pEpi43 program activity among Epithelial cells

Activation of pEpi43
pEpi43 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi43 by different cell subtypes
pEpi43 gene program activation among cells of different subtypes (Epithelial cells).

pEpi43 top program genes

Top genes of pEpi43 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi43 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi43
pEpi43 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 3.96633639599214e-13 206 141 20 0.141843971631206 0.0970873786407767
GO:BP GO:0048193 Golgi vesicle transport 3.14548709782388e-12 382 141 24 0.170212765957447 0.06282722513089
GO:BP GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 2.65043232710904e-08 87 130 11 0.0846153846153846 0.126436781609195
GO:BP GO:0009225 nucleotide-sugar metabolic process 8.41601585210769e-08 38 124 8 0.0645161290322581 0.210526315789474
GO:BP GO:0009226 nucleotide-sugar biosynthetic process 8.41601585210769e-08 23 124 7 0.0564516129032258 0.304347826086957
GO:BP GO:0046349 amino sugar biosynthetic process 7.58021218312798e-06 13 124 5 0.0403225806451613 0.384615384615385
GO:BP GO:0006047 UDP-N-acetylglucosamine metabolic process 2.16916543600082e-05 16 124 5 0.0403225806451613 0.3125
GO:BP GO:0090114 COPII-coated vesicle budding 2.86627088521038e-05 72 141 8 0.0567375886524823 0.111111111111111
GO:BP GO:0048199 vesicle targeting, to, from or within Golgi 2.86627088521038e-05 73 141 8 0.0567375886524823 0.10958904109589
GO:BP GO:0006048 UDP-N-acetylglucosamine biosynthetic process 0.00014589250510411 11 124 4 0.032258064516129 0.363636363636364
GO:BP GO:0006903 vesicle targeting 0.00014589250510411 94 141 8 0.0567375886524823 0.0851063829787234
GO:BP GO:0048208 COPII vesicle coating 0.00014589250510411 65 141 7 0.049645390070922 0.107692307692308
GO:BP GO:0048207 vesicle targeting, rough ER to cis-Golgi 0.00014589250510411 65 141 7 0.049645390070922 0.107692307692308
GO:BP GO:0006901 vesicle coating 0.000204576654192978 69 141 7 0.049645390070922 0.101449275362319
GO:BP GO:0006900 vesicle budding from membrane 0.000333986222767781 107 141 8 0.0567375886524823 0.0747663551401869
GO:BP GO:0034620 cellular response to unfolded protein 0.000418702058669623 149 141 9 0.0638297872340425 0.0604026845637584
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 0.00048122940248451 686 96 15 0.15625 0.021865889212828
GO:BP GO:0006621 protein retention in ER lumen 0.000767420236001433 9 73 3 0.0410958904109589 0.333333333333333
GO:BP GO:0035967 cellular response to topologically incorrect protein 0.000895950473177998 168 141 9 0.0638297872340425 0.0535714285714286
GO:BP GO:0030968 endoplasmic reticulum unfolded protein response 0.000912454493619082 128 141 8 0.0567375886524823 0.0625
GO:BP GO:0006040 amino sugar metabolic process 0.00116577888992986 42 124 5 0.0403225806451613 0.119047619047619
GO:BP GO:0019673 GDP-mannose metabolic process 0.00121454819756554 7 123 3 0.024390243902439 0.428571428571429
GO:BP GO:0006986 response to unfolded protein 0.00155412171487045 184 141 9 0.0638297872340425 0.0489130434782609
GO:BP GO:0034976 response to endoplasmic reticulum stress 0.0016735961113714 298 89 9 0.101123595505618 0.0302013422818792
GO:BP GO:0035437 maintenance of protein localization in endoplasmic reticulum 0.00210704914582641 14 73 3 0.0410958904109589 0.214285714285714
GO:BP GO:0046907 intracellular transport 0.00283117857387655 1767 141 30 0.212765957446809 0.0169779286926995
GO:BP GO:0035966 response to topologically incorrect protein 0.00283117857387655 205 141 9 0.0638297872340425 0.0439024390243902
GO:BP GO:0035459 vesicle cargo loading 0.00383292828739456 26 141 4 0.0283687943262411 0.153846153846154
GO:BP GO:0071702 organic substance transport 0.00396636303508095 2766 141 40 0.283687943262411 0.0144613159797542
GO:BP GO:0042886 amide transport 0.00445036007071415 2007 141 32 0.226950354609929 0.0159441953163926
GO:BP GO:0006820 anion transport 0.00448858916688493 2889 141 41 0.290780141843972 0.0141917618553133
GO:BP GO:0015031 protein transport 0.00474369955797204 1929 141 31 0.219858156028369 0.0160705028512182
GO:BP GO:0006811 ion transport 0.0057595723240569 3661 141 48 0.340425531914894 0.0131111718109806
GO:BP GO:0009101 glycoprotein biosynthetic process 0.00641034475908879 347 96 9 0.09375 0.0259365994236311
GO:BP GO:0015833 peptide transport 0.00648832555532865 1971 141 31 0.219858156028369 0.0157280568239472
GO:BP GO:0006891 intra-Golgi vesicle-mediated transport 0.00862664806466524 37 130 4 0.0307692307692308 0.108108108108108
GO:BP GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.00862664806466524 63 29 3 0.103448275862069 0.0476190476190476
GO:BP GO:0045184 establishment of protein localization 0.00980402679534961 2035 141 31 0.219858156028369 0.0152334152334152
GO:BP GO:0071705 nitrogen compound transport 0.00980402679534961 2322 141 34 0.24113475177305 0.0146425495262705
GO:BP GO:0036498 IRE1-mediated unfolded protein response 0.00980402679534961 67 141 5 0.0354609929078014 0.0746268656716418
GO:BP GO:0090110 COPII-coated vesicle cargo loading 0.0106670297676661 15 141 3 0.0212765957446809 0.2
GO:BP GO:0030162 regulation of proteolysis 0.0141568728562662 752 4 3 0.75 0.00398936170212766
GO:BP GO:0016192 vesicle-mediated transport 0.0141568728562662 2180 141 32 0.226950354609929 0.0146788990825688
GO:BP GO:0051650 establishment of vesicle localization 0.0141568728562662 214 141 8 0.0567375886524823 0.0373831775700935
GO:BP GO:1901135 carbohydrate derivative metabolic process 0.0143199027463474 1145 124 19 0.153225806451613 0.0165938864628821
GO:BP GO:0043413 macromolecule glycosylation 0.0159896692493237 251 124 8 0.0645161290322581 0.0318725099601594
GO:BP GO:0006486 protein glycosylation 0.0159896692493237 251 124 8 0.0645161290322581 0.0318725099601594
GO:BP GO:0034613 cellular protein localization 0.0159896692493237 2014 141 30 0.212765957446809 0.0148957298907646
GO:BP GO:0070727 cellular macromolecule localization 0.0169497633980172 2024 141 30 0.212765957446809 0.0148221343873518
GO:BP GO:1901071 glucosamine-containing compound metabolic process 0.0173762872893206 27 96 3 0.03125 0.111111111111111
GO:BP GO:0009100 glycoprotein metabolic process 0.0184750974228913 424 96 9 0.09375 0.0212264150943396
GO:BP GO:0051648 vesicle localization 0.0190481418351097 230 141 8 0.0567375886524823 0.0347826086956522
GO:BP GO:0006810 transport 0.0190481418351097 5224 131 56 0.427480916030534 0.0107197549770291
GO:BP GO:0070085 glycosylation 0.0195548680174945 264 124 8 0.0645161290322581 0.0303030303030303
GO:BP GO:0007030 Golgi organization 0.0197268690547576 147 122 6 0.0491803278688525 0.0408163265306122
GO:BP GO:0030433 ubiquitin-dependent ERAD pathway 0.0220523954542602 82 83 4 0.0481927710843374 0.0487804878048781
GO:BP GO:0007029 endoplasmic reticulum organization 0.023092262928554 87 141 5 0.0354609929078014 0.0574712643678161
GO:BP GO:0071577 zinc ion transmembrane transport 0.0242464491460641 25 127 3 0.0236220472440945 0.12
GO:BP GO:0072595 maintenance of protein localization in organelle 0.0242464491460641 43 73 3 0.0410958904109589 0.0697674418604651
GO:BP GO:0051640 organelle localization 0.0250731815854081 668 141 14 0.099290780141844 0.0209580838323353
GO:BP GO:0006886 intracellular protein transport 0.0256212973166234 1186 130 19 0.146153846153846 0.0160202360876897
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.0256212973166234 1082 4 3 0.75 0.00277264325323475
GO:BP GO:0050878 regulation of body fluid levels 0.0266398733542622 514 88 9 0.102272727272727 0.0175097276264591
GO:BP GO:0051234 establishment of localization 0.0271325733014901 5372 131 56 0.427480916030534 0.0104244229337305
GO:BP GO:0070972 protein localization to endoplasmic reticulum 0.0271325733014901 146 140 6 0.0428571428571429 0.0410958904109589
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0273497302965734 1151 4 3 0.75 0.00260642919200695
GO:BP GO:0006829 zinc ion transport 0.029878143296766 29 127 3 0.0236220472440945 0.103448275862069
GO:BP GO:0036503 ERAD pathway 0.0302459026891146 103 36 3 0.0833333333333333 0.029126213592233
GO:BP GO:0051649 establishment of localization in cell 0.0316524671766691 2813 130 34 0.261538461538462 0.0120867401350871
GO:BP GO:0016050 vesicle organization 0.036355584066579 341 141 9 0.0638297872340425 0.0263929618768328
GO:BP GO:0032527 protein exit from endoplasmic reticulum 0.040576809217874 48 89 3 0.0337078651685393 0.0625
GO:BP GO:0006487 protein N-linked glycosylation 0.042890230008131 76 124 4 0.032258064516129 0.0526315789473684
GO:BP GO:0008104 protein localization 0.0451985962484172 2770 141 35 0.24822695035461 0.0126353790613718
GO:BP GO:0000041 transition metal ion transport 0.0453513052527347 129 127 5 0.0393700787401575 0.0387596899224806
GO:BP GO:0032507 maintenance of protein location in cell 0.0475942168174386 67 73 3 0.0410958904109589 0.0447761194029851
GO:BP GO:0051656 establishment of organelle localization 0.0483314790605753 445 141 10 0.0709219858156028 0.0224719101123595
GO:BP GO:0006904 vesicle docking involved in exocytosis 0.0496754685399301 46 109 3 0.0275229357798165 0.0652173913043478
GO:CC GO:0000139 Golgi membrane 5.42456160793711e-14 771 141 33 0.234042553191489 0.0428015564202335
GO:CC GO:0005794 Golgi apparatus 3.82906019187412e-13 1623 141 45 0.319148936170213 0.0277264325323475
GO:CC GO:0098791 Golgi apparatus subcompartment 9.71858291058489e-13 885 141 33 0.234042553191489 0.0372881355932203
GO:CC GO:0031984 organelle subcompartment 4.78410119971211e-12 1773 141 45 0.319148936170213 0.0253807106598985
GO:CC GO:0030137 COPI-coated vesicle 8.81644554936926e-12 28 130 9 0.0692307692307692 0.321428571428571
GO:CC GO:0030663 COPI-coated vesicle membrane 8.81644554936926e-12 18 130 8 0.0615384615384615 0.444444444444444
GO:CC GO:0030133 transport vesicle 1.87464103906063e-10 414 141 21 0.148936170212766 0.0507246376811594
GO:CC GO:0012505 endomembrane system 3.2490265169055e-10 4640 141 72 0.51063829787234 0.0155172413793103
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 8.05677933039941e-09 1139 141 31 0.219858156028369 0.0272168568920105
GO:CC GO:0098827 endoplasmic reticulum subcompartment 1.84451248802271e-08 1122 141 30 0.212765957446809 0.0267379679144385
GO:CC GO:0030135 coated vesicle 1.84451248802271e-08 295 141 16 0.113475177304965 0.0542372881355932
GO:CC GO:0030662 coated vesicle membrane 1.84451248802271e-08 177 141 13 0.0921985815602837 0.0734463276836158
GO:CC GO:0005789 endoplasmic reticulum membrane 1.84451248802271e-08 1117 141 30 0.212765957446809 0.026857654431513
GO:CC GO:0030660 Golgi-associated vesicle membrane 5.34700940153397e-08 52 130 8 0.0615384615384615 0.153846153846154
GO:CC GO:0098588 bounding membrane of organelle 5.46414254869238e-08 2158 141 42 0.297872340425532 0.0194624652455978
GO:CC GO:0005783 endoplasmic reticulum 1.71734766905776e-07 1982 141 39 0.276595744680851 0.0196770938446014
GO:CC GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 2.22211511718302e-07 131 121 10 0.0826446280991736 0.0763358778625954
GO:CC GO:0030126 COPI vesicle coat 2.96386881106711e-07 13 130 5 0.0384615384615385 0.384615384615385
GO:CC GO:0005798 Golgi-associated vesicle 2.96386881106711e-07 94 130 9 0.0692307692307692 0.0957446808510638
GO:CC GO:0030120 vesicle coat 2.65936683069851e-06 55 141 7 0.049645390070922 0.127272727272727
GO:CC GO:0031090 organelle membrane 7.90056187793294e-06 3612 141 52 0.368794326241135 0.0143964562569214
GO:CC GO:0031982 vesicle 2.48571203011382e-05 4055 89 39 0.438202247191011 0.00961775585696671
GO:CC GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane 3.85334670132025e-05 74 101 6 0.0594059405940594 0.0810810810810811
GO:CC GO:0070971 endoplasmic reticulum exit site 4.18427101697784e-05 31 141 5 0.0354609929078014 0.161290322580645
GO:CC GO:0030134 COPII-coated ER to Golgi transport vesicle 5.84147814805073e-05 90 141 7 0.049645390070922 0.0777777777777778
GO:CC GO:0031410 cytoplasmic vesicle 5.84147814805073e-05 2424 141 38 0.269503546099291 0.0156765676567657
GO:CC GO:0097708 intracellular vesicle 5.84147814805073e-05 2428 141 38 0.269503546099291 0.0156507413509061
GO:CC GO:0030117 membrane coat 8.95555078254993e-05 97 141 7 0.049645390070922 0.0721649484536082
GO:CC GO:0048475 coated membrane 8.95555078254993e-05 97 141 7 0.049645390070922 0.0721649484536082
GO:CC GO:0016020 membrane 0.000131708410018787 9838 134 94 0.701492537313433 0.00955478755844684
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.000204628063310107 779 141 18 0.127659574468085 0.0231065468549422
GO:CC GO:0012506 vesicle membrane 0.000281781705859063 800 141 18 0.127659574468085 0.0225
GO:CC GO:0012507 ER to Golgi transport vesicle membrane 0.000642150984692742 57 141 5 0.0354609929078014 0.087719298245614
GO:CC GO:0005737 cytoplasm 0.00140780178508186 11911 138 107 0.77536231884058 0.00898329275459659
GO:CC GO:0005801 cis-Golgi network 0.00468350265618858 69 101 4 0.0396039603960396 0.0579710144927536
GO:CC GO:0070062 extracellular exosome 0.00724302957624362 2176 88 21 0.238636363636364 0.00965073529411765
GO:CC GO:0030658 transport vesicle membrane 0.0078164323313129 209 101 6 0.0594059405940594 0.0287081339712919
GO:CC GO:1903561 extracellular vesicle 0.0110798206008119 2261 88 21 0.238636363636364 0.00928792569659443
GO:CC GO:0043230 extracellular organelle 0.0110798206008119 2263 88 21 0.238636363636364 0.00927971718957137
GO:CC GO:0005788 endoplasmic reticulum lumen 0.0161825775466317 307 140 8 0.0571428571428571 0.0260586319218241
GO:CC GO:0099503 secretory vesicle 0.0176977023589523 1020 134 16 0.119402985074627 0.0156862745098039
GO:CC GO:0005615 extracellular space 0.0202343931367699 3594 88 28 0.318181818181818 0.00779076238174736
GO:CC GO:0030141 secretory granule 0.0294914705272377 851 125 13 0.104 0.0152761457109283
GO:CC GO:0070382 exocytic vesicle 0.0401810913375145 229 134 6 0.0447761194029851 0.0262008733624454
GO:CC GO:0048770 pigment granule 0.0443898105418405 105 136 4 0.0294117647058824 0.0380952380952381
GO:CC GO:0042470 melanosome 0.0443898105418405 105 136 4 0.0294117647058824 0.0380952380952381
GO:MF GO:0005046 KDEL sequence binding 2.58409465009423e-05 3 73 3 0.0410958904109589 1
GO:MF GO:0046923 ER retention sequence binding 0.000128479276305504 5 73 3 0.0410958904109589 0.6
GO:MF GO:0004867 serine-type endopeptidase inhibitor activity 0.00579857874654323 98 13 3 0.230769230769231 0.0306122448979592
GO:MF GO:0004866 endopeptidase inhibitor activity 0.0171732078471175 176 13 3 0.230769230769231 0.0170454545454545
GO:MF GO:0061135 endopeptidase regulator activity 0.0171732078471175 188 13 3 0.230769230769231 0.0159574468085106
GO:MF GO:0030414 peptidase inhibitor activity 0.0171732078471175 182 13 3 0.230769230769231 0.0164835164835165
GO:MF GO:0005048 signal sequence binding 0.0171732078471175 49 118 4 0.0338983050847458 0.0816326530612245
GO:MF GO:0005385 zinc ion transmembrane transporter activity 0.0183015014840416 23 127 3 0.0236220472440945 0.130434782608696
GO:MF GO:0030331 estrogen receptor binding 0.0183015014840416 44 67 3 0.0447761194029851 0.0681818181818182
GO:MF GO:0051787 misfolded protein binding 0.0183015014840416 28 95 3 0.0315789473684211 0.107142857142857
GO:MF GO:0032549 ribonucleoside binding 0.0275000029171849 389 135 9 0.0666666666666667 0.0231362467866324
GO:MF GO:0032550 purine ribonucleoside binding 0.0275000029171849 386 135 9 0.0666666666666667 0.0233160621761658
GO:MF GO:0046915 transition metal ion transmembrane transporter activity 0.0275000029171849 39 127 3 0.0236220472440945 0.0769230769230769
GO:MF GO:0016853 isomerase activity 0.0275000029171849 169 98 5 0.0510204081632653 0.029585798816568
GO:MF GO:0030246 carbohydrate binding 0.0275000029171849 275 81 6 0.0740740740740741 0.0218181818181818
GO:MF GO:0001883 purine nucleoside binding 0.0275000029171849 389 135 9 0.0666666666666667 0.0231362467866324
GO:MF GO:0015144 carbohydrate transmembrane transporter activity 0.0275000029171849 38 131 3 0.0229007633587786 0.0789473684210526
GO:MF GO:0005525 GTP binding 0.0275000029171849 381 135 9 0.0666666666666667 0.0236220472440945
GO:MF GO:0001882 nucleoside binding 0.0275000029171849 395 135 9 0.0666666666666667 0.0227848101265823
GO:MF GO:0003924 GTPase activity 0.0275000029171849 328 122 8 0.0655737704918033 0.024390243902439
GO:MF GO:0019001 guanyl nucleotide binding 0.0286414101919141 403 135 9 0.0666666666666667 0.0223325062034739
GO:MF GO:0032561 guanyl ribonucleotide binding 0.0286414101919141 403 135 9 0.0666666666666667 0.0223325062034739
GO:MF GO:0004252 serine-type endopeptidase activity 0.0288242757034691 171 64 4 0.0625 0.0233918128654971
GO:MF GO:0035258 steroid hormone receptor binding 0.0318556527207566 82 67 3 0.0447761194029851 0.0365853658536585
GO:MF GO:0008236 serine-type peptidase activity 0.0342289941216067 189 64 4 0.0625 0.0211640211640212
GO:MF GO:0017171 serine hydrolase activity 0.0360525594600435 193 64 4 0.0625 0.0207253886010363
GO:MF GO:0098772 molecular function regulator 0.0380044169952492 2363 14 6 0.428571428571429 0.00253914515446466
GO:MF GO:0008509 anion transmembrane transporter activity 0.0391477454234711 464 131 9 0.0687022900763359 0.0193965517241379
GO:MF GO:0042887 amide transmembrane transporter activity 0.0408864750619303 58 118 3 0.0254237288135593 0.0517241379310345
GO:MF GO:0016922 nuclear receptor binding 0.0429054619936944 105 67 3 0.0447761194029851 0.0285714285714286
KEGG KEGG:00520 Amino sugar and nucleotide sugar metabolism 4.50523099051826e-06 48 124 9 0.0725806451612903 0.1875
KEGG KEGG:04141 Protein processing in endoplasmic reticulum 0.0469399250953602 170 141 10 0.0709219858156028 0.0588235294117647
REAC REAC:R-HSA-446203 Asparagine N-linked glycosylation 1.05228291471803e-16 304 141 31 0.219858156028369 0.101973684210526
REAC REAC:R-HSA-199977 ER to Golgi Anterograde Transport 2.7456451916815e-10 154 141 18 0.127659574468085 0.116883116883117
REAC REAC:R-HSA-948021 Transport to the Golgi and subsequent modification 4.39951215390482e-10 185 141 19 0.134751773049645 0.102702702702703
REAC REAC:R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 1.08597620592139e-08 63 124 11 0.0887096774193548 0.174603174603175
REAC REAC:R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 9.46105791208328e-08 78 124 11 0.0887096774193548 0.141025641025641
REAC REAC:R-HSA-6807878 COPI-mediated anterograde transport 2.33281214628559e-06 102 130 11 0.0846153846153846 0.107843137254902
REAC REAC:R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 1.72439745840403e-05 100 130 10 0.0769230769230769 0.1
REAC REAC:R-HSA-8856688 Golgi-to-ER retrograde transport 2.89225938970549e-05 134 130 11 0.0846153846153846 0.082089552238806
REAC REAC:R-HSA-597592 Post-translational protein modification 3.48247108431237e-05 1377 141 40 0.283687943262411 0.0290486564996369
REAC REAC:R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 3.82676310001724e-05 8 124 4 0.032258064516129 0.5
REAC REAC:R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.000209026535690507 203 130 12 0.0923076923076923 0.0591133004926108
REAC REAC:R-HSA-392499 Metabolism of proteins 0.000500178931305196 1961 141 47 0.333333333333333 0.0239673635900051
REAC REAC:R-HSA-204005 COPII-mediated vesicle transport 0.000702085260976206 67 141 7 0.049645390070922 0.104477611940299
REAC REAC:R-HSA-5694530 Cargo concentration in the ER 0.00150233372469531 33 140 5 0.0357142857142857 0.151515151515152
REAC REAC:R-HSA-199991 Membrane Trafficking 0.00468871111866328 625 141 20 0.141843971631206 0.032
REAC REAC:R-HSA-5653656 Vesicle-mediated transport 0.0209947209184383 717 141 20 0.141843971631206 0.0278940027894003
REAC REAC:R-HSA-381119 Unfolded Protein Response (UPR) 0.0209947209184383 91 141 6 0.0425531914893617 0.0659340659340659
REAC REAC:R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 0.0231623039215443 124 20 3 0.15 0.0241935483870968
REAC REAC:R-HSA-4085001 Sialic acid metabolism 0.0385529296793241 33 90 3 0.0333333333333333 0.0909090909090909
REAC REAC:R-HSA-381038 XBP1(S) activates chaperone genes 0.0453745102113559 47 141 4 0.0283687943262411 0.0851063829787234
TF TF:M11250 Factor: Luman; motif: NGCCACGTCAYN 8.6510728491702e-09 223 89 14 0.157303370786517 0.062780269058296
TF TF:M11227 Factor: ATF-6; motif: TGRTGACGTGGCAN 4.54786498060321e-08 201 140 15 0.107142857142857 0.0746268656716418
TF TF:M11256 Factor: AIBZIP; motif: NGCCACGTCAYN 6.51075258819619e-08 1323 140 34 0.242857142857143 0.0256991685563114
TF TF:M11229 Factor: ATF-6; motif: TGRTGACGTGGCAN 6.51075258819619e-08 342 140 18 0.128571428571429 0.0526315789473684
TF TF:M11247 Factor: Luman; motif: YGCCACGTCAYC 1.59908587836695e-07 174 131 13 0.099236641221374 0.0747126436781609
TF TF:M11230 Factor: CREBL1; motif: YGCCACGTCAYC 1.59908587836695e-07 56 89 8 0.0898876404494382 0.142857142857143
TF TF:M11276 Factor: XBP-1; motif: NNMCACGTCANN 3.05102690824561e-07 551 140 21 0.15 0.0381125226860254
TF TF:M11235 Factor: OASIS; motif: YGCCACGTCANC 3.05102690824561e-07 368 131 17 0.129770992366412 0.046195652173913
TF TF:M11256_1 Factor: AIBZIP; motif: NGCCACGTCAYN; match class: 1 1.65633196021454e-06 75 136 9 0.0661764705882353 0.12
TF TF:M11253 Factor: AIBZIP; motif: YGCCACGTCACC 4.33594965957336e-06 229 89 11 0.123595505617978 0.0480349344978166
TF TF:M04207 Factor: CREB3; motif: NTGCCACGTCAYCN 1.65627831135734e-05 41 89 6 0.0674157303370786 0.146341463414634
TF TF:M11238 Factor: OASIS; motif: TGCCACGTCAYC 0.000164549408069218 32 89 5 0.0561797752808989 0.15625
TF TF:M10097_1 Factor: AP-4; motif: YCAGCTGNKN; match class: 1 0.000313740867641444 1554 114 26 0.228070175438596 0.0167310167310167
TF TF:M03906 Factor: HIC2; motif: RTGCCCRNN 0.000326702297397491 3458 50 24 0.48 0.00694042799305957
TF TF:M10172_1 Factor: HKR2; motif: NGNCNGAGGGMGGAGG; match class: 1 0.00045272843806676 165 64 7 0.109375 0.0424242424242424
TF TF:M00483 Factor: ATF6; motif: TGACGTGG 0.000571477780787679 2627 61 23 0.377049180327869 0.00875523410734678
TF TF:M11244 Factor: OASIS; motif: YGCCACGTCAYC 0.000571477780787679 19 89 4 0.0449438202247191 0.210526315789474
TF TF:M09734_1 Factor: ZNF692; motif: SYNGGSCCCASCCNC; match class: 1 0.00150756985949183 6255 96 52 0.541666666666667 0.00831334932054357
TF TF:M06667 Factor: ZNF599; motif: KGGTTCAGGAGM 0.00400572017158525 25 113 4 0.0353982300884956 0.16
TF TF:M00446 Factor: Spz1; motif: DNNGGRGGGWWNNNN 0.00517184765600291 8655 89 59 0.662921348314607 0.00681686886192952
TF TF:M03814_1 Factor: BTEB2; motif: GNAGGGGGNGGGSSNN; match class: 1 0.00517184765600291 1300 89 18 0.202247191011236 0.0138461538461538
TF TF:M11274 Factor: XBP-1; motif: NGMCACRTCAYC 0.00749921416085491 1759 82 20 0.24390243902439 0.0113700966458215
TF TF:M00008 Factor: Sp1; motif: GGGGCGGGGT 0.00759898180517448 10055 141 96 0.680851063829787 0.00954748881153655
TF TF:M07277 Factor: BTEB2; motif: RGGGNGKGGN 0.00796563749243023 8492 75 50 0.666666666666667 0.00588789448893076
TF TF:M07248 Factor: CREB1; motif: NNNNTGACGTNANNN 0.00796563749243023 4266 62 28 0.451612903225806 0.00656352555086732
TF TF:M09898 Factor: Egr-2; motif: GNGRRNGWGKGGGNGGRG 0.00990901249905152 6484 140 69 0.492857142857143 0.0106415792720543
TF TF:M07608 Factor: NFAT; motif: NNGGAAAAN 0.0113105604870574 714 3 3 1 0.00420168067226891
TF TF:M01770_1 Factor: XBP-1; motif: WNNGMCACGTC; match class: 1 0.0116060101913153 4554 113 45 0.398230088495575 0.00988142292490119
TF TF:M04228 Factor: XBP1; motif: WNNGMCACGTCATC 0.0116363565179458 57 140 5 0.0357142857142857 0.087719298245614
TF TF:M11246 Factor: OASIS; motif: YGCCACGTRNNCN 0.0150596963083389 207 130 8 0.0615384615384615 0.0386473429951691
TF TF:M01770 Factor: XBP-1; motif: WNNGMCACGTC 0.0156986129750952 11003 141 101 0.716312056737589 0.00917931473234572
TF TF:M10071 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG 0.0158452991621797 8495 140 83 0.592857142857143 0.00977045320776928
TF TF:M07034 Factor: ATF-1; motif: NNNTGACGTNNN 0.0163222984603087 4248 62 27 0.435483870967742 0.00635593220338983
TF TF:M07261_1 Factor: LKLF; motif: GGGGTGGKSN; match class: 1 0.0168173412080274 4062 85 33 0.388235294117647 0.00812407680945347
TF TF:M01588_1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 0.0170385673341499 3962 131 45 0.343511450381679 0.0113579000504796
TF TF:M12160_1 Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1 0.0179948622985379 8031 75 47 0.626666666666667 0.0058523222512763
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.018125881820771 7728 140 77 0.55 0.00996376811594203
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.0186088802645004 10640 141 98 0.695035460992908 0.00921052631578947
TF TF:M07615 Factor: Sp3; motif: GGGGCGGGGSNN 0.0186088802645004 6807 140 70 0.5 0.0102835316585867
TF TF:M02075 Factor: PDEF; motif: MCCGGATNTN 0.01945693020473 2666 101 28 0.277227722772277 0.0105026256564141
TF TF:M09969 Factor: EKLF; motif: NGGGYGKGGCNNGG 0.01945693020473 4589 129 49 0.37984496124031 0.0106777075615603
TF TF:M09729 Factor: LUMAN; motif: CYCAGCYYCY 0.0197931050409961 10686 50 40 0.8 0.00374321542204754
TF TF:M12186_1 Factor: BTEB4; motif: NCCACGCCCM; match class: 1 0.0202122871476258 3958 137 46 0.335766423357664 0.011622031328954
TF TF:M07277_1 Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 0.0202122871476258 4149 75 30 0.4 0.00723065798987708
TF TF:M11274_1 Factor: XBP-1; motif: NGMCACRTCAYC; match class: 1 0.0202122871476258 109 89 5 0.0561797752808989 0.0458715596330275
TF TF:M07474_1 Factor: Tbx20; motif: SGAGGTGTGAGGSGR; match class: 1 0.0202122871476258 477 12 4 0.333333333333333 0.00838574423480084
TF TF:M07409 Factor: BTEB2; motif: GCCCCRCCCH 0.020264547518709 5198 131 54 0.412213740458015 0.0103886110042324
TF TF:M07063 Factor: Sp1; motif: GGGGCGGGGC 0.0216511611433223 7696 140 76 0.542857142857143 0.00987525987525988
TF TF:M00039 Factor: CREB; motif: TGACGTMA 0.0216511611433223 5222 62 30 0.483870967741935 0.00574492531597089
TF TF:M10435 Factor: Sp2; motif: GGGGCGGGG 0.0216511611433223 7696 140 76 0.542857142857143 0.00987525987525988
TF TF:M09723_1 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 0.0216511611433223 6113 140 64 0.457142857142857 0.0104694912481597
TF TF:M07341_1 Factor: TORC2; motif: TGGGCTKKD; match class: 1 0.0216511611433223 884 13 5 0.384615384615385 0.00565610859728507
TF TF:M00466 Factor: HIF1; motif: NGTACGTGCNGB 0.0216511611433223 2997 16 9 0.5625 0.003003003003003
TF TF:M04595_1 Factor: SALL2; motif: GGGTGGG; match class: 1 0.0264769241568332 7373 91 51 0.56043956043956 0.0069171300691713
TF TF:M00917 Factor: CREB; motif: CNNTGACGTMA 0.0276747159068808 5578 62 31 0.5 0.00555754750806741
TF TF:M00196_1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 0.0276747159068808 5919 140 62 0.442857142857143 0.0104747423551276
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.0279615107853427 10233 141 94 0.666666666666667 0.00918596696960813
TF TF:M01808_1 Factor: NMYC; motif: CAYCTG; match class: 1 0.0279615107853427 6149 32 20 0.625 0.00325256139209628
TF TF:M07461_1 Factor: KLF; motif: GGGNGGGG; match class: 1 0.0279615107853427 3397 84 28 0.333333333333333 0.00824256697085664
TF TF:M09972_1 Factor: BTEB2; motif: WGGGTGKGGCNGGN; match class: 1 0.0280549764223892 3919 74 28 0.378378378378378 0.00714467976524624
TF TF:M11219 Factor: CREB1; motif: NRTGACGTR 0.0285087339536609 873 60 10 0.166666666666667 0.011454753722795
TF TF:M00733_1 Factor: SMAD4; motif: GKSRKKCAGMCANCY; match class: 1 0.0285087339536609 2823 120 32 0.266666666666667 0.0113354587318456
TF TF:M00075_1 Factor: GATA-1; motif: SNNGATNNNN; match class: 1 0.0287666960828153 1673 94 19 0.202127659574468 0.0113568439928273
TF TF:M09892_1 Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 0.0287666960828153 9162 100 64 0.64 0.00698537437240777
TF TF:M01118 Factor: WT1; motif: SMCNCCNSC 0.0287666960828153 6808 89 47 0.528089887640449 0.00690364277320799
TF TF:M03920 Factor: SP1; motif: RCCMCRCCCMC 0.0312635416323813 7283 138 71 0.514492753623188 0.00974872991898943
TF TF:M07129_1 Factor: Sp2; motif: GYCCCGCCYCYNNNN; match class: 1 0.0312635416323813 2422 140 32 0.228571428571429 0.0132122213047069
TF TF:M03544 Factor: CREB1; motif: NNNNACGTCANN 0.0314242934807386 4101 62 25 0.403225806451613 0.0060960741282614
TF TF:M07349 Factor: AP-2gamma; motif: NNNNWGCCYNCRGSCN 0.0314242934807386 3333 22 11 0.5 0.0033003300330033
TF TF:M10071_1 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 0.0314242934807386 4623 140 51 0.364285714285714 0.0110317975340688
TF TF:M03567 Factor: Sp2; motif: NYSGCCCCGCCCCCY 0.0314242934807386 7710 140 75 0.535714285714286 0.00972762645914397
TF TF:M07040_1 Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1 0.0315916905509049 8156 113 65 0.575221238938053 0.00796959293771457
TF TF:M01587_1 Factor: FPM315; motif: SRGGGAGGAGGN; match class: 1 0.0315916905509049 546 64 8 0.125 0.0146520146520147
TF TF:M00450_1 Factor: Zic3; motif: NGGGKGGTC; match class: 1 0.0319186041607348 7927 57 36 0.631578947368421 0.00454144064589378
TF TF:M08872 Factor: DEC; motif: NNNSCACSTGAS 0.0319186041607348 7422 8 8 1 0.00107787658313123
TF TF:M01861 Factor: ATF-1; motif: TNACGTCAN 0.0319186041607348 6294 62 33 0.532258064516129 0.00524308865586273
TF TF:M01308 Factor: Sox-4; motif: AACAAWGR 0.0319186041607348 1653 61 14 0.229508196721311 0.00846944948578342
TF TF:M00931_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.0319186041607348 5905 140 61 0.435714285714286 0.0103302286198137
TF TF:M00778 Factor: AhR; motif: NTNGCGTGNNN 0.0319186041607348 3526 10 7 0.7 0.00198525241066364
TF TF:M08879_1 Factor: ER71; motif: AANAACAGGAARNN; match class: 1 0.0319186041607348 30 95 3 0.0315789473684211 0.1
TF TF:M07041_1 Factor: HDAC1; motif: KGCARGGTC; match class: 1 0.0319186041607348 6354 118 56 0.474576271186441 0.00881334592382751
TF TF:M09727_1 Factor: GEMIN3; motif: NCWGGRARRGRGNGNG; match class: 1 0.0327682721996619 3210 100 30 0.3 0.00934579439252336
TF TF:M00932_1 Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 0.0329656600047396 6047 140 62 0.442857142857143 0.0102530180254672
TF TF:M01783 Factor: SP2; motif: GGGCGGGAC 0.0329656600047396 9148 114 71 0.62280701754386 0.00776125929164845
TF TF:M07354 Factor: Egr-1; motif: GCGGGGGCGG 0.0332945443361353 7801 116 64 0.551724137931034 0.00820407640046148
TF TF:M00646_1 Factor: LF-A1; motif: GGGSTCWR; match class: 1 0.0332945443361353 6320 14 11 0.785714285714286 0.00174050632911392
TF TF:M00933_1 Factor: Sp1; motif: CCCCGCCCCN; match class: 1 0.0332945443361353 5166 140 55 0.392857142857143 0.0106465350367789
TF TF:M12354_1 Factor: ZNF37A; motif: CCYYGGCTCCNTSCCMN; match class: 1 0.0334142378510738 5624 124 53 0.42741935483871 0.00942389758179232
TF TF:M00179 Factor: ATF2; motif: VGTGACGTMACN 0.0335489427502598 6065 62 32 0.516129032258065 0.00527617477328937
TF TF:M03807_1 Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 0.0342630222164382 4199 140 47 0.335714285714286 0.011193141224101
TF TF:M01865_1 Factor: BTEB3; motif: BNRNGGGAGGNGT; match class: 1 0.0344101924001811 4218 89 33 0.370786516853933 0.00782361308677098
TF TF:M00346 Factor: GATA-1; motif: NCWGATAACA 0.0353830813160327 4376 5 5 1 0.00114259597806216
TF TF:M09973_1 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 0.0353830813160327 6607 140 66 0.471428571428571 0.00998940517632814
TF TF:M07141 Factor: FPM315; motif: GGAGGAGGRRGRGGRGGRRGR 0.0353830813160327 2175 71 18 0.253521126760563 0.00827586206896552
TF TF:M01873 Factor: Egr-1; motif: GCGGGGGCGG 0.0353830813160327 6738 140 67 0.478571428571429 0.00994360344315821
TF TF:M00483_1 Factor: ATF6; motif: TGACGTGG; match class: 1 0.0353920967877054 246 54 5 0.0925925925925926 0.0203252032520325
TF TF:M00981 Factor: CREB,; motif: NTGACGTNA 0.0353920967877054 8345 63 40 0.634920634920635 0.00479328939484721
TF TF:M09600 Factor: CREB1; motif: TKACGTCAYNN 0.0353920967877054 5324 67 31 0.462686567164179 0.00582268970698723
TF TF:M10072_1 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 0.0355161791733254 6225 140 63 0.45 0.0101204819277108
TF TF:M00979_1 Factor: Pax-6; motif: CTGACCTGGAACTM; match class: 1 0.0363273476291729 3068 4 4 1 0.00130378096479791
TF TF:M10115_1 Factor: LRF; motif: NRGGGKCKY; match class: 1 0.0366212217496534 2326 84 21 0.25 0.00902837489251935
TF TF:M03920_1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 0.0372763324097828 3020 137 36 0.262773722627737 0.0119205298013245
TF TF:M12173 Factor: GKLF; motif: NNCCMCRCCCN 0.0372763324097828 10023 139 90 0.647482014388489 0.00897934750074828
TF TF:M00797 Factor: HIF1; motif: GNNKACGTGCGGNN 0.0373637132941392 3576 13 8 0.615384615384615 0.00223713646532438
TF TF:M05775 Factor: ZXDL; motif: NGGGGWS 0.0383126948131989 6964 120 60 0.5 0.00861573808156232
TF TF:M00916 Factor: CREB; motif: NNTKACGTCANNNS 0.0383126948131989 5889 67 33 0.492537313432836 0.00560366785532348
TF TF:M08819_1 Factor: LKLF; motif: CNCCACCCS; match class: 1 0.0384666695665261 1532 84 16 0.19047619047619 0.010443864229765
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.0384666695665261 6260 140 63 0.45 0.0100638977635783
TF TF:M09790 Factor: TWIST1; motif: NNNCCAGATGTNN 0.0385936575492008 2903 51 17 0.333333333333333 0.00585601102307957
TF TF:M03807 Factor: SP2; motif: GNNGGGGGCGGGGSN 0.0389985650712355 8415 140 79 0.564285714285714 0.00938799762329174
TF TF:M01219 Factor: SP1:SP3; motif: CCSCCCCCYCC 0.0389985650712355 6812 113 56 0.495575221238938 0.00822078684674104
TF TF:M01588 Factor: GKLF; motif: GCCMCRCCCNNN 0.0399941768925554 8944 129 77 0.596899224806202 0.00860912343470483
TF TF:M08001 Factor: NFATC3; motif: WNTTTCCRNN 0.040749028214004 1783 3 3 1 0.00168255748738082
TF TF:M02012 Factor: HIF-1alpha; motif: NCACGT 0.0419998304777045 6648 14 11 0.785714285714286 0.0016546329723225
TF TF:M10026_1 Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN; match class: 1 0.0421379817352947 4894 140 52 0.371428571428571 0.0106252554147936
TF TF:M00175 Factor: AP-4; motif: VDCAGCTGNN 0.042419229613672 2471 132 30 0.227272727272727 0.0121408336705787
TF TF:M12351_1 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 0.0431789098213234 8180 111 63 0.567567567567568 0.00770171149144254
TF TF:M07208 Factor: EGR1; motif: NCNCCGCCCCCGCN 0.0450349343581039 6183 140 62 0.442857142857143 0.0100274947436519
TF TF:M03876_1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 0.0483057651988693 9106 124 75 0.604838709677419 0.0082363276960246
TF TF:M06191_1 Factor: ZXDB; motif: NGGGGTC; match class: 1 0.0483057651988693 1279 84 14 0.166666666666667 0.0109460516028147
TF TF:M10098_1 Factor: DP-1; motif: NRNNGGCGGGAANN; match class: 1 0.0483057651988693 2168 99 22 0.222222222222222 0.0101476014760148
TF TF:M06190_1 Factor: ZXDA; motif: NGGGGTC; match class: 1 0.0483057651988693 1279 84 14 0.166666666666667 0.0109460516028147
TF TF:M09765 Factor: SP1; motif: NRGKGGGCGGGGCN 0.0483057651988693 7469 141 72 0.51063829787234 0.00963984469139108
TF TF:M01837_1 Factor: FKLF; motif: BGGGNGGVMD; match class: 1 0.0497361364920044 1413 140 21 0.15 0.0148619957537155

pEpi43 transcription factor target enrichment of top program genes

TF enrichment of pEpi43
Possible regulators of activation of pEpi43 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.