pP07 program activity among Plasma cells

Activation of pP07
pP07 gene program activation in Plasma cells.
Gene program activation of pP07 by different cell subtypes
pP07 gene program activation among cells of different subtypes (Plasma cells).

pP07 top program genes

Top genes of pP07 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pP07 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pP07
pP07 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:725 P2X7 receptor signalling complex 0.000291872068450452 12 10 3 0.3 0.25
GO:BP GO:0006986 response to unfolded protein 2.3196506757663e-19 184 14 12 0.857142857142857 0.0652173913043478
GO:BP GO:0035966 response to topologically incorrect protein 4.39849957094915e-19 205 14 12 0.857142857142857 0.0585365853658537
GO:BP GO:0006457 protein folding 9.21199369576762e-19 225 14 12 0.857142857142857 0.0533333333333333
GO:BP GO:0009408 response to heat 5.06671536444612e-18 159 19 12 0.631578947368421 0.0754716981132075
GO:BP GO:0006458 'de novo' protein folding 2.57853605646474e-17 40 19 9 0.473684210526316 0.225
GO:BP GO:0009266 response to temperature stimulus 2.57853605646474e-17 228 63 18 0.285714285714286 0.0789473684210526
GO:BP GO:0034605 cellular response to heat 7.70605022177344e-16 118 17 10 0.588235294117647 0.0847457627118644
GO:BP GO:0051085 chaperone cofactor-dependent protein refolding 7.92940065033315e-16 31 19 8 0.421052631578947 0.258064516129032
GO:BP GO:0061077 chaperone-mediated protein folding 9.28602376805806e-16 61 19 9 0.473684210526316 0.147540983606557
GO:BP GO:0051084 'de novo' posttranslational protein folding 2.42674024883056e-15 36 19 8 0.421052631578947 0.222222222222222
GO:BP GO:1900034 regulation of cellular response to heat 6.01869826902148e-13 79 17 8 0.470588235294118 0.10126582278481
GO:BP GO:0042026 protein refolding 1.5836021656092e-12 23 14 6 0.428571428571429 0.260869565217391
GO:BP GO:0009628 response to abiotic stimulus 2.84775141503104e-11 1261 24 16 0.666666666666667 0.0126883425852498
GO:BP GO:0033554 cellular response to stress 2.11523844805594e-10 2111 17 15 0.882352941176471 0.00710563713879678
GO:BP GO:0006950 response to stress 2.11523844805594e-10 4170 124 65 0.524193548387097 0.0155875299760192
GO:BP GO:0080135 regulation of cellular response to stress 7.52238912841987e-10 725 17 11 0.647058823529412 0.0151724137931034
GO:BP GO:0070841 inclusion body assembly 3.23298779763702e-08 24 63 6 0.0952380952380952 0.25
GO:BP GO:0090084 negative regulation of inclusion body assembly 3.38128352602337e-08 11 63 5 0.0793650793650794 0.454545454545455
GO:BP GO:0080134 regulation of response to stress 4.3158153895113e-08 1443 17 12 0.705882352941177 0.00831600831600832
GO:BP GO:0051131 chaperone-mediated protein complex assembly 1.0158754089422e-07 21 12 4 0.333333333333333 0.19047619047619
GO:BP GO:0090083 regulation of inclusion body assembly 3.82016283102937e-07 17 63 5 0.0793650793650794 0.294117647058824
GO:BP GO:0008219 cell death 4.98810619687378e-07 2292 45 22 0.488888888888889 0.00959860383944154
GO:BP GO:0031396 regulation of protein ubiquitination 5.0159859772854e-07 211 13 6 0.461538461538462 0.028436018957346
GO:BP GO:0010033 response to organic substance 5.48839742410677e-07 3412 14 13 0.928571428571429 0.00381008206330598
GO:BP GO:0010941 regulation of cell death 5.76896411337424e-07 1720 44 19 0.431818181818182 0.011046511627907
GO:BP GO:0042981 regulation of apoptotic process 7.65198670815367e-07 1549 44 18 0.409090909090909 0.0116204002582311
GO:BP GO:0012501 programmed cell death 7.87689613249183e-07 2143 45 21 0.466666666666667 0.00979934671021932
GO:BP GO:0042221 response to chemical 8.36306238719963e-07 4781 14 14 1 0.00292825768667643
GO:BP GO:0006915 apoptotic process 8.36306238719963e-07 1990 44 20 0.454545454545455 0.0100502512562814
GO:BP GO:1903320 regulation of protein modification by small protein conjugation or removal 8.95356522447459e-07 243 13 6 0.461538461538462 0.0246913580246914
GO:BP GO:0043067 regulation of programmed cell death 8.95356522447459e-07 1582 44 18 0.409090909090909 0.011378002528445
GO:BP GO:0050821 protein stabilization 1.20141888461311e-06 193 42 8 0.19047619047619 0.0414507772020725
GO:BP GO:0031647 regulation of protein stability 1.56383419904846e-06 300 12 6 0.5 0.02
GO:BP GO:0034620 cellular response to unfolded protein 1.85102502406757e-06 149 108 10 0.0925925925925926 0.0671140939597315
GO:BP GO:0016032 viral process 1.88506616907384e-06 942 12 8 0.666666666666667 0.00849256900212314
GO:BP GO:0044403 biological process involved in symbiotic interaction 2.9488430180723e-06 1001 12 8 0.666666666666667 0.00799200799200799
GO:BP GO:0060548 negative regulation of cell death 3.67792681783578e-06 1038 42 14 0.333333333333333 0.0134874759152216
GO:BP GO:0035967 cellular response to topologically incorrect protein 4.23180948183333e-06 168 57 8 0.140350877192982 0.0476190476190476
GO:BP GO:0043085 positive regulation of catalytic activity 4.46115071685237e-06 1418 24 12 0.5 0.00846262341325811
GO:BP GO:0031329 regulation of cellular catabolic process 4.55718916634025e-06 866 10 7 0.7 0.00808314087759815
GO:BP GO:0044093 positive regulation of molecular function 4.77962980294485e-06 1771 24 13 0.541666666666667 0.00734048560135517
GO:BP GO:1903362 regulation of cellular protein catabolic process 4.899451022577e-06 257 9 5 0.555555555555556 0.0194552529182879
GO:BP GO:0043066 negative regulation of apoptotic process 6.46470605687368e-06 921 42 13 0.30952380952381 0.0141150922909881
GO:BP GO:0043069 negative regulation of programmed cell death 8.3157579900824e-06 943 42 13 0.30952380952381 0.0137857900318134
GO:BP GO:0050790 regulation of catalytic activity 8.75552436165495e-06 2545 25 15 0.6 0.00589390962671906
GO:BP GO:0065009 regulation of molecular function 9.42517645370357e-06 3221 29 18 0.620689655172414 0.0055883266066439
GO:BP GO:0009894 regulation of catabolic process 1.22624489969926e-05 1033 10 7 0.7 0.00677637947725073
GO:BP GO:0001775 cell activation 1.43790433492359e-05 1495 14 9 0.642857142857143 0.00602006688963211
GO:BP GO:0002274 myeloid leukocyte activation 1.44886806052544e-05 667 14 7 0.5 0.0104947526236882
GO:BP GO:0048583 regulation of response to stimulus 1.70057544369307e-05 4278 13 12 0.923076923076923 0.00280504908835905
GO:BP GO:0002366 leukocyte activation involved in immune response 2.19779028860481e-05 717 14 7 0.5 0.0097629009762901
GO:BP GO:0002263 cell activation involved in immune response 2.2422126402314e-05 721 14 7 0.5 0.00970873786407767
GO:BP GO:0032273 positive regulation of protein polymerization 2.46347393943259e-05 141 3 3 1 0.0212765957446809
GO:BP GO:1903364 positive regulation of cellular protein catabolic process 3.03053409453927e-05 154 3 3 1 0.0194805194805195
GO:BP GO:0042176 regulation of protein catabolic process 3.03053409453927e-05 401 9 5 0.555555555555556 0.0124688279301746
GO:BP GO:0019058 viral life cycle 3.12008912131264e-05 353 10 5 0.5 0.0141643059490085
GO:BP GO:0044265 cellular macromolecule catabolic process 3.18230065630956e-05 1231 10 7 0.7 0.00568643379366369
GO:BP GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway 3.90403663774441e-05 40 9 3 0.333333333333333 0.075
GO:BP GO:0097190 apoptotic signaling pathway 3.90403663774441e-05 600 42 10 0.238095238095238 0.0166666666666667
GO:BP GO:0043312 neutrophil degranulation 3.97920511990463e-05 482 14 6 0.428571428571429 0.012448132780083
GO:BP GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 4.01652276800004e-05 41 9 3 0.333333333333333 0.0731707317073171
GO:BP GO:0002283 neutrophil activation involved in immune response 4.01652276800004e-05 485 14 6 0.428571428571429 0.0123711340206186
GO:BP GO:0006402 mRNA catabolic process 4.25646993556308e-05 384 10 5 0.5 0.0130208333333333
GO:BP GO:0001817 regulation of cytokine production 4.32205142043505e-05 806 6 5 0.833333333333333 0.00620347394540943
GO:BP GO:0002446 neutrophil mediated immunity 4.36000761847448e-05 497 14 6 0.428571428571429 0.0120724346076459
GO:BP GO:0042119 neutrophil activation 4.36000761847448e-05 498 14 6 0.428571428571429 0.0120481927710843
GO:BP GO:0036230 granulocyte activation 4.61333490014588e-05 504 14 6 0.428571428571429 0.0119047619047619
GO:BP GO:0001816 cytokine production 5.09808829887222e-05 844 6 5 0.833333333333333 0.00592417061611374
GO:BP GO:0061136 regulation of proteasomal protein catabolic process 5.23501096769213e-05 186 9 4 0.444444444444444 0.021505376344086
GO:BP GO:0019221 cytokine-mediated signaling pathway 5.51610309681041e-05 810 10 6 0.6 0.00740740740740741
GO:BP GO:0006401 RNA catabolic process 5.83290904468584e-05 424 10 5 0.5 0.0117924528301887
GO:BP GO:0043299 leukocyte degranulation 5.83290904468584e-05 535 14 6 0.428571428571429 0.011214953271028
GO:BP GO:0002443 leukocyte mediated immunity 5.83290904468584e-05 877 14 7 0.5 0.00798175598631699
GO:BP GO:0072594 establishment of protein localization to organelle 5.83290904468584e-05 584 13 6 0.461538461538462 0.0102739726027397
GO:BP GO:0030162 regulation of proteolysis 6.01858112902836e-05 752 29 9 0.310344827586207 0.011968085106383
GO:BP GO:0045321 leukocyte activation 6.053450457037e-05 1332 14 8 0.571428571428571 0.00600600600600601
GO:BP GO:0002275 myeloid cell activation involved in immune response 6.36842600814183e-05 547 14 6 0.428571428571429 0.0109689213893967
GO:BP GO:0098754 detoxification 6.36842600814183e-05 134 112 8 0.0714285714285714 0.0597014925373134
GO:BP GO:0002444 myeloid leukocyte mediated immunity 6.46212843652178e-05 551 14 6 0.428571428571429 0.0108892921960073
GO:BP GO:0001819 positive regulation of cytokine production 6.46212843652178e-05 452 5 4 0.8 0.00884955752212389
GO:BP GO:0070887 cellular response to chemical stimulus 6.92304926955493e-05 3393 14 11 0.785714285714286 0.00324196875921014
GO:BP GO:0071345 cellular response to cytokine stimulus 7.12969572026301e-05 1132 12 7 0.583333333333333 0.00618374558303887
GO:BP GO:0032271 regulation of protein polymerization 7.12969572026301e-05 236 3 3 1 0.0127118644067797
GO:BP GO:0009057 macromolecule catabolic process 7.12969572026301e-05 1468 10 7 0.7 0.00476839237057221
GO:BP GO:0045732 positive regulation of protein catabolic process 7.12969572026301e-05 237 3 3 1 0.0126582278481013
GO:BP GO:0043488 regulation of mRNA stability 7.61783823403343e-05 191 10 4 0.4 0.0209424083769634
GO:BP GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 8.0128765087528e-05 221 9 4 0.444444444444444 0.0180995475113122
GO:BP GO:0009636 response to toxic substance 8.20767577149171e-05 243 112 10 0.0892857142857143 0.0411522633744856
GO:BP GO:0043487 regulation of RNA stability 8.84750830812572e-05 201 10 4 0.4 0.0199004975124378
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 8.84750830812572e-05 3483 10 9 0.9 0.00258397932816537
GO:BP GO:0006886 intracellular protein transport 8.9158554016927e-05 1186 12 7 0.583333333333333 0.00590219224283305
GO:BP GO:0031334 positive regulation of protein-containing complex assembly 8.91912530496824e-05 263 3 3 1 0.0114068441064639
GO:BP GO:0051641 cellular localization 9.17111536144199e-05 3541 14 11 0.785714285714286 0.00310646709968935
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.000101547033247941 363 13 5 0.384615384615385 0.0137741046831956
GO:BP GO:0062197 cellular response to chemical stress 0.00010335649752432 365 13 5 0.384615384615385 0.0136986301369863
GO:BP GO:0061013 regulation of mRNA catabolic process 0.000103872106924449 213 10 4 0.4 0.0187793427230047
GO:BP GO:0034097 response to cytokine 0.000104358832831577 1226 12 7 0.583333333333333 0.00570962479608483
GO:BP GO:0071310 cellular response to organic substance 0.000107202173204922 2776 14 10 0.714285714285714 0.00360230547550432
GO:BP GO:0030163 protein catabolic process 0.000113524836934023 974 10 6 0.6 0.00616016427104723
GO:BP GO:0051649 establishment of localization in cell 0.000118191310368622 2813 14 10 0.714285714285714 0.00355492356914326
GO:BP GO:0051345 positive regulation of hydrolase activity 0.000118191310368622 783 98 16 0.163265306122449 0.0204342273307791
GO:BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 0.000124562730721156 167 13 4 0.307692307692308 0.0239520958083832
GO:BP GO:0051258 protein polymerization 0.000125038630107354 305 3 3 1 0.00983606557377049
GO:BP GO:0016192 vesicle-mediated transport 0.000134213141411318 2180 11 8 0.727272727272727 0.0036697247706422
GO:BP GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 0.000134803012450238 73 9 3 0.333333333333333 0.0410958904109589
GO:BP GO:0097191 extrinsic apoptotic signaling pathway 0.000142082217398297 223 104 9 0.0865384615384615 0.0403587443946188
GO:BP GO:2000145 regulation of cell motility 0.00015064106522095 1061 120 21 0.175 0.0197926484448633
GO:BP GO:0009893 positive regulation of metabolic process 0.000153164116227461 3783 10 9 0.9 0.00237906423473434
GO:BP GO:0061684 chaperone-mediated autophagy 0.000158618156517647 16 42 3 0.0714285714285714 0.1875
GO:BP GO:0034655 nucleobase-containing compound catabolic process 0.000161632945279966 567 10 5 0.5 0.00881834215167548
GO:BP GO:1902531 regulation of intracellular signal transduction 0.000164646889219198 1842 16 9 0.5625 0.00488599348534202
GO:BP GO:0017038 protein import 0.000176261038632827 205 42 6 0.142857142857143 0.0292682926829268
GO:BP GO:0006979 response to oxidative stress 0.000180411115272578 466 12 5 0.416666666666667 0.0107296137339056
GO:BP GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 0.000185416018929365 134 6 3 0.5 0.0223880597014925
GO:BP GO:0016049 cell growth 0.000185669580858287 495 6 4 0.666666666666667 0.00808080808080808
GO:BP GO:0021954 central nervous system neuron development 0.000185669580858287 84 9 3 0.333333333333333 0.0357142857142857
GO:BP GO:0002221 pattern recognition receptor signaling pathway 0.000195842419277688 213 12 4 0.333333333333333 0.0187793427230047
GO:BP GO:2000147 positive regulation of cell motility 0.000195842419277688 591 120 15 0.125 0.0253807106598985
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.000197435543197512 2541 13 9 0.692307692307692 0.00354191263282172
GO:BP GO:0046700 heterocycle catabolic process 0.000197538977220986 602 10 5 0.5 0.00830564784053156
GO:BP GO:0044087 regulation of cellular component biogenesis 0.000198877851213216 990 4 4 1 0.00404040404040404
GO:BP GO:1903426 regulation of reactive oxygen species biosynthetic process 0.000198877851213216 111 22 4 0.181818181818182 0.036036036036036
GO:BP GO:0044270 cellular nitrogen compound catabolic process 0.00020002190148519 608 10 5 0.5 0.00822368421052632
GO:BP GO:0048522 positive regulation of cellular process 0.000209317025240856 5757 13 12 0.923076923076923 0.00208441896821261
GO:BP GO:0031331 positive regulation of cellular catabolic process 0.000217824587362369 393 3 3 1 0.00763358778625954
GO:BP GO:0019439 aromatic compound catabolic process 0.000220574975435543 623 10 5 0.5 0.00802568218298555
GO:BP GO:0040012 regulation of locomotion 0.000225738974716631 1104 120 21 0.175 0.0190217391304348
GO:BP GO:0051272 positive regulation of cellular component movement 0.000226043907409403 604 120 15 0.125 0.0248344370860927
GO:BP GO:0040017 positive regulation of locomotion 0.000233500549699817 606 120 15 0.125 0.0247524752475248
GO:BP GO:0009409 response to cold 0.000250159505690978 48 54 4 0.0740740740740741 0.0833333333333333
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 0.000250159505690978 4102 10 9 0.9 0.00219405168210629
GO:BP GO:1901361 organic cyclic compound catabolic process 0.000254153295815616 651 10 5 0.5 0.00768049155145929
GO:BP GO:0015031 protein transport 0.000254153295815616 1929 13 8 0.615384615384615 0.00414722654224987
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.00025551679284857 1477 12 7 0.583333333333333 0.004739336492891
GO:BP GO:2000058 regulation of ubiquitin-dependent protein catabolic process 0.000281367833240395 165 6 3 0.5 0.0181818181818182
GO:BP GO:0045055 regulated exocytosis 0.000281367833240395 785 14 6 0.428571428571429 0.00764331210191083
GO:BP GO:0051246 regulation of protein metabolic process 0.000281473916344392 2704 13 9 0.692307692307692 0.00332840236686391
GO:BP GO:0015833 peptide transport 0.00028757808814356 1971 13 8 0.615384615384615 0.00405885337392187
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.000291234749274943 2719 13 9 0.692307692307692 0.00331004045605002
GO:BP GO:0006810 transport 0.000303481733451928 5224 14 12 0.857142857142857 0.00229709035222052
GO:BP GO:0043254 regulation of protein-containing complex assembly 0.000305187026846215 460 3 3 1 0.00652173913043478
GO:BP GO:2000379 positive regulation of reactive oxygen species metabolic process 0.000305575895220419 107 54 5 0.0925925925925926 0.0467289719626168
GO:BP GO:0007017 microtubule-based process 0.000305821673018498 881 13 6 0.461538461538462 0.00681044267877412
GO:BP GO:0009896 positive regulation of catabolic process 0.000305821673018498 464 3 3 1 0.00646551724137931
GO:BP GO:0042886 amide transport 0.000312627251355036 2007 13 8 0.615384615384615 0.00398604882909816
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.000313792754773212 2255 12 8 0.666666666666667 0.00354767184035477
GO:BP GO:0051270 regulation of cellular component movement 0.000313792754773212 1141 120 21 0.175 0.0184049079754601
GO:BP GO:0032879 regulation of localization 0.000313792754773212 2872 122 38 0.311475409836066 0.0132311977715877
GO:BP GO:0034613 cellular protein localization 0.000313792754773212 2014 13 8 0.615384615384615 0.00397219463753724
GO:BP GO:0016567 protein ubiquitination 0.000313792754773212 892 13 6 0.461538461538462 0.00672645739910314
GO:BP GO:2001234 negative regulation of apoptotic signaling pathway 0.000317357016166591 236 13 4 0.307692307692308 0.0169491525423729
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 0.000317357016166591 111 9 3 0.333333333333333 0.027027027027027
GO:BP GO:0070727 cellular macromolecule localization 0.000317357016166591 2024 13 8 0.615384615384615 0.00395256916996047
GO:BP GO:0051336 regulation of hydrolase activity 0.000322471134926103 1321 121 23 0.190082644628099 0.0174110522331567
GO:BP GO:0051247 positive regulation of protein metabolic process 0.000323730896062693 1564 12 7 0.583333333333333 0.00447570332480818
GO:BP GO:0045184 establishment of protein localization 0.000325012415132117 2035 13 8 0.615384615384615 0.00393120393120393
GO:BP GO:0044257 cellular protein catabolic process 0.000327760999128511 813 9 5 0.555555555555556 0.00615006150061501
GO:BP GO:1903409 reactive oxygen species biosynthetic process 0.000327760999128511 135 22 4 0.181818181818182 0.0296296296296296
GO:BP GO:0001959 regulation of cytokine-mediated signaling pathway 0.000335486498629173 184 6 3 0.5 0.016304347826087
GO:BP GO:0009889 regulation of biosynthetic process 0.000349850008738366 4361 10 9 0.9 0.00206374684705343
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 0.000352914765194871 117 9 3 0.333333333333333 0.0256410256410256
GO:BP GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand 0.000352914765194871 71 42 4 0.0952380952380952 0.0563380281690141
GO:BP GO:0038034 signal transduction in absence of ligand 0.000352914765194871 71 42 4 0.0952380952380952 0.0563380281690141
GO:BP GO:0002252 immune effector process 0.000356171012083191 1309 14 7 0.5 0.0053475935828877
GO:BP GO:0051234 establishment of localization 0.000356171012083191 5372 14 12 0.857142857142857 0.00223380491437081
GO:BP GO:0045926 negative regulation of growth 0.000381651922580362 255 84 8 0.0952380952380952 0.0313725490196078
GO:BP GO:0060759 regulation of response to cytokine stimulus 0.000392521930886308 197 6 3 0.5 0.0152284263959391
GO:BP GO:0031397 negative regulation of protein ubiquitination 0.000403174536840206 83 13 3 0.230769230769231 0.036144578313253
GO:BP GO:0044089 positive regulation of cellular component biogenesis 0.000411825872985138 540 3 3 1 0.00555555555555556
GO:BP GO:0034599 cellular response to oxidative stress 0.000423269559795553 316 11 4 0.363636363636364 0.0126582278481013
GO:BP GO:0032781 positive regulation of ATPase activity 0.00042735827697855 57 19 3 0.157894736842105 0.0526315789473684
GO:BP GO:1903311 regulation of mRNA metabolic process 0.000431830035162813 356 10 4 0.4 0.0112359550561798
GO:BP GO:1901565 organonitrogen compound catabolic process 0.000433992127717102 1358 10 6 0.6 0.00441826215022091
GO:BP GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 0.000437906470714927 129 9 3 0.333333333333333 0.0232558139534884
GO:BP GO:0032446 protein modification by small protein conjugation 0.000441961346966323 973 13 6 0.461538461538462 0.00616649537512847
GO:BP GO:2000377 regulation of reactive oxygen species metabolic process 0.000449370693712585 203 54 6 0.111111111111111 0.0295566502463054
GO:BP GO:0030334 regulation of cell migration 0.000449370693712585 999 120 19 0.158333333333333 0.019019019019019
GO:BP GO:0065003 protein-containing complex assembly 0.000449370693712585 1680 12 7 0.583333333333333 0.00416666666666667
GO:BP GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 0.000451354219714884 132 9 3 0.333333333333333 0.0227272727272727
GO:BP GO:0048518 positive regulation of biological process 0.000451354219714884 6363 13 12 0.923076923076923 0.00188590287600189
GO:BP GO:0007049 cell cycle 0.0004572477593448 1902 11 7 0.636363636363636 0.00368033648790747
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.000458398444744108 1082 29 9 0.310344827586207 0.00831792975970425
GO:BP GO:0006887 exocytosis 0.000466682680467417 904 14 6 0.428571428571429 0.00663716814159292
GO:BP GO:0007586 digestion 0.000466682680467417 141 115 7 0.0608695652173913 0.049645390070922
GO:BP GO:1990169 stress response to copper ion 0.000479066758068609 14 84 3 0.0357142857142857 0.214285714285714
GO:BP GO:0010273 detoxification of copper ion 0.000479066758068609 14 84 3 0.0357142857142857 0.214285714285714
GO:BP GO:0031399 regulation of protein modification process 0.000479066758068609 1671 16 8 0.5 0.00478755236385398
GO:BP GO:0051726 regulation of cell cycle 0.000482808245576662 1236 11 6 0.545454545454545 0.00485436893203883
GO:BP GO:1903428 positive regulation of reactive oxygen species biosynthetic process 0.00048456420385829 62 54 4 0.0740740740740741 0.0645161290322581
GO:BP GO:0034622 cellular protein-containing complex assembly 0.00048456420385829 1107 12 6 0.5 0.00542005420054201
GO:BP GO:0007041 lysosomal transport 0.000492532673753076 111 11 3 0.272727272727273 0.027027027027027
GO:BP GO:0046686 response to cadmium ion 0.000492532673753076 65 104 5 0.0480769230769231 0.0769230769230769
GO:BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 0.00051186282623472 434 9 4 0.444444444444444 0.00921658986175115
GO:BP GO:0033365 protein localization to organelle 0.000515193525524651 1017 13 6 0.461538461538462 0.00589970501474926
GO:BP GO:0030522 intracellular receptor signaling pathway 0.000515697454769569 284 13 4 0.307692307692308 0.0140845070422535
GO:BP GO:0052547 regulation of peptidase activity 0.000519319410121442 467 114 12 0.105263157894737 0.0256959314775161
GO:BP GO:0040007 growth 0.000520538862751428 967 66 13 0.196969696969697 0.0134436401240951
GO:BP GO:1903321 negative regulation of protein modification by small protein conjugation or removal 0.000532801864231105 96 13 3 0.230769230769231 0.03125
GO:BP GO:0042592 homeostatic process 0.000532801864231105 1981 128 30 0.234375 0.0151438667339727
GO:BP GO:0097435 supramolecular fiber organization 0.000537243984837772 734 63 11 0.174603174603175 0.0149863760217984
GO:BP GO:1901575 organic substance catabolic process 0.000537420620309039 2267 10 7 0.7 0.00308778120864579
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.000544819901416124 6603 10 10 1 0.00151446312282296
GO:BP GO:0046907 intracellular transport 0.000553839582465352 1767 12 7 0.583333333333333 0.00396151669496321
GO:BP GO:0045859 regulation of protein kinase activity 0.000553839582465352 809 16 6 0.375 0.00741656365883807
GO:BP GO:0010629 negative regulation of gene expression 0.000557661899445056 1460 10 6 0.6 0.00410958904109589
GO:BP GO:0097193 intrinsic apoptotic signaling pathway 0.000560676636811737 294 13 4 0.307692307692308 0.0136054421768707
GO:BP GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 0.000577448226490164 100 13 3 0.230769230769231 0.03
GO:BP GO:0010628 positive regulation of gene expression 0.000577448226490164 1160 12 6 0.5 0.00517241379310345
GO:BP GO:0097501 stress response to metal ion 0.000646145585309797 16 84 3 0.0357142857142857 0.1875
GO:BP GO:0044248 cellular catabolic process 0.000646145585309797 2347 10 7 0.7 0.00298253089049851
GO:BP GO:0061687 detoxification of inorganic compound 0.000646145585309797 16 84 3 0.0357142857142857 0.1875
GO:BP GO:0071705 nitrogen compound transport 0.000646145585309797 2322 13 8 0.615384615384615 0.00344530577088717
GO:BP GO:0051248 negative regulation of protein metabolic process 0.000646145585309797 1151 29 9 0.310344827586207 0.00781928757602085
GO:BP GO:0016071 mRNA metabolic process 0.000663348190932424 874 10 5 0.5 0.005720823798627
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.000666124929632192 2518 29 13 0.448275862068966 0.00516282764098491
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 0.000676111414938827 503 16 5 0.3125 0.0099403578528827
GO:BP GO:0010564 regulation of cell cycle process 0.000676765184610082 809 6 4 0.666666666666667 0.00494437577255871
GO:BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 0.000690758752740195 162 9 3 0.333333333333333 0.0185185185185185
GO:BP GO:0071276 cellular response to cadmium ion 0.000710224649444214 37 104 4 0.0384615384615385 0.108108108108108
GO:BP GO:0010498 proteasomal protein catabolic process 0.000728791414037308 491 9 4 0.444444444444444 0.00814663951120163
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.000761059692017786 1037 9 5 0.555555555555556 0.00482160077145612
GO:BP GO:0043462 regulation of ATPase activity 0.000905625073801504 80 19 3 0.157894736842105 0.0375
GO:BP GO:0022402 cell cycle process 0.000953082501408832 1439 11 6 0.545454545454545 0.00416956219596942
GO:BP GO:0045862 positive regulation of proteolysis 0.000953082501408832 378 12 4 0.333333333333333 0.0105820105820106
GO:BP GO:0010970 transport along microtubule 0.000978203744345851 164 10 3 0.3 0.0182926829268293
GO:BP GO:0043933 protein-containing complex subunit organization 0.00097980878296687 1963 12 7 0.583333333333333 0.00356597045338767
GO:BP GO:0009059 macromolecule biosynthetic process 0.000983310854900719 5114 10 9 0.9 0.00175987485334376
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.000985267708381808 1103 9 5 0.555555555555556 0.00453309156844968
GO:BP GO:0070647 protein modification by small protein conjugation or removal 0.0010116811236002 1184 13 6 0.461538461538462 0.00506756756756757
GO:BP GO:0043549 regulation of kinase activity 0.0010116811236002 921 16 6 0.375 0.00651465798045603
GO:BP GO:0021953 central nervous system neuron differentiation 0.0010116811236002 188 9 3 0.333333333333333 0.0159574468085106
GO:BP GO:0048584 positive regulation of response to stimulus 0.00103131446801847 2344 17 9 0.529411764705882 0.00383959044368601
GO:BP GO:0019222 regulation of metabolic process 0.00103131446801847 7148 10 10 1 0.00139899272523783
GO:BP GO:0007034 vacuolar transport 0.0010604332427309 154 11 3 0.272727272727273 0.0194805194805195
GO:BP GO:0071897 DNA biosynthetic process 0.00109121592296371 195 9 3 0.333333333333333 0.0153846153846154
GO:BP GO:0030335 positive regulation of cell migration 0.00109220457038589 567 120 13 0.108333333333333 0.0229276895943563
GO:BP GO:0050896 response to stimulus 0.00113379018494366 9407 14 14 1 0.00148825342829808
GO:BP GO:0031400 negative regulation of protein modification process 0.00115078839879595 578 16 5 0.3125 0.00865051903114187
GO:BP GO:0007179 transforming growth factor beta receptor signaling pathway 0.00123959915474671 206 9 3 0.333333333333333 0.0145631067961165
GO:BP GO:0009892 negative regulation of metabolic process 0.0012637817592618 3479 13 9 0.692307692307692 0.00258695027306697
GO:BP GO:0070482 response to oxygen levels 0.00126879544500925 408 104 10 0.0961538461538462 0.0245098039215686
GO:BP GO:0070925 organelle assembly 0.00127421636601502 895 3 3 1 0.00335195530726257
GO:BP GO:0007018 microtubule-based movement 0.00127704145008717 383 13 4 0.307692307692308 0.010443864229765
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.00127815037910865 3083 17 10 0.588235294117647 0.00324359390204346
GO:BP GO:0010043 response to zinc ion 0.00128113151479737 55 84 4 0.0476190476190476 0.0727272727272727
GO:BP GO:1903047 mitotic cell cycle process 0.00131240078502975 911 3 3 1 0.00329308452250274
GO:BP GO:2000112 regulation of cellular macromolecule biosynthetic process 0.00132472976650337 4071 6 6 1 0.00147383935151069
GO:BP GO:0043065 positive regulation of apoptotic process 0.00133622135244694 604 16 5 0.3125 0.00827814569536424
GO:BP GO:0072655 establishment of protein localization to mitochondrion 0.00133622135244694 143 13 3 0.230769230769231 0.020979020979021
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 0.00135077810964934 4091 6 6 1 0.00146663407479834
GO:BP GO:0022600 digestive system process 0.00139514680813726 102 88 5 0.0568181818181818 0.0490196078431373
GO:BP GO:0072593 reactive oxygen species metabolic process 0.00139514680813726 290 71 7 0.0985915492957746 0.0241379310344828
GO:BP GO:0030277 maintenance of gastrointestinal epithelium 0.00139514680813726 21 88 3 0.0340909090909091 0.142857142857143
GO:BP GO:0070585 protein localization to mitochondrion 0.00141296201149091 147 13 3 0.230769230769231 0.0204081632653061
GO:BP GO:0051716 cellular response to stimulus 0.00141484170723947 7781 14 13 0.928571428571429 0.0016707364092019
GO:BP GO:0009056 catabolic process 0.00141956931300953 2744 10 7 0.7 0.00255102040816327
GO:BP GO:0099111 microtubule-based transport 0.00143947417326885 198 10 3 0.3 0.0151515151515152
GO:BP GO:0048523 negative regulation of cellular process 0.00143947417326885 5139 58 30 0.517241379310345 0.00583771161704612
GO:BP GO:0006605 protein targeting 0.00144276930430805 441 12 4 0.333333333333333 0.0090702947845805
GO:BP GO:0043068 positive regulation of programmed cell death 0.0014549824267355 621 16 5 0.3125 0.00805152979066022
GO:BP GO:0022607 cellular component assembly 0.00147522597113006 3010 12 8 0.666666666666667 0.0026578073089701
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.00148628283505886 5848 13 11 0.846153846153846 0.00188098495212038
GO:BP GO:0030705 cytoskeleton-dependent intracellular transport 0.00149889627528207 202 10 3 0.3 0.0148514851485149
GO:BP GO:0071294 cellular response to zinc ion 0.00153592436803976 23 84 3 0.0357142857142857 0.130434782608696
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.00154440659394488 1455 12 6 0.5 0.00412371134020619
GO:BP GO:0035902 response to immobilization stress 0.00155069938009384 28 69 3 0.0434782608695652 0.107142857142857
GO:BP GO:0040008 regulation of growth 0.00158066368341355 681 66 10 0.151515151515152 0.0146842878120411
GO:BP GO:0051338 regulation of transferase activity 0.00158675283858161 1035 16 6 0.375 0.00579710144927536
GO:BP GO:0031326 regulation of cellular biosynthetic process 0.00162542619121309 4273 6 6 1 0.0014041656915516
GO:BP GO:0051707 response to other organism 0.00168717237728409 1592 124 24 0.193548387096774 0.0150753768844221
GO:BP GO:0071702 organic substance transport 0.00170770145261829 2766 13 8 0.615384615384615 0.00289226319595083
GO:BP GO:0043207 response to external biotic stimulus 0.00170770145261829 1594 124 24 0.193548387096774 0.0150564617314931
GO:BP GO:0065008 regulation of biological quality 0.00171014129872323 4131 12 9 0.75 0.00217864923747277
GO:BP GO:0006511 ubiquitin-dependent protein catabolic process 0.00171014129872323 655 9 4 0.444444444444444 0.00610687022900763
GO:BP GO:0008104 protein localization 0.00171014129872323 2770 13 8 0.615384615384615 0.00288808664259928
GO:BP GO:0035556 intracellular signal transduction 0.00171395790595252 2772 13 8 0.615384615384615 0.00288600288600289
GO:BP GO:0019941 modification-dependent protein catabolic process 0.00176580944722983 662 9 4 0.444444444444444 0.00604229607250755
GO:BP GO:0001890 placenta development 0.00180605843970437 147 66 5 0.0757575757575758 0.0340136054421769
GO:BP GO:0000278 mitotic cell cycle 0.00181916015123477 1059 3 3 1 0.0028328611898017
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.00185048383094273 3274 17 10 0.588235294117647 0.0030543677458766
GO:BP GO:0043632 modification-dependent macromolecule catabolic process 0.00185048383094273 673 9 4 0.444444444444444 0.00594353640416048
GO:BP GO:0048519 negative regulation of biological process 0.00189430375944047 5757 63 34 0.53968253968254 0.00590585374326906
GO:BP GO:0080090 regulation of primary metabolic process 0.00191583840427633 6053 13 11 0.846153846153846 0.00181728068726251
GO:BP GO:0071560 cellular response to transforming growth factor beta stimulus 0.00193450598738345 256 9 3 0.333333333333333 0.01171875
GO:BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.00195132131140301 257 9 3 0.333333333333333 0.0116731517509728
GO:BP GO:0010942 positive regulation of cell death 0.00202964965144199 684 16 5 0.3125 0.00730994152046784
GO:BP GO:0071559 response to transforming growth factor beta 0.00204217913033132 262 9 3 0.333333333333333 0.0114503816793893
GO:BP GO:0009607 response to biotic stimulus 0.00211827817778635 1626 124 24 0.193548387096774 0.014760147601476
GO:BP GO:0002682 regulation of immune system process 0.00214774900165843 1617 8 5 0.625 0.00309214594928881
GO:BP GO:0006820 anion transport 0.00214774900165843 2889 13 8 0.615384615384615 0.00276912426445137
GO:BP GO:0051091 positive regulation of DNA-binding transcription factor activity 0.0021944295808504 270 9 3 0.333333333333333 0.0111111111111111
GO:BP GO:0051130 positive regulation of cellular component organization 0.0021944295808504 1153 3 3 1 0.002601908065915
GO:BP GO:0071280 cellular response to copper ion 0.00220733294913593 27 84 3 0.0357142857142857 0.111111111111111
GO:BP GO:0001666 response to hypoxia 0.00223441773416147 367 104 9 0.0865384615384615 0.0245231607629428
GO:BP GO:0044085 cellular component biogenesis 0.00226408592777282 3257 12 8 0.666666666666667 0.00245624808105619
GO:BP GO:0007163 establishment or maintenance of cell polarity 0.00228180308113804 220 11 3 0.272727272727273 0.0136363636363636
GO:BP GO:0071363 cellular response to growth factor stimulus 0.0023482518068687 731 9 4 0.444444444444444 0.00547195622435021
GO:BP GO:0051129 negative regulation of cellular component organization 0.00234962081088761 759 4 3 0.75 0.00395256916996047
GO:BP GO:0043297 apical junction assembly 0.00242672584198871 88 120 5 0.0416666666666667 0.0568181818181818
GO:BP GO:0052548 regulation of endopeptidase activity 0.00245875155758782 437 71 8 0.112676056338028 0.0183066361556064
GO:BP GO:0031323 regulation of cellular metabolic process 0.0025019148472234 6269 13 11 0.846153846153846 0.0017546658159196
GO:BP GO:0051603 proteolysis involved in cellular protein catabolic process 0.00251182346131734 750 9 4 0.444444444444444 0.00533333333333333
GO:BP GO:0051128 regulation of cellular component organization 0.00252753271719077 2412 4 4 1 0.00165837479270315
GO:BP GO:0032940 secretion by cell 0.00255919799560186 1364 14 6 0.428571428571429 0.00439882697947214
GO:BP GO:0070848 response to growth factor 0.00260227257446114 759 9 4 0.444444444444444 0.00527009222661397
GO:BP GO:0008285 negative regulation of cell population proliferation 0.00264238556150656 790 111 14 0.126126126126126 0.0177215189873418
GO:BP GO:0060249 anatomical structure homeostasis 0.0027693385896107 482 6 3 0.5 0.00622406639004149
GO:BP GO:0036293 response to decreased oxygen levels 0.0027693385896107 382 104 9 0.0865384615384615 0.0235602094240838
GO:BP GO:0051179 localization 0.00278230981104161 6901 14 12 0.857142857142857 0.0017388784234169
GO:BP GO:0010669 epithelial structure maintenance 0.00287991086949378 29 88 3 0.0340909090909091 0.103448275862069
GO:BP GO:0051674 localization of cell 0.00299260600976081 1828 121 25 0.206611570247934 0.0136761487964989
GO:BP GO:0048870 cell motility 0.00299260600976081 1828 121 25 0.206611570247934 0.0136761487964989
GO:BP GO:0098869 cellular oxidant detoxification 0.00301573423255189 100 112 5 0.0446428571428571 0.05
GO:BP GO:0140352 export from cell 0.00304442010388634 1418 14 6 0.428571428571429 0.00423131170662906
GO:BP GO:0007166 cell surface receptor signaling pathway 0.00304777695751186 3210 10 7 0.7 0.00218068535825545
GO:BP GO:0051094 positive regulation of developmental process 0.00305040751551784 1341 6 4 0.666666666666667 0.00298284862043251
GO:BP GO:0090287 regulation of cellular response to growth factor stimulus 0.00310088975104481 315 9 3 0.333333333333333 0.00952380952380952
GO:BP GO:0031667 response to nutrient levels 0.00317136341568598 482 122 11 0.0901639344262295 0.0228215767634855
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.00320306195073773 3241 10 7 0.7 0.00215982721382289
GO:BP GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 0.0032101559264693 23 117 3 0.0256410256410256 0.130434782608696
GO:BP GO:0001932 regulation of protein phosphorylation 0.00336319560312039 1240 16 6 0.375 0.00483870967741936
GO:BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.00336319560312039 217 114 7 0.0614035087719298 0.032258064516129
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 0.00337332720169246 5017 6 6 1 0.00119593382499502
GO:BP GO:1904589 regulation of protein import 0.00342421206891003 65 42 3 0.0714285714285714 0.0461538461538462
GO:BP GO:0034645 cellular macromolecule biosynthetic process 0.00349172181974562 5051 6 6 1 0.00118788358740843
GO:BP GO:0048731 system development 0.00349172181974562 5052 6 6 1 0.00118764845605701
GO:BP GO:1901576 organic substance biosynthetic process 0.00352135610138838 6248 10 9 0.9 0.0014404609475032
GO:BP GO:0009966 regulation of signal transduction 0.00355260223817658 3165 13 8 0.615384615384615 0.00252764612954186
GO:BP GO:0009967 positive regulation of signal transduction 0.00364018129448261 1598 9 5 0.555555555555556 0.00312891113892365
GO:BP GO:0009653 anatomical structure morphogenesis 0.00371967536449405 2797 52 18 0.346153846153846 0.00643546657132642
GO:BP GO:0048565 digestive tract development 0.00372634190060969 129 52 4 0.0769230769230769 0.0310077519379845
GO:BP GO:0051239 regulation of multicellular organismal process 0.00372634190060969 2861 6 5 0.833333333333333 0.00174764068507515
GO:BP GO:1901700 response to oxygen-containing compound 0.00373389925315545 1739 122 24 0.19672131147541 0.0138010350776308
GO:BP GO:0016477 cell migration 0.00379416199542844 1649 121 23 0.190082644628099 0.0139478471801092
GO:BP GO:0009605 response to external stimulus 0.00382196823060598 2944 124 35 0.282258064516129 0.0118885869565217
GO:BP GO:0009058 biosynthetic process 0.00386056816777928 6340 10 9 0.9 0.00141955835962145
GO:BP GO:0046903 secretion 0.00386056816777928 1501 14 6 0.428571428571429 0.00399733510992672
GO:BP GO:0032502 developmental process 0.00386168125630256 6628 13 11 0.846153846153846 0.00165962582981291
GO:BP GO:0033036 macromolecule localization 0.00386168125630256 3218 13 8 0.615384615384615 0.00248601615910503
GO:BP GO:0010468 regulation of gene expression 0.003943819616578 5196 6 6 1 0.00115473441108545
GO:BP GO:0046034 ATP metabolic process 0.00399620785408757 314 10 3 0.3 0.00955414012738853
GO:BP GO:0090304 nucleic acid metabolic process 0.00405459790834745 5226 6 6 1 0.00114810562571757
GO:BP GO:0006508 proteolysis 0.00407105258812952 1836 12 6 0.5 0.00326797385620915
GO:BP GO:0007254 JNK cascade 0.00434355992492735 195 16 3 0.1875 0.0153846153846154
GO:BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 0.00448083944752407 369 9 3 0.333333333333333 0.00813008130081301
GO:BP GO:0055123 digestive system development 0.00457045717472276 138 52 4 0.0769230769230769 0.0289855072463768
GO:BP GO:0043086 negative regulation of catalytic activity 0.00457045717472276 851 63 10 0.158730158730159 0.0117508813160987
GO:BP GO:0006882 cellular zinc ion homeostasis 0.00458710299029946 37 84 3 0.0357142857142857 0.0810810810810811
GO:BP GO:0031960 response to corticosteroid 0.00465430460235128 165 44 4 0.0909090909090909 0.0242424242424242
GO:BP GO:1990748 cellular detoxification 0.00466955911064845 113 112 5 0.0446428571428571 0.0442477876106195
GO:BP GO:0009991 response to extracellular stimulus 0.00469475117175553 512 122 11 0.0901639344262295 0.021484375
GO:BP GO:1903747 regulation of establishment of protein localization to mitochondrion 0.00493192123361985 72 102 4 0.0392156862745098 0.0555555555555556
GO:BP GO:0060706 cell differentiation involved in embryonic placenta development 0.00500016063336955 27 120 3 0.025 0.111111111111111
GO:BP GO:0000302 response to reactive oxygen species 0.00509633857403867 237 114 7 0.0614035087719298 0.029535864978903
GO:BP GO:0055069 zinc ion homeostasis 0.00525432071117819 39 84 3 0.0357142857142857 0.0769230769230769
GO:BP GO:0010647 positive regulation of cell communication 0.00541568035866892 1777 9 5 0.555555555555556 0.0028137310073157
GO:BP GO:2000116 regulation of cysteine-type endopeptidase activity 0.00541568035866892 240 114 7 0.0614035087719298 0.0291666666666667
GO:BP GO:0046685 response to arsenic-containing substance 0.00541568035866892 32 104 3 0.0288461538461538 0.09375
GO:BP GO:0006955 immune response 0.0054471274683277 2311 14 7 0.5 0.00302899177845089
GO:BP GO:0023056 positive regulation of signaling 0.0054471274683277 1782 9 5 0.555555555555556 0.00280583613916947
GO:BP GO:0009611 response to wounding 0.00571818591342087 674 111 12 0.108108108108108 0.0178041543026706
GO:BP GO:0007275 multicellular organism development 0.00577312823963728 5613 6 6 1 0.00106894708711919
GO:BP GO:0001558 regulation of cell growth 0.00581287142062073 426 66 7 0.106060606060606 0.0164319248826291
GO:BP GO:0097237 cellular response to toxic substance 0.00581791451619624 120 112 5 0.0446428571428571 0.0416666666666667
GO:BP GO:0042325 regulation of phosphorylation 0.00619730130858815 1431 16 6 0.375 0.00419287211740042
GO:BP GO:0046688 response to copper ion 0.0062226932589864 42 84 3 0.0357142857142857 0.0714285714285714
GO:BP GO:0010608 posttranscriptional regulation of gene expression 0.00629368390722799 896 10 4 0.4 0.00446428571428571
GO:BP GO:0042542 response to hydrogen peroxide 0.00630189914202565 150 24 3 0.125 0.02
GO:BP GO:0031100 animal organ regeneration 0.00635295186461647 77 104 4 0.0384615384615385 0.051948051948052
GO:BP GO:0010035 response to inorganic substance 0.00635295186461647 575 114 11 0.0964912280701754 0.0191304347826087
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.00640650253557033 5746 6 6 1 0.00104420466411417
GO:BP GO:0045860 positive regulation of protein kinase activity 0.00644469348545081 534 16 4 0.25 0.00749063670411985
GO:BP GO:1902903 regulation of supramolecular fiber organization 0.00651834495336902 387 10 3 0.3 0.00775193798449612
GO:BP GO:0007417 central nervous system development 0.00656049678902068 1032 9 4 0.444444444444444 0.00387596899224806
GO:BP GO:0010646 regulation of cell communication 0.00663567462968868 3543 13 8 0.615384615384615 0.00225797346881174
GO:BP GO:1901214 regulation of neuron death 0.00684171593409662 323 12 3 0.25 0.00928792569659443
GO:BP GO:0000280 nuclear division 0.00701897812696856 448 9 3 0.333333333333333 0.00669642857142857
GO:BP GO:0006928 movement of cell or subcellular component 0.00703475405578967 2311 121 28 0.231404958677686 0.0121159671138035
GO:BP GO:0023051 regulation of signaling 0.00703475405578967 3578 13 8 0.615384615384615 0.00223588596981554
GO:BP GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 0.00704612217864733 92 90 4 0.0444444444444444 0.0434782608695652
GO:BP GO:0001892 embryonic placenta development 0.00706276509520381 83 45 3 0.0666666666666667 0.036144578313253
GO:BP GO:0019538 protein metabolic process 0.00718305229442189 5808 13 10 0.769230769230769 0.00172176308539945
GO:BP GO:0051090 regulation of DNA-binding transcription factor activity 0.00729979271543511 456 9 3 0.333333333333333 0.00657894736842105
GO:BP GO:0046483 heterocycle metabolic process 0.00733036903142315 5904 6 6 1 0.00101626016260163
GO:BP GO:0002376 immune system process 0.00737263037105651 3278 14 8 0.571428571428571 0.0024405125076266
GO:BP GO:0035295 tube development 0.00761376331359863 1146 43 9 0.209302325581395 0.00785340314136126
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.00763582554759048 5956 6 6 1 0.0010073875083949
GO:BP GO:0006469 negative regulation of protein kinase activity 0.00777060513272148 251 16 3 0.1875 0.0119521912350598
GO:BP GO:0006811 ion transport 0.00800861494857472 3661 13 8 0.615384615384615 0.0021851953018301
GO:BP GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 0.00800861494857472 83 104 4 0.0384615384615385 0.0481927710843374
GO:BP GO:0061024 membrane organization 0.00802596456061527 973 10 4 0.4 0.00411099691675231
GO:BP GO:0048856 anatomical structure development 0.00862893396198786 6106 6 6 1 0.000982640026203734
GO:BP GO:0008637 apoptotic mitochondrial changes 0.00886814985316288 126 71 4 0.0563380281690141 0.0317460317460317
GO:BP GO:0048545 response to steroid hormone 0.00886814985316288 349 44 5 0.113636363636364 0.0143266475644699
GO:BP GO:0048285 organelle fission 0.00890566530087003 497 9 3 0.333333333333333 0.00603621730382294
GO:BP GO:0045861 negative regulation of proteolysis 0.00890566530087003 359 63 6 0.0952380952380952 0.0167130919220056
GO:BP GO:0044249 cellular biosynthetic process 0.00894199465265316 6154 6 6 1 0.00097497562560936
GO:BP GO:0070997 neuron death 0.0090704931879071 365 12 3 0.25 0.00821917808219178
GO:BP GO:0071621 granulocyte chemotaxis 0.00911079291010828 126 121 5 0.0413223140495868 0.0396825396825397
GO:BP GO:0010467 gene expression 0.00911079291010828 6179 6 6 1 0.000971030911150672
GO:BP GO:0010952 positive regulation of peptidase activity 0.00911508799056965 205 110 6 0.0545454545454545 0.0292682926829268
GO:BP GO:1901360 organic cyclic compound metabolic process 0.00925524896911394 6201 6 6 1 0.000967585873246251
GO:BP GO:0051403 stress-activated MAPK cascade 0.00931435741330425 272 16 3 0.1875 0.0110294117647059
GO:BP GO:0071156 regulation of cell cycle arrest 0.00939208577677376 115 37 3 0.0810810810810811 0.0260869565217391
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 0.00939208577677376 4199 12 8 0.666666666666667 0.00190521552750655
GO:BP GO:0033674 positive regulation of kinase activity 0.00939208577677376 608 16 4 0.25 0.00657894736842105
GO:BP GO:0006626 protein targeting to mitochondrion 0.00939208577677376 101 42 3 0.0714285714285714 0.0297029702970297
GO:BP GO:0033673 negative regulation of kinase activity 0.00945370888526644 275 16 3 0.1875 0.0109090909090909
GO:BP GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 0.00945370888526644 41 104 3 0.0288461538461538 0.0731707317073171
GO:BP GO:0040011 locomotion 0.00977301260473534 2028 121 25 0.206611570247934 0.01232741617357
GO:BP GO:0018130 heterocycle biosynthetic process 0.0102505187311052 4269 12 8 0.666666666666667 0.001873975169829
GO:BP GO:0009968 negative regulation of signal transduction 0.0102904392617018 1364 13 5 0.384615384615385 0.00366568914956012
GO:BP GO:0010951 negative regulation of endopeptidase activity 0.010294274258834 253 63 5 0.0793650793650794 0.0197628458498024
GO:BP GO:0022610 biological adhesion 0.0103027640645223 1499 12 5 0.416666666666667 0.00333555703802535
GO:BP GO:0019438 aromatic compound biosynthetic process 0.01032755512009 4278 12 8 0.666666666666667 0.0018700327255727
GO:BP GO:0031098 stress-activated protein kinase signaling cascade 0.0105382552842972 288 16 3 0.1875 0.0104166666666667
GO:BP GO:1903827 regulation of cellular protein localization 0.0106017107019306 572 42 6 0.142857142857143 0.0104895104895105
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 0.0107579685473202 1887 10 5 0.5 0.00264970853206147
GO:BP GO:0008217 regulation of blood pressure 0.0107593481027677 193 122 6 0.0491803278688525 0.0310880829015544
GO:BP GO:0070830 bicellular tight junction assembly 0.0107593481027677 80 120 4 0.0333333333333333 0.05
GO:BP GO:0051174 regulation of phosphorus metabolic process 0.0108158637114621 1645 16 6 0.375 0.00364741641337386
GO:BP GO:0019220 regulation of phosphate metabolic process 0.0108158637114621 1645 16 6 0.375 0.00364741641337386
GO:BP GO:0042060 wound healing 0.0108338054349996 549 111 10 0.0900900900900901 0.0182149362477231
GO:BP GO:0045597 positive regulation of cell differentiation 0.0109951732110954 879 6 3 0.5 0.00341296928327645
GO:BP GO:0043542 endothelial cell migration 0.0110851502629101 290 111 7 0.0630630630630631 0.0241379310344828
GO:BP GO:0043170 macromolecule metabolic process 0.0114177697040076 9796 10 10 1 0.00102082482645978
GO:BP GO:0006468 protein phosphorylation 0.011463452335042 1668 16 6 0.375 0.00359712230215827
GO:BP GO:0120192 tight junction assembly 0.011463452335042 82 120 4 0.0333333333333333 0.0487804878048781
GO:BP GO:0032989 cellular component morphogenesis 0.0116190208196811 791 66 9 0.136363636363636 0.011378002528445
GO:BP GO:0002831 regulation of response to biotic stimulus 0.0118296903854305 415 12 3 0.25 0.0072289156626506
GO:BP GO:0034641 cellular nitrogen compound metabolic process 0.0118416547899669 6563 6 6 1 0.000914216059728783
GO:BP GO:0042311 vasodilation 0.011951479772655 39 122 3 0.0245901639344262 0.0769230769230769
GO:BP GO:0043524 negative regulation of neuron apoptotic process 0.0120477066704695 150 111 5 0.045045045045045 0.0333333333333333
GO:BP GO:0062013 positive regulation of small molecule metabolic process 0.0121063051441617 145 115 5 0.0434782608695652 0.0344827586206897
GO:BP GO:0010466 negative regulation of peptidase activity 0.0121829520647611 267 63 5 0.0793650793650794 0.0187265917602996
GO:BP GO:0051348 negative regulation of transferase activity 0.0122027921102693 310 16 3 0.1875 0.00967741935483871
GO:BP GO:0001894 tissue homeostasis 0.0122027921102693 270 122 7 0.0573770491803279 0.0259259259259259
GO:BP GO:0007165 signal transduction 0.0123606449328873 6309 13 10 0.769230769230769 0.00158503724837534
GO:BP GO:1901362 organic cyclic compound biosynthetic process 0.0124056039296352 4439 12 8 0.666666666666667 0.00180220770443794
GO:BP GO:0043405 regulation of MAP kinase activity 0.0125536758368849 316 16 3 0.1875 0.00949367088607595
GO:BP GO:0071902 positive regulation of protein serine/threonine kinase activity 0.0125536758368849 316 16 3 0.1875 0.00949367088607595
GO:BP GO:0000902 cell morphogenesis 0.0127739630568889 1037 11 4 0.363636363636364 0.0038572806171649
GO:BP GO:1903035 negative regulation of response to wounding 0.0128441751009426 93 111 4 0.036036036036036 0.043010752688172
GO:BP GO:0010648 negative regulation of cell communication 0.0128491844926456 1468 13 5 0.384615384615385 0.00340599455040872
GO:BP GO:0044092 negative regulation of molecular function 0.0128811381339566 1219 29 7 0.241379310344828 0.00574241181296144
GO:BP GO:0023057 negative regulation of signaling 0.0129243214099721 1471 13 5 0.384615384615385 0.00339904826648538
GO:BP GO:0051347 positive regulation of transferase activity 0.0130319856655055 689 16 4 0.25 0.0058055152394775
GO:BP GO:0050794 regulation of cellular process 0.0130589629712594 11473 13 13 1 0.00113309509282664
GO:BP GO:0120193 tight junction organization 0.0131771240496894 87 120 4 0.0333333333333333 0.0459770114942529
GO:BP GO:0036211 protein modification process 0.0132304754487023 4041 6 5 0.833333333333333 0.00123731749566939
GO:BP GO:0006464 cellular protein modification process 0.0132304754487023 4041 6 5 0.833333333333333 0.00123731749566939
GO:BP GO:0070268 cornification 0.0132568399878123 112 45 3 0.0666666666666667 0.0267857142857143
GO:BP GO:0006952 defense response 0.013307287275159 1818 124 23 0.185483870967742 0.0126512651265127
GO:BP GO:0061919 process utilizing autophagic mechanism 0.0133840409363809 543 10 3 0.3 0.00552486187845304
GO:BP GO:0006914 autophagy 0.0133840409363809 543 10 3 0.3 0.00552486187845304
GO:BP GO:0006259 DNA metabolic process 0.0136172982440817 965 12 4 0.333333333333333 0.00414507772020725
GO:BP GO:0032501 multicellular organismal process 0.0136957350731595 7946 46 30 0.652173913043478 0.00377548452051347
GO:BP GO:0060429 epithelium development 0.0139798566015706 1325 50 10 0.2 0.00754716981132075
GO:BP GO:0044267 cellular protein metabolic process 0.0141015535570199 5229 13 9 0.692307692307692 0.00172117039586919
GO:BP GO:0032880 regulation of protein localization 0.0151942261778007 922 13 4 0.307692307692308 0.00433839479392625
GO:BP GO:0007043 cell-cell junction assembly 0.0152483612252021 151 120 5 0.0416666666666667 0.033112582781457
GO:BP GO:0009062 fatty acid catabolic process 0.01545748479706 107 51 3 0.0588235294117647 0.0280373831775701
GO:BP GO:0032101 regulation of response to external stimulus 0.0155039855249336 1051 6 3 0.5 0.00285442435775452
GO:BP GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 0.0155642259623418 77 71 3 0.0422535211267606 0.038961038961039
GO:BP GO:0043412 macromolecule modification 0.0156190823536214 4257 6 5 0.833333333333333 0.00117453605825699
GO:BP GO:0097530 granulocyte migration 0.0156190823536214 151 121 5 0.0413223140495868 0.033112582781457
GO:BP GO:0048812 neuron projection morphogenesis 0.0157448288720047 664 9 3 0.333333333333333 0.00451807228915663
GO:BP GO:0071901 negative regulation of protein serine/threonine kinase activity 0.0158498015940897 150 37 3 0.0810810810810811 0.02
GO:BP GO:0032103 positive regulation of response to external stimulus 0.0160024166686589 513 108 9 0.0833333333333333 0.0175438596491228
GO:BP GO:0042493 response to drug 0.0160024166686589 396 114 8 0.0701754385964912 0.0202020202020202
GO:BP GO:0009890 negative regulation of biosynthetic process 0.0160894272818688 1740 12 5 0.416666666666667 0.0028735632183908
GO:BP GO:0002011 morphogenesis of an epithelial sheet 0.0162907823370167 58 97 3 0.0309278350515464 0.0517241379310345
GO:BP GO:0120039 plasma membrane bounded cell projection morphogenesis 0.0162907823370167 678 9 3 0.333333333333333 0.00442477876106195
GO:BP GO:0048858 cell projection morphogenesis 0.0165036606836817 682 9 3 0.333333333333333 0.00439882697947214
GO:BP GO:1903034 regulation of response to wounding 0.0168715339368563 169 111 5 0.045045045045045 0.029585798816568
GO:BP GO:0010594 regulation of endothelial cell migration 0.0170698976617036 244 111 6 0.0540540540540541 0.0245901639344262
GO:BP GO:0001933 negative regulation of protein phosphorylation 0.0171126896314421 373 16 3 0.1875 0.00804289544235925
GO:BP GO:0002684 positive regulation of immune system process 0.0172700387938772 1065 12 4 0.333333333333333 0.00375586854460094
GO:BP GO:0032990 cell part morphogenesis 0.0173263002345567 699 9 3 0.333333333333333 0.00429184549356223
GO:BP GO:1990869 cellular response to chemokine 0.0174186934073544 97 121 4 0.0330578512396694 0.0412371134020619
GO:BP GO:1990868 response to chemokine 0.0174186934073544 97 121 4 0.0330578512396694 0.0412371134020619
GO:BP GO:0048608 reproductive structure development 0.0174251551120062 429 45 5 0.111111111111111 0.0116550116550117
GO:BP GO:0048871 multicellular organismal homeostasis 0.0176553897917664 530 127 10 0.078740157480315 0.0188679245283019
GO:BP GO:0061458 reproductive system development 0.0177869483557695 432 45 5 0.111111111111111 0.0115740740740741
GO:BP GO:0045892 negative regulation of transcription, DNA-templated 0.0181498554154191 1337 10 4 0.4 0.00299177262528048
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 0.0182239598490036 1339 10 4 0.4 0.00298730395817774
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 0.0182982360801782 1341 10 4 0.4 0.00298284862043251
GO:BP GO:1905897 regulation of response to endoplasmic reticulum stress 0.0183237199014891 84 71 3 0.0422535211267606 0.0357142857142857
GO:BP GO:0046916 cellular transition metal ion homeostasis 0.0186472109760301 116 104 4 0.0384615384615385 0.0344827586206897
GO:BP GO:2000026 regulation of multicellular organismal development 0.0186615322299701 1447 5 3 0.6 0.00207325501036628
GO:BP GO:1901564 organonitrogen compound metabolic process 0.0186949326520722 6792 13 10 0.769230769230769 0.00147232037691402
GO:BP GO:0042127 regulation of cell population proliferation 0.0187966271216846 1774 117 21 0.179487179487179 0.0118376550169109
GO:BP GO:0044260 cellular macromolecule metabolic process 0.0188566709937751 8390 7 7 1 0.000834326579261025
GO:BP GO:0023052 signaling 0.0190096956938261 6810 13 10 0.769230769230769 0.00146842878120411
GO:BP GO:0090559 regulation of membrane permeability 0.0190096956938261 95 128 4 0.03125 0.0421052631578947
GO:BP GO:0009719 response to endogenous stimulus 0.0191281777680611 1683 13 5 0.384615384615385 0.0029708853238265
GO:BP GO:0030865 cortical cytoskeleton organization 0.0191281777680611 63 97 3 0.0309278350515464 0.0476190476190476
GO:BP GO:0007154 cell communication 0.0192657968965053 6829 13 10 0.769230769230769 0.00146434324205594
GO:BP GO:0051384 response to glucocorticoid 0.0201752532604807 146 43 3 0.0697674418604651 0.0205479452054795
GO:BP GO:0050793 regulation of developmental process 0.0202240224610223 2605 6 4 0.666666666666667 0.00153550863723608
GO:BP GO:0030593 neutrophil chemotaxis 0.0202688885281432 103 121 4 0.0330578512396694 0.0388349514563107
GO:BP GO:0050789 regulation of biological process 0.0208245786134467 12091 13 13 1 0.00107517988586552
GO:BP GO:1903829 positive regulation of cellular protein localization 0.0208317748757843 303 42 4 0.0952380952380952 0.0132013201320132
GO:BP GO:0006606 protein import into nucleus 0.0208620374992282 152 42 3 0.0714285714285714 0.0197368421052632
GO:BP GO:1904018 positive regulation of vasculature development 0.0208620374992282 187 108 5 0.0462962962962963 0.0267379679144385
GO:BP GO:0045766 positive regulation of angiogenesis 0.0208620374992282 187 108 5 0.0462962962962963 0.0267379679144385
GO:BP GO:0048585 negative regulation of response to stimulus 0.0210349543373101 1733 13 5 0.384615384615385 0.00288517022504328
GO:BP GO:0035924 cellular response to vascular endothelial growth factor stimulus 0.0210349543373101 81 79 3 0.0379746835443038 0.037037037037037
GO:BP GO:0051252 regulation of RNA metabolic process 0.0210349543373101 3822 12 7 0.583333333333333 0.00183150183150183
GO:BP GO:0001934 positive regulation of protein phosphorylation 0.0210349543373101 840 16 4 0.25 0.00476190476190476
GO:BP GO:0042326 negative regulation of phosphorylation 0.0217127954443931 420 16 3 0.1875 0.00714285714285714
GO:BP GO:0016042 lipid catabolic process 0.0222643795666301 349 111 7 0.0630630630630631 0.0200573065902579
GO:BP GO:0051253 negative regulation of RNA metabolic process 0.0223415706762291 1445 10 4 0.4 0.0027681660899654
GO:BP GO:0051346 negative regulation of hydrolase activity 0.0223894488426937 470 63 6 0.0952380952380952 0.0127659574468085
GO:BP GO:0008283 cell population proliferation 0.0225772016258022 2054 117 23 0.196581196581197 0.0111976630963973
GO:BP GO:0035821 modulation of process of other organism 0.0229216895084344 128 52 3 0.0576923076923077 0.0234375
GO:BP GO:0030154 cell differentiation 0.0229216895084344 4350 11 7 0.636363636363636 0.00160919540229885
GO:BP GO:0042692 muscle cell differentiation 0.0230525463179768 390 54 5 0.0925925925925926 0.0128205128205128
GO:BP GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 0.023132565155756 55 122 3 0.0245901639344262 0.0545454545454545
GO:BP GO:0072329 monocarboxylic acid catabolic process 0.023132565155756 132 51 3 0.0588235294117647 0.0227272727272727
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.0236439609729918 549 13 3 0.230769230769231 0.00546448087431694
GO:BP GO:0048869 cellular developmental process 0.0245853073746571 4428 11 7 0.636363636363636 0.00158084914182475
GO:BP GO:0031099 regeneration 0.024939624157021 206 104 5 0.0480769230769231 0.0242718446601942
GO:BP GO:0007155 cell adhesion 0.0252765647509614 1492 50 10 0.2 0.00670241286863271
GO:BP GO:0030336 negative regulation of cell migration 0.0256349689942314 353 114 7 0.0614035087719298 0.0198300283286119
GO:BP GO:0044242 cellular lipid catabolic process 0.0265459467906463 232 60 4 0.0666666666666667 0.0172413793103448
GO:BP GO:0016043 cellular component organization 0.0265459467906463 6566 12 9 0.75 0.00137069753274444
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 0.0266190864635443 1548 10 4 0.4 0.00258397932816537
GO:BP GO:0071248 cellular response to metal ion 0.0266627761519585 192 114 5 0.043859649122807 0.0260416666666667
GO:BP GO:0051170 import into nucleus 0.026673379239661 172 42 3 0.0714285714285714 0.0174418604651163
GO:BP GO:0006898 receptor-mediated endocytosis 0.026673379239661 333 122 7 0.0573770491803279 0.021021021021021
GO:BP GO:0051851 modulation by host of symbiont process 0.0268133478661726 65 111 3 0.027027027027027 0.0461538461538462
GO:BP GO:0016310 phosphorylation 0.0271055178593027 2138 16 6 0.375 0.00280636108512629
GO:BP GO:0042327 positive regulation of phosphorylation 0.0272231299409083 927 16 4 0.25 0.00431499460625674
GO:BP GO:0051223 regulation of protein transport 0.0272231299409083 586 13 3 0.230769230769231 0.00511945392491468
GO:BP GO:0048662 negative regulation of smooth muscle cell proliferation 0.0272530450245628 70 104 3 0.0288461538461538 0.0428571428571429
GO:BP GO:0016239 positive regulation of macroautophagy 0.0275702018036261 60 122 3 0.0245901639344262 0.05
GO:BP GO:0010631 epithelial cell migration 0.0276562509716241 370 111 7 0.0630630630630631 0.0189189189189189
GO:BP GO:0009725 response to hormone 0.0282751289920418 921 69 9 0.130434782608696 0.00977198697068404
GO:BP GO:0006996 organelle organization 0.0285418401799384 4104 12 7 0.583333333333333 0.0017056530214425
GO:BP GO:0090132 epithelium migration 0.0285418401799384 373 111 7 0.0630630630630631 0.0187667560321716
GO:BP GO:0042594 response to starvation 0.0286641622963623 202 71 4 0.0563380281690141 0.0198019801980198
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 0.0288157491405004 901 9 3 0.333333333333333 0.00332963374028857
GO:BP GO:0055076 transition metal ion homeostasis 0.0288502482459018 138 104 4 0.0384615384615385 0.0289855072463768
GO:BP GO:0070201 regulation of establishment of protein localization 0.0293821595345326 611 13 3 0.230769230769231 0.00490998363338789
GO:BP GO:0048771 tissue remodeling 0.0294317079535318 186 122 5 0.040983606557377 0.0268817204301075
GO:BP GO:2000146 negative regulation of cell motility 0.0299035200172366 369 114 7 0.0614035087719298 0.018970189701897
GO:BP GO:0090087 regulation of peptide transport 0.0299035200172366 618 13 3 0.230769230769231 0.00485436893203883
GO:BP GO:2000113 negative regulation of cellular macromolecule biosynthetic process 0.0299035200172366 1628 10 4 0.4 0.00245700245700246
GO:BP GO:0090130 tissue migration 0.0299035200172366 379 111 7 0.0630630630630631 0.0184696569920844
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 0.0302394575133869 1639 10 4 0.4 0.0024405125076266
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 0.0302394575133869 1851 9 4 0.444444444444444 0.00216099405726634
GO:BP GO:0010038 response to metal ion 0.0304483821139974 371 114 7 0.0614035087719298 0.0188679245283019
GO:BP GO:0071840 cellular component organization or biogenesis 0.0304875973229363 6760 12 9 0.75 0.00133136094674556
GO:BP GO:0071704 organic substance metabolic process 0.0305059546139593 11326 10 10 1 0.00088292424509977
GO:BP GO:0048589 developmental growth 0.0306249415587027 649 66 7 0.106060606060606 0.0107858243451464
GO:BP GO:0007219 Notch signaling pathway 0.0307270038999345 193 120 5 0.0416666666666667 0.0259067357512953
GO:BP GO:1990266 neutrophil migration 0.0317339640257213 124 121 4 0.0330578512396694 0.032258064516129
GO:BP GO:0061041 regulation of wound healing 0.0322159876329217 136 111 4 0.036036036036036 0.0294117647058824
GO:BP GO:0002237 response to molecule of bacterial origin 0.0322401010740077 361 119 7 0.0588235294117647 0.0193905817174515
GO:BP GO:0051271 negative regulation of cellular component movement 0.0322401010740077 377 114 7 0.0614035087719298 0.0185676392572944
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 0.0322496964893726 1001 16 4 0.25 0.003996003996004
GO:BP GO:0031347 regulation of defense response 0.0322496964893726 704 12 3 0.25 0.00426136363636364
GO:BP GO:0045937 positive regulation of phosphate metabolic process 0.0322496964893726 1001 16 4 0.25 0.003996003996004
GO:BP GO:0050921 positive regulation of chemotaxis 0.0328495034377382 141 108 4 0.037037037037037 0.0283687943262411
GO:BP GO:0002548 monocyte chemotaxis 0.0331543196687381 67 121 3 0.0247933884297521 0.0447761194029851
GO:BP GO:0043627 response to estrogen 0.0331944164094979 78 104 3 0.0288461538461538 0.0384615384615385
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 0.0334607526974133 1707 10 4 0.4 0.00234329232571763
GO:BP GO:0071346 cellular response to interferon-gamma 0.0338634829264088 175 47 3 0.0638297872340425 0.0171428571428571
GO:BP GO:1904950 negative regulation of establishment of protein localization 0.0339458840766969 139 111 4 0.036036036036036 0.0287769784172662
GO:BP GO:0009888 tissue development 0.0339752903328836 2107 50 12 0.24 0.0056953013763645
GO:BP GO:0055001 muscle cell development 0.0342476748708807 184 45 3 0.0666666666666667 0.016304347826087
GO:BP GO:0003013 circulatory system process 0.0346579666606699 637 122 10 0.0819672131147541 0.0156985871271586
GO:BP GO:0015909 long-chain fatty acid transport 0.0347729961308549 75 111 3 0.027027027027027 0.04
GO:BP GO:0065007 biological regulation 0.0348192356695151 12809 13 13 1 0.0010149113904286
GO:BP GO:0045936 negative regulation of phosphate metabolic process 0.0351045838699969 543 16 3 0.1875 0.00552486187845304
GO:BP GO:0010563 negative regulation of phosphorus metabolic process 0.0351671251231589 544 16 3 0.1875 0.00551470588235294
GO:BP GO:0034341 response to interferon-gamma 0.0351671251231589 196 124 5 0.0403225806451613 0.0255102040816327
GO:BP GO:0010632 regulation of epithelial cell migration 0.0351975281944942 306 111 6 0.0540540540540541 0.0196078431372549
GO:BP GO:0003014 renal system process 0.0351975281944942 126 125 4 0.032 0.0317460317460317
GO:BP GO:0031175 neuron projection development 0.0351975281944942 1012 9 3 0.333333333333333 0.00296442687747036
GO:BP GO:0050778 positive regulation of immune response 0.0361521265967211 753 12 3 0.25 0.00398406374501992
GO:BP GO:0009891 positive regulation of biosynthetic process 0.0361745971834328 2004 9 4 0.444444444444444 0.00199600798403194
GO:BP GO:0061045 negative regulation of wound healing 0.0368637712054519 78 111 3 0.027027027027027 0.0384615384615385
GO:BP GO:0006814 sodium ion transport 0.0368637712054519 241 67 4 0.0597014925373134 0.016597510373444
GO:BP GO:0008015 blood circulation 0.0376057055598391 553 122 9 0.0737704918032787 0.0162748643761302
GO:BP GO:0031401 positive regulation of protein modification process 0.0378162240686508 1074 16 4 0.25 0.0037243947858473
GO:BP GO:0071241 cellular response to inorganic substance 0.0381193576111928 220 114 5 0.043859649122807 0.0227272727272727
GO:BP GO:0045595 regulation of cell differentiation 0.0383211884074747 1679 6 3 0.5 0.00178677784395473
GO:BP GO:0014070 response to organic cyclic compound 0.0385099357110126 967 71 9 0.126760563380282 0.0093071354705274
GO:BP GO:0007050 cell cycle arrest 0.0385314033450097 241 37 3 0.0810810810810811 0.012448132780083
GO:BP GO:0060341 regulation of cellular localization 0.0387488903807608 851 42 6 0.142857142857143 0.00705052878965922
GO:BP GO:0097746 blood vessel diameter maintenance 0.0389120735217187 135 122 4 0.0327868852459016 0.0296296296296296
GO:BP GO:0035296 regulation of tube diameter 0.0389120735217187 135 122 4 0.0327868852459016 0.0296296296296296
GO:BP GO:0040013 negative regulation of locomotion 0.0393881906617544 401 114 7 0.0614035087719298 0.0174563591022444
GO:BP GO:0030855 epithelial cell differentiation 0.0394409057195822 798 45 6 0.133333333333333 0.0075187969924812
GO:BP GO:0035150 regulation of tube size 0.0394409057195822 136 122 4 0.0327868852459016 0.0294117647058824
GO:BP GO:0008152 metabolic process 0.0403547273328236 11827 10 10 1 0.000845522955948254
GO:BP GO:0034614 cellular response to reactive oxygen species 0.0406310945428795 170 54 3 0.0555555555555556 0.0176470588235294
GO:BP GO:1904705 regulation of vascular associated smooth muscle cell proliferation 0.0406310945428795 88 104 3 0.0288461538461538 0.0340909090909091
GO:BP GO:1990874 vascular associated smooth muscle cell proliferation 0.0406310945428795 88 104 3 0.0288461538461538 0.0340909090909091
GO:BP GO:0045216 cell-cell junction organization 0.0411554564294141 216 120 5 0.0416666666666667 0.0231481481481481
GO:BP GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0411554564294141 81 114 3 0.0263157894736842 0.037037037037037
GO:BP GO:0030036 actin cytoskeleton organization 0.0412323767774064 709 98 9 0.0918367346938776 0.0126939351198872
GO:BP GO:0045834 positive regulation of lipid metabolic process 0.041325125472853 155 60 3 0.05 0.0193548387096774
GO:BP GO:1905477 positive regulation of protein localization to membrane 0.041325125472853 131 71 3 0.0422535211267606 0.0229007633587786
GO:BP GO:0048660 regulation of smooth muscle cell proliferation 0.041990021190084 174 54 3 0.0555555555555556 0.0172413793103448
GO:BP GO:0071495 cellular response to endogenous stimulus 0.0422235938249518 1422 13 4 0.307692307692308 0.00281293952180028
GO:BP GO:0019730 antimicrobial humoral response 0.0426081705101272 145 119 4 0.0336134453781513 0.0275862068965517
GO:BP GO:0048659 smooth muscle cell proliferation 0.0429743037298357 176 54 3 0.0555555555555556 0.0170454545454545
GO:BP GO:0019915 lipid storage 0.0436374715110132 86 111 3 0.027027027027027 0.0348837209302326
GO:BP GO:0048666 neuron development 0.0440136415048677 1149 9 3 0.333333333333333 0.00261096605744125
GO:BP GO:0097529 myeloid leukocyte migration 0.0448620653950368 221 121 5 0.0413223140495868 0.0226244343891403
GO:BP GO:0006807 nitrogen compound metabolic process 0.0448784055810712 10078 7 7 1 0.0006945822583846
GO:BP GO:0007568 aging 0.0450387375017316 329 54 4 0.0740740740740741 0.0121580547112462
GO:BP GO:0010660 regulation of muscle cell apoptotic process 0.0456020875131024 94 104 3 0.0288461538461538 0.0319148936170213
GO:BP GO:0006355 regulation of transcription, DNA-templated 0.0460759796916402 3534 12 6 0.5 0.00169779286926995
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 0.0460990591872463 3535 12 6 0.5 0.0016973125884017
GO:BP GO:0006954 inflammatory response 0.0462285494248846 794 121 11 0.0909090909090909 0.0138539042821159
GO:BP GO:2001141 regulation of RNA biosynthetic process 0.0463109364216615 3540 12 6 0.5 0.00169491525423729
GO:BP GO:0043535 regulation of blood vessel endothelial cell migration 0.0468842118911082 162 111 4 0.036036036036036 0.0246913580246914
GO:BP GO:0016070 RNA metabolic process 0.0470292211908472 4710 12 7 0.583333333333333 0.00148619957537155
GO:BP GO:0048513 animal organ development 0.0470903599556139 3672 6 4 0.666666666666667 0.00108932461873638
GO:BP GO:0060326 cell chemotaxis 0.0471055852879395 310 121 6 0.0495867768595041 0.0193548387096774
GO:BP GO:0031424 keratinization 0.0475298742020834 224 45 3 0.0666666666666667 0.0133928571428571
GO:BP GO:0002690 positive regulation of leukocyte chemotaxis 0.0476463276966881 93 108 3 0.0277777777777778 0.032258064516129
GO:BP GO:0030595 leukocyte chemotaxis 0.0477516710823583 227 121 5 0.0413223140495868 0.0220264317180617
GO:BP GO:0032496 response to lipopolysaccharide 0.0483292093702297 338 112 6 0.0535714285714286 0.0177514792899408
GO:BP GO:2000117 negative regulation of cysteine-type endopeptidase activity 0.0485105279301529 89 114 3 0.0263157894736842 0.0337078651685393
GO:BP GO:0098609 cell-cell adhesion 0.0486361002970192 894 12 3 0.25 0.00335570469798658
GO:BP GO:0010657 muscle cell apoptotic process 0.0486361002970192 98 104 3 0.0288461538461538 0.0306122448979592
GO:BP GO:0098542 defense response to other organism 0.0494094657198063 1218 124 15 0.120967741935484 0.0123152709359606
GO:CC GO:1903561 extracellular vesicle 1.32552564689179e-11 2261 14 14 1 0.00619195046439629
GO:CC GO:0070062 extracellular exosome 1.32552564689179e-11 2176 14 14 1 0.00643382352941176
GO:CC GO:0043230 extracellular organelle 1.32552564689179e-11 2263 14 14 1 0.00618647812638091
GO:CC GO:0005615 extracellular space 6.55310714091256e-09 3594 14 14 1 0.00389538119087368
GO:CC GO:1904813 ficolin-1-rich granule lumen 1.3012172280312e-08 124 25 7 0.28 0.0564516129032258
GO:CC GO:0031982 vesicle 2.37349383544261e-08 4055 14 14 1 0.00345252774352651
GO:CC GO:0005576 extracellular region 9.4298859581238e-08 4567 14 14 1 0.00306546967374644
GO:CC GO:0101002 ficolin-1-rich granule 9.4298859581238e-08 184 14 6 0.428571428571429 0.0326086956521739
GO:CC GO:0008180 COP9 signalosome 3.69468457873696e-07 35 14 4 0.285714285714286 0.114285714285714
GO:CC GO:0016327 apicolateral plasma membrane 6.87923898611542e-06 22 117 5 0.0427350427350427 0.227272727272727
GO:CC GO:0005829 cytosol 1.37674676422035e-05 5303 52 32 0.615384615384615 0.00603432019611541
GO:CC GO:0097708 intracellular vesicle 1.90026703782932e-05 2428 14 10 0.714285714285714 0.00411861614497529
GO:CC GO:0031410 cytoplasmic vesicle 1.90026703782932e-05 2424 14 10 0.714285714285714 0.00412541254125413
GO:CC GO:0030141 secretory granule 2.3028689077152e-05 851 14 7 0.5 0.0082256169212691
GO:CC GO:0016234 inclusion body 2.83078822418453e-05 76 6 3 0.5 0.0394736842105263
GO:CC GO:0005925 focal adhesion 4.66210948409153e-05 420 11 5 0.454545454545455 0.0119047619047619
GO:CC GO:0030055 cell-substrate junction 4.758854021866e-05 427 11 5 0.454545454545455 0.0117096018735363
GO:CC GO:0072562 blood microparticle 5.17354167150027e-05 140 14 4 0.285714285714286 0.0285714285714286
GO:CC GO:0099503 secretory vesicle 5.17587422787708e-05 1020 14 7 0.5 0.00686274509803922
GO:CC GO:0005739 mitochondrion 5.17587422787708e-05 1673 13 8 0.615384615384615 0.00478182904961148
GO:CC GO:0048471 perinuclear region of cytoplasm 7.10592997109061e-05 735 13 6 0.461538461538462 0.00816326530612245
GO:CC GO:0042470 melanosome 0.000246730464306968 105 10 3 0.3 0.0285714285714286
GO:CC GO:0048770 pigment granule 0.000246730464306968 105 10 3 0.3 0.0285714285714286
GO:CC GO:0043005 neuron projection 0.000295659305042389 1380 10 6 0.6 0.00434782608695652
GO:CC GO:0101031 chaperone complex 0.000339912643073448 27 42 3 0.0714285714285714 0.111111111111111
GO:CC GO:0036477 somatodendritic compartment 0.000454317771190883 871 10 5 0.5 0.00574052812858783
GO:CC GO:0030018 Z disc 0.000589498389760899 126 63 5 0.0793650793650794 0.0396825396825397
GO:CC GO:0043233 organelle lumen 0.000589498389760899 5565 38 23 0.605263157894737 0.0041329739442947
GO:CC GO:0070161 anchoring junction 0.000589498389760899 836 11 5 0.454545454545455 0.00598086124401914
GO:CC GO:0043025 neuronal cell body 0.000589498389760899 518 9 4 0.444444444444444 0.00772200772200772
GO:CC GO:0031974 membrane-enclosed lumen 0.000589498389760899 5565 38 23 0.605263157894737 0.0041329739442947
GO:CC GO:0034774 secretory granule lumen 0.000634992124619776 320 14 4 0.285714285714286 0.0125
GO:CC GO:0031983 vesicle lumen 0.000648342224070691 326 14 4 0.285714285714286 0.0122699386503067
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.000648342224070691 324 14 4 0.285714285714286 0.0123456790123457
GO:CC GO:0042588 zymogen granule 0.000704071396907005 14 119 3 0.0252100840336134 0.214285714285714
GO:CC GO:0042995 cell projection 0.000726182194746636 2330 11 7 0.636363636363636 0.00300429184549356
GO:CC GO:0070013 intracellular organelle lumen 0.000737032543372199 5402 10 9 0.9 0.00166604961125509
GO:CC GO:0031674 I band 0.000774012431670169 139 63 5 0.0793650793650794 0.0359712230215827
GO:CC GO:0044297 cell body 0.000804344315102834 592 9 4 0.444444444444444 0.00675675675675676
GO:CC GO:0005737 cytoplasm 0.00101583899135444 11911 25 24 0.96 0.00201494416925531
GO:CC GO:0005654 nucleoplasm 0.00101583899135444 4102 10 8 0.8 0.00195026816187226
GO:CC GO:0005814 centriole 0.00101583899135444 142 14 3 0.214285714285714 0.0211267605633803
GO:CC GO:0031907 microbody lumen 0.00112355382777002 53 38 3 0.0789473684210526 0.0566037735849057
GO:CC GO:0005782 peroxisomal matrix 0.00112355382777002 53 38 3 0.0789473684210526 0.0566037735849057
GO:CC GO:0015630 microtubule cytoskeleton 0.0013345806583847 1307 14 6 0.428571428571429 0.00459066564651875
GO:CC GO:0097447 dendritic tree 0.00149881291259353 640 10 4 0.4 0.00625
GO:CC GO:0030425 dendrite 0.00149881291259353 638 10 4 0.4 0.00626959247648903
GO:CC GO:0030424 axon 0.00162552140731869 660 10 4 0.4 0.00606060606060606
GO:CC GO:0031981 nuclear lumen 0.00162552140731869 4444 10 8 0.8 0.0018001800180018
GO:CC GO:0012505 endomembrane system 0.00173930171338866 4640 14 10 0.714285714285714 0.0021551724137931
GO:CC GO:0030139 endocytic vesicle 0.00194093522203846 306 9 3 0.333333333333333 0.00980392156862745
GO:CC GO:0120025 plasma membrane bounded cell projection 0.00211892165677872 2229 10 6 0.6 0.00269179004037685
GO:CC GO:0005634 nucleus 0.00262287821664762 7592 17 14 0.823529411764706 0.00184404636459431
GO:CC GO:0150034 distal axon 0.00265504158383539 308 10 3 0.3 0.00974025974025974
GO:CC GO:0030054 cell junction 0.00292065184551518 2105 11 6 0.545454545454545 0.00285035629453682
GO:CC GO:0030017 sarcomere 0.0034334073828015 208 63 5 0.0793650793650794 0.0240384615384615
GO:CC GO:0005856 cytoskeleton 0.00350293425614714 2332 14 7 0.5 0.00300171526586621
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.00370959031898348 11296 14 14 1 0.00123937677053824
GO:CC GO:0016328 lateral plasma membrane 0.0042095301878703 68 117 4 0.0341880341880342 0.0588235294117647
GO:CC GO:0043202 lysosomal lumen 0.0042095301878703 97 36 3 0.0833333333333333 0.0309278350515464
GO:CC GO:0098590 plasma membrane region 0.00463192807332368 1240 122 18 0.147540983606557 0.0145161290322581
GO:CC GO:0030016 myofibril 0.00482073957770633 231 63 5 0.0793650793650794 0.0216450216450216
GO:CC GO:0043292 contractile fiber 0.00556140232866662 240 63 5 0.0793650793650794 0.0208333333333333
GO:CC GO:0140513 nuclear protein-containing complex 0.00659252773747063 1249 14 5 0.357142857142857 0.00400320256204964
GO:CC GO:0005886 plasma membrane 0.00710152410099217 5681 14 10 0.714285714285714 0.00176025347650062
GO:CC GO:0005741 mitochondrial outer membrane 0.0104684990159741 202 128 6 0.046875 0.0297029702970297
GO:CC GO:0005768 endosome 0.010630281734062 987 12 4 0.333333333333333 0.00405268490374873
GO:CC GO:0005777 peroxisome 0.0112948518733819 141 38 3 0.0789473684210526 0.0212765957446809
GO:CC GO:0042579 microbody 0.0112948518733819 141 38 3 0.0789473684210526 0.0212765957446809
GO:CC GO:0043229 intracellular organelle 0.0115106790303873 12491 14 14 1 0.00112080698102634
GO:CC GO:0071944 cell periphery 0.0118592525085687 6169 12 9 0.75 0.00145890744042795
GO:CC GO:0043227 membrane-bounded organelle 0.0150237224122065 12858 14 14 1 0.00108881630113548
GO:CC GO:0031968 organelle outer membrane 0.0152512895314783 227 128 6 0.046875 0.026431718061674
GO:CC GO:0019867 outer membrane 0.0157553259757617 229 128 6 0.046875 0.0262008733624454
GO:CC GO:0000323 lytic vacuole 0.0170048009743243 712 10 3 0.3 0.00421348314606742
GO:CC GO:0005764 lysosome 0.0170048009743243 712 10 3 0.3 0.00421348314606742
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 0.0170048009743243 5338 14 9 0.642857142857143 0.00168602472836268
GO:CC GO:0043228 non-membrane-bounded organelle 0.0170321010895846 5346 14 9 0.642857142857143 0.00168350168350168
GO:CC GO:0045177 apical part of cell 0.020544382920574 431 122 8 0.0655737704918033 0.0185614849187935
GO:CC GO:0032991 protein-containing complex 0.0207735575256611 5548 14 9 0.642857142857143 0.00162220620043259
GO:CC GO:0005923 bicellular tight junction 0.0212341542170526 123 117 4 0.0341880341880342 0.032520325203252
GO:CC GO:0005773 vacuole 0.022003008554202 810 10 3 0.3 0.0037037037037037
GO:CC GO:0005783 endoplasmic reticulum 0.022826261531784 1982 13 5 0.384615384615385 0.00252270433905146
GO:CC GO:0070160 tight junction 0.0257317472279771 131 117 4 0.0341880341880342 0.0305343511450382
GO:CC GO:0016020 membrane 0.0269839375848815 9838 14 12 0.857142857142857 0.00121976011384428
GO:CC GO:0043296 apical junction complex 0.0337667518833877 145 117 4 0.0341880341880342 0.0275862068965517
GO:CC GO:0043226 organelle 0.0376534106482641 14008 14 14 1 0.000999428897772701
GO:CC GO:0005882 intermediate filament 0.0385310410776143 218 45 3 0.0666666666666667 0.0137614678899083
GO:CC GO:0005622 intracellular anatomical structure 0.0412504897160022 14790 25 24 0.96 0.00162271805273834
GO:CC GO:0009986 cell surface 0.0418881875206836 899 12 3 0.25 0.00333704115684093
GO:MF GO:0051082 unfolded protein binding 6.91691832073282e-18 112 19 11 0.578947368421053 0.0982142857142857
GO:MF GO:0044183 protein folding chaperone 4.18104127757439e-17 35 14 8 0.571428571428571 0.228571428571429
GO:MF GO:0031625 ubiquitin protein ligase binding 1.52106666434501e-11 296 14 9 0.642857142857143 0.0304054054054054
GO:MF GO:0044389 ubiquitin-like protein ligase binding 1.94592231367532e-11 314 14 9 0.642857142857143 0.0286624203821656
GO:MF GO:0031072 heat shock protein binding 1.54030881512957e-10 127 14 7 0.5 0.0551181102362205
GO:MF GO:0055131 C3HC4-type RING finger domain binding 1.54030881512957e-10 6 13 4 0.307692307692308 0.666666666666667
GO:MF GO:0051087 chaperone binding 3.81659100441755e-09 103 63 9 0.142857142857143 0.087378640776699
GO:MF GO:0019899 enzyme binding 1.37095111537091e-08 2074 14 12 0.857142857142857 0.00578592092574735
GO:MF GO:0035639 purine ribonucleoside triphosphate binding 1.14720736105754e-07 1847 14 11 0.785714285714286 0.00595560368164591
GO:MF GO:0017076 purine nucleotide binding 1.34568466147473e-07 1933 14 11 0.785714285714286 0.00569063631660631
GO:MF GO:0032555 purine ribonucleotide binding 1.34568466147473e-07 1918 14 11 0.785714285714286 0.00573514077163712
GO:MF GO:0032553 ribonucleotide binding 1.34568466147473e-07 1935 14 11 0.785714285714286 0.00568475452196382
GO:MF GO:0051787 misfolded protein binding 1.34568466147473e-07 28 14 4 0.285714285714286 0.142857142857143
GO:MF GO:0060590 ATPase regulator activity 2.30145189944945e-07 44 63 6 0.0952380952380952 0.136363636363636
GO:MF GO:0005524 ATP binding 2.36022585949839e-07 1501 14 10 0.714285714285714 0.00666222518321119
GO:MF GO:0030554 adenyl nucleotide binding 3.07874310039338e-07 1578 14 10 0.714285714285714 0.00633713561470215
GO:MF GO:0032559 adenyl ribonucleotide binding 3.07874310039338e-07 1565 14 10 0.714285714285714 0.00638977635782748
GO:MF GO:1901265 nucleoside phosphate binding 3.07874310039338e-07 2172 14 11 0.785714285714286 0.00506445672191529
GO:MF GO:0000166 nucleotide binding 3.07874310039338e-07 2171 14 11 0.785714285714286 0.00506678949792722
GO:MF GO:0042826 histone deacetylase binding 4.58678259644181e-07 116 6 4 0.666666666666667 0.0344827586206897
GO:MF GO:0097367 carbohydrate derivative binding 4.78238577450244e-07 2285 14 11 0.785714285714286 0.00481400437636762
GO:MF GO:0043168 anion binding 8.33091672817494e-07 2418 14 11 0.785714285714286 0.00454921422663358
GO:MF GO:0036094 small molecule binding 1.16444855621379e-06 2506 14 11 0.785714285714286 0.00438946528332003
GO:MF GO:0023026 MHC class II protein complex binding 1.36338908115523e-06 17 10 3 0.3 0.176470588235294
GO:MF GO:0097718 disordered domain specific binding 1.92003544539422e-06 34 6 3 0.5 0.0882352941176471
GO:MF GO:0023023 MHC protein complex binding 4.24716612416704e-06 25 10 3 0.3 0.12
GO:MF GO:0016887 ATPase activity 1.25547933974512e-05 488 14 6 0.428571428571429 0.0122950819672131
GO:MF GO:0017111 nucleoside-triphosphatase activity 1.89639257973602e-05 872 14 7 0.5 0.00802752293577982
GO:MF GO:0001671 ATPase activator activity 2.1248189620822e-05 25 63 4 0.0634920634920635 0.16
GO:MF GO:0016462 pyrophosphatase activity 2.49901944098554e-05 928 14 7 0.5 0.00754310344827586
GO:MF GO:0098772 molecular function regulator 2.49901944098554e-05 2363 69 24 0.347826086956522 0.0101565806178587
GO:MF GO:0016817 hydrolase activity, acting on acid anhydrides 2.49901944098554e-05 930 14 7 0.5 0.00752688172043011
GO:MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.49901944098554e-05 930 14 7 0.5 0.00752688172043011
GO:MF GO:0019904 protein domain specific binding 4.89793420460536e-05 710 13 6 0.461538461538462 0.00845070422535211
GO:MF GO:0003723 RNA binding 5.38505527984669e-05 1943 12 8 0.666666666666667 0.00411734431291817
GO:MF GO:0045296 cadherin binding 9.7620692622552e-05 333 42 7 0.166666666666667 0.021021021021021
GO:MF GO:0001664 G protein-coupled receptor binding 0.000409135110091115 292 13 4 0.307692307692308 0.0136986301369863
GO:MF GO:0030234 enzyme regulator activity 0.000560061534048252 1248 48 12 0.25 0.00961538461538462
GO:MF GO:1901363 heterocyclic compound binding 0.000815090733560153 6228 14 12 0.857142857142857 0.00192678227360308
GO:MF GO:0050839 cell adhesion molecule binding 0.000842666415869189 546 78 10 0.128205128205128 0.0183150183150183
GO:MF GO:0097159 organic cyclic compound binding 0.000880934239771944 6309 14 12 0.857142857142857 0.0019020446980504
GO:MF GO:0097110 scaffold protein binding 0.00133495635642335 59 33 3 0.0909090909090909 0.0508474576271186
GO:MF GO:0016209 antioxidant activity 0.00151811023656161 87 112 5 0.0446428571428571 0.0574712643678161
GO:MF GO:0019901 protein kinase binding 0.00357873665506796 673 11 4 0.363636363636364 0.00594353640416048
GO:MF GO:0044877 protein-containing complex binding 0.00382496792024098 1287 50 11 0.22 0.00854700854700855
GO:MF GO:0043167 ion binding 0.00403431289281236 6057 14 11 0.785714285714286 0.00181608056793792
GO:MF GO:0019900 kinase binding 0.00468387541154811 752 11 4 0.363636363636364 0.00531914893617021
GO:MF GO:0005515 protein binding 0.00512052460287419 14767 50 48 0.96 0.00325049095957202
GO:MF GO:0003676 nucleic acid binding 0.00512052460287419 4276 7 6 0.857142857142857 0.00140318054256314
GO:MF GO:0042803 protein homodimerization activity 0.00543130973286149 676 6 3 0.5 0.00443786982248521
GO:MF GO:0005102 signaling receptor binding 0.0061142157651396 1672 121 22 0.181818181818182 0.0131578947368421
GO:MF GO:0044325 ion channel binding 0.00626044593861921 135 28 3 0.107142857142857 0.0222222222222222
GO:MF GO:0004857 enzyme inhibitor activity 0.00695622645085392 385 58 6 0.103448275862069 0.0155844155844156
GO:MF GO:0042379 chemokine receptor binding 0.00696882083055329 72 121 4 0.0330578512396694 0.0555555555555556
GO:MF GO:0016787 hydrolase activity 0.00793887489529293 2615 14 7 0.5 0.00267686424474187
GO:MF GO:0060589 nucleoside-triphosphatase regulator activity 0.00921002384399452 530 19 4 0.210526315789474 0.00754716981132075
GO:MF GO:0099106 ion channel regulator activity 0.0127394277479155 120 44 3 0.0681818181818182 0.025
GO:MF GO:0046983 protein dimerization activity 0.0139240048059714 1069 6 3 0.5 0.00280636108512629
GO:MF GO:0008009 chemokine activity 0.0159171745245261 49 121 3 0.0247933884297521 0.0612244897959184
GO:MF GO:0016247 channel regulator activity 0.0204263139274257 149 44 3 0.0681818181818182 0.0201342281879195
GO:MF GO:0015459 potassium channel regulator activity 0.020652243520279 54 122 3 0.0245901639344262 0.0555555555555556
GO:MF GO:0008047 enzyme activator activity 0.0231040329739333 540 115 9 0.0782608695652174 0.0166666666666667
GO:MF GO:0008092 cytoskeletal protein binding 0.0246863819628247 996 8 3 0.375 0.00301204819277108
GO:MF GO:0042277 peptide binding 0.0278871527495739 314 25 3 0.12 0.00955414012738853
GO:MF GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 0.0281010614520451 281 28 3 0.107142857142857 0.0106761565836299
GO:MF GO:0004866 endopeptidase inhibitor activity 0.0332708486029803 176 48 3 0.0625 0.0170454545454545
GO:MF GO:0030414 peptidase inhibitor activity 0.0358961489017349 182 48 3 0.0625 0.0164835164835165
GO:MF GO:0061135 endopeptidase regulator activity 0.0378049248086096 188 48 3 0.0625 0.0159574468085106
GO:MF GO:0042802 identical protein binding 0.0410586536899037 2067 122 22 0.180327868852459 0.0106434446057088
GO:MF GO:0033218 amide binding 0.041380152204084 389 25 3 0.12 0.0077120822622108
GO:MF GO:0048018 receptor ligand activity 0.041856653527236 494 121 8 0.0661157024793388 0.0161943319838057
GO:MF GO:0048306 calcium-dependent protein binding 0.0426264462270927 82 119 3 0.0252100840336134 0.0365853658536585
GO:MF GO:0030546 signaling receptor activator activity 0.0442161748327455 501 121 8 0.0661157024793388 0.0159680638722555
GO:MF GO:0001540 amyloid-beta binding 0.0458672767871933 83 122 3 0.0245901639344262 0.036144578313253
GO:MF GO:0072341 modified amino acid binding 0.0473045615722297 91 114 3 0.0263157894736842 0.032967032967033
HPA HPA:0060103 bronchus; respiratory epithelial cells[High] 0.0205675661257107 1890 9 7 0.777777777777778 0.0037037037037037
HPA HPA:0210053 fallopian tube; glandular cells[High] 0.0205675661257107 1728 45 18 0.4 0.0104166666666667
HPA HPA:0340462 ovary; ovarian stroma cells[≥Medium] 0.0205675661257107 2002 9 7 0.777777777777778 0.0034965034965035
HPA HPA:0381203 placenta; hofbauer cells[High] 0.0205675661257107 153 37 5 0.135135135135135 0.0326797385620915
HPA HPA:0390053 prostate; glandular cells[High] 0.0356244306067565 1284 40 13 0.325 0.0101246105919003
HPA HPA:0110223 cervix, uterine; squamous epithelial cells[High] 0.0356244306067565 986 13 6 0.461538461538462 0.00608519269776876
HPA HPA:0170052 endometrium 2; glandular cells[≥Medium] 0.0356244306067565 4758 45 31 0.688888888888889 0.00651534258091635
HPA HPA:0381202 placenta; hofbauer cells[≥Medium] 0.0356244306067565 213 37 5 0.135135135135135 0.0234741784037559
HPA HPA:0190223 esophagus; squamous epithelial cells[High] 0.0356244306067565 1596 9 6 0.666666666666667 0.0037593984962406
HPA HPA:0160053 endometrium 1; glandular cells[High] 0.0423654069114038 1413 45 14 0.311111111111111 0.00990799716914367
HPA HPA:0110053 cervix, uterine; glandular cells[High] 0.0423654069114038 1135 45 12 0.266666666666667 0.0105726872246696
HPA HPA:0100123 cerebral cortex; glial cells[High] 0.0423654069114038 683 21 6 0.285714285714286 0.00878477306002928
HPA HPA:0291162 liver; cholangiocytes[≥Medium] 0.0423654069114038 1910 9 6 0.666666666666667 0.0031413612565445
HPA HPA:0030053 appendix; glandular cells[High] 0.0423654069114038 1986 45 17 0.377777777777778 0.00855991943605237
HPA HPA:0291163 liver; cholangiocytes[High] 0.0423654069114038 294 120 10 0.0833333333333333 0.0340136054421769
HPA HPA:0381201 placenta; hofbauer cells[≥Low] 0.0423654069114038 254 37 5 0.135135135135135 0.0196850393700787
HPA HPA:0500113 soft tissue 1; chondrocytes[High] 0.0423654069114038 296 17 4 0.235294117647059 0.0135135135135135
HPA HPA:0570763 testis; pachytene spermatocytes[High] 0.0423654069114038 822 4 3 0.75 0.00364963503649635
HPA HPA:0610833 urinary bladder; urothelial cells[High] 0.0423654069114038 1969 9 6 0.666666666666667 0.00304723209751143
HPA HPA:0030052 appendix; glandular cells[≥Medium] 0.043109328332074 5767 45 34 0.755555555555556 0.00589561297034853
KEGG KEGG:04141 Protein processing in endoplasmic reticulum 2.05019138472654e-10 170 14 9 0.642857142857143 0.0529411764705882
KEGG KEGG:04612 Antigen processing and presentation 7.36038213528973e-08 69 14 6 0.428571428571429 0.0869565217391304
KEGG KEGG:05134 Legionellosis 1.530817277466e-06 57 14 5 0.357142857142857 0.087719298245614
KEGG KEGG:04915 Estrogen signaling pathway 2.3788043555177e-06 137 14 6 0.428571428571429 0.0437956204379562
KEGG KEGG:04213 Longevity regulating pathway - multiple species 9.69574605791275e-05 62 14 4 0.285714285714286 0.0645161290322581
KEGG KEGG:04010 MAPK signaling pathway 0.000359047576411822 294 16 6 0.375 0.0204081632653061
KEGG KEGG:05145 Toxoplasmosis 0.00065877301753291 109 14 4 0.285714285714286 0.036697247706422
KEGG KEGG:05162 Measles 0.00149699576034353 139 14 4 0.285714285714286 0.0287769784172662
KEGG KEGG:03040 Spliceosome 0.00179039333613648 150 14 4 0.285714285714286 0.0266666666666667
KEGG KEGG:04144 Endocytosis 0.0117672604979953 252 14 4 0.285714285714286 0.0158730158730159
KEGG KEGG:05020 Prion disease 0.0144497861457589 273 14 4 0.285714285714286 0.0146520146520147
KEGG KEGG:05132 Salmonella infection 0.0390971020643334 249 11 3 0.272727272727273 0.0120481927710843
MIRNA MIRNA:hsa-miR-365b-3p hsa-miR-365b-3p 0.000293128726377975 86 44 6 0.136363636363636 0.0697674418604651
MIRNA MIRNA:hsa-miR-365a-3p hsa-miR-365a-3p 0.00122106365208102 123 44 6 0.136363636363636 0.0487804878048781
MIRNA MIRNA:hsa-miR-16-5p hsa-miR-16-5p 0.00592639991509791 1556 13 8 0.615384615384615 0.0051413881748072
MIRNA MIRNA:hsa-miR-7-1-3p hsa-miR-7-1-3p 0.0182889694390662 180 19 4 0.210526315789474 0.0222222222222222
MIRNA MIRNA:hsa-miR-1226-3p hsa-miR-1226-3p 0.0182889694390662 226 6 3 0.5 0.0132743362831858
MIRNA MIRNA:hsa-miR-7-2-3p hsa-miR-7-2-3p 0.0182889694390662 167 19 4 0.210526315789474 0.0239520958083832
MIRNA MIRNA:hsa-miR-486-3p hsa-miR-486-3p 0.0259129655801782 201 37 5 0.135135135135135 0.0248756218905473
MIRNA MIRNA:hsa-miR-10a-5p hsa-miR-10a-5p 0.0259129655801782 461 4 3 0.75 0.00650759219088937
MIRNA MIRNA:hsa-miR-7162-3p hsa-miR-7162-3p 0.0337771370947406 173 54 5 0.0925925925925926 0.0289017341040462
MIRNA MIRNA:hsa-miR-582-5p hsa-miR-582-5p 0.0337771370947406 149 37 4 0.108108108108108 0.0268456375838926
MIRNA MIRNA:hsa-miR-5697 hsa-miR-5697 0.0337771370947406 171 83 6 0.072289156626506 0.0350877192982456
MIRNA MIRNA:hsa-miR-4500 hsa-miR-4500 0.0337771370947406 310 85 8 0.0941176470588235 0.0258064516129032
MIRNA MIRNA:hsa-miR-4458 hsa-miR-4458 0.0337771370947406 310 85 8 0.0941176470588235 0.0258064516129032
MIRNA MIRNA:hsa-miR-4641 hsa-miR-4641 0.0337771370947406 52 44 3 0.0681818181818182 0.0576923076923077
MIRNA MIRNA:hsa-miR-499b-5p hsa-miR-499b-5p 0.03881179975006 73 34 3 0.0882352941176471 0.0410958904109589
MIRNA MIRNA:hsa-let-7i-5p hsa-let-7i-5p 0.03881179975006 332 85 8 0.0941176470588235 0.0240963855421687
MIRNA MIRNA:hsa-miR-4465 hsa-miR-4465 0.0407200166208896 190 83 6 0.072289156626506 0.0315789473684211
MIRNA MIRNA:hsa-let-7g-5p hsa-let-7g-5p 0.0411877588755336 339 85 8 0.0941176470588235 0.023598820058997
MIRNA MIRNA:hsa-miR-1297 hsa-miR-1297 0.0421644713606497 194 83 6 0.072289156626506 0.0309278350515464
MIRNA MIRNA:hsa-miR-4724-5p hsa-miR-4724-5p 0.0424990181844806 98 63 4 0.0634920634920635 0.0408163265306122
MIRNA MIRNA:hsa-miR-655-5p hsa-miR-655-5p 0.0442358309642583 122 23 3 0.130434782608696 0.0245901639344262
REAC REAC:R-HSA-3371568 Attenuation phase 2.29836042935681e-13 14 10 6 0.6 0.428571428571429
REAC REAC:R-HSA-3371571 HSF1-dependent transactivation 5.13393372477066e-12 24 10 6 0.6 0.25
REAC REAC:R-HSA-3371556 Cellular response to heat stress 1.03571189601516e-11 87 14 8 0.571428571428571 0.0919540229885057
REAC REAC:R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) 2.6853923645161e-11 57 13 7 0.538461538461538 0.12280701754386
REAC REAC:R-HSA-2262752 Cellular responses to stress 1.47899453858842e-08 546 14 10 0.714285714285714 0.0183150183150183
REAC REAC:R-HSA-3371453 Regulation of HSF1-mediated heat shock response 1.50335602753426e-08 67 14 6 0.428571428571429 0.0895522388059701
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 1.50335602753426e-08 560 14 10 0.714285714285714 0.0178571428571429
REAC REAC:R-HSA-9613829 Chaperone Mediated Autophagy 2.57627042145936e-07 22 10 4 0.4 0.181818181818182
REAC REAC:R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 9.75691909570848e-06 54 10 4 0.4 0.0740740740740741
REAC REAC:R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 5.81073157513416e-05 86 10 4 0.4 0.0465116279069767
REAC REAC:R-HSA-9612973 Autophagy 0.000404016031502256 149 10 4 0.4 0.0268456375838926
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.000824511918765923 474 14 6 0.428571428571429 0.0126582278481013
REAC REAC:R-HSA-373755 Semaphorin interactions 0.00131480591822463 64 11 3 0.272727272727273 0.046875
REAC REAC:R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.00131480591822463 79 9 3 0.333333333333333 0.0379746835443038
REAC REAC:R-HSA-5687128 MAPK6/MAPK4 signaling 0.00169088920825373 89 9 3 0.333333333333333 0.0337078651685393
REAC REAC:R-HSA-9663891 Selective autophagy 0.00169088920825373 80 10 3 0.3 0.0375
REAC REAC:R-HSA-5661231 Metallothioneins bind metals 0.00253803258234467 11 84 3 0.0357142857142857 0.272727272727273
REAC REAC:R-HSA-8939211 ESR-mediated signaling 0.00266771594843339 181 6 3 0.5 0.0165745856353591
REAC REAC:R-HSA-422475 Axon guidance 0.00357746569985389 549 11 5 0.454545454545455 0.00910746812386157
REAC REAC:R-HSA-168249 Innate Immune System 0.00386741119656421 1073 10 6 0.6 0.00559179869524697
REAC REAC:R-HSA-9675108 Nervous system development 0.00386741119656421 574 11 5 0.454545454545455 0.00871080139372822
REAC REAC:R-HSA-5660526 Response to metal ions 0.00386741119656421 14 84 3 0.0357142857142857 0.214285714285714
REAC REAC:R-HSA-1632852 Macroautophagy 0.00448807490493146 134 10 3 0.3 0.0223880597014925
REAC REAC:R-HSA-9006931 Signaling by Nuclear Receptors 0.00512288279019494 255 6 3 0.5 0.0117647058823529
REAC REAC:R-HSA-9018519 Estrogen-dependent gene expression 0.00550128047045861 112 89 6 0.0674157303370786 0.0535714285714286
REAC REAC:R-HSA-69275 G2/M Transition 0.00667860000774184 196 9 3 0.333333333333333 0.0153061224489796
REAC REAC:R-HSA-453274 Mitotic G2-G2/M phases 0.00674796823865548 198 9 3 0.333333333333333 0.0151515151515152
REAC REAC:R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.0121636299752449 76 108 5 0.0462962962962963 0.0657894736842105
REAC REAC:R-HSA-5683057 MAPK family signaling cascades 0.0180909152508579 308 9 3 0.333333333333333 0.00974025974025974
REAC REAC:R-HSA-977225 Amyloid fiber formation 0.0180909152508579 73 35 3 0.0857142857142857 0.0410958904109589
REAC REAC:R-HSA-5625740 RHO GTPases activate PKNs 0.0191485506840356 58 97 4 0.0412371134020619 0.0689655172413793
REAC REAC:R-HSA-8953854 Metabolism of RNA 0.0213493372217339 658 10 4 0.4 0.0060790273556231
REAC REAC:R-HSA-1266738 Developmental Biology 0.0249869535800123 1069 11 5 0.454545454545455 0.00467726847521048
REAC REAC:R-HSA-5653656 Vesicle-mediated transport 0.027147151227707 717 10 4 0.4 0.00557880055788006
REAC REAC:R-HSA-5663205 Infectious disease 0.0273222449029441 815 9 4 0.444444444444444 0.0049079754601227
REAC REAC:R-HSA-420029 Tight junction interactions 0.0351802433913726 30 117 3 0.0256410256410256 0.1
REAC REAC:R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.0435459375373745 35 111 3 0.027027027027027 0.0857142857142857
REAC REAC:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.0468838179603457 485 9 3 0.333333333333333 0.00618556701030928
REAC REAC:R-HSA-168256 Immune System 0.0470881010278746 2139 10 6 0.6 0.00280504908835905
REAC REAC:R-HSA-69278 Cell Cycle, Mitotic 0.047789083515518 513 9 3 0.333333333333333 0.00584795321637427
REAC REAC:R-HSA-449147 Signaling by Interleukins 0.047789083515518 446 10 3 0.3 0.00672645739910314
TF TF:M09950_1 Factor: HSF1; motif: NRGAANNTTCYRGAA; match class: 1 1.61134616510329e-17 266 14 12 0.857142857142857 0.0451127819548872
TF TF:M11656_1 Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1 4.90644178313991e-17 219 17 12 0.705882352941177 0.0547945205479452
TF TF:M11655_1 Factor: HSF1; motif: NGAANGTTCKRGAAN; match class: 1 1.3365436318409e-16 93 17 10 0.588235294117647 0.10752688172043
TF TF:M11655 Factor: HSF1; motif: NGAANGTTCKRGAAN 4.32820693652391e-15 1207 23 18 0.782608695652174 0.0149130074565037
TF TF:M11654_1 Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1 4.32820693652391e-15 113 13 9 0.692307692307692 0.079646017699115
TF TF:M07100_1 Factor: HSF1; motif: NTTCTRGAANNTTCY; match class: 1 8.03349606348914e-15 514 14 12 0.857142857142857 0.0233463035019455
TF TF:M01023_1 Factor: HSF1; motif: NTTCTRGAAVNTTCTYM; match class: 1 9.22235559816951e-14 254 14 10 0.714285714285714 0.0393700787401575
TF TF:M11654 Factor: HSF1; motif: RGAANRTTCYRGAAN 8.18395332807577e-13 1353 23 17 0.739130434782609 0.0125646711012565
TF TF:M11656 Factor: HSF1; motif: RGAANRTTCYRGAAN 2.32693182722324e-11 2033 23 18 0.782608695652174 0.0088539104771274
TF TF:M11662_1 Factor: HSF2; motif: RGAANGTTCYRGAAN; match class: 1 2.62534634815828e-11 12 13 5 0.384615384615385 0.416666666666667
TF TF:M11658 Factor: HSF4; motif: RGAANNTTCYRGAAN 2.97960517203762e-11 400 51 15 0.294117647058824 0.0375
TF TF:M11662 Factor: HSF2; motif: RGAANGTTCYRGAAN 6.30788050885371e-11 272 22 10 0.454545454545455 0.0367647058823529
TF TF:M11658_1 Factor: HSF4; motif: RGAANNTTCYRGAAN; match class: 1 1.82137096059808e-10 19 12 5 0.416666666666667 0.263157894736842
TF TF:M11659 Factor: HSF4; motif: NGAANRTTCTAGAAN 7.55423217367685e-10 329 51 13 0.254901960784314 0.0395136778115502
TF TF:M11657 Factor: HSF1; motif: NGAANRTTCKAGAAN 9.55156496741092e-10 337 51 13 0.254901960784314 0.0385756676557863
TF TF:M04008 Factor: HSF1; motif: TTCTAGAAYNTTC 1.9179047387116e-09 358 51 13 0.254901960784314 0.0363128491620112
TF TF:M07100 Factor: HSF1; motif: NTTCTRGAANNTTCY 3.18240158817386e-09 3350 25 20 0.8 0.00597014925373134
TF TF:M09950 Factor: HSF1; motif: NRGAANNTTCYRGAA 4.80243893122202e-09 2501 25 18 0.72 0.00719712115153938
TF TF:M11659_1 Factor: HSF4; motif: NGAANRTTCTAGAAN; match class: 1 2.39449461348962e-08 14 12 4 0.333333333333333 0.285714285714286
TF TF:M01023 Factor: HSF1; motif: NTTCTRGAAVNTTCTYM 2.39449461348962e-08 2721 14 13 0.928571428571429 0.0047776552737964
TF TF:M04008_1 Factor: HSF1; motif: TTCTAGAAYNTTC; match class: 1 2.39449461348962e-08 14 12 4 0.333333333333333 0.285714285714286
TF TF:M11657_1 Factor: HSF1; motif: NGAANRTTCKAGAAN; match class: 1 3.11578890881071e-08 15 12 4 0.333333333333333 0.266666666666667
TF TF:M04010 Factor: HSF4; motif: TTCTAGAANNTTC 2.4091065778711e-07 185 22 7 0.318181818181818 0.0378378378378378
TF TF:M01244_1 Factor: HSF2; motif: GAANRTTCTAGAA; match class: 1 2.63831632996704e-07 25 12 4 0.333333333333333 0.16
TF TF:M01244 Factor: HSF2; motif: GAANRTTCTAGAA 4.92361439173267e-07 582 51 13 0.254901960784314 0.0223367697594502
TF TF:M00147_1 Factor: HSF2; motif: NGAANNWTCK; match class: 1 6.34697239754348e-07 4404 48 30 0.625 0.00681198910081744
TF TF:M02017 Factor: HSF1; motif: GAANNTTCTRGNAN 1.46861413295595e-06 4046 42 26 0.619047619047619 0.00642609985170539
TF TF:M07459_1 Factor: HSF1; motif: GAANNTTCTNGN; match class: 1 6.24247491510488e-06 413 17 7 0.411764705882353 0.0169491525423729
TF TF:M00641 Factor: HSF; motif: TTCCMGARGYTTC 8.96873932327718e-06 3599 10 10 1 0.00277854959711031
TF TF:M07259_1 Factor: HSF1; motif: TCYAGAANNTTC; match class: 1 1.3391597970421e-05 732 17 8 0.470588235294118 0.0109289617486339
TF TF:M07358 Factor: HSF2; motif: NGGAATNTTCTNGNRN 1.78651561428991e-05 576 29 9 0.310344827586207 0.015625
TF TF:M00147 Factor: HSF2; motif: NGAANNWTCK 2.30809426033572e-05 5830 48 32 0.666666666666667 0.00548885077186964
TF TF:M02017_1 Factor: HSF1; motif: GAANNTTCTRGNAN; match class: 1 2.98413128026524e-05 543 42 10 0.238095238095238 0.0184162062615101
TF TF:M02107_1 Factor: NF-YC; motif: NRGCCAATYAGMGC; match class: 1 0.000372186021301547 58 9 3 0.333333333333333 0.0517241379310345
TF TF:M04001 Factor: GCM1; motif: NATGCGGGTAC 0.000372186021301547 388 12 5 0.416666666666667 0.0128865979381443
TF TF:M07222_1 Factor: NFYA; motif: AGNSYKCTGATTGGTNNR; match class: 1 0.000528253203184685 66 9 3 0.333333333333333 0.0454545454545455
TF TF:M08392_1 Factor: A-Myb:TBR2; motif: NNGTGNNNAACGG; match class: 1 0.000585416215846497 111 6 3 0.5 0.027027027027027
TF TF:M00144_1 Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM; match class: 1 0.002661907186767 7128 14 13 0.928571428571429 0.00182379349046016
TF TF:M12000_1 Factor: AML3; motif: NNAACCGCAAWAACCGCAAN; match class: 1 0.00286003912035849 1586 6 5 0.833333333333333 0.00315258511979823
TF TF:M07259 Factor: HSF1; motif: TCYAGAANNTTC 0.00300834570091262 4742 53 27 0.509433962264151 0.00569380008435259
TF TF:M02053 Factor: ELF1; motif: NCCGGAARTN 0.00340606669825347 6033 9 9 1 0.00149179512680259
TF TF:M08884 Factor: GCM; motif: NNNNATGMGGGN 0.0044519623464213 1185 12 6 0.5 0.00506329113924051
TF TF:M09732_1 Factor: RFX3; motif: NYNCCMTGGCAACM; match class: 1 0.0044519623464213 982 14 6 0.428571428571429 0.00610997963340122
TF TF:M11596 Factor: GCMb; motif: ATGCGGGYN 0.00624463977289265 737 12 5 0.416666666666667 0.0067842605156038
TF TF:M04002 Factor: GCMb; motif: NATGCGGGTN 0.00655092083546159 1282 12 6 0.5 0.0046801872074883
TF TF:M09600 Factor: CREB1; motif: TKACGTCAYNN 0.00684297520913874 5324 82 39 0.475609756097561 0.00732531930879038
TF TF:M11660 Factor: HSF2; motif: RGAAYRTTCYRGAAN 0.00684297520913874 66 22 3 0.136363636363636 0.0454545454545455
TF TF:M00146 Factor: HSF1; motif: AGAANRTTCN 0.00751400928842609 2678 46 17 0.369565217391304 0.00634802091112771
TF TF:M00287_1 Factor: NF-Y; motif: NNNRRCCAATSRGNNN; match class: 1 0.00794533432105727 184 9 3 0.333333333333333 0.016304347826087
TF TF:M02056 Factor: ELF4; motif: NCCGGAARTN 0.00987201419710738 5332 18 13 0.722222222222222 0.00243810952738185
TF TF:M08917 Factor: GABP-ALPHA; motif: RCCGGAARTNN 0.00987201419710738 2702 13 8 0.615384615384615 0.00296076980014804
TF TF:M07459 Factor: HSF1; motif: GAANNTTCTNGN 0.010930632111249 3422 49 20 0.408163265306122 0.00584453535943892
TF TF:M02106_1 Factor: NF-YA; motif: CRGCCAATCAGNRN; match class: 1 0.0120407036207465 217 9 3 0.333333333333333 0.0138248847926267
TF TF:M08980_1 Factor: VDR:RXR-ALPHA; motif: NRGGTCANNNGGTTCNN; match class: 1 0.0121605612705757 3939 110 39 0.354545454545455 0.0099009900990099
TF TF:M02102 Factor: NRF-1; motif: YGCGCMTGCGC 0.0127121952171194 2020 13 7 0.538461538461538 0.00346534653465347
TF TF:M05837 Factor: ZFP2; motif: NCCWCGGGRATA 0.013360010307545 188 51 5 0.0980392156862745 0.0265957446808511
TF TF:M08905_1 Factor: TIEG1; motif: GGSGGKGNNN; match class: 1 0.0137081322685867 1017 3 3 1 0.00294985250737463
TF TF:M08423 Factor: TEF-3:ER81; motif: ACCGGAAATRCC 0.0137081322685867 3845 13 9 0.692307692307692 0.0023407022106632
TF TF:M00955_1 Factor: GR; motif: NNNNNNNGKACNNNNTGTTCTNNNNNN; match class: 1 0.0137081322685867 754 8 4 0.5 0.00530503978779841
TF TF:M00641_1 Factor: HSF; motif: TTCCMGARGYTTC; match class: 1 0.0137417127857708 387 6 3 0.5 0.00775193798449612
TF TF:M03824 Factor: GCMb; motif: RCCCKCAT 0.0137417127857708 1550 12 6 0.5 0.00387096774193548
TF TF:M00650_1 Factor: MTF-1; motif: TBTGCACHCGGCCC; match class: 1 0.0137417127857708 24 84 3 0.0357142857142857 0.125
TF TF:M10635_1 Factor: Nkx2-3; motif: GNCGTTRAG; match class: 1 0.0163520331486525 703 9 4 0.444444444444444 0.00568990042674253
TF TF:M02066 Factor: PEA3; motif: RCCGGAAGYN 0.0163520331486525 7045 14 12 0.857142857142857 0.00170333569907736
TF TF:M09832 Factor: RFX1; motif: NGTTGCCATGG 0.0190716379141053 2370 4 4 1 0.00168776371308017
TF TF:M09816_1 Factor: NFYA; motif: RRCCAATCAGN; match class: 1 0.0197505685830464 278 9 3 0.333333333333333 0.0107913669064748
TF TF:M08213 Factor: Elk-1:TBR2; motif: TNRCACCGGAAGN 0.0200074794775167 6273 21 15 0.714285714285714 0.00239120038259206
TF TF:M02075 Factor: PDEF; motif: MCCGGATNTN 0.0207732734814746 2666 6 5 0.833333333333333 0.0018754688672168
TF TF:M01972 Factor: EGR-1; motif: TGCGTGGGCGK 0.0207732734814746 5360 17 12 0.705882352941177 0.00223880597014925
TF TF:M01862 Factor: ATF-2; motif: NNNTGACGTNAN 0.0209596172236809 3230 47 18 0.382978723404255 0.00557275541795666
TF TF:M06397 Factor: ZNF761; motif: NGGTYGGGCAWA 0.0209596172236809 33 73 3 0.0410958904109589 0.0909090909090909
TF TF:M08800 Factor: ARNT; motif: YRCGTGNN 0.0229520462179534 914 21 6 0.285714285714286 0.00656455142231947
TF TF:M11601_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.0229520462179534 11053 14 14 1 0.0012666244458518
TF TF:M09641 Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN 0.0229520462179534 3222 13 8 0.615384615384615 0.00248292985723153
TF TF:M12119_1 Factor: FPM315; motif: NGTGCTCCCN; match class: 1 0.0229520462179534 61 42 3 0.0714285714285714 0.0491803278688525
TF TF:M00634 Factor: GCM; motif: CNNRCCCGCATD 0.0235682454445187 2152 14 7 0.5 0.00325278810408922
TF TF:M09732 Factor: RFX3; motif: NYNCCMTGGCAACM 0.0245774553522275 5207 20 13 0.65 0.00249663913961974
TF TF:M04695 Factor: REST; motif: TTCAGCACCAYGGA 0.0274808785118633 1066 102 15 0.147058823529412 0.0140712945590994
TF TF:M11337_1 Factor: ATF-4; motif: GGATGACGTCATCC; match class: 1 0.0283536148117564 2806 128 33 0.2578125 0.0117605131860299
TF TF:M10638_1 Factor: Nkx2-3; motif: NNCGTTRWS; match class: 1 0.0283859315482666 4099 9 7 0.777777777777778 0.0017077335935594
TF TF:M11597 Factor: GCMb; motif: ATGCGGGTN 0.0283859315482666 1192 7 4 0.571428571428571 0.00335570469798658
TF TF:M00929 Factor: MyoD; motif: CNGNRNCAGGTGNNGNAN 0.0298966439239692 1488 3 3 1 0.00201612903225806
TF TF:M02067 Factor: ER71; motif: ACCGGAARYN 0.0303048463558241 5930 9 8 0.888888888888889 0.00134907251264755
TF TF:M11335 Factor: ATF-4; motif: GGATGACGTCATCC 0.0305945959621849 2292 125 28 0.224 0.012216404886562
TF TF:M02095 Factor: Fra-1; motif: TGAGTCAN 0.0305945959621849 1540 105 19 0.180952380952381 0.0123376623376623
TF TF:M00246 Factor: Egr-2; motif: NTGCGTRGGCGK 0.0305945959621849 6212 18 13 0.722222222222222 0.00209272376046362
TF TF:M11882_1 Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 0.0315242646523589 11423 14 14 1 0.0012255974787709
TF TF:M08583 Factor: GCMa:Max; motif: ATGCGGGTNNNNNNCACGTGN 0.0337687629037817 206 16 3 0.1875 0.0145631067961165
TF TF:M11733 Factor: PXR; motif: NYGAACTSNNTGAACTC 0.0337687629037817 2983 4 4 1 0.00134093194770365
TF TF:M04926 Factor: REST; motif: AAGGTGCT 0.0337687629037817 6325 102 49 0.480392156862745 0.00774703557312253
TF TF:M03834 Factor: N-Myc; motif: GSSCACGYGS 0.0337687629037817 1414 16 6 0.375 0.00424328147100424
TF TF:M10006_1 Factor: NF-YC; motif: NNRRCCAATCAGNR; match class: 1 0.0337687629037817 388 9 3 0.333333333333333 0.0077319587628866
TF TF:M00916 Factor: CREB; motif: NNTKACGTCANNNS 0.0337687629037817 5889 82 39 0.475609756097561 0.00662251655629139
TF TF:M02074 Factor: GABPalpha; motif: RCCGGAWRYN 0.0337687629037817 4607 13 9 0.692307692307692 0.00195354894725418
TF TF:M10468_1 Factor: ZBRK1; motif: NGNNNGGTNAWAAAARRGCNG; match class: 1 0.0337687629037817 4669 20 12 0.6 0.00257014349967873
TF TF:M10163 Factor: ZNF708; motif: GNNNAANAARNAGGYACAGC 0.0337687629037817 219 128 7 0.0546875 0.0319634703196347
TF TF:M03574 Factor: GCMa; motif: CCCGCAT 0.0337687629037817 2362 14 7 0.5 0.00296359017781541
TF TF:M05327 Factor: WT1; motif: NGCGGGGGGGTSMMCYN 0.0337687629037817 5509 34 19 0.558823529411765 0.00344890179705936
TF TF:M00185 Factor: NF-Y; motif: TRRCCAATSRN 0.036221243672461 870 10 4 0.4 0.00459770114942529
TF TF:M11671 Factor: IRF-5; motif: NCGAAACCGAAACY 0.0366716208415413 389 36 5 0.138888888888889 0.012853470437018
TF TF:M05386 Factor: KLF17; motif: NGGGCGG 0.0366716208415413 7900 8 8 1 0.0010126582278481
TF TF:M05499 Factor: LKLF; motif: NGGGCGG 0.0366716208415413 7900 8 8 1 0.0010126582278481
TF TF:M07041_1 Factor: HDAC1; motif: KGCARGGTC; match class: 1 0.0385100921076426 6354 128 59 0.4609375 0.00928548945546113
TF TF:M12140 Factor: Egr-1; motif: NNCRCCCMCGCNN 0.0387949803249775 5360 23 14 0.608695652173913 0.00261194029850746
TF TF:M01241_1 Factor: BEN; motif: CWGCGAYA; match class: 1 0.0395119839214418 2097 30 10 0.333333333333333 0.00476871721506915
TF TF:M11337 Factor: ATF-4; motif: GGATGACGTCATCC 0.0407144404823208 2911 128 33 0.2578125 0.0113363105462041
TF TF:M00649 Factor: MAZ; motif: GGGGAGGG 0.0445591301903535 9327 13 12 0.923076923076923 0.00128658732711483
TF TF:M04027 Factor: MEIS1; motif: NTGACAN 0.0445591301903535 3387 4 4 1 0.00118098612341305
TF TF:M01820 Factor: CREM; motif: TGACGTCASYN 0.0445591301903535 6303 89 43 0.48314606741573 0.00682214818340473
TF TF:M11222_1 Factor: CREB1; motif: NRTGAYGTCAYN; match class: 1 0.0445591301903535 1088 9 4 0.444444444444444 0.00367647058823529
TF TF:M02063 Factor: c-ets-1; motif: ACCGGAWGTN 0.0445591301903535 7600 13 11 0.846153846153846 0.00144736842105263
TF TF:M09826 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC 0.0445591301903535 11467 13 13 1 0.0011336879741868
TF TF:M07034 Factor: ATF-1; motif: NNNTGACGTNNN 0.0445591301903535 4248 98 35 0.357142857142857 0.00823917137476459
TF TF:M10024_1 Factor: p63; motif: NRCAWGYCCAGRCWTGYNN; match class: 1 0.0445591301903535 326 12 3 0.25 0.00920245398773006
TF TF:M00953 Factor: AR; motif: NNNGNRRGNACANNGTGTTCTNNNNNN 0.0445591301903535 2415 124 28 0.225806451612903 0.0115942028985507
TF TF:M07248 Factor: CREB1; motif: NNNNTGACGTNANNN 0.0456104830804263 4266 98 35 0.357142857142857 0.00820440693858415
TF TF:M02075_1 Factor: PDEF; motif: MCCGGATNTN; match class: 1 0.0465494403104028 267 33 4 0.121212121212121 0.0149812734082397
TF TF:M00801_1 Factor: CREB; motif: CGTCAN; match class: 1 0.0467649443850616 647 78 9 0.115384615384615 0.0139103554868624
TF TF:M11396_1 Factor: Erg; motif: NACCGGAARTN; match class: 1 0.0467649443850616 4963 5 5 1 0.00100745516824501
TF TF:M09905 Factor: SAP-1; motif: NNCCGGAAGTGN 0.0467649443850616 8273 14 12 0.857142857142857 0.00145050163181434
TF TF:M01814 Factor: AML2; motif: CCRCACCA 0.0475011402963217 2741 17 8 0.470588235294118 0.00291864283108355
TF TF:M08913 Factor: FLI-1; motif: NAYTTCCGGT 0.0487760180240824 8322 14 12 0.857142857142857 0.00144196106705119
TF TF:M08759 Factor: c-Ets-2; motif: NCCGGAAGTG 0.0487760180240824 8319 14 12 0.857142857142857 0.00144248106743599
TF TF:M00917 Factor: CREB; motif: CNNTGACGTMA 0.0491460344613457 5578 83 37 0.44578313253012 0.00663320186446755
TF TF:M11335_1 Factor: ATF-4; motif: GGATGACGTCATCC; match class: 1 0.0498290536337362 2207 124 26 0.209677419354839 0.0117806977797916
TF TF:M09808_1 Factor: KLF4; motif: MCACACCCTNN; match class: 1 0.0498290536337362 530 30 5 0.166666666666667 0.00943396226415094
TF TF:M03558_1 Factor: P73; motif: GNNNRRRCNTGCMNNTSASN; match class: 1 0.0498290536337362 822 12 4 0.333333333333333 0.0048661800486618
WP WP:WP2884 NRF2 pathway 0.000390845922221346 145 6 4 0.666666666666667 0.0275862068965517
WP WP:WP2359 Parkin-Ubiquitin Proteasomal System pathway 0.000650391255823535 70 14 4 0.285714285714286 0.0571428571428571
WP WP:WP2882 Nuclear Receptors Meta-Pathway 0.0029552594016775 321 24 7 0.291666666666667 0.0218068535825545
WP WP:WP382 MAPK Signaling Pathway 0.00301229708161965 249 14 5 0.357142857142857 0.0200803212851406
WP WP:WP2864 Apoptosis-related network due to altered Notch3 in ovarian cancer 0.00533307364557499 54 37 4 0.108108108108108 0.0740740740740741
WP WP:WP3888 VEGFA-VEGFR2 Signaling Pathway 0.0150795992628564 437 19 6 0.315789473684211 0.0137299771167048
WP WP:WP408 Oxidative Stress 0.0388655560228616 34 112 4 0.0357142857142857 0.117647058823529

pP07 transcription factor target enrichment of top program genes

TF enrichment of pP07
TFs corrosponding to activation of pP07. (Left) pearson correlation of TF expression and gene expression program activatity in Plasma cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.