pM15 program activity among Myeloid cells

Activation of pM15
pM15 gene program activation in Myeloid cells.
Gene program activation of pM15 by different cell subtypes
pM15 gene program activation among cells of different subtypes (Myeloid cells).

pM15 top program genes

Top genes of pM15 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pM15 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pM15
pM15 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002274 myeloid leukocyte activation 9.30003164617628e-06 667 61 15 0.245901639344262 0.0224887556221889
GO:BP GO:0002376 immune system process 1.06373617896876e-05 3278 71 34 0.47887323943662 0.0103721781574131
GO:BP GO:0002446 neutrophil mediated immunity 1.63882198013922e-05 497 71 13 0.183098591549296 0.0261569416498994
GO:BP GO:0036230 granulocyte activation 1.63882198013922e-05 504 71 13 0.183098591549296 0.0257936507936508
GO:BP GO:0042119 neutrophil activation 1.63882198013922e-05 498 71 13 0.183098591549296 0.0261044176706827
GO:BP GO:0002283 neutrophil activation involved in immune response 1.63882198013922e-05 485 71 13 0.183098591549296 0.0268041237113402
GO:BP GO:0043312 neutrophil degranulation 1.63882198013922e-05 482 71 13 0.183098591549296 0.0269709543568465
GO:BP GO:0045055 regulated exocytosis 1.63882198013922e-05 785 61 15 0.245901639344262 0.0191082802547771
GO:BP GO:0006955 immune response 1.63882198013922e-05 2311 71 27 0.380281690140845 0.0116832540025963
GO:BP GO:0001775 cell activation 1.63882198013922e-05 1495 71 22 0.309859154929577 0.0147157190635452
GO:BP GO:0043299 leukocyte degranulation 2.97358147686334e-05 535 71 13 0.183098591549296 0.0242990654205607
GO:BP GO:0032940 secretion by cell 3.01327030250716e-05 1364 71 20 0.28169014084507 0.0146627565982405
GO:BP GO:0046903 secretion 3.01327030250716e-05 1501 71 21 0.295774647887324 0.0139906728847435
GO:BP GO:0002275 myeloid cell activation involved in immune response 3.01563768102124e-05 547 71 13 0.183098591549296 0.0237659963436929
GO:BP GO:0002444 myeloid leukocyte mediated immunity 3.0601018522394e-05 551 71 13 0.183098591549296 0.0235934664246824
GO:BP GO:0006887 exocytosis 3.2330182815314e-05 904 61 15 0.245901639344262 0.0165929203539823
GO:BP GO:0140352 export from cell 4.31447654784587e-05 1418 71 20 0.28169014084507 0.0141043723554302
GO:BP GO:0045321 leukocyte activation 7.36502985437909e-05 1332 71 19 0.267605633802817 0.0142642642642643
GO:BP GO:0002366 leukocyte activation involved in immune response 7.64934714680373e-05 717 71 14 0.197183098591549 0.0195258019525802
GO:BP GO:0002263 cell activation involved in immune response 7.7666938318323e-05 721 71 14 0.197183098591549 0.0194174757281553
GO:BP GO:0001817 regulation of cytokine production 0.000230873378991774 806 70 14 0.2 0.0173697270471464
GO:BP GO:0001816 cytokine production 0.000377003047440101 844 70 14 0.2 0.0165876777251185
GO:BP GO:0007165 signal transduction 0.000405019342333439 6309 78 47 0.602564102564103 0.00744967506736408
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.000443530833303541 810 95 16 0.168421052631579 0.0197530864197531
GO:BP GO:0002443 leukocyte mediated immunity 0.000615031259500129 877 71 14 0.197183098591549 0.015963511972634
GO:BP GO:0050896 response to stimulus 0.000733321111200752 9407 71 55 0.774647887323944 0.0058467098968853
GO:BP GO:0002252 immune effector process 0.000785602649841197 1309 71 17 0.23943661971831 0.012987012987013
GO:BP GO:0002526 acute inflammatory response 0.00102990459371157 114 23 4 0.173913043478261 0.0350877192982456
GO:BP GO:0035556 intracellular signal transduction 0.00121603463876428 2772 94 31 0.329787234042553 0.0111832611832612
GO:BP GO:0007154 cell communication 0.00129728263460582 6829 78 48 0.615384615384615 0.0070288475618685
GO:BP GO:0009605 response to external stimulus 0.00144617432610152 2944 66 25 0.378787878787879 0.00849184782608696
GO:BP GO:0048583 regulation of response to stimulus 0.00150524379617854 4278 71 33 0.464788732394366 0.00771388499298738
GO:BP GO:0006950 response to stress 0.00170183288095851 4170 70 32 0.457142857142857 0.00767386091127098
GO:BP GO:0023052 signaling 0.00279400634157982 6810 78 47 0.602564102564103 0.00690161527165932
GO:BP GO:0040011 locomotion 0.00305699026300586 2028 91 24 0.263736263736264 0.0118343195266272
GO:BP GO:0007568 aging 0.00314322956373419 329 12 4 0.333333333333333 0.0121580547112462
GO:BP GO:0051716 cellular response to stimulus 0.00329865792671442 7781 78 51 0.653846153846154 0.00655442745148439
GO:BP GO:0016192 vesicle-mediated transport 0.00372657804453177 2180 71 21 0.295774647887324 0.00963302752293578
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.00382208306206947 549 24 6 0.25 0.0109289617486339
GO:BP GO:1901741 positive regulation of myoblast fusion 0.00383601539321964 16 91 3 0.032967032967033 0.1875
GO:BP GO:0031396 regulation of protein ubiquitination 0.00590459018990069 211 93 7 0.0752688172043011 0.033175355450237
GO:BP GO:0019220 regulation of phosphate metabolic process 0.00590459018990069 1645 82 19 0.231707317073171 0.0115501519756839
GO:BP GO:0051174 regulation of phosphorus metabolic process 0.00590459018990069 1645 82 19 0.231707317073171 0.0115501519756839
GO:BP GO:1901739 regulation of myoblast fusion 0.00598198084686433 19 91 3 0.032967032967033 0.157894736842105
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.00658391856364873 2541 93 27 0.290322580645161 0.0106257378984652
GO:BP GO:0006952 defense response 0.0067866614483768 1818 70 18 0.257142857142857 0.0099009900990099
GO:BP GO:0051246 regulation of protein metabolic process 0.00680477093570641 2704 93 28 0.301075268817204 0.0103550295857988
GO:BP GO:1902531 regulation of intracellular signal transduction 0.00680477093570641 1842 94 22 0.234042553191489 0.011943539630836
GO:BP GO:0002675 positive regulation of acute inflammatory response 0.00714614694282479 29 66 3 0.0454545454545455 0.103448275862069
GO:BP GO:0071310 cellular response to organic substance 0.00852499343856645 2776 70 23 0.328571428571429 0.00828530259365994
GO:BP GO:0048870 cell motility 0.00920228017897664 1828 91 21 0.230769230769231 0.0114879649890591
GO:BP GO:0051674 localization of cell 0.00920228017897664 1828 91 21 0.230769230769231 0.0114879649890591
GO:BP GO:0006954 inflammatory response 0.00920228017897664 794 70 11 0.157142857142857 0.0138539042821159
GO:BP GO:0060143 positive regulation of syncytium formation by plasma membrane fusion 0.00920228017897664 24 91 3 0.032967032967033 0.125
GO:BP GO:0031399 regulation of protein modification process 0.00970117003703442 1671 93 20 0.21505376344086 0.0119688809096349
GO:BP GO:0048585 negative regulation of response to stimulus 0.00970117003703442 1733 25 9 0.36 0.0051933064050779
GO:BP GO:0071345 cellular response to cytokine stimulus 0.00970117003703442 1132 95 16 0.168421052631579 0.0141342756183746
GO:BP GO:1903320 regulation of protein modification by small protein conjugation or removal 0.00970117003703442 243 93 7 0.0752688172043011 0.0288065843621399
GO:BP GO:0060142 regulation of syncytium formation by plasma membrane fusion 0.00970117003703442 27 91 3 0.032967032967033 0.111111111111111
GO:BP GO:0007166 cell surface receptor signaling pathway 0.00970117003703442 3210 86 29 0.337209302325581 0.00903426791277259
GO:BP GO:0002682 regulation of immune system process 0.0101390778061153 1617 70 16 0.228571428571429 0.00989486703772418
GO:BP GO:0048584 positive regulation of response to stimulus 0.0110694849774305 2344 70 20 0.285714285714286 0.00853242320819113
GO:BP GO:0010648 negative regulation of cell communication 0.0111284591134106 1468 24 8 0.333333333333333 0.00544959128065395
GO:BP GO:0023057 negative regulation of signaling 0.0111585670213807 1471 24 8 0.333333333333333 0.00543847722637661
GO:BP GO:0019222 regulation of metabolic process 0.0113352694532707 7148 93 53 0.56989247311828 0.00741466144376049
GO:BP GO:0016477 cell migration 0.0115595643493132 1649 91 19 0.208791208791209 0.0115221346270467
GO:BP GO:1901223 negative regulation of NIK/NF-kappaB signaling 0.0116760380970189 39 71 3 0.0422535211267606 0.0769230769230769
GO:BP GO:0070887 cellular response to chemical stimulus 0.0128627970206644 3393 70 25 0.357142857142857 0.00736811081638668
GO:BP GO:0034097 response to cytokine 0.0129147211272743 1226 95 16 0.168421052631579 0.0130505709624796
GO:BP GO:0010033 response to organic substance 0.0136032879549819 3412 70 25 0.357142857142857 0.00732708089097304
GO:BP GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 0.0138630722111865 36 87 3 0.0344827586206897 0.0833333333333333
GO:BP GO:0065008 regulation of biological quality 0.0140938176748084 4131 21 12 0.571428571428571 0.00290486564996369
GO:BP GO:0002684 positive regulation of immune system process 0.0143813723876786 1065 70 12 0.171428571428571 0.0112676056338028
GO:BP GO:0002673 regulation of acute inflammatory response 0.0158980185877921 50 66 3 0.0454545454545455 0.06
GO:BP GO:0051239 regulation of multicellular organismal process 0.0160729772936354 2861 70 22 0.314285714285714 0.00768961901433065
GO:BP GO:0002237 response to molecule of bacterial origin 0.0163083153199483 361 56 6 0.107142857142857 0.0166204986149584
GO:BP GO:0042221 response to chemical 0.0173829676299025 4781 70 31 0.442857142857143 0.00648399916335495
GO:BP GO:0048519 negative regulation of biological process 0.0174878458280609 5757 25 16 0.64 0.00277922529095015
GO:BP GO:0060326 cell chemotaxis 0.0180032775895358 310 91 7 0.0769230769230769 0.0225806451612903
GO:BP GO:0070498 interleukin-1-mediated signaling pathway 0.0192521433683488 105 77 4 0.051948051948052 0.0380952380952381
GO:BP GO:0031401 positive regulation of protein modification process 0.0197726197207778 1074 93 14 0.150537634408602 0.0130353817504655
GO:BP GO:0065009 regulation of molecular function 0.0202583647019411 3221 93 29 0.311827956989247 0.00900341508848184
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.0203287027188248 1455 70 14 0.2 0.00962199312714777
GO:BP GO:0002720 positive regulation of cytokine production involved in immune response 0.0204140137015021 54 70 3 0.0428571428571429 0.0555555555555556
GO:BP GO:0007520 myoblast fusion 0.0208063253366929 42 91 3 0.032967032967033 0.0714285714285714
GO:BP GO:0010038 response to metal ion 0.0221704648268376 371 24 4 0.166666666666667 0.0107816711590297
GO:BP GO:0010646 regulation of cell communication 0.0236145100429187 3543 94 31 0.329787234042553 0.0087496471916455
GO:BP GO:0009968 negative regulation of signal transduction 0.0236145100429187 1364 52 11 0.211538461538462 0.00806451612903226
GO:BP GO:1903321 negative regulation of protein modification by small protein conjugation or removal 0.0244668953628094 96 93 4 0.043010752688172 0.0416666666666667
GO:BP GO:0031343 positive regulation of cell killing 0.0246298254859752 59 70 3 0.0428571428571429 0.0508474576271186
GO:BP GO:0051100 negative regulation of binding 0.0253065806233828 163 56 4 0.0714285714285714 0.0245398773006135
GO:BP GO:0006935 chemotaxis 0.0253065806233828 653 91 10 0.10989010989011 0.0153139356814701
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.0257279214387563 3087 77 24 0.311688311688312 0.00777453838678328
GO:BP GO:0042330 taxis 0.0257279214387563 656 91 10 0.10989010989011 0.0152439024390244
GO:BP GO:0023051 regulation of signaling 0.0257399203183043 3578 94 31 0.329787234042553 0.00866405813303522
GO:BP GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 0.0257399203183043 55 78 3 0.0384615384615385 0.0545454545454545
GO:BP GO:0001819 positive regulation of cytokine production 0.0257732792339184 452 70 7 0.1 0.0154867256637168
GO:BP GO:0042325 regulation of phosphorylation 0.0257732792339184 1431 82 15 0.182926829268293 0.010482180293501
GO:BP GO:1901799 negative regulation of proteasomal protein catabolic process 0.0257732792339184 50 87 3 0.0344827586206897 0.06
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 0.0257732792339184 1001 82 12 0.146341463414634 0.011988011988012
GO:BP GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 0.0257732792339184 50 87 3 0.0344827586206897 0.06
GO:BP GO:0045937 positive regulation of phosphate metabolic process 0.0257732792339184 1001 82 12 0.146341463414634 0.011988011988012
GO:BP GO:0009617 response to bacterium 0.0266470104115523 743 56 8 0.142857142857143 0.0107671601615074
GO:BP GO:0080090 regulation of primary metabolic process 0.0266470104115523 6053 93 45 0.483870967741935 0.00743433008425574
GO:BP GO:0006793 phosphorus metabolic process 0.0266470104115523 3114 77 24 0.311688311688312 0.00770712909441233
GO:BP GO:0071248 cellular response to metal ion 0.026860453656912 192 24 3 0.125 0.015625
GO:BP GO:0045936 negative regulation of phosphate metabolic process 0.0280817887152784 543 45 6 0.133333333333333 0.0110497237569061
GO:BP GO:0045861 negative regulation of proteolysis 0.0281146032165596 359 91 7 0.0769230769230769 0.0194986072423398
GO:BP GO:0010563 negative regulation of phosphorus metabolic process 0.0281146032165596 544 45 6 0.133333333333333 0.0110294117647059
GO:BP GO:0009966 regulation of signal transduction 0.0285707906202696 3165 94 28 0.297872340425532 0.00884676145339653
GO:BP GO:0034341 response to interferon-gamma 0.0298611869482884 196 25 3 0.12 0.0153061224489796
GO:BP GO:1990266 neutrophil migration 0.0298611869482884 124 39 3 0.0769230769230769 0.0241935483870968
GO:BP GO:0050776 regulation of immune response 0.0302529633871732 996 44 8 0.181818181818182 0.00803212851405622
GO:BP GO:1901222 regulation of NIK/NF-kappaB signaling 0.0308180459133473 113 91 4 0.043956043956044 0.0353982300884956
GO:BP GO:0000768 syncytium formation by plasma membrane fusion 0.0318228892413409 55 91 3 0.032967032967033 0.0545454545454545
GO:BP GO:0140253 cell-cell fusion 0.0318228892413409 55 91 3 0.032967032967033 0.0545454545454545
GO:BP GO:0051707 response to other organism 0.0326722572117869 1592 70 14 0.2 0.00879396984924623
GO:BP GO:0043207 response to external biotic stimulus 0.0328890454712617 1594 70 14 0.2 0.00878293601003764
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 0.0345129914127853 80 65 3 0.0461538461538462 0.0375
GO:BP GO:0071241 cellular response to inorganic substance 0.0345129914127853 220 24 3 0.125 0.0136363636363636
GO:BP GO:0006949 syncytium formation 0.0345129914127853 57 91 3 0.032967032967033 0.0526315789473684
GO:BP GO:0030168 platelet activation 0.0355287859957772 160 68 4 0.0588235294117647 0.025
GO:BP GO:0009607 response to biotic stimulus 0.0379506612703615 1626 70 14 0.2 0.00861008610086101
GO:BP GO:0032091 negative regulation of protein binding 0.0379696811621692 97 56 3 0.0535714285714286 0.0309278350515464
GO:BP GO:0031398 positive regulation of protein ubiquitination 0.0381160651106092 120 93 4 0.043010752688172 0.0333333333333333
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.0382728865430212 1082 93 13 0.139784946236559 0.0120147874306839
GO:BP GO:0046879 hormone secretion 0.03855130316555 317 18 3 0.166666666666667 0.00946372239747634
GO:BP GO:0001932 regulation of protein phosphorylation 0.0389732868360863 1240 82 13 0.158536585365854 0.0104838709677419
GO:BP GO:0007265 Ras protein signal transduction 0.0393038392352901 349 77 6 0.0779220779220779 0.0171919770773639
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.0393062208495452 6603 93 47 0.505376344086022 0.00711797667726791
GO:BP GO:0006513 protein monoubiquitination 0.0393426516148055 67 84 3 0.0357142857142857 0.0447761194029851
GO:BP GO:0044092 negative regulation of molecular function 0.0395706274544523 1219 56 10 0.178571428571429 0.00820344544708778
GO:BP GO:1903706 regulation of hemopoiesis 0.0395706274544523 424 45 5 0.111111111111111 0.0117924528301887
GO:BP GO:0032496 response to lipopolysaccharide 0.0395706274544523 338 56 5 0.0892857142857143 0.014792899408284
GO:BP GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 0.0395706274544523 148 78 4 0.0512820512820513 0.027027027027027
GO:BP GO:0009914 hormone transport 0.0395706274544523 327 18 3 0.166666666666667 0.00917431192660551
GO:BP GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 0.0397243196735953 134 87 4 0.0459770114942529 0.0298507462686567
GO:BP GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 0.0397243196735953 66 87 3 0.0344827586206897 0.0454545454545455
GO:BP GO:0030029 actin filament-based process 0.0399206545202113 808 58 8 0.137931034482759 0.0099009900990099
GO:BP GO:0002262 myeloid cell homeostasis 0.0403164973670348 151 39 3 0.0769230769230769 0.0198675496688742
GO:BP GO:0050790 regulation of catalytic activity 0.0403164973670348 2545 93 23 0.247311827956989 0.00903732809430255
GO:BP GO:0097530 granulocyte migration 0.0403164973670348 151 39 3 0.0769230769230769 0.0198675496688742
GO:BP GO:0051649 establishment of localization in cell 0.0403164973670348 2813 61 18 0.295081967213115 0.00639886242445787
GO:BP GO:0019216 regulation of lipid metabolic process 0.0410374891249207 419 88 7 0.0795454545454545 0.0167064439140811
GO:BP GO:0002718 regulation of cytokine production involved in immune response 0.041304858417828 85 70 3 0.0428571428571429 0.0352941176470588
GO:BP GO:0051130 positive regulation of cellular component organization 0.0417478401568824 1153 70 11 0.157142857142857 0.00954032957502168
GO:BP GO:0006928 movement of cell or subcellular component 0.0419566887919513 2311 91 21 0.230769230769231 0.00908697533535266
GO:BP GO:0001934 positive regulation of protein phosphorylation 0.0419566887919513 840 82 10 0.121951219512195 0.0119047619047619
GO:BP GO:0042592 homeostatic process 0.0428134457844538 1981 4 3 0.75 0.00151438667339727
GO:BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 0.0431809726008193 434 87 7 0.0804597701149425 0.0161290322580645
GO:BP GO:0032970 regulation of actin filament-based process 0.0439568274973662 406 50 5 0.1 0.0123152709359606
GO:BP GO:0040029 regulation of gene expression, epigenetic 0.0440313575749535 206 31 3 0.0967741935483871 0.0145631067961165
GO:BP GO:0009306 protein secretion 0.0440313575749535 384 17 3 0.176470588235294 0.0078125
GO:BP GO:0035592 establishment of protein localization to extracellular region 0.0441941199255677 385 17 3 0.176470588235294 0.00779220779220779
GO:BP GO:0009893 positive regulation of metabolic process 0.0447709443778839 3783 84 28 0.333333333333333 0.00740153317472905
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 0.0452820229853405 99 65 3 0.0461538461538462 0.0303030303030303
GO:BP GO:0071692 protein localization to extracellular region 0.0453406036992177 392 17 3 0.176470588235294 0.0076530612244898
GO:BP GO:0031341 regulation of cell killing 0.045914324264839 93 70 3 0.0428571428571429 0.032258064516129
GO:BP GO:0051247 positive regulation of protein metabolic process 0.0461214464273423 1564 93 16 0.172043010752688 0.010230179028133
GO:BP GO:0002367 cytokine production involved in immune response 0.0461214464273423 94 70 3 0.0428571428571429 0.0319148936170213
GO:BP GO:0002532 production of molecular mediator involved in inflammatory response 0.0461214464273423 94 70 3 0.0428571428571429 0.0319148936170213
GO:BP GO:0030595 leukocyte chemotaxis 0.0461214464273423 227 91 5 0.0549450549450549 0.0220264317180617
GO:BP GO:0006508 proteolysis 0.0462111869181116 1836 94 18 0.191489361702128 0.00980392156862745
GO:BP GO:1903322 positive regulation of protein modification by small protein conjugation or removal 0.0462111869181116 140 93 4 0.043010752688172 0.0285714285714286
GO:BP GO:0050794 regulation of cellular process 0.0462111869181116 11473 79 61 0.772151898734177 0.00531683082018653
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0462111869181116 1151 93 13 0.139784946236559 0.0112945264986968
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 0.0464983636312005 251 83 5 0.0602409638554217 0.0199203187250996
GO:BP GO:0030097 hemopoiesis 0.0469359507995996 928 33 6 0.181818181818182 0.00646551724137931
GO:BP GO:1903363 negative regulation of cellular protein catabolic process 0.0477218780311553 78 87 3 0.0344827586206897 0.0384615384615385
GO:BP GO:0007264 small GTPase mediated signal transduction 0.0477218780311553 515 77 7 0.0909090909090909 0.0135922330097087
GO:BP GO:0043433 negative regulation of DNA-binding transcription factor activity 0.0477218780311553 187 71 4 0.0563380281690141 0.0213903743315508
GO:BP GO:0050789 regulation of biological process 0.0477218780311553 12091 95 75 0.789473684210526 0.00620296087999338
GO:BP GO:0043393 regulation of protein binding 0.0478444613934096 199 67 4 0.0597014925373134 0.0201005025125628
GO:BP GO:0010035 response to inorganic substance 0.0481711983644076 575 24 4 0.166666666666667 0.00695652173913044
GO:BP GO:0016567 protein ubiquitination 0.0481711983644076 892 94 11 0.117021276595745 0.0123318385650224
GO:BP GO:0032677 regulation of interleukin-8 production 0.0488612984072273 99 70 3 0.0428571428571429 0.0303030303030303
GO:BP GO:0002790 peptide secretion 0.0488612984072273 421 17 3 0.176470588235294 0.00712589073634204
GO:BP GO:0097193 intrinsic apoptotic signaling pathway 0.0488612984072273 294 24 3 0.125 0.0102040816326531
GO:BP GO:0002702 positive regulation of production of molecular mediator of immune response 0.048998154227999 100 70 3 0.0428571428571429 0.03
GO:BP GO:0006511 ubiquitin-dependent protein catabolic process 0.048998154227999 655 94 9 0.0957446808510638 0.0137404580152672
GO:BP GO:0032501 multicellular organismal process 0.048998154227999 7946 71 42 0.591549295774648 0.00528567832871885
GO:BP GO:0051179 localization 0.0496563414318193 6901 83 43 0.518072289156627 0.00623098101724388
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.0496563414318193 966 33 6 0.181818181818182 0.0062111801242236
GO:BP GO:0008219 cell death 0.0496563414318193 2292 24 8 0.333333333333333 0.00349040139616056
GO:BP GO:0097190 apoptotic signaling pathway 0.0496563414318193 600 24 4 0.166666666666667 0.00666666666666667
GO:BP GO:0007015 actin filament organization 0.0496563414318193 445 50 5 0.1 0.0112359550561798
GO:BP GO:0019941 modification-dependent protein catabolic process 0.0496563414318193 662 94 9 0.0957446808510638 0.013595166163142
GO:BP GO:0031397 negative regulation of protein ubiquitination 0.0496563414318193 83 87 3 0.0344827586206897 0.036144578313253
GO:BP GO:0022898 regulation of transmembrane transporter activity 0.0496563414318193 281 50 4 0.08 0.0142348754448399
GO:BP GO:0030036 actin cytoskeleton organization 0.0496563414318193 709 58 7 0.120689655172414 0.00987306064880113
GO:BP GO:0031323 regulation of cellular metabolic process 0.049796305962443 6269 93 44 0.473118279569892 0.00701866326367842
GO:BP GO:0009892 negative regulation of metabolic process 0.0497964879474261 3479 93 28 0.301075268817204 0.00804828973843058
GO:BP GO:0032637 interleukin-8 production 0.0498725624240788 104 70 3 0.0428571428571429 0.0288461538461538
GO:BP GO:0051234 establishment of localization 0.0498725624240788 5372 79 34 0.430379746835443 0.00632911392405063
GO:CC GO:0099503 secretory vesicle 9.38553585387222e-05 1020 61 15 0.245901639344262 0.0147058823529412
GO:CC GO:0030141 secretory granule 9.38553585387222e-05 851 61 14 0.229508196721311 0.0164512338425382
GO:CC GO:0034774 secretory granule lumen 0.00221294755250836 320 58 7 0.120689655172414 0.021875
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.00221294755250836 324 58 7 0.120689655172414 0.0216049382716049
GO:CC GO:0031983 vesicle lumen 0.00221294755250836 326 58 7 0.120689655172414 0.0214723926380368
GO:CC GO:0030667 secretory granule membrane 0.00221294755250836 303 86 8 0.0930232558139535 0.0264026402640264
GO:CC GO:0071944 cell periphery 0.00221294755250836 6169 71 39 0.549295774647887 0.00632193224185443
GO:CC GO:0097708 intracellular vesicle 0.00221294755250836 2428 78 23 0.294871794871795 0.00947281713344316
GO:CC GO:0005886 plasma membrane 0.00221294755250836 5681 71 38 0.535211267605634 0.00668896321070234
GO:CC GO:0031410 cytoplasmic vesicle 0.00221294755250836 2424 78 23 0.294871794871795 0.00948844884488449
GO:CC GO:0031901 early endosome membrane 0.00245292060956506 159 29 4 0.137931034482759 0.0251572327044025
GO:CC GO:0070820 tertiary granule 0.00473503308749004 163 34 4 0.117647058823529 0.0245398773006135
GO:CC GO:0055038 recycling endosome membrane 0.00525288747671182 84 29 3 0.103448275862069 0.0357142857142857
GO:CC GO:0098552 side of membrane 0.00525288747671182 619 95 11 0.115789473684211 0.0177705977382876
GO:CC GO:0042581 specific granule 0.00525288747671182 158 71 5 0.0704225352112676 0.0316455696202532
GO:CC GO:0005773 vacuole 0.0141204425086321 810 86 11 0.127906976744186 0.0135802469135802
GO:CC GO:0009897 external side of plasma membrane 0.0141204425086321 408 95 8 0.0842105263157895 0.0196078431372549
GO:CC GO:0000323 lytic vacuole 0.0167669634787998 712 86 10 0.116279069767442 0.0140449438202247
GO:CC GO:0005764 lysosome 0.0167669634787998 712 86 10 0.116279069767442 0.0140449438202247
GO:CC GO:0005912 adherens junction 0.0190913353092951 173 95 5 0.0526315789473684 0.0289017341040462
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.021692481015438 779 34 6 0.176470588235294 0.00770218228498074
GO:CC GO:0031982 vesicle 0.021692481015438 4055 78 28 0.358974358974359 0.00690505548705302
GO:CC GO:0005769 early endosome 0.021692481015438 378 29 4 0.137931034482759 0.0105820105820106
GO:CC GO:0012506 vesicle membrane 0.0219199619943894 800 34 6 0.176470588235294 0.0075
GO:CC GO:0055037 recycling endosome 0.0229218108414378 188 29 3 0.103448275862069 0.0159574468085106
GO:CC GO:0035579 specific granule membrane 0.0338016804642389 90 71 3 0.0422535211267606 0.0333333333333333
GO:CC GO:0009986 cell surface 0.0357762583535812 899 95 11 0.115789473684211 0.0122358175750834
GO:CC GO:0070062 extracellular exosome 0.0370839675301497 2176 77 17 0.220779220779221 0.0078125
GO:CC GO:0005576 extracellular region 0.0381026978653989 4567 58 23 0.396551724137931 0.0050361287497263
GO:CC GO:0010008 endosome membrane 0.0420448612496057 505 29 4 0.137931034482759 0.00792079207920792
GO:CC GO:0005776 autophagosome 0.042496964561083 98 77 3 0.038961038961039 0.0306122448979592
GO:CC GO:0005911 cell-cell junction 0.0438261096451823 494 67 6 0.0895522388059701 0.0121457489878543
GO:CC GO:0043230 extracellular organelle 0.0442000604548997 2263 77 17 0.220779220779221 0.00751215201060539
GO:CC GO:1903561 extracellular vesicle 0.0442000604548997 2261 77 17 0.220779220779221 0.0075187969924812
GO:CC GO:0016020 membrane 0.0470053997394198 9838 39 28 0.717948717948718 0.00284610693230331
GO:MF GO:0004896 cytokine receptor activity 0.0376456254565448 99 86 4 0.0465116279069767 0.0404040404040404
GO:MF GO:0005125 cytokine activity 0.0376456254565448 235 18 3 0.166666666666667 0.0127659574468085
GO:MF GO:0019955 cytokine binding 0.0376456254565448 138 86 5 0.0581395348837209 0.036231884057971
GO:MF GO:0042802 identical protein binding 0.041858623358543 2067 10 5 0.5 0.00241896468311563
GO:MF GO:0140375 immune receptor activity 0.0447918978111284 133 86 4 0.0465116279069767 0.0300751879699248
GO:MF GO:0030246 carbohydrate binding 0.0447918978111284 275 70 5 0.0714285714285714 0.0181818181818182
GO:MF GO:0042803 protein homodimerization activity 0.0472550308033879 676 10 3 0.3 0.00443786982248521
GO:MF GO:0004857 enzyme inhibitor activity 0.0474120124608621 385 56 5 0.0892857142857143 0.012987012987013
REAC REAC:R-HSA-168249 Innate Immune System 0.00147922441676077 1073 71 21 0.295774647887324 0.0195712954333644
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.00227552623844352 474 61 12 0.19672131147541 0.0253164556962025
REAC REAC:R-HSA-168256 Immune System 0.011657248138965 2139 73 29 0.397260273972603 0.0135577372604021
REAC REAC:R-HSA-2172127 DAP12 interactions 0.0223101200639374 33 44 3 0.0681818181818182 0.0909090909090909
WP WP:WP2880 Glucocorticoid Receptor Pathway 0.0177382985193919 71 57 5 0.087719298245614 0.0704225352112676

pM15 transcription factor target enrichment of top program genes

TF enrichment of pM15
TFs corrosponding to activation of pM15. (Left) pearson correlation of TF expression and gene expression program activatity in Myeloid cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.