pB10 program activity among B cells

Activation of pB10
pB10 gene program activation in B cells.
Gene program activation of pB10 by different cell subtypes
pB10 gene program activation among cells of different subtypes (B cells).

pB10 top program genes

Top genes of pB10 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pB10 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pB10
pB10 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002250 adaptive immune response 0.000161815199065432 689 18 8 0.444444444444444 0.011611030478955
GO:BP GO:0006955 immune response 0.000161815199065432 2311 55 22 0.4 0.00951968844655993
GO:BP GO:0045321 leukocyte activation 0.000161815199065432 1332 55 17 0.309090909090909 0.0127627627627628
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.000161815199065432 365 34 8 0.235294117647059 0.0219178082191781
GO:BP GO:0050776 regulation of immune response 0.000161815199065432 996 11 7 0.636363636363636 0.0070281124497992
GO:BP GO:0002376 immune system process 0.000205929298407062 3278 55 26 0.472727272727273 0.00793166564978645
GO:BP GO:0002694 regulation of leukocyte activation 0.000205929298407062 610 25 8 0.32 0.0131147540983607
GO:BP GO:0001775 cell activation 0.000205929298407062 1495 38 14 0.368421052631579 0.00936454849498328
GO:BP GO:0002696 positive regulation of leukocyte activation 0.000205929298407062 412 34 8 0.235294117647059 0.0194174757281553
GO:BP GO:0050867 positive regulation of cell activation 0.000205929298407062 424 34 8 0.235294117647059 0.0188679245283019
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 0.000263739767621915 241 43 7 0.162790697674419 0.029045643153527
GO:BP GO:0098609 cell-cell adhesion 0.000265208223060646 894 54 13 0.240740740740741 0.0145413870246085
GO:BP GO:0050865 regulation of cell activation 0.000270228197978143 655 25 8 0.32 0.0122137404580153
GO:BP GO:0050778 positive regulation of immune response 0.000279451779428663 753 11 6 0.545454545454545 0.00796812749003984
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.000293453244471019 375 43 8 0.186046511627907 0.0213333333333333
GO:BP GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 0.000293453244471019 103 17 4 0.235294117647059 0.0388349514563107
GO:BP GO:0002455 humoral immune response mediated by circulating immunoglobulin 0.000293453244471019 156 4 3 0.75 0.0192307692307692
GO:BP GO:0050870 positive regulation of T cell activation 0.000328775617311613 219 34 6 0.176470588235294 0.0273972602739726
GO:BP GO:0051249 regulation of lymphocyte activation 0.000420682736726824 518 34 8 0.235294117647059 0.0154440154440154
GO:BP GO:0022409 positive regulation of cell-cell adhesion 0.000422537254794436 284 43 7 0.162790697674419 0.0246478873239437
GO:BP GO:0016064 immunoglobulin mediated immune response 0.000422537254794436 223 10 4 0.4 0.0179372197309417
GO:BP GO:0019724 B cell mediated immunity 0.000425289526542191 226 10 4 0.4 0.0176991150442478
GO:BP GO:0002252 immune effector process 0.000464891882347046 1309 55 15 0.272727272727273 0.0114591291061879
GO:BP GO:0022407 regulation of cell-cell adhesion 0.000708267355237082 445 43 8 0.186046511627907 0.0179775280898876
GO:BP GO:0045087 innate immune response 0.000802561547263575 998 11 6 0.545454545454545 0.00601202404809619
GO:BP GO:0002682 regulation of immune system process 0.000820859281454955 1617 11 7 0.636363636363636 0.00432900432900433
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 0.000992625915921589 338 43 7 0.162790697674419 0.0207100591715976
GO:BP GO:0002684 positive regulation of immune system process 0.00104179459579289 1065 11 6 0.545454545454545 0.00563380281690141
GO:BP GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 0.0015145732235348 96 11 3 0.272727272727273 0.03125
GO:BP GO:0046649 lymphocyte activation 0.0015145732235348 771 38 9 0.236842105263158 0.0116731517509728
GO:BP GO:0006959 humoral immune response 0.0015145732235348 384 9 4 0.444444444444444 0.0104166666666667
GO:BP GO:0098542 defense response to other organism 0.0015222094338771 1218 15 7 0.466666666666667 0.00574712643678161
GO:BP GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 0.00158332910508148 100 11 3 0.272727272727273 0.03
GO:BP GO:0002449 lymphocyte mediated immunity 0.00161633443706044 354 10 4 0.4 0.0112994350282486
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.00163891615186942 363 10 4 0.4 0.0110192837465565
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.00163891615186942 323 11 4 0.363636363636364 0.0123839009287926
GO:BP GO:0002443 leukocyte mediated immunity 0.00167091618698521 877 35 9 0.257142857142857 0.0102622576966933
GO:BP GO:0050863 regulation of T cell activation 0.00176389185591389 337 34 6 0.176470588235294 0.0178041543026706
GO:BP GO:0002366 leukocyte activation involved in immune response 0.00248848617996159 717 66 11 0.166666666666667 0.0153417015341702
GO:BP GO:0002263 cell activation involved in immune response 0.00251895536915188 721 66 11 0.166666666666667 0.0152565880721221
GO:BP GO:0019882 antigen processing and presentation 0.00251895536915188 234 17 4 0.235294117647059 0.0170940170940171
GO:BP GO:0050871 positive regulation of B cell activation 0.00272420376172948 151 10 3 0.3 0.0198675496688742
GO:BP GO:0045785 positive regulation of cell adhesion 0.00281639917733895 437 43 7 0.162790697674419 0.0160183066361556
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 0.00291542378123717 141 11 3 0.272727272727273 0.0212765957446809
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 0.00291897753016265 142 11 3 0.272727272727273 0.0211267605633803
GO:BP GO:0007155 cell adhesion 0.00335444935497458 1492 54 14 0.259259259259259 0.00938337801608579
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.00345143581398253 2255 11 7 0.636363636363636 0.00310421286031042
GO:BP GO:0022610 biological adhesion 0.00345143581398253 1499 54 14 0.259259259259259 0.00933955970647098
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.00345143581398253 155 11 3 0.272727272727273 0.0193548387096774
GO:BP GO:0006952 defense response 0.00345143581398253 1818 21 9 0.428571428571429 0.00495049504950495
GO:BP GO:0001819 positive regulation of cytokine production 0.00371482676795498 452 20 5 0.25 0.0110619469026549
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.00376969348530792 512 18 5 0.277777777777778 0.009765625
GO:BP GO:0002764 immune response-regulating signaling pathway 0.00376969348530792 515 18 5 0.277777777777778 0.00970873786407767
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.00389319720704697 1455 26 9 0.346153846153846 0.00618556701030928
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 0.00411252587153774 174 11 3 0.272727272727273 0.0172413793103448
GO:BP GO:0051707 response to other organism 0.00411252587153774 1592 15 7 0.466666666666667 0.00439698492462312
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.00411252587153774 477 11 4 0.363636363636364 0.00838574423480084
GO:BP GO:0043207 response to external biotic stimulus 0.00411252587153774 1594 15 7 0.466666666666667 0.00439146800501882
GO:BP GO:0002757 immune response-activating signal transduction 0.00411252587153774 477 11 4 0.363636363636364 0.00838574423480084
GO:BP GO:0002274 myeloid leukocyte activation 0.00412921486286088 667 66 10 0.151515151515152 0.0149925037481259
GO:BP GO:0009607 response to biotic stimulus 0.0044080907012792 1626 15 7 0.466666666666667 0.0043050430504305
GO:BP GO:0042742 defense response to bacterium 0.0044080907012792 349 15 4 0.266666666666667 0.0114613180515759
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 0.0044080907012792 182 11 3 0.272727272727273 0.0164835164835165
GO:BP GO:0030155 regulation of cell adhesion 0.00492517895950389 748 50 9 0.18 0.0120320855614973
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 0.00492517895950389 192 11 3 0.272727272727273 0.015625
GO:BP GO:0034341 response to interferon-gamma 0.00515702309077417 196 11 3 0.272727272727273 0.0153061224489796
GO:BP GO:0032729 positive regulation of interferon-gamma production 0.00654862804108247 66 34 3 0.0882352941176471 0.0454545454545455
GO:BP GO:0042110 T cell activation 0.00664334535329905 489 34 6 0.176470588235294 0.0122699386503067
GO:BP GO:0002253 activation of immune response 0.00664334535329905 568 11 4 0.363636363636364 0.00704225352112676
GO:BP GO:0002260 lymphocyte homeostasis 0.00696982413951893 61 38 3 0.0789473684210526 0.0491803278688525
GO:BP GO:0042278 purine nucleoside metabolic process 0.00748378027434468 65 37 3 0.0810810810810811 0.0461538461538462
GO:BP GO:0071345 cellular response to cytokine stimulus 0.00748378027434468 1132 11 5 0.454545454545455 0.00441696113074205
GO:BP GO:0050670 regulation of lymphocyte proliferation 0.00748378027434468 230 11 3 0.272727272727273 0.0130434782608696
GO:BP GO:0032944 regulation of mononuclear cell proliferation 0.00748378027434468 232 11 3 0.272727272727273 0.0129310344827586
GO:BP GO:0046651 lymphocyte proliferation 0.00810391357118349 294 38 5 0.131578947368421 0.0170068027210884
GO:BP GO:0010628 positive regulation of gene expression 0.00810391357118349 1160 11 5 0.454545454545455 0.00431034482758621
GO:BP GO:0032943 mononuclear cell proliferation 0.00830442044778886 297 38 5 0.131578947368421 0.0168350168350168
GO:BP GO:0070663 regulation of leukocyte proliferation 0.0088917507179307 251 11 3 0.272727272727273 0.0119521912350598
GO:BP GO:0070228 regulation of lymphocyte apoptotic process 0.0096245102848463 55 49 3 0.0612244897959184 0.0545454545454545
GO:BP GO:0034097 response to cytokine 0.00982013613390033 1226 11 5 0.454545454545455 0.00407830342577488
GO:BP GO:0070661 leukocyte proliferation 0.0117327817898473 325 38 5 0.131578947368421 0.0153846153846154
GO:BP GO:0045582 positive regulation of T cell differentiation 0.0136807707185589 91 34 3 0.0882352941176471 0.032967032967033
GO:BP GO:0043299 leukocyte degranulation 0.0143089515429575 535 66 8 0.121212121212121 0.0149532710280374
GO:BP GO:0031532 actin cytoskeleton reorganization 0.0144655091018691 106 69 4 0.0579710144927536 0.0377358490566038
GO:BP GO:0001776 leukocyte homeostasis 0.0153307540702926 86 38 3 0.0789473684210526 0.0348837209302326
GO:BP GO:0048583 regulation of response to stimulus 0.0154360770020651 4278 11 8 0.727272727272727 0.0018700327255727
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0157271746836536 547 66 8 0.121212121212121 0.0146252285191956
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0161734682000442 551 66 8 0.121212121212121 0.014519056261343
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.0178974194887198 549 26 5 0.192307692307692 0.00910746812386157
GO:BP GO:0045621 positive regulation of lymphocyte differentiation 0.0178974194887198 104 34 3 0.0882352941176471 0.0288461538461538
GO:BP GO:0042102 positive regulation of T cell proliferation 0.0178974194887198 104 34 3 0.0882352941176471 0.0288461538461538
GO:BP GO:0001817 regulation of cytokine production 0.0180241641041686 806 11 4 0.363636363636364 0.00496277915632754
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.018198034799911 810 11 4 0.363636363636364 0.00493827160493827
GO:BP GO:0070227 lymphocyte apoptotic process 0.0186764293590268 74 49 3 0.0612244897959184 0.0405405405405405
GO:BP GO:0032649 regulation of interferon-gamma production 0.0194630823473888 110 34 3 0.0882352941176471 0.0272727272727273
GO:BP GO:0001816 cytokine production 0.0201478816020645 844 11 4 0.363636363636364 0.004739336492891
GO:BP GO:0048584 positive regulation of response to stimulus 0.0202565954273457 2344 11 6 0.545454545454545 0.00255972696245734
GO:BP GO:0032609 interferon-gamma production 0.0213931451759972 115 34 3 0.0882352941176471 0.0260869565217391
GO:BP GO:0009116 nucleoside metabolic process 0.0215596238630842 107 37 3 0.0810810810810811 0.0280373831775701
GO:BP GO:2000106 regulation of leukocyte apoptotic process 0.022538365065681 82 49 3 0.0612244897959184 0.0365853658536585
GO:BP GO:0002285 lymphocyte activation involved in immune response 0.0251281733485702 190 49 4 0.0816326530612245 0.0210526315789474
GO:BP GO:0002283 neutrophil activation involved in immune response 0.0261667565848873 485 66 7 0.106060606060606 0.0144329896907217
GO:BP GO:0043312 neutrophil degranulation 0.0261667565848873 482 66 7 0.106060606060606 0.0145228215767635
GO:BP GO:0050900 leukocyte migration 0.0286446544266483 511 20 4 0.2 0.00782778864970646
GO:BP GO:0002446 neutrophil mediated immunity 0.0287243546171402 497 66 7 0.106060606060606 0.0140845070422535
GO:BP GO:0042119 neutrophil activation 0.0287243546171402 498 66 7 0.106060606060606 0.0140562248995984
GO:BP GO:1901657 glycosyl compound metabolic process 0.0299591196321463 130 37 3 0.0810810810810811 0.0230769230769231
GO:BP GO:0036230 granulocyte activation 0.0299591196321463 504 66 7 0.106060606060606 0.0138888888888889
GO:BP GO:0045580 regulation of T cell differentiation 0.0352114879775222 152 34 3 0.0882352941176471 0.0197368421052632
GO:BP GO:1902107 positive regulation of leukocyte differentiation 0.0367661953086271 157 34 3 0.0882352941176471 0.0191082802547771
GO:BP GO:1903708 positive regulation of hemopoiesis 0.0367661953086271 157 34 3 0.0882352941176471 0.0191082802547771
GO:BP GO:0071887 leukocyte apoptotic process 0.0367661953086271 108 49 3 0.0612244897959184 0.0277777777777778
GO:BP GO:0032675 regulation of interleukin-6 production 0.0408900527928892 168 34 3 0.0882352941176471 0.0178571428571429
GO:BP GO:0009605 response to external stimulus 0.0418338614935519 2944 11 6 0.545454545454545 0.00203804347826087
GO:BP GO:0032635 interleukin-6 production 0.0418749235613843 172 34 3 0.0882352941176471 0.0174418604651163
GO:BP GO:0071346 cellular response to interferon-gamma 0.0433084365679747 175 34 3 0.0882352941176471 0.0171428571428571
GO:BP GO:0051048 negative regulation of secretion 0.0433149864706828 176 34 3 0.0882352941176471 0.0170454545454545
GO:BP GO:0042129 regulation of T cell proliferation 0.0433149864706828 176 34 3 0.0882352941176471 0.0170454545454545
GO:BP GO:0045619 regulation of lymphocyte differentiation 0.0450302353336572 180 34 3 0.0882352941176471 0.0166666666666667
GO:BP GO:0006950 response to stress 0.0450302353336572 4170 11 7 0.636363636363636 0.00167865707434053
GO:BP GO:0009615 response to virus 0.0487502840099487 364 35 4 0.114285714285714 0.010989010989011
GO:BP GO:0002695 negative regulation of leukocyte activation 0.049102676225431 188 34 3 0.0882352941176471 0.0159574468085106
GO:CC GO:0042613 MHC class II protein complex 1.81471817445869e-07 16 17 4 0.235294117647059 0.25
GO:CC GO:0042611 MHC protein complex 5.27436649755486e-07 24 17 4 0.235294117647059 0.166666666666667
GO:CC GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 1.88303079366152e-05 25 11 3 0.272727272727273 0.12
GO:CC GO:0098553 lumenal side of endoplasmic reticulum membrane 1.88303079366152e-05 25 11 3 0.272727272727273 0.12
GO:CC GO:0098552 side of membrane 2.15586803232106e-05 619 11 6 0.545454545454545 0.00969305331179321
GO:CC GO:0098576 lumenal side of membrane 2.97038176538947e-05 33 11 3 0.272727272727273 0.0909090909090909
GO:CC GO:0030669 clathrin-coated endocytic vesicle membrane 3.32871509912686e-05 36 11 3 0.272727272727273 0.0833333333333333
GO:CC GO:0045334 clathrin-coated endocytic vesicle 8.98619267258713e-05 54 11 3 0.272727272727273 0.0555555555555556
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 8.98619267258713e-05 158 14 4 0.285714285714286 0.0253164556962025
GO:CC GO:0012507 ER to Golgi transport vesicle membrane 8.98619267258713e-05 57 11 3 0.272727272727273 0.0526315789473684
GO:CC GO:0009986 cell surface 8.98619267258713e-05 899 11 6 0.545454545454545 0.00667408231368187
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 0.000100213206936805 166 14 4 0.285714285714286 0.0240963855421687
GO:CC GO:0016021 integral component of membrane 0.000247884973167406 5711 55 32 0.581818181818182 0.00560322185256523
GO:CC GO:0030134 COPII-coated ER to Golgi transport vesicle 0.000251255749664292 90 11 3 0.272727272727273 0.0333333333333333
GO:CC GO:0032588 trans-Golgi network membrane 0.00026842304010085 94 11 3 0.272727272727273 0.0319148936170213
GO:CC GO:0000323 lytic vacuole 0.000300510128344281 712 17 6 0.352941176470588 0.00842696629213483
GO:CC GO:0005764 lysosome 0.000300510128344281 712 17 6 0.352941176470588 0.00842696629213483
GO:CC GO:0031224 intrinsic component of membrane 0.00031266587948551 5868 55 32 0.581818181818182 0.005453306066803
GO:CC GO:0030665 clathrin-coated vesicle membrane 0.00038278692801314 114 11 3 0.272727272727273 0.0263157894736842
GO:CC GO:0009897 external side of plasma membrane 0.000420906644831505 408 4 3 0.75 0.00735294117647059
GO:CC GO:0005773 vacuole 0.000508274544252217 810 17 6 0.352941176470588 0.00740740740740741
GO:CC GO:0071944 cell periphery 0.00063587065793531 6169 57 33 0.578947368421053 0.00534932728156914
GO:CC GO:0030666 endocytic vesicle membrane 0.000764138554803589 159 11 3 0.272727272727273 0.0188679245283019
GO:CC GO:0005886 plasma membrane 0.000824849602203294 5681 57 31 0.543859649122807 0.00545678577715191
GO:CC GO:0030662 coated vesicle membrane 0.000977743358476495 177 11 3 0.272727272727273 0.0169491525423729
GO:CC GO:0031301 integral component of organelle membrane 0.0010468772559362 382 14 4 0.285714285714286 0.0104712041884817
GO:CC GO:0030136 clathrin-coated vesicle 0.00107721869703685 193 11 3 0.272727272727273 0.0155440414507772
GO:CC GO:0031300 intrinsic component of organelle membrane 0.00121134985855651 413 14 4 0.285714285714286 0.00968523002421308
GO:CC GO:0030658 transport vesicle membrane 0.00128694396855626 209 11 3 0.272727272727273 0.0143540669856459
GO:CC GO:0005765 lysosomal membrane 0.00189187855905685 383 17 4 0.235294117647059 0.010443864229765
GO:CC GO:0098852 lytic vacuole membrane 0.00189187855905685 383 17 4 0.235294117647059 0.010443864229765
GO:CC GO:0005802 trans-Golgi network 0.0020116176824265 250 11 3 0.272727272727273 0.012
GO:CC GO:0031982 vesicle 0.00217248571993981 4055 11 8 0.727272727272727 0.00197287299630086
GO:CC GO:0005774 vacuolar membrane 0.00291977374543674 441 17 4 0.235294117647059 0.0090702947845805
GO:CC GO:0030135 coated vesicle 0.00296050915175475 295 11 3 0.272727272727273 0.0101694915254237
GO:CC GO:0030139 endocytic vesicle 0.00321898154508971 306 11 3 0.272727272727273 0.00980392156862745
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.00373458928872545 779 11 4 0.363636363636364 0.00513478818998716
GO:CC GO:0031226 intrinsic component of plasma membrane 0.0039526995017748 1726 60 14 0.233333333333333 0.00811123986095017
GO:CC GO:0012506 vesicle membrane 0.0039526995017748 800 11 4 0.363636363636364 0.005
GO:CC GO:0030133 transport vesicle 0.00693379085678406 414 11 3 0.272727272727273 0.0072463768115942
GO:CC GO:0098797 plasma membrane protein complex 0.0126318920249582 694 17 4 0.235294117647059 0.00576368876080692
GO:CC GO:0016020 membrane 0.0135480451063957 9838 55 39 0.709090909090909 0.0039642203699939
GO:CC GO:0097708 intracellular vesicle 0.0139146200926672 2428 17 7 0.411764705882353 0.0028830313014827
GO:CC GO:0031410 cytoplasmic vesicle 0.0139146200926672 2424 17 7 0.411764705882353 0.00288778877887789
GO:CC GO:0032580 Golgi cisterna membrane 0.0148079686986291 90 65 3 0.0461538461538462 0.0333333333333333
GO:CC GO:0005775 vacuolar lumen 0.0159593132497874 174 35 3 0.0857142857142857 0.0172413793103448
GO:CC GO:0005887 integral component of plasma membrane 0.0189811756537973 1645 60 12 0.2 0.00729483282674772
GO:CC GO:0070062 extracellular exosome 0.0212385704723581 2176 4 3 0.75 0.00137867647058824
GO:CC GO:1903561 extracellular vesicle 0.0230201926648076 2261 4 3 0.75 0.00132684652808492
GO:CC GO:0043230 extracellular organelle 0.0230201926648076 2263 4 3 0.75 0.00132567388422448
GO:CC GO:0031985 Golgi cisterna 0.0264235074897037 115 65 3 0.0461538461538462 0.0260869565217391
GO:CC GO:0005789 endoplasmic reticulum membrane 0.0264235074897037 1117 14 4 0.285714285714286 0.0035810205908684
GO:CC GO:0098827 endoplasmic reticulum subcompartment 0.0264291878569586 1122 14 4 0.285714285714286 0.0035650623885918
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 0.0274414088266856 1139 14 4 0.285714285714286 0.00351185250219491
GO:CC GO:0042582 azurophil granule 0.0281545236919154 154 52 3 0.0576923076923077 0.0194805194805195
GO:CC GO:0005766 primary lysosome 0.0281545236919154 154 52 3 0.0576923076923077 0.0194805194805195
GO:CC GO:0000139 Golgi membrane 0.0281545236919154 771 11 3 0.272727272727273 0.00389105058365759
GO:CC GO:0010008 endosome membrane 0.0304890012637529 505 17 3 0.176470588235294 0.00594059405940594
GO:CC GO:0005768 endosome 0.0313431972038034 987 17 4 0.235294117647059 0.00405268490374873
GO:CC GO:0030667 secretory granule membrane 0.0348404123097075 303 55 4 0.0727272727272727 0.0132013201320132
GO:CC GO:0098791 Golgi apparatus subcompartment 0.0372035832462359 885 11 3 0.272727272727273 0.00338983050847458
GO:CC GO:0005576 extracellular region 0.0387848322504429 4567 5 4 0.8 0.000875848478213269
GO:CC GO:0005795 Golgi stack 0.0403211359424194 149 65 3 0.0461538461538462 0.0201342281879195
GO:MF GO:0003823 antigen binding 0.000563054995846934 163 11 4 0.363636363636364 0.0245398773006135
GO:MF GO:0042277 peptide binding 0.0288534670186297 314 11 3 0.272727272727273 0.00955414012738853
GO:MF GO:0033218 amide binding 0.0348393714468275 389 11 3 0.272727272727273 0.0077120822622108
GO:MF GO:0005102 signaling receptor binding 0.0353394731205825 1672 4 3 0.75 0.00179425837320574
GO:MF GO:0030246 carbohydrate binding 0.0353394731205825 275 41 4 0.0975609756097561 0.0145454545454545
KEGG KEGG:04612 Antigen processing and presentation 0.000864178039426646 69 17 4 0.235294117647059 0.0579710144927536
KEGG KEGG:05310 Asthma 0.000880817852876264 27 17 3 0.176470588235294 0.111111111111111
KEGG KEGG:05330 Allograft rejection 0.000892743840893456 34 17 3 0.176470588235294 0.0882352941176471
KEGG KEGG:04640 Hematopoietic cell lineage 0.000892743840893456 95 17 4 0.235294117647059 0.0421052631578947
KEGG KEGG:05332 Graft-versus-host disease 0.000923706632711454 37 17 3 0.176470588235294 0.0810810810810811
KEGG KEGG:04940 Type I diabetes mellitus 0.000974936803641245 40 17 3 0.176470588235294 0.075
KEGG KEGG:04672 Intestinal immune network for IgA production 0.00119234301436601 45 17 3 0.176470588235294 0.0666666666666667
KEGG KEGG:05320 Autoimmune thyroid disease 0.00134749622109629 49 17 3 0.176470588235294 0.0612244897959184
KEGG KEGG:05416 Viral myocarditis 0.00164176093777958 56 17 3 0.176470588235294 0.0535714285714286
KEGG KEGG:04514 Cell adhesion molecules 0.00164176093777958 146 17 4 0.235294117647059 0.0273972602739726
KEGG KEGG:05321 Inflammatory bowel disease 0.00197761297811495 62 17 3 0.176470588235294 0.0483870967741935
KEGG KEGG:05152 Tuberculosis 0.00260433916072132 175 17 4 0.235294117647059 0.0228571428571429
KEGG KEGG:05140 Leishmaniasis 0.00260433916072132 72 17 3 0.176470588235294 0.0416666666666667
KEGG KEGG:05150 Staphylococcus aureus infection 0.00370841398899523 87 17 3 0.176470588235294 0.0344827586206897
KEGG KEGG:05169 Epstein-Barr virus infection 0.00370841398899523 198 17 4 0.235294117647059 0.0202020202020202
KEGG KEGG:04658 Th1 and Th2 cell differentiation 0.00370841398899523 89 17 3 0.176470588235294 0.0337078651685393
KEGG KEGG:05323 Rheumatoid arthritis 0.00370841398899523 88 17 3 0.176470588235294 0.0340909090909091
KEGG KEGG:04659 Th17 cell differentiation 0.00550652338216522 104 17 3 0.176470588235294 0.0288461538461538
KEGG KEGG:05145 Toxoplasmosis 0.00597453567954449 109 17 3 0.176470588235294 0.0275229357798165
KEGG KEGG:05322 Systemic lupus erythematosus 0.00982755868261808 132 17 3 0.176470588235294 0.0227272727272727
KEGG KEGG:04145 Phagosome 0.0127039155422279 147 17 3 0.176470588235294 0.0204081632653061
KEGG KEGG:05164 Influenza A 0.0179490061984815 169 17 3 0.176470588235294 0.0177514792899408
KEGG KEGG:05166 Human T-cell leukemia virus 1 infection 0.0338279517089017 216 17 3 0.176470588235294 0.0138888888888889
REAC REAC:R-HSA-1280218 Adaptive Immune System 0.00196518177189611 800 20 9 0.45 0.01125
REAC REAC:R-HSA-168256 Immune System 0.00275113548394955 2139 20 13 0.65 0.00607760635811127
REAC REAC:R-HSA-2132295 MHC class II antigen presentation 0.00849738115892514 123 11 3 0.272727272727273 0.024390243902439
REAC REAC:R-HSA-388841 Costimulation by the CD28 family 0.00849738115892514 67 18 3 0.166666666666667 0.0447761194029851
REAC REAC:R-HSA-202733 Cell surface interactions at the vascular wall 0.0165307551986912 190 10 3 0.3 0.0157894736842105
REAC REAC:R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.0375026448437679 181 73 6 0.0821917808219178 0.0331491712707182
TF TF:M04235 Factor: FOXC2; motif: NGTMAATATTKACN 0.049329168938961 472 13 5 0.384615384615385 0.0105932203389831

pB10 transcription factor target enrichment of top program genes

TF enrichment of pB10
TFs corrosponding to activation of pB10. (Left) pearson correlation of TF expression and gene expression program activatity in B cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.