pTNI14 (gd-like T)

pTNI14 program activity among T/NK/ILC cells
pTNI14 top program genes
pTNI14 gene-set enrichment of top program genes (using g-profiler)
pTNI14 transcription factor target enrichment of top program genes

pTNI14 program activity among T/NK/ILC cells

Activation of pTNI14 — pTNI14 gene program activation in T/NK/ILC cells.

Gene program activation of pTNI14 by different cell subtypes — pTNI14 gene program activation among cells of different subtypes (T/NK/ILC cells).

pTNI14 top program genes

Top genes of pTNI14 program — Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pTNI14 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pTNI14 — pTNI14 gene-set enrichment summary using g-profiler webtool.

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Source	termID	Name	Padj	Tsize	Qsize	Overlap	Precision	Recall
GO:BP	GO:0002727	regulation of natural killer cell cytokine production	2.41478535252382e-05	9	13	3	0.230769230769231	0.333333333333333
GO:BP	GO:0002370	natural killer cell cytokine production	2.41478535252382e-05	9	13	3	0.230769230769231	0.333333333333333
GO:BP	GO:0002715	regulation of natural killer cell mediated immunity	0.000104025673754932	45	20	4	0.2	0.0888888888888889
GO:BP	GO:0002228	natural killer cell mediated immunity	0.000349541778234843	65	20	4	0.2	0.0615384615384615
GO:BP	GO:0002440	production of molecular mediator of immune response	0.00048332789818523	189	19	5	0.263157894736842	0.0264550264550265
GO:BP	GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway	0.000638844033616346	15	31	3	0.0967741935483871	0.2
GO:BP	GO:0035590	purinergic nucleotide receptor signaling pathway	0.000638844033616346	34	50	4	0.08	0.117647058823529
GO:BP	GO:0002717	positive regulation of natural killer cell mediated immunity	0.00114400277062893	30	20	3	0.15	0.1
GO:BP	GO:0032814	regulation of natural killer cell activation	0.00163353829319831	35	20	3	0.15	0.0857142857142857
GO:BP	GO:0042269	regulation of natural killer cell mediated cytotoxicity	0.00198702598975774	41	20	3	0.15	0.0731707317073171

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pTNI14 transcription factor target enrichment of top program genes

TF enrichment of pTNI14 — TFs corrosponding to activation of pTNI14. (Left) pearson correlation of TF expression and gene expression program activatity in T/NK/ILC cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.