pEpiTd09 program activity among Epithelial cells

Activation of pEpiTd09
pEpiTd09 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTd09 by different cell subtypes
pEpiTd09 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTd09 top program genes

Top genes of pEpiTd09 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTd09 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTd09
pEpiTd09 gene-set enrichment summary using g-profiler webtool.

pEpiTd09 transcription factor target enrichment of top program genes

TF enrichment of pEpiTd09
Possible regulators of activation of pEpiTd09 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.