pEpiTp07 program activity among Epithelial cells

Activation of pEpiTp07
pEpiTp07 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp07 by different cell subtypes
pEpiTp07 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp07 top program genes

Top genes of pEpiTp07 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp07 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp07
pEpiTp07 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0006959 humoral immune response 0.00015124525881189 384 94 13 0.138297872340426 0.0338541666666667
GO:BP GO:0019730 antimicrobial humoral response 0.00015124525881189 145 15 5 0.333333333333333 0.0344827586206897
GO:BP GO:0050900 leukocyte migration 0.000153739856029848 511 51 11 0.215686274509804 0.0215264187866928
GO:BP GO:0050853 B cell receptor signaling pathway 0.000417274252493784 135 94 8 0.0851063829787234 0.0592592592592593
GO:BP GO:0050871 positive regulation of B cell activation 0.000488720577837738 151 94 8 0.0851063829787234 0.0529801324503311
GO:BP GO:0050864 regulation of B cell activation 0.000488720577837738 194 96 9 0.09375 0.0463917525773196
GO:BP GO:0048871 multicellular organismal homeostasis 0.000488720577837738 530 60 11 0.183333333333333 0.0207547169811321
GO:BP GO:0006910 phagocytosis, recognition 0.000488720577837738 98 94 7 0.074468085106383 0.0714285714285714
GO:BP GO:0002252 immune effector process 0.000575215181607814 1309 33 12 0.363636363636364 0.00916730328495034
GO:BP GO:0042742 defense response to bacterium 0.000575215181607814 349 45 8 0.177777777777778 0.0229226361031519
GO:BP GO:0042113 B cell activation 0.000575215181607814 330 143 13 0.0909090909090909 0.0393939393939394
GO:BP GO:0016477 cell migration 0.000575215181607814 1649 69 20 0.289855072463768 0.0121285627653123
GO:BP GO:0002443 leukocyte mediated immunity 0.000575215181607814 877 33 10 0.303030303030303 0.0114025085518814
GO:BP GO:0001894 tissue homeostasis 0.0006371516260202 270 60 8 0.133333333333333 0.0296296296296296
GO:BP GO:0001895 retina homeostasis 0.0006371516260202 79 23 4 0.173913043478261 0.0506329113924051
GO:BP GO:0008037 cell recognition 0.000757888792767925 235 94 9 0.0957446808510638 0.0382978723404255
GO:BP GO:0006911 phagocytosis, engulfment 0.00083267496140273 127 94 7 0.074468085106383 0.0551181102362205
GO:BP GO:0019731 antibacterial humoral response 0.00083267496140273 62 10 3 0.3 0.0483870967741935
GO:BP GO:0045087 innate immune response 0.000873004975132663 998 46 12 0.260869565217391 0.0120240480961924
GO:BP GO:0099024 plasma membrane invagination 0.00113827175059749 136 94 7 0.074468085106383 0.0514705882352941
GO:BP GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase 0.00121341800659166 11 70 3 0.0428571428571429 0.272727272727273
GO:BP GO:0006958 complement activation, classical pathway 0.00121341800659166 142 94 7 0.074468085106383 0.0492957746478873
GO:BP GO:0042592 homeostatic process 0.00121341800659166 1981 125 31 0.248 0.0156486622917718
GO:BP GO:0048870 cell motility 0.00121341800659166 1828 69 20 0.289855072463768 0.0109409190371991
GO:BP GO:0051674 localization of cell 0.00121341800659166 1828 69 20 0.289855072463768 0.0109409190371991
GO:BP GO:0006955 immune response 0.00121341800659166 2311 94 28 0.297872340425532 0.0121159671138035
GO:BP GO:0010324 membrane invagination 0.00121341800659166 144 94 7 0.074468085106383 0.0486111111111111
GO:BP GO:0009893 positive regulation of metabolic process 0.00186055711130758 3783 41 21 0.51219512195122 0.00555114988104679
GO:BP GO:0002455 humoral immune response mediated by circulating immunoglobulin 0.00186055711130758 156 94 7 0.074468085106383 0.0448717948717949
GO:BP GO:0016064 immunoglobulin mediated immune response 0.00190456004938295 223 45 6 0.133333333333333 0.0269058295964126
GO:BP GO:0019724 B cell mediated immunity 0.0019898072266223 226 45 6 0.133333333333333 0.0265486725663717
GO:BP GO:0048522 positive regulation of cellular process 0.00228870733603625 5757 45 28 0.622222222222222 0.00486364425916276
GO:BP GO:0048518 positive regulation of biological process 0.00228870733603625 6363 60 37 0.616666666666667 0.00581486720100581
GO:BP GO:0051707 response to other organism 0.00228870733603625 1592 46 14 0.304347826086957 0.00879396984924623
GO:BP GO:0002449 lymphocyte mediated immunity 0.00228870733603625 354 45 7 0.155555555555556 0.019774011299435
GO:BP GO:0043207 response to external biotic stimulus 0.00228870733603625 1594 46 14 0.304347826086957 0.00878293601003764
GO:BP GO:0009617 response to bacterium 0.00239105342372513 743 94 14 0.148936170212766 0.018842530282638
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.00239902672918786 363 45 7 0.155555555555556 0.0192837465564738
GO:BP GO:0009607 response to biotic stimulus 0.00258070745568314 1626 46 14 0.304347826086957 0.00861008610086101
GO:BP GO:0040011 locomotion 0.00258299982999269 2028 73 21 0.287671232876712 0.0103550295857988
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.00284088666810276 323 138 11 0.0797101449275362 0.0340557275541796
GO:BP GO:0098542 defense response to other organism 0.00284088666810276 1218 46 12 0.260869565217391 0.00985221674876847
GO:BP GO:0002250 adaptive immune response 0.00290211151186153 689 45 9 0.2 0.0130624092888244
GO:BP GO:0002376 immune system process 0.00290211151186153 3278 96 34 0.354166666666667 0.0103721781574131
GO:BP GO:0001775 cell activation 0.00290211151186153 1495 33 11 0.333333333333333 0.00735785953177258
GO:BP GO:0006956 complement activation 0.0029162142503643 180 94 7 0.074468085106383 0.0388888888888889
GO:BP GO:0006950 response to stress 0.00392029233671539 4170 46 23 0.5 0.00551558752997602
GO:BP GO:0045321 leukocyte activation 0.00399957401600036 1332 96 19 0.197916666666667 0.0142642642642643
GO:BP GO:0002274 myeloid leukocyte activation 0.00399957401600036 667 20 6 0.3 0.00899550224887556
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.00438852096307442 3483 41 19 0.463414634146341 0.00545506747057135
GO:BP GO:0009653 anatomical structure morphogenesis 0.00529068185346259 2797 143 40 0.27972027972028 0.0143010368251698
GO:BP GO:0045785 positive regulation of cell adhesion 0.00535600846545053 437 20 5 0.25 0.011441647597254
GO:BP GO:0002263 cell activation involved in immune response 0.00536202755043471 721 20 6 0.3 0.00832177531206657
GO:BP GO:0060081 membrane hyperpolarization 0.00665935184441337 14 130 3 0.0230769230769231 0.214285714285714
GO:BP GO:0016192 vesicle-mediated transport 0.00673196157713786 2180 15 8 0.533333333333333 0.0036697247706422
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.00740228027898078 512 138 13 0.0942028985507246 0.025390625
GO:BP GO:0002764 immune response-regulating signaling pathway 0.00750411013317573 515 138 13 0.0942028985507246 0.0252427184466019
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.00750411013317573 365 143 11 0.0769230769230769 0.0301369863013699
GO:BP GO:0060249 anatomical structure homeostasis 0.0083182961932802 482 60 8 0.133333333333333 0.016597510373444
GO:BP GO:0009887 animal organ morphogenesis 0.00869542469023205 1073 36 9 0.25 0.00838769804287046
GO:BP GO:0006928 movement of cell or subcellular component 0.00913029141502374 2311 126 31 0.246031746031746 0.0134141064474254
GO:BP GO:0032892 positive regulation of organic acid transport 0.00918809105067737 41 51 3 0.0588235294117647 0.0731707317073171
GO:BP GO:0050896 response to stimulus 0.00918809105067737 9407 21 19 0.904761904761905 0.0020197725098331
GO:BP GO:0006897 endocytosis 0.00924141839752614 696 33 7 0.212121212121212 0.0100574712643678
GO:BP GO:0002011 morphogenesis of an epithelial sheet 0.00943644064244057 58 37 3 0.0810810810810811 0.0517241379310345
GO:BP GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 0.00995953524535559 135 117 6 0.0512820512820513 0.0444444444444444
GO:BP GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 0.00995953524535559 135 117 6 0.0512820512820513 0.0444444444444444
GO:BP GO:0038094 Fc-gamma receptor signaling pathway 0.0103368541023678 137 117 6 0.0512820512820513 0.0437956204379562
GO:BP GO:0022604 regulation of cell morphogenesis 0.0103368541023678 309 19 4 0.210526315789474 0.0129449838187702
GO:BP GO:0030449 regulation of complement activation 0.0104152392560246 110 94 5 0.0531914893617021 0.0454545454545455
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.0110947817351117 477 138 12 0.0869565217391304 0.0251572327044025
GO:BP GO:0002757 immune response-activating signal transduction 0.0110947817351117 477 138 12 0.0869565217391304 0.0251572327044025
GO:BP GO:0002431 Fc receptor mediated stimulatory signaling pathway 0.0112569095815141 141 117 6 0.0512820512820513 0.0425531914893617
GO:BP GO:0070887 cellular response to chemical stimulus 0.0112569095815141 3393 20 11 0.55 0.00324196875921014
GO:BP GO:0001659 temperature homeostasis 0.0112569095815141 174 133 7 0.0526315789473684 0.0402298850574713
GO:BP GO:0031589 cell-substrate adhesion 0.0112727743601849 367 46 6 0.130434782608696 0.0163487738419619
GO:BP GO:0045055 regulated exocytosis 0.0112727743601849 785 15 5 0.333333333333333 0.00636942675159236
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0114784395460154 3210 133 40 0.300751879699248 0.0124610591900312
GO:BP GO:0042221 response to chemical 0.0114784395460154 4781 20 13 0.65 0.0027190964233424
GO:BP GO:0006915 apoptotic process 0.0122822033559289 1990 27 10 0.37037037037037 0.0050251256281407
GO:BP GO:0006952 defense response 0.0127826134953723 1818 46 13 0.282608695652174 0.00715071507150715
GO:BP GO:0070372 regulation of ERK1 and ERK2 cascade 0.0127826134953723 309 21 4 0.19047619047619 0.0129449838187702
GO:BP GO:0046649 lymphocyte activation 0.0127826134953723 771 143 16 0.111888111888112 0.0207522697795071
GO:BP GO:0002696 positive regulation of leukocyte activation 0.0127826134953723 412 143 11 0.0769230769230769 0.0266990291262136
GO:BP GO:0055076 transition metal ion homeostasis 0.0127826134953723 138 125 6 0.048 0.0434782608695652
GO:BP GO:0048584 positive regulation of response to stimulus 0.0127826134953723 2344 60 18 0.3 0.00767918088737201
GO:BP GO:0032990 cell part morphogenesis 0.0127826134953723 699 143 15 0.104895104895105 0.0214592274678112
GO:BP GO:0032940 secretion by cell 0.0136583138979995 1364 15 6 0.4 0.00439882697947214
GO:BP GO:0070371 ERK1 and ERK2 cascade 0.0136583138979995 329 21 4 0.19047619047619 0.0121580547112462
GO:BP GO:0032989 cellular component morphogenesis 0.01401408852983 791 143 16 0.111888111888112 0.0202275600505689
GO:BP GO:0043312 neutrophil degranulation 0.0142433964883135 482 15 4 0.266666666666667 0.00829875518672199
GO:BP GO:0050867 positive regulation of cell activation 0.0144426762892859 424 143 11 0.0769230769230769 0.0259433962264151
GO:BP GO:0002283 neutrophil activation involved in immune response 0.0144426762892859 485 15 4 0.266666666666667 0.00824742268041237
GO:BP GO:0042327 positive regulation of phosphorylation 0.0145824148671568 927 57 10 0.175438596491228 0.0107874865156419
GO:BP GO:0006887 exocytosis 0.0150281191954318 904 15 5 0.333333333333333 0.00553097345132743
GO:BP GO:0043408 regulation of MAPK cascade 0.0150281191954318 730 27 6 0.222222222222222 0.00821917808219178
GO:BP GO:0042119 neutrophil activation 0.0150281191954318 498 15 4 0.266666666666667 0.00803212851405622
GO:BP GO:0002446 neutrophil mediated immunity 0.0150281191954318 497 15 4 0.266666666666667 0.00804828973843058
GO:BP GO:0140352 export from cell 0.0151361800790794 1418 15 6 0.4 0.00423131170662906
GO:BP GO:0036230 granulocyte activation 0.0153770905843646 504 15 4 0.266666666666667 0.00793650793650794
GO:BP GO:0048878 chemical homeostasis 0.0153912299017226 1229 133 20 0.150375939849624 0.016273393002441
GO:BP GO:0002920 regulation of humoral immune response 0.015411051162371 133 94 5 0.0531914893617021 0.037593984962406
GO:BP GO:0012501 programmed cell death 0.0155392653825444 2143 27 10 0.37037037037037 0.00466635557629491
GO:BP GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 0.0155392653825444 103 122 5 0.040983606557377 0.0485436893203883
GO:BP GO:0034614 cellular response to reactive oxygen species 0.0157988163809842 170 19 3 0.157894736842105 0.0176470588235294
GO:BP GO:0060429 epithelium development 0.0157988163809842 1325 42 10 0.238095238095238 0.00754716981132075
GO:BP GO:0032469 endoplasmic reticulum calcium ion homeostasis 0.0157988163809842 26 122 3 0.0245901639344262 0.115384615384615
GO:BP GO:0030155 regulation of cell adhesion 0.0157988163809842 748 37 7 0.189189189189189 0.00935828877005348
GO:BP GO:0048593 camera-type eye morphogenesis 0.0157988163809842 126 101 5 0.0495049504950495 0.0396825396825397
GO:BP GO:0032370 positive regulation of lipid transport 0.0157988163809842 87 84 4 0.0476190476190476 0.0459770114942529
GO:BP GO:0070633 transepithelial transport 0.0157988163809842 31 103 3 0.029126213592233 0.0967741935483871
GO:BP GO:0046903 secretion 0.0168648390843033 1501 20 7 0.35 0.00466355762824783
GO:BP GO:0043299 leukocyte degranulation 0.017007093977495 535 15 4 0.266666666666667 0.00747663551401869
GO:BP GO:0090596 sensory organ morphogenesis 0.0175594442238368 262 136 8 0.0588235294117647 0.0305343511450382
GO:BP GO:0051249 regulation of lymphocyte activation 0.0178205277570502 518 143 12 0.0839160839160839 0.0231660231660232
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.018129242774591 547 15 4 0.266666666666667 0.00731261425959781
GO:BP GO:0030330 DNA damage response, signal transduction by p53 class mediator 0.018257540000623 110 122 5 0.040983606557377 0.0454545454545455
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.018257540000623 551 15 4 0.266666666666667 0.00725952813067151
GO:BP GO:0038093 Fc receptor signaling pathway 0.018257540000623 238 33 4 0.121212121212121 0.0168067226890756
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0183417909809172 717 20 5 0.25 0.00697350069735007
GO:BP GO:0030855 epithelial cell differentiation 0.0184555446797826 798 108 13 0.12037037037037 0.0162907268170426
GO:BP GO:0032890 regulation of organic acid transport 0.0184555446797826 68 51 3 0.0588235294117647 0.0441176470588235
GO:BP GO:0120039 plasma membrane bounded cell projection morphogenesis 0.0189253298803546 678 143 14 0.0979020979020979 0.0206489675516224
GO:BP GO:0050892 intestinal absorption 0.0189253298803546 40 88 3 0.0340909090909091 0.075
GO:BP GO:0048858 cell projection morphogenesis 0.0191232386972006 682 143 14 0.0979020979020979 0.0205278592375367
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0191232386972006 2255 46 14 0.304347826086957 0.00620842572062084
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 0.0191232386972006 1001 57 10 0.175438596491228 0.00999000999000999
GO:BP GO:0045937 positive regulation of phosphate metabolic process 0.0191232386972006 1001 57 10 0.175438596491228 0.00999000999000999
GO:BP GO:1905606 regulation of presynapse assembly 0.0191232386972006 34 106 3 0.0283018867924528 0.0882352941176471
GO:BP GO:0099174 regulation of presynapse organization 0.0191232386972006 34 106 3 0.0283018867924528 0.0882352941176471
GO:BP GO:0048592 eye morphogenesis 0.0191232386972006 155 133 6 0.0451127819548872 0.0387096774193548
GO:BP GO:0000902 cell morphogenesis 0.0191232386972006 1037 117 16 0.136752136752137 0.0154291224686596
GO:BP GO:0010810 regulation of cell-substrate adhesion 0.0195188249593093 222 37 4 0.108108108108108 0.018018018018018
GO:BP GO:0008219 cell death 0.0200377848359227 2292 36 12 0.333333333333333 0.00523560209424084
GO:BP GO:0009605 response to external stimulus 0.020319259016283 2944 74 23 0.310810810810811 0.0078125
GO:BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 0.0207275705842638 215 39 4 0.102564102564103 0.0186046511627907
GO:BP GO:0001934 positive regulation of protein phosphorylation 0.0207493307980199 840 57 9 0.157894736842105 0.0107142857142857
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.0215022962268419 1227 19 6 0.315789473684211 0.00488997555012225
GO:BP GO:0006979 response to oxidative stress 0.0218157817075528 466 19 4 0.210526315789474 0.00858369098712446
GO:BP GO:0032922 circadian regulation of gene expression 0.0221047729748524 67 127 4 0.031496062992126 0.0597014925373134
GO:BP GO:0065008 regulation of biological quality 0.0223642364923877 4131 133 46 0.345864661654135 0.0111353183248608
GO:BP GO:0002253 activation of immune response 0.0232646272956837 568 138 12 0.0869565217391304 0.0211267605633803
GO:BP GO:0001836 release of cytochrome c from mitochondria 0.0240275831961864 59 68 3 0.0441176470588235 0.0508474576271186
GO:BP GO:0048583 regulation of response to stimulus 0.0246445340410782 4278 60 25 0.416666666666667 0.00584385226741468
GO:BP GO:0010941 regulation of cell death 0.024673365554873 1720 36 10 0.277777777777778 0.00581395348837209
GO:BP GO:0140353 lipid export from cell 0.024674666729536 88 101 4 0.0396039603960396 0.0454545454545455
GO:BP GO:0050776 regulation of immune response 0.024674666729536 996 60 10 0.166666666666667 0.0100401606425703
GO:BP GO:0003007 heart morphogenesis 0.0247685517414207 251 36 4 0.111111111111111 0.0159362549800797
GO:BP GO:0009409 response to cold 0.0248550817965555 48 86 3 0.0348837209302326 0.0625
GO:BP GO:0022600 digestive system process 0.0248550817965555 102 88 4 0.0454545454545455 0.0392156862745098
GO:BP GO:0043067 regulation of programmed cell death 0.0258001498691879 1582 27 8 0.296296296296296 0.00505689001264223
GO:BP GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 0.0283196525731013 77 122 4 0.0327868852459016 0.051948051948052
GO:BP GO:0000302 response to reactive oxygen species 0.0284054950082155 237 19 3 0.157894736842105 0.0126582278481013
GO:BP GO:1905954 positive regulation of lipid localization 0.0286771302910759 113 84 4 0.0476190476190476 0.0353982300884956
GO:BP GO:0051716 cellular response to stimulus 0.0288511282199194 7781 46 30 0.652173913043478 0.0038555455596967
GO:BP GO:2001234 negative regulation of apoptotic signaling pathway 0.0289708839837718 236 68 5 0.0735294117647059 0.0211864406779661
GO:BP GO:0006687 glycosphingolipid metabolic process 0.0299556676721217 68 142 4 0.028169014084507 0.0588235294117647
GO:BP GO:0010811 positive regulation of cell-substrate adhesion 0.0304920976129437 124 37 3 0.0810810810810811 0.0241935483870968
GO:BP GO:0018108 peptidyl-tyrosine phosphorylation 0.0306658542852886 385 26 4 0.153846153846154 0.0103896103896104
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.0307412160109098 3083 41 15 0.365853658536585 0.0048653908530652
GO:BP GO:0007165 signal transduction 0.0307412160109098 6309 46 26 0.565217391304348 0.00412109684577588
GO:BP GO:0018212 peptidyl-tyrosine modification 0.0311294509284209 388 26 4 0.153846153846154 0.0103092783505155
GO:BP GO:0010033 response to organic substance 0.0312174554558241 3412 133 39 0.293233082706767 0.0114302461899179
GO:BP GO:0000165 MAPK cascade 0.0312174554558241 935 27 6 0.222222222222222 0.00641711229946524
GO:BP GO:0042770 signal transduction in response to DNA damage 0.0312602060881939 135 122 5 0.040983606557377 0.037037037037037
GO:BP GO:0009888 tissue development 0.0317592711844861 2107 42 12 0.285714285714286 0.0056953013763645
GO:BP GO:0098771 inorganic ion homeostasis 0.0317592711844861 761 125 13 0.104 0.0170827858081472
GO:BP GO:0007155 cell adhesion 0.0317592711844861 1492 81 15 0.185185185185185 0.0100536193029491
GO:BP GO:0051402 neuron apoptotic process 0.0327178613733933 250 68 5 0.0735294117647059 0.02
GO:BP GO:0048513 animal organ development 0.0327178613733933 3672 39 16 0.41025641025641 0.00435729847494553
GO:BP GO:0045667 regulation of osteoblast differentiation 0.0327178613733933 135 36 3 0.0833333333333333 0.0222222222222222
GO:BP GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0327178613733933 110 93 4 0.043010752688172 0.0363636363636364
GO:BP GO:0022610 biological adhesion 0.0327178613733933 1499 81 15 0.185185185185185 0.0100066711140761
GO:BP GO:0006629 lipid metabolic process 0.0327178613733933 1457 117 19 0.162393162393162 0.0130404941660947
GO:BP GO:0006909 phagocytosis 0.0343945599645658 387 45 5 0.111111111111111 0.0129198966408269
GO:BP GO:0006898 receptor-mediated endocytosis 0.0349172250400978 333 32 4 0.125 0.012012012012012
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.0349172250400978 1103 143 18 0.125874125874126 0.0163191296464189
GO:BP GO:0051963 regulation of synapse assembly 0.035121693482289 99 106 4 0.0377358490566038 0.0404040404040404
GO:BP GO:0050778 positive regulation of immune response 0.035121693482289 753 46 7 0.152173913043478 0.00929614873837981
GO:BP GO:0006027 glycosaminoglycan catabolic process 0.0351662023227445 61 83 3 0.036144578313253 0.0491803278688525
GO:BP GO:0010799 regulation of peptidyl-threonine phosphorylation 0.0363618171249347 48 108 3 0.0277777777777778 0.0625
GO:BP GO:0007160 cell-matrix adhesion 0.0363618171249347 235 46 4 0.0869565217391304 0.0170212765957447
GO:BP GO:0055072 iron ion homeostasis 0.036561353126661 86 125 4 0.032 0.0465116279069767
GO:BP GO:0050730 regulation of peptidyl-tyrosine phosphorylation 0.0371859519272379 269 20 3 0.15 0.0111524163568773
GO:BP GO:0071902 positive regulation of protein serine/threonine kinase activity 0.0371859519272379 316 57 5 0.087719298245614 0.0158227848101266
GO:BP GO:0006869 lipid transport 0.0371859519272379 480 113 9 0.079646017699115 0.01875
GO:BP GO:0030335 positive regulation of cell migration 0.0371859519272379 567 133 11 0.0827067669172932 0.0194003527336861
GO:BP GO:0030198 extracellular matrix organization 0.0374104105050636 401 14 3 0.214285714285714 0.00748129675810474
GO:BP GO:0045229 external encapsulating structure organization 0.0374104105050636 404 14 3 0.214285714285714 0.00742574257425743
GO:BP GO:0006635 fatty acid beta-oxidation 0.0374104105050636 76 70 3 0.0428571428571429 0.0394736842105263
GO:BP GO:0043062 extracellular structure organization 0.0374104105050636 402 14 3 0.214285714285714 0.00746268656716418
GO:BP GO:0099054 presynapse assembly 0.0374104105050636 51 106 3 0.0283018867924528 0.0588235294117647
GO:BP GO:0002694 regulation of leukocyte activation 0.0374104105050636 610 143 12 0.0839160839160839 0.019672131147541
GO:BP GO:0009062 fatty acid catabolic process 0.0375718080928174 107 104 4 0.0384615384615385 0.0373831775700935
GO:BP GO:0019395 fatty acid oxidation 0.0385882348482053 108 104 4 0.0384615384615385 0.037037037037037
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.0389404119726562 1042 143 17 0.118881118881119 0.0163147792706334
GO:BP GO:0006026 aminoglycan catabolic process 0.0390649563286292 67 83 3 0.036144578313253 0.0447761194029851
GO:BP GO:0080135 regulation of cellular response to stress 0.0390649563286292 725 122 12 0.0983606557377049 0.016551724137931
GO:BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 0.0390649563286292 167 68 4 0.0588235294117647 0.0239520958083832
GO:BP GO:0007586 digestion 0.0390649563286292 141 131 5 0.0381679389312977 0.0354609929078014
GO:BP GO:0051179 localization 0.0391587098988566 6901 20 14 0.7 0.00202869149398638
GO:BP GO:0043010 camera-type eye development 0.0391587098988566 331 108 7 0.0648148148148148 0.0211480362537764
GO:BP GO:0045944 positive regulation of transcription by RNA polymerase II 0.0391587098988566 1197 48 9 0.1875 0.0075187969924812
GO:BP GO:0048812 neuron projection morphogenesis 0.0391587098988566 664 117 11 0.094017094017094 0.016566265060241
GO:BP GO:1901700 response to oxygen-containing compound 0.0391587098988566 1739 28 8 0.285714285714286 0.00460034502587694
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.0391587098988566 3274 41 15 0.365853658536585 0.00458155161881491
GO:BP GO:0050801 ion homeostasis 0.0391587098988566 808 125 13 0.104 0.0160891089108911
GO:BP GO:0099172 presynapse organization 0.0392273144729218 54 106 3 0.0283018867924528 0.0555555555555556
GO:BP GO:0048704 embryonic skeletal system morphogenesis 0.0392699816214078 94 61 3 0.0491803278688525 0.0319148936170213
GO:BP GO:0048662 negative regulation of smooth muscle cell proliferation 0.0393194461997314 70 82 3 0.0365853658536585 0.0428571428571429
GO:BP GO:0016042 lipid catabolic process 0.0396350910986988 349 104 7 0.0673076923076923 0.0200573065902579
GO:BP GO:0034440 lipid oxidation 0.040026566004393 113 104 4 0.0384615384615385 0.0353982300884956
GO:BP GO:0010952 positive regulation of peptidase activity 0.040026566004393 205 133 6 0.0451127819548872 0.0292682926829268
GO:BP GO:0034599 cellular response to oxidative stress 0.0402984451107931 316 19 3 0.157894736842105 0.00949367088607595
GO:BP GO:0010876 lipid localization 0.0403481439585735 530 127 10 0.078740157480315 0.0188679245283019
GO:BP GO:2000147 positive regulation of cell motility 0.0408155573808609 591 133 11 0.0827067669172932 0.0186125211505922
GO:BP GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 0.0411992194039624 92 130 4 0.0307692307692308 0.0434782608695652
GO:BP GO:0048705 skeletal system morphogenesis 0.041502451614825 226 86 5 0.0581395348837209 0.0221238938053097
GO:BP GO:0007623 circadian rhythm 0.0417866940071916 219 127 6 0.047244094488189 0.0273972602739726
GO:BP GO:0030099 myeloid cell differentiation 0.0420096446839081 428 134 9 0.0671641791044776 0.0210280373831776
GO:BP GO:0009611 response to wounding 0.0426074535506509 674 19 4 0.210526315789474 0.00593471810089021
GO:BP GO:0030030 cell projection organization 0.0430696145561088 1609 19 6 0.315789473684211 0.00372902423865755
GO:BP GO:0002684 positive regulation of immune system process 0.0439706477701879 1065 46 8 0.173913043478261 0.00751173708920188
GO:BP GO:0051272 positive regulation of cellular component movement 0.0440028208055369 604 133 11 0.0827067669172932 0.0182119205298013
GO:BP GO:0051965 positive regulation of synapse assembly 0.0440642036282856 59 106 3 0.0283018867924528 0.0508474576271186
GO:BP GO:0060042 retina morphogenesis in camera-type eye 0.0441405263250484 62 101 3 0.0297029702970297 0.0483870967741935
GO:BP GO:0042981 regulation of apoptotic process 0.0443557221301705 1549 26 7 0.269230769230769 0.00451904454486766
GO:BP GO:0040017 positive regulation of locomotion 0.0443789312262253 606 133 11 0.0827067669172932 0.0181518151815182
GO:BP GO:0071310 cellular response to organic substance 0.0454553879309765 2776 138 33 0.239130434782609 0.0118876080691643
GO:BP GO:0001754 eye photoreceptor cell differentiation 0.0454553879309765 48 133 3 0.0225563909774436 0.0625
GO:BP GO:0050865 regulation of cell activation 0.0460562188439489 655 45 6 0.133333333333333 0.00916030534351145
GO:BP GO:0007507 heart development 0.0461321764405882 578 36 5 0.138888888888889 0.00865051903114187
GO:BP GO:0032501 multicellular organismal process 0.0463890740200918 7946 112 63 0.5625 0.00792851749307828
GO:BP GO:0009952 anterior/posterior pattern specification 0.0465588120911504 211 61 4 0.0655737704918033 0.018957345971564
GO:BP GO:0001501 skeletal system development 0.0465959527469347 504 97 8 0.0824742268041237 0.0158730158730159
GO:BP GO:0055080 cation homeostasis 0.0468295421704513 750 125 12 0.096 0.016
GO:BP GO:0043410 positive regulation of MAPK cascade 0.0468382528813258 539 39 5 0.128205128205128 0.00927643784786642
GO:BP GO:0043406 positive regulation of MAP kinase activity 0.0473770436933863 234 56 4 0.0714285714285714 0.0170940170940171
GO:BP GO:0009967 positive regulation of signal transduction 0.0473770436933863 1598 39 9 0.230769230769231 0.00563204005006258
GO:BP GO:0048511 rhythmic process 0.0475203315768774 307 127 7 0.0551181102362205 0.0228013029315961
GO:BP GO:0031401 positive regulation of protein modification process 0.0478013305979969 1074 57 9 0.157894736842105 0.00837988826815642
GO:BP GO:0002682 regulation of immune system process 0.0480981263935155 1617 60 12 0.2 0.00742115027829314
GO:BP GO:0062197 cellular response to chemical stress 0.0486693542522087 365 19 3 0.157894736842105 0.00821917808219178
GO:BP GO:0043085 positive regulation of catalytic activity 0.049324565639785 1418 60 11 0.183333333333333 0.0077574047954866
GO:BP GO:0006066 alcohol metabolic process 0.0498303824551694 382 104 7 0.0673076923076923 0.0183246073298429
GO:BP GO:0055065 metal ion homeostasis 0.0498303824551694 667 125 11 0.088 0.0164917541229385
GO:BP GO:0048869 cellular developmental process 0.0499941889683481 4428 30 14 0.466666666666667 0.0031616982836495
GO:BP GO:0030334 regulation of cell migration 0.0499941889683481 999 133 15 0.112781954887218 0.015015015015015
GO:BP GO:0033554 cellular response to stress 0.0499941889683481 2111 36 10 0.277777777777778 0.00473709142586452
GO:BP GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 0.0499941889683481 81 85 3 0.0352941176470588 0.037037037037037
GO:BP GO:0015718 monocarboxylic acid transport 0.0499941889683481 189 113 5 0.0442477876106195 0.0264550264550265
GO:CC GO:0070062 extracellular exosome 5.0144257447237e-08 2176 94 34 0.361702127659574 0.015625
GO:CC GO:0042571 immunoglobulin complex, circulating 5.0144257447237e-08 77 94 9 0.0957446808510638 0.116883116883117
GO:CC GO:0071751 secretory IgA immunoglobulin complex 5.0144257447237e-08 5 9 3 0.333333333333333 0.6
GO:CC GO:0071749 polymeric IgA immunoglobulin complex 5.0144257447237e-08 5 9 3 0.333333333333333 0.6
GO:CC GO:0071746 IgA immunoglobulin complex, circulating 5.0144257447237e-08 5 9 3 0.333333333333333 0.6
GO:CC GO:0071745 IgA immunoglobulin complex 5.0144257447237e-08 5 9 3 0.333333333333333 0.6
GO:CC GO:1903561 extracellular vesicle 5.14043502384178e-08 2261 94 34 0.361702127659574 0.0150375939849624
GO:CC GO:0043230 extracellular organelle 5.14043502384178e-08 2263 94 34 0.361702127659574 0.0150243040212108
GO:CC GO:0005615 extracellular space 4.56268701400284e-06 3594 97 41 0.422680412371134 0.0114079020589872
GO:CC GO:0019814 immunoglobulin complex 5.0531149543103e-06 167 45 7 0.155555555555556 0.0419161676646707
GO:CC GO:0072562 blood microparticle 1.74436706018141e-05 140 94 8 0.0851063829787234 0.0571428571428571
GO:CC GO:0030141 secretory granule 4.27180516615462e-05 851 15 7 0.466666666666667 0.0082256169212691
GO:CC GO:0005576 extracellular region 8.57569959369327e-05 4567 97 44 0.45360824742268 0.00963433326034596
GO:CC GO:0009986 cell surface 0.000126430920677694 899 45 11 0.244444444444444 0.0122358175750834
GO:CC GO:0099503 secretory vesicle 0.000126430920677694 1020 15 7 0.466666666666667 0.00686274509803922
GO:CC GO:0031982 vesicle 0.000156814045727855 4055 84 36 0.428571428571429 0.00887792848335388
GO:CC GO:0031253 cell projection membrane 0.000567315182847679 343 51 7 0.137254901960784 0.0204081632653061
GO:CC GO:0009897 external side of plasma membrane 0.000711846017236337 408 45 7 0.155555555555556 0.017156862745098
GO:CC GO:0005796 Golgi lumen 0.00145382244978566 99 46 4 0.0869565217391304 0.0404040404040404
GO:CC GO:0098858 actin-based cell projection 0.00190924659037048 220 23 4 0.173913043478261 0.0181818181818182
GO:CC GO:0043235 receptor complex 0.00239652313324192 522 20 5 0.25 0.00957854406130268
GO:CC GO:0098590 plasma membrane region 0.00356580938884249 1240 57 12 0.210526315789474 0.00967741935483871
GO:CC GO:0031256 leading edge membrane 0.00450658498171532 175 37 4 0.108108108108108 0.0228571428571429
GO:CC GO:0005794 Golgi apparatus 0.00450658498171532 1623 141 25 0.177304964539007 0.0154035736290819
GO:CC GO:0005737 cytoplasm 0.00505488017571697 11911 143 109 0.762237762237762 0.0091512047687012
GO:CC GO:0045177 apical part of cell 0.0064843797863856 431 103 9 0.087378640776699 0.0208816705336427
GO:CC GO:0031252 cell leading edge 0.0064843797863856 422 47 6 0.127659574468085 0.014218009478673
GO:CC GO:0098552 side of membrane 0.0064843797863856 619 45 7 0.155555555555556 0.0113085621970921
GO:CC GO:0030667 secretory granule membrane 0.00649370188668079 303 11 3 0.272727272727273 0.0099009900990099
GO:CC GO:0016324 apical plasma membrane 0.00803406538552471 361 103 8 0.0776699029126214 0.0221606648199446
GO:CC GO:0097708 intracellular vesicle 0.00914415730091555 2428 22 9 0.409090909090909 0.00370675453047776
GO:CC GO:0031410 cytoplasmic vesicle 0.00914415730091555 2424 22 9 0.409090909090909 0.00371287128712871
GO:CC GO:0012505 endomembrane system 0.0125329588739138 4640 125 46 0.368 0.00991379310344828
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0159998673908961 324 15 3 0.2 0.00925925925925926
GO:CC GO:0001725 stress fiber 0.0159998673908961 68 69 3 0.0434782608695652 0.0441176470588235
GO:CC GO:0097517 contractile actin filament bundle 0.0159998673908961 68 69 3 0.0434782608695652 0.0441176470588235
GO:CC GO:0034774 secretory granule lumen 0.0159998673908961 320 15 3 0.2 0.009375
GO:CC GO:0031983 vesicle lumen 0.0159998673908961 326 15 3 0.2 0.00920245398773006
GO:CC GO:0035577 azurophil granule membrane 0.0164853862612243 57 84 3 0.0357142857142857 0.0526315789473684
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.0176227560910685 779 143 14 0.0979020979020979 0.0179717586649551
GO:CC GO:0016021 integral component of membrane 0.0176227560910685 5711 84 38 0.452380952380952 0.0066538259499212
GO:CC GO:0042641 actomyosin 0.0184749817553168 77 69 3 0.0434782608695652 0.038961038961039
GO:CC GO:0005829 cytosol 0.0184749817553168 5303 135 53 0.392592592592593 0.00999434282481614
GO:CC GO:0005802 trans-Golgi network 0.0184749817553168 250 22 3 0.136363636363636 0.012
GO:CC GO:0012506 vesicle membrane 0.0184749817553168 800 143 14 0.0979020979020979 0.0175
GO:CC GO:0032432 actin filament bundle 0.0184749817553168 76 69 3 0.0434782608695652 0.0394736842105263
GO:CC GO:0071944 cell periphery 0.0189727460008939 6169 57 29 0.508771929824561 0.00470092397471227
GO:CC GO:0031224 intrinsic component of membrane 0.023162139169644 5868 84 38 0.452380952380952 0.00647580095432856
GO:CC GO:0005886 plasma membrane 0.0231884884419693 5681 57 27 0.473684210526316 0.00475268438655166
GO:CC GO:0001726 ruffle 0.0231884884419693 179 69 4 0.0579710144927536 0.0223463687150838
GO:CC GO:0005766 primary lysosome 0.0258798757795728 154 84 4 0.0476190476190476 0.025974025974026
GO:CC GO:0070161 anchoring junction 0.0258798757795728 836 87 10 0.114942528735632 0.0119617224880383
GO:CC GO:0042582 azurophil granule 0.0258798757795728 154 84 4 0.0476190476190476 0.025974025974026
GO:CC GO:0045334 clathrin-coated endocytic vesicle 0.0350008017780288 54 138 3 0.0217391304347826 0.0555555555555556
GO:CC GO:0005912 adherens junction 0.0391971015823499 173 87 4 0.0459770114942529 0.023121387283237
GO:CC GO:0030665 clathrin-coated vesicle membrane 0.041893856127662 114 138 4 0.0289855072463768 0.0350877192982456
GO:CC GO:0030425 dendrite 0.0442688703992861 638 14 3 0.214285714285714 0.00470219435736677
GO:CC GO:0097447 dendritic tree 0.0442688703992861 640 14 3 0.214285714285714 0.0046875
GO:MF GO:0034987 immunoglobulin receptor binding 3.30396099014469e-06 79 94 8 0.0851063829787234 0.10126582278481
GO:MF GO:0042834 peptidoglycan binding 9.68634813867478e-05 18 63 4 0.0634920634920635 0.222222222222222
GO:MF GO:0005539 glycosaminoglycan binding 0.00010926800394914 238 14 5 0.357142857142857 0.0210084033613445
GO:MF GO:0003823 antigen binding 0.000232879851689838 163 94 8 0.0851063829787234 0.049079754601227
GO:MF GO:0005102 signaling receptor binding 0.003452890262821 1672 46 14 0.304347826086957 0.00837320574162679
GO:MF GO:0030545 receptor regulator activity 0.0214588676878352 545 14 4 0.285714285714286 0.0073394495412844
GO:MF GO:0030546 signaling receptor activator activity 0.0214588676878352 501 14 4 0.285714285714286 0.00798403193612774
GO:MF GO:0050997 quaternary ammonium group binding 0.0214588676878352 31 105 3 0.0285714285714286 0.0967741935483871
GO:MF GO:0140375 immune receptor activity 0.0214588676878352 133 20 3 0.15 0.0225563909774436
GO:MF GO:0031210 phosphatidylcholine binding 0.0214588676878352 31 105 3 0.0285714285714286 0.0967741935483871
GO:MF GO:0048018 receptor ligand activity 0.0260262677472901 494 8 3 0.375 0.00607287449392713
GO:MF GO:0046983 protein dimerization activity 0.0265771771274844 1069 140 18 0.128571428571429 0.0168381665107577
GO:MF GO:0050839 cell adhesion molecule binding 0.0328983543484101 546 75 8 0.106666666666667 0.0146520146520147
GO:MF GO:0008083 growth factor activity 0.0338794689801234 163 28 3 0.107142857142857 0.0184049079754601
GO:MF GO:0042803 protein homodimerization activity 0.0338794689801234 676 140 13 0.0928571428571429 0.0192307692307692
GO:MF GO:0042802 identical protein binding 0.0338794689801234 2067 27 9 0.333333333333333 0.00435413642960813
GO:MF GO:0046914 transition metal ion binding 0.0393754076543523 1111 24 6 0.25 0.0054005400540054
GO:MF GO:0050660 flavin adenine dinucleotide binding 0.0496802228306242 83 70 3 0.0428571428571429 0.036144578313253
REAC REAC:R-HSA-202733 Cell surface interactions at the vascular wall 0.000611670941367316 190 45 8 0.177777777777778 0.0421052631578947
REAC REAC:R-HSA-2168880 Scavenging of heme from plasma 0.012251764747738 67 32 4 0.125 0.0597014925373134
REAC REAC:R-HSA-173623 Classical antibody-mediated complement activation 0.021236984651198 61 94 5 0.0531914893617021 0.0819672131147541
REAC REAC:R-HSA-77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 0.021236984651198 11 109 3 0.0275229357798165 0.272727272727273
REAC REAC:R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.021236984651198 95 32 4 0.125 0.0421052631578947
REAC REAC:R-HSA-166786 Creation of C4 and C2 activators 0.0221439005826204 68 94 5 0.0531914893617021 0.0735294117647059
REAC REAC:R-HSA-2029485 Role of phospholipids in phagocytosis 0.0221439005826204 81 117 6 0.0512820512820513 0.0740740740740741
REAC REAC:R-HSA-2029481 FCGR activation 0.0221439005826204 67 94 5 0.0531914893617021 0.0746268656716418
REAC REAC:R-HSA-109582 Hemostasis 0.0285935442262903 657 32 8 0.25 0.0121765601217656
REAC REAC:R-HSA-166663 Initial triggering of complement 0.0285935442262903 76 94 5 0.0531914893617021 0.0657894736842105
REAC REAC:R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.0285935442262903 37 109 4 0.036697247706422 0.108108108108108
REAC REAC:R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 0.0387700845060974 85 143 6 0.041958041958042 0.0705882352941176
REAC REAC:R-HSA-525793 Myogenesis 0.0387700845060974 28 73 3 0.0410958904109589 0.107142857142857
REAC REAC:R-HSA-166520 Signaling by NTRKs 0.0441667737329185 130 133 7 0.0526315789473684 0.0538461538461538
REAC REAC:R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.0463493902715393 93 94 5 0.0531914893617021 0.0537634408602151

pEpiTp07 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp07
Possible regulators of activation of pEpiTp07 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.