binding 0.0455903642858496 2074 105 20 0.19047619047619 0.00964320154291225
GO:MF GO:1901981 phosphatidylinositol phosphate binding 0.0469514340818825 172 95 4 0.0421052631578947 0.0232558139534884
HP HP:0030914 Abnormal peristalsis 6.91315566379607e-05 20 9 4 0.444444444444444 0.2
HP HP:0002579 Gastrointestinal dysmotility 0.000403773446639204 71 12 5 0.416666666666667 0.0704225352112676
HP HP:0030895 Abnormal gastrointestinal motility 0.000403773446639204 71 12 5 0.416666666666667 0.0704225352112676
HP HP:0100771 Hypoperistalsis 0.00217462607356102 18 9 3 0.333333333333333 0.166666666666667
HP HP:0005245 Intestinal hypoplasia 0.00377415467238859 17 12 3 0.25 0.176470588235294
HP HP:0100578 Lipoatrophy 0.00535665951185839 70 22 5 0.227272727272727 0.0714285714285714
HP HP:0000072 Hydroureter 0.00535665951185839 66 12 4 0.333333333333333 0.0606060606060606
HP HP:0010955 Dilatation of the bladder 0.0071570722581336 11 81 4 0.0493827160493827 0.363636363636364
HP HP:0031567 Abnormal aortic valve cusp morphology 0.00825715375198858 86 12 4 0.333333333333333 0.0465116279069767
HP HP:0001647 Bicuspid aortic valve 0.00825715375198858 85 12 4 0.333333333333333 0.0470588235294118
HP HP:0002326 Transient ischemic attack 0.0107772791657888 55 9 3 0.333333333333333 0.0545454545454545
HP HP:0002616 Aortic root aneurysm 0.0107772791657888 73 7 3 0.428571428571429 0.0410958904109589
HP HP:0009125 Lipodystrophy 0.0107772791657888 106 22 5 0.227272727272727 0.0471698113207547
HP HP:0001166 Arachnodactyly 0.0107772791657888 106 12 4 0.333333333333333 0.0377358490566038
HP HP:0001238 Slender finger 0.0144791893419937 124 12 4 0.333333333333333 0.032258064516129
HP HP:0025633 Abnormal ureter morphology 0.015385126039794 127 12 4 0.333333333333333 0.031496062992126
HP HP:0031652 Abnormal aortic valve physiology 0.0173008964191975 133 12 4 0.333333333333333 0.0300751879699248
HP HP:0002566 Intestinal malrotation 0.0173008964191975 134 12 4 0.333333333333333 0.0298507462686567
HP HP:0004942 Aortic aneurysm 0.0178444002858731 138 12 4 0.333333333333333 0.0289855072463768
HP HP:0012727 Thoracic aortic aneurysm 0.0178444002858731 99 7 3 0.428571428571429 0.0303030303030303
HP HP:0001297 Stroke 0.0178444002858731 138 12 4 0.333333333333333 0.0289855072463768
HP HP:0001646 Abnormal aortic valve morphology 0.0183751019974419 140 12 4 0.333333333333333 0.0285714285714286
HP HP:0001654 Abnormal heart valve morphology 0.0203717910011333 279 12 5 0.416666666666667 0.017921146953405
HP HP:0004389 Intestinal pseudo-obstruction 0.0203717910011333 23 31 3 0.0967741935483871 0.130434782608696
HP HP:0031653 Abnormal heart valve physiology 0.0248114524091932 295 12 5 0.416666666666667 0.0169491525423729
HP HP:0001539 Omphalocele 0.0280125312476285 72 12 3 0.25 0.0416666666666667
HP HP:0002637 Cerebral ischemia 0.0280125312476285 99 9 3 0.333333333333333 0.0303030303030303
HP HP:0033401 Tissue ischemia 0.0280125312476285 99 9 3 0.333333333333333 0.0303030303030303
HP HP:0001387 Joint stiffness 0.0299503469911791 175 12 4 0.333333333333333 0.0228571428571429
HP HP:0001659 Aortic regurgitation 0.0301173794330472 75 12 3 0.25 0.04
HP HP:0003557 Increased variability in muscle fiber diameter 0.0303208570631463 58 123 7 0.0569105691056911 0.120689655172414
HP HP:0002617 Vascular dilatation 0.0344707141296449 185 12 4 0.333333333333333 0.0216216216216216
HP HP:0000278 Retrognathia 0.0349145183659293 261 9 4 0.444444444444444 0.0153256704980843
HP HP:0012084 Abnormality of skeletal muscle fiber size 0.0384586978424092 61 123 7 0.0569105691056911 0.114754098360656
HP HP:0025323 Abnormal arterial physiology 0.0490620219348558 130 9 3 0.333333333333333 0.0230769230769231
HPA HPA:0490693 smooth muscle; smooth muscle cells[High] 6.83146600538421e-15 589 66 27 0.409090909090909 0.0458404074702886
HPA HPA:0490692 smooth muscle; smooth muscle cells[≥Medium] 2.4041929450531e-10 3038 69 48 0.695652173913043 0.0157998683344305
HPA HPA:0490691 smooth muscle; smooth muscle cells[≥Low] 1.82942013978261e-05 5324 31 29 0.935483870967742 0.00544703230653644
HPA HPA:0490000 smooth muscle 1.82942013978261e-05 5324 31 29 0.935483870967742 0.00544703230653644
HPA HPA:0050092 breast; myoepithelial cells[≥Medium] 0.00280260345275435 3700 29 21 0.724137931034483 0.00567567567567568
KEGG KEGG:04810 Regulation of actin cytoskeleton 1.79810612773592e-08 216 78 16 0.205128205128205 0.0740740740740741
KEGG KEGG:04510 Focal adhesion 1.79810612773592e-08 200 26 10 0.384615384615385 0.05
KEGG KEGG:04270 Vascular smooth muscle contraction 5.52932976650757e-06 133 16 6 0.375 0.0451127819548872
KEGG KEGG:05131 Shigellosis 2.17123967624406e-05 246 26 8 0.307692307692308 0.032520325203252
KEGG KEGG:04670 Leukocyte transendothelial migration 3.37156096415509e-05 114 26 6 0.230769230769231 0.0526315789473684
KEGG KEGG:04530 Tight junction 9.28329498568607e-05 169 46 8 0.173913043478261 0.0473372781065089
KEGG KEGG:05410 Hypertrophic cardiomyopathy 0.000334629847636011 90 15 4 0.266666666666667 0.0444444444444444
KEGG KEGG:05414 Dilated cardiomyopathy 0.000354637099437097 95 15 4 0.266666666666667 0.0421052631578947
KEGG KEGG:04921 Oxytocin signaling pathway 0.000354637099437097 154 10 4 0.4 0.025974025974026
KEGG KEGG:04520 Adherens junction 0.000465111060907735 71 22 4 0.181818181818182 0.0563380281690141
KEGG KEGG:05132 Salmonella infection 0.00296750683538955 249 84 10 0.119047619047619 0.0401606425702811
KEGG KEGG:05146 Amoebiasis 0.00352640801226903 101 27 4 0.148148148148148 0.0396039603960396
KEGG KEGG:04260 Cardiac muscle contraction 0.00498299304369895 87 15 3 0.2 0.0344827586206897
KEGG KEGG:04611 Platelet activation 0.00567828078788831 124 26 4 0.153846153846154 0.032258064516129
KEGG KEGG:05100 Bacterial invasion of epithelial cells 0.00800188529272363 77 46 4 0.0869565217391304 0.051948051948052
KEGG KEGG:04360 Axon guidance 0.0115424372731116 181 75 7 0.0933333333333333 0.0386740331491713
KEGG KEGG:04261 Adrenergic signaling in cardiomyocytes 0.018458696046073 150 15 3 0.2 0.02
MIRNA MIRNA:hsa-miR-1-3p hsa-miR-1-3p 0.0010222445796812 915 19 9 0.473684210526316 0.00983606557377049
MIRNA MIRNA:hsa-miR-124-3p hsa-miR-124-3p 0.00934342089459692 1442 130 29 0.223076923076923 0.0201109570041609
MIRNA MIRNA:hsa-miR-4684-3p hsa-miR-4684-3p 0.00934342089459692 52 15 3 0.2 0.0576923076923077
MIRNA MIRNA:hsa-let-7i-3p hsa-let-7i-3p 0.0101355220009742 10 98 3 0.0306122448979592 0.3
MIRNA MIRNA:hsa-miR-656-5p hsa-miR-656-5p 0.0101355220009742 29 31 3 0.0967741935483871 0.103448275862069
MIRNA MIRNA:hsa-miR-7111-5p hsa-miR-7111-5p 0.0134404104474348 257 102 9 0.0882352941176471 0.0350194552529183
MIRNA MIRNA:hsa-miR-6870-5p hsa-miR-6870-5p 0.0134404104474348 254 102 9 0.0882352941176471 0.0354330708661417
MIRNA MIRNA:hsa-miR-4723-5p hsa-miR-4723-5p 0.0134404104474348 252 102 9 0.0882352941176471 0.0357142857142857
MIRNA MIRNA:hsa-miR-4525 hsa-miR-4525 0.0137619321948672 152 102 7 0.0686274509803922 0.0460526315789474
MIRNA MIRNA:hsa-miR-5010-5p hsa-miR-5010-5p 0.0137619321948672 153 102 7 0.0686274509803922 0.0457516339869281
MIRNA MIRNA:hsa-miR-4665-5p hsa-miR-4665-5p 0.0157784475252929 161 102 7 0.0686274509803922 0.0434782608695652
MIRNA MIRNA:hsa-miR-1275 hsa-miR-1275 0.0157784475252929 160 102 7 0.0686274509803922 0.04375
MIRNA MIRNA:hsa-miR-324-5p hsa-miR-324-5p 0.0159235953556567 297 40 6 0.15 0.0202020202020202
MIRNA MIRNA:hsa-miR-6782-5p hsa-miR-6782-5p 0.019648472550598 95 44 4 0.0909090909090909 0.0421052631578947
MIRNA MIRNA:hsa-miR-6124 hsa-miR-6124 0.0216139448757146 181 99 7 0.0707070707070707 0.0386740331491713
MIRNA MIRNA:hsa-miR-222-3p hsa-miR-222-3p 0.0425978464522 393 25 5 0.2 0.0127226463104326
MIRNA MIRNA:hsa-miR-218-5p hsa-miR-218-5p 0.0431439090370449 814 35 8 0.228571428571429 0.00982800982800983
MIRNA MIRNA:hsa-miR-193b-3p hsa-miR-193b-3p 0.0431439090370449 847 99 15 0.151515151515152 0.0177095631641086
REAC REAC:R-HSA-445355 Smooth Muscle Contraction 3.37952306212953e-23 38 29 13 0.448275862068966 0.342105263157895
REAC REAC:R-HSA-397014 Muscle contraction 3.02503457985291e-13 205 29 13 0.448275862068966 0.0634146341463415
REAC REAC:R-HSA-446353 Cell-extracellular matrix interactions 1.40134010483816e-09 18 71 7 0.0985915492957746 0.388888888888889
REAC REAC:R-HSA-5627123 RHO GTPases activate PAKs 4.30260173941932e-07 21 12 4 0.333333333333333 0.19047619047619
REAC REAC:R-HSA-114608 Platelet degranulation 9.91370073351591e-07 125 56 9 0.160714285714286 0.072
REAC REAC:R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 1.16575677068222e-06 130 56 9 0.160714285714286 0.0692307692307692
REAC REAC:R-HSA-5627117 RHO GTPases Activate ROCKs 9.00566217794546e-06 19 78 5 0.0641025641025641 0.263157894736842
REAC REAC:R-HSA-195258 RHO GTPase Effectors 2.78411728384106e-05 283 90 13 0.144444444444444 0.0459363957597173
REAC REAC:R-HSA-1500931 Cell-Cell communication 4.40867460907611e-05 127 47 7 0.148936170212766 0.0551181102362205
REAC REAC:R-HSA-446728 Cell junction organization 6.58794999061598e-05 91 71 7 0.0985915492957746 0.0769230769230769
REAC REAC:R-HSA-2682334 EPH-Ephrin signaling 6.58794999061598e-05 90 46 6 0.130434782608696 0.0666666666666667
REAC REAC:R-HSA-373755 Semaphorin interactions 0.000176267235233275 64 78 6 0.0769230769230769 0.09375
REAC REAC:R-HSA-76002 Platelet activation, signaling and aggregation 0.000176267235233275 258 56 9 0.160714285714286 0.0348837209302326
REAC REAC:R-HSA-5625900 RHO GTPases activate CIT 0.000213038339279538 19 78 4 0.0512820512820513 0.210526315789474
REAC REAC:R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 0.000305303782654737 8 71 3 0.0422535211267606 0.375
REAC REAC:R-HSA-390522 Striated Muscle Contraction 0.000305303782654737 36 15 3 0.2 0.0833333333333333
REAC REAC:R-HSA-400685 Sema4D in semaphorin signaling 0.00046765341721668 24 78 4 0.0512820512820513 0.166666666666667
REAC REAC:R-HSA-422475 Axon guidance 0.000674130638851664 549 78 14 0.179487179487179 0.0255009107468124
REAC REAC:R-HSA-194315 Signaling by Rho GTPases 0.000674130638851664 413 90 13 0.144444444444444 0.0314769975786925
REAC REAC:R-HSA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 0.000674130638851664 413 90 13 0.144444444444444 0.0314769975786925
REAC REAC:R-HSA-9675108 Nervous system development 0.000996661998067702 574 78 14 0.179487179487179 0.024390243902439
REAC REAC:R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.00100656283070316 35 25 3 0.12 0.0857142857142857
REAC REAC:R-HSA-5674135 MAP2K and MAPK activation 0.0013359981268894 39 25 3 0.12 0.0769230769230769
REAC REAC:R-HSA-9656223 Signaling by RAF1 mutants 0.00138197770113843 40 25 3 0.12 0.075
REAC REAC:R-HSA-5625740 RHO GTPases activate PKNs 0.00147703127379956 58 90 5 0.0555555555555556 0.0862068965517241
REAC REAC:R-HSA-9649948 Signaling downstream of RAS mutants 0.00147703127379956 45 25 3 0.12 0.0666666666666667
REAC REAC:R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.00147703127379956 45 25 3 0.12 0.0666666666666667
REAC REAC:R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.00147703127379956 45 25 3 0.12 0.0666666666666667
REAC REAC:R-HSA-109582 Hemostasis 0.00147703127379956 657 56 12 0.214285714285714 0.0182648401826484
REAC REAC:R-HSA-6802949 Signaling by RAS mutants 0.00147703127379956 45 25 3 0.12 0.0666666666666667
REAC REAC:R-HSA-6802952 Signaling by BRAF and RAF fusions 0.00396215631293132 64 25 3 0.12 0.046875
REAC REAC:R-HSA-3928662 EPHB-mediated forward signaling 0.00591866490722924 40 46 3 0.0652173913043478 0.075
REAC REAC:R-HSA-6802957 Oncogenic MAPK signaling 0.00752427158458303 82 25 3 0.12 0.0365853658536585
REAC REAC:R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 0.0125216298097575 35 70 3 0.0428571428571429 0.0857142857142857
REAC REAC:R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.0127572607834724 116 78 5 0.0641025641025641 0.0431034482758621
REAC REAC:R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.0272559857366655 140 78 5 0.0641025641025641 0.0357142857142857
REAC REAC:R-HSA-5683057 MAPK family signaling cascades 0.0473730444102128 308 27 4 0.148148148148148 0.012987012987013
TF TF:M01007 Factor: SRF; motif: CNKNKCCTTATWTGGNNNN 2.29614743316193e-06 256 34 9 0.264705882352941 0.03515625
TF TF:M10076 Factor: SRF; motif: TTNCCWTWTWTGGNCWNN 2.64253022990295e-06 187 34 8 0.235294117647059 0.0427807486631016
TF TF:M01304 Factor: SRF; motif: NNCCAWAWAAGGV 4.44125611415548e-06 218 34 8 0.235294117647059 0.036697247706422
TF TF:M00152 Factor: SRF; motif: ATGCCCATATATGGWNNT 4.44125611415548e-06 182 78 10 0.128205128205128 0.0549450549450549
TF TF:M00922 Factor: SRF; motif: CCAWATAWGGMNMNG 1.02553291325369e-05 291 130 14 0.107692307692308 0.0481099656357388
TF TF:M00186 Factor: SRF; motif: GNCCAWATAWGGMN 1.34748558405788e-05 172 125 11 0.088 0.063953488372093
TF TF:M01257 Factor: SRF; motif: NNCCAWAWAAGGNMANNN 1.66732853878756e-05 177 34 7 0.205882352941176 0.0395480225988701
TF TF:M11697 Factor: MEF-2B1; motif: CCNWATWNRG 2.85245138936448e-05 1096 78 19 0.243589743589744 0.0173357664233577
TF TF:M00215 Factor: SRF; motif: DCCWTATATGGNCWN 7.58935533061336e-05 147 78 8 0.102564102564103 0.054421768707483
TF TF:M07618 Factor: SRF; motif: CCTTWTATGGNN 7.58935533061336e-05 167 15 5 0.333333333333333 0.029940119760479
TF TF:M11694 Factor: MEF-2D; motif: CCWWATWTRG 9.48759247753707e-05 359 78 11 0.141025641025641 0.0306406685236769
TF TF:M11692 Factor: MEF-2C; motif: CCAWATWTRG 0.000211825959206322 1103 81 18 0.222222222222222 0.0163191296464189
TF TF:M11696_1 Factor: MEF-2B1; motif: CCNWATWWRG; match class: 1 0.000256398741647806 898 18 8 0.444444444444444 0.0089086859688196
TF TF:M03896 Factor: EGR1; motif: NACGCCCACGCANW 0.00030147679488202 6129 84 48 0.571428571428571 0.00783162016642193
TF TF:M11696 Factor: MEF-2B1; motif: CCNWATWWRG 0.000453567780821719 2268 37 16 0.432432432432432 0.00705467372134039
TF TF:M05327 Factor: WT1; motif: NGCGGGGGGGTSMMCYN 0.00102434411180574 5509 90 46 0.511111111111111 0.00834997277182792
TF TF:M10529 Factor: Sp1; motif: RGGGMGGRGSNGGGG 0.00102434411180574 6891 116 65 0.560344827586207 0.00943259323755623
TF TF:M04680_1 Factor: SRF; motif: CCWTATAWG; match class: 1 0.00160863227597932 36 61 4 0.0655737704918033 0.111111111111111
TF TF:M06531 Factor: ZNF555; motif: NCRWGTTTGKCC 0.00170960441060439 244 130 10 0.0769230769230769 0.040983606557377
TF TF:M11693 Factor: MEF-2C; motif: CCWWATWTRG 0.00228507899066949 392 37 7 0.189189189189189 0.0178571428571429
TF TF:M07289 Factor: GKLF; motif: NNNRGGNGNGGSN 0.00375071940352352 14646 120 108 0.9 0.00737402703809914
TF TF:M11694_1 Factor: MEF-2D; motif: CCWWATWTRG; match class: 1 0.00375071940352352 131 78 6 0.0769230769230769 0.0458015267175573
TF TF:M11693_1 Factor: MEF-2C; motif: CCWWATWTRG; match class: 1 0.00375071940352352 132 78 6 0.0769230769230769 0.0454545454545455
TF TF:M10026 Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN 0.00375071940352352 8389 131 80 0.610687022900763 0.00953629753248301
TF TF:M11695 Factor: MEF-2D; motif: CCAWATWTRG 0.00464228832328232 288 78 8 0.102564102564103 0.0277777777777778
TF TF:M10432_1 Factor: MAZ; motif: GGGMGGGGS; match class: 1 0.00519232253178794 4365 124 48 0.387096774193548 0.0109965635738832
TF TF:M11697_1 Factor: MEF-2B1; motif: CCNWATWNRG; match class: 1 0.00519232253178794 683 18 6 0.333333333333333 0.00878477306002928
TF TF:M00810 Factor: SRF; motif: SCCAWATAWGGMNMNNNN 0.0061719290313016 109 106 6 0.0566037735849057 0.055045871559633
TF TF:M07436 Factor: WT1; motif: NNGGGNGGGSGN 0.00625362400818545 6182 127 62 0.488188976377953 0.0100291167906826
TF TF:M00470 Factor: AP-2gamma; motif: GCCYNNGGS 0.0064596829885866 9422 105 71 0.676190476190476 0.00753555508384632
TF TF:M11692_1 Factor: MEF-2C; motif: CCAWATWTRG; match class: 1 0.00909884347343726 162 78 6 0.0769230769230769 0.037037037037037
TF TF:M07461 Factor: KLF; motif: GGGNGGGG 0.00953414807049615 8757 16 15 0.9375 0.00171291538198013
TF TF:M00470_1 Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 0.00979331884117701 5600 105 49 0.466666666666667 0.00875
TF TF:M07235_1 Factor: ZEB1; motif: NCWCACCTG; match class: 1 0.00979331884117701 81 18 3 0.166666666666667 0.037037037037037
TF TF:M07397_1 Factor: ZBP89; motif: CCCCKCCCCCNN; match class: 1 0.0105427335024119 2951 116 34 0.293103448275862 0.0115215181294476
TF TF:M12313 Factor: ZNF460; motif: NNACNCCCCCCNN 0.0109378637015522 5825 13 11 0.846153846153846 0.00188841201716738
TF TF:M00469_1 Factor: AP-2alpha; motif: GCCNNNRGS; match class: 1 0.0114423763756848 3334 88 30 0.340909090909091 0.00899820035992801
TF TF:M10948_1 Factor: rax; motif: NNCRTTAN; match class: 1 0.0114423763756848 5245 54 28 0.518518518518518 0.00533841754051478
TF TF:M00649 Factor: MAZ; motif: GGGGAGGG 0.0121271787726119 9327 131 84 0.641221374045801 0.0090061112898038
TF TF:M08867_1 Factor: AP2; motif: GCCYGSGGSN; match class: 1 0.0122617079391457 5186 85 39 0.458823529411765 0.00752024681835712
TF TF:M01873 Factor: Egr-1; motif: GCGGGGGCGG 0.0126486453973336 6738 84 46 0.547619047619048 0.00682695161769071
TF TF:M07417 Factor: Elf-1; motif: NNCAGGAAGNNN 0.0126486453973336 1774 130 26 0.2 0.0146561443066516
TF TF:M10661 Factor: LBX2; motif: CTMATTAATTAT 0.0137306473438532 187 112 7 0.0625 0.0374331550802139
TF TF:M03876_1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 0.0137306473438532 9106 127 80 0.62992125984252 0.00878541620909291
TF TF:M10432 Factor: MAZ; motif: GGGMGGGGS 0.0137306473438532 9259 127 81 0.637795275590551 0.00874824495085862
TF TF:M12140 Factor: Egr-1; motif: NNCRCCCMCGCNN 0.0142517382712041 5360 78 37 0.474358974358974 0.00690298507462687
TF TF:M07354 Factor: Egr-1; motif: GCGGGGGCGG 0.0144259352178253 7801 83 50 0.602409638554217 0.00640943468786053
TF TF:M04680 Factor: SRF; motif: CCWTATAWG 0.0144259352178253 152 61 5 0.0819672131147541 0.0328947368421053
TF TF:M00469 Factor: AP-2alpha; motif: GCCNNNRGS 0.0144594405529718 5147 131 54 0.412213740458015 0.0104915484748397
TF TF:M01104_1 Factor: MOVO-B; motif: GNGGGGG; match class: 1 0.0144594405529718 5626 83 40 0.481927710843373 0.00710984713828653
TF TF:M03876 Factor: Kaiso; motif: GCMGGGRGCRGS 0.0145642362908042 13622 124 104 0.838709677419355 0.00763470855968287
TF TF:M11695_1 Factor: MEF-2D; motif: CCAWATWTRG; match class: 1 0.0145642362908042 195 78 6 0.0769230769230769 0.0307692307692308
TF TF:M02036_1 Factor: WT1; motif: CGCCCCCNCN; match class: 1 0.0145642362908042 5290 131 55 0.419847328244275 0.0103969754253308
TF TF:M09739 Factor: ZGPAT; motif: GRGGCWGNGGNG 0.0145642362908042 8226 46 32 0.695652173913043 0.00389010454655969
TF TF:M00054 Factor: NF-kappaB; motif: GGGAMTTYCC 0.0154962268656619 2444 99 26 0.262626262626263 0.0106382978723404
TF TF:M07289_1 Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1 0.0157188359143375 10555 131 91 0.694656488549618 0.00862150639507342
TF TF:M12092 Factor: ZNF787; motif: TGCCTCAGTTTMCCN 0.0161980461779063 634 90 11 0.122222222222222 0.0173501577287066
TF TF:M11347 Factor: MafG; motif: NTGCTGAYGTCAGCAN 0.0180171728785157 1478 93 18 0.193548387096774 0.0121786197564276
TF TF:M10491_1 Factor: ZNF586; motif: CAGGCCYRGAGG; match class: 1 0.0233103492041278 7720 9 9 1 0.00116580310880829
TF TF:M10529_1 Factor: Sp1; motif: RGGGMGGRGSNGGGG; match class: 1 0.0239853113647974 2816 119 32 0.26890756302521 0.0113636363636364
TF TF:M09984_1 Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1 0.0243037124520529 5555 131 56 0.427480916030534 0.0100810081008101
TF TF:M10107 Factor: DB1; motif: GGRRRRGRRGGAGGGGGNGRRR 0.0243037124520529 5822 131 58 0.442748091603053 0.00996221229817932
TF TF:M01118 Factor: WT1; motif: SMCNCCNSC 0.0243037124520529 6808 126 63 0.5 0.00925381903642773
TF TF:M00807_1 Factor: Egr; motif: GTGGGSGCRRS; match class: 1 0.025836527904189 819 15 5 0.333333333333333 0.00610500610500611
TF TF:M01835 Factor: GKLF; motif: CCTCCYN 0.0274892141100195 15620 131 119 0.908396946564885 0.00761843790012804
TF TF:M01175 Factor: CKROX; motif: SCCCTCCCC 0.0281067307274031 7292 126 66 0.523809523809524 0.00905101481075151
TF TF:M09984 Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG 0.0315008997140488 9544 127 81 0.637795275590551 0.00848700754400671
TF TF:M11830 Factor: LRH-1; motif: TGACCTTGRNYCAAGGTCA 0.0321825376958948 7061 18 14 0.777777777777778 0.00198272199405183
TF TF:M11830_1 Factor: LRH-1; motif: TGACCTTGRNYCAAGGTCA; match class: 1 0.0347170857805011 6100 18 13 0.722222222222222 0.00213114754098361
TF TF:M08878 Factor: EGR; motif: CGCCCCCGCNN 0.0374753000828768 7483 83 47 0.566265060240964 0.00628090338099693
TF TF:M02105 Factor: NF-E4; motif: CHCCCTCKCCWG 0.0374753000828768 2647 93 25 0.268817204301075 0.00944465432565168
TF TF:M04595 Factor: SALL2; motif: GGGTGGG 0.0374949482683058 13013 25 24 0.96 0.00184430953661723
TF TF:M09603_1 Factor: Egr-1; motif: NNNNNGYGKGGGNGGGNN; match class: 1 0.0381215483345676 1317 112 18 0.160714285714286 0.0136674259681093
TF TF:M10071 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG 0.0401970569964326 8495 47 32 0.680851063829787 0.00376692171865803
TF TF:M07348_1 Factor: AP-2alpha; motif: NSCCNCRGGSN; match class: 1 0.040940817250049 2945 85 25 0.294117647058824 0.00848896434634975
TF TF:M05332_1 Factor: Sp2; motif: WGGGCGG; match class: 1 0.0414868719502783 3313 85 27 0.317647058823529 0.00814971325083006
TF TF:M05361_1 Factor: Sp6; motif: WGGGCGG; match class: 1 0.0414868719502783 3313 85 27 0.317647058823529 0.00814971325083006
TF TF:M05444_1 Factor: CPBP; motif: NGGGCGG; match class: 1 0.0414868719502783 3313 85 27 0.317647058823529 0.00814971325083006
TF TF:M00915_1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 0.0415835543272251 4551 103 39 0.378640776699029 0.00856954515491101
TF TF:M08878_1 Factor: EGR; motif: CGCCCCCGCNN; match class: 1 0.0421993899512999 3224 83 26 0.313253012048193 0.00806451612903226
TF TF:M07040 Factor: GKLF; motif: NNRRGRRNGNSNNN 0.0432455119090732 12705 128 100 0.78125 0.00787091696182605
TF TF:M07341 Factor: TORC2; motif: TGGGCTKKD 0.0446314537305391 4887 17 11 0.647058823529412 0.00225086965418457
TF TF:M07226 Factor: SP1; motif: NCCCCKCCCCC 0.0449507609804828 8292 131 74 0.564885496183206 0.00892426435118186
TF TF:M07602_1 Factor: CP2; motif: NNNNCCAGNCNN; match class: 1 0.0453102771149477 4627 13 9 0.692307692307692 0.0019451048195375
TF TF:M12147 Factor: SP8; motif: RNCACGCCCMCN 0.0453102771149477 2465 69 19 0.27536231884058 0.0077079107505071
TF TF:M07040_1 Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1 0.0468223519807914 8156 127 71 0.559055118110236 0.00870524767042668
TF TF:M10008 Factor: CSX; motif: NKRAGWGS 0.0468223519807914 10145 40 31 0.775 0.00305569245933958
TF TF:M10107_1 Factor: DB1; motif: GGRRRRGRRGGAGGGGGNGRRR; match class: 1 0.0472582402432579 2657 122 30 0.245901639344262 0.011290929619872
TF TF:M00933 Factor: Sp1; motif: CCCCGCCCCN 0.0472582402432579 9715 127 81 0.637795275590551 0.00833762223365929
TF TF:M00915 Factor: AP-2; motif: SNNNCCNCAGGCN 0.0472582402432579 9612 14 13 0.928571428571429 0.0013524760715772
TF TF:M03567_1 Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 0.0472582402432579 3614 13 8 0.615384615384615 0.00221361372440509
WP WP:WP306 Focal Adhesion 3.52927334701952e-08 201 26 10 0.384615384615385 0.0497512437810945
WP WP:WP383 Striated Muscle Contraction Pathway 3.52927334701952e-08 38 19 6 0.315789473684211 0.157894736842105
WP WP:WP4560 MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement 7.39644590837997e-06 18 22 4 0.181818181818182 0.222222222222222
WP WP:WP51 Regulation of Actin Cytoskeleton 6.18069506943902e-05 149 75 10 0.133333333333333 0.0671140939597315
WP WP:WP4534 Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms 0.000511836308184942 47 9 3 0.333333333333333 0.0638297872340425
WP WP:WP2572 Primary Focal Segmental Glomerulosclerosis FSGS 0.00201057198452605 74 47 5 0.106382978723404 0.0675675675675676
WP WP:WP4217 Ebola Virus Pathway on Host 0.00524126087668713 130 19 4 0.210526315789474 0.0307692307692308
WP WP:WP2118 Arrhythmogenic Right Ventricular Cardiomyopathy 0.0146292120926193 76 19 3 0.157894736842105 0.0394736842105263
WP WP:WP289 Myometrial Relaxation and Contraction Pathways 0.0181763247192171 155 24 4 0.166666666666667 0.0258064516129032
WP WP:WP524 G13 Signaling Pathway 0.0302694034130246 40 51 3 0.0588235294117647 0.075

pS03 transcription factor target enrichment of top program genes

TF enrichment of pS03
TFs corrosponding to activation of pS03. (Left) pearson correlation of TF expression and gene expression program activatity in Stromal cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.