pB09 program activity among B cells

Activation of pB09
pB09 gene program activation in B cells.
Gene program activation of pB09 by different cell subtypes
pB09 gene program activation among cells of different subtypes (B cells).

pB09 top program genes

Top genes of pB09 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pB09 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pB09
pB09 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:306 Ribosome, cytoplasmic 3.03886143842504e-08 80 23 9 0.391304347826087 0.1125
CORUM CORUM:308 60S ribosomal subunit, cytoplasmic 7.31308686821656e-05 47 32 6 0.1875 0.127659574468085
CORUM CORUM:3055 Nop56p-associated pre-rRNA complex 0.000493765212933743 104 32 7 0.21875 0.0673076923076923
CORUM CORUM:338 40S ribosomal subunit, cytoplasmic 0.000526858037989359 31 23 4 0.173913043478261 0.129032258064516
CORUM CORUM:305 40S ribosomal subunit, cytoplasmic 0.000543543884583554 33 23 4 0.173913043478261 0.121212121212121
CORUM CORUM:5380 TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) 0.00959214463837379 25 32 3 0.09375 0.12
GO:BP GO:0006613 cotranslational protein targeting to membrane 2.07917061075246e-14 102 32 11 0.34375 0.107843137254902
GO:BP GO:0006612 protein targeting to membrane 3.61809397319266e-13 204 32 12 0.375 0.0588235294117647
GO:BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane 3.61809397319266e-13 96 32 10 0.3125 0.104166666666667
GO:BP GO:0045047 protein targeting to ER 1.46573440394241e-12 113 32 10 0.3125 0.0884955752212389
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 1.67707063399041e-12 117 32 10 0.3125 0.0854700854700855
GO:BP GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 2.33493819853441e-12 123 32 10 0.3125 0.0813008130081301
GO:BP GO:0070972 protein localization to endoplasmic reticulum 1.00693853460757e-11 146 32 10 0.3125 0.0684931506849315
GO:BP GO:0000956 nuclear-transcribed mRNA catabolic process 1.00693853460757e-11 214 23 10 0.434782608695652 0.0467289719626168
GO:BP GO:0006605 protein targeting 1.4786081030477e-11 441 24 12 0.5 0.0272108843537415
GO:BP GO:0090150 establishment of protein localization to membrane 4.2297308202221e-11 351 24 11 0.458333333333333 0.0313390313390313
GO:BP GO:0019083 viral transcription 6.42683890943052e-11 181 32 10 0.3125 0.0552486187845304
GO:BP GO:0006412 translation 1.21210483628729e-10 764 57 19 0.333333333333333 0.024869109947644
GO:BP GO:0019080 viral gene expression 1.40797040975291e-10 199 32 10 0.3125 0.050251256281407
GO:BP GO:0006413 translational initiation 1.44504192597478e-10 201 32 10 0.3125 0.0497512437810945
GO:BP GO:0043043 peptide biosynthetic process 1.63563469466792e-10 790 23 13 0.565217391304348 0.0164556962025316
GO:BP GO:0043604 amide biosynthetic process 1.23738967456848e-09 932 23 13 0.565217391304348 0.0139484978540773
GO:BP GO:0006402 mRNA catabolic process 1.47328012571209e-09 384 23 10 0.434782608695652 0.0260416666666667
GO:BP GO:0006518 peptide metabolic process 1.49453496714132e-09 955 23 13 0.565217391304348 0.0136125654450262
GO:BP GO:0006886 intracellular protein transport 2.06251331981738e-09 1186 32 16 0.5 0.0134907251264755
GO:BP GO:0072594 establishment of protein localization to organelle 2.90719308142736e-09 584 23 11 0.478260869565217 0.0188356164383562
GO:BP GO:0006401 RNA catabolic process 3.16368259770509e-09 424 23 10 0.434782608695652 0.0235849056603774
GO:BP GO:1901566 organonitrogen compound biosynthetic process 1.70193535873963e-08 1853 36 19 0.527777777777778 0.0102536427415003
GO:BP GO:0072657 protein localization to membrane 1.81127845922155e-08 665 24 11 0.458333333333333 0.0165413533834586
GO:BP GO:0043603 cellular amide metabolic process 2.947918039602e-08 1241 23 13 0.565217391304348 0.0104754230459307
GO:BP GO:1901361 organic cyclic compound catabolic process 3.36325017643125e-08 651 32 12 0.375 0.0184331797235023
GO:BP GO:0034655 nucleobase-containing compound catabolic process 4.36453541094681e-08 567 23 10 0.434782608695652 0.017636684303351
GO:BP GO:0046700 heterocycle catabolic process 7.50794358537923e-08 602 23 10 0.434782608695652 0.0166112956810631
GO:BP GO:0044270 cellular nitrogen compound catabolic process 7.96844195313716e-08 608 23 10 0.434782608695652 0.0164473684210526
GO:BP GO:0019439 aromatic compound catabolic process 9.73616876432479e-08 623 23 10 0.434782608695652 0.0160513643659711
GO:BP GO:0016071 mRNA metabolic process 1.40602960926675e-07 874 23 11 0.478260869565217 0.0125858123569794
GO:BP GO:0034613 cellular protein localization 2.3384033256512e-07 2014 28 16 0.571428571428571 0.00794438927507448
GO:BP GO:0070727 cellular macromolecule localization 2.43593921053302e-07 2024 28 16 0.571428571428571 0.00790513833992095
GO:BP GO:0046907 intracellular transport 2.66868642841001e-07 1767 24 14 0.583333333333333 0.00792303338992643
GO:BP GO:0033365 protein localization to organelle 6.05287391273755e-07 1017 23 11 0.478260869565217 0.0108161258603736
GO:BP GO:0015031 protein transport 7.87214978601184e-07 1929 24 14 0.583333333333333 0.00725764644893727
GO:BP GO:0015833 peptide transport 1.01126219182965e-06 1971 24 14 0.583333333333333 0.00710299340436327
GO:BP GO:0051649 establishment of localization in cell 1.07193580109508e-06 2813 24 16 0.666666666666667 0.00568787771062922
GO:BP GO:0042886 amide transport 1.21022318005727e-06 2007 24 14 0.583333333333333 0.00697558545092177
GO:BP GO:0045184 establishment of protein localization 1.40973803205617e-06 2035 24 14 0.583333333333333 0.00687960687960688
GO:BP GO:0002181 cytoplasmic translation 3.35109310420455e-06 103 20 5 0.25 0.0485436893203883
GO:BP GO:0071705 nitrogen compound transport 7.24568264323205e-06 2322 24 14 0.583333333333333 0.00602928509905254
GO:BP GO:0051641 cellular localization 1.17716138823807e-05 3541 28 18 0.642857142857143 0.00508330979949167
GO:BP GO:0008104 protein localization 1.64562451700664e-05 2770 28 16 0.571428571428571 0.00577617328519856
GO:BP GO:0010629 negative regulation of gene expression 1.90785015176622e-05 1460 23 11 0.478260869565217 0.00753424657534247
GO:BP GO:0044265 cellular macromolecule catabolic process 2.21035739812005e-05 1231 32 12 0.375 0.00974817221770918
GO:BP GO:0042254 ribosome biogenesis 3.27450951257232e-05 307 32 7 0.21875 0.0228013029315961
GO:BP GO:0006811 ion transport 3.78894066494378e-05 3661 24 16 0.666666666666667 0.0043703906036602
GO:BP GO:0016032 viral process 4.03818529634388e-05 942 23 9 0.391304347826087 0.00955414012738853
GO:BP GO:0006417 regulation of translation 4.04330895078751e-05 462 23 7 0.304347826086957 0.0151515151515152
GO:BP GO:0042255 ribosome assembly 4.08991305501603e-05 64 23 4 0.173913043478261 0.0625
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 4.08991305501603e-05 3241 32 18 0.5625 0.00555384140697316
GO:BP GO:0071702 organic substance transport 5.12795408113562e-05 2766 24 14 0.583333333333333 0.00506146059291396
GO:BP GO:0000028 ribosomal small subunit assembly 5.5398485607248e-05 19 23 3 0.130434782608696 0.157894736842105
GO:BP GO:0044403 biological process involved in symbiotic interaction 5.95484668680637e-05 1001 23 9 0.391304347826087 0.00899100899100899
GO:BP GO:0033036 macromolecule localization 6.24212915352908e-05 3218 33 18 0.545454545454545 0.00559353635798633
GO:BP GO:0042274 ribosomal small subunit biogenesis 6.56804548867448e-05 74 23 4 0.173913043478261 0.0540540540540541
GO:BP GO:0006820 anion transport 8.00336203115152e-05 2889 24 14 0.583333333333333 0.00484596746278989
GO:BP GO:0034248 regulation of cellular amide metabolic process 9.06242589834568e-05 535 23 7 0.304347826086957 0.0130841121495327
GO:BP GO:0009892 negative regulation of metabolic process 0.000103017551240984 3479 32 18 0.5625 0.00517390054613395
GO:BP GO:0009057 macromolecule catabolic process 0.000106982657202911 1468 32 12 0.375 0.00817438692098093
GO:BP GO:0044248 cellular catabolic process 0.000207110192935207 2347 23 12 0.521739130434783 0.00511291009799744
GO:BP GO:0042273 ribosomal large subunit biogenesis 0.000234306353056474 74 32 4 0.125 0.0540540540540541
GO:BP GO:0022613 ribonucleoprotein complex biogenesis 0.000281557177747177 446 32 7 0.21875 0.015695067264574
GO:BP GO:0009056 catabolic process 0.000423182278211915 2744 28 14 0.5 0.00510204081632653
GO:BP GO:0006810 transport 0.000648661312584561 5224 24 17 0.708333333333333 0.0032542113323124
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 0.000919596603973449 5017 23 16 0.695652173913043 0.00318915686665338
GO:BP GO:0051234 establishment of localization 0.000940497307406713 5372 24 17 0.708333333333333 0.00316455696202532
GO:BP GO:0006364 rRNA processing 0.00107074341481188 224 32 5 0.15625 0.0223214285714286
GO:BP GO:0034645 cellular macromolecule biosynthetic process 0.00112160216363273 5051 32 20 0.625 0.00395961195802811
GO:BP GO:0006414 translational elongation 0.00114967821421946 141 51 5 0.0980392156862745 0.0354609929078014
GO:BP GO:0016072 rRNA metabolic process 0.0012624200798278 234 32 5 0.15625 0.0213675213675214
GO:BP GO:0009059 macromolecule biosynthetic process 0.00130617211237244 5114 32 20 0.625 0.00391083300743058
GO:BP GO:0034470 ncRNA processing 0.00140300762904991 397 32 6 0.1875 0.0151133501259446
GO:BP GO:1901575 organic substance catabolic process 0.00141200819233491 2267 32 13 0.40625 0.00573445081605646
GO:BP GO:0044249 cellular biosynthetic process 0.00141200819233491 6154 32 22 0.6875 0.00357491062723432
GO:BP GO:1901576 organic substance biosynthetic process 0.00180952969253653 6248 32 22 0.6875 0.00352112676056338
GO:BP GO:0010608 posttranscriptional regulation of gene expression 0.00190008783845045 896 23 7 0.304347826086957 0.0078125
GO:BP GO:0048519 negative regulation of biological process 0.00190008783845045 5757 32 21 0.65625 0.00364773319437207
GO:BP GO:0010467 gene expression 0.00213891667605219 6179 21 16 0.761904761904762 0.00258941576306846
GO:BP GO:0022618 ribonucleoprotein complex assembly 0.00218095261012047 197 23 4 0.173913043478261 0.0203045685279188
GO:BP GO:0009058 biosynthetic process 0.00218095261012047 6340 32 22 0.6875 0.00347003154574133
GO:BP GO:0071826 ribonucleoprotein complex subunit organization 0.00244835735194995 204 23 4 0.173913043478261 0.0196078431372549
GO:BP GO:1901564 organonitrogen compound metabolic process 0.00251424767791398 6792 44 29 0.659090909090909 0.00426972909305065
GO:BP GO:0045727 positive regulation of translation 0.0033960987439298 140 36 4 0.111111111111111 0.0285714285714286
GO:BP GO:0042542 response to hydrogen peroxide 0.00382777311379122 150 14 3 0.214285714285714 0.02
GO:BP GO:0019538 protein metabolic process 0.00389334391456426 5808 44 26 0.590909090909091 0.00447658402203857
GO:BP GO:0034660 ncRNA metabolic process 0.00389334391456426 493 32 6 0.1875 0.0121703853955375
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.00418282808147552 2255 23 10 0.434782608695652 0.00443458980044346
GO:BP GO:0006950 response to stress 0.00420589141291644 4170 8 7 0.875 0.00167865707434053
GO:BP GO:0034641 cellular nitrogen compound metabolic process 0.0049094609900221 6563 23 17 0.739130434782609 0.00259027883589822
GO:BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 0.0049094609900221 167 14 3 0.214285714285714 0.0179640718562874
GO:BP GO:0051179 localization 0.0049094609900221 6901 24 18 0.75 0.00260831763512534
GO:BP GO:0044267 cellular protein metabolic process 0.00509511750917203 5229 25 16 0.64 0.00305985848154523
GO:BP GO:0010468 regulation of gene expression 0.00538375132627298 5196 23 15 0.652173913043478 0.00288683602771363
GO:BP GO:0034250 positive regulation of cellular amide metabolic process 0.00638100032512703 171 36 4 0.111111111111111 0.0233918128654971
GO:BP GO:0016070 RNA metabolic process 0.00755958161087996 4710 23 14 0.608695652173913 0.0029723991507431
GO:BP GO:0007519 skeletal muscle tissue development 0.0098472350679639 160 19 3 0.157894736842105 0.01875
GO:BP GO:0044237 cellular metabolic process 0.0107647556812278 10871 36 31 0.861111111111111 0.00285162358568669
GO:BP GO:0000302 response to reactive oxygen species 0.0115046830068143 237 14 3 0.214285714285714 0.0126582278481013
GO:BP GO:0060538 skeletal muscle organ development 0.0115046830068143 170 19 3 0.157894736842105 0.0176470588235294
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.0147212801879674 5746 23 15 0.652173913043478 0.00261051166028542
GO:BP GO:0097193 intrinsic apoptotic signaling pathway 0.0178200573743567 294 14 3 0.214285714285714 0.0102040816326531
GO:BP GO:0046483 heterocycle metabolic process 0.0178200573743567 5904 23 15 0.652173913043478 0.00254065040650406
GO:BP GO:0090304 nucleic acid metabolic process 0.0178928867003046 5226 23 14 0.608695652173913 0.00267891312667432
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.0192873870063428 5956 23 15 0.652173913043478 0.00251846877098724
GO:BP GO:0006396 RNA processing 0.0218746888005876 964 34 7 0.205882352941176 0.00726141078838174
GO:BP GO:0065007 biological regulation 0.0228491579322066 12809 18 18 1 0.00140526192520884
GO:BP GO:0051246 regulation of protein metabolic process 0.0237338047345447 2704 25 10 0.4 0.00369822485207101
GO:BP GO:1901360 organic cyclic compound metabolic process 0.0268985840426515 6201 23 15 0.652173913043478 0.00241896468311563
GO:BP GO:0006915 apoptotic process 0.0270937320117658 1990 14 6 0.428571428571429 0.00301507537688442
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.0270937320117658 6603 32 20 0.625 0.00302892624564592
GO:BP GO:0019222 regulation of metabolic process 0.027111958709139 7148 32 21 0.65625 0.00293788472299944
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.0271307221134882 363 14 3 0.214285714285714 0.00826446280991736
GO:BP GO:0009611 response to wounding 0.0271307221134882 674 8 3 0.375 0.00445103857566766
GO:BP GO:0034976 response to endoplasmic reticulum stress 0.0296056529355439 298 36 4 0.111111111111111 0.0134228187919463
GO:BP GO:0042981 regulation of apoptotic process 0.0296519674130773 1549 8 4 0.5 0.0025823111684958
GO:BP GO:0044260 cellular macromolecule metabolic process 0.0311096380475383 8390 32 23 0.71875 0.00274135876042908
GO:BP GO:0043067 regulation of programmed cell death 0.0311096380475383 1582 8 4 0.5 0.00252844500632111
GO:BP GO:0012501 programmed cell death 0.0339050054225438 2143 14 6 0.428571428571429 0.00279981334577695
GO:BP GO:0006457 protein folding 0.0357987541578758 225 26 3 0.115384615384615 0.0133333333333333
GO:BP GO:0010941 regulation of cell death 0.0362142509991548 1720 8 4 0.5 0.00232558139534884
GO:BP GO:0007517 muscle organ development 0.0362142509991548 333 36 4 0.111111111111111 0.012012012012012
GO:BP GO:0034622 cellular protein-containing complex assembly 0.0362142509991548 1107 26 6 0.230769230769231 0.00542005420054201
GO:BP GO:0044238 primary metabolic process 0.0375241868654956 10584 36 29 0.805555555555556 0.00273998488284203
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0375241868654956 1151 42 8 0.19047619047619 0.00695047784535187
GO:BP GO:0070925 organelle assembly 0.0389894525024272 895 23 5 0.217391304347826 0.00558659217877095
GO:BP GO:0008152 metabolic process 0.0392180894320726 11827 36 31 0.861111111111111 0.00262112116343959
GO:BP GO:0008219 cell death 0.0409519036064706 2292 14 6 0.428571428571429 0.00261780104712042
GO:BP GO:0006979 response to oxidative stress 0.0409519036064706 466 14 3 0.214285714285714 0.00643776824034335
GO:BP GO:2000113 negative regulation of cellular macromolecule biosynthetic process 0.040989721660146 1628 31 8 0.258064516129032 0.00491400491400491
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0410229262001425 2541 25 9 0.36 0.00354191263282172
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 0.0417583776320131 1639 31 8 0.258064516129032 0.0048810250152532
GO:BP GO:0090559 regulation of membrane permeability 0.0417583776320131 95 67 3 0.0447761194029851 0.0315789473684211
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 0.0491844589599733 1707 31 8 0.258064516129032 0.00468658465143527
GO:CC GO:0022626 cytosolic ribosome 4.92260851027852e-13 109 32 10 0.3125 0.0917431192660551
GO:CC GO:0005840 ribosome 2.58198180410195e-12 245 36 12 0.333333333333333 0.0489795918367347
GO:CC GO:0044391 ribosomal subunit 4.6894265938369e-11 190 32 10 0.3125 0.0526315789473684
GO:CC GO:0005844 polysome 7.38687214563853e-09 72 20 6 0.3 0.0833333333333333
GO:CC GO:0042788 polysomal ribosome 1.36050279223263e-08 34 20 5 0.25 0.147058823529412
GO:CC GO:0022625 cytosolic large ribosomal subunit 2.62593086283961e-08 57 32 6 0.1875 0.105263157894737
GO:CC GO:0005925 focal adhesion 3.43096188956274e-08 420 23 9 0.391304347826087 0.0214285714285714
GO:CC GO:0030055 cell-substrate junction 3.47210545321396e-08 427 23 9 0.391304347826087 0.0210772833723653
GO:CC GO:1990904 ribonucleoprotein complex 4.54891706700401e-08 688 34 12 0.352941176470588 0.0174418604651163
GO:CC GO:0015934 large ribosomal subunit 1.33144147378713e-06 118 32 6 0.1875 0.0508474576271186
GO:CC GO:0005737 cytoplasm 1.57718726349314e-06 11911 36 36 1 0.00302241625388297
GO:CC GO:0070161 anchoring junction 6.87986653783025e-06 836 23 9 0.391304347826087 0.0107655502392345
GO:CC GO:0043229 intracellular organelle 6.87986653783025e-06 12491 36 36 1 0.00288207509406773
GO:CC GO:0022627 cytosolic small ribosomal subunit 6.87986653783025e-06 47 23 4 0.173913043478261 0.0851063829787234
GO:CC GO:0015935 small ribosomal subunit 4.13009057925148e-05 75 23 4 0.173913043478261 0.0533333333333333
GO:CC GO:0005829 cytosol 0.000127906323777534 5303 23 17 0.739130434782609 0.00320573260418631
GO:CC GO:0030054 cell junction 0.000141985373302282 2105 26 12 0.461538461538462 0.00570071258907363
GO:CC GO:0043226 organelle 0.000333313739449868 14008 36 36 1 0.00256996002284409
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.000346554257674583 11296 36 33 0.916666666666667 0.002921388101983
GO:CC GO:0005622 intracellular anatomical structure 0.00199906658806354 14790 36 36 1 0.00243407707910751
GO:CC GO:0070062 extracellular exosome 0.00199906658806354 2176 32 12 0.375 0.00551470588235294
GO:CC GO:0043227 membrane-bounded organelle 0.00199906658806354 12858 36 34 0.944444444444444 0.00264426815990045
GO:CC GO:0043230 extracellular organelle 0.00250699178185248 2263 32 12 0.375 0.00530269553689792
GO:CC GO:1903561 extracellular vesicle 0.00250699178185248 2261 32 12 0.375 0.00530738611233967
GO:CC GO:0014069 postsynaptic density 0.00294217336213858 334 32 5 0.15625 0.0149700598802395
GO:CC GO:0032279 asymmetric synapse 0.00295824360954468 340 32 5 0.15625 0.0147058823529412
GO:CC GO:0005783 endoplasmic reticulum 0.00295824360954468 1982 76 19 0.25 0.00958627648839556
GO:CC GO:0045202 synapse 0.00334018940615834 1349 32 9 0.28125 0.00667160859896219
GO:CC GO:0099572 postsynaptic specialization 0.00349425235513971 358 32 5 0.15625 0.0139664804469274
GO:CC GO:0098984 neuron to neuron synapse 0.00373894312399169 366 32 5 0.15625 0.0136612021857923
GO:CC GO:0032991 protein-containing complex 0.00397350276613009 5548 23 15 0.652173913043478 0.00270367700072098
GO:CC GO:0005730 nucleolus 0.00587173818602177 955 30 7 0.233333333333333 0.00732984293193717
GO:CC GO:0043228 non-membrane-bounded organelle 0.00897151581904248 5346 23 14 0.608695652173913 0.00261878039655817
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 0.00897151581904248 5338 23 14 0.608695652173913 0.00262270513300862
GO:CC GO:0012505 endomembrane system 0.0185725658156431 4640 76 30 0.394736842105263 0.00646551724137931
GO:CC GO:0098794 postsynapse 0.0271331756558583 639 32 5 0.15625 0.00782472613458529
GO:CC GO:0005634 nucleus 0.0271331756558583 7592 23 16 0.695652173913043 0.00210748155953635
GO:CC GO:0031968 organelle outer membrane 0.0465415243586333 227 67 4 0.0597014925373134 0.0176211453744493
GO:CC GO:0019867 outer membrane 0.0471768754298128 229 67 4 0.0597014925373134 0.0174672489082969
GO:MF GO:0003735 structural constituent of ribosome 5.18456814827252e-11 171 32 10 0.3125 0.0584795321637427
GO:MF GO:0019843 rRNA binding 1.79526841202695e-06 63 23 5 0.217391304347826 0.0793650793650794
GO:MF GO:0003723 RNA binding 5.19193230050214e-06 1943 23 13 0.565217391304348 0.00669068450849202
GO:MF GO:0005198 structural molecule activity 5.19193230050214e-06 698 23 9 0.391304347826087 0.0128939828080229
GO:MF GO:0003746 translation elongation factor activity 4.97426864553127e-05 27 51 4 0.0784313725490196 0.148148148148148
GO:MF GO:0045182 translation regulator activity 0.00247680793974142 155 51 5 0.0980392156862745 0.032258064516129
GO:MF GO:0003676 nucleic acid binding 0.00342258254480514 4276 23 14 0.608695652173913 0.00327408793264733
GO:MF GO:0008135 translation factor activity, RNA binding 0.00461568779243343 99 51 4 0.0784313725490196 0.0404040404040404
GO:MF GO:0090079 translation regulator activity, nucleic acid binding 0.00964396187704431 123 51 4 0.0784313725490196 0.032520325203252
GO:MF GO:0003729 mRNA binding 0.0115717405724131 552 23 5 0.217391304347826 0.00905797101449275
GO:MF GO:1901363 heterocyclic compound binding 0.0292003305218056 6228 23 15 0.652173913043478 0.00240847784200385
GO:MF GO:0097159 organic cyclic compound binding 0.0304590411868884 6309 23 15 0.652173913043478 0.00237755587256301
GO:MF GO:0001540 amyloid-beta binding 0.042237501938686 83 72 3 0.0416666666666667 0.036144578313253
GO:MF GO:0030234 enzyme regulator activity 0.0450332951207705 1248 6 3 0.5 0.00240384615384615
KEGG KEGG:03010 Ribosome 1.42293415347971e-08 153 23 9 0.391304347826087 0.0588235294117647
KEGG KEGG:05171 Coronavirus disease - COVID-19 2.77735226662509e-07 231 23 9 0.391304347826087 0.038961038961039
MIRNA MIRNA:hsa-miR-615-3p hsa-miR-615-3p 0.00624693794414335 891 24 9 0.375 0.0101010101010101
MIRNA MIRNA:hsa-miR-18a-5p hsa-miR-18a-5p 0.00627954524231642 260 18 5 0.277777777777778 0.0192307692307692
MIRNA MIRNA:hsa-miR-16-5p hsa-miR-16-5p 0.0114436125072476 1556 22 10 0.454545454545455 0.006426735218509
MIRNA MIRNA:hsa-miR-27b-3p hsa-miR-27b-3p 0.0171537033813806 419 4 3 0.75 0.00715990453460621
MIRNA MIRNA:hsa-miR-27a-3p hsa-miR-27a-3p 0.0171537033813806 427 4 3 0.75 0.00702576112412178
MIRNA MIRNA:hsa-miR-186-5p hsa-miR-186-5p 0.0428137928847554 749 36 8 0.222222222222222 0.0106809078771696
MIRNA MIRNA:hsa-miR-1299 hsa-miR-1299 0.0428137928847554 89 24 3 0.125 0.0337078651685393
MIRNA MIRNA:hsa-miR-4464 hsa-miR-4464 0.0428137928847554 87 23 3 0.130434782608696 0.0344827586206897
MIRNA MIRNA:hsa-miR-4748 hsa-miR-4748 0.0428137928847554 88 23 3 0.130434782608696 0.0340909090909091
REAC REAC:R-HSA-156842 Eukaryotic Translation Elongation 5.18208165830191e-15 94 23 11 0.478260869565217 0.117021276595745
REAC REAC:R-HSA-156902 Peptide chain elongation 1.40609187790746e-13 90 32 11 0.34375 0.122222222222222
REAC REAC:R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 1.25556391473156e-12 113 32 11 0.34375 0.0973451327433628
REAC REAC:R-HSA-192823 Viral mRNA Translation 4.59352955163347e-12 90 32 10 0.3125 0.111111111111111
REAC REAC:R-HSA-2408557 Selenocysteine synthesis 4.80306146847796e-12 94 32 10 0.3125 0.106382978723404
REAC REAC:R-HSA-72764 Eukaryotic Translation Termination 4.80306146847796e-12 94 32 10 0.3125 0.106382978723404
REAC REAC:R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 5.11667721921436e-12 96 32 10 0.3125 0.104166666666667
REAC REAC:R-HSA-72689 Formation of a pool of free 40S subunits 7.42934689863183e-12 102 32 10 0.3125 0.0980392156862745
REAC REAC:R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 7.42934689863183e-12 102 32 10 0.3125 0.0980392156862745
REAC REAC:R-HSA-72766 Translation 8.83498180673993e-12 292 24 12 0.5 0.0410958904109589
REAC REAC:R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 1.58439204923548e-11 112 32 10 0.3125 0.0892857142857143
REAC REAC:R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 1.59031765813553e-11 113 32 10 0.3125 0.0884955752212389
REAC REAC:R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1.78063383388577e-11 116 32 10 0.3125 0.0862068965517241
REAC REAC:R-HSA-927802 Nonsense-Mediated Decay (NMD) 1.78063383388577e-11 116 32 10 0.3125 0.0862068965517241
REAC REAC:R-HSA-2408522 Selenoamino acid metabolism 1.81376833008337e-11 117 32 10 0.3125 0.0854700854700855
REAC REAC:R-HSA-72737 Cap-dependent Translation Initiation 2.07059934245398e-11 120 32 10 0.3125 0.0833333333333333
REAC REAC:R-HSA-72613 Eukaryotic Translation Initiation 2.07059934245398e-11 120 32 10 0.3125 0.0833333333333333
REAC REAC:R-HSA-168273 Influenza Viral RNA Transcription and Replication 5.54527122476402e-11 133 32 10 0.3125 0.075187969924812
REAC REAC:R-HSA-168255 Influenza Infection 2.01261847193636e-10 152 32 10 0.3125 0.0657894736842105
REAC REAC:R-HSA-9711097 Cellular response to starvation 2.64106407052551e-10 157 23 9 0.391304347826087 0.0573248407643312
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 5.43930502413132e-10 171 23 9 0.391304347826087 0.0526315789473684
REAC REAC:R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 9.55683432716078e-10 183 23 9 0.391304347826087 0.0491803278688525
REAC REAC:R-HSA-8868773 rRNA processing in the nucleus and cytosol 1.47320260230617e-09 193 23 9 0.391304347826087 0.0466321243523316
REAC REAC:R-HSA-72312 rRNA processing 2.21852871213341e-09 203 23 9 0.391304347826087 0.0443349753694581
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 3.8612735098933e-09 217 23 9 0.391304347826087 0.0414746543778802
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 3.83904681638699e-07 368 23 9 0.391304347826087 0.0244565217391304
REAC REAC:R-HSA-5663205 Infectious disease 3.13957008224737e-06 815 23 11 0.478260869565217 0.0134969325153374
REAC REAC:R-HSA-2262752 Cellular responses to stress 1.02923313144091e-05 546 23 9 0.391304347826087 0.0164835164835165
REAC REAC:R-HSA-422475 Axon guidance 1.04046155373431e-05 549 23 9 0.391304347826087 0.0163934426229508
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 1.18755659378418e-05 560 23 9 0.391304347826087 0.0160714285714286
REAC REAC:R-HSA-9675108 Nervous system development 1.41263703626023e-05 574 23 9 0.391304347826087 0.0156794425087108
REAC REAC:R-HSA-8953854 Metabolism of RNA 3.30943871034478e-05 658 34 11 0.323529411764706 0.0167173252279635
REAC REAC:R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 3.55687038166798e-05 52 23 4 0.173913043478261 0.0769230769230769
REAC REAC:R-HSA-72649 Translation initiation complex formation 5.58117235721719e-05 59 23 4 0.173913043478261 0.0677966101694915
REAC REAC:R-HSA-72702 Ribosomal scanning and start codon recognition 5.58117235721719e-05 59 23 4 0.173913043478261 0.0677966101694915
REAC REAC:R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 5.80532797580574e-05 60 23 4 0.173913043478261 0.0666666666666667
REAC REAC:R-HSA-392499 Metabolism of proteins 0.00071588087040332 1961 24 13 0.541666666666667 0.00662927078021418
REAC REAC:R-HSA-1643685 Disease 0.000851647958287729 1509 59 20 0.338983050847458 0.0132538104705103
REAC REAC:R-HSA-5339562 Uptake and actions of bacterial toxins 0.00139802632517329 25 49 3 0.0612244897959184 0.12
REAC REAC:R-HSA-1266738 Developmental Biology 0.00161900681198935 1069 23 9 0.391304347826087 0.00841908325537886
REAC REAC:R-HSA-1430728 Metabolism 0.00909368615305633 2070 35 15 0.428571428571429 0.0072463768115942
TF TF:M06531 Factor: ZNF555; motif: NCRWGTTTGKCC 0.0157866880599217 244 12 4 0.333333333333333 0.0163934426229508
TF TF:M04696_1 Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN; match class: 1 0.0157866880599217 1973 18 9 0.5 0.00456158134820071
TF TF:M07374 Factor: Bach1; motif: GCTGAGTCAYGNT 0.0157866880599217 93 72 5 0.0694444444444444 0.0537634408602151
TF TF:M02052 Factor: EHF; motif: CSCGGAARTN 0.0157866880599217 10107 72 54 0.75 0.00534283170080142
TF TF:M00940_1 Factor: E2F-1; motif: NTTTCGCGCS; match class: 1 0.0157866880599217 2643 21 11 0.523809523809524 0.00416193719258418
TF TF:M11404_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.0157866880599217 3171 31 15 0.483870967741935 0.00473036896877956
TF TF:M11535_1 Factor: E2F-4; motif: TTTTGGCGCCAWWN; match class: 1 0.0157866880599217 6532 18 15 0.833333333333333 0.00229638701775873
TF TF:M03988_1 Factor: FLI1; motif: ACCGGAARTN; match class: 1 0.0157866880599217 2950 31 15 0.483870967741935 0.00508474576271186
TF TF:M00426_1 Factor: E2F; motif: TTTSGCGS; match class: 1 0.0157866880599217 5830 21 16 0.761904761904762 0.00274442538593482
TF TF:M08759 Factor: c-Ets-2; motif: NCCGGAAGTG 0.0157866880599217 8319 60 42 0.7 0.00504868373602596
TF TF:M08875_1 Factor: E2F; motif: NNTTTCGCGCN; match class: 1 0.0157866880599217 1719 21 9 0.428571428571429 0.00523560209424084
TF TF:M11541 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN 0.021791438826279 5751 59 32 0.542372881355932 0.00556424969570509
TF TF:M09893 Factor: E2F-3; motif: NNGGCGGGAAA 0.0222567191397031 6065 18 14 0.777777777777778 0.0023083264633141
TF TF:M00777 Factor: STAT; motif: NNNNNTTCTKGGA 0.0222567191397031 5166 14 11 0.785714285714286 0.00212930700735579
TF TF:M11435 Factor: Elk-1; motif: NNCCGGAAGTN 0.0222567191397031 11728 60 50 0.833333333333333 0.00426330150068213
TF TF:M04710_1 Factor: CHD2; motif: TCTCGCGAG; match class: 1 0.0222567191397031 11477 32 29 0.90625 0.00252679271586652
TF TF:M06114 Factor: ZNF432; motif: NCRTCATMGCGM 0.0251734650346449 198 9 3 0.333333333333333 0.0151515151515152
TF TF:M11768 Factor: Nur77; motif: NAAAGGTCAN 0.0251734650346449 35 47 3 0.0638297872340425 0.0857142857142857
TF TF:M08526_1 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 0.0270989043286459 14997 60 57 0.95 0.00380076015203041
TF TF:M04710 Factor: CHD2; motif: TCTCGCGAG 0.0318723511697222 14109 27 27 1 0.00191367212417606
TF TF:M02062_1 Factor: Erg; motif: ACCGGAAGTN; match class: 1 0.0318723511697222 2718 31 13 0.419354838709677 0.00478292862398823
TF TF:M08451 Factor: Elk-1:HOXA1; motif: ACCGGAAGTAATTA 0.0356160700026401 8421 60 40 0.666666666666667 0.00475002968768555
TF TF:M11541_1 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN; match class: 1 0.0356160700026401 5493 59 30 0.508474576271186 0.00546149645002731
TF TF:M02070_1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 0.0356160700026401 4841 20 13 0.65 0.00268539557942574
TF TF:M00736 Factor: E2F-1:DP-1; motif: TTTCSCGC 0.0356160700026401 10390 29 25 0.862068965517241 0.00240615976900866
TF TF:M07380 Factor: E2F-4; motif: NTTTCSCGCC 0.0356943432427247 13022 33 31 0.939393939393939 0.00238058669943173
TF TF:M10799_1 Factor: HOXA10; motif: NRTCGTAAANN; match class: 1 0.0356943432427247 1078 11 5 0.454545454545455 0.00463821892393321
TF TF:M11987 Factor: NFATc3; motif: NAYGGAAANW 0.0356943432427247 2409 75 21 0.28 0.0087173100871731
TF TF:M11428 Factor: PEA3; motif: NACCGGAAGTN 0.0356943432427247 7186 60 36 0.6 0.00500974116337323
TF TF:M03971 Factor: ELK1; motif: NACTTCCGSCGGAAGYN 0.0368540693023368 11293 66 52 0.787878787878788 0.00460462233241831
TF TF:M11984_1 Factor: NFATc2; motif: NTTTCCRTNNAYGGAAAN; match class: 1 0.0368540693023368 10881 27 24 0.888888888888889 0.00220567962503446
TF TF:M11882_1 Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 0.0368540693023368 11423 33 29 0.878787878787879 0.00253873763459687
TF TF:M11984 Factor: NFATc2; motif: NTTTCCRTNNAYGGAAAN 0.0378977932155169 10942 27 24 0.888888888888889 0.00219338329373058
TF TF:M08461 Factor: Erm:EVX1; motif: NNCGGAAATKR 0.0383858032089487 3396 24 12 0.5 0.00353356890459364
TF TF:M03874 Factor: Hoxa9; motif: ATYAATDACATC 0.0383858032089487 2481 27 11 0.407407407407407 0.00443369609028618
TF TF:M08874_1 Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 0.0420911181652572 2135 22 9 0.409090909090909 0.00421545667447307
TF TF:M11392_1 Factor: Erg; motif: NACCGGAARYN; match class: 1 0.0421600954335358 3233 36 15 0.416666666666667 0.00463965357253325
TF TF:M03975_1 Factor: ERG; motif: ACCGGAARTN; match class: 1 0.0421600954335358 4024 36 17 0.472222222222222 0.00422465208747515
TF TF:M11221 Factor: CREB1; motif: RTGACGYGTCAN 0.0436052293507391 9677 42 32 0.761904761904762 0.00330680996176501
TF TF:M11396 Factor: Erg; motif: NACCGGAARTN 0.0436052293507391 10765 66 50 0.757575757575758 0.00464468183929401
TF TF:M01660 Factor: GABP-alpha; motif: CTTCCK 0.0436289144137696 11116 60 47 0.783333333333333 0.00422813961856783
TF TF:M09882 Factor: C/EBPdelta; motif: NTTGCNCMAYN 0.0467547037947564 2027 15 7 0.466666666666667 0.00345337937839171
TF TF:M09900 Factor: Elf-1; motif: NNANCCGGAAGTGS 0.0467547037947564 5219 53 26 0.490566037735849 0.00498179727917226
TF TF:M02065 Factor: ER81; motif: RCCGGAARYN 0.0467547037947564 12550 66 55 0.833333333333333 0.00438247011952191
TF TF:M11425 Factor: PEA3; motif: NACCGGAAGTN 0.0467547037947564 7428 60 36 0.6 0.00484652665589661
WP WP:WP477 Cytoplasmic Ribosomal Proteins 1.18143722042279e-10 90 32 10 0.3125 0.111111111111111

pB09 transcription factor target enrichment of top program genes

TF enrichment of pB09
TFs corrosponding to activation of pB09. (Left) pearson correlation of TF expression and gene expression program activatity in B cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.