pEpiTd19 program activity among Epithelial cells

Activation of pEpiTd19
pEpiTd19 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTd19 by different cell subtypes
pEpiTd19 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTd19 top program genes

Top genes of pEpiTd19 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTd19 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTd19
pEpiTd19 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0006955 immune response 3.66242830621905e-37 2311 123 79 0.642276422764228 0.0341843357853743
GO:BP GO:0034341 response to interferon-gamma 4.59972952971057e-34 196 135 34 0.251851851851852 0.173469387755102
GO:BP GO:0098542 defense response to other organism 8.21683957223981e-34 1218 135 62 0.459259259259259 0.0509031198686371
GO:BP GO:0043207 response to external biotic stimulus 2.66870388289058e-32 1594 135 67 0.496296296296296 0.0420326223337516
GO:BP GO:0051707 response to other organism 2.66870388289058e-32 1592 135 67 0.496296296296296 0.0420854271356784
GO:BP GO:0009607 response to biotic stimulus 7.60882665213554e-32 1626 135 67 0.496296296296296 0.0412054120541205
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 1.00654575752321e-31 174 41 22 0.536585365853659 0.126436781609195
GO:BP GO:0019882 antigen processing and presentation 1.47934913539614e-31 234 25 20 0.8 0.0854700854700855
GO:BP GO:0045087 innate immune response 2.00211745368197e-31 998 135 55 0.407407407407407 0.0551102204408818
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 2.00211745368197e-31 182 41 22 0.536585365853659 0.120879120879121
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 5.94992101703068e-31 192 25 19 0.76 0.0989583333333333
GO:BP GO:0002376 immune system process 1.79269526373085e-30 3278 132 86 0.651515151515151 0.026235509456986
GO:BP GO:0006952 defense response 1.99909695229012e-29 1818 138 68 0.492753623188406 0.0374037403740374
GO:BP GO:0019221 cytokine-mediated signaling pathway 1.99909695229012e-29 810 135 49 0.362962962962963 0.0604938271604938
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 2.09947467098898e-28 88 71 20 0.28169014084507 0.227272727272727
GO:BP GO:0071346 cellular response to interferon-gamma 2.45667966298665e-27 175 135 28 0.207407407407407 0.16
GO:BP GO:0034097 response to cytokine 4.30706493768819e-27 1226 135 55 0.407407407407407 0.0448613376835237
GO:BP GO:0050776 regulation of immune response 9.2070926694886e-27 996 111 46 0.414414414414414 0.0461847389558233
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 2.06654712141171e-26 2255 135 70 0.518518518518518 0.0310421286031042
GO:BP GO:0071345 cellular response to cytokine stimulus 2.12471954271528e-26 1132 71 39 0.549295774647887 0.034452296819788
GO:BP GO:0002682 regulation of immune system process 8.54491697663114e-25 1617 135 59 0.437037037037037 0.0364873222016079
GO:BP GO:0050778 positive regulation of immune response 3.79869049627796e-23 753 109 38 0.348623853211009 0.050464807436919
GO:BP GO:0002684 positive regulation of immune system process 7.67475245173168e-23 1065 109 43 0.394495412844037 0.0403755868544601
GO:BP GO:0019883 antigen processing and presentation of endogenous antigen 3.54718722025523e-22 26 36 11 0.305555555555556 0.423076923076923
GO:BP GO:0002483 antigen processing and presentation of endogenous peptide antigen 2.85614261322658e-21 19 36 10 0.277777777777778 0.526315789473684
GO:BP GO:0009605 response to external stimulus 4.23333159457611e-21 2944 135 72 0.533333333333333 0.0244565217391304
GO:BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 4.60513237479235e-20 75 40 13 0.325 0.173333333333333
GO:BP GO:0002250 adaptive immune response 7.15659969139101e-20 689 111 34 0.306306306306306 0.0493468795355588
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 1.05987201968638e-19 80 40 13 0.325 0.1625
GO:BP GO:0002252 immune effector process 1.23713278070741e-19 1309 84 38 0.452380952380952 0.0290297937356761
GO:BP GO:0060337 type I interferon signaling pathway 1.49194208053034e-19 95 79 16 0.20253164556962 0.168421052631579
GO:BP GO:0071357 cellular response to type I interferon 1.72868302429129e-19 96 79 16 0.20253164556962 0.166666666666667
GO:BP GO:0034340 response to type I interferon 3.98182299202798e-19 101 79 16 0.20253164556962 0.158415841584158
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 1.72831212410566e-18 99 40 13 0.325 0.131313131313131
GO:BP GO:0002831 regulation of response to biotic stimulus 3.41273513910309e-17 415 135 28 0.207407407407407 0.0674698795180723
GO:BP GO:0009615 response to virus 7.94621639473032e-17 364 131 26 0.198473282442748 0.0714285714285714
GO:BP GO:0045088 regulation of innate immune response 2.73052757553718e-16 309 69 19 0.27536231884058 0.0614886731391586
GO:BP GO:0048584 positive regulation of response to stimulus 1.25381626426259e-15 2344 111 51 0.459459459459459 0.0217576791808874
GO:BP GO:0006950 response to stress 4.13230413047097e-15 4170 132 75 0.568181818181818 0.0179856115107914
GO:BP GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent 4.63225296927719e-15 8 23 6 0.260869565217391 0.75
GO:BP GO:0071310 cellular response to organic substance 1.93096922454799e-14 2776 71 41 0.577464788732394 0.0147694524495677
GO:BP GO:0051607 defense response to virus 2.88301565029884e-14 267 131 21 0.16030534351145 0.0786516853932584
GO:BP GO:0140546 defense response to symbiont 2.88301565029884e-14 267 131 21 0.16030534351145 0.0786516853932584
GO:BP GO:0010033 response to organic substance 6.77595420818685e-14 3412 58 39 0.672413793103448 0.0114302461899179
GO:BP GO:0001916 positive regulation of T cell mediated cytotoxicity 8.96185049487488e-14 26 23 7 0.304347826086957 0.269230769230769
GO:BP GO:0050852 T cell receptor signaling pathway 1.10518776790813e-13 203 57 14 0.245614035087719 0.0689655172413793
GO:BP GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 2.33053206401463e-13 103 90 13 0.144444444444444 0.12621359223301
GO:BP GO:0002253 activation of immune response 4.19005139351252e-13 568 92 23 0.25 0.0404929577464789
GO:BP GO:0007166 cell surface receptor signaling pathway 6.88448018496279e-13 3210 107 54 0.504672897196262 0.0168224299065421
GO:BP GO:0001914 regulation of T cell mediated cytotoxicity 8.18808420865267e-13 35 23 7 0.304347826086957 0.2
GO:BP GO:0002697 regulation of immune effector process 9.99743716256107e-13 461 116 23 0.198275862068966 0.0498915401301518
GO:BP GO:0002683 negative regulation of immune system process 1.14680911333791e-12 420 91 20 0.21978021978022 0.0476190476190476
GO:BP GO:0001816 cytokine production 2.1914045731818e-12 844 57 21 0.368421052631579 0.0248815165876777
GO:BP GO:0070661 leukocyte proliferation 2.1914045731818e-12 325 135 21 0.155555555555556 0.0646153846153846
GO:BP GO:0031347 regulation of defense response 2.24194542000038e-12 704 135 29 0.214814814814815 0.0411931818181818
GO:BP GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 2.70725685495183e-12 96 90 12 0.133333333333333 0.125
GO:BP GO:0001913 T cell mediated cytotoxicity 2.86600845824797e-12 42 23 7 0.304347826086957 0.166666666666667
GO:BP GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 3.74638295517425e-12 13 36 6 0.166666666666667 0.461538461538462
GO:BP GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 4.25246767743089e-12 100 90 12 0.133333333333333 0.12
GO:BP GO:0070663 regulation of leukocyte proliferation 4.95645962357047e-12 251 123 18 0.146341463414634 0.0717131474103586
GO:BP GO:0046651 lymphocyte proliferation 6.05965982843096e-12 294 107 18 0.168224299065421 0.0612244897959184
GO:BP GO:0032943 mononuclear cell proliferation 7.04414215840667e-12 297 107 18 0.168224299065421 0.0606060606060606
GO:BP GO:0002711 positive regulation of T cell mediated immunity 7.04414215840667e-12 48 23 7 0.304347826086957 0.145833333333333
GO:BP GO:0032101 regulation of response to external stimulus 8.21646277879746e-12 1051 56 22 0.392857142857143 0.0209324452901998
GO:BP GO:0001817 regulation of cytokine production 9.25162936103185e-12 806 57 20 0.350877192982456 0.0248138957816377
GO:BP GO:0001912 positive regulation of leukocyte mediated cytotoxicity 1.05482743716545e-11 51 23 7 0.304347826086957 0.137254901960784
GO:BP GO:0050670 regulation of lymphocyte proliferation 1.39055821113867e-11 230 123 17 0.138211382113821 0.0739130434782609
GO:BP GO:0070887 cellular response to chemical stimulus 1.39814907088316e-11 3393 71 41 0.577464788732394 0.0120837017388742
GO:BP GO:0042221 response to chemical 1.45046909007063e-11 4781 58 42 0.724137931034483 0.00878477306002928
GO:BP GO:0032944 regulation of mononuclear cell proliferation 1.53306654440232e-11 232 123 17 0.138211382113821 0.0732758620689655
GO:BP GO:0016032 viral process 2.15849349839303e-11 942 27 15 0.555555555555556 0.0159235668789809
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 2.30033305358567e-11 323 92 17 0.184782608695652 0.0526315789473684
GO:BP GO:0031343 positive regulation of cell killing 2.79280361798265e-11 59 23 7 0.304347826086957 0.11864406779661
GO:BP GO:0042098 T cell proliferation 2.85363382126778e-11 205 123 16 0.130081300813008 0.0780487804878049
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 3.17524837064523e-11 363 111 19 0.171171171171171 0.0523415977961433
GO:BP GO:0044403 biological process involved in symbiotic interaction 4.85854831064754e-11 1001 27 15 0.555555555555556 0.014985014985015
GO:BP GO:0002501 peptide antigen assembly with MHC protein complex 8.41372120512441e-11 6 60 5 0.0833333333333333 0.833333333333333
GO:BP GO:0002503 peptide antigen assembly with MHC class II protein complex 1.13536634932776e-10 4 25 4 0.16 1
GO:BP GO:0001775 cell activation 1.13536634932776e-10 1495 43 21 0.488372093023256 0.0140468227424749
GO:BP GO:0002399 MHC class II protein complex assembly 1.13536634932776e-10 4 25 4 0.16 1
GO:BP GO:0045321 leukocyte activation 1.21315291547102e-10 1332 52 22 0.423076923076923 0.0165165165165165
GO:BP GO:0045824 negative regulation of innate immune response 1.21315291547102e-10 66 69 9 0.130434782608696 0.136363636363636
GO:BP GO:0001910 regulation of leukocyte mediated cytotoxicity 1.26549767274203e-10 74 23 7 0.304347826086957 0.0945945945945946
GO:BP GO:0002709 regulation of T cell mediated immunity 1.26549767274203e-10 74 23 7 0.304347826086957 0.0945945945945946
GO:BP GO:0002449 lymphocyte mediated immunity 1.94086140752232e-10 354 111 18 0.162162162162162 0.0508474576271186
GO:BP GO:0002699 positive regulation of immune effector process 2.56297453068392e-10 215 25 9 0.36 0.0418604651162791
GO:BP GO:0002396 MHC protein complex assembly 2.59972412768204e-10 7 60 5 0.0833333333333333 0.714285714285714
GO:BP GO:0050896 response to stimulus 3.70085053964737e-10 9407 132 106 0.803030303030303 0.0112682045285426
GO:BP GO:0048583 regulation of response to stimulus 5.02220830324565e-10 4278 58 38 0.655172413793103 0.00888265544647031
GO:BP GO:0042129 regulation of T cell proliferation 5.45397029006437e-10 176 123 14 0.113821138211382 0.0795454545454545
GO:BP GO:0031341 regulation of cell killing 6.02648031583948e-10 93 23 7 0.304347826086957 0.0752688172043011
GO:BP GO:0050777 negative regulation of immune response 6.02648031583948e-10 157 69 11 0.159420289855072 0.0700636942675159
GO:BP GO:0042110 T cell activation 6.41199312899383e-10 489 57 15 0.263157894736842 0.0306748466257669
GO:BP GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 7.36340390744094e-10 96 23 7 0.304347826086957 0.0729166666666667
GO:BP GO:0002456 T cell mediated immunity 8.44350649035056e-10 98 23 7 0.304347826086957 0.0714285714285714
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 8.61397960801188e-10 477 92 18 0.195652173913043 0.0377358490566038
GO:BP GO:0002757 immune response-activating signal transduction 8.61397960801188e-10 477 92 18 0.195652173913043 0.0377358490566038
GO:BP GO:0032103 positive regulation of response to external stimulus 8.61397960801188e-10 513 86 18 0.209302325581395 0.0350877192982456
GO:BP GO:0002819 regulation of adaptive immune response 9.69114724084812e-10 167 111 13 0.117117117117117 0.0778443113772455
GO:BP GO:0002821 positive regulation of adaptive immune response 9.9493196745134e-10 101 23 7 0.304347826086957 0.0693069306930693
GO:BP GO:0046649 lymphocyte activation 1.12606888721385e-09 771 111 24 0.216216216216216 0.0311284046692607
GO:BP GO:0002708 positive regulation of lymphocyte mediated immunity 1.20194962035185e-09 104 23 7 0.304347826086957 0.0673076923076923
GO:BP GO:0051249 regulation of lymphocyte activation 1.31770171653115e-09 518 123 21 0.170731707317073 0.0405405405405405
GO:BP GO:0070665 positive regulation of leukocyte proliferation 1.34052153531879e-09 155 123 13 0.105691056910569 0.0838709677419355
GO:BP GO:0001909 leukocyte mediated cytotoxicity 1.42989315081153e-09 107 23 7 0.304347826086957 0.0654205607476635
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 2.53662742321135e-09 512 92 18 0.195652173913043 0.03515625
GO:BP GO:0002764 immune response-regulating signaling pathway 2.76352663961724e-09 515 92 18 0.195652173913043 0.0349514563106796
GO:BP GO:0050865 regulation of cell activation 2.76600848012326e-09 655 135 24 0.177777777777778 0.0366412213740458
GO:BP GO:0050863 regulation of T cell activation 2.77193002982157e-09 337 30 10 0.333333333333333 0.029673590504451
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 2.827590785539e-09 338 30 10 0.333333333333333 0.029585798816568
GO:BP GO:0002703 regulation of leukocyte mediated immunity 2.88380828635302e-09 205 23 8 0.347826086956522 0.0390243902439024
GO:BP GO:0002705 positive regulation of leukocyte mediated immunity 3.40365311866266e-09 122 23 7 0.304347826086957 0.0573770491803279
GO:BP GO:0002832 negative regulation of response to biotic stimulus 4.04943384934485e-09 100 69 9 0.130434782608696 0.09
GO:BP GO:0002833 positive regulation of response to biotic stimulus 4.16539136159435e-09 250 85 13 0.152941176470588 0.052
GO:BP GO:0007165 signal transduction 5.41226972182121e-09 6309 69 50 0.72463768115942 0.00792518624187668
GO:BP GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib 5.45371488455434e-09 6 36 4 0.111111111111111 0.666666666666667
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 5.8296987472133e-09 141 123 12 0.0975609756097561 0.0851063829787234
GO:BP GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 6.1254262391403e-09 16 42 5 0.119047619047619 0.3125
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 6.22529996777478e-09 142 123 12 0.0975609756097561 0.0845070422535211
GO:BP GO:0007159 leukocyte cell-cell adhesion 7.14827587544798e-09 375 30 10 0.333333333333333 0.0266666666666667
GO:BP GO:0002716 negative regulation of natural killer cell mediated immunity 8.44813177183043e-09 17 42 5 0.119047619047619 0.294117647058824
GO:BP GO:0050870 positive regulation of T cell activation 9.60221267074635e-09 219 25 8 0.32 0.0365296803652968
GO:BP GO:0002468 dendritic cell antigen processing and presentation 9.62246021122425e-09 14 3 3 1 0.214285714285714
GO:BP GO:0045089 positive regulation of innate immune response 9.6697390691042e-09 216 85 12 0.141176470588235 0.0555555555555556
GO:BP GO:0002520 immune system development 9.73066495332377e-09 1020 42 16 0.380952380952381 0.0156862745098039
GO:BP GO:0001819 positive regulation of cytokine production 1.06068258909222e-08 452 53 13 0.245283018867925 0.0287610619469027
GO:BP GO:0002477 antigen processing and presentation of exogenous peptide antigen via MHC class Ib 1.16492382478404e-08 3 15 3 0.2 1
GO:BP GO:0002706 regulation of lymphocyte mediated immunity 1.34067092746636e-08 151 23 7 0.304347826086957 0.0463576158940397
GO:BP GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1.39341471914187e-08 152 23 7 0.304347826086957 0.0460526315789474
GO:BP GO:0080134 regulation of response to stress 1.61172949102452e-08 1443 56 21 0.375 0.0145530145530146
GO:BP GO:0051251 positive regulation of lymphocyte activation 1.87389259132035e-08 365 25 9 0.36 0.0246575342465753
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 1.89616892669688e-08 241 25 8 0.32 0.033195020746888
GO:BP GO:0002694 regulation of leukocyte activation 1.90158118006967e-08 610 111 20 0.18018018018018 0.0327868852459016
GO:BP GO:0001911 negative regulation of leukocyte mediated cytotoxicity 1.90158118006967e-08 20 42 5 0.119047619047619 0.25
GO:BP GO:0002718 regulation of cytokine production involved in immune response 2.01485261290545e-08 85 23 6 0.260869565217391 0.0705882352941176
GO:BP GO:0022407 regulation of cell-cell adhesion 3.31434536414629e-08 445 30 10 0.333333333333333 0.0224719101123595
GO:BP GO:0001906 cell killing 3.52082104394486e-08 175 23 7 0.304347826086957 0.04
GO:BP GO:0002367 cytokine production involved in immune response 3.64293235720454e-08 94 23 6 0.260869565217391 0.0638297872340425
GO:BP GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent 4.08403354218613e-08 3 23 3 0.130434782608696 1
GO:BP GO:0002704 negative regulation of leukocyte mediated immunity 4.08403354218613e-08 51 42 6 0.142857142857143 0.117647058823529
GO:BP GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway 4.08403354218613e-08 3 23 3 0.130434782608696 1
GO:BP GO:0031342 negative regulation of cell killing 4.88604660886703e-08 24 42 5 0.119047619047619 0.208333333333333
GO:BP GO:0002696 positive regulation of leukocyte activation 4.97253698253575e-08 412 25 9 0.36 0.0218446601941748
GO:BP GO:0002440 production of molecular mediator of immune response 5.73048010263686e-08 189 23 7 0.304347826086957 0.037037037037037
GO:BP GO:0022409 positive regulation of cell-cell adhesion 6.26108604854969e-08 284 25 8 0.32 0.028169014084507
GO:BP GO:0050867 positive regulation of cell activation 6.26108604854969e-08 424 25 9 0.36 0.0212264150943396
GO:BP GO:0002443 leukocyte mediated immunity 6.41891932694056e-08 877 47 15 0.319148936170213 0.0171037628278221
GO:BP GO:0034612 response to tumor necrosis factor 7.56276144514312e-08 331 135 16 0.118518518518519 0.0483383685800604
GO:BP GO:0023052 signaling 8.74454679663116e-08 6810 69 50 0.72463768115942 0.00734214390602056
GO:BP GO:0007154 cell communication 9.68717356822792e-08 6829 69 50 0.72463768115942 0.00732171621027969
GO:BP GO:0009617 response to bacterium 1.30601068772348e-07 743 135 23 0.17037037037037 0.0309555854643338
GO:BP GO:0048585 negative regulation of response to stimulus 1.32207343908919e-07 1733 58 22 0.379310344827586 0.0126947489901904
GO:BP GO:0002720 positive regulation of cytokine production involved in immune response 1.32369043788347e-07 54 23 5 0.217391304347826 0.0925925925925926
GO:BP GO:0070555 response to interleukin-1 1.65090031622434e-07 215 135 13 0.0962962962962963 0.0604651162790698
GO:BP GO:0071356 cellular response to tumor necrosis factor 1.90781845718078e-07 306 135 15 0.111111111111111 0.0490196078431373
GO:BP GO:0002475 antigen processing and presentation via MHC class Ib 1.91399665926554e-07 13 36 4 0.111111111111111 0.307692307692308
GO:BP GO:0031349 positive regulation of defense response 2.18245650623649e-07 362 69 12 0.173913043478261 0.0331491712707182
GO:BP GO:0030097 hemopoiesis 2.18245650623649e-07 928 42 14 0.333333333333333 0.0150862068965517
GO:BP GO:0046596 regulation of viral entry into host cell 2.25759007100174e-07 43 67 6 0.0895522388059701 0.13953488372093
GO:BP GO:1903900 regulation of viral life cycle 2.90807313939651e-07 153 131 11 0.083969465648855 0.0718954248366013
GO:BP GO:0050792 regulation of viral process 3.00766856821035e-07 192 131 12 0.0916030534351145 0.0625
GO:BP GO:0046634 regulation of alpha-beta T cell activation 3.14689012470484e-07 102 52 7 0.134615384615385 0.0686274509803922
GO:BP GO:0048534 hematopoietic or lymphoid organ development 3.51755782776239e-07 966 42 14 0.333333333333333 0.0144927536231884
GO:BP GO:0042127 regulation of cell population proliferation 3.52705083360832e-07 1774 55 21 0.381818181818182 0.0118376550169109
GO:BP GO:0008283 cell population proliferation 3.52705083360832e-07 2054 57 23 0.403508771929825 0.0111976630963973
GO:BP GO:0035456 response to interferon-beta 4.56533955502966e-07 30 53 5 0.0943396226415094 0.166666666666667
GO:BP GO:0002700 regulation of production of molecular mediator of immune response 4.60707587089492e-07 148 23 6 0.260869565217391 0.0405405405405405
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 4.83547523167463e-07 185 67 9 0.134328358208955 0.0486486486486487
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 5.09068717898725e-07 251 67 10 0.149253731343284 0.0398406374501992
GO:BP GO:0043903 regulation of biological process involved in symbiotic interaction 5.23778326736017e-07 203 131 12 0.0916030534351145 0.0591133004926108
GO:BP GO:0052372 modulation by symbiont of entry into host 5.30001554920287e-07 50 67 6 0.0895522388059701 0.12
GO:BP GO:0031348 negative regulation of defense response 5.53645093062841e-07 246 69 10 0.144927536231884 0.040650406504065
GO:BP GO:0002698 negative regulation of immune effector process 5.78693683900602e-07 125 47 7 0.148936170212766 0.056
GO:BP GO:0042270 protection from natural killer cell mediated cytotoxicity 6.52749281829599e-07 6 23 3 0.130434782608696 0.5
GO:BP GO:0042102 positive regulation of T cell proliferation 6.63505127462934e-07 104 123 9 0.0731707317073171 0.0865384615384615
GO:BP GO:0042269 regulation of natural killer cell mediated cytotoxicity 6.6762092961888e-07 41 42 5 0.119047619047619 0.121951219512195
GO:BP GO:0033209 tumor necrosis factor-mediated signaling pathway 7.76869522825617e-07 177 53 8 0.150943396226415 0.0451977401129944
GO:BP GO:0051716 cellular response to stimulus 7.7797363871794e-07 7781 69 52 0.753623188405797 0.00668294563680761
GO:BP GO:0030155 regulation of cell adhesion 8.27911141098362e-07 748 33 11 0.333333333333333 0.0147058823529412
GO:BP GO:0002707 negative regulation of lymphocyte mediated immunity 8.3585541857074e-07 43 42 5 0.119047619047619 0.116279069767442
GO:BP GO:0002366 leukocyte activation involved in immune response 8.46027592709853e-07 717 50 13 0.26 0.0181311018131102
GO:BP GO:0046640 regulation of alpha-beta T cell proliferation 8.51705291688879e-07 35 52 5 0.0961538461538462 0.142857142857143
GO:BP GO:0002263 cell activation involved in immune response 8.93184722977302e-07 721 50 13 0.26 0.0180305131761442
GO:BP GO:0002715 regulation of natural killer cell mediated immunity 1.03454737748585e-06 45 42 5 0.119047619047619 0.111111111111111
GO:BP GO:0032609 interferon-gamma production 1.21047559767654e-06 115 57 7 0.12280701754386 0.0608695652173913
GO:BP GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib 1.23152331216575e-06 5 36 3 0.0833333333333333 0.6
GO:BP GO:0046633 alpha-beta T cell proliferation 1.27376234110278e-06 38 52 5 0.0961538461538462 0.131578947368421
GO:BP GO:0030593 neutrophil chemotaxis 1.27495154167182e-06 103 135 9 0.0666666666666667 0.087378640776699
GO:BP GO:0045785 positive regulation of cell adhesion 1.36820112253336e-06 437 25 8 0.32 0.0183066361556064
GO:BP GO:0051239 regulation of multicellular organismal process 1.71842833998112e-06 2861 57 26 0.456140350877193 0.00908773156239077
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 1.80824381425943e-06 291 67 10 0.149253731343284 0.0343642611683849
GO:BP GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation 1.9080663188719e-06 5 42 3 0.0714285714285714 0.6
GO:BP GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation 1.9080663188719e-06 5 42 3 0.0714285714285714 0.6
GO:BP GO:0052548 regulation of endopeptidase activity 1.91372242459896e-06 437 58 11 0.189655172413793 0.0251716247139588
GO:BP GO:0002230 positive regulation of defense response to virus by host 1.96586906395594e-06 33 131 6 0.0458015267175573 0.181818181818182
GO:BP GO:0045582 positive regulation of T cell differentiation 1.99502030174758e-06 91 3 3 1 0.032967032967033
GO:BP GO:0071347 cellular response to interleukin-1 2.2575841318806e-06 185 135 11 0.0814814814814815 0.0594594594594595
GO:BP GO:0002702 positive regulation of production of molecular mediator of immune response 2.32038116555313e-06 100 23 5 0.217391304347826 0.05
GO:BP GO:0045621 positive regulation of lymphocyte differentiation 2.94586797878038e-06 104 3 3 1 0.0288461538461538
GO:BP GO:0035740 CD8-positive, alpha-beta T cell proliferation 3.25995519374363e-06 8 29 3 0.103448275862069 0.375
GO:BP GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation 3.25995519374363e-06 8 29 3 0.103448275862069 0.375
GO:BP GO:0052547 regulation of peptidase activity 3.57906396236891e-06 467 58 11 0.189655172413793 0.0235546038543897
GO:BP GO:0002286 T cell activation involved in immune response 3.61508428243224e-06 112 3 3 1 0.0267857142857143
GO:BP GO:0006959 humoral immune response 4.03668871659665e-06 384 86 12 0.13953488372093 0.03125
GO:BP GO:0019058 viral life cycle 4.27781254022813e-06 353 131 14 0.106870229007634 0.0396600566572238
GO:BP GO:0006521 regulation of cellular amino acid metabolic process 4.33562876206046e-06 64 40 5 0.125 0.078125
GO:BP GO:0071677 positive regulation of mononuclear cell migration 4.33562876206046e-06 65 123 7 0.0569105691056911 0.107692307692308
GO:BP GO:0046631 alpha-beta T cell activation 4.35323823906304e-06 155 52 7 0.134615384615385 0.0451612903225806
GO:BP GO:0048518 positive regulation of biological process 4.47888260616763e-06 6363 55 38 0.690909090909091 0.00597202577400597
GO:BP GO:0051250 negative regulation of lymphocyte activation 4.50491994569098e-06 156 52 7 0.134615384615385 0.0448717948717949
GO:BP GO:0042267 natural killer cell mediated cytotoxicity 4.64827263622904e-06 62 42 5 0.119047619047619 0.0806451612903226
GO:BP GO:1903706 regulation of hemopoiesis 5.4564333693207e-06 424 8 5 0.625 0.0117924528301887
GO:BP GO:1990266 neutrophil migration 5.58416333956063e-06 124 135 9 0.0666666666666667 0.0725806451612903
GO:BP GO:0051241 negative regulation of multicellular organismal process 5.6298616538862e-06 1160 135 26 0.192592592592593 0.0224137931034483
GO:BP GO:1903131 mononuclear cell differentiation 5.76763433400737e-06 430 8 5 0.625 0.0116279069767442
GO:BP GO:0002228 natural killer cell mediated immunity 5.76763433400737e-06 65 42 5 0.119047619047619 0.0769230769230769
GO:BP GO:0048525 negative regulation of viral process 5.85914277648712e-06 94 131 8 0.0610687022900763 0.0851063829787234
GO:BP GO:0071621 granulocyte chemotaxis 6.25410677725354e-06 126 135 9 0.0666666666666667 0.0714285714285714
GO:BP GO:0046635 positive regulation of alpha-beta T cell activation 6.62947937031862e-06 67 42 5 0.119047619047619 0.0746268656716418
GO:BP GO:0002584 negative regulation of antigen processing and presentation of peptide antigen 6.85793828388705e-06 4 90 3 0.0333333333333333 0.75
GO:BP GO:0050866 negative regulation of cell activation 7.51316729213947e-06 211 135 11 0.0814814814814815 0.0521327014218009
GO:BP GO:0002507 tolerance induction 8.13483797402989e-06 29 42 4 0.0952380952380952 0.137931034482759
GO:BP GO:0045580 regulation of T cell differentiation 8.25547290809659e-06 152 3 3 1 0.0197368421052632
GO:BP GO:0030217 T cell differentiation 8.62860955587552e-06 260 6 4 0.666666666666667 0.0153846153846154
GO:BP GO:0050691 regulation of defense response to virus by host 8.78091746168267e-06 43 131 6 0.0458015267175573 0.13953488372093
GO:BP GO:1902036 regulation of hematopoietic stem cell differentiation 8.78091746168267e-06 75 40 5 0.125 0.0666666666666667
GO:BP GO:1902107 positive regulation of leukocyte differentiation 8.86760961100292e-06 157 3 3 1 0.0191082802547771
GO:BP GO:1903708 positive regulation of hemopoiesis 8.86760961100292e-06 157 3 3 1 0.0191082802547771
GO:BP GO:0140289 protein mono-ADP-ribosylation 8.86760961100292e-06 12 111 4 0.036036036036036 0.333333333333333
GO:BP GO:0038061 NIK/NF-kappaB signaling 9.8539397020342e-06 194 69 8 0.115942028985507 0.0412371134020619
GO:BP GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 1.04158057467962e-05 78 40 5 0.125 0.0641025641025641
GO:BP GO:0000209 protein polyubiquitination 1.15555918059809e-05 342 127 13 0.102362204724409 0.0380116959064327
GO:BP GO:0002687 positive regulation of leukocyte migration 1.17885419694377e-05 137 135 9 0.0666666666666667 0.0656934306569343
GO:BP GO:0046718 viral entry into host cell 1.18756611463432e-05 141 67 7 0.104477611940299 0.049645390070922
GO:BP GO:0045619 regulation of lymphocyte differentiation 1.30042778122281e-05 180 3 3 1 0.0166666666666667
GO:BP GO:0033238 regulation of cellular amine metabolic process 1.30968946537167e-05 82 40 5 0.125 0.0609756097560976
GO:BP GO:0098609 cell-cell adhesion 1.32606832554493e-05 894 30 10 0.333333333333333 0.0111856823266219
GO:BP GO:0002695 negative regulation of leukocyte activation 1.38531066617705e-05 188 52 7 0.134615384615385 0.0372340425531915
GO:BP GO:0030595 leukocyte chemotaxis 1.42012208653026e-05 227 135 11 0.0814814814814815 0.0484581497797357
GO:BP GO:0002285 lymphocyte activation involved in immune response 1.4932955516901e-05 190 3 3 1 0.0157894736842105
GO:BP GO:0031145 anaphase-promoting complex-dependent catabolic process 1.5286541513718e-05 85 40 5 0.125 0.0588235294117647
GO:BP GO:0016045 detection of bacterium 1.55443389949197e-05 17 23 3 0.130434782608696 0.176470588235294
GO:BP GO:0045589 regulation of regulatory T cell differentiation 1.59148053421637e-05 35 42 4 0.0952380952380952 0.114285714285714
GO:BP GO:0010628 positive regulation of gene expression 1.59293931831087e-05 1160 30 11 0.366666666666667 0.00948275862068966
GO:BP GO:0002521 leukocyte differentiation 1.67429901358629e-05 550 8 5 0.625 0.00909090909090909
GO:BP GO:0050868 negative regulation of T cell activation 1.73295245081451e-05 123 52 6 0.115384615384615 0.0487804878048781
GO:BP GO:0044106 cellular amine metabolic process 1.8140653924847e-05 163 40 6 0.15 0.0368098159509202
GO:BP GO:1901532 regulation of hematopoietic progenitor cell differentiation 1.83256326600335e-05 89 40 5 0.125 0.0561797752808989
GO:BP GO:0060218 hematopoietic stem cell differentiation 1.83256326600335e-05 89 40 5 0.125 0.0561797752808989
GO:BP GO:0051240 positive regulation of multicellular organismal process 1.88773867958531e-05 1455 30 12 0.4 0.00824742268041237
GO:BP GO:0044409 entry into host 1.96610476038679e-05 154 67 7 0.104477611940299 0.0454545454545455
GO:BP GO:0098543 detection of other organism 2.10171995512431e-05 19 23 3 0.130434782608696 0.157894736842105
GO:BP GO:0009308 amine metabolic process 2.10561593873676e-05 168 40 6 0.15 0.0357142857142857
GO:BP GO:0045066 regulatory T cell differentiation 2.11801566912996e-05 38 42 4 0.0952380952380952 0.105263157894737
GO:BP GO:0090713 immunological memory process 2.11801566912996e-05 17 97 4 0.0412371134020619 0.235294117647059
GO:BP GO:0042180 cellular ketone metabolic process 2.29629031591355e-05 271 40 7 0.175 0.025830258302583
GO:BP GO:0097530 granulocyte migration 2.36005385686154e-05 151 135 9 0.0666666666666667 0.0596026490066225
GO:BP GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 2.43892544612738e-05 95 40 5 0.125 0.0526315789473684
GO:BP GO:0002583 regulation of antigen processing and presentation of peptide antigen 2.80951096291224e-05 6 90 3 0.0333333333333333 0.5
GO:BP GO:0010565 regulation of cellular ketone metabolic process 2.82465189927981e-05 194 21 5 0.238095238095238 0.0257731958762887
GO:BP GO:0006471 protein ADP-ribosylation 3.02634922515928e-05 36 111 5 0.045045045045045 0.138888888888889
GO:BP GO:0045595 regulation of cell differentiation 3.11658932852796e-05 1679 42 15 0.357142857142857 0.00893388921977368
GO:BP GO:0030098 lymphocyte differentiation 3.11658932852796e-05 376 6 4 0.666666666666667 0.0106382978723404
GO:BP GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 3.37847110166763e-05 102 40 5 0.125 0.0490196078431373
GO:BP GO:2001185 regulation of CD8-positive, alpha-beta T cell activation 3.4564015456367e-05 18 29 3 0.103448275862069 0.166666666666667
GO:BP GO:0032102 negative regulation of response to external stimulus 3.47934093480413e-05 406 69 10 0.144927536231884 0.0246305418719212
GO:BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 3.6574509995334e-05 142 52 6 0.115384615384615 0.0422535211267606
GO:BP GO:0002577 regulation of antigen processing and presentation 3.68932916776146e-05 21 90 4 0.0444444444444444 0.19047619047619
GO:BP GO:0002690 positive regulation of leukocyte chemotaxis 3.76443551564369e-05 93 123 7 0.0569105691056911 0.0752688172043011
GO:BP GO:0070498 interleukin-1-mediated signaling pathway 3.81456793369194e-05 105 40 5 0.125 0.0476190476190476
GO:BP GO:0010468 regulation of gene expression 3.91735784959518e-05 5196 24 18 0.75 0.00346420323325635
GO:BP GO:0098581 detection of external biotic stimulus 4.04741635565073e-05 24 23 3 0.130434782608696 0.125
GO:BP GO:0002218 activation of innate immune response 4.349657447554e-05 144 53 6 0.113207547169811 0.0416666666666667
GO:BP GO:0070098 chemokine-mediated signaling pathway 4.38963479133252e-05 87 135 7 0.0518518518518519 0.0804597701149425
GO:BP GO:1902105 regulation of leukocyte differentiation 4.47932924724958e-05 288 3 3 1 0.0104166666666667
GO:BP GO:0052126 movement in host environment 4.49540811949961e-05 177 67 7 0.104477611940299 0.0395480225988701
GO:BP GO:0060071 Wnt signaling pathway, planar cell polarity pathway 4.67962088177041e-05 110 40 5 0.125 0.0454545454545455
GO:BP GO:0048522 positive regulation of cellular process 4.76774480541676e-05 5757 55 34 0.618181818181818 0.00590585374326906
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 4.84202856409392e-05 111 40 5 0.125 0.045045045045045
GO:BP GO:0002223 stimulatory C-type lectin receptor signaling pathway 5.04280059000813e-05 112 40 5 0.125 0.0446428571428571
GO:BP GO:1902750 negative regulation of cell cycle G2/M phase transition 5.24978817396877e-05 113 40 5 0.125 0.0442477876106195
GO:BP GO:0090175 regulation of establishment of planar polarity 5.46311686058453e-05 114 40 5 0.125 0.043859649122807
GO:BP GO:2000736 regulation of stem cell differentiation 5.66371423712639e-05 115 40 5 0.125 0.0434782608695652
GO:BP GO:0002220 innate immune response activating cell surface receptor signaling pathway 5.66371423712639e-05 115 40 5 0.125 0.0434782608695652
GO:BP GO:0032649 regulation of interferon-gamma production 5.81009693930305e-05 110 42 5 0.119047619047619 0.0454545454545455
GO:BP GO:0002758 innate immune response-activating signal transduction 5.86964531568556e-05 116 40 5 0.125 0.0431034482758621
GO:BP GO:0016064 immunoglobulin mediated immune response 5.92899915733769e-05 223 132 10 0.0757575757575758 0.0448430493273543
GO:BP GO:2000403 positive regulation of lymphocyte migration 5.98910444317546e-05 38 123 5 0.040650406504065 0.131578947368421
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 6.06079418182168e-05 117 40 5 0.125 0.0427350427350427
GO:BP GO:0048519 negative regulation of biological process 6.5921676084277e-05 5757 69 40 0.579710144927536 0.00694806322737537
GO:BP GO:0019724 B cell mediated immunity 6.5921676084277e-05 226 132 10 0.0757575757575758 0.0442477876106195
GO:BP GO:0097529 myeloid leukocyte migration 6.5921676084277e-05 221 135 10 0.0740740740740741 0.0452488687782805
GO:BP GO:0050798 activated T cell proliferation 6.62841950300816e-05 49 97 5 0.0515463917525773 0.102040816326531
GO:BP GO:0032020 ISG15-protein conjugation 6.97633034524726e-05 6 127 3 0.0236220472440945 0.5
GO:BP GO:0006508 proteolysis 7.45873179895327e-05 1836 73 21 0.287671232876712 0.011437908496732
GO:BP GO:0048247 lymphocyte chemotaxis 7.68091862691338e-05 63 135 6 0.0444444444444444 0.0952380952380952
GO:BP GO:1990868 response to chemokine 8.34083215009384e-05 97 135 7 0.0518518518518519 0.0721649484536082
GO:BP GO:1990869 cellular response to chemokine 8.34083215009384e-05 97 135 7 0.0518518518518519 0.0721649484536082
GO:BP GO:0006520 cellular amino acid metabolic process 8.90880267219259e-05 341 40 7 0.175 0.0205278592375367
GO:BP GO:0048523 negative regulation of cellular process 9.08906068635479e-05 5139 69 37 0.536231884057971 0.00719984432769021
GO:BP GO:0001736 establishment of planar polarity 9.65833470921914e-05 130 40 5 0.125 0.0384615384615385
GO:BP GO:0007164 establishment of tissue polarity 9.65833470921914e-05 130 40 5 0.125 0.0384615384615385
GO:BP GO:0002724 regulation of T cell cytokine production 9.66789167142136e-05 33 23 3 0.130434782608696 0.0909090909090909
GO:BP GO:0002578 negative regulation of antigen processing and presentation 9.8743199784415e-05 9 90 3 0.0333333333333333 0.333333333333333
GO:BP GO:0036037 CD8-positive, alpha-beta T cell activation 0.000105830599204929 27 29 3 0.103448275862069 0.111111111111111
GO:BP GO:0032615 interleukin-12 production 0.000110788873077138 60 42 4 0.0952380952380952 0.0666666666666667
GO:BP GO:0032655 regulation of interleukin-12 production 0.000110788873077138 60 42 4 0.0952380952380952 0.0666666666666667
GO:BP GO:0002274 myeloid leukocyte activation 0.00011557364986198 667 50 10 0.2 0.0149925037481259
GO:BP GO:0071675 regulation of mononuclear cell migration 0.000118578923210878 113 123 7 0.0569105691056911 0.0619469026548673
GO:BP GO:0070212 protein poly-ADP-ribosylation 0.00012152300886302 8 111 3 0.027027027027027 0.375
GO:BP GO:0009595 detection of biotic stimulus 0.000121972541933967 36 23 3 0.130434782608696 0.0833333333333333
GO:BP GO:0002369 T cell cytokine production 0.000121972541933967 36 23 3 0.130434782608696 0.0833333333333333
GO:BP GO:0050688 regulation of defense response to virus 0.000121972541933967 71 131 6 0.0458015267175573 0.0845070422535211
GO:BP GO:0008284 positive regulation of cell population proliferation 0.000126620611152936 982 43 11 0.255813953488372 0.0112016293279022
GO:BP GO:0042832 defense response to protozoan 0.000128311445912043 25 107 4 0.0373831775700935 0.16
GO:BP GO:0071674 mononuclear cell migration 0.00012857463136009 191 135 9 0.0666666666666667 0.0471204188481675
GO:BP GO:0046641 positive regulation of alpha-beta T cell proliferation 0.000143950136703481 21 42 3 0.0714285714285714 0.142857142857143
GO:BP GO:0001562 response to protozoan 0.00014915601789802 26 107 4 0.0373831775700935 0.153846153846154
GO:BP GO:0032729 positive regulation of interferon-gamma production 0.000153976129072188 66 42 4 0.0952380952380952 0.0606060606060606
GO:BP GO:0010499 proteasomal ubiquitin-independent protein catabolic process 0.000161808639098069 23 40 3 0.075 0.130434782608696
GO:BP GO:0051701 biological process involved in interaction with host 0.000161808639098069 221 67 7 0.104477611940299 0.0316742081447964
GO:BP GO:0002688 regulation of leukocyte chemotaxis 0.000166393838052238 120 123 7 0.0569105691056911 0.0583333333333333
GO:BP GO:0022408 negative regulation of cell-cell adhesion 0.00017664432001337 194 52 6 0.115384615384615 0.0309278350515464
GO:BP GO:0010950 positive regulation of endopeptidase activity 0.000178373068776536 187 54 6 0.111111111111111 0.0320855614973262
GO:BP GO:0035567 non-canonical Wnt signaling pathway 0.000181751537759092 151 40 5 0.125 0.033112582781457
GO:BP GO:0090263 positive regulation of canonical Wnt signaling pathway 0.000181751537759092 151 40 5 0.125 0.033112582781457
GO:BP GO:0001738 morphogenesis of a polarized epithelium 0.000187091772000612 152 40 5 0.125 0.0328947368421053
GO:BP GO:0009967 positive regulation of signal transduction 0.000191533144844148 1598 69 18 0.260869565217391 0.0112640801001252
GO:BP GO:0060326 cell chemotaxis 0.000193311715843802 310 135 11 0.0814814814814815 0.0354838709677419
GO:BP GO:0030162 regulation of proteolysis 0.00020501305262086 752 58 11 0.189655172413793 0.0146276595744681
GO:BP GO:0010467 gene expression 0.000205716441098314 6179 57 35 0.614035087719298 0.00566434698171225
GO:BP GO:0010647 positive regulation of cell communication 0.000215170099083443 1777 69 19 0.27536231884058 0.0106921778277997
GO:BP GO:0007162 negative regulation of cell adhesion 0.000219155150987266 304 52 7 0.134615384615385 0.0230263157894737
GO:BP GO:0001818 negative regulation of cytokine production 0.000219765236797544 381 42 7 0.166666666666667 0.0183727034120735
GO:BP GO:0023056 positive regulation of signaling 0.000221350350558594 1782 69 19 0.27536231884058 0.010662177328844
GO:BP GO:0006954 inflammatory response 0.000222483148324952 794 135 18 0.133333333333333 0.0226700251889169
GO:BP GO:0042130 negative regulation of T cell proliferation 0.000236988776977601 70 91 5 0.0549450549450549 0.0714285714285714
GO:BP GO:1901623 regulation of lymphocyte chemotaxis 0.000237819664173812 26 123 4 0.032520325203252 0.153846153846154
GO:BP GO:0072676 lymphocyte migration 0.000241083802144658 117 135 7 0.0518518518518519 0.0598290598290598
GO:BP GO:0010629 negative regulation of gene expression 0.000243827157465343 1460 44 13 0.295454545454545 0.0089041095890411
GO:BP GO:0050830 defense response to Gram-positive bacterium 0.000246078720172426 101 106 6 0.0566037735849057 0.0594059405940594
GO:BP GO:0002685 regulation of leukocyte migration 0.0002555373946987 211 135 9 0.0666666666666667 0.042654028436019
GO:BP GO:0009435 NAD biosynthetic process 0.000263074313880918 29 113 4 0.0353982300884956 0.137931034482759
GO:BP GO:0035458 cellular response to interferon-beta 0.000263074313880918 21 53 3 0.0566037735849057 0.142857142857143
GO:BP GO:0038095 Fc-epsilon receptor signaling pathway 0.00027441453874498 167 40 5 0.125 0.029940119760479
GO:BP GO:0043299 leukocyte degranulation 0.000275381940778412 535 43 8 0.186046511627907 0.0149532710280374
GO:BP GO:0010952 positive regulation of peptidase activity 0.000275381940778412 205 54 6 0.111111111111111 0.0292682926829268
GO:BP GO:0045071 negative regulation of viral genome replication 0.000275630159852389 54 123 5 0.040650406504065 0.0925925925925926
GO:BP GO:0051603 proteolysis involved in cellular protein catabolic process 0.000308542689763666 750 41 9 0.219512195121951 0.012
GO:BP GO:0010818 T cell chemotaxis 0.00031021483092498 28 123 4 0.032520325203252 0.142857142857143
GO:BP GO:0002244 hematopoietic progenitor cell differentiation 0.00031021483092498 172 40 5 0.125 0.0290697674418605
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.00033269100435466 551 43 8 0.186046511627907 0.014519056261343
GO:BP GO:0007155 cell adhesion 0.00033833261650464 1492 33 11 0.333333333333333 0.00737265415549598
GO:BP GO:0051259 protein complex oligomerization 0.000345871511943052 234 6 3 0.5 0.0128205128205128
GO:BP GO:0022610 biological adhesion 0.000347871151041293 1499 33 11 0.333333333333333 0.00733822548365577
GO:BP GO:0050793 regulation of developmental process 0.000347871151041293 2605 55 20 0.363636363636364 0.00767754318618042
GO:BP GO:0019359 nicotinamide nucleotide biosynthetic process 0.000369662442624517 32 113 4 0.0353982300884956 0.125
GO:BP GO:0019363 pyridine nucleotide biosynthetic process 0.000369662442624517 32 113 4 0.0353982300884956 0.125
GO:BP GO:0050921 positive regulation of chemotaxis 0.000406989392344695 141 123 7 0.0569105691056911 0.049645390070922
GO:BP GO:0032673 regulation of interleukin-4 production 0.000406989392344695 31 42 3 0.0714285714285714 0.0967741935483871
GO:BP GO:2000027 regulation of animal organ morphogenesis 0.000409580984975881 184 40 5 0.125 0.0271739130434783
GO:BP GO:0030177 positive regulation of Wnt signaling pathway 0.000409580984975881 184 40 5 0.125 0.0271739130434783
GO:BP GO:0019730 antimicrobial humoral response 0.000432474107854476 145 121 7 0.0578512396694215 0.0482758620689655
GO:BP GO:0090090 negative regulation of canonical Wnt signaling pathway 0.000437955386462327 187 40 5 0.125 0.0267379679144385
GO:BP GO:0032633 interleukin-4 production 0.000439492949725405 32 42 3 0.0714285714285714 0.09375
GO:BP GO:2000406 positive regulation of T cell migration 0.000440505764106314 31 123 4 0.032520325203252 0.129032258064516
GO:BP GO:0045637 regulation of myeloid cell differentiation 0.000464780608272861 263 6 3 0.5 0.0114068441064639
GO:BP GO:0043488 regulation of mRNA stability 0.000477126543271693 191 40 5 0.125 0.0261780104712042
GO:BP GO:0072525 pyridine-containing compound biosynthetic process 0.000508552217979133 35 113 4 0.0353982300884956 0.114285714285714
GO:BP GO:0046496 nicotinamide nucleotide metabolic process 0.000508552217979133 35 113 4 0.0353982300884956 0.114285714285714
GO:BP GO:0019362 pyridine nucleotide metabolic process 0.000508552217979133 35 113 4 0.0353982300884956 0.114285714285714
GO:BP GO:0046007 negative regulation of activated T cell proliferation 0.000512058423679196 16 91 3 0.032967032967033 0.1875
GO:BP GO:0044257 cellular protein catabolic process 0.000528571382597081 813 41 9 0.219512195121951 0.011070110701107
GO:BP GO:2000401 regulation of lymphocyte migration 0.000530772694191595 63 123 5 0.040650406504065 0.0793650793650794
GO:BP GO:0050672 negative regulation of lymphocyte proliferation 0.000530988085708498 85 91 5 0.0549450549450549 0.0588235294117647
GO:BP GO:0032945 negative regulation of mononuclear cell proliferation 0.000560197152947413 86 91 5 0.0549450549450549 0.0581395348837209
GO:BP GO:0006511 ubiquitin-dependent protein catabolic process 0.000573399336623465 655 21 6 0.285714285714286 0.00916030534351145
GO:BP GO:0043487 regulation of RNA stability 0.000582278928552782 201 21 4 0.19047619047619 0.0199004975124378
GO:BP GO:0009968 negative regulation of signal transduction 0.000587184127644065 1364 58 14 0.241379310344828 0.0102639296187683
GO:BP GO:0019941 modification-dependent protein catabolic process 0.000602450561375841 662 21 6 0.285714285714286 0.00906344410876133
GO:BP GO:0016567 protein ubiquitination 0.00063880664840897 892 23 7 0.304347826086957 0.007847533632287
GO:BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 0.000646441326584994 207 21 4 0.19047619047619 0.0193236714975845
GO:BP GO:0043632 modification-dependent macromolecule catabolic process 0.00065536363806301 673 21 6 0.285714285714286 0.00891530460624071
GO:BP GO:0072678 T cell migration 0.000693576264478385 67 123 5 0.040650406504065 0.0746268656716418
GO:BP GO:0071456 cellular response to hypoxia 0.000704034145009699 212 21 4 0.19047619047619 0.0188679245283019
GO:BP GO:0061013 regulation of mRNA catabolic process 0.000715293038380329 213 21 4 0.19047619047619 0.0187793427230047
GO:BP GO:0046006 regulation of activated T cell proliferation 0.000728484844765351 45 97 4 0.0412371134020619 0.0888888888888889
GO:BP GO:0032735 positive regulation of interleukin-12 production 0.00073241326807009 41 107 4 0.0373831775700935 0.0975609756097561
GO:BP GO:0030890 positive regulation of B cell proliferation 0.00073241326807009 41 107 4 0.0373831775700935 0.0975609756097561
GO:BP GO:0070664 negative regulation of leukocyte proliferation 0.000740509408658349 92 91 5 0.0549450549450549 0.0543478260869565
GO:BP GO:0030178 negative regulation of Wnt signaling pathway 0.000769828407925241 218 21 4 0.19047619047619 0.018348623853211
GO:BP GO:0070234 positive regulation of T cell apoptotic process 0.000777756014897941 14 123 3 0.024390243902439 0.214285714285714
GO:BP GO:0036294 cellular response to decreased oxygen levels 0.000820170167271053 222 21 4 0.19047619047619 0.018018018018018
GO:BP GO:1903901 negative regulation of viral life cycle 0.000829913514955734 26 66 3 0.0454545454545455 0.115384615384615
GO:BP GO:1902749 regulation of cell cycle G2/M phase transition 0.000830728214396488 223 21 4 0.19047619047619 0.0179372197309417
GO:BP GO:0045597 positive regulation of cell differentiation 0.000831731206045017 879 3 3 1 0.00341296928327645
GO:BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 0.000832723201190672 434 21 5 0.238095238095238 0.0115207373271889
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.00083608173946721 547 50 8 0.16 0.0146252285191956
GO:BP GO:2000116 regulation of cysteine-type endopeptidase activity 0.000836507625418334 240 58 6 0.103448275862069 0.025
GO:BP GO:0072524 pyridine-containing compound metabolic process 0.000878533141685149 41 113 4 0.0353982300884956 0.0975609756097561
GO:BP GO:0060334 regulation of interferon-gamma-mediated signaling pathway 0.000888962074645878 26 68 3 0.0441176470588235 0.115384615384615
GO:BP GO:0060330 regulation of response to interferon-gamma 0.000888962074645878 26 68 3 0.0441176470588235 0.115384615384615
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.000915635626318363 1042 43 10 0.232558139534884 0.00959692898272553
GO:BP GO:0062012 regulation of small molecule metabolic process 0.0009394825784959 447 21 5 0.238095238095238 0.0111856823266219
GO:BP GO:0043687 post-translational protein modification 0.000943068655201285 362 40 6 0.15 0.0165745856353591
GO:BP GO:0035455 response to interferon-alpha 0.000946018131076426 23 79 3 0.0379746835443038 0.130434782608696
GO:BP GO:0055065 metal ion homeostasis 0.000968044321503979 667 135 15 0.111111111111111 0.0224887556221889
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.000969140986236477 6603 24 18 0.75 0.00272603362108133
GO:BP GO:0006875 cellular metal ion homeostasis 0.000983838454769414 593 135 14 0.103703703703704 0.0236087689713322
GO:BP GO:0002548 monocyte chemotaxis 0.00100259940275145 67 135 5 0.037037037037037 0.0746268656716418
GO:BP GO:0032446 protein modification by small protein conjugation 0.00101814303266059 973 23 7 0.304347826086957 0.00719424460431655
GO:BP GO:0038093 Fc receptor signaling pathway 0.00102112247693493 238 21 4 0.19047619047619 0.0168067226890756
GO:BP GO:2000026 regulation of multicellular organismal development 0.00102920277192649 1447 8 5 0.625 0.00345542501727713
GO:BP GO:0071453 cellular response to oxygen levels 0.00104994960064165 240 21 4 0.19047619047619 0.0166666666666667
GO:BP GO:0008285 negative regulation of cell population proliferation 0.0010734122061088 790 91 13 0.142857142857143 0.0164556962025316
GO:BP GO:0045055 regulated exocytosis 0.00110548631451928 785 47 9 0.191489361702128 0.0114649681528662
GO:BP GO:0010648 negative regulation of cell communication 0.00114933642190028 1468 58 14 0.241379310344828 0.00953678474114441
GO:BP GO:0023057 negative regulation of signaling 0.00117181884683935 1471 58 14 0.241379310344828 0.00951733514615908
GO:BP GO:0046903 secretion 0.00119298827149154 1501 8 5 0.625 0.0033311125916056
GO:BP GO:0097028 dendritic cell differentiation 0.00126399469783538 48 42 3 0.0714285714285714 0.0625
GO:BP GO:0010819 regulation of T cell chemotaxis 0.0013029719436909 17 123 3 0.024390243902439 0.176470588235294
GO:BP GO:0070230 positive regulation of lymphocyte apoptotic process 0.0013029719436909 17 123 3 0.024390243902439 0.176470588235294
GO:BP GO:0048863 stem cell differentiation 0.00133375581649448 258 21 4 0.19047619047619 0.0155038759689922
GO:BP GO:0002009 morphogenesis of an epithelium 0.00133605110989485 560 40 7 0.175 0.0125
GO:BP GO:1901565 organonitrogen compound catabolic process 0.00133994381302932 1358 56 13 0.232142857142857 0.00957290132547865
GO:BP GO:0010498 proteasomal protein catabolic process 0.0013572587237326 491 21 5 0.238095238095238 0.010183299389002
GO:BP GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 0.0013911734015358 81 121 5 0.0413223140495868 0.0617283950617284
GO:BP GO:1901991 negative regulation of mitotic cell cycle phase transition 0.00139718479621641 262 21 4 0.19047619047619 0.0152671755725191
GO:BP GO:0000086 G2/M transition of mitotic cell cycle 0.00145636761145655 265 21 4 0.19047619047619 0.0150943396226415
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.00146390911891976 3241 69 25 0.36231884057971 0.00771366862079605
GO:BP GO:2000404 regulation of T cell migration 0.00146677514528348 44 123 4 0.032520325203252 0.0909090909090909
GO:BP GO:0000165 MAPK cascade 0.00156322560049187 935 42 9 0.214285714285714 0.00962566844919786
GO:BP GO:0030099 myeloid cell differentiation 0.00161964175155539 428 6 3 0.5 0.00700934579439252
GO:BP GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 0.00172126179615855 42 135 4 0.0296296296296296 0.0952380952380952
GO:BP GO:0030163 protein catabolic process 0.00172841120611912 974 41 9 0.219512195121951 0.00924024640657084
GO:BP GO:0045069 regulation of viral genome replication 0.0017302241240002 84 123 5 0.040650406504065 0.0595238095238095
GO:BP GO:0019079 viral genome replication 0.00175118358121258 131 123 6 0.0487804878048781 0.0458015267175573
GO:BP GO:0002544 chronic inflammatory response 0.00176119488991517 19 123 3 0.024390243902439 0.157894736842105
GO:BP GO:1901988 negative regulation of cell cycle phase transition 0.0017671133394902 281 21 4 0.19047619047619 0.0142348754448399
GO:BP GO:0070228 regulation of lymphocyte apoptotic process 0.00179022924774296 55 42 3 0.0714285714285714 0.0545454545454545
GO:BP GO:0044839 cell cycle G2/M phase transition 0.00180829492297573 283 21 4 0.19047619047619 0.0141342756183746
GO:BP GO:0016579 protein deubiquitination 0.00200910938577623 292 21 4 0.19047619047619 0.0136986301369863
GO:BP GO:0090026 positive regulation of monocyte chemotaxis 0.00201342512679225 20 123 3 0.024390243902439 0.15
GO:BP GO:0050794 regulation of cellular process 0.0021169847857708 11473 58 49 0.844827586206897 0.00427089688834655
GO:BP GO:0050801 ion homeostasis 0.00213361161447136 808 135 16 0.118518518518519 0.0198019801980198
GO:BP GO:0060828 regulation of canonical Wnt signaling pathway 0.00214527901350032 298 21 4 0.19047619047619 0.0134228187919463
GO:BP GO:0051928 positive regulation of calcium ion transport 0.00216312427085693 125 135 6 0.0444444444444444 0.048
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.00220377559034018 3483 32 15 0.46875 0.00430663221360896
GO:BP GO:0002377 immunoglobulin production 0.00221132157110178 99 111 5 0.045045045045045 0.0505050505050505
GO:BP GO:0048245 eosinophil chemotaxis 0.00222190920972839 19 135 3 0.0222222222222222 0.157894736842105
GO:BP GO:0032653 regulation of interleukin-10 production 0.00223207185289809 60 42 3 0.0714285714285714 0.05
GO:BP GO:0002224 toll-like receptor signaling pathway 0.00227969375856392 161 69 5 0.072463768115942 0.031055900621118
GO:BP GO:0140131 positive regulation of lymphocyte chemotaxis 0.00228385506105641 21 123 3 0.024390243902439 0.142857142857143
GO:BP GO:0006935 chemotaxis 0.00228779985278354 653 135 14 0.103703703703704 0.0214395099540582
GO:BP GO:0002237 response to molecule of bacterial origin 0.00231294140801272 361 135 10 0.0740740740740741 0.0277008310249307
GO:BP GO:0042330 taxis 0.00236812576297883 656 135 14 0.103703703703704 0.0213414634146341
GO:BP GO:0051094 positive regulation of developmental process 0.00240478281765727 1341 6 4 0.666666666666667 0.00298284862043251
GO:BP GO:0032613 interleukin-10 production 0.00240706084599583 62 42 3 0.0714285714285714 0.0483870967741935
GO:BP GO:0070646 protein modification by small protein removal 0.00240775954350009 310 21 4 0.19047619047619 0.0129032258064516
GO:BP GO:0009966 regulation of signal transduction 0.00246385347891222 3165 69 24 0.347826086956522 0.00758293838862559
GO:BP GO:0032501 multicellular organismal process 0.00253767421162414 7946 57 38 0.666666666666667 0.00478228039265039
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 0.00257146480734839 451 40 6 0.15 0.0133037694013304
GO:BP GO:0019222 regulation of metabolic process 0.0026151545738738 7148 24 18 0.75 0.00251818690542809
GO:BP GO:0050900 leukocyte migration 0.00264600464092257 511 135 12 0.0888888888888889 0.0234833659491194
GO:BP GO:0006887 exocytosis 0.00268910126845822 904 47 9 0.191489361702128 0.00995575221238938
GO:BP GO:0055080 cation homeostasis 0.00282110478790691 750 135 15 0.111111111111111 0.02
GO:BP GO:0070647 protein modification by small protein conjugation or removal 0.00286408204509985 1184 23 7 0.304347826086957 0.00591216216216216
GO:BP GO:0046700 heterocycle catabolic process 0.00290703029053499 602 56 8 0.142857142857143 0.0132890365448505
GO:BP GO:0030003 cellular cation homeostasis 0.00294321584641934 673 135 14 0.103703703703704 0.0208023774145617
GO:BP GO:0051336 regulation of hydrolase activity 0.00294321584641934 1321 140 22 0.157142857142857 0.0166540499621499
GO:BP GO:0030888 regulation of B cell proliferation 0.00305342012894883 63 107 4 0.0373831775700935 0.0634920634920635
GO:BP GO:0045930 negative regulation of mitotic cell cycle 0.00305342012894883 333 21 4 0.19047619047619 0.012012012012012
GO:BP GO:0044270 cellular nitrogen compound catabolic process 0.00306465996906395 608 56 8 0.142857142857143 0.0131578947368421
GO:BP GO:0098771 inorganic ion homeostasis 0.00320420622397674 761 135 15 0.111111111111111 0.0197109067017083
GO:BP GO:0048729 tissue morphogenesis 0.00331475001795532 667 40 7 0.175 0.0104947526236882
GO:BP GO:0009628 response to abiotic stimulus 0.00342215196630016 1261 43 10 0.232558139534884 0.00793021411578113
GO:BP GO:0060070 canonical Wnt signaling pathway 0.00344350645786874 345 21 4 0.19047619047619 0.0115942028985507
GO:BP GO:0006873 cellular ion homeostasis 0.00352121767567089 687 135 14 0.103703703703704 0.0203784570596798
GO:BP GO:0019439 aromatic compound catabolic process 0.00352151095983744 623 56 8 0.142857142857143 0.0128410914927769
GO:BP GO:0001959 regulation of cytokine-mediated signaling pathway 0.00361257654666356 184 68 5 0.0735294117647059 0.0271739130434783
GO:BP GO:0072677 eosinophil migration 0.00364455625706243 23 135 3 0.0222222222222222 0.130434782608696
GO:BP GO:0010524 positive regulation of calcium ion transport into cytosol 0.00370508362311655 56 55 3 0.0545454545454545 0.0535714285714286
GO:BP GO:0050789 regulation of biological process 0.00371177317492733 12091 58 50 0.862068965517241 0.00413530725332892
GO:BP GO:0006874 cellular calcium ion homeostasis 0.00371177317492733 460 135 11 0.0814814814814815 0.0239130434782609
GO:BP GO:0070227 lymphocyte apoptotic process 0.00372709872895474 74 42 3 0.0714285714285714 0.0405405405405405
GO:BP GO:1903311 regulation of mRNA metabolic process 0.00372960821793254 356 21 4 0.19047619047619 0.0112359550561798
GO:BP GO:0009892 negative regulation of metabolic process 0.00374270451442959 3479 69 25 0.36231884057971 0.00718597298074159
GO:BP GO:0032753 positive regulation of interleukin-4 production 0.00376785407924117 24 132 3 0.0227272727272727 0.125
GO:BP GO:1901987 regulation of cell cycle phase transition 0.00378801826743999 493 40 6 0.15 0.0121703853955375
GO:BP GO:0051924 regulation of calcium ion transport 0.00398655083958239 259 135 8 0.0592592592592593 0.0308880308880309
GO:BP GO:0001666 response to hypoxia 0.00412769281542616 367 21 4 0.19047619047619 0.0108991825613079
GO:BP GO:0071222 cellular response to lipopolysaccharide 0.00413483781952902 200 135 7 0.0518518518518519 0.035
GO:BP GO:0055085 transmembrane transport 0.00420310546086966 1635 41 11 0.268292682926829 0.00672782874617737
GO:BP GO:0010948 negative regulation of cell cycle process 0.00427647713294846 372 21 4 0.19047619047619 0.010752688172043
GO:BP GO:0090025 regulation of monocyte chemotaxis 0.00427647713294846 27 123 3 0.024390243902439 0.111111111111111
GO:BP GO:0065003 protein-containing complex assembly 0.00428216811443516 1680 3 3 1 0.00178571428571429
GO:BP GO:0032479 regulation of type I interferon production 0.00431950358461696 130 101 5 0.0495049504950495 0.0384615384615385
GO:BP GO:0030111 regulation of Wnt signaling pathway 0.00438759902737442 376 21 4 0.19047619047619 0.0106382978723404
GO:BP GO:1901361 organic cyclic compound catabolic process 0.00438759902737442 651 56 8 0.142857142857143 0.0122887864823349
GO:BP GO:0055074 calcium ion homeostasis 0.00438759902737442 472 135 11 0.0814814814814815 0.0233050847457627
GO:BP GO:0032606 type I interferon production 0.00440521737664617 131 101 5 0.0495049504950495 0.0381679389312977
GO:BP GO:0019752 carboxylic acid metabolic process 0.00441906881699912 1024 21 6 0.285714285714286 0.005859375
GO:BP GO:0060759 regulation of response to cytokine stimulus 0.00455209939462565 197 68 5 0.0735294117647059 0.0253807106598985
GO:BP GO:0001961 positive regulation of cytokine-mediated signaling pathway 0.00459228033678948 50 68 3 0.0441176470588235 0.06
GO:BP GO:0036293 response to decreased oxygen levels 0.00459840433637363 382 21 4 0.19047619047619 0.0104712041884817
GO:BP GO:0045862 positive regulation of proteolysis 0.00460852138489417 378 54 6 0.111111111111111 0.0158730158730159
GO:BP GO:0050920 regulation of chemotaxis 0.00464879487694575 226 123 7 0.0569105691056911 0.0309734513274336
GO:BP GO:0006402 mRNA catabolic process 0.00464879487694575 384 21 4 0.19047619047619 0.0104166666666667
GO:BP GO:0009893 positive regulation of metabolic process 0.00464879487694575 3783 32 15 0.46875 0.00396510705789056
GO:BP GO:0010646 regulation of cell communication 0.00464879487694575 3543 69 25 0.36231884057971 0.00705616709003669
GO:BP GO:2000106 regulation of leukocyte apoptotic process 0.00468675638574634 82 42 3 0.0714285714285714 0.0365853658536585
GO:BP GO:0010959 regulation of metal ion transport 0.00470212113501375 268 135 8 0.0592592592592593 0.0298507462686567
GO:BP GO:0043312 neutrophil degranulation 0.0048664981003147 482 8 3 0.375 0.00622406639004149
GO:BP GO:0002283 neutrophil activation involved in immune response 0.00493927078830945 485 8 3 0.375 0.00618556701030928
GO:BP GO:2000108 positive regulation of leukocyte apoptotic process 0.0049846125829401 29 123 3 0.024390243902439 0.103448275862069
GO:BP GO:0032496 response to lipopolysaccharide 0.00498473599387022 338 135 9 0.0666666666666667 0.0266272189349112
GO:BP GO:0043436 oxoacid metabolic process 0.00500646245848429 1057 21 6 0.285714285714286 0.00567644276253548
GO:BP GO:0051851 modulation by host of symbiont process 0.00500887683495346 65 123 4 0.032520325203252 0.0615384615384615
GO:BP GO:0023051 regulation of signaling 0.00520600922287995 3578 69 25 0.36231884057971 0.00698714365567356
GO:BP GO:0002446 neutrophil mediated immunity 0.00520600922287995 497 8 3 0.375 0.00603621730382294
GO:BP GO:0042119 neutrophil activation 0.00522262173768473 498 8 3 0.375 0.00602409638554217
GO:BP GO:0042742 defense response to bacterium 0.00522262173768473 349 132 9 0.0681818181818182 0.0257879656160458
GO:BP GO:0051649 establishment of localization in cell 0.00535449736179057 2813 19 9 0.473684210526316 0.00319943121222894
GO:BP GO:0051345 positive regulation of hydrolase activity 0.00535449736179057 783 140 15 0.107142857142857 0.0191570881226054
GO:BP GO:0036230 granulocyte activation 0.00535449736179057 504 8 3 0.375 0.00595238095238095
GO:BP GO:1904064 positive regulation of cation transmembrane transport 0.0054815312655824 150 55 4 0.0727272727272727 0.0266666666666667
GO:BP GO:0070482 response to oxygen levels 0.00552283741575752 408 21 4 0.19047619047619 0.00980392156862745
GO:BP GO:0071219 cellular response to molecule of bacterial origin 0.00553639474267468 214 135 7 0.0518518518518519 0.0327102803738318
GO:BP GO:2001056 positive regulation of cysteine-type endopeptidase activity 0.00561379404153556 154 54 4 0.0740740740740741 0.025974025974026
GO:BP GO:0006082 organic acid metabolic process 0.00569097127017604 1090 21 6 0.285714285714286 0.0055045871559633
GO:BP GO:0010522 regulation of calcium ion transport into cytosol 0.00578542869681826 106 135 5 0.037037037037037 0.0471698113207547
GO:BP GO:0070229 negative regulation of lymphocyte apoptotic process 0.00581389040791658 31 123 3 0.024390243902439 0.0967741935483871
GO:BP GO:0007259 receptor signaling pathway via JAK-STAT 0.00587472718620254 174 123 6 0.0487804878048781 0.0344827586206897
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 0.00600720216225672 497 135 11 0.0814814814814815 0.0221327967806841
GO:BP GO:0002920 regulation of humoral immune response 0.00603458690051191 133 109 5 0.0458715596330275 0.037593984962406
GO:BP GO:0043933 protein-containing complex subunit organization 0.00608163614572181 1963 3 3 1 0.00152827305145186
GO:BP GO:0060760 positive regulation of response to cytokine stimulus 0.00611943961756043 57 68 3 0.0441176470588235 0.0526315789473684
GO:BP GO:0006401 RNA catabolic process 0.00616012742159498 424 21 4 0.19047619047619 0.00943396226415094
GO:BP GO:0002221 pattern recognition receptor signaling pathway 0.00621289131561901 213 69 5 0.072463768115942 0.0234741784037559
GO:BP GO:0048513 animal organ development 0.00621289131561901 3672 8 6 0.75 0.00163398692810458
GO:BP GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 0.00648111193842602 71 123 4 0.032520325203252 0.0563380281690141
GO:BP GO:0045596 negative regulation of cell differentiation 0.00674859920646953 697 33 6 0.181818181818182 0.00860832137733142
GO:BP GO:0044265 cellular macromolecule catabolic process 0.00675144098446224 1231 41 9 0.219512195121951 0.00731112916328188
GO:BP GO:1904427 positive regulation of calcium ion transmembrane transport 0.0068608506087211 74 55 3 0.0545454545454545 0.0405405405405405
GO:BP GO:0055082 cellular chemical homeostasis 0.00703029375319539 841 135 15 0.111111111111111 0.0178359096313912
GO:BP GO:0097696 receptor signaling pathway via STAT 0.00741340420002229 184 123 6 0.0487804878048781 0.0326086956521739
GO:BP GO:0006810 transport 0.00747398679255156 5224 21 13 0.619047619047619 0.0024885145482389
GO:BP GO:0072507 divalent inorganic cation homeostasis 0.00762203082949121 516 135 11 0.0814814814814815 0.0213178294573643
GO:BP GO:0034655 nucleobase-containing compound catabolic process 0.00786292348022655 567 56 7 0.125 0.0123456790123457
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.00788075302888177 1037 123 16 0.130081300813008 0.0154291224686596
GO:BP GO:0032940 secretion by cell 0.00788657506600829 1364 8 4 0.5 0.00293255131964809
GO:BP GO:0070232 regulation of T cell apoptotic process 0.00827375453616005 36 123 3 0.024390243902439 0.0833333333333333
GO:BP GO:0071887 leukocyte apoptotic process 0.00876708412027933 108 42 3 0.0714285714285714 0.0277777777777778
GO:BP GO:0140352 export from cell 0.00887263085420923 1418 8 4 0.5 0.00282087447108604
GO:BP GO:0044772 mitotic cell cycle phase transition 0.0089283968991242 609 40 6 0.15 0.00985221674876847
GO:BP GO:0071216 cellular response to biotic stimulus 0.00900601762318607 238 135 7 0.0518518518518519 0.0294117647058824
GO:BP GO:1903169 regulation of calcium ion transmembrane transport 0.0090834308179629 158 62 4 0.0645161290322581 0.0253164556962025
GO:BP GO:0050729 positive regulation of inflammatory response 0.00910381320402572 142 69 4 0.0579710144927536 0.028169014084507
GO:BP GO:0032480 negative regulation of type I interferon production 0.00924073093611481 46 101 3 0.0297029702970297 0.0652173913043478
GO:BP GO:0051234 establishment of localization 0.00927368594344208 5372 21 13 0.619047619047619 0.00241995532390171
GO:BP GO:0051279 regulation of release of sequestered calcium ion into cytosol 0.00942098621628598 85 55 3 0.0545454545454545 0.0352941176470588
GO:BP GO:0007346 regulation of mitotic cell cycle 0.00948930091384165 619 40 6 0.15 0.00969305331179321
GO:BP GO:1901224 positive regulation of NIK/NF-kappaB signaling 0.00949852828306695 68 69 3 0.0434782608695652 0.0441176470588235
GO:BP GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 0.0098655076895628 198 123 6 0.0487804878048781 0.0303030303030303
GO:BP GO:0002455 humoral immune response mediated by circulating immunoglobulin 0.0105476424654274 156 109 5 0.0458715596330275 0.032051282051282
GO:BP GO:0032612 interleukin-1 production 0.010549493237439 126 135 5 0.037037037037037 0.0396825396825397
GO:BP GO:0042100 B cell proliferation 0.0111980412741635 98 107 4 0.0373831775700935 0.0408163265306122
GO:BP GO:0045786 negative regulation of cell cycle 0.0113113547040084 647 40 6 0.15 0.00927357032457496
GO:BP GO:0035556 intracellular signal transduction 0.0113113547040084 2772 69 20 0.289855072463768 0.00721500721500722
GO:BP GO:0016055 Wnt signaling pathway 0.011739651845471 529 21 4 0.19047619047619 0.00756143667296786
GO:BP GO:0042509 regulation of tyrosine phosphorylation of STAT protein 0.0117794679774835 87 123 4 0.032520325203252 0.0459770114942529
GO:BP GO:1901214 regulation of neuron death 0.0118013293720897 323 135 8 0.0592592592592593 0.0247678018575851
GO:BP GO:0198738 cell-cell signaling by wnt 0.0118115581491315 531 21 4 0.19047619047619 0.00753295668549906
GO:BP GO:0044770 cell cycle phase transition 0.012009152850609 658 40 6 0.15 0.00911854103343465
GO:BP GO:0007204 positive regulation of cytosolic calcium ion concentration 0.0121321844121026 325 135 8 0.0592592592592593 0.0246153846153846
GO:BP GO:0007260 tyrosine phosphorylation of STAT protein 0.0124751001745619 89 123 4 0.032520325203252 0.0449438202247191
GO:BP GO:0019538 protein metabolic process 0.0129437353371619 5808 73 35 0.479452054794521 0.00602617079889807
GO:BP GO:0030154 cell differentiation 0.0131590024001895 4350 8 6 0.75 0.00137931034482759
GO:BP GO:0065007 biological regulation 0.0141468902605834 12809 73 62 0.849315068493151 0.00484034663127488
GO:BP GO:0051050 positive regulation of transport 0.0142455982875756 923 135 15 0.111111111111111 0.0162513542795233
GO:BP GO:0048869 cellular developmental process 0.0143745891764327 4428 8 6 0.75 0.0013550135501355
GO:BP GO:0002820 negative regulation of adaptive immune response 0.0144733666261292 51 111 3 0.027027027027027 0.0588235294117647
GO:BP GO:0051246 regulation of protein metabolic process 0.0145126120792033 2704 58 17 0.293103448275862 0.00628698224852071
GO:BP GO:0051702 biological process involved in interaction with symbiont 0.0157892440908036 96 123 4 0.032520325203252 0.0416666666666667
GO:BP GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 0.0159285485937589 53 111 3 0.027027027027027 0.0566037735849057
GO:BP GO:0034767 positive regulation of ion transmembrane transport 0.0160002629166726 217 55 4 0.0727272727272727 0.0184331797235023
GO:BP GO:0034764 positive regulation of transmembrane transport 0.0160002629166726 217 55 4 0.0727272727272727 0.0184331797235023
GO:BP GO:0030449 regulation of complement activation 0.016545827012613 110 109 4 0.036697247706422 0.0363636363636364
GO:BP GO:0002889 regulation of immunoglobulin mediated immune response 0.0166343581441941 54 111 3 0.027027027027027 0.0555555555555556
GO:BP GO:0002712 regulation of B cell mediated immunity 0.0166343581441941 54 111 3 0.027027027027027 0.0555555555555556
GO:BP GO:0048878 chemical homeostasis 0.0168039668265225 1229 135 18 0.133333333333333 0.0146460537021969
GO:BP GO:0022607 cellular component assembly 0.0171078061628795 3010 3 3 1 0.000996677740863787
GO:BP GO:0006956 complement activation 0.0172831974918395 180 109 5 0.0458715596330275 0.0277777777777778
GO:BP GO:0009057 macromolecule catabolic process 0.0176828435303492 1468 41 9 0.219512195121951 0.0061307901907357
GO:BP GO:0007267 cell-cell signaling 0.0177191431848729 1722 55 12 0.218181818181818 0.00696864111498258
GO:BP GO:0051817 modulation of process of other organism involved in symbiotic interaction 0.0187476106560729 102 123 4 0.032520325203252 0.0392156862745098
GO:BP GO:0051641 cellular localization 0.018918702583619 3541 43 16 0.372093023255814 0.00451849759954815
GO:BP GO:0006968 cellular defense response 0.0190067191275658 53 121 3 0.0247933884297521 0.0566037735849057
GO:BP GO:0050790 regulation of catalytic activity 0.0196557622865999 2545 21 8 0.380952380952381 0.0031434184675835
GO:BP GO:0070231 T cell apoptotic process 0.0197784623339297 53 123 3 0.024390243902439 0.0566037735849057
GO:BP GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 0.0197784623339297 636 21 4 0.19047619047619 0.00628930817610063
GO:BP GO:0051480 regulation of cytosolic calcium ion concentration 0.0198084020938086 360 135 8 0.0592592592592593 0.0222222222222222
GO:BP GO:0007584 response to nutrient 0.0200076017379524 182 113 5 0.0442477876106195 0.0274725274725275
GO:BP GO:0051289 protein homotetramerization 0.0200076017379524 56 117 3 0.0256410256410256 0.0535714285714286
GO:BP GO:0044085 cellular component biogenesis 0.0202450930797048 3257 3 3 1 0.00092109303039607
GO:BP GO:0070997 neuron death 0.0209449492686939 365 135 8 0.0592592592592593 0.0219178082191781
GO:BP GO:0032879 regulation of localization 0.0212206490621535 2872 135 33 0.244444444444444 0.0114902506963788
GO:BP GO:0051209 release of sequestered calcium ion into cytosol 0.0212206490621535 123 55 3 0.0545454545454545 0.024390243902439
GO:BP GO:0016445 somatic diversification of immunoglobulins 0.021221980014858 61 111 3 0.027027027027027 0.0491803278688525
GO:BP GO:0051283 negative regulation of sequestering of calcium ion 0.0215347421002336 124 55 3 0.0545454545454545 0.0241935483870968
GO:BP GO:0019725 cellular homeostasis 0.021727326021155 981 135 15 0.111111111111111 0.0152905198776758
GO:BP GO:0065009 regulation of molecular function 0.0218660672839658 3221 21 9 0.428571428571429 0.00279416330332195
GO:BP GO:0051651 maintenance of location in cell 0.0218660672839658 223 135 6 0.0444444444444444 0.0269058295964126
GO:BP GO:0009612 response to mechanical stimulus 0.0218660672839658 218 32 3 0.09375 0.0137614678899083
GO:BP GO:0051282 regulation of sequestering of calcium ion 0.0218660672839658 126 55 3 0.0545454545454545 0.0238095238095238
GO:BP GO:0006915 apoptotic process 0.0222075544139514 1990 136 25 0.183823529411765 0.0125628140703518
GO:BP GO:0050864 regulation of B cell activation 0.0224791177382755 194 111 5 0.045045045045045 0.0257731958762887
GO:BP GO:0032651 regulation of interleukin-1 beta production 0.0232996419115371 102 135 4 0.0296296296296296 0.0392156862745098
GO:BP GO:0051049 regulation of transport 0.0233709453230461 1809 42 10 0.238095238095238 0.00552791597567717
GO:BP GO:0051208 sequestering of calcium ion 0.0234802788843794 130 55 3 0.0545454545454545 0.0230769230769231
GO:BP GO:0048731 system development 0.0234838063680443 5052 17 10 0.588235294117647 0.00197941409342835
GO:BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 0.0236698820588789 162 135 5 0.037037037037037 0.0308641975308642
GO:BP GO:0043269 regulation of ion transport 0.023801483750225 1379 6 3 0.5 0.00217548948513416
GO:BP GO:0033554 cellular response to stress 0.0243756765991082 2111 21 7 0.333333333333333 0.00331596399810516
GO:BP GO:0051093 negative regulation of developmental process 0.0244476105708336 977 33 6 0.181818181818182 0.00614124872057318
GO:BP GO:1904062 regulation of cation transmembrane transport 0.0245887686999815 360 62 5 0.0806451612903226 0.0138888888888889
GO:BP GO:1901564 organonitrogen compound metabolic process 0.024669010627019 6792 73 38 0.520547945205479 0.00559481743227326
GO:BP GO:0050727 regulation of inflammatory response 0.0247301947683649 381 135 8 0.0592592592592593 0.020997375328084
GO:BP GO:0051048 negative regulation of secretion 0.0248523162147117 176 42 3 0.0714285714285714 0.0170454545454545
GO:BP GO:0060402 calcium ion transport into cytosol 0.0250668823051331 165 135 5 0.037037037037037 0.0303030303030303
GO:BP GO:0002637 regulation of immunoglobulin production 0.0254625060274759 67 111 3 0.027027027027027 0.0447761194029851
GO:BP GO:0010564 regulation of cell cycle process 0.0257221016544795 809 40 6 0.15 0.00741656365883807
GO:BP GO:0010941 regulation of cell death 0.0262661076125354 1720 135 22 0.162962962962963 0.0127906976744186
GO:BP GO:0032611 interleukin-1 beta production 0.0263801601033695 107 135 4 0.0296296296296296 0.0373831775700935
GO:BP GO:0070936 protein K48-linked ubiquitination 0.0278766076676199 61 127 3 0.0236220472440945 0.0491803278688525
GO:BP GO:0044093 positive regulation of molecular function 0.0280639173926944 1771 140 23 0.164285714285714 0.012987012987013
GO:BP GO:1901222 regulation of NIK/NF-kappaB signaling 0.0283417466948765 113 69 3 0.0434782608695652 0.0265486725663717
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.0286562833223014 1477 69 12 0.173913043478261 0.00812457684495599
GO:BP GO:0097553 calcium ion transmembrane import into cytosol 0.0296054601543015 145 55 3 0.0545454545454545 0.0206896551724138
GO:BP GO:0002200 somatic diversification of immune receptors 0.0298688074317326 72 111 3 0.027027027027027 0.0416666666666667
GO:BP GO:0030335 positive regulation of cell migration 0.0303063515122151 567 135 10 0.0740740740740741 0.017636684303351
GO:BP GO:0050730 regulation of peptidyl-tyrosine phosphorylation 0.0307061514540175 269 123 6 0.0487804878048781 0.0223048327137546
GO:BP GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 0.030978942227136 148 55 3 0.0545454545454545 0.0202702702702703
GO:BP GO:2000045 regulation of G1/S transition of mitotic cell cycle 0.0313917812358276 182 131 5 0.0381679389312977 0.0274725274725275
GO:BP GO:0044267 cellular protein metabolic process 0.0314765627546303 5229 54 24 0.444444444444444 0.00458978772231784
GO:BP GO:0006958 complement activation, classical pathway 0.031749096633504 142 109 4 0.036697247706422 0.028169014084507
GO:BP GO:0042981 regulation of apoptotic process 0.0320658627565933 1549 135 20 0.148148148148148 0.012911555842479
GO:BP GO:0010942 positive regulation of cell death 0.0321423033999012 684 131 11 0.083969465648855 0.0160818713450292
GO:BP GO:0008219 cell death 0.032975350810988 2292 136 27 0.198529411764706 0.0117801047120419
GO:BP GO:0035821 modulation of process of other organism 0.033411025680033 128 123 4 0.032520325203252 0.03125
GO:BP GO:0043170 macromolecule metabolic process 0.0334819986425521 9796 59 41 0.694915254237288 0.0041853817884851
GO:BP GO:0007568 aging 0.0341582478787277 329 135 7 0.0518518518518519 0.0212765957446809
GO:BP GO:0009887 animal organ morphogenesis 0.0346458826399173 1073 24 5 0.208333333333333 0.00465983224603914
GO:BP GO:0032652 regulation of interleukin-1 production 0.0350650970818596 119 135 4 0.0296296296296296 0.0336134453781513
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0351073551551972 2541 58 15 0.258620689655172 0.00590318772136954
GO:BP GO:0051051 negative regulation of transport 0.0362220745310626 474 19 3 0.157894736842105 0.00632911392405063
GO:BP GO:0007275 multicellular organism development 0.036383949217453 5613 6 5 0.833333333333333 0.00089078923926599
GO:BP GO:0060401 cytosolic calcium ion transport 0.0367072533197327 186 135 5 0.037037037037037 0.0268817204301075
GO:BP GO:0050766 positive regulation of phagocytosis 0.0368526470376699 67 132 3 0.0227272727272727 0.0447761194029851
GO:BP GO:0043085 positive regulation of catalytic activity 0.0369439362183969 1418 140 19 0.135714285714286 0.0133991537376587
GO:BP GO:0060341 regulation of cellular localization 0.037089852689681 851 42 6 0.142857142857143 0.00705052878965922
GO:BP GO:2000147 positive regulation of cell motility 0.0371329975540264 591 135 10 0.0740740740740741 0.0169204737732657
GO:BP GO:0043067 regulation of programmed cell death 0.0378489489357415 1582 135 20 0.148148148148148 0.0126422250316056
GO:BP GO:1903047 mitotic cell cycle process 0.0396243746133969 911 40 6 0.15 0.00658616904500549
GO:BP GO:0050918 positive chemotaxis 0.0399443794338606 68 135 3 0.0222222222222222 0.0441176470588235
GO:BP GO:0051247 positive regulation of protein metabolic process 0.0401087780107602 1564 69 12 0.173913043478261 0.00767263427109974
GO:BP GO:0051272 positive regulation of cellular component movement 0.0416235493140779 604 135 10 0.0740740740740741 0.0165562913907285
GO:BP GO:0043547 positive regulation of GTPase activity 0.0416235493140779 413 140 8 0.0571428571428571 0.0193704600484262
GO:BP GO:0040017 positive regulation of locomotion 0.0423204638035385 606 135 10 0.0740740740740741 0.0165016501650165
GO:BP GO:0042113 B cell activation 0.0438427950632514 330 111 6 0.0540540540540541 0.0181818181818182
GO:BP GO:0031329 regulation of cellular catabolic process 0.0442457443326039 866 21 4 0.19047619047619 0.0046189376443418
GO:BP GO:0010812 negative regulation of cell-substrate adhesion 0.0445440099389398 69 140 3 0.0214285714285714 0.0434782608695652
GO:BP GO:0012501 programmed cell death 0.0446789567033564 2143 136 25 0.183823529411765 0.0116658889407373
GO:BP GO:0006816 calcium ion transport 0.0449396738974401 436 135 8 0.0592592592592593 0.018348623853211
GO:BP GO:0060627 regulation of vesicle-mediated transport 0.0452816911188616 536 132 9 0.0681818181818182 0.0167910447761194
GO:BP GO:0016071 mRNA metabolic process 0.0453213149716658 874 21 4 0.19047619047619 0.0045766590389016
GO:BP GO:0030334 regulation of cell migration 0.0457849111533855 999 135 14 0.103703703703704 0.014014014014014
GO:BP GO:1902806 regulation of cell cycle G1/S phase transition 0.0458463740211678 206 131 5 0.0381679389312977 0.0242718446601942
GO:BP GO:0051726 regulation of cell cycle 0.0465576745272205 1236 40 7 0.175 0.00566343042071197
GO:BP GO:0045765 regulation of angiogenesis 0.0475358044524769 358 135 7 0.0518518518518519 0.0195530726256983
GO:BP GO:0010608 posttranscriptional regulation of gene expression 0.0481052919273091 896 21 4 0.19047619047619 0.00446428571428571
GO:BP GO:0001960 negative regulation of cytokine-mediated signaling pathway 0.0484150294535493 82 123 3 0.024390243902439 0.0365853658536585
GO:BP GO:0048856 anatomical structure development 0.0491886706090897 6106 6 5 0.833333333333333 0.000818866688503112
GO:BP GO:1901575 organic substance catabolic process 0.0493261228285778 2267 56 13 0.232142857142857 0.00573445081605646
GO:BP GO:0044281 small molecule metabolic process 0.0493261228285778 1921 21 6 0.285714285714286 0.00312337324310255
GO:BP GO:0006464 cellular protein modification process 0.0499314265099958 4041 23 10 0.434782608695652 0.00247463499133878
GO:BP GO:0036211 protein modification process 0.0499314265099958 4041 23 10 0.434782608695652 0.00247463499133878
GO:CC GO:0042611 MHC protein complex 1.20961862310406e-37 24 25 15 0.6 0.625
GO:CC GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 2.22870061642121e-25 25 23 11 0.478260869565217 0.44
GO:CC GO:0098553 lumenal side of endoplasmic reticulum membrane 2.22870061642121e-25 25 23 11 0.478260869565217 0.44
GO:CC GO:0098576 lumenal side of membrane 7.22396640889448e-24 33 23 11 0.478260869565217 0.333333333333333
GO:CC GO:0012507 ER to Golgi transport vesicle membrane 1.32238062817404e-23 57 23 12 0.521739130434783 0.210526315789474
GO:CC GO:0042613 MHC class II protein complex 1.41480489497146e-21 16 25 9 0.36 0.5625
GO:CC GO:0030134 COPII-coated ER to Golgi transport vesicle 3.59350450190215e-21 90 23 12 0.521739130434783 0.133333333333333
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 2.31544966533442e-20 158 23 13 0.565217391304348 0.0822784810126582
GO:CC GO:0030666 endocytic vesicle membrane 2.31544966533442e-20 159 23 13 0.565217391304348 0.0817610062893082
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 3.71614758411939e-20 166 23 13 0.565217391304348 0.0783132530120482
GO:CC GO:0030662 coated vesicle membrane 1.07410312934012e-17 177 23 12 0.521739130434783 0.0677966101694915
GO:CC GO:0030658 transport vesicle membrane 7.5449364813774e-17 209 23 12 0.521739130434783 0.0574162679425837
GO:CC GO:0030139 endocytic vesicle 9.46570591826451e-17 306 23 13 0.565217391304348 0.042483660130719
GO:CC GO:0010008 endosome membrane 5.77537358014492e-16 505 27 15 0.555555555555556 0.0297029702970297
GO:CC GO:0042612 MHC class I protein complex 9.28037250560117e-16 8 23 6 0.260869565217391 0.75
GO:CC GO:0031301 integral component of organelle membrane 1.39498000132143e-15 382 23 13 0.565217391304348 0.0340314136125654
GO:CC GO:0031300 intrinsic component of organelle membrane 3.41996395852535e-15 413 23 13 0.565217391304348 0.0314769975786925
GO:CC GO:0030135 coated vesicle 3.41996395852535e-15 295 23 12 0.521739130434783 0.0406779661016949
GO:CC GO:0098797 plasma membrane protein complex 9.52217499799404e-15 694 25 15 0.6 0.0216138328530259
GO:CC GO:0005768 endosome 1.08506362437512e-14 987 27 17 0.62962962962963 0.0172239108409321
GO:CC GO:0030133 transport vesicle 1.65321226866326e-13 414 23 12 0.521739130434783 0.0289855072463768
GO:CC GO:0030659 cytoplasmic vesicle membrane 2.9181040720276e-13 779 23 14 0.608695652173913 0.0179717586649551
GO:CC GO:0012506 vesicle membrane 4.02419853577868e-13 800 23 14 0.608695652173913 0.0175
GO:CC GO:0005765 lysosomal membrane 6.54795781635543e-13 383 27 12 0.444444444444444 0.031331592689295
GO:CC GO:0098852 lytic vacuole membrane 6.54795781635543e-13 383 27 12 0.444444444444444 0.031331592689295
GO:CC GO:0098796 membrane protein complex 9.8006432114444e-13 1322 15 13 0.866666666666667 0.00983358547655068
GO:CC GO:0005774 vacuolar membrane 3.22733338738953e-12 441 27 12 0.444444444444444 0.0272108843537415
GO:CC GO:0031982 vesicle 7.41263937484634e-12 4055 28 24 0.857142857142857 0.00591861898890259
GO:CC GO:0098588 bounding membrane of organelle 1.07136675968475e-11 2158 27 19 0.703703703703704 0.00880444856348471
GO:CC GO:0098552 side of membrane 1.31798953028586e-11 619 23 12 0.521739130434783 0.0193861066235864
GO:CC GO:0030670 phagocytic vesicle membrane 1.31798953028586e-11 76 36 8 0.222222222222222 0.105263157894737
GO:CC GO:0009986 cell surface 2.13673176762657e-11 899 97 25 0.257731958762887 0.0278086763070078
GO:CC GO:0030669 clathrin-coated endocytic vesicle membrane 2.13673176762657e-11 36 22 6 0.272727272727273 0.166666666666667
GO:CC GO:0005789 endoplasmic reticulum membrane 2.59810727393766e-11 1117 23 14 0.608695652173913 0.0125335720680394
GO:CC GO:0098827 endoplasmic reticulum subcompartment 2.68142911846673e-11 1122 23 14 0.608695652173913 0.0124777183600713
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 3.19622348712424e-11 1139 23 14 0.608695652173913 0.0122914837576822
GO:CC GO:0045335 phagocytic vesicle 1.0190803360146e-10 137 41 9 0.219512195121951 0.0656934306569343
GO:CC GO:0098791 Golgi apparatus subcompartment 1.09566269075383e-10 885 35 15 0.428571428571429 0.0169491525423729
GO:CC GO:0000139 Golgi membrane 1.3717765965683e-10 771 23 12 0.521739130434783 0.0155642023346304
GO:CC GO:0045334 clathrin-coated endocytic vesicle 1.53901205932121e-10 54 9 5 0.555555555555556 0.0925925925925926
GO:CC GO:0000323 lytic vacuole 5.62728924465476e-10 712 27 12 0.444444444444444 0.0168539325842697
GO:CC GO:0005764 lysosome 5.62728924465476e-10 712 27 12 0.444444444444444 0.0168539325842697
GO:CC GO:0032991 protein-containing complex 5.91772743576604e-10 5548 25 23 0.92 0.00414563806777217
GO:CC GO:0031410 cytoplasmic vesicle 8.43272325215623e-10 2424 27 18 0.666666666666667 0.00742574257425743
GO:CC GO:0097708 intracellular vesicle 8.47728113422559e-10 2428 27 18 0.666666666666667 0.00741350906095552
GO:CC GO:0032588 trans-Golgi network membrane 2.25740725372387e-09 94 9 5 0.555555555555556 0.0531914893617021
GO:CC GO:0005773 vacuole 2.25740725372387e-09 810 27 12 0.444444444444444 0.0148148148148148
GO:CC GO:0031984 organelle subcompartment 3.19096310330596e-09 1773 36 18 0.5 0.0101522842639594
GO:CC GO:0055038 recycling endosome membrane 3.88981418993989e-09 84 23 6 0.260869565217391 0.0714285714285714
GO:CC GO:0030665 clathrin-coated vesicle membrane 5.65507746479904e-09 114 9 5 0.555555555555556 0.043859649122807
GO:CC GO:0042824 MHC class I peptide loading complex 8.53965899590558e-09 9 36 4 0.111111111111111 0.444444444444444
GO:CC GO:0070062 extracellular exosome 9.18950514316339e-09 2176 23 15 0.652173913043478 0.00689338235294118
GO:CC GO:0043230 extracellular organelle 1.535921240294e-08 2263 23 15 0.652173913043478 0.0066283694211224
GO:CC GO:1903561 extracellular vesicle 1.535921240294e-08 2261 23 15 0.652173913043478 0.00663423264042459
GO:CC GO:0005770 late endosome 1.78863726333209e-08 275 27 8 0.296296296296296 0.0290909090909091
GO:CC GO:0005783 endoplasmic reticulum 3.31535893612869e-08 1982 23 14 0.608695652173913 0.0070635721493441
GO:CC GO:0005794 Golgi apparatus 3.56310299036793e-08 1623 23 13 0.565217391304348 0.00800985828712261
GO:CC GO:0031090 organelle membrane 4.98870608345064e-08 3612 27 19 0.703703703703704 0.00526024363233666
GO:CC GO:0030136 clathrin-coated vesicle 5.61054080968111e-08 193 4 4 1 0.0207253886010363
GO:CC GO:0031901 early endosome membrane 1.50450759517292e-07 159 23 6 0.260869565217391 0.0377358490566038
GO:CC GO:0005802 trans-Golgi network 1.53875467796556e-07 250 4 4 1 0.016
GO:CC GO:0031902 late endosome membrane 1.94483029491727e-07 140 27 6 0.222222222222222 0.0428571428571429
GO:CC GO:0005615 extracellular space 2.95411376287309e-07 3594 123 49 0.398373983739837 0.0136338341680579
GO:CC GO:0009897 external side of plasma membrane 3.58873924892197e-07 408 107 14 0.130841121495327 0.0343137254901961
GO:CC GO:0055037 recycling endosome 3.76634250056062e-07 188 23 6 0.260869565217391 0.0319148936170213
GO:CC GO:1990111 spermatoproteasome complex 4.17900345466729e-07 5 40 3 0.075 0.6
GO:CC GO:0012505 endomembrane system 1.03024321658712e-06 4640 28 20 0.714285714285714 0.00431034482758621
GO:CC GO:0000502 proteasome complex 1.22676085531479e-06 66 40 5 0.125 0.0757575757575758
GO:CC GO:1905369 endopeptidase complex 1.87535853812794e-06 72 40 5 0.125 0.0694444444444444
GO:CC GO:0019774 proteasome core complex, beta-subunit complex 6.35368967759437e-06 11 40 3 0.075 0.272727272727273
GO:CC GO:1905368 peptidase complex 7.56652256050001e-06 96 40 5 0.125 0.0520833333333333
GO:CC GO:0043231 intracellular membrane-bounded organelle 1.02705893419704e-05 11296 25 25 1 0.00221317280453258
GO:CC GO:0005576 extracellular region 1.13466164591805e-05 4567 123 53 0.430894308943089 0.0116049923363258
GO:CC GO:0005769 early endosome 1.91299845253121e-05 378 23 6 0.260869565217391 0.0158730158730159
GO:CC GO:0005737 cytoplasm 3.6695465306106e-05 11911 25 25 1 0.00209890017630761
GO:CC GO:0016021 integral component of membrane 3.70360811980689e-05 5711 15 13 0.866666666666667 0.00227630887760462
GO:CC GO:0031224 intrinsic component of membrane 5.03043257028569e-05 5868 15 13 0.866666666666667 0.00221540558963872
GO:CC GO:0005886 plasma membrane 5.79159193073858e-05 5681 12 11 0.916666666666667 0.00193627882415068
GO:CC GO:0005839 proteasome core complex 5.79159193073858e-05 23 40 3 0.075 0.130434782608696
GO:CC GO:0043229 intracellular organelle 0.00011054956140915 12491 25 25 1 0.00200144103754703
GO:CC GO:0071944 cell periphery 0.000113851266106373 6169 62 36 0.580645161290323 0.00583562976171178
GO:CC GO:0043227 membrane-bounded organelle 0.000220303036671396 12858 25 25 1 0.00194431482345621
GO:CC GO:0140534 endoplasmic reticulum protein-containing complex 0.000352818250073332 128 36 4 0.111111111111111 0.03125
GO:CC GO:0031904 endosome lumen 0.000468266708239801 35 54 3 0.0555555555555556 0.0857142857142857
GO:CC GO:0005887 integral component of plasma membrane 0.000756442316654179 1645 8 5 0.625 0.00303951367781155
GO:CC GO:0072562 blood microparticle 0.00091212518053151 140 120 6 0.05 0.0428571428571429
GO:CC GO:0031226 intrinsic component of plasma membrane 0.000930998915508441 1726 8 5 0.625 0.00289687137891078
GO:CC GO:0043226 organelle 0.00170282170002271 14008 25 25 1 0.0017846944603084
GO:CC GO:0140535 intracellular protein-containing complex 0.00411225266041388 767 21 5 0.238095238095238 0.00651890482398957
GO:CC GO:0005622 intracellular anatomical structure 0.00636405270709423 14790 25 25 1 0.00169033130493577
GO:CC GO:0043202 lysosomal lumen 0.00822892902672375 97 54 3 0.0555555555555556 0.0309278350515464
GO:CC GO:0090734 site of DNA damage 0.00980947217672415 90 128 4 0.03125 0.0444444444444444
GO:CC GO:0030667 secretory granule membrane 0.00980947217672415 303 19 3 0.157894736842105 0.0099009900990099
GO:CC GO:0030141 secretory granule 0.0126556476912906 851 8 3 0.375 0.00352526439482961
GO:CC GO:0016020 membrane 0.0135709209818275 9838 12 11 0.916666666666667 0.00111811343769059
GO:CC GO:0099503 secretory vesicle 0.0200341060053747 1020 8 3 0.375 0.00294117647058824
GO:CC GO:1902494 catalytic complex 0.045962160993234 1441 21 5 0.238095238095238 0.00346981263011797
GO:MF GO:0042605 peptide antigen binding 1.34100603959402e-23 30 36 12 0.333333333333333 0.4
GO:MF GO:0003823 antigen binding 4.65723898739062e-15 163 23 11 0.478260869565217 0.0674846625766871
GO:MF GO:0042277 peptide binding 7.49283385503335e-14 314 23 12 0.521739130434783 0.0382165605095541
GO:MF GO:0046977 TAP binding 3.27885814590976e-13 9 36 6 0.166666666666667 0.666666666666667
GO:MF GO:0033218 amide binding 5.87524843979084e-13 389 23 12 0.521739130434783 0.0308483290488432
GO:MF GO:0023023 MHC protein complex binding 1.69079204145285e-11 25 90 8 0.0888888888888889 0.32
GO:MF GO:0023026 MHC class II protein complex binding 6.02505746723949e-11 17 90 7 0.0777777777777778 0.411764705882353
GO:MF GO:0032395 MHC class II receptor activity 7.61851962150766e-09 8 90 5 0.0555555555555556 0.625
GO:MF GO:0042608 T cell receptor binding 3.01979730638426e-08 11 23 4 0.173913043478261 0.363636363636364
GO:MF GO:0048248 CXCR3 chemokine receptor binding 9.89688875056939e-08 5 86 4 0.0465116279069767 0.8
GO:MF GO:0140375 immune receptor activity 1.05932677451108e-07 133 4 4 1 0.0300751879699248
GO:MF GO:0042379 chemokine receptor binding 1.93857168070321e-06 72 135 8 0.0592592592592593 0.111111111111111
GO:MF GO:0030881 beta-2-microglobulin binding 1.99145562331872e-06 7 23 3 0.130434782608696 0.428571428571429
GO:MF GO:0008009 chemokine activity 1.99145562331872e-06 49 135 7 0.0518518518518519 0.142857142857143
GO:MF GO:0046978 TAP1 binding 4.14053772380132e-06 6 36 3 0.0833333333333333 0.5
GO:MF GO:0045236 CXCR chemokine receptor binding 4.31178189195261e-06 18 135 5 0.037037037037037 0.277777777777778
GO:MF GO:0005102 signaling receptor binding 2.04313710396436e-05 1672 135 31 0.22962962962963 0.0185406698564593
GO:MF GO:0042287 MHC protein binding 2.27343995852717e-05 39 36 4 0.111111111111111 0.102564102564103
GO:MF GO:1990404 protein ADP-ribosylase activity 4.59487034760726e-05 16 111 4 0.036036036036036 0.25
GO:MF GO:0004298 threonine-type endopeptidase activity 7.02232086974595e-05 14 40 3 0.075 0.214285714285714
GO:MF GO:0042802 identical protein binding 8.93174932004972e-05 2067 137 34 0.248175182481752 0.0164489598451863
GO:MF GO:0005126 cytokine receptor binding 0.000101765577024736 275 135 11 0.0814814814814815 0.04
GO:MF GO:0042288 MHC class I protein binding 0.000133656112764514 20 36 3 0.0833333333333333 0.15
GO:MF GO:0031730 CCR5 chemokine receptor binding 0.00026753809804291 8 123 3 0.024390243902439 0.375
GO:MF GO:0070003 threonine-type peptidase activity 0.000302274330832288 24 40 3 0.075 0.125
GO:MF GO:0003950 NAD+ ADP-ribosyltransferase activity 0.000305073828960446 27 111 4 0.036036036036036 0.148148148148148
GO:MF GO:0042803 protein homodimerization activity 0.000314357359463691 676 131 16 0.122137404580153 0.0236686390532544
GO:MF GO:0016763 transferase activity, transferring pentosyl groups 0.000314357359463691 56 111 5 0.045045045045045 0.0892857142857143
GO:MF GO:0004888 transmembrane signaling receptor activity 0.000314357359463691 1269 4 4 1 0.00315208825847124
GO:MF GO:0048020 CCR chemokine receptor binding 0.000351081348512658 48 135 5 0.037037037037037 0.104166666666667
GO:MF GO:0004175 endopeptidase activity 0.000355834863555668 450 136 13 0.0955882352941176 0.0288888888888889
GO:MF GO:0060089 molecular transducer activity 0.000461572856645642 1458 4 4 1 0.00274348422496571
GO:MF GO:0038023 signaling receptor activity 0.000461572856645642 1458 4 4 1 0.00274348422496571
GO:MF GO:0005125 cytokine activity 0.000623450940956867 235 135 9 0.0666666666666667 0.0382978723404255
GO:MF GO:0008233 peptidase activity 0.000820329100585741 646 136 15 0.110294117647059 0.0232198142414861
GO:MF GO:0044877 protein-containing complex binding 0.00192739177593524 1287 45 11 0.244444444444444 0.00854700854700855
GO:MF GO:0048018 receptor ligand activity 0.00257585093526741 494 135 12 0.0888888888888889 0.0242914979757085
GO:MF GO:0004252 serine-type endopeptidase activity 0.00260827735667843 171 136 7 0.0514705882352941 0.0409356725146199
GO:MF GO:0001664 G protein-coupled receptor binding 0.00267527378249877 292 135 9 0.0666666666666667 0.0308219178082192
GO:MF GO:0030546 signaling receptor activator activity 0.0026932665318106 501 135 12 0.0888888888888889 0.0239520958083832
GO:MF GO:0008236 serine-type peptidase activity 0.00431518609441441 189 136 7 0.0514705882352941 0.037037037037037
GO:MF GO:0017171 serine hydrolase activity 0.00479735719008619 193 136 7 0.0514705882352941 0.0362694300518135
GO:MF GO:0098772 molecular function regulator 0.00502360966463116 2363 140 32 0.228571428571429 0.0135421074904782
GO:MF GO:0030545 receptor regulator activity 0.00511136800481163 545 135 12 0.0888888888888889 0.0220183486238532
GO:MF GO:0005164 tumor necrosis factor receptor binding 0.00611156339123549 32 105 3 0.0285714285714286 0.09375
GO:MF GO:0140096 catalytic activity, acting on a protein 0.00665549327838424 2332 139 31 0.223021582733813 0.0132933104631218
GO:MF GO:0061135 endopeptidase regulator activity 0.0086518024351163 188 21 3 0.142857142857143 0.0159574468085106
GO:MF GO:0005525 GTP binding 0.00898173727536685 381 80 7 0.0875 0.0183727034120735
GO:MF GO:0032550 purine ribonucleoside binding 0.00939183207244835 386 80 7 0.0875 0.0181347150259067
GO:MF GO:0046983 protein dimerization activity 0.00939183207244835 1069 131 17 0.129770992366412 0.0159027128157156
GO:MF GO:0032549 ribonucleoside binding 0.00953361786807994 389 80 7 0.0875 0.0179948586118252
GO:MF GO:0001883 purine nucleoside binding 0.00953361786807994 389 80 7 0.0875 0.0179948586118252
GO:MF GO:0001882 nucleoside binding 0.0102571122908542 395 80 7 0.0875 0.0177215189873418
GO:MF GO:0043394 proteoglycan binding 0.010564226549904 36 120 3 0.025 0.0833333333333333
GO:MF GO:0032561 guanyl ribonucleotide binding 0.0110252004958694 403 80 7 0.0875 0.0173697270471464
GO:MF GO:0019001 guanyl nucleotide binding 0.0110252004958694 403 80 7 0.0875 0.0173697270471464
GO:MF GO:0061134 peptidase regulator activity 0.01188222070717 224 21 3 0.142857142857143 0.0133928571428571
GO:MF GO:0042056 chemoattractant activity 0.0143879550489605 37 135 3 0.0222222222222222 0.0810810810810811
GO:MF GO:0032813 tumor necrosis factor receptor superfamily binding 0.0154304631352756 49 105 3 0.0285714285714286 0.0612244897959184
GO:MF GO:0016787 hydrolase activity 0.0168753259674024 2615 129 30 0.232558139534884 0.011472275334608
GO:MF GO:0005515 protein binding 0.0212989906993251 14767 71 65 0.915492957746479 0.00440170650775378
GO:MF GO:0097367 carbohydrate derivative binding 0.021631705265114 2285 88 20 0.227272727272727 0.0087527352297593
GO:MF GO:0005539 glycosaminoglycan binding 0.0223982369485956 238 120 6 0.05 0.0252100840336134
GO:MF GO:0008201 heparin binding 0.0227447084760032 168 120 5 0.0416666666666667 0.0297619047619048
GO:MF GO:0019955 cytokine binding 0.0255376306253019 138 97 4 0.0412371134020619 0.0289855072463768
GO:MF GO:0003924 GTPase activity 0.0418370417458506 328 106 6 0.0566037735849057 0.0182926829268293
GO:MF GO:0003714 transcription corepressor activity 0.0461917448098832 187 89 4 0.0449438202247191 0.0213903743315508
HP HP:0011122 Abnormality of skin physiology 2.31717580895823e-05 430 13 10 0.769230769230769 0.0232558139534884
HP HP:0011123 Inflammatory abnormality of the skin 6.78537850994437e-05 367 13 9 0.692307692307692 0.0245231607629428
HP HP:0003565 Elevated erythrocyte sedimentation rate 6.78537850994437e-05 48 13 5 0.384615384615385 0.104166666666667
HP HP:0025021 Abnormal erythrocyte sedimentation rate 6.78537850994437e-05 49 13 5 0.384615384615385 0.102040816326531
HP HP:0100533 Inflammatory abnormality of the eye 8.60918544132623e-05 193 13 7 0.538461538461538 0.0362694300518135
HP HP:0003765 Psoriasiform dermatitis 8.60918544132623e-05 25 11 4 0.363636363636364 0.16
HP HP:0001701 Pericarditis 8.60918544132623e-05 34 9 4 0.444444444444444 0.117647058823529
HP HP:0045073 Serositis 0.000131246186708986 40 9 4 0.444444444444444 0.1
HP HP:0033331 Acute phase response 0.000131246186708986 65 13 5 0.384615384615385 0.0769230769230769
HP HP:0000988 Skin rash 0.000201293752413128 114 9 5 0.555555555555556 0.043859649122807
HP HP:0100749 Chest pain 0.000233523002328303 93 11 5 0.454545454545455 0.0537634408602151
HP HP:0002113 Pulmonary infiltrates 0.00031173696776463 53 9 4 0.444444444444444 0.0754716981132075
HP HP:0002829 Arthralgia 0.00037211225353837 161 13 6 0.461538461538462 0.0372670807453416
HP HP:0002105 Hemoptysis 0.000413068523823357 59 9 4 0.444444444444444 0.0677966101694915
HP HP:0000509 Conjunctivitis 0.000598650859485448 98 13 5 0.384615384615385 0.0510204081632653
HP HP:0001697 Abnormal pericardium morphology 0.000603783226881345 68 9 4 0.444444444444444 0.0588235294117647
HP HP:0025337 Red eye 0.000603783226881345 100 13 5 0.384615384615385 0.05
HP HP:0012735 Cough 0.000645998838690602 128 11 5 0.454545454545455 0.0390625
HP HP:0031983 Abnormal pulmonary thoracic imaging finding 0.000645998838690602 71 9 4 0.444444444444444 0.0563380281690141
HP HP:0001287 Meningitis 0.000645998838690602 72 9 4 0.444444444444444 0.0555555555555556
HP HP:0011227 Elevated C-reactive protein level 0.000835632863842384 51 13 4 0.307692307692308 0.0784313725490196
HP HP:0002091 Restrictive ventilatory defect 0.000857363763636463 80 9 4 0.444444444444444 0.05
HP HP:0032436 Abnormal C-reactive protein level 0.000857363763636463 52 13 4 0.307692307692308 0.0769230769230769
HP HP:0002102 Pleuritis 0.000935494672340329 25 9 3 0.333333333333333 0.12
HP HP:0002103 Abnormal pleura morphology 0.000958823769091669 84 9 4 0.444444444444444 0.0476190476190476
HP HP:0011450 Unusual CNS infection 0.00106069006659212 87 9 4 0.444444444444444 0.0459770114942529
HP HP:0001824 Weight loss 0.0010921415979816 273 11 6 0.545454545454545 0.021978021978022
HP HP:0200042 Skin ulcer 0.0010921415979816 115 14 5 0.357142857142857 0.0434782608695652
HP HP:0032158 Unusual infection by anatomical site 0.00113771864525245 91 9 4 0.444444444444444 0.043956043956044
HP HP:0000246 Sinusitis 0.00150941827811339 125 14 5 0.357142857142857 0.04
HP HP:0000502 Abnormal conjunctiva morphology 0.00172776385366944 141 13 5 0.384615384615385 0.0354609929078014
HP HP:0001097 Keratoconjunctivitis sicca 0.00174300875066392 39 8 3 0.375 0.0769230769230769
HP HP:0032016 Abnormal sputum 0.00174300875066392 106 9 4 0.444444444444444 0.0377358490566038
HP HP:0001426 Multifactorial inheritance 0.00174300875066392 84 11 4 0.363636363636364 0.0476190476190476
HP HP:0000763 Sensory neuropathy 0.00195310554557297 182 11 5 0.454545454545455 0.0274725274725275
HP HP:0001096 Keratoconjunctivitis 0.00214595162194157 43 8 3 0.375 0.0697674418604651
HP HP:0000245 Abnormal paranasal sinus morphology 0.00222916513084722 143 14 5 0.357142857142857 0.034965034965035
HP HP:0012647 Abnormal inflammatory response 0.00229209870703601 914 14 10 0.714285714285714 0.0109409190371991
HP HP:0012649 Increased inflammatory response 0.00229209870703601 914 14 10 0.714285714285714 0.0109409190371991
HP HP:0100820 Glomerulopathy 0.00262290654862846 42 9 3 0.333333333333333 0.0714285714285714
HP HP:0030878 Abnormality on pulmonary function testing 0.00296168186484014 128 9 4 0.444444444444444 0.03125
HP HP:0002719 Recurrent infections 0.00321962653386963 745 14 9 0.642857142857143 0.0120805369127517
HP HP:0001945 Fever 0.00331116895854205 294 13 6 0.461538461538462 0.0204081632653061
HP HP:0000969 Edema 0.00372261005080971 489 9 6 0.666666666666667 0.0122699386503067
HP HP:0002239 Gastrointestinal hemorrhage 0.00372261005080971 141 9 4 0.444444444444444 0.0283687943262411
HP HP:0100758 Gangrene 0.0041165419167552 52 9 3 0.333333333333333 0.0576923076923077
HP HP:0032101 Unusual infection 0.00468753962060952 792 14 9 0.642857142857143 0.0113636363636364
HP HP:0000822 Hypertension 0.00482775648927618 306 9 5 0.555555555555556 0.0163398692810458
HP HP:0000873 Diabetes insipidus 0.0051215250880661 57 9 3 0.333333333333333 0.0526315789473684
HP HP:0100539 Periorbital edema 0.0057583110319992 60 9 3 0.333333333333333 0.05
HP HP:0000491 Keratitis 0.00660542013269737 74 8 3 0.375 0.0405405405405405
HP HP:0011032 Abnormality of fluid regulation 0.00660542013269737 562 9 6 0.666666666666667 0.0106761565836299
HP HP:0010783 Erythema 0.00660542013269737 113 13 4 0.307692307692308 0.0353982300884956
HP HP:0001369 Arthritis 0.00660542013269737 196 8 4 0.5 0.0204081632653061
HP HP:0002633 Vasculitis 0.00660542013269737 65 9 3 0.333333333333333 0.0461538461538462
HP HP:0032263 Increased blood pressure 0.00752700018384323 350 9 5 0.555555555555556 0.0142857142857143
HP HP:0002206 Pulmonary fibrosis 0.00752700018384323 69 9 3 0.333333333333333 0.0434782608695652
HP HP:0000282 Facial edema 0.00752700018384323 69 9 3 0.333333333333333 0.0434782608695652
HP HP:0030355 Abnormal serum interferon-gamma level 0.00755389277515176 11 56 3 0.0535714285714286 0.272727272727273
HP HP:0030354 Abnormal serum interferon level 0.00755389277515176 11 56 3 0.0535714285714286 0.272727272727273
HP HP:0002960 Autoimmunity 0.0090968125309544 170 73 10 0.136986301369863 0.0588235294117647
HP HP:0001733 Pancreatitis 0.0090968125309544 76 9 3 0.333333333333333 0.0394736842105263
HP HP:0200034 Papule 0.00964328965589076 78 9 3 0.333333333333333 0.0384615384615385
HP HP:0004936 Venous thrombosis 0.0107390565599849 82 9 3 0.333333333333333 0.0365853658536585
HP HP:0012575 Abnormal nephron morphology 0.0107772303330332 208 9 4 0.444444444444444 0.0192307692307692
HP HP:0004370 Abnormality of temperature regulation 0.0107772303330332 398 13 6 0.461538461538462 0.0150753768844221
HP HP:0000022 Abnormality of male internal genitalia 0.0114960795121083 57 13 3 0.230769230769231 0.0526315789473684
HP HP:0011495 Abnormal corneal epithelium morphology 0.0135210758456252 103 8 3 0.375 0.029126213592233
HP HP:0030972 Abnormal systemic blood pressure 0.0145885063216851 423 9 5 0.555555555555556 0.0118203309692671
HP HP:0011947 Respiratory tract infection 0.0148704818268207 558 14 7 0.5 0.0125448028673835
HP HP:0008066 Abnormal blistering of the skin 0.0160532106565639 78 11 3 0.272727272727273 0.0384615384615385
HP HP:0002637 Cerebral ischemia 0.0165212950728408 99 9 3 0.333333333333333 0.0303030303030303
HP HP:0033401 Tissue ischemia 0.0165212950728408 99 9 3 0.333333333333333 0.0303030303030303
HP HP:0012531 Pain 0.0179955065851962 636 13 7 0.538461538461538 0.0110062893081761
HP HP:0030163 Abnormal vascular physiology 0.0186933960722413 248 9 4 0.444444444444444 0.0161290322580645
HP HP:0002027 Abdominal pain 0.0192381437894662 251 9 4 0.444444444444444 0.0159362549800797
HP HP:0004374 Hemiplegia/hemiparesis 0.0192381437894662 199 11 4 0.363636363636364 0.0201005025125628
HP HP:0000488 Retinopathy 0.0199190567077615 108 9 3 0.333333333333333 0.0277777777777778
HP HP:0009830 Peripheral neuropathy 0.0233267291320862 588 11 6 0.545454545454545 0.0102040816326531
HP HP:0010876 Abnormal circulating protein concentration 0.0233267291320862 480 13 6 0.461538461538462 0.0125
HP HP:0003401 Paresthesia 0.0235231040756702 96 11 3 0.272727272727273 0.03125
HP HP:0008047 Abnormality of the vasculature of the eye 0.0235231040756702 319 8 4 0.5 0.0125391849529781
HP HP:0001977 Abnormal thrombosis 0.0235231040756702 120 9 3 0.333333333333333 0.025
HP HP:0011029 Internal hemorrhage 0.0245196611156925 282 9 4 0.444444444444444 0.0141843971631206
HP HP:0011276 Vascular skin abnormality 0.0245196611156925 493 13 6 0.461538461538462 0.0121703853955375
HP HP:0031910 Abnormal cranial nerve physiology 0.0249359594477871 288 9 4 0.444444444444444 0.0138888888888889
HP HP:0001881 Abnormal leukocyte morphology 0.0249359594477871 510 9 5 0.555555555555556 0.00980392156862745
HP HP:0002716 Lymphadenopathy 0.0249359594477871 187 13 4 0.307692307692308 0.0213903743315508
HP HP:0010987 Abnormal cellular immune system morphology 0.0249359594477871 510 9 5 0.555555555555556 0.00980392156862745
HP HP:0006824 Cranial nerve paralysis 0.0249359594477871 287 9 4 0.444444444444444 0.0139372822299652
HP HP:0010978 Abnormality of immune system physiology 0.0249626347698135 1346 14 10 0.714285714285714 0.00742942050520059
HP HP:0025142 Constitutional symptom 0.0253357443683905 939 13 8 0.615384615384615 0.00851970181043664
HP HP:0025323 Abnormal arterial physiology 0.0258289563698038 130 9 3 0.333333333333333 0.0230769230769231
HP HP:0002733 Abnormality of the lymph nodes 0.0258289563698038 196 13 4 0.307692307692308 0.0204081632653061
HP HP:0002205 Recurrent respiratory infections 0.0258289563698038 468 14 6 0.428571428571429 0.0128205128205128
HP HP:0012733 Macule 0.0258289563698038 106 11 3 0.272727272727273 0.0283018867924528
HP HP:0001744 Splenomegaly 0.0259690671659964 345 8 4 0.5 0.0115942028985507
HP HP:0032251 Abnormal immune system morphology 0.0262615987427475 532 9 5 0.555555555555556 0.0093984962406015
HP HP:0012091 Abnormality of pancreas physiology 0.0267699507401918 136 9 3 0.333333333333333 0.0220588235294118
HP HP:0010701 Abnormal immunoglobulin level 0.0268260794361516 219 6 3 0.5 0.0136986301369863
HP HP:0010702 Increased circulating antibody level 0.0268260794361516 92 13 3 0.230769230769231 0.0326086956521739
HP HP:0011028 Abnormality of blood circulation 0.0268260794361516 306 9 4 0.444444444444444 0.0130718954248366
HP HP:0005372 Abnormality of B cell physiology 0.0269858913170111 220 6 3 0.5 0.0136363636363636
HP HP:0000790 Hematuria 0.0272883993241668 140 9 3 0.333333333333333 0.0214285714285714
HP HP:0012614 Abnormal urine cytology 0.0272883993241668 140 9 3 0.333333333333333 0.0214285714285714
HP HP:0006530 Abnormal pulmonary Interstitial morphology 0.0272883993241668 140 9 3 0.333333333333333 0.0214285714285714
HP HP:0010974 Abnormal myeloid leukocyte morphology 0.0272883993241668 312 9 4 0.444444444444444 0.0128205128205128
HP HP:0003326 Myalgia 0.0272883993241668 140 9 3 0.333333333333333 0.0214285714285714
HP HP:0012252 Abnormal respiratory system morphology 0.0290080149425047 1137 14 9 0.642857142857143 0.0079155672823219
HP HP:0002110 Bronchiectasis 0.0290080149425047 119 36 5 0.138888888888889 0.0420168067226891
HP HP:0100755 Abnormality of salivation 0.0320443530933165 172 8 3 0.375 0.0174418604651163
HP HP:0011112 Abnormality of serum cytokine level 0.0323510647753324 23 56 3 0.0535714285714286 0.130434782608696
HP HP:0002354 Memory impairment 0.0332102242365564 123 11 3 0.272727272727273 0.024390243902439
HP HP:0012378 Fatigue 0.0332210509715629 335 9 4 0.444444444444444 0.0119402985074627
HP HP:0031409 Abnormal lymphocyte physiology 0.0334044761543684 246 6 3 0.5 0.0121951219512195
HP HP:0000083 Renal insufficiency 0.0335232094106596 337 9 4 0.444444444444444 0.0118694362017804
HP HP:0005368 Abnormality of humoral immunity 0.034149186195781 249 6 3 0.5 0.0120481927710843
HP HP:0000095 Abnormal renal glomerulus morphology 0.0345864346060774 158 9 3 0.333333333333333 0.0189873417721519
HP HP:0011111 Abnormality of immune serum protein physiology 0.0345864346060774 24 56 3 0.0535714285714286 0.125
HP HP:0031263 Abnormal renal corpuscle morphology 0.0345864346060774 158 9 3 0.333333333333333 0.0189873417721519
HP HP:0011675 Arrhythmia 0.0346079789710122 381 13 5 0.384615384615385 0.0131233595800525
HP HP:0000093 Proteinuria 0.0400738494765367 168 9 3 0.333333333333333 0.0178571428571429
HP HP:0002088 Abnormal lung morphology 0.0400738494765367 960 14 8 0.571428571428571 0.00833333333333333
HP HP:0012211 Abnormal renal physiology 0.0400738494765367 614 9 5 0.555555555555556 0.00814332247557003
HP HP:0002024 Malabsorption 0.0414587723596119 195 8 3 0.375 0.0153846153846154
HP HP:0002037 Inflammation of the large intestine 0.0434884538502253 62 24 3 0.125 0.0483870967741935
HP HP:0011799 Abnormality of facial soft tissue 0.0445000973545186 413 13 5 0.384615384615385 0.0121065375302663
HP HP:0020129 Abnormal urine protein level 0.0445000973545186 181 9 3 0.333333333333333 0.0165745856353591
HP HP:0002087 Abnormality of the upper respiratory tract 0.0446143276651034 382 14 5 0.357142857142857 0.0130890052356021
HP HP:0025426 Abnormal bronchus morphology 0.0454798529096364 140 36 5 0.138888888888889 0.0357142857142857
HP HP:0030956 Abnormality of cardiovascular system electrophysiology 0.0468984631474403 424 13 5 0.384615384615385 0.0117924528301887
HP HP:0011035 Abnormal renal cortex morphology 0.0468984631474403 187 9 3 0.333333333333333 0.0160427807486631
HP HP:0000951 Abnormality of the skin 0.0472747816541248 1868 9 8 0.888888888888889 0.00428265524625268
HP HP:0031815 Abnormal oral physiology 0.0484288482226132 218 8 3 0.375 0.0137614678899083
HP HP:0000388 Otitis media 0.0499750468053343 245 14 4 0.285714285714286 0.0163265306122449
HPA HPA:0310443 lymph node; non-germinal center cells[High] 5.02000652921445e-05 1169 84 27 0.321428571428571 0.0230966638152267
HPA HPA:0530722 spleen; cells in white pulp[≥Medium] 0.00043117988413457 2645 26 18 0.692307692307692 0.00680529300567108
HPA HPA:0310433 lymph node; germinal center cells[High] 0.000501976919357029 908 26 11 0.423076923076923 0.0121145374449339
HPA HPA:0310432 lymph node; germinal center cells[≥Medium] 0.000715823380109997 3209 26 19 0.730769230769231 0.00592084761607978
HPA HPA:0600443 tonsil; non-germinal center cells[High] 0.00103682288810088 1271 12 8 0.666666666666667 0.00629425649095201
HPA HPA:0310442 lymph node; non-germinal center cells[≥Medium] 0.00110958917418223 3875 14 13 0.928571428571429 0.00335483870967742
HPA HPA:0030072 appendix; lymphoid tissue[≥Medium] 0.00110958917418223 3131 14 12 0.857142857142857 0.00383264132864899
HPA HPA:0600432 tonsil; germinal center cells[≥Medium] 0.00123941018626317 3988 14 13 0.928571428571429 0.00325977933801404
HPA HPA:0600442 tonsil; non-germinal center cells[≥Medium] 0.00146015019018083 4079 14 13 0.928571428571429 0.00318705565089483
HPA HPA:0600433 tonsil; germinal center cells[High] 0.00180578904220915 1179 11 7 0.636363636363636 0.00593723494486853
HPA HPA:0530721 spleen; cells in white pulp[≥Low] 0.00198680585889477 4249 14 13 0.928571428571429 0.00305954342198164
HPA HPA:0530712 spleen; cells in red pulp[≥Medium] 0.00337748386435472 3049 26 17 0.653846153846154 0.0055755985569039
HPA HPA:0300412 lung; macrophages[≥Medium] 0.003736977670397 4732 29 23 0.793103448275862 0.00486052409129332
HPA HPA:0300413 lung; macrophages[High] 0.00441690842280475 1224 20 9 0.45 0.00735294117647059
HPA HPA:0211092 fallopian tube; non-ciliated cells[≥Medium] 0.00441690842280475 328 10 4 0.4 0.0121951219512195
HPA HPA:0310431 lymph node; germinal center cells[≥Low] 0.00700708801956762 4935 26 21 0.807692307692308 0.00425531914893617
HPA HPA:0030071 appendix; lymphoid tissue[≥Low] 0.00809713021808194 4976 14 13 0.928571428571429 0.00261254019292604
HPA HPA:0211091 fallopian tube; non-ciliated cells[≥Low] 0.0113391848284426 456 10 4 0.4 0.0087719298245614
HPA HPA:0530711 spleen; cells in red pulp[≥Low] 0.0118433244638701 5195 14 13 0.928571428571429 0.00250240615976901
HPA HPA:0530723 spleen; cells in white pulp[High] 0.0138083873432713 811 11 5 0.454545454545455 0.0061652281134402
HPA HPA:0460642 skin 1; Langerhans[≥Medium] 0.0198251801453468 3123 14 10 0.714285714285714 0.0032020493115594
HPA HPA:0460643 skin 1; Langerhans[High] 0.0261612996142597 734 14 5 0.357142857142857 0.00681198910081744
HPA HPA:0270352 kidney; cells in glomeruli[≥Medium] 0.0289604563072059 2914 20 12 0.6 0.00411805078929307
HPA HPA:0530000 spleen 0.0291204565510125 5756 14 13 0.928571428571429 0.0022585128561501
HPA HPA:0600431 tonsil; germinal center cells[≥Low] 0.0339188951518282 5845 14 13 0.928571428571429 0.00222412318220701
HPA HPA:0310441 lymph node; non-germinal center cells[≥Low] 0.0379338716108611 5915 14 13 0.928571428571429 0.0021978021978022
HPA HPA:0600441 tonsil; non-germinal center cells[≥Low] 0.0407995265654715 5966 14 13 0.928571428571429 0.00217901441501844
KEGG KEGG:04612 Antigen processing and presentation 3.41457003466494e-31 69 25 18 0.72 0.260869565217391
KEGG KEGG:05330 Allograft rejection 3.18406203468232e-24 34 25 13 0.52 0.382352941176471
KEGG KEGG:05332 Graft-versus-host disease 8.1147967357042e-24 37 25 13 0.52 0.351351351351351
KEGG KEGG:04940 Type I diabetes mellitus 2.04713392577899e-23 40 25 13 0.52 0.325
KEGG KEGG:05320 Autoimmune thyroid disease 3.52914000901113e-22 49 25 13 0.52 0.26530612244898
KEGG KEGG:05416 Viral myocarditis 2.0959362258473e-21 56 25 13 0.52 0.232142857142857
KEGG KEGG:05169 Epstein-Barr virus infection 3.07914858897212e-19 198 25 16 0.64 0.0808080808080808
KEGG KEGG:04145 Phagosome 1.48791190430316e-17 147 25 14 0.56 0.0952380952380952
KEGG KEGG:05168 Herpes simplex virus 1 infection 5.35932252677818e-16 494 25 18 0.72 0.0364372469635627
KEGG KEGG:04514 Cell adhesion molecules 7.43641128873114e-16 146 25 13 0.52 0.089041095890411
KEGG KEGG:05166 Human T-cell leukemia virus 1 infection 2.66369768871992e-15 216 25 14 0.56 0.0648148148148148
KEGG KEGG:05310 Asthma 3.42399616718515e-14 27 132 12 0.0909090909090909 0.444444444444444
KEGG KEGG:04672 Intestinal immune network for IgA production 9.72271183103954e-14 45 107 13 0.121495327102804 0.288888888888889
KEGG KEGG:05321 Inflammatory bowel disease 8.68353387151345e-13 62 25 9 0.36 0.145161290322581
KEGG KEGG:05140 Leishmaniasis 3.33921794480291e-12 72 25 9 0.36 0.125
KEGG KEGG:04658 Th1 and Th2 cell differentiation 2.26682105395934e-11 89 25 9 0.36 0.101123595505618
KEGG KEGG:05150 Staphylococcus aureus infection 5.36759435210676e-11 87 109 14 0.128440366972477 0.160919540229885
KEGG KEGG:04659 Th17 cell differentiation 8.47518321058457e-11 104 25 9 0.36 0.0865384615384615
KEGG KEGG:05145 Toxoplasmosis 1.23464009528049e-10 109 25 9 0.36 0.0825688073394495
KEGG KEGG:05152 Tuberculosis 2.83873084972289e-10 175 25 10 0.4 0.0571428571428571
KEGG KEGG:05323 Rheumatoid arthritis 8.15357896938181e-10 88 25 8 0.32 0.0909090909090909
KEGG KEGG:04640 Hematopoietic cell lineage 1.45228813331898e-09 95 25 8 0.32 0.0842105263157895
KEGG KEGG:05164 Influenza A 3.0278065448793e-09 169 32 10 0.3125 0.0591715976331361
KEGG KEGG:05322 Systemic lupus erythematosus 1.16115791123941e-08 132 109 14 0.128440366972477 0.106060606060606
KEGG KEGG:05170 Human immunodeficiency virus 1 infection 3.27924263856806e-07 210 23 8 0.347826086956522 0.0380952380952381
KEGG KEGG:05163 Human cytomegalovirus infection 8.1365216002487e-06 223 15 6 0.4 0.0269058295964126
KEGG KEGG:03050 Proteasome 1.25402476433669e-05 46 40 5 0.125 0.108695652173913
KEGG KEGG:05167 Kaposi sarcoma-associated herpesvirus infection 7.25711708413514e-05 193 24 6 0.25 0.0310880829015544
KEGG KEGG:04061 Viral protein interaction with cytokine and cytokine receptor 0.000153847935648785 98 135 9 0.0666666666666667 0.0918367346938776
KEGG KEGG:04218 Cellular senescence 0.000265529951879381 156 23 5 0.217391304347826 0.032051282051282
KEGG KEGG:05165 Human papillomavirus infection 0.00053035693821206 331 29 7 0.241379310344828 0.0211480362537764
KEGG KEGG:05203 Viral carcinogenesis 0.000842994506999791 202 23 5 0.217391304347826 0.0247524752475248
KEGG KEGG:05340 Primary immunodeficiency 0.000938812888087625 37 126 5 0.0396825396825397 0.135135135135135
KEGG KEGG:04650 Natural killer cell mediated cytotoxicity 0.00131456074713706 123 23 4 0.173913043478261 0.032520325203252
KEGG KEGG:04144 Endocytosis 0.00213918803741354 252 23 5 0.217391304347826 0.0198412698412698
KEGG KEGG:04620 Toll-like receptor signaling pathway 0.00312021124756966 102 123 7 0.0569105691056911 0.0686274509803922
KEGG KEGG:04060 Cytokine-cytokine receptor interaction 0.00417217868945516 293 135 13 0.0962962962962963 0.0443686006825939
KEGG KEGG:05133 Pertussis 0.0114956302373419 76 109 5 0.0458715596330275 0.0657894736842105
KEGG KEGG:04610 Complement and coagulation cascades 0.0176092563205241 85 109 5 0.0458715596330275 0.0588235294117647
KEGG KEGG:04621 NOD-like receptor signaling pathway 0.0176092563205241 177 123 8 0.0650406504065041 0.0451977401129944
KEGG KEGG:04062 Chemokine signaling pathway 0.0423475215095323 190 135 8 0.0592592592592593 0.0421052631578947
KEGG KEGG:04623 Cytosolic DNA-sensing pathway 0.0423475215095323 62 123 4 0.032520325203252 0.0645161290322581
MIRNA MIRNA:hsa-miR-146a-5p hsa-miR-146a-5p 3.8670440478953e-05 200 91 11 0.120879120879121 0.055
REAC REAC:R-HSA-913531 Interferon Signaling 2.44539891206601e-25 191 79 27 0.341772151898734 0.141361256544503
REAC REAC:R-HSA-877300 Interferon gamma signaling 8.70158844202861e-19 87 35 14 0.4 0.160919540229885
REAC REAC:R-HSA-1236975 Antigen processing-Cross presentation 4.89419842034846e-17 99 41 14 0.341463414634146 0.141414141414141
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 4.89419842034846e-17 842 35 24 0.685714285714286 0.0285035629453682
REAC REAC:R-HSA-909733 Interferon alpha/beta signaling 4.89419842034846e-17 66 79 15 0.189873417721519 0.227272727272727
REAC REAC:R-HSA-1280218 Adaptive Immune System 7.46856440177517e-17 800 25 20 0.8 0.025
REAC REAC:R-HSA-1236974 ER-Phagosome pathway 9.19691364874275e-17 83 40 13 0.325 0.156626506024096
REAC REAC:R-HSA-168256 Immune System 6.81954804063536e-15 2139 58 41 0.706896551724138 0.0191678354371202
REAC REAC:R-HSA-1236977 Endosomal/Vacuolar pathway 1.07740335765455e-13 11 41 7 0.170731707317073 0.636363636363636
REAC REAC:R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 3.15543646704656e-13 25 36 8 0.222222222222222 0.32
REAC REAC:R-HSA-202424 Downstream TCR signaling 5.52527108785583e-12 98 22 9 0.409090909090909 0.0918367346938776
REAC REAC:R-HSA-202403 TCR signaling 3.2835630534374e-11 120 22 9 0.409090909090909 0.075
REAC REAC:R-HSA-983169 Class I MHC mediated antigen processing & presentation 8.14244744523474e-11 370 23 12 0.521739130434783 0.0324324324324324
REAC REAC:R-HSA-2132295 MHC class II antigen presentation 6.76622558656764e-09 123 25 8 0.32 0.0650406504065041
REAC REAC:R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 9.32211856686034e-09 20 22 5 0.227272727272727 0.25
REAC REAC:R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 1.88912372850088e-08 23 22 5 0.227272727272727 0.217391304347826
REAC REAC:R-HSA-389948 PD-1 signaling 2.24287165535307e-08 24 22 5 0.227272727272727 0.208333333333333
REAC REAC:R-HSA-202433 Generation of second messenger molecules 1.59407669319924e-07 35 22 5 0.227272727272727 0.142857142857143
REAC REAC:R-HSA-388841 Costimulation by the CD28 family 3.65554142324937e-06 67 9 4 0.444444444444444 0.0597014925373134
REAC REAC:R-HSA-8939902 Regulation of RUNX2 expression and activity 4.56750209526935e-06 71 40 6 0.15 0.0845070422535211
REAC REAC:R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 1.80529571608705e-05 52 40 5 0.125 0.0961538461538462
REAC REAC:R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 1.80529571608705e-05 52 40 5 0.125 0.0961538461538462
REAC REAC:R-HSA-9604323 Negative regulation of NOTCH4 signaling 1.80529571608705e-05 53 40 5 0.125 0.0943396226415094
REAC REAC:R-HSA-169911 Regulation of Apoptosis 1.80529571608705e-05 53 40 5 0.125 0.0943396226415094
REAC REAC:R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 1.80529571608705e-05 50 40 5 0.125 0.1
REAC REAC:R-HSA-180585 Vif-mediated degradation of APOBEC3G 1.80529571608705e-05 53 40 5 0.125 0.0943396226415094
REAC REAC:R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 1.80529571608705e-05 50 40 5 0.125 0.1
REAC REAC:R-HSA-69610 p53-Independent DNA Damage Response 1.80529571608705e-05 52 40 5 0.125 0.0961538461538462
REAC REAC:R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 1.80529571608705e-05 51 40 5 0.125 0.0980392156862745
REAC REAC:R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 1.80529571608705e-05 52 40 5 0.125 0.0961538461538462
REAC REAC:R-HSA-180534 Vpu mediated degradation of CD4 1.80529571608705e-05 52 40 5 0.125 0.0961538461538462
REAC REAC:R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 1.80529571608705e-05 52 40 5 0.125 0.0961538461538462
REAC REAC:R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 1.86133839307075e-05 55 40 5 0.125 0.0909090909090909
REAC REAC:R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 1.86133839307075e-05 54 40 5 0.125 0.0925925925925926
REAC REAC:R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 1.86133839307075e-05 181 23 6 0.260869565217391 0.0331491712707182
REAC REAC:R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 1.86133839307075e-05 55 40 5 0.125 0.0909090909090909
REAC REAC:R-HSA-4641257 Degradation of AXIN 1.86133839307075e-05 55 40 5 0.125 0.0909090909090909
REAC REAC:R-HSA-8941858 Regulation of RUNX3 expression and activity 1.86133839307075e-05 54 40 5 0.125 0.0925925925925926
REAC REAC:R-HSA-5362768 Hh mutants are degraded by ERAD 1.95537830570516e-05 56 40 5 0.125 0.0892857142857143
REAC REAC:R-HSA-4641258 Degradation of DVL 2.03319644873825e-05 57 40 5 0.125 0.087719298245614
REAC REAC:R-HSA-69541 Stabilization of p53 2.03319644873825e-05 57 40 5 0.125 0.087719298245614
REAC REAC:R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 2.11436924384917e-05 60 40 5 0.125 0.0833333333333333
REAC REAC:R-HSA-5676590 NIK-->noncanonical NF-kB signaling 2.11436924384917e-05 59 40 5 0.125 0.0847457627118644
REAC REAC:R-HSA-351202 Metabolism of polyamines 2.11436924384917e-05 58 40 5 0.125 0.0862068965517241
REAC REAC:R-HSA-8851680 Butyrophilin (BTN) family interactions 2.11436924384917e-05 12 91 4 0.043956043956044 0.333333333333333
REAC REAC:R-HSA-5610780 Degradation of GLI1 by the proteasome 2.11436924384917e-05 60 40 5 0.125 0.0833333333333333
REAC REAC:R-HSA-5610783 Degradation of GLI2 by the proteasome 2.11436924384917e-05 60 40 5 0.125 0.0833333333333333
REAC REAC:R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 2.11436924384917e-05 60 40 5 0.125 0.0833333333333333
REAC REAC:R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 2.11436924384917e-05 60 40 5 0.125 0.0833333333333333
REAC REAC:R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 2.11436924384917e-05 59 40 5 0.125 0.0847457627118644
REAC REAC:R-HSA-5387390 Hh mutants abrogate ligand secretion 2.11436924384917e-05 59 40 5 0.125 0.0847457627118644
REAC REAC:R-HSA-5678895 Defective CFTR causes cystic fibrosis 2.2526087563322e-05 61 40 5 0.125 0.0819672131147541
REAC REAC:R-HSA-162909 Host Interactions of HIV factors 2.70223147299298e-05 125 21 5 0.238095238095238 0.04
REAC REAC:R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 2.70690285661567e-05 64 40 5 0.125 0.078125
REAC REAC:R-HSA-4608870 Asymmetric localization of PCP proteins 2.70690285661567e-05 64 40 5 0.125 0.078125
REAC REAC:R-HSA-5358346 Hedgehog ligand biogenesis 2.87214090487667e-05 65 40 5 0.125 0.0769230769230769
REAC REAC:R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 2.94138696513044e-05 66 40 5 0.125 0.0757575757575758
REAC REAC:R-HSA-69563 p53-Dependent G1 DNA Damage Response 2.94138696513044e-05 66 40 5 0.125 0.0757575757575758
REAC REAC:R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 2.94138696513044e-05 66 40 5 0.125 0.0757575757575758
REAC REAC:R-HSA-8878166 Transcriptional regulation by RUNX2 3.01642065942206e-05 118 40 6 0.15 0.0508474576271186
REAC REAC:R-HSA-1169091 Activation of NF-kappaB in B cells 3.01642065942206e-05 67 40 5 0.125 0.0746268656716418
REAC REAC:R-HSA-5658442 Regulation of RAS by GAPs 3.01642065942206e-05 67 40 5 0.125 0.0746268656716418
REAC REAC:R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 3.09695512842396e-05 68 40 5 0.125 0.0735294117647059
REAC REAC:R-HSA-69615 G1/S DNA Damage Checkpoints 3.09695512842396e-05 68 40 5 0.125 0.0735294117647059
REAC REAC:R-HSA-68867 Assembly of the pre-replicative complex 3.09695512842396e-05 68 40 5 0.125 0.0735294117647059
REAC REAC:R-HSA-8948751 Regulation of PTEN stability and activity 3.27921403108529e-05 69 40 5 0.125 0.072463768115942
REAC REAC:R-HSA-68949 Orc1 removal from chromatin 3.72160799895067e-05 71 40 5 0.125 0.0704225352112676
REAC REAC:R-HSA-380108 Chemokine receptors bind chemokines 4.08668981110397e-05 57 135 7 0.0518518518518519 0.12280701754386
REAC REAC:R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 4.08668981110397e-05 73 40 5 0.125 0.0684931506849315
REAC REAC:R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 4.08668981110397e-05 73 40 5 0.125 0.0684931506849315
REAC REAC:R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 4.24928807360587e-05 74 40 5 0.125 0.0675675675675676
REAC REAC:R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 4.24928807360587e-05 74 40 5 0.125 0.0675675675675676
REAC REAC:R-HSA-1234174 Cellular response to hypoxia 4.47801314271766e-05 75 40 5 0.125 0.0666666666666667
REAC REAC:R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 4.5872458988899e-05 100 52 6 0.115384615384615 0.06
REAC REAC:R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 4.65263021883085e-05 76 40 5 0.125 0.0657894736842105
REAC REAC:R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 4.83307617525144e-05 77 40 5 0.125 0.0649350649350649
REAC REAC:R-HSA-5619084 ABC transporter disorders 4.83307617525144e-05 77 40 5 0.125 0.0649350649350649
REAC REAC:R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 5.41227131009581e-05 79 40 5 0.125 0.0632911392405063
REAC REAC:R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 5.68423651775045e-05 80 40 5 0.125 0.0625
REAC REAC:R-HSA-9013694 Signaling by NOTCH4 5.89226118137143e-05 81 40 5 0.125 0.0617283950617284
REAC REAC:R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 5.89226118137143e-05 81 40 5 0.125 0.0617283950617284
REAC REAC:R-HSA-69202 Cyclin E associated events during G1/S transition 6.40305230591604e-05 83 40 5 0.125 0.0602409638554217
REAC REAC:R-HSA-195253 Degradation of beta-catenin by the destruction complex 6.40305230591604e-05 83 40 5 0.125 0.0602409638554217
REAC REAC:R-HSA-168249 Innate Immune System 6.40305230591604e-05 1073 21 10 0.476190476190476 0.00931966449207828
REAC REAC:R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 6.94577870305714e-05 85 40 5 0.125 0.0588235294117647
REAC REAC:R-HSA-69002 DNA Replication Pre-Initiation 6.94577870305714e-05 85 40 5 0.125 0.0588235294117647
REAC REAC:R-HSA-5632684 Hedgehog 'on' state 6.94577870305714e-05 85 40 5 0.125 0.0588235294117647
REAC REAC:R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 7.27055097902366e-05 86 40 5 0.125 0.0581395348837209
REAC REAC:R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 7.95261973345654e-05 88 40 5 0.125 0.0568181818181818
REAC REAC:R-HSA-453276 Regulation of mitotic cell cycle 7.95261973345654e-05 88 40 5 0.125 0.0568181818181818
REAC REAC:R-HSA-5687128 MAPK6/MAPK4 signaling 8.31033316905083e-05 89 40 5 0.125 0.0561797752808989
REAC REAC:R-HSA-69052 Switching of origins to a post-replicative state 9.15864658168985e-05 91 40 5 0.125 0.0549450549450549
REAC REAC:R-HSA-4086400 PCP/CE pathway 9.45270802019694e-05 92 40 5 0.125 0.0543478260869565
REAC REAC:R-HSA-5689603 UCH proteinases 9.45270802019694e-05 92 40 5 0.125 0.0543478260869565
REAC REAC:R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.000102741000304565 94 40 5 0.125 0.0531914893617021
REAC REAC:R-HSA-8878159 Transcriptional regulation by RUNX3 0.000102741000304565 94 40 5 0.125 0.0531914893617021
REAC REAC:R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.000118393366910053 97 40 5 0.125 0.0515463917525773
REAC REAC:R-HSA-9020702 Interleukin-1 signaling 0.000142441243373795 101 40 5 0.125 0.0495049504950495
REAC REAC:R-HSA-382556 ABC-family proteins mediated transport 0.000154974097676177 103 40 5 0.125 0.0485436893203883
REAC REAC:R-HSA-5610787 Hedgehog 'off' state 0.000239278557058356 113 40 5 0.125 0.0442477876106195
REAC REAC:R-HSA-9683610 Maturation of nucleoprotein 0.000248428317842978 10 89 3 0.0337078651685393 0.3
REAC REAC:R-HSA-162906 HIV Infection 0.000248428317842978 226 21 5 0.238095238095238 0.0221238938053097
REAC REAC:R-HSA-157118 Signaling by NOTCH 0.000253579518371989 197 24 5 0.208333333333333 0.0253807106598985
REAC REAC:R-HSA-69239 Synthesis of DNA 0.000299718352127985 120 21 4 0.19047619047619 0.0333333333333333
REAC REAC:R-HSA-69306 DNA Replication 0.000381554382594412 128 21 4 0.19047619047619 0.03125
REAC REAC:R-HSA-69206 G1/S Transition 0.000413497216728008 131 21 4 0.19047619047619 0.0305343511450382
REAC REAC:R-HSA-5621481 C-type lectin receptors (CLRs) 0.000469198873124197 136 21 4 0.19047619047619 0.0294117647058824
REAC REAC:R-HSA-2871837 FCERI mediated NF-kB activation 0.000469198873124197 136 21 4 0.19047619047619 0.0294117647058824
REAC REAC:R-HSA-196807 Nicotinate metabolism 0.000487021721864988 31 92 4 0.0434782608695652 0.129032258064516
REAC REAC:R-HSA-446652 Interleukin-1 family signaling 0.000487021721864988 138 21 4 0.19047619047619 0.0289855072463768
REAC REAC:R-HSA-109581 Apoptosis 0.000487021721864988 174 49 6 0.122448979591837 0.0344827586206897
REAC REAC:R-HSA-6807070 PTEN Regulation 0.000487021721864988 138 21 4 0.19047619047619 0.0289855072463768
REAC REAC:R-HSA-5357801 Programmed Cell Death 0.000530043834808989 177 49 6 0.122448979591837 0.0338983050847458
REAC REAC:R-HSA-3858494 Beta-catenin independent WNT signaling 0.000539610290059056 143 21 4 0.19047619047619 0.027972027972028
REAC REAC:R-HSA-453279 Mitotic G1 phase and G1/S transition 0.000610664043071788 148 21 4 0.19047619047619 0.027027027027027
REAC REAC:R-HSA-5358351 Signaling by Hedgehog 0.000615984670710434 149 21 4 0.19047619047619 0.0268456375838926
REAC REAC:R-HSA-69481 G2/M Checkpoints 0.000615984670710434 149 21 4 0.19047619047619 0.0268456375838926
REAC REAC:R-HSA-8951664 Neddylation 0.000717751573402303 233 40 6 0.15 0.0257510729613734
REAC REAC:R-HSA-69242 S Phase 0.000834896373919167 162 21 4 0.19047619047619 0.0246913580246914
REAC REAC:R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.00086773458949971 164 21 4 0.19047619047619 0.024390243902439
REAC REAC:R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.000893024641095733 308 21 5 0.238095238095238 0.0162337662337662
REAC REAC:R-HSA-449147 Signaling by Interleukins 0.000993016047087905 446 42 8 0.19047619047619 0.0179372197309417
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.000993096164533696 171 21 4 0.19047619047619 0.0233918128654971
REAC REAC:R-HSA-5619115 Disorders of transmembrane transporters 0.00102973946058989 173 21 4 0.19047619047619 0.023121387283237
REAC REAC:R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.00122904308664657 182 21 4 0.19047619047619 0.021978021978022
REAC REAC:R-HSA-2467813 Separation of Sister Chromatids 0.00137899863422082 188 21 4 0.19047619047619 0.0212765957446809
REAC REAC:R-HSA-197264 Nicotinamide salvaging 0.00151297163830571 19 89 3 0.0337078651685393 0.157894736842105
REAC REAC:R-HSA-201681 TCF dependent signaling in response to WNT 0.00157719062224088 196 21 4 0.19047619047619 0.0204081632653061
REAC REAC:R-HSA-69275 G2/M Transition 0.00157719062224088 196 21 4 0.19047619047619 0.0204081632653061
REAC REAC:R-HSA-453274 Mitotic G2-G2/M phases 0.00162630539676266 198 21 4 0.19047619047619 0.0202020202020202
REAC REAC:R-HSA-8878171 Transcriptional regulation by RUNX1 0.00166374814659151 200 21 4 0.19047619047619 0.02
REAC REAC:R-HSA-5689880 Ub-specific processing proteases 0.00166374814659151 200 21 4 0.19047619047619 0.02
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 0.00222730190829495 217 21 4 0.19047619047619 0.0184331797235023
REAC REAC:R-HSA-68882 Mitotic Anaphase 0.00265987308955247 228 21 4 0.19047619047619 0.0175438596491228
REAC REAC:R-HSA-2555396 Mitotic Metaphase and Anaphase 0.00268391410131649 229 21 4 0.19047619047619 0.0174672489082969
REAC REAC:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.00352632499991936 371 24 5 0.208333333333333 0.0134770889487871
REAC REAC:R-HSA-1257604 PIP3 activates AKT signaling 0.00361059188227564 249 21 4 0.19047619047619 0.0160642570281124
REAC REAC:R-HSA-9683701 Translation of structural proteins 0.00441706580088292 28 89 3 0.0337078651685393 0.107142857142857
REAC REAC:R-HSA-5673001 RAF/MAP kinase cascade 0.00441706580088292 264 21 4 0.19047619047619 0.0151515151515152
REAC REAC:R-HSA-5684996 MAPK1/MAPK3 signaling 0.0046991908345857 269 21 4 0.19047619047619 0.0148698884758364
REAC REAC:R-HSA-69620 Cell Cycle Checkpoints 0.0047949872107715 271 21 4 0.19047619047619 0.014760147601476
REAC REAC:R-HSA-5688426 Deubiquitination 0.00506335302504183 276 21 4 0.19047619047619 0.0144927536231884
REAC REAC:R-HSA-9607240 FLT3 Signaling 0.00515665648318284 278 21 4 0.19047619047619 0.0143884892086331
REAC REAC:R-HSA-9006925 Intracellular signaling by second messengers 0.00590159812731934 289 21 4 0.19047619047619 0.013840830449827
REAC REAC:R-HSA-195721 Signaling by WNT 0.00608647603104174 292 21 4 0.19047619047619 0.0136986301369863
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 0.00620517852593789 368 40 6 0.15 0.016304347826087
REAC REAC:R-HSA-5683057 MAPK family signaling cascades 0.00728862369801189 308 21 4 0.19047619047619 0.012987012987013
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.0106441471637237 474 8 3 0.375 0.00632911392405063
REAC REAC:R-HSA-451927 Interleukin-2 family signaling 0.0114261580753921 44 81 3 0.037037037037037 0.0681818181818182
REAC REAC:R-HSA-68886 M Phase 0.0137267477365132 371 21 4 0.19047619047619 0.0107816711590297
REAC REAC:R-HSA-9678108 SARS-CoV-1 Infection 0.020538297292683 50 89 3 0.0337078651685393 0.06
REAC REAC:R-HSA-375276 Peptide ligand-binding receptors 0.0291567676529731 195 135 7 0.0518518518518519 0.0358974358974359
REAC REAC:R-HSA-6783783 Interleukin-10 signaling 0.0343315856884118 45 123 3 0.024390243902439 0.0666666666666667
REAC REAC:R-HSA-69278 Cell Cycle, Mitotic 0.0379774694665152 513 21 4 0.19047619047619 0.00779727095516569
REAC REAC:R-HSA-5663205 Infectious disease 0.0423982182747049 815 21 5 0.238095238095238 0.00613496932515337
REAC REAC:R-HSA-977606 Regulation of Complement cascade 0.0439526177765537 101 109 4 0.036697247706422 0.0396039603960396
REAC REAC:R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.0440870172804559 120 92 4 0.0434782608695652 0.0333333333333333
REAC REAC:R-HSA-2262752 Cellular responses to stress 0.0446269325179089 546 21 4 0.19047619047619 0.00732600732600733
REAC REAC:R-HSA-422475 Axon guidance 0.0451831884296367 549 21 4 0.19047619047619 0.00728597449908925
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 0.0466778901505786 560 21 4 0.19047619047619 0.00714285714285714
REAC REAC:R-HSA-9675108 Nervous system development 0.0498016292845307 574 21 4 0.19047619047619 0.00696864111498258
TF TF:M09957 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN 4.22201714108179e-29 272 116 32 0.275862068965517 0.117647058823529
TF TF:M07216 Factor: IRF1; motif: NNNYASTTTCACTTTCNNTTT 6.90098597196173e-28 440 116 36 0.310344827586207 0.0818181818181818
TF TF:M04788 Factor: IRF-1; motif: STTTCACTTTCNNT 3.95986837494792e-23 536 89 31 0.348314606741573 0.0578358208955224
TF TF:M08887 Factor: IRF; motif: NNGAAANTGAAANN 3.95986837494792e-23 1267 130 50 0.384615384615385 0.0394632991318074
TF TF:M11664 Factor: IRF-2; motif: NGAAASYGAAAS 9.72342035917312e-23 1651 116 52 0.448275862068966 0.031496062992126
TF TF:M09629 Factor: IRF-1; motif: NAAANNGAAAGTGAAASTRN 3.25493147920604e-20 336 116 27 0.232758620689655 0.0803571428571429
TF TF:M08775_1 Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 6.70504938255325e-20 2761 129 65 0.503875968992248 0.0235421948569359
TF TF:M11685 Factor: IRF-8; motif: NCGAAACYGAAACYN 1.1805248872316e-19 1617 89 42 0.471910112359551 0.025974025974026
TF TF:M11665 Factor: IRF-2; motif: NGAAASYGAAAS 4.2426096531198e-19 2396 126 59 0.468253968253968 0.0246243739565943
TF TF:M09956 Factor: IRF-1; motif: NAAANNGAAASTGAAASNRN 1.56252428874025e-18 317 116 25 0.21551724137931 0.0788643533123028
TF TF:M00772 Factor: IRF; motif: RRAANTGAAASYGNV 5.37236768560603e-18 1029 122 39 0.319672131147541 0.0379008746355685
TF TF:M11682 Factor: IRF-8; motif: NYGAAASYGAAACYN 4.03242813011298e-17 3795 93 58 0.623655913978495 0.0152832674571805
TF TF:M11686 Factor: IRF-4; motif: NYGAAASYGAAACYN 2.70230493979318e-16 3391 131 67 0.511450381679389 0.0197581834267178
TF TF:M11684 Factor: IRF-8; motif: NYGAAACYGAAACTN 6.6759287977492e-16 4664 131 78 0.595419847328244 0.0167238421955403
TF TF:M08887_1 Factor: IRF; motif: NNGAAANTGAAANN; match class: 1 3.18886754311896e-15 73 116 14 0.120689655172414 0.191780821917808
TF TF:M00453 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN 8.31106406870599e-15 3082 90 49 0.544444444444444 0.0158987670343932
TF TF:M07045 Factor: IRF-1; motif: NNRAAANNGAAASN 1.94773624226859e-14 535 126 27 0.214285714285714 0.0504672897196262
TF TF:M11677 Factor: IRF-3; motif: NGGAAACNGAAACCGAAACN 4.98342135056075e-14 470 123 25 0.203252032520325 0.0531914893617021
TF TF:M11679 Factor: IRF-7; motif: NCGAAANCGAAANYN 5.5540188442756e-14 622 87 24 0.275862068965517 0.0385852090032154
TF TF:M08775 Factor: IRF-2; motif: NAANYGAAASYR 1.33500566410538e-13 8370 129 100 0.775193798449612 0.01194743130227
TF TF:M00972 Factor: IRF; motif: RAAANTGAAAN 1.83338036535268e-13 1979 138 49 0.355072463768116 0.0247599797877716
TF TF:M11685_1 Factor: IRF-8; motif: NCGAAACYGAAACYN; match class: 1 3.17266517957213e-13 118 126 15 0.119047619047619 0.127118644067797
TF TF:M11687 Factor: IRF-4; motif: NCGAAACCGAAACYN 5.92733990666149e-13 3595 90 50 0.555555555555556 0.0139082058414465
TF TF:M09733 Factor: STAT2; motif: NRGAAANNGAAACTNA 7.4045245131213e-13 2842 116 52 0.448275862068966 0.0182969739619986
TF TF:M11683 Factor: IRF-8; motif: NCGAAACCGAAACYN 3.31773231563916e-12 4690 93 57 0.612903225806452 0.0121535181236674
TF TF:M04020 Factor: IRF8; motif: NCGAAACCGAAACT 1.19785562028075e-11 992 79 25 0.316455696202532 0.0252016129032258
TF TF:M04018 Factor: IRF7; motif: NCGAAARYGAAANT 7.23847615319414e-11 619 79 20 0.253164556962025 0.0323101777059774
TF TF:M11665_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 7.93088809545384e-11 246 126 17 0.134920634920635 0.0691056910569106
TF TF:M00453_1 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN; match class: 1 8.17480235383737e-11 332 81 16 0.197530864197531 0.0481927710843374
TF TF:M11676 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN 1.42574298527175e-10 562 123 23 0.186991869918699 0.0409252669039146
TF TF:M11670 Factor: IRF-5; motif: NYGAAACCGAAACY 2.11315746668765e-10 871 126 28 0.222222222222222 0.0321469575200918
TF TF:M11664_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 3.08872847093782e-10 140 89 12 0.134831460674157 0.0857142857142857
TF TF:M04014 Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR 3.51531243849604e-10 278 89 15 0.168539325842697 0.0539568345323741
TF TF:M04015 Factor: IRF-4; motif: NCGAAACCGAAACYA 4.4027889701654e-10 2038 79 32 0.40506329113924 0.0157016683022571
TF TF:M11684_1 Factor: IRF-8; motif: NYGAAACYGAAACTN; match class: 1 1.87399215945969e-09 832 80 21 0.2625 0.0252403846153846
TF TF:M00258 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC 1.99230157595007e-09 823 126 26 0.206349206349206 0.031591737545565
TF TF:M11682_1 Factor: IRF-8; motif: NYGAAASYGAAACYN; match class: 1 5.47693227495614e-09 543 89 18 0.202247191011236 0.0331491712707182
TF TF:M11683_1 Factor: IRF-8; motif: NCGAAACCGAAACYN; match class: 1 8.81882322076593e-09 814 116 24 0.206896551724138 0.0294840294840295
TF TF:M07323 Factor: IRF-4; motif: KRAAMNGAAANYN 1.24694468719227e-08 938 87 22 0.252873563218391 0.023454157782516
TF TF:M11686_1 Factor: IRF-4; motif: NYGAAASYGAAACYN; match class: 1 1.30540632753364e-08 452 126 19 0.150793650793651 0.0420353982300885
TF TF:M00699_1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 2.07992049209437e-08 47 105 8 0.0761904761904762 0.170212765957447
TF TF:M09733_1 Factor: STAT2; motif: NRGAAANNGAAACTNA; match class: 1 3.02843887915742e-08 367 126 17 0.134920634920635 0.0463215258855586
TF TF:M01882 Factor: IRF-2; motif: NNRAAAGTGAAASNNA 3.05400808340402e-08 258 111 14 0.126126126126126 0.0542635658914729
TF TF:M11671 Factor: IRF-5; motif: NCGAAACCGAAACY 3.05400808340402e-08 389 75 14 0.186666666666667 0.0359897172236504
TF TF:M11687_1 Factor: IRF-4; motif: NCGAAACCGAAACYN; match class: 1 1.93539374135409e-07 474 126 18 0.142857142857143 0.0379746835443038
TF TF:M00258_1 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC; match class: 1 1.93700537683801e-07 30 75 6 0.08 0.2
TF TF:M00699 Factor: ICSBP; motif: RAARTGAAACTG 2.94221424318874e-07 1184 105 25 0.238095238095238 0.0211148648648649
TF TF:M00287 Factor: NF-Y; motif: NNNRRCCAATSRGNNN 5.89585357805016e-07 1635 23 13 0.565217391304348 0.00795107033639144
TF TF:M04849_1 Factor: RelA-p65; motif: AAASTCCC; match class: 1 6.15559537674092e-07 1170 59 18 0.305084745762712 0.0153846153846154
TF TF:M04683 Factor: NF-YA; motif: YTCTSATTGGYYRN 6.66345528752083e-07 1657 23 13 0.565217391304348 0.00784550392275196
TF TF:M00972_1 Factor: IRF; motif: RAAANTGAAAN; match class: 1 1.58256475046003e-06 205 105 11 0.104761904761905 0.0536585365853659
TF TF:M00063 Factor: IRF-2; motif: GAAAAGYGAAASY 1.58256475046003e-06 685 138 21 0.152173913043478 0.0306569343065693
TF TF:M06507 Factor: ZFP90; motif: NGGGASTTTAKA 2.4041253702916e-06 40 15 4 0.266666666666667 0.1
TF TF:M00687 Factor: alpha-CP1; motif: CAGCCAATGAG 2.44829116856985e-06 2326 36 18 0.5 0.00773860705073087
TF TF:M00772_1 Factor: IRF; motif: RRAANTGAAASYGNV; match class: 1 2.50234485878791e-06 57 105 7 0.0666666666666667 0.12280701754386
TF TF:M09745_1 Factor: HELIOS; motif: RNARRRGGAASTGARAN; match class: 1 3.93635006935338e-06 495 116 16 0.137931034482759 0.0323232323232323
TF TF:M07302 Factor: NF-Y; motif: RGCCAATCRGN 4.39226079734251e-06 1576 23 12 0.521739130434783 0.00761421319796954
TF TF:M09957_1 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN; match class: 1 4.66941068217365e-06 22 89 5 0.0561797752808989 0.227272727272727
TF TF:M09745 Factor: HELIOS; motif: RNARRRGGAASTGARAN 4.83283725633499e-06 3582 134 51 0.380597014925373 0.0142378559463987
TF TF:M11680 Factor: IRF-9; motif: NYGAAACYGAAACYN 4.88170601815985e-06 128 79 8 0.10126582278481 0.0625
TF TF:M04015_1 Factor: IRF-4; motif: NCGAAACCGAAACYA; match class: 1 5.1974525440792e-06 158 26 6 0.230769230769231 0.0379746835443038
TF TF:M10080 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN 5.73360846628156e-06 356 105 13 0.123809523809524 0.0365168539325843
TF TF:M09959 Factor: IRF-4; motif: NAANGRGGAASTGAAASN 5.79880680803199e-06 3386 134 49 0.365671641791045 0.0144713526284702
TF TF:M11681 Factor: IRF-9; motif: NCGAAACYGAAACYN 8.49856484467838e-06 97 75 7 0.0933333333333333 0.0721649484536082
TF TF:M01279 Factor: IRF-3; motif: NBNBTTTCSCTTT 8.49856484467838e-06 1647 92 25 0.271739130434783 0.0151791135397693
TF TF:M03916 Factor: PRDM1; motif: NRAAAGTGAAAGTNN 1.32585117511768e-05 948 61 15 0.245901639344262 0.0158227848101266
TF TF:M10006 Factor: NF-YC; motif: NNRRCCAATCAGNR 1.54750914472339e-05 2510 24 14 0.583333333333333 0.00557768924302789
TF TF:M10005 Factor: NF-YA; motif: NYRRCCAATCAGAR 1.70730139520397e-05 2225 23 13 0.565217391304348 0.00584269662921348
TF TF:M04706 Factor: RelA; motif: GGGRAWTYC 1.74768639786544e-05 2278 81 27 0.333333333333333 0.0118525021949078
TF TF:M03882_1 Factor: RelB:p50; motif: RGAAANTCCCYNNHGC; match class: 1 2.48607219645885e-05 714 62 13 0.209677419354839 0.0182072829131653
TF TF:M03793 Factor: IRF-7; motif: AARGGAAANNGAA 2.60925973782987e-05 1987 116 31 0.267241379310345 0.015601409159537
TF TF:M09958 Factor: IRF-3; motif: RAAARGGAAANNGAAASNGA 2.83625847188221e-05 589 101 15 0.148514851485149 0.0254668930390492
TF TF:M11672 Factor: IRF-5; motif: NCGAAACCGAAACY 3.26895330365967e-05 120 75 7 0.0933333333333333 0.0583333333333333
TF TF:M09816 Factor: NFYA; motif: RRCCAATCAGN 3.96263846763425e-05 1969 23 12 0.521739130434783 0.00609446419502285
TF TF:M03916_1 Factor: PRDM1; motif: NRAAAGTGAAAGTNN; match class: 1 3.97631929992355e-05 50 61 5 0.0819672131147541 0.1
TF TF:M07216_1 Factor: IRF1; motif: NNNYASTTTCACTTTCNNTTT; match class: 1 4.1946793118454e-05 35 89 5 0.0561797752808989 0.142857142857143
TF TF:M00208_1 Factor: NF-kappaB; motif: NGGGACTTTCCA; match class: 1 4.2823333177136e-05 604 25 8 0.32 0.0132450331125828
TF TF:M03793_1 Factor: IRF-7; motif: AARGGAAANNGAA; match class: 1 4.53680151949136e-05 138 101 8 0.0792079207920792 0.0579710144927536
TF TF:M04788_1 Factor: IRF-1; motif: STTTCACTTTCNNT; match class: 1 4.53680151949136e-05 17 79 4 0.0506329113924051 0.235294117647059
TF TF:M01884 Factor: IRF-7; motif: AAGWGAA 6.03470115262041e-05 10868 117 90 0.769230769230769 0.00828119249171881
TF TF:M11678 Factor: IRF-7; motif: NNGAAAGTGAAANTR 0.000130754117367601 179 90 8 0.0888888888888889 0.0446927374301676
TF TF:M11383 Factor: ESE-1; motif: ACCAGGAAGTANNNNNNNAAWAA 0.00017755368396212 3886 139 51 0.366906474820144 0.0131240349974267
TF TF:M05989 Factor: ZNF275; motif: KGGGMCWTTAGA 0.000197286057391471 36 15 3 0.2 0.0833333333333333
TF TF:M00062 Factor: IRF-1; motif: SAAAAGYGAAACC 0.000220775807192332 576 138 16 0.115942028985507 0.0277777777777778
TF TF:M00054 Factor: NF-kappaB; motif: GGGAMTTYCC 0.000222107272891943 2444 41 17 0.414634146341463 0.00695581014729951
TF TF:M00747 Factor: IRF-1; motif: TTCACTT 0.000248032717191808 5208 117 54 0.461538461538462 0.01036866359447
TF TF:M07314 Factor: Blimp-1; motif: RGRAAGNGAAAG 0.000248032717191808 1460 93 21 0.225806451612903 0.0143835616438356
TF TF:M03557 Factor: P50; motif: GGRRANTCCCNN 0.000248496548124828 4967 63 33 0.523809523809524 0.00664384940608013
TF TF:M02106 Factor: NF-YA; motif: CRGCCAATCAGNRN 0.000295899329989728 1741 17 9 0.529411764705882 0.00516944284893739
TF TF:M00051 Factor: NF-kappaB; motif: GGGGATYCCC 0.0003115950134425 6413 26 20 0.769230769230769 0.00311866521128957
TF TF:M03557_1 Factor: P50; motif: GGRRANTCCCNN; match class: 1 0.0003115950134425 1292 39 12 0.307692307692308 0.00928792569659443
TF TF:M09668 Factor: RelA-p65; motif: GGGRNTTTCCM 0.0003115950134425 3576 110 40 0.363636363636364 0.0111856823266219
TF TF:M03882 Factor: RelB:p50; motif: RGAAANTCCCYNNHGC 0.0003115950134425 4474 55 28 0.509090909090909 0.00625838176128744
TF TF:M01884_1 Factor: IRF-7; motif: AAGWGAA; match class: 1 0.000514431825159454 4556 106 45 0.424528301886792 0.00987708516242318
TF TF:M00209 Factor: NF-Y; motif: NCTGATTGGYTASY 0.000526345952514393 3776 25 15 0.6 0.00397245762711864
TF TF:M00194_1 Factor: NF-kappaB; motif: NGGGGAMTTTCCNN; match class: 1 0.000537354555937838 385 107 11 0.102803738317757 0.0285714285714286
TF TF:M11679_1 Factor: IRF-7; motif: NCGAAANCGAAANYN; match class: 1 0.00059674824994574 23 35 3 0.0857142857142857 0.130434782608696
TF TF:M00775 Factor: NF-Y; motif: NNNNRRCCAATSR 0.000658971077082496 1428 17 8 0.470588235294118 0.00560224089635854
TF TF:M10080_1 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN; match class: 1 0.000658971077082496 11 79 3 0.0379746835443038 0.272727272727273
TF TF:M02107 Factor: NF-YC; motif: NRGCCAATYAGMGC 0.00069011037508733 1001 17 7 0.411764705882353 0.00699300699300699
TF TF:M00208 Factor: NF-kappaB; motif: NGGGACTTTCCA 0.000750749846974676 3757 53 24 0.452830188679245 0.00638807559222784
TF TF:M03545_1 Factor: c-Rel; motif: NGGGAATYTCCN; match class: 1 0.000750749846974676 1011 53 12 0.226415094339623 0.0118694362017804
TF TF:M04849 Factor: RelA-p65; motif: AAASTCCC 0.000794176610926652 6240 44 28 0.636363636363636 0.00448717948717949
TF TF:M01224 Factor: P50:RELA-P65; motif: GGANTTYCCCWN 0.000938970104945619 2329 136 34 0.25 0.0145985401459854
TF TF:M11673 Factor: IRF-5; motif: NCGAAACCGAAACY 0.00121259617738235 57 114 5 0.043859649122807 0.087719298245614
TF TF:M01066 Factor: Blimp-1; motif: NRGRAAGKGAAAGKRN 0.00127154699245078 411 111 11 0.0990990990990991 0.0267639902676399
TF TF:M01883_1 Factor: IRF-4; motif: GAAARTA; match class: 1 0.00158833299068059 2948 94 30 0.319148936170213 0.0101763907734057
TF TF:M00774_1 Factor: NF-kappaB; motif: NGGGANTTYCCMNNNN; match class: 1 0.00182264185312236 192 19 4 0.210526315789474 0.0208333333333333
TF TF:M04020_1 Factor: IRF8; motif: NCGAAACCGAAACT; match class: 1 0.00188179681442902 45 79 4 0.0506329113924051 0.0888888888888889
TF TF:M04016 Factor: IRF5; motif: CCGAAACCGAAACY 0.00190193835583645 314 125 10 0.08 0.0318471337579618
TF TF:M01223_1 Factor: P50:P50; motif: NRGGGAMTNCCCN; match class: 1 0.00196029777382715 161 23 4 0.173913043478261 0.0248447204968944
TF TF:M00155 Factor: ARP-1; motif: TGARCCYTTGAMCCCW 0.00196029777382715 5581 38 23 0.605263157894737 0.00412112524637162
TF TF:M01665_1 Factor: IRF-8; motif: AGTTTCW; match class: 1 0.00227605453456789 721 122 15 0.122950819672131 0.0208044382801664
TF TF:M08895 Factor: PITX; motif: TAATCCCN 0.00305002774453606 854 17 6 0.352941176470588 0.00702576112412178
TF TF:M00051_1 Factor: NF-kappaB; motif: GGGGATYCCC; match class: 1 0.00315243311124505 2797 25 12 0.48 0.00429031104755095
TF TF:M04054_1 Factor: NF-kappaB; motif: AGGGGAWTCCCCT; match class: 1 0.00383803163685216 1295 23 8 0.347826086956522 0.00617760617760618
TF TF:M11807 Factor: RAR-gamma; motif: RAGGTCATGACCTY 0.00400487533215996 2046 132 29 0.21969696969697 0.0141739980449658
TF TF:M03563 Factor: RelA-p65; motif: GGGANTTTCCNN 0.00447303334329128 4643 139 53 0.381294964028777 0.0114150333835882
TF TF:M00747_1 Factor: IRF-1; motif: TTCACTT; match class: 1 0.00453410122979223 933 113 16 0.141592920353982 0.0171489817792069
TF TF:M10963 Factor: RHOXF1; motif: NGGATCAN 0.00485097930843662 2641 66 21 0.318181818181818 0.00795153351003408
TF TF:M10004 Factor: NF-kappaB2; motif: GGGRAANYCCC 0.00489818994686276 1073 110 17 0.154545454545455 0.0158434296365331
TF TF:M11674 Factor: IRF-3; motif: GCNGTTTCCWGGAAACNGAAAC 0.00492648447276117 4623 55 26 0.472727272727273 0.00562405364481938
TF TF:M11800_1 Factor: NR1B2; motif: RAGGTCRTGACCTY; match class: 1 0.00495011588554227 987 23 7 0.304347826086957 0.00709219858156028
TF TF:M01260_1 Factor: STAT1; motif: NNTTTCYNGGAARNNNNNNNNN; match class: 1 0.00500705736681396 657 128 14 0.109375 0.0213089802130898
TF TF:M03547 Factor: ER-alpha; motif: TGACCYN 0.00507661188516162 4712 43 22 0.511627906976744 0.00466893039049236
TF TF:M07222 Factor: NFYA; motif: AGNSYKCTGATTGGTNNR 0.00519477161857941 714 22 6 0.272727272727273 0.00840336134453781
TF TF:M00621 Factor: C/EBPdelta; motif: MATTKCNTMAYY 0.0058606406080659 3888 68 27 0.397058823529412 0.00694444444444444
TF TF:M09839 Factor: ATF4; motif: ATTGCATCAT 0.00707744444057751 2145 4 4 1 0.00186480186480186
TF TF:M05528 Factor: ZAC; motif: KGWTGGGSAT 0.00707744444057751 147 14 3 0.214285714285714 0.0204081632653061
TF TF:M09652 Factor: rfx5; motif: STCNNCWGTTGCYRGGNNRA 0.00771308876854271 981 91 14 0.153846153846154 0.0142711518858308
TF TF:M11803_1 Factor: NR1B2; motif: RAGGTCATGACCTN; match class: 1 0.00783601694417448 915 19 6 0.315789473684211 0.00655737704918033
TF TF:M10526 Factor: Blimp-1; motif: RRGNGAAAGNRANNN 0.00790562503969781 2327 61 18 0.295081967213115 0.00773528147829824
TF TF:M08359 Factor: HOXD12:Elk-1; motif: NRNCGGAAGTCGTAAAN 0.00854968123288167 6152 88 44 0.5 0.00715214564369311
TF TF:M07045_1 Factor: IRF-1; motif: NNRAAANNGAAASN; match class: 1 0.00856343646692278 19 116 3 0.0258620689655172 0.157894736842105
TF TF:M10526_1 Factor: Blimp-1; motif: RRGNGAAAGNRANNN; match class: 1 0.00856343646692278 286 137 9 0.0656934306569343 0.0314685314685315
TF TF:M07355 Factor: GR; motif: AGAACAN 0.00856343646692278 5862 105 49 0.466666666666667 0.00835892186966906
TF TF:M05548 Factor: PLAGL2; motif: AAGGACC 0.00911695661663607 4194 15 10 0.666666666666667 0.00238435860753457
TF TF:M01653_1 Factor: HMGIY; motif: NGWWATTN; match class: 1 0.00911695661663607 1496 35 10 0.285714285714286 0.00668449197860963
TF TF:M04756_1 Factor: sin3A; motif: TGTCCNNGGTGCTG; match class: 1 0.00920040204642112 7714 25 19 0.76 0.00246305418719212
TF TF:M01728_1 Factor: EAR2; motif: YGNNCTTTGNCCTK; match class: 1 0.00927253848338919 1256 10 5 0.5 0.00398089171974522
TF TF:M07314_1 Factor: Blimp-1; motif: RGRAAGNGAAAG; match class: 1 0.0100089418404849 118 91 5 0.0549450549450549 0.0423728813559322
TF TF:M10046 Factor: c-Rel; motif: NRNRGGGRAATKCCA 0.0101854360486966 4696 139 52 0.37410071942446 0.0110732538330494
TF TF:M00774 Factor: NF-kappaB; motif: NGGGANTTYCCMNNNN 0.010218672292292 1818 41 12 0.292682926829268 0.0066006600660066
TF TF:M06132 Factor: ZNF823; motif: NYYACCAGCCCT 0.010218672292292 55 107 4 0.0373831775700935 0.0727272727272727
TF TF:M09589_1 Factor: AR; motif: NGNACANNNTGTTCYNN; match class: 1 0.0106720851686209 1159 11 5 0.454545454545455 0.00431406384814495
TF TF:M10094 Factor: RelA-p65; motif: NWGGGRATTTCCMN 0.010851090554504 2429 41 14 0.341463414634146 0.00576368876080692
TF TF:M11908_1 Factor: POU3F2; motif: TAATKAGNNNNTAATKA; match class: 1 0.0111200243446727 1278 101 17 0.168316831683168 0.013302034428795
TF TF:M01718 Factor: NFATc1; motif: TTTCCWN 0.0111654989129912 5943 14 11 0.785714285714286 0.00185091704526334
TF TF:M00302 Factor: NFAT; motif: NANWGGAAAANN 0.0111654989129912 805 102 13 0.127450980392157 0.0161490683229814
TF TF:M01151 Factor: DMRT7; motif: TTGTTACAWTKTKG 0.0111654989129912 1009 127 17 0.133858267716535 0.0168483647175421
TF TF:M00240_1 Factor: Nkx2-5; motif: TYAAGTG; match class: 1 0.0111654989129912 877 132 16 0.121212121212121 0.0182440136830103
TF TF:M11853 Factor: RORgamma; motif: TAGGTCRTGACCTA 0.0113967756525862 159 16 3 0.1875 0.0188679245283019
TF TF:M11817_1 Factor: T3R-beta; motif: NRRGGTCRTGACCYYN; match class: 1 0.0117394695976773 1566 132 23 0.174242424242424 0.0146871008939974
TF TF:M01203_1 Factor: SPI1; motif: NNAAWGNGGAASTNNNN; match class: 1 0.0117634533033348 211 30 4 0.133333333333333 0.018957345971564
TF TF:M01197 Factor: Elf5; motif: WNAAGGAARTW 0.0117634533033348 2095 139 29 0.20863309352518 0.0138424821002387
TF TF:M02112 Factor: OC-2; motif: TCAATA 0.0117842672701313 7568 35 24 0.685714285714286 0.00317124735729387
TF TF:M07221 Factor: NF-kappaB1; motif: KGGRNTTTCCM 0.0117842672701313 2417 139 32 0.23021582733813 0.0132395531650807
TF TF:M00053 Factor: c-Rel; motif: SGGRNTTTCC 0.0120917430654788 3672 53 21 0.39622641509434 0.00571895424836601
TF TF:M10003 Factor: NF-kappaB1; motif: AGGGAAAK 0.0121884559500123 1983 140 28 0.2 0.0141200201714574
TF TF:M11807_1 Factor: RAR-gamma; motif: RAGGTCATGACCTY; match class: 1 0.0122516310135269 651 19 5 0.263157894736842 0.00768049155145929
TF TF:M00790_1 Factor: HNF-1; motif: WRGTTAATNATTAACNNN; match class: 1 0.0122516310135269 372 49 6 0.122448979591837 0.0161290322580645
TF TF:M01388 Factor: Dlx-5; motif: NNRGYAATTRNYKNNN 0.0130544041257247 7668 106 59 0.556603773584906 0.0076943140323422
TF TF:M09933_1 Factor: FOXP1; motif: TNTGTTTMY; match class: 1 0.0130544041257247 634 115 12 0.104347826086957 0.0189274447949527
TF TF:M12068 Factor: ZNF32; motif: NNGTAACNYGAYACC 0.0132626559259519 567 93 10 0.10752688172043 0.017636684303351
TF TF:M10046_1 Factor: c-Rel; motif: NRNRGGGRAATKCCA; match class: 1 0.0138835407357326 734 48 8 0.166666666666667 0.0108991825613079
TF TF:M09960 Factor: IRF-8; motif: NNAARRGGAASTGAAASTNN 0.0138835407357326 282 66 6 0.0909090909090909 0.0212765957446809
TF TF:M01665 Factor: IRF-8; motif: AGTTTCW 0.0145676437169706 4771 133 50 0.37593984962406 0.0104799832320268
TF TF:M11378 Factor: ESE-1; motif: ACMAGGAAGTANNNNNNNWWAWW 0.0150660993609765 3049 109 31 0.284403669724771 0.0101672679567071
TF TF:M04354_1 Factor: HOXC11; motif: NGYMATAAAAN; match class: 1 0.0150660993609765 339 129 9 0.0697674418604651 0.0265486725663717
TF TF:M11670_1 Factor: IRF-5; motif: NYGAAACCGAAACY; match class: 1 0.015182282545975 36 79 3 0.0379746835443038 0.0833333333333333
TF TF:M10126 Factor: ZNF134; motif: GCCTNNNCTMATCAGKTGAAGG 0.0155108237458609 223 119 7 0.0588235294117647 0.031390134529148
TF TF:M04054 Factor: NF-kappaB; motif: AGGGGAWTCCCCT 0.0164263110744189 2924 25 11 0.44 0.00376196990424077
TF TF:M10848 Factor: HOXB13; motif: NCCAATAAAAC 0.018002743654089 102 30 3 0.1 0.0294117647058824
TF TF:M10841 Factor: HOXC13; motif: NCCAATAAAAC 0.018002743654089 102 30 3 0.1 0.0294117647058824
TF TF:M10079_1 Factor: STAT1; motif: NCCNTTTCCNGGAAANCNC; match class: 1 0.0190120024828658 1164 128 18 0.140625 0.0154639175257732
TF TF:M07323_1 Factor: IRF-4; motif: KRAAMNGAAANYN; match class: 1 0.0191055704356127 39 80 3 0.0375 0.0769230769230769
TF TF:M11741_1 Factor: COUP-TF1; motif: RRGGTCRNTGACCYY; match class: 1 0.0191517784657492 1014 29 7 0.241379310344828 0.00690335305719921
TF TF:M11777 Factor: RXR-gamma; motif: NRGGTCAYGACCYN 0.0191517784657492 138 23 3 0.130434782608696 0.0217391304347826
TF TF:M08774 Factor: HOXD4; motif: NNYMATTANN 0.0192565606002649 4001 90 32 0.355555555555556 0.00799800049987503
TF TF:M06142 Factor: ZNF708; motif: GGAAAGTARA 0.0202598309838098 164 46 4 0.0869565217391304 0.024390243902439
TF TF:M00054_1 Factor: NF-kappaB; motif: GGGAMTTYCC; match class: 1 0.0205413430727011 712 53 8 0.150943396226415 0.0112359550561798
TF TF:M01356 Factor: PMX2B; motif: NNNAATTAATTAANNNG 0.0206416073142583 3215 106 31 0.292452830188679 0.00964230171073095
TF TF:M12334 Factor: ZBTB20; motif: NNAAYGTATRKN 0.0207723279446488 1214 94 15 0.159574468085106 0.0123558484349259
TF TF:M11783 Factor: RXR-beta; motif: RRGGTCATGACCYY 0.0209912238616643 144 23 3 0.130434782608696 0.0208333333333333
TF TF:M09899 Factor: ehf; motif: NNANSAGGAAGTNNN 0.0213720404359395 457 82 8 0.0975609756097561 0.0175054704595186
TF TF:M08359_1 Factor: HOXD12:Elk-1; motif: NRNCGGAAGTCGTAAAN; match class: 1 0.0213720404359395 1166 88 14 0.159090909090909 0.0120068610634648
TF TF:M09629_1 Factor: IRF-1; motif: NAAANNGAAAGTGAAASTRN; match class: 1 0.0219607253629208 29 116 3 0.0258620689655172 0.103448275862069
TF TF:M04017 Factor: IRF5; motif: NACCGAAACYA 0.0219607253629208 195 70 5 0.0714285714285714 0.0256410256410256
TF TF:M04013 Factor: HSFY1; motif: TTCGAANSRTTCGAA 0.022065589825898 962 23 6 0.260869565217391 0.00623700623700624
TF TF:M08302_1 Factor: FOXO1A:Net; motif: RWMAACAGGAAGTN; match class: 1 0.0223046386287566 2779 53 17 0.320754716981132 0.0061173083843109
TF TF:M09663_1 Factor: STAT1; motif: YCMTTTCCNGGAAAWCNCATNN; match class: 1 0.0223046386287566 554 53 7 0.132075471698113 0.0126353790613718
TF TF:M04279 Factor: ALX3; motif: NNYAATTANN 0.0225789804189304 3934 100 34 0.34 0.00864260294865277
TF TF:M04055 Factor: NFKB2; motif: NGGGGAWTCCCCN 0.0227074029888114 55 62 3 0.0483870967741935 0.0545454545454545
TF TF:M04055_1 Factor: NFKB2; motif: NGGGGAWTCCCCN; match class: 1 0.0227074029888114 55 62 3 0.0483870967741935 0.0545454545454545
TF TF:M04731 Factor: Blimp-1; motif: NACTTTCAC 0.0237328458602237 3997 114 38 0.333333333333333 0.00950713034776082
TF TF:M12207 Factor: GATA-4; motif: NNGATAASNN 0.0237328458602237 2844 95 26 0.273684210526316 0.00914205344585091
TF TF:M01379 Factor: HNF-1alpha; motif: NNKNNGTTAACTAANNN 0.0241489458185346 3368 6 5 0.833333333333333 0.00148456057007126
TF TF:M08957_1 Factor: NURR1:RXR-ALPHA; motif: NRGGTCRTTGACCYN; match class: 1 0.0246179345379357 3226 39 15 0.384615384615385 0.004649721016739
TF TF:M04450_1 Factor: VSX1; motif: NGCYAATTRNN; match class: 1 0.0249660867724284 3267 106 31 0.292452830188679 0.00948882767064585
TF TF:M02116_1 Factor: Sox-10; motif: NACAAWG; match class: 1 0.0249753837766241 8039 94 54 0.574468085106383 0.00671725338972509
TF TF:M11974 Factor: rfx5; motif: NYRGCAACSGTTGCYAN 0.025210069798962 629 14 4 0.285714285714286 0.00635930047694754
TF TF:M02117 Factor: STAT4; motif: TTMNNRGAAA 0.025210069798962 1353 53 11 0.207547169811321 0.00813008130081301
TF TF:M10843 Factor: HOXD13; motif: NSYAATAAAAN 0.0255437213656835 968 73 11 0.150684931506849 0.0113636363636364
TF TF:M09813_1 Factor: MYB; motif: NNCAACTGNN; match class: 1 0.0255437213656835 979 32 7 0.21875 0.00715015321756895
TF TF:M00746 Factor: Elf-1; motif: RNWMBAGGAART 0.0255437213656835 3365 27 12 0.444444444444444 0.00356612184249629
TF TF:M11676_1 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN; match class: 1 0.0258096391535786 41 89 3 0.0337078651685393 0.0731707317073171
TF TF:M00638 Factor: HNF4alpha; motif: VTGAACTTTGMMB 0.0260393734932712 2814 58 18 0.310344827586207 0.00639658848614072
TF TF:M09903 Factor: elf5; motif: NNNANSAGGAAGTNN 0.0260393734932712 1243 41 9 0.219512195121951 0.00724054706355591
TF TF:M10832 Factor: HOXA13; motif: NCCAATAAAAN 0.0266256537199694 679 73 9 0.123287671232877 0.0132547864506627
TF TF:M09589 Factor: AR; motif: NGNACANNNTGTTCYNN 0.0267470236077955 5130 17 11 0.647058823529412 0.00214424951267057
TF TF:M00412 Factor: AREB6; motif: NNYNYACCTGWVT 0.0267470236077955 4738 105 40 0.380952380952381 0.00844238075137189
TF TF:M07204 Factor: AR; motif: ARGAACANNNTGTNC 0.0267470236077955 4906 47 22 0.468085106382979 0.00448430493273543
TF TF:M04903 Factor: HNF-4alpha; motif: AGTCCAAR 0.0267470236077955 6987 23 16 0.695652173913043 0.0022899670817232
TF TF:M11765_1 Factor: TR2; motif: NRGGTCRYGACCYN; match class: 1 0.0268913574359263 1431 23 7 0.304347826086957 0.00489168413696716
TF TF:M05946_1 Factor: PRDM16; motif: KGGTCATRACCM; match class: 1 0.0275852409977403 2282 24 9 0.375 0.00394390885188431
TF TF:M07229_1 Factor: STAT3; motif: NTTCYKGGAAN; match class: 1 0.0277361285690379 969 122 15 0.122950819672131 0.0154798761609907
TF TF:M00158 Factor: COUP-TF,; motif: TGAMCTTTGMMCYT 0.0281915974310228 2215 116 25 0.21551724137931 0.0112866817155756
TF TF:M04498_1 Factor: VDR; motif: GRGTTCATYGRGTTCA; match class: 1 0.0286088096861393 876 11 4 0.363636363636364 0.0045662100456621
TF TF:M01362 Factor: CART1; motif: NGNNYTAATTARTNNNN 0.029089544034154 4558 106 39 0.367924528301887 0.00855638437911365
TF TF:M08817_1 Factor: HOXD13; motif: WNNAATAAWAY; match class: 1 0.0292188643082282 1646 105 19 0.180952380952381 0.011543134872418
TF TF:M04327_1 Factor: GSX1; motif: NNYMATTANN; match class: 1 0.0293458470298593 5540 106 45 0.424528301886792 0.00812274368231047
TF TF:M07066 Factor: STAT6; motif: TTCYYNGGAAN 0.0296325038007278 1849 35 10 0.285714285714286 0.00540832882639264
TF TF:M04611_1 Factor: FOXM1; motif: NAGASTGATTA; match class: 1 0.0296325038007278 3507 131 38 0.290076335877863 0.0108354719133162
TF TF:M11895_1 Factor: Oct-2; motif: NTATGCGCATAN; match class: 1 0.0297772748903679 1376 88 15 0.170454545454545 0.0109011627906977
TF TF:M00459_1 Factor: STAT5B; motif: NAWTTCYNGGAAWTN; match class: 1 0.0299699072277418 1896 128 24 0.1875 0.0126582278481013
TF TF:M12067 Factor: ZNF32; motif: NYGTAACNYGAYACC 0.0300184801416989 164 93 5 0.0537634408602151 0.0304878048780488
TF TF:M04249_1 Factor: FOXJ3; motif: RTAAACAA; match class: 1 0.0303595377670342 603 138 12 0.0869565217391304 0.0199004975124378
TF TF:M01043_1 Factor: CSX; motif: TSYCACTTSM; match class: 1 0.0303595377670342 1199 71 12 0.169014084507042 0.0100083402835696
TF TF:M07308 Factor: Sox-2; motif: NNNANAACAAWGRNN 0.0320175865125575 2054 67 16 0.238805970149254 0.00778967867575463
TF TF:M04468 Factor: HNF4A; motif: RRGTCCAAAGGTCAN 0.032145395889171 1186 113 16 0.141592920353982 0.0134907251264755
TF TF:M00070 Factor: Tal-1beta:ITF-2; motif: NNNAACAGATGKTNNN 0.032145395889171 1763 92 18 0.195652173913043 0.0102098695405559
TF TF:M00052 Factor: NF-kappaB; motif: GGGRATTTCC 0.0323246796869833 1874 41 11 0.268292682926829 0.00586979722518677
TF TF:M01000 Factor: AIRE; motif: GGTTATTAATTGGTTATATTGGTTD 0.0323454157904544 309 133 8 0.0601503759398496 0.0258899676375405
TF TF:M10058_1 Factor: Six-2; motif: KGAAAYNTGAKMC; match class: 1 0.0323644079349178 75 122 4 0.0327868852459016 0.0533333333333333
TF TF:M00974 Factor: SMAD; motif: TNGNCAGACWN 0.0324564908802036 4535 64 26 0.40625 0.00573318632855568
TF TF:M02271 Factor: HOXA5; motif: CDBWAATK 0.0324564908802036 1928 46 12 0.260869565217391 0.00622406639004149
TF TF:M07988 Factor: EMX1; motif: NNTAATKANN 0.0330969974587895 3512 106 32 0.30188679245283 0.00911161731207289
TF TF:M02086_1 Factor: Cdx-1; motif: TTTATK; match class: 1 0.0336533676151169 9742 95 62 0.652631578947368 0.0063641962636009
TF TF:M00194 Factor: NF-kappaB; motif: NGGGGAMTTTCCNN 0.0337716891311758 2412 53 15 0.283018867924528 0.00621890547263682
TF TF:M01223 Factor: P50:P50; motif: NRGGGAMTNCCCN 0.0337716891311758 1283 136 19 0.139705882352941 0.014809041309431
TF TF:M01388_1 Factor: Dlx-5; motif: NNRGYAATTRNYKNNN; match class: 1 0.0337716891311758 5764 106 46 0.433962264150943 0.00798056904927134
TF TF:M04197 Factor: ATF4; motif: NNATGAYGCAATM 0.0341119302728259 2164 3 3 1 0.00138632162661738
TF TF:M07614 Factor: Sox-4; motif: ACAAWGNRNYN 0.0342234823660491 1860 48 12 0.25 0.00645161290322581
TF TF:M05467 Factor: Sall1; motif: NGGTCCKRGKRA 0.0369704338721174 4211 52 21 0.403846153846154 0.00498693896936595
TF TF:M01308_1 Factor: Sox-4; motif: AACAAWGR; match class: 1 0.037110015839733 107 90 4 0.0444444444444444 0.0373831775700935
TF TF:M01124_1 Factor: Oct-4; motif: ATTGWSWTGCWAAWN; match class: 1 0.037110015839733 1757 94 18 0.191489361702128 0.0102447353443369
TF TF:M02016 Factor: HNF-4alpha; motif: GNNCAAAGKYCANNN 0.0371603312326913 2384 20 8 0.4 0.00335570469798658
TF TF:M11674_1 Factor: IRF-3; motif: GCNGTTTCCWGGAAACNGAAAC; match class: 1 0.0371603312326913 1663 140 23 0.164285714285714 0.0138304269392664
TF TF:M01010_1 Factor: HMGIY; motif: NNKKNAWTTTNYTNN; match class: 1 0.0385040862280182 3147 86 25 0.290697674418605 0.00794407372100413
TF TF:M04306 Factor: DPRX; motif: NNGGATTANN 0.0385040862280182 4886 95 37 0.389473684210526 0.00757265656979124
TF TF:M10637 Factor: Nkx2-3; motif: NSCACTTNNC 0.0385040862280182 1906 67 15 0.223880597014925 0.00786988457502623
TF TF:M04319 Factor: ESX1; motif: NNYAATTANN 0.0389715111248335 3081 102 28 0.274509803921569 0.00908795845504706
TF TF:M11015 Factor: ISL2; motif: SCACTTAN 0.0389715111248335 4207 36 16 0.444444444444444 0.00380318516757785
TF TF:M10687 Factor: HOXB7; motif: NGTAATTANN 0.0395787434428322 942 106 13 0.122641509433962 0.0138004246284501
TF TF:M01003_1 Factor: Helios; motif: NNTWGGGANNN; match class: 1 0.0395787434428322 420 103 8 0.0776699029126214 0.019047619047619
TF TF:M00083 Factor: MZF-1; motif: NGNGGGGA 0.0401871080506536 2867 125 31 0.248 0.0108126961981165
TF TF:M00346 Factor: GATA-1; motif: NCWGATAACA 0.0401871080506536 4376 109 38 0.348623853211009 0.00868372943327239
TF TF:M07432 Factor: Sox-2; motif: NNNNNAACAAWGN 0.0401871080506536 1541 134 21 0.156716417910448 0.0136275146009085
TF TF:M04299 Factor: Dlx-1; motif: NNTAATTANN 0.0405235248771398 2524 47 14 0.297872340425532 0.00554675118858954
TF TF:M07044_1 Factor: HNF-1alpha; motif: NGNNAAWNATTAACNN; match class: 1 0.0409564335906994 147 115 5 0.0434782608695652 0.0340136054421769
TF TF:M00432 Factor: TTF1; motif: ASTCAAGTRK 0.0414160728066292 5394 132 52 0.393939393939394 0.0096403411197627
TF TF:M00622 Factor: C/EBPgamma; motif: YTBATTTCARAAW 0.041850891938346 6887 130 62 0.476923076923077 0.00900246841875998
TF TF:M01733 Factor: MZF-1; motif: TGGGGAR 0.0429073100315658 11391 24 21 0.875 0.00184356070582038
TF TF:M08899_1 Factor: SOX; motif: NNNNCWTTGTT; match class: 1 0.0441530716473 154 67 4 0.0597014925373134 0.025974025974026
TF TF:M09959_1 Factor: IRF-4; motif: NAANGRGGAASTGAAASN; match class: 1 0.0441530716473 395 138 9 0.0652173913043478 0.0227848101265823
TF TF:M02013_1 Factor: HNF-1alpha; motif: RGTTAATNWTT; match class: 1 0.0443712120991379 90 115 4 0.0347826086956522 0.0444444444444444
TF TF:M09630 Factor: IRF-4; motif: RRRGRGGAASTGARAS 0.0443712120991379 954 28 6 0.214285714285714 0.00628930817610063
TF TF:M11800 Factor: NR1B2; motif: RAGGTCRTGACCTY 0.0443712120991379 3716 132 39 0.295454545454545 0.0104951560818084
TF TF:M02096 Factor: ipf1; motif: YTAATGN 0.0443770522944996 2033 46 12 0.260869565217391 0.0059026069847516
TF TF:M00957_1 Factor: PR; motif: NNNNNNRGNACNNKNTGTTCTNNNNNN; match class: 1 0.0443770522944996 559 80 8 0.1 0.0143112701252236
TF TF:M00634_1 Factor: GCM; motif: CNNRCCCGCATD; match class: 1 0.0447203261069871 145 72 4 0.0555555555555556 0.0275862068965517
TF TF:M03563_1 Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 1 0.0447203261069871 876 41 7 0.170731707317073 0.00799086757990868
TF TF:M01808_1 Factor: NMYC; motif: CAYCTG; match class: 1 0.0447203261069871 6149 73 35 0.479452054794521 0.00569198243616848
TF TF:M01043 Factor: CSX; motif: TSYCACTTSM 0.0447203261069871 6282 33 19 0.575757575757576 0.00302451448583254
TF TF:M11267 Factor: c-Jun; motif: NATGACKCATN 0.0447203261069871 3183 124 33 0.266129032258065 0.0103675777568332
TF TF:M09649 Factor: Blimp-1; motif: RAAAGTGAAAGTNN 0.0447203261069871 300 116 7 0.0603448275862069 0.0233333333333333
TF TF:M07338 Factor: Sox-10; motif: ACAAWGNN 0.0447203261069871 1695 92 17 0.184782608695652 0.0100294985250737
TF TF:M04327 Factor: GSX1; motif: NNYMATTANN 0.0448291115975532 5709 106 45 0.424528301886792 0.00788229111928534
TF TF:M10535_1 Factor: znf136; motif: CAAGAATWCTATAYCCAG; match class: 1 0.0457401908493568 2585 111 26 0.234234234234234 0.0100580270793037
TF TF:M09784 Factor: RELB; motif: NNATTCCCCNN 0.0463408951031356 5356 140 54 0.385714285714286 0.0100821508588499
TF TF:M04197_1 Factor: ATF4; motif: NNATGAYGCAATM; match class: 1 0.0463408951031356 197 90 5 0.0555555555555556 0.0253807106598985
TF TF:M11988 Factor: NFATc3; motif: NTTTCCRYGGAAAN 0.0463907073931982 7175 53 30 0.566037735849057 0.00418118466898955
TF TF:M09663 Factor: STAT1; motif: YCMTTTCCNGGAAAWCNCATNN 0.046771218763942 2762 137 32 0.233576642335766 0.0115858073859522
TF TF:M04349 Factor: HOXB5; motif: NNYMATTANN 0.046771218763942 5728 106 45 0.424528301886792 0.00785614525139665
TF TF:M11012 Factor: islet1; motif: SCAMTTAN 0.046771218763942 6170 36 20 0.555555555555556 0.00324149108589951
TF TF:M01393_1 Factor: Msx-2; motif: NNNGACYAATTAGYNNT; match class: 1 0.046771218763942 3967 86 29 0.337209302325581 0.00731031005797832
TF TF:M08199_1 Factor: ATF-4:TEF; motif: GGMTGATGCAATM; match class: 1 0.046771218763942 119 90 4 0.0444444444444444 0.0336134453781513
TF TF:M11816 Factor: T3R-beta; motif: NRGGTCAAAGGTCAN 0.0471925565501656 11742 46 37 0.804347826086957 0.00315108158746381
TF TF:M03852_1 Factor: SREBP-2; motif: NTCACCYNNNN; match class: 1 0.0471925565501656 2246 27 9 0.333333333333333 0.00400712377560107
TF TF:M03849_1 Factor: Sox-4; motif: AACAAA; match class: 1 0.0475368805721929 9090 42 29 0.69047619047619 0.00319031903190319
TF TF:M07417 Factor: Elf-1; motif: NNCAGGAAGNNN 0.0475368805721929 1774 67 14 0.208955223880597 0.00789177001127396
TF TF:M07429_1 Factor: SMAD3; motif: CAGACAS; match class: 1 0.0482105034769509 1381 9 4 0.444444444444444 0.00289645184648805
TF TF:M10082 Factor: STAT4; motif: YTTCYYNGMAN 0.0484262557755798 882 53 8 0.150943396226415 0.0090702947845805
TF TF:M11383_1 Factor: ESE-1; motif: ACCAGGAAGTANNNNNNNAAWAA; match class: 1 0.0484262557755798 589 96 9 0.09375 0.0152801358234295
TF TF:M10042_1 Factor: PR; motif: RGNACATTYTGTNCTN; match class: 1 0.0484262557755798 998 6 3 0.5 0.0030060120240481
TF TF:M00185 Factor: NF-Y; motif: TRRCCAATSRN 0.0486994014882776 870 22 5 0.227272727272727 0.00574712643678161
TF TF:M01107_1 Factor: RUSH-1alpha; motif: NNMCWTNKNN; match class: 1 0.0489726533254626 385 119 8 0.0672268907563025 0.0207792207792208
TF TF:M11638_1 Factor: Sox-4; motif: NAACAAAGRN; match class: 1 0.049087592856837 296 90 6 0.0666666666666667 0.0202702702702703
TF TF:M11317 Factor: C/EBPbeta; motif: NRTTGCGYAAYN 0.0496163994758783 4365 4 4 1 0.000916380297823597
TF TF:M07228_1 Factor: STAT1; motif: NTTCYRGGAAA; match class: 1 0.0496163994758783 99 53 3 0.0566037735849057 0.0303030303030303
TF TF:M09933 Factor: FOXP1; motif: TNTGTTTMY 0.0499554783794588 4164 72 26 0.361111111111111 0.00624399615754083
TF TF:M08190 Factor: AR; motif: GGAACGGWACATGTTCT 0.0499582452403379 7865 93 51 0.548387096774194 0.00648442466624285
TF TF:M12156_1 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN; match class: 1 0.0499582452403379 1002 28 6 0.214285714285714 0.00598802395209581
WP WP:WP2328 Allograft Rejection 1.15593869382335e-19 88 31 15 0.483870967741935 0.170454545454545
WP WP:WP4217 Ebola Virus Pathway on Host 3.35572703742993e-19 130 25 15 0.6 0.115384615384615
WP WP:WP183 Proteasome Degradation 5.0081709591421e-12 64 23 9 0.391304347826087 0.140625
WP WP:WP619 Type II interferon signaling (IFNG) 1.47971580064131e-11 37 66 10 0.151515151515152 0.27027027027027
WP WP:WP4197 The human immune response to tuberculosis 3.0749759114202e-06 23 79 6 0.0759493670886076 0.260869565217391
WP WP:WP5039 SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response 0.000346206874071133 68 123 8 0.0650406504065041 0.117647058823529
WP WP:WP4877 Host-pathogen interaction of human corona viruses - MAPK signaling 0.00490659944626974 36 27 3 0.111111111111111 0.0833333333333333
WP WP:WP558 Complement and Coagulation Cascades 0.0209401345490946 59 109 5 0.0458715596330275 0.0847457627118644
WP WP:WP75 Toll-like Receptor Signaling Pathway 0.0209401345490946 104 123 7 0.0569105691056911 0.0673076923076923
WP WP:WP2806 Human Complement System 0.0346330772550996 99 109 6 0.055045871559633 0.0606060606060606
WP WP:WP545 Complement Activation 0.0403852443230244 22 109 3 0.0275229357798165 0.136363636363636

pEpiTd19 transcription factor target enrichment of top program genes

TF enrichment of pEpiTd19
Possible regulators of activation of pEpiTd19 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.