pEpiTd18 program activity among Epithelial cells

Activation of pEpiTd18
pEpiTd18 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTd18 by different cell subtypes
pEpiTd18 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTd18 top program genes

Top genes of pEpiTd18 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTd18 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTd18
pEpiTd18 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002443 leukocyte mediated immunity 1.79906327586325e-11 877 90 27 0.3 0.0307867730900798
GO:BP GO:0006959 humoral immune response 3.98684220389296e-11 384 102 20 0.196078431372549 0.0520833333333333
GO:BP GO:0002283 neutrophil activation involved in immune response 3.03926344606594e-10 485 20 11 0.55 0.022680412371134
GO:BP GO:0043312 neutrophil degranulation 3.03926344606594e-10 482 20 11 0.55 0.0228215767634855
GO:BP GO:0042119 neutrophil activation 3.03926344606594e-10 498 20 11 0.55 0.0220883534136546
GO:BP GO:0036230 granulocyte activation 3.03926344606594e-10 504 20 11 0.55 0.0218253968253968
GO:BP GO:0002446 neutrophil mediated immunity 3.03926344606594e-10 497 20 11 0.55 0.0221327967806841
GO:BP GO:0043299 leukocyte degranulation 5.08660067541852e-10 535 20 11 0.55 0.0205607476635514
GO:BP GO:0002275 myeloid cell activation involved in immune response 5.60218950540467e-10 547 20 11 0.55 0.020109689213894
GO:BP GO:0002444 myeloid leukocyte mediated immunity 5.60218950540467e-10 551 20 11 0.55 0.0199637023593466
GO:BP GO:0002252 immune effector process 5.65707270560784e-10 1309 102 31 0.303921568627451 0.0236822001527884
GO:BP GO:0006958 complement activation, classical pathway 1.05030583087075e-09 142 115 13 0.11304347826087 0.0915492957746479
GO:BP GO:0045055 regulated exocytosis 1.05030583087075e-09 785 25 13 0.52 0.0165605095541401
GO:BP GO:0006955 immune response 1.58063822808322e-09 2311 97 39 0.402061855670103 0.0168758113370835
GO:BP GO:0042742 defense response to bacterium 1.58063822808322e-09 349 102 17 0.166666666666667 0.0487106017191977
GO:BP GO:0002274 myeloid leukocyte activation 2.66918153921548e-09 667 20 11 0.55 0.0164917541229385
GO:BP GO:0002455 humoral immune response mediated by circulating immunoglobulin 2.66918153921548e-09 156 115 13 0.11304347826087 0.0833333333333333
GO:BP GO:0006887 exocytosis 4.0841393322665e-09 904 25 13 0.52 0.0143805309734513
GO:BP GO:0002376 immune system process 4.0841393322665e-09 3278 97 46 0.474226804123711 0.014032946918853
GO:BP GO:0002366 leukocyte activation involved in immune response 4.80463317793642e-09 717 20 11 0.55 0.0153417015341702
GO:BP GO:0002263 cell activation involved in immune response 4.85752936203811e-09 721 20 11 0.55 0.0152565880721221
GO:BP GO:0009617 response to bacterium 1.20307227273628e-08 743 102 22 0.215686274509804 0.0296096904441454
GO:BP GO:0006956 complement activation 1.20307227273628e-08 180 115 13 0.11304347826087 0.0722222222222222
GO:BP GO:0016064 immunoglobulin mediated immune response 1.381394722544e-08 223 115 14 0.121739130434783 0.062780269058296
GO:BP GO:0019724 B cell mediated immunity 1.58288725602863e-08 226 115 14 0.121739130434783 0.0619469026548673
GO:BP GO:0140352 export from cell 3.87841466811882e-08 1418 21 13 0.619047619047619 0.00916784203102962
GO:BP GO:0046903 secretion 7.56523127731258e-08 1501 21 13 0.619047619047619 0.00866089273817455
GO:BP GO:0016192 vesicle-mediated transport 1.18505767373986e-07 2180 90 33 0.366666666666667 0.0151376146788991
GO:BP GO:0032940 secretion by cell 3.87627908069964e-07 1364 21 12 0.571428571428571 0.00879765395894428
GO:BP GO:0002449 lymphocyte mediated immunity 5.36833495668253e-07 354 115 15 0.130434782608696 0.0423728813559322
GO:BP GO:0001775 cell activation 6.24986027450171e-07 1495 102 28 0.274509803921569 0.0187290969899666
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 7.04927264370118e-07 363 115 15 0.130434782608696 0.0413223140495868
GO:BP GO:0002250 adaptive immune response 8.27508681930364e-07 689 115 20 0.173913043478261 0.0290275761973875
GO:BP GO:0045321 leukocyte activation 1.33684532588647e-06 1332 90 24 0.266666666666667 0.018018018018018
GO:BP GO:0006909 phagocytosis 1.51216633604305e-06 387 115 15 0.130434782608696 0.0387596899224806
GO:BP GO:0006911 phagocytosis, engulfment 2.58558796488484e-06 127 102 9 0.0882352941176471 0.0708661417322835
GO:BP GO:0099024 plasma membrane invagination 4.55703810932307e-06 136 102 9 0.0882352941176471 0.0661764705882353
GO:BP GO:0006910 phagocytosis, recognition 4.77529114909569e-06 98 102 8 0.0784313725490196 0.0816326530612245
GO:BP GO:0010324 membrane invagination 7.07606825994357e-06 144 102 9 0.0882352941176471 0.0625
GO:BP GO:0050871 positive regulation of B cell activation 1.03627941709563e-05 151 102 9 0.0882352941176471 0.0596026490066225
GO:BP GO:0019730 antimicrobial humoral response 4.72586114563821e-05 145 41 6 0.146341463414634 0.0413793103448276
GO:BP GO:0050853 B cell receptor signaling pathway 5.12574112948798e-05 135 102 8 0.0784313725490196 0.0592592592592593
GO:BP GO:0050864 regulation of B cell activation 7.95647069664218e-05 194 102 9 0.0882352941176471 0.0463917525773196
GO:BP GO:0006897 endocytosis 8.259747465817e-05 696 90 15 0.166666666666667 0.021551724137931
GO:BP GO:0002684 positive regulation of immune system process 8.37388719428266e-05 1065 102 20 0.196078431372549 0.0187793427230047
GO:BP GO:0008037 cell recognition 8.37388719428266e-05 235 110 10 0.0909090909090909 0.0425531914893617
GO:BP GO:0051649 establishment of localization in cell 8.5790322548625e-05 2813 21 13 0.619047619047619 0.00462140063988624
GO:BP GO:0002682 regulation of immune system process 0.000114192674617858 1617 102 25 0.245098039215686 0.015460729746444
GO:BP GO:0050776 regulation of immune response 0.000118705674110765 996 102 19 0.186274509803922 0.0190763052208835
GO:BP GO:0045730 respiratory burst 0.000135529107810086 35 15 3 0.2 0.0857142857142857
GO:BP GO:0043207 response to external biotic stimulus 0.000145187475687009 1594 25 11 0.44 0.006900878293601
GO:BP GO:0051707 response to other organism 0.000145187475687009 1592 25 11 0.44 0.00690954773869347
GO:BP GO:0098542 defense response to other organism 0.000148517952405358 1218 102 21 0.205882352941176 0.0172413793103448
GO:BP GO:0009607 response to biotic stimulus 0.00016949814234682 1626 25 11 0.44 0.00676506765067651
GO:BP GO:0034599 cellular response to oxidative stress 0.00016949814234682 316 15 5 0.333333333333333 0.0158227848101266
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.00018525978727166 512 115 14 0.121739130434783 0.02734375
GO:BP GO:0002764 immune response-regulating signaling pathway 0.000194621362434398 515 115 14 0.121739130434783 0.0271844660194175
GO:BP GO:0006954 inflammatory response 0.000288709837582441 794 25 8 0.32 0.0100755667506297
GO:BP GO:0062197 cellular response to chemical stress 0.00031358934244179 365 15 5 0.333333333333333 0.0136986301369863
GO:BP GO:0045087 innate immune response 0.000383038065549031 998 102 18 0.176470588235294 0.0180360721442886
GO:BP GO:0002757 immune response-activating signal transduction 0.000383038065549031 477 115 13 0.11304347826087 0.0272536687631027
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.000383038065549031 477 115 13 0.11304347826087 0.0272536687631027
GO:BP GO:0006952 defense response 0.000423714812054474 1818 25 11 0.44 0.00605060506050605
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.000513346291717548 2255 25 12 0.48 0.00532150776053215
GO:BP GO:0001895 retina homeostasis 0.000592404926020891 79 12 3 0.25 0.0379746835443038
GO:BP GO:0050778 positive regulation of immune response 0.00068301124633026 753 102 15 0.147058823529412 0.0199203187250996
GO:BP GO:0006801 superoxide metabolic process 0.000717884551217409 67 15 3 0.2 0.0447761194029851
GO:BP GO:0002920 regulation of humoral immune response 0.000738458542118231 133 115 7 0.0608695652173913 0.0526315789473684
GO:BP GO:0051641 cellular localization 0.000810603010257357 3541 21 13 0.619047619047619 0.00367127929963287
GO:BP GO:0006979 response to oxidative stress 0.000862676886000441 466 15 5 0.333333333333333 0.0107296137339056
GO:BP GO:0002253 activation of immune response 0.00200505812390883 568 115 13 0.11304347826087 0.022887323943662
GO:BP GO:0006810 transport 0.00200505812390883 5224 21 15 0.714285714285714 0.00287136294027565
GO:BP GO:0030449 regulation of complement activation 0.00219473325391322 110 115 6 0.0521739130434783 0.0545454545454545
GO:BP GO:0050900 leukocyte migration 0.00265820790082755 511 97 11 0.11340206185567 0.0215264187866928
GO:BP GO:0033993 response to lipid 0.00265820790082755 918 6 4 0.666666666666667 0.00435729847494553
GO:BP GO:0051234 establishment of localization 0.00268389333660043 5372 21 15 0.714285714285714 0.00279225614296351
GO:BP GO:0048871 multicellular organismal homeostasis 0.00278992378982794 530 4 3 0.75 0.00566037735849057
GO:BP GO:0001894 tissue homeostasis 0.00281856230491876 270 97 8 0.0824742268041237 0.0296296296296296
GO:BP GO:0042113 B cell activation 0.00283172894571374 330 102 9 0.0882352941176471 0.0272727272727273
GO:BP GO:0002696 positive regulation of leukocyte activation 0.00294083290651968 412 102 10 0.0980392156862745 0.0242718446601942
GO:BP GO:0008217 regulation of blood pressure 0.00310317463706631 193 72 6 0.0833333333333333 0.0310880829015544
GO:BP GO:0032496 response to lipopolysaccharide 0.00321432379963144 338 6 3 0.5 0.00887573964497041
GO:BP GO:0050867 positive regulation of cell activation 0.00356850423643215 424 102 10 0.0980392156862745 0.0235849056603774
GO:BP GO:0042592 homeostatic process 0.00358925361132314 1981 4 4 1 0.00201918223119637
GO:BP GO:0002237 response to molecule of bacterial origin 0.00371579188385716 361 6 3 0.5 0.00831024930747922
GO:BP GO:0002694 regulation of leukocyte activation 0.00395674594426763 610 102 12 0.117647058823529 0.019672131147541
GO:BP GO:0002697 regulation of immune effector process 0.00404641841352756 461 115 11 0.0956521739130435 0.0238611713665944
GO:BP GO:0009605 response to external stimulus 0.00416778888129928 2944 28 13 0.464285714285714 0.00441576086956522
GO:BP GO:0042493 response to drug 0.00456740455217732 396 6 3 0.5 0.00757575757575758
GO:BP GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 0.00488261398520363 135 115 6 0.0521739130434783 0.0444444444444444
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.00488261398520363 365 102 9 0.0882352941176471 0.0246575342465753
GO:BP GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 0.00488261398520363 135 115 6 0.0521739130434783 0.0444444444444444
GO:BP GO:0038094 Fc-gamma receptor signaling pathway 0.0051876681447909 137 115 6 0.0521739130434783 0.0437956204379562
GO:BP GO:0006027 glycosaminoglycan catabolic process 0.0051876681447909 61 36 3 0.0833333333333333 0.0491803278688525
GO:BP GO:0002431 Fc receptor mediated stimulatory signaling pathway 0.00594741547531886 141 115 6 0.0521739130434783 0.0425531914893617
GO:BP GO:0006026 aminoglycan catabolic process 0.00635385325601203 67 36 3 0.0833333333333333 0.0447761194029851
GO:BP GO:0008015 blood circulation 0.00635385325601203 553 72 9 0.125 0.0162748643761302
GO:BP GO:0050865 regulation of cell activation 0.00635385325601203 655 102 12 0.117647058823529 0.0183206106870229
GO:BP GO:0003073 regulation of systemic arterial blood pressure 0.00664368577084427 101 25 3 0.12 0.0297029702970297
GO:BP GO:0006950 response to stress 0.00699015393927162 4170 15 10 0.666666666666667 0.00239808153477218
GO:BP GO:0048584 positive regulation of response to stimulus 0.00744913226415733 2344 91 24 0.263736263736264 0.0102389078498294
GO:BP GO:0051179 localization 0.0075590458126689 6901 21 16 0.761904761904762 0.00231850456455586
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.00814958818730701 323 102 8 0.0784313725490196 0.0247678018575851
GO:BP GO:0031640 killing of cells of other organism 0.00837473122427542 69 41 3 0.0731707317073171 0.0434782608695652
GO:BP GO:0009636 response to toxic substance 0.00995648422305155 243 13 3 0.230769230769231 0.0123456790123457
GO:BP GO:0001906 cell killing 0.0103257151276232 175 41 4 0.0975609756097561 0.0228571428571429
GO:BP GO:0042221 response to chemical 0.0103767458051224 4781 21 13 0.619047619047619 0.0027190964233424
GO:BP GO:0051249 regulation of lymphocyte activation 0.0107064268637889 518 102 10 0.0980392156862745 0.0193050193050193
GO:BP GO:0038095 Fc-epsilon receptor signaling pathway 0.0107396418300316 167 115 6 0.0521739130434783 0.0359281437125748
GO:BP GO:0044706 multi-multicellular organism process 0.0107531066044536 227 85 6 0.0705882352941176 0.026431718061674
GO:BP GO:0038093 Fc receptor signaling pathway 0.0118058268946362 238 115 7 0.0608695652173913 0.0294117647058824
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.0126170648753126 1455 21 7 0.333333333333333 0.00481099656357388
GO:BP GO:0003013 circulatory system process 0.0127095379925224 637 72 9 0.125 0.0141287284144427
GO:BP GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 0.0128567142573643 81 97 4 0.0412371134020619 0.0493827160493827
GO:BP GO:0080171 lytic vacuole organization 0.0138225963201082 72 50 3 0.06 0.0416666666666667
GO:BP GO:0007040 lysosome organization 0.0138225963201082 72 50 3 0.06 0.0416666666666667
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.0139311838777149 1227 25 7 0.28 0.00570497147514262
GO:BP GO:1901700 response to oxygen-containing compound 0.0140142745752838 1739 6 4 0.666666666666667 0.00230017251293847
GO:BP GO:0048870 cell motility 0.0140142745752838 1828 75 17 0.226666666666667 0.00929978118161926
GO:BP GO:0060249 anatomical structure homeostasis 0.0140142745752838 482 78 8 0.102564102564103 0.016597510373444
GO:BP GO:0051674 localization of cell 0.0140142745752838 1828 75 17 0.226666666666667 0.00929978118161926
GO:BP GO:0031349 positive regulation of defense response 0.0147473675256599 362 11 3 0.272727272727273 0.00828729281767956
GO:BP GO:0002224 toll-like receptor signaling pathway 0.0152167241955725 161 24 3 0.125 0.0186335403726708
GO:BP GO:0006898 receptor-mediated endocytosis 0.0157297787140063 333 89 7 0.0786516853932584 0.021021021021021
GO:BP GO:0050829 defense response to Gram-negative bacterium 0.0158095064966617 88 97 4 0.0412371134020619 0.0454545454545455
GO:BP GO:0050679 positive regulation of epithelial cell proliferation 0.0186774005288028 213 20 3 0.15 0.0140845070422535
GO:BP GO:0072593 reactive oxygen species metabolic process 0.0188133947598251 290 15 3 0.2 0.0103448275862069
GO:BP GO:0055114 obsolete oxidation-reduction process 0.0199045951093636 745 43 7 0.162790697674419 0.00939597315436242
GO:BP GO:0030316 osteoclast differentiation 0.0215352218977465 98 97 4 0.0412371134020619 0.0408163265306122
GO:BP GO:0001523 retinoid metabolic process 0.0223392264810997 107 43 3 0.0697674418604651 0.0280373831775701
GO:BP GO:0050830 defense response to Gram-positive bacterium 0.022487603666975 101 97 4 0.0412371134020619 0.0396039603960396
GO:BP GO:0048583 regulation of response to stimulus 0.0235010020306412 4278 91 34 0.373626373626374 0.00794763908368396
GO:BP GO:0006928 movement of cell or subcellular component 0.0236125751852259 2311 75 19 0.253333333333333 0.00822154911293812
GO:BP GO:0007565 female pregnancy 0.0244731374912276 198 85 5 0.0588235294117647 0.0252525252525253
GO:BP GO:0016101 diterpenoid metabolic process 0.0246152169382366 113 43 3 0.0697674418604651 0.0265486725663717
GO:BP GO:0019731 antibacterial humoral response 0.0253450269532297 62 80 3 0.0375 0.0483870967741935
GO:BP GO:0065008 regulation of biological quality 0.0260173104686977 4131 4 4 1 0.000968288549987896
GO:BP GO:0002221 pattern recognition receptor signaling pathway 0.0260173104686977 213 24 3 0.125 0.0140845070422535
GO:BP GO:0016477 cell migration 0.0260799277845218 1649 75 15 0.2 0.00909642207398423
GO:BP GO:0006721 terpenoid metabolic process 0.0279955377699723 123 43 3 0.0697674418604651 0.024390243902439
GO:BP GO:0061024 membrane organization 0.0279955377699723 973 90 12 0.133333333333333 0.0123329907502569
GO:BP GO:0045453 bone resorption 0.0282713945739331 68 78 3 0.0384615384615385 0.0441176470588235
GO:BP GO:0032103 positive regulation of response to external stimulus 0.0282713945739331 513 11 3 0.272727272727273 0.00584795321637427
GO:BP GO:0040011 locomotion 0.0290125341404934 2028 75 17 0.226666666666667 0.00838264299802761
GO:BP GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0312548195512969 110 51 3 0.0588235294117647 0.0272727272727273
GO:BP GO:0030203 glycosaminoglycan metabolic process 0.031811512394368 159 36 3 0.0833333333333333 0.0188679245283019
GO:BP GO:0006665 sphingolipid metabolic process 0.031811512394368 169 34 3 0.0882352941176471 0.0177514792899408
GO:BP GO:0002763 positive regulation of myeloid leukocyte differentiation 0.0319173990381219 59 97 3 0.0309278350515464 0.0508474576271186
GO:BP GO:1901136 carbohydrate derivative catabolic process 0.0322417976307713 196 60 4 0.0666666666666667 0.0204081632653061
GO:BP GO:0046649 lymphocyte activation 0.0323315503285051 771 102 11 0.107843137254902 0.0142671854734112
GO:BP GO:0070482 response to oxygen levels 0.0329740304270907 408 15 3 0.2 0.00735294117647059
GO:BP GO:0002761 regulation of myeloid leukocyte differentiation 0.0336007736528309 123 97 4 0.0412371134020619 0.032520325203252
GO:BP GO:0009311 oligosaccharide metabolic process 0.0346497859022523 53 114 3 0.0263157894736842 0.0566037735849057
GO:BP GO:0070839 metal ion export 0.0348286431935356 51 119 3 0.0252100840336134 0.0588235294117647
GO:BP GO:0033554 cellular response to stress 0.0355920581368605 2111 15 6 0.4 0.00284225485551871
GO:BP GO:0006720 isoprenoid metabolic process 0.0355920581368605 144 43 3 0.0697674418604651 0.0208333333333333
GO:BP GO:0006022 aminoglycan metabolic process 0.0355920581368605 173 36 3 0.0833333333333333 0.0173410404624277
GO:BP GO:0001525 angiogenesis 0.0358537812862233 617 21 4 0.19047619047619 0.00648298217179903
GO:BP GO:0050678 regulation of epithelial cell proliferation 0.0369410435271515 401 32 4 0.125 0.00997506234413965
GO:BP GO:0045670 regulation of osteoclast differentiation 0.0373969940643299 66 97 3 0.0309278350515464 0.0454545454545455
GO:BP GO:0006915 apoptotic process 0.0380784307908701 1990 21 7 0.333333333333333 0.00351758793969849
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0382386921574265 3210 3 3 1 0.000934579439252336
GO:BP GO:0002573 myeloid leukocyte differentiation 0.039308943839312 213 97 5 0.0515463917525773 0.0234741784037559
GO:BP GO:0002576 platelet degranulation 0.041121631673971 126 105 4 0.0380952380952381 0.0317460317460317
GO:BP GO:0097529 myeloid leukocyte migration 0.0418352599997965 221 97 5 0.0515463917525773 0.0226244343891403
GO:BP GO:0006900 vesicle budding from membrane 0.0418352599997965 107 65 3 0.0461538461538462 0.0280373831775701
GO:BP GO:0006508 proteolysis 0.0418352599997965 1836 41 10 0.24390243902439 0.00544662309368192
GO:BP GO:0060048 cardiac muscle contraction 0.0418352599997965 139 50 3 0.06 0.0215827338129496
GO:BP GO:0042981 regulation of apoptotic process 0.0418352599997965 1549 21 6 0.285714285714286 0.00387346675274371
GO:BP GO:0072359 circulatory system development 0.0428991936500616 1194 72 11 0.152777777777778 0.00921273031825796
GO:BP GO:0005977 glycogen metabolic process 0.0440332737412151 79 92 3 0.0326086956521739 0.0379746835443038
GO:BP GO:0031347 regulation of defense response 0.0440332737412151 704 11 3 0.272727272727273 0.00426136363636364
GO:BP GO:0043067 regulation of programmed cell death 0.0440332737412151 1582 21 6 0.285714285714286 0.00379266750948167
GO:BP GO:0046849 bone remodeling 0.0440332737412151 93 78 3 0.0384615384615385 0.032258064516129
GO:BP GO:0006643 membrane lipid metabolic process 0.0443002012869176 217 34 3 0.0882352941176471 0.0138248847926267
GO:BP GO:0045638 negative regulation of myeloid cell differentiation 0.0444137496516536 94 78 3 0.0384615384615385 0.0319148936170213
GO:BP GO:0044042 glucan metabolic process 0.0444137496516536 80 92 3 0.0326086956521739 0.0375
GO:BP GO:0006073 cellular glucan metabolic process 0.0444137496516536 80 92 3 0.0326086956521739 0.0375
GO:BP GO:0140115 export across plasma membrane 0.0444137496516536 62 119 3 0.0252100840336134 0.0483870967741935
GO:BP GO:0045765 regulation of angiogenesis 0.0444137496516536 358 21 3 0.142857142857143 0.00837988826815642
GO:BP GO:0030001 metal ion transport 0.0444137496516536 514 44 5 0.113636363636364 0.00972762645914397
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.0451341717812198 363 21 3 0.142857142857143 0.00826446280991736
GO:BP GO:0012501 programmed cell death 0.0451366066484667 2143 21 7 0.333333333333333 0.00326644890340644
GO:BP GO:0048514 blood vessel morphogenesis 0.0451366066484667 711 21 4 0.19047619047619 0.00562587904360056
GO:BP GO:1901342 regulation of vasculature development 0.0451366066484667 364 21 3 0.142857142857143 0.00824175824175824
GO:BP GO:0050673 epithelial cell proliferation 0.0454016792723147 460 32 4 0.125 0.00869565217391304
GO:BP GO:0006790 sulfur compound metabolic process 0.0455854099058378 386 38 4 0.105263157894737 0.0103626943005181
GO:BP GO:0097530 granulocyte migration 0.0469825136396333 151 97 4 0.0412371134020619 0.0264900662251656
GO:BP GO:0030162 regulation of proteolysis 0.0479879665152322 752 11 3 0.272727272727273 0.00398936170212766
GO:BP GO:0060326 cell chemotaxis 0.048337787640273 310 75 5 0.0666666666666667 0.0161290322580645
GO:BP GO:0070887 cellular response to chemical stimulus 0.0487076959328166 3393 21 9 0.428571428571429 0.0026525198938992
GO:CC GO:0005615 extracellular space 3.60299068990481e-18 3594 102 62 0.607843137254902 0.0172509738452977
GO:CC GO:0005576 extracellular region 5.97375264096223e-17 4567 97 65 0.670103092783505 0.0142325377709656
GO:CC GO:0019814 immunoglobulin complex 9.17800347058236e-16 167 115 18 0.156521739130435 0.107784431137725
GO:CC GO:0043230 extracellular organelle 1.13926524497451e-12 2263 79 37 0.468354430379747 0.0163499779054353
GO:CC GO:0070062 extracellular exosome 1.77032599516736e-12 2176 79 36 0.455696202531646 0.0165441176470588
GO:CC GO:0031982 vesicle 3.5723729301267e-12 4055 25 23 0.92 0.00567200986436498
GO:CC GO:1903561 extracellular vesicle 4.11363662368946e-12 2261 79 36 0.455696202531646 0.015922158337019
GO:CC GO:0030141 secretory granule 1.28725972327198e-11 851 25 14 0.56 0.0164512338425382
GO:CC GO:0099503 secretory vesicle 1.33687974421401e-10 1020 25 14 0.56 0.0137254901960784
GO:CC GO:0005766 primary lysosome 2.5920862991258e-09 154 19 7 0.368421052631579 0.0454545454545455
GO:CC GO:0042582 azurophil granule 2.5920862991258e-09 154 19 7 0.368421052631579 0.0454545454545455
GO:CC GO:0034774 secretory granule lumen 2.69266134580605e-09 320 33 10 0.303030303030303 0.03125
GO:CC GO:0031983 vesicle lumen 2.76786984103727e-09 326 33 10 0.303030303030303 0.0306748466257669
GO:CC GO:0060205 cytoplasmic vesicle lumen 2.76786984103727e-09 324 33 10 0.303030303030303 0.0308641975308642
GO:CC GO:0042571 immunoglobulin complex, circulating 6.32173056656636e-09 77 102 9 0.0882352941176471 0.116883116883117
GO:CC GO:0005775 vacuolar lumen 1.28426523513917e-08 174 50 9 0.18 0.0517241379310345
GO:CC GO:0097708 intracellular vesicle 1.67136618578665e-08 2428 21 15 0.714285714285714 0.00617792421746293
GO:CC GO:0031410 cytoplasmic vesicle 1.67136618578665e-08 2424 21 15 0.714285714285714 0.00618811881188119
GO:CC GO:0062023 collagen-containing extracellular matrix 7.66452344751349e-08 421 47 11 0.234042553191489 0.0261282660332542
GO:CC GO:0031012 extracellular matrix 1.21745458164927e-07 562 47 12 0.25531914893617 0.0213523131672598
GO:CC GO:0030312 external encapsulating structure 1.21745458164927e-07 563 47 12 0.25531914893617 0.0213143872113677
GO:CC GO:0000323 lytic vacuole 1.22218713958367e-07 712 19 9 0.473684210526316 0.0126404494382022
GO:CC GO:0005764 lysosome 1.22218713958367e-07 712 19 9 0.473684210526316 0.0126404494382022
GO:CC GO:0042581 specific granule 2.90222478842537e-07 158 5 4 0.8 0.0253164556962025
GO:CC GO:0005773 vacuole 3.44156981462522e-07 810 19 9 0.473684210526316 0.0111111111111111
GO:CC GO:0035580 specific granule lumen 7.5007709796888e-07 61 33 5 0.151515151515152 0.0819672131147541
GO:CC GO:0043202 lysosomal lumen 2.27266232222445e-06 97 50 6 0.12 0.0618556701030928
GO:CC GO:0035578 azurophil granule lumen 5.167213904551e-06 91 14 4 0.285714285714286 0.043956043956044
GO:CC GO:0012505 endomembrane system 6.65968168082444e-06 4640 27 19 0.703703703703704 0.0040948275862069
GO:CC GO:0009897 external side of plasma membrane 1.99178344492346e-05 408 102 12 0.117647058823529 0.0294117647058824
GO:CC GO:0071944 cell periphery 0.000137487997950416 6169 97 52 0.536082474226804 0.00842924298913924
GO:CC GO:0070820 tertiary granule 0.000626484902885529 163 50 5 0.1 0.0306748466257669
GO:CC GO:0030667 secretory granule membrane 0.000692760812597575 303 6 3 0.5 0.0099009900990099
GO:CC GO:1904724 tertiary granule lumen 0.00102236283560006 55 33 3 0.0909090909090909 0.0545454545454545
GO:CC GO:0098552 side of membrane 0.0010245111127019 619 102 12 0.117647058823529 0.0193861066235864
GO:CC GO:0031225 anchored component of membrane 0.00160213605404405 174 32 4 0.125 0.0229885057471264
GO:CC GO:0009986 cell surface 0.00248137033337361 899 102 14 0.137254901960784 0.0155728587319244
GO:CC GO:0005788 endoplasmic reticulum lumen 0.00373496349295354 307 113 8 0.0707964601769911 0.0260586319218241
GO:CC GO:0045177 apical part of cell 0.00373496349295354 431 17 4 0.235294117647059 0.00928074245939675
GO:CC GO:0005765 lysosomal membrane 0.00430724169056586 383 9 3 0.333333333333333 0.00783289817232376
GO:CC GO:0098852 lytic vacuole membrane 0.00430724169056586 383 9 3 0.333333333333333 0.00783289817232376
GO:CC GO:0005774 vacuolar membrane 0.00582881506308489 441 9 3 0.333333333333333 0.00680272108843537
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.00760357017822151 779 6 3 0.5 0.00385109114249037
GO:CC GO:1904813 ficolin-1-rich granule lumen 0.00764341244705109 124 33 3 0.0909090909090909 0.0241935483870968
GO:CC GO:0101002 ficolin-1-rich granule 0.00781651148462344 184 50 4 0.08 0.0217391304347826
GO:CC GO:0043227 membrane-bounded organelle 0.00781651148462344 12858 39 35 0.897435897435897 0.0027220407528387
GO:CC GO:0012506 vesicle membrane 0.00781651148462344 800 6 3 0.5 0.00375
GO:CC GO:0005768 endosome 0.0100819992135001 987 18 5 0.277777777777778 0.00506585612968592
GO:CC GO:0005794 Golgi apparatus 0.0159114727967117 1623 13 5 0.384615384615385 0.00308071472581639
GO:CC GO:0005886 plasma membrane 0.0160861232885248 5681 108 46 0.425925925925926 0.00809716599190283
GO:CC GO:0016324 apical plasma membrane 0.0172065549682495 361 17 3 0.176470588235294 0.00831024930747922
GO:CC GO:0098588 bounding membrane of organelle 0.0206832261801764 2158 11 5 0.454545454545455 0.00231696014828545
GO:CC GO:0005783 endoplasmic reticulum 0.0234209222916244 1982 39 10 0.256410256410256 0.00504540867810293
GO:CC GO:0031226 intrinsic component of plasma membrane 0.0417467439630306 1726 22 6 0.272727272727273 0.00347624565469293
GO:CC GO:0043226 organelle 0.0417467439630306 14008 34 31 0.911764705882353 0.00221302113078241
GO:CC GO:0031091 platelet alpha granule 0.0464481515089323 90 105 3 0.0285714285714286 0.0333333333333333
GO:CC GO:0008076 voltage-gated potassium channel complex 0.0477878291017713 90 107 3 0.0280373831775701 0.0333333333333333
GO:CC GO:0031984 organelle subcompartment 0.0482515547138471 1773 11 4 0.363636363636364 0.00225606316976875
GO:MF GO:0003823 antigen binding 9.91353654326582e-09 163 115 13 0.11304347826087 0.0797546012269939
GO:MF GO:0034987 immunoglobulin receptor binding 2.36139468326229e-06 79 102 8 0.0784313725490196 0.10126582278481
GO:MF GO:0016798 hydrolase activity, acting on glycosyl bonds 0.00357697902629541 139 50 5 0.1 0.0359712230215827
GO:MF GO:0005518 collagen binding 0.0051553172336763 70 116 5 0.0431034482758621 0.0714285714285714
GO:MF GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 0.00737839075635864 99 50 4 0.08 0.0404040404040404
GO:MF GO:1901681 sulfur compound binding 0.0178196615977728 264 28 4 0.142857142857143 0.0151515151515152
GO:MF GO:0008201 heparin binding 0.0307013510230705 168 28 3 0.107142857142857 0.0178571428571429
GO:MF GO:0005125 cytokine activity 0.0307013510230705 235 97 6 0.0618556701030928 0.025531914893617
GO:MF GO:0005102 signaling receptor binding 0.0307013510230705 1672 102 19 0.186274509803922 0.0113636363636364
GO:MF GO:0061134 peptidase regulator activity 0.0307013510230705 224 110 6 0.0545454545454545 0.0267857142857143
GO:MF GO:0016491 oxidoreductase activity 0.0307013510230705 771 43 7 0.162790697674419 0.00907911802853437
GO:MF GO:0003824 catalytic activity 0.0364689010279436 5896 40 21 0.525 0.00356173677069199
GO:MF GO:0004252 serine-type endopeptidase activity 0.0364689010279436 171 35 3 0.0857142857142857 0.0175438596491228
GO:MF GO:0005201 extracellular matrix structural constituent 0.0364689010279436 171 116 5 0.0431034482758621 0.0292397660818713
GO:MF GO:0008236 serine-type peptidase activity 0.0364689010279436 189 107 5 0.0467289719626168 0.0264550264550265
GO:MF GO:0030414 peptidase inhibitor activity 0.0364689010279436 182 110 5 0.0454545454545455 0.0274725274725275
GO:MF GO:0046914 transition metal ion binding 0.0364689010279436 1111 43 8 0.186046511627907 0.0072007200720072
GO:MF GO:0042802 identical protein binding 0.0364689010279436 2067 11 5 0.454545454545455 0.00241896468311563
GO:MF GO:0005539 glycosaminoglycan binding 0.0370701316327028 238 28 3 0.107142857142857 0.0126050420168067
GO:MF GO:0017171 serine hydrolase activity 0.0370701316327028 193 107 5 0.0467289719626168 0.0259067357512953
GO:MF GO:0046982 protein heterodimerization activity 0.0370701316327028 357 19 3 0.157894736842105 0.00840336134453781
GO:MF GO:0016787 hydrolase activity 0.0411247853475779 2615 40 12 0.3 0.00458891013384321
GO:MF GO:0008233 peptidase activity 0.0486416011521691 646 85 8 0.0941176470588235 0.0123839009287926
REAC REAC:R-HSA-6798695 Neutrophil degranulation 5.21018383617816e-08 474 20 11 0.55 0.0232067510548523
REAC REAC:R-HSA-168249 Innate Immune System 0.000134855682077519 1073 20 11 0.55 0.0102516309412861
REAC REAC:R-HSA-166786 Creation of C4 and C2 activators 0.00372168535706332 68 115 6 0.0521739130434783 0.0882352941176471
REAC REAC:R-HSA-2168880 Scavenging of heme from plasma 0.00372168535706332 67 115 6 0.0521739130434783 0.0895522388059701
REAC REAC:R-HSA-5690714 CD22 mediated BCR regulation 0.00372168535706332 61 115 6 0.0521739130434783 0.0983606557377049
REAC REAC:R-HSA-168256 Immune System 0.00372168535706332 2139 6 6 1 0.00280504908835905
REAC REAC:R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.00372168535706332 69 115 6 0.0521739130434783 0.0869565217391304
REAC REAC:R-HSA-2029481 FCGR activation 0.00372168535706332 67 115 6 0.0521739130434783 0.0895522388059701
REAC REAC:R-HSA-173623 Classical antibody-mediated complement activation 0.00372168535706332 61 115 6 0.0521739130434783 0.0983606557377049
REAC REAC:R-HSA-166663 Initial triggering of complement 0.0047871833056159 76 115 6 0.0521739130434783 0.0789473684210526
REAC REAC:R-HSA-2029485 Role of phospholipids in phagocytosis 0.00582730576735156 81 115 6 0.0521739130434783 0.0740740740740741
REAC REAC:R-HSA-70221 Glycogen breakdown (glycogenolysis) 0.00582730576735156 15 92 3 0.0326086956521739 0.2
REAC REAC:R-HSA-2871796 FCERI mediated MAPK activation 0.00582730576735156 83 115 6 0.0521739130434783 0.072289156626506
REAC REAC:R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.00582730576735156 83 115 6 0.0521739130434783 0.072289156626506
REAC REAC:R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 0.00621215558932594 85 115 6 0.0521739130434783 0.0705882352941176
REAC REAC:R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.00820930114689866 93 115 6 0.0521739130434783 0.0645161290322581
REAC REAC:R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.00820930114689866 60 28 3 0.107142857142857 0.05
REAC REAC:R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.00839697070170643 95 115 6 0.0521739130434783 0.0631578947368421
REAC REAC:R-HSA-1442490 Collagen degradation 0.00864962716113762 64 28 3 0.107142857142857 0.046875
REAC REAC:R-HSA-977606 Regulation of Complement cascade 0.00982013190902168 101 115 6 0.0521739130434783 0.0594059405940594
REAC REAC:R-HSA-5223345 Miscellaneous transport and binding events 0.00982013190902168 26 76 3 0.0394736842105263 0.115384615384615
REAC REAC:R-HSA-202733 Cell surface interactions at the vascular wall 0.0104632550150803 190 63 6 0.0952380952380952 0.0315789473684211
REAC REAC:R-HSA-9658195 Leishmania infection 0.0109140907800288 303 89 9 0.101123595505618 0.0297029702970297
REAC REAC:R-HSA-5663084 Diseases of carbohydrate metabolism 0.0109140907800288 33 64 3 0.046875 0.0909090909090909
REAC REAC:R-HSA-166658 Complement cascade 0.0136583719831541 111 115 6 0.0521739130434783 0.0540540540540541
REAC REAC:R-HSA-9664407 Parasite infection 0.0136915919716429 113 115 6 0.0521739130434783 0.0530973451327434
REAC REAC:R-HSA-9664422 FCGR3A-mediated phagocytosis 0.0136915919716429 113 115 6 0.0521739130434783 0.0530973451327434
REAC REAC:R-HSA-9664417 Leishmania phagocytosis 0.0136915919716429 113 115 6 0.0521739130434783 0.0530973451327434
REAC REAC:R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.0140549343937097 116 115 6 0.0521739130434783 0.0517241379310345
REAC REAC:R-HSA-1474290 Collagen formation 0.0140549343937097 89 28 3 0.107142857142857 0.0337078651685393
REAC REAC:R-HSA-8982491 Glycogen metabolism 0.0140549343937097 27 92 3 0.0326086956521739 0.111111111111111
REAC REAC:R-HSA-9664433 Leishmania parasite growth and survival 0.0200089753041071 221 89 7 0.0786516853932584 0.0316742081447964
REAC REAC:R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.0200089753041071 221 89 7 0.0786516853932584 0.0316742081447964
REAC REAC:R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.0259189167127849 181 115 7 0.0608695652173913 0.0386740331491713
REAC REAC:R-HSA-2871837 FCERI mediated NF-kB activation 0.0259189167127849 136 115 6 0.0521739130434783 0.0441176470588235
REAC REAC:R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.0292555877954404 140 115 6 0.0521739130434783 0.0428571428571429
REAC REAC:R-HSA-1474228 Degradation of the extracellular matrix 0.0389809849473657 140 28 3 0.107142857142857 0.0214285714285714
REAC REAC:R-HSA-195258 RHO GTPase Effectors 0.0420042715980662 283 15 3 0.2 0.0106007067137809
REAC REAC:R-HSA-1630316 Glycosaminoglycan metabolism 0.04940011138946 123 36 3 0.0833333333333333 0.024390243902439
WP WP:WP408 Oxidative Stress 0.00375988688404682 34 15 3 0.2 0.0882352941176471

pEpiTd18 transcription factor target enrichment of top program genes

TF enrichment of pEpiTd18
Possible regulators of activation of pEpiTd18 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.