pEpi15 program activity among Epithelial cells

Activation of pEpi15
pEpi15 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi15 by different cell subtypes
pEpi15 gene program activation among cells of different subtypes (Epithelial cells).

pEpi15 top program genes

Top genes of pEpi15 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi15 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi15
pEpi15 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0043312 neutrophil degranulation 5.44145807511033e-06 482 51 12 0.235294117647059 0.024896265560166
GO:BP GO:0002283 neutrophil activation involved in immune response 5.44145807511033e-06 485 51 12 0.235294117647059 0.0247422680412371
GO:BP GO:0042119 neutrophil activation 5.44145807511033e-06 498 51 12 0.235294117647059 0.0240963855421687
GO:BP GO:0036230 granulocyte activation 5.44145807511033e-06 504 51 12 0.235294117647059 0.0238095238095238
GO:BP GO:0032940 secretion by cell 5.44145807511033e-06 1364 80 23 0.2875 0.0168621700879765
GO:BP GO:0002446 neutrophil mediated immunity 5.44145807511033e-06 497 51 12 0.235294117647059 0.0241448692152917
GO:BP GO:0002275 myeloid cell activation involved in immune response 6.99618906020093e-06 547 51 12 0.235294117647059 0.0219378427787934
GO:BP GO:0002444 myeloid leukocyte mediated immunity 6.99618906020093e-06 551 51 12 0.235294117647059 0.0217785843920145
GO:BP GO:0043299 leukocyte degranulation 6.99618906020093e-06 535 51 12 0.235294117647059 0.0224299065420561
GO:BP GO:0140352 export from cell 6.99618906020093e-06 1418 80 23 0.2875 0.0162200282087447
GO:BP GO:0006887 exocytosis 6.99618906020093e-06 904 94 20 0.212765957446809 0.0221238938053097
GO:BP GO:0006810 transport 1.03686236255934e-05 5224 52 34 0.653846153846154 0.00650842266462481
GO:BP GO:0046903 secretion 1.48227020440935e-05 1501 80 23 0.2875 0.0153231179213857
GO:BP GO:0051234 establishment of localization 1.76478750224244e-05 5372 52 34 0.653846153846154 0.00632911392405063
GO:BP GO:0045055 regulated exocytosis 1.76478750224244e-05 785 94 18 0.191489361702128 0.0229299363057325
GO:BP GO:0002274 myeloid leukocyte activation 3.75005618149842e-05 667 42 11 0.261904761904762 0.0164917541229385
GO:BP GO:0002366 leukocyte activation involved in immune response 7.23872279487938e-05 717 42 11 0.261904761904762 0.0153417015341702
GO:BP GO:0002263 cell activation involved in immune response 7.23872279487938e-05 721 42 11 0.261904761904762 0.0152565880721221
GO:BP GO:0051649 establishment of localization in cell 0.000101218258604773 2813 52 23 0.442307692307692 0.00817632420902951
GO:BP GO:0016192 vesicle-mediated transport 0.000101218258604773 2180 98 30 0.306122448979592 0.0137614678899083
GO:BP GO:0051641 cellular localization 0.000101218258604773 3541 94 39 0.414893617021277 0.0110138378988986
GO:BP GO:0002443 leukocyte mediated immunity 0.0004021796994931 877 42 11 0.261904761904762 0.0125427594070696
GO:BP GO:0090383 phagosome acidification 0.000480372061422489 28 21 3 0.142857142857143 0.107142857142857
GO:BP GO:0051179 localization 0.000546991182177331 6901 52 36 0.692307692307692 0.00521663527025069
GO:BP GO:0033572 transferrin transport 0.000957480593850041 36 21 3 0.142857142857143 0.0833333333333333
GO:BP GO:0000041 transition metal ion transport 0.00131610636202118 129 21 4 0.19047619047619 0.0310077519379845
GO:BP GO:0090382 phagosome maturation 0.00187086555282444 46 21 3 0.142857142857143 0.0652173913043478
GO:BP GO:1902600 proton transmembrane transport 0.00264763007117794 157 21 4 0.19047619047619 0.0254777070063694
GO:BP GO:0051452 intracellular pH reduction 0.00315713239293189 56 21 3 0.142857142857143 0.0535714285714286
GO:BP GO:0045851 pH reduction 0.00357115631530778 59 21 3 0.142857142857143 0.0508474576271186
GO:BP GO:0002252 immune effector process 0.00405743901120681 1309 51 13 0.254901960784314 0.00993124522536287
GO:BP GO:0006826 iron ion transport 0.00832990515414637 80 21 3 0.142857142857143 0.0375
GO:BP GO:0007034 vacuolar transport 0.00975868100144974 154 91 6 0.0659340659340659 0.038961038961039
GO:BP GO:0051453 regulation of intracellular pH 0.0107641242599468 89 21 3 0.142857142857143 0.0337078651685393
GO:BP GO:0045321 leukocyte activation 0.0113865933640674 1332 42 11 0.261904761904762 0.00825825825825826
GO:BP GO:0030641 regulation of cellular pH 0.0113865933640674 95 21 3 0.142857142857143 0.0315789473684211
GO:BP GO:0061912 selective autophagy 0.0113865933640674 63 80 4 0.05 0.0634920634920635
GO:BP GO:0071705 nitrogen compound transport 0.0113865933640674 2322 52 17 0.326923076923077 0.00732127476313523
GO:BP GO:0001775 cell activation 0.0118479718678632 1495 51 13 0.254901960784314 0.00869565217391304
GO:BP GO:0031638 zymogen activation 0.0133319298031197 58 37 3 0.0810810810810811 0.0517241379310345
GO:BP GO:0006885 regulation of pH 0.0133319298031197 103 21 3 0.142857142857143 0.029126213592233
GO:BP GO:0015031 protein transport 0.0138192613989121 1929 52 15 0.288461538461538 0.00777604976671851
GO:BP GO:0015833 peptide transport 0.0171200331423912 1971 52 15 0.288461538461538 0.0076103500761035
GO:BP GO:0030004 cellular monovalent inorganic cation homeostasis 0.0179105811524626 118 21 3 0.142857142857143 0.0254237288135593
GO:BP GO:0042886 amide transport 0.0192337680339256 2007 92 22 0.239130434782609 0.0109616342800199
GO:BP GO:0010631 epithelial cell migration 0.0216533716051955 370 48 6 0.125 0.0162162162162162
GO:BP GO:0045184 establishment of protein localization 0.0217141215029419 2035 52 15 0.288461538461538 0.00737100737100737
GO:BP GO:0090132 epithelium migration 0.0217141215029419 373 48 6 0.125 0.0160857908847185
GO:BP GO:0016236 macroautophagy 0.0219946590411814 312 80 7 0.0875 0.0224358974358974
GO:BP GO:0090130 tissue migration 0.0223146736070785 379 48 6 0.125 0.0158311345646438
GO:BP GO:0071375 cellular response to peptide hormone stimulus 0.0263697782357411 340 21 4 0.19047619047619 0.0117647058823529
GO:BP GO:0008286 insulin receptor signaling pathway 0.0291554709461704 148 21 3 0.142857142857143 0.0202702702702703
GO:BP GO:0006820 anion transport 0.0321637844701561 2889 52 18 0.346153846153846 0.00623052959501558
GO:BP GO:0051047 positive regulation of secretion 0.0343861619689529 314 64 6 0.09375 0.0191082802547771
GO:BP GO:0006955 immune response 0.0343861619689529 2311 14 7 0.5 0.00302899177845089
GO:BP GO:0055067 monovalent inorganic cation homeostasis 0.0355346669219843 165 21 3 0.142857142857143 0.0181818181818182
GO:BP GO:1901653 cellular response to peptide 0.0427676183846759 408 21 4 0.19047619047619 0.00980392156862745
GO:BP GO:0071702 organic substance transport 0.0452034714177633 2766 52 17 0.326923076923077 0.00614605929139552
GO:BP GO:0016485 protein processing 0.0452034714177633 235 37 4 0.108108108108108 0.0170212765957447
GO:BP GO:1903008 organelle disassembly 0.0452034714177633 107 80 4 0.05 0.0373831775700935
GO:BP GO:0010632 regulation of epithelial cell migration 0.0452034714177633 306 48 5 0.104166666666667 0.0163398692810458
GO:CC GO:0031982 vesicle 2.30807809553749e-10 4055 94 52 0.553191489361702 0.0128236744759556
GO:CC GO:0043230 extracellular organelle 1.31972193681612e-07 2263 94 34 0.361702127659574 0.0150243040212108
GO:CC GO:0070062 extracellular exosome 1.31972193681612e-07 2176 58 25 0.431034482758621 0.0114889705882353
GO:CC GO:1903561 extracellular vesicle 2.21162338944173e-07 2261 58 25 0.431034482758621 0.0110570544007077
GO:CC GO:0031410 cytoplasmic vesicle 2.52749646954268e-07 2424 97 35 0.360824742268041 0.0144389438943894
GO:CC GO:0097708 intracellular vesicle 2.52749646954268e-07 2428 97 35 0.360824742268041 0.0144151565074135
GO:CC GO:0099503 secretory vesicle 3.64715691562976e-07 1020 97 22 0.22680412371134 0.0215686274509804
GO:CC GO:0030141 secretory granule 4.20146190911958e-07 851 97 20 0.206185567010309 0.0235017626321974
GO:CC GO:0012505 endomembrane system 2.82451938299527e-05 4640 80 40 0.5 0.00862068965517241
GO:CC GO:0005576 extracellular region 4.2204964030268e-05 4567 88 42 0.477272727272727 0.00919640902123933
GO:CC GO:0005615 extracellular space 5.27872044202983e-05 3594 58 27 0.46551724137931 0.00751252086811352
GO:CC GO:0033176 proton-transporting V-type ATPase complex 0.000103538712330809 27 21 3 0.142857142857143 0.111111111111111
GO:CC GO:0034774 secretory granule lumen 0.000119435354182981 320 94 10 0.106382978723404 0.03125
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.000121969446392971 324 94 10 0.106382978723404 0.0308641975308642
GO:CC GO:0031983 vesicle lumen 0.000121969446392971 326 94 10 0.106382978723404 0.0306748466257669
GO:CC GO:0005773 vacuole 0.000152273939788925 810 80 14 0.175 0.0172839506172839
GO:CC GO:0005774 vacuolar membrane 0.000330117453671486 441 80 10 0.125 0.0226757369614512
GO:CC GO:0070820 tertiary granule 0.000330117453671486 163 37 5 0.135135135135135 0.0306748466257669
GO:CC GO:0030139 endocytic vesicle 0.00034220828995771 306 92 9 0.0978260869565217 0.0294117647058824
GO:CC GO:0070821 tertiary granule membrane 0.00034220828995771 72 14 3 0.214285714285714 0.0416666666666667
GO:CC GO:0016469 proton-transporting two-sector ATPase complex 0.000492162837671904 54 21 3 0.142857142857143 0.0555555555555556
GO:CC GO:0031090 organelle membrane 0.000722764912455041 3612 92 34 0.369565217391304 0.00941306755260244
GO:CC GO:0030667 secretory granule membrane 0.000904953231928663 303 14 4 0.285714285714286 0.0132013201320132
GO:CC GO:0098588 bounding membrane of organelle 0.00108538158808642 2158 92 24 0.260869565217391 0.0111214087117702
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.00141447602544462 779 92 13 0.141304347826087 0.0166880616174583
GO:CC GO:0012506 vesicle membrane 0.00170789083249243 800 92 13 0.141304347826087 0.01625
GO:CC GO:0030666 endocytic vesicle membrane 0.00170789083249243 159 92 6 0.0652173913043478 0.0377358490566038
GO:CC GO:0000323 lytic vacuole 0.0017241822892445 712 77 11 0.142857142857143 0.0154494382022472
GO:CC GO:0005764 lysosome 0.0017241822892445 712 77 11 0.142857142857143 0.0154494382022472
GO:CC GO:0042581 specific granule 0.00235138367981381 158 14 3 0.214285714285714 0.0189873417721519
GO:CC GO:0005768 endosome 0.00319781686404158 987 92 14 0.152173913043478 0.0141843971631206
GO:CC GO:0048471 perinuclear region of cytoplasm 0.00451166036247599 735 98 12 0.122448979591837 0.0163265306122449
GO:CC GO:0030670 phagocytic vesicle membrane 0.00553530912157037 76 92 4 0.0434782608695652 0.0526315789473684
GO:CC GO:0016021 integral component of membrane 0.00837159911890052 5711 112 50 0.446428571428571 0.00875503414463316
GO:CC GO:0098796 membrane protein complex 0.00901079828039444 1322 114 18 0.157894736842105 0.0136157337367625
GO:CC GO:0098852 lytic vacuole membrane 0.00901079828039444 383 77 7 0.0909090909090909 0.0182767624020888
GO:CC GO:0005765 lysosomal membrane 0.00901079828039444 383 77 7 0.0909090909090909 0.0182767624020888
GO:CC GO:0031224 intrinsic component of membrane 0.00975037843834512 5868 113 51 0.451327433628319 0.00869120654396728
GO:CC GO:0035579 specific granule membrane 0.0153467352489031 90 108 4 0.037037037037037 0.0444444444444444
GO:CC GO:1904813 ficolin-1-rich granule lumen 0.0154772554170441 124 37 3 0.0810810810810811 0.0241935483870968
GO:CC GO:0031093 platelet alpha granule lumen 0.0224189793957989 66 80 3 0.0375 0.0454545454545455
GO:CC GO:0043227 membrane-bounded organelle 0.02249830601382 12858 99 80 0.808080808080808 0.00622180743505989
GO:CC GO:0010008 endosome membrane 0.0247329905063298 505 92 8 0.0869565217391304 0.0158415841584158
GO:CC GO:0045335 phagocytic vesicle 0.025967746241959 137 42 3 0.0714285714285714 0.0218978102189781
GO:CC GO:0031970 organelle envelope lumen 0.0306215164269168 97 64 3 0.046875 0.0309278350515464
GO:CC GO:0101002 ficolin-1-rich granule 0.0358402350703976 184 37 3 0.0810810810810811 0.016304347826087
GO:CC GO:0031091 platelet alpha granule 0.0408368614029384 90 80 3 0.0375 0.0333333333333333
GO:CC GO:0005737 cytoplasm 0.0487091191769737 11911 102 76 0.745098039215686 0.00638065653597515
GO:MF GO:0046961 proton-transporting ATPase activity, rotational mechanism 0.000307642555085039 22 74 4 0.0540540540540541 0.181818181818182
GO:MF GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 0.000307642555085039 22 74 4 0.0540540540540541 0.181818181818182
GO:MF GO:0019829 ATPase-coupled cation transmembrane transporter activity 0.00240906361551591 49 21 3 0.142857142857143 0.0612244897959184
GO:MF GO:0042625 ATPase-coupled ion transmembrane transporter activity 0.00240906361551591 51 21 3 0.142857142857143 0.0588235294117647
GO:MF GO:0015078 proton transmembrane transporter activity 0.0261003143257091 125 21 3 0.142857142857143 0.024
GO:MF GO:0016504 peptidase activator activity 0.0261003143257091 42 64 3 0.046875 0.0714285714285714
KEGG KEGG:04966 Collecting duct acid secretion 0.00367732997339061 27 21 3 0.142857142857143 0.111111111111111
KEGG KEGG:05110 Vibrio cholerae infection 0.00736415759832681 50 21 3 0.142857142857143 0.06
KEGG KEGG:04721 Synaptic vesicle cycle 0.00736415759832681 78 34 4 0.117647058823529 0.0512820512820513
KEGG KEGG:00190 Oxidative phosphorylation 0.00736415759832681 133 21 4 0.19047619047619 0.0300751879699248
KEGG KEGG:04145 Phagosome 0.00862148684497736 147 21 4 0.19047619047619 0.0272108843537415
KEGG KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection 0.0106667722510771 70 21 3 0.142857142857143 0.0428571428571429
KEGG KEGG:05323 Rheumatoid arthritis 0.0177803414731889 88 21 3 0.142857142857143 0.0340909090909091
REAC REAC:R-HSA-1222556 ROS and RNS production in phagocytes 0.000176197732409036 36 21 4 0.19047619047619 0.111111111111111
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.000478748094385899 474 37 10 0.27027027027027 0.0210970464135021
REAC REAC:R-HSA-77387 Insulin receptor recycling 0.00153610172683733 26 21 3 0.142857142857143 0.115384615384615
REAC REAC:R-HSA-917977 Transferrin endocytosis and recycling 0.00197904293449505 31 21 3 0.142857142857143 0.0967741935483871
REAC REAC:R-HSA-168249 Innate Immune System 0.00202957973469755 1073 32 12 0.375 0.0111835973904939
REAC REAC:R-HSA-917937 Iron uptake and transport 0.00712026176852914 57 21 3 0.142857142857143 0.0526315789473684
REAC REAC:R-HSA-9639288 Amino acids regulate mTORC1 0.00712026176852914 55 21 3 0.142857142857143 0.0545454545454545
REAC REAC:R-HSA-74752 Signaling by Insulin receptor 0.0109859143777923 69 21 3 0.142857142857143 0.0434782608695652
TF TF:M01588 Factor: GKLF; motif: GCCMCRCCCNNN 6.92604698304811e-05 8944 101 74 0.732673267326733 0.0082737030411449
TF TF:M01588_1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 0.000108860762537438 3962 99 44 0.444444444444444 0.01110550227158
TF TF:M09969 Factor: EKLF; motif: NGGGYGKGGCNNGG 0.000430475129262942 4589 114 51 0.447368421052632 0.0111135323599913
TF TF:M01783_1 Factor: SP2; motif: GGGCGGGAC; match class: 1 0.000430475129262942 4333 113 49 0.433628318584071 0.0113085621970921
TF TF:M03567 Factor: Sp2; motif: NYSGCCCCGCCCCCY 0.000430475129262942 7710 102 65 0.637254901960784 0.00843060959792477
TF TF:M09972_1 Factor: BTEB2; motif: WGGGTGKGGCNGGN; match class: 1 0.000430475129262942 3919 99 42 0.424242424242424 0.0107170196478694
TF TF:M03920_1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 0.000543489427547019 3020 91 33 0.362637362637363 0.0109271523178808
TF TF:M12151 Factor: Sp1; motif: NWRGCCMCGCCCMCN 0.000543489427547019 6821 114 65 0.570175438596491 0.009529394516933
TF TF:M00341 Factor: GABP; motif: VCCGGAAGNGCR 0.000543489427547019 8224 55 41 0.745454545454545 0.00498540856031128
TF TF:M09826_1 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 0.000598286200545603 7508 114 69 0.605263157894737 0.00919019712306873
TF TF:M03807_1 Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 0.000667890753863749 4199 101 43 0.425742574257426 0.0102405334603477
TF TF:M01273 Factor: SP4; motif: SCCCCGCCCCS 0.000784521171110946 3296 47 22 0.468085106382979 0.0066747572815534
TF TF:M09971 Factor: GKLF; motif: WGGGYGKGGC 0.000784521171110946 5546 101 51 0.504950495049505 0.00919581680490444
TF TF:M09971_1 Factor: GKLF; motif: WGGGYGKGGC; match class: 1 0.000795615694384076 1352 104 22 0.211538461538462 0.0162721893491124
TF TF:M03567_1 Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 0.000993941521107127 3614 92 36 0.391304347826087 0.00996126175982291
TF TF:M07409 Factor: BTEB2; motif: GCCCCRCCCH 0.00109591121295897 5198 100 48 0.48 0.00923432089265102
TF TF:M03920 Factor: SP1; motif: RCCMCRCCCMC 0.00133616788001372 7283 101 60 0.594059405940594 0.00823836331182205
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.00158682504561138 9362 114 78 0.684210526315789 0.00833155308694723
TF TF:M09765 Factor: SP1; motif: NRGKGGGCGGGGCN 0.00158682504561138 7469 116 68 0.586206896551724 0.00910429776409158
TF TF:M09826 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC 0.00175513066633301 11467 111 87 0.783783783783784 0.00758698875032703
TF TF:M12188 Factor: KLF17; motif: NGMCMCRCCCTN 0.00230726959498099 3673 7 7 1 0.00190579907432616
TF TF:M10064_1 Factor: slug; motif: RRCAGGTGCN; match class: 1 0.00230726959498099 76 71 5 0.0704225352112676 0.0657894736842105
TF TF:M09973 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN 0.00262707948945742 10853 109 82 0.752293577981651 0.00755551460425689
TF TF:M00008 Factor: Sp1; motif: GGGGCGGGGT 0.00262707948945742 10055 114 81 0.710526315789474 0.00805569368473396
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.00265985349985679 7728 41 30 0.731707317073171 0.00388198757763975
TF TF:M09723 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS 0.00323408147662421 10156 104 75 0.721153846153846 0.00738479716423789
TF TF:M10530_1 Factor: sp4; motif: NNNGCYCCGCCCCCY; match class: 1 0.00323408147662421 3780 91 35 0.384615384615385 0.00925925925925926
TF TF:M04831 Factor: ZEB1; motif: CAGGTGN 0.00323408147662421 8201 108 67 0.62037037037037 0.00816973539812218
TF TF:M09636_1 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 0.00390504674103977 14096 111 98 0.882882882882883 0.00695232690124858
TF TF:M03807 Factor: SP2; motif: GNNGGGGGCGGGGSN 0.00396051489340661 8415 41 31 0.75609756097561 0.00368389780154486
TF TF:M11595 Factor: GCMa; motif: RTGCGGGTN 0.00398961763221992 12117 93 76 0.817204301075269 0.00627217958240489
TF TF:M01284 Factor: Sox-9; motif: RNACAAAGGVN 0.00420731443142076 5964 9 9 1 0.00150905432595573
TF TF:M07040 Factor: GKLF; motif: NNRRGRRNGNSNNN 0.00449675253994047 12705 109 90 0.825688073394495 0.00708382526564345
TF TF:M10067 Factor: Sox-2; motif: NNCCTTTGTNYYN 0.00487306521158735 6131 9 9 1 0.00146794976349698
TF TF:M10071 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG 0.00487306521158735 8495 99 63 0.636363636363636 0.007416127133608
TF TF:M10072_1 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 0.00487306521158735 6225 99 51 0.515151515151515 0.00819277108433735
TF TF:M08441_1 Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 0.00487306521158735 12761 69 60 0.869565217391304 0.00470182587571507
TF TF:M07277 Factor: BTEB2; motif: RGGGNGKGGN 0.00487306521158735 8492 114 71 0.62280701754386 0.00836081017428168
TF TF:M10069_1 Factor: Sox-4; motif: NYCTTTGTYYYN; match class: 1 0.00487402945976351 1742 6 5 0.833333333333333 0.00287026406429392
TF TF:M09969_1 Factor: EKLF; motif: NGGGYGKGGCNNGG; match class: 1 0.00499395452839665 1489 97 20 0.206185567010309 0.0134318334452653
TF TF:M07615 Factor: Sp3; motif: GGGGCGGGGSNN 0.0052183654159342 6807 99 54 0.545454545454545 0.00793301013662406
TF TF:M10435 Factor: Sp2; motif: GGGGCGGGG 0.00571689355593936 7696 102 60 0.588235294117647 0.0077962577962578
TF TF:M12136 Factor: mbnl2; motif: NYGCYTYGCYTN 0.00571689355593936 5391 102 47 0.46078431372549 0.00871823409386014
TF TF:M07063 Factor: Sp1; motif: GGGGCGGGGC 0.00571689355593936 7696 102 60 0.588235294117647 0.0077962577962578
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.0057961915783545 13611 111 95 0.855855855855856 0.0069796488134597
TF TF:M09967 Factor: AP-2rep; motif: NGGGGCGGGGC 0.0057961915783545 4023 47 22 0.468085106382979 0.00546855580412627
TF TF:M08878_1 Factor: EGR; motif: CGCCCCCGCNN; match class: 1 0.0057961915783545 3224 114 36 0.315789473684211 0.011166253101737
TF TF:M08453 Factor: ERF:SREBP-2; motif: NSCGGAARTCACGTGAT 0.0057961915783545 10112 15 15 1 0.00148338607594937
TF TF:M00932_1 Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 0.0057961915783545 6047 113 55 0.486725663716814 0.00909541921614023
TF TF:M12173 Factor: GKLF; motif: NNCCMCRCCCN 0.00584900001644562 10023 114 79 0.692982456140351 0.00788187169510127
TF TF:M00931_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.00599149366443493 5905 113 54 0.47787610619469 0.00914479254868755
TF TF:M10072 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR 0.00647895368881026 10494 99 72 0.727272727272727 0.00686106346483705
TF TF:M12173_1 Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 0.00663409847242901 4965 114 48 0.421052631578947 0.00966767371601208
TF TF:M10071_1 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 0.00682159662975589 4623 93 39 0.419354838709677 0.00843608046722907
TF TF:M07040_1 Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1 0.00697125491140838 8156 114 68 0.596491228070175 0.00833742030407062
TF TF:M10477_1 Factor: ZNF436; motif: TCCTCCAGGAAGCCY; match class: 1 0.00763740425418692 8681 59 41 0.694915254237288 0.00472295818454095
TF TF:M09765_1 Factor: SP1; motif: NRGKGGGCGGGGCN; match class: 1 0.00831928955483403 3318 97 32 0.329896907216495 0.00964436407474382
TF TF:M12259_1 Factor: slug; motif: NRCAGGTGCR; match class: 1 0.00836949876290501 105 82 5 0.0609756097560976 0.0476190476190476
TF TF:M09972 Factor: BTEB2; motif: WGGGTGKGGCNGGN 0.00836949876290501 9217 100 66 0.66 0.00716068134967994
TF TF:M00932 Factor: Sp1; motif: NNGGGGCGGGGNN 0.0087823180330422 10419 102 73 0.715686274509804 0.00700643055955466
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.00880036580187527 6334 113 56 0.495575221238938 0.00884117461319861
TF TF:M12256_1 Factor: SNA; motif: NRCAGGTGNN; match class: 1 0.00997505877383745 206 71 6 0.0845070422535211 0.029126213592233
TF TF:M09671 Factor: VDR; motif: RRGGTCANNGRGKTCA 0.00997505877383745 8106 88 54 0.613636363636364 0.00666173205033309
TF TF:M01783 Factor: SP2; motif: GGGCGGGAC 0.0105425048584043 9148 114 73 0.640350877192982 0.0079798863139484
TF TF:M00008_1 Factor: Sp1; motif: GGGGCGGGGT; match class: 1 0.0105425048584043 4937 111 46 0.414414414414414 0.0093173992303018
TF TF:M00196_1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 0.0107807110883149 5919 113 53 0.469026548672566 0.00895421523906065
TF TF:M00933 Factor: Sp1; motif: CCCCGCCCCN 0.0110812247505294 9715 33 27 0.818181818181818 0.00277920741121976
TF TF:M12152 Factor: Sp1; motif: NWRGCCACGCCCMCN 0.0119178891828086 7341 116 63 0.543103448275862 0.00858193706579485
TF TF:M01104 Factor: MOVO-B; motif: GNGGGGG 0.0119178891828086 10261 114 79 0.692982456140351 0.00769905467303382
TF TF:M07354_1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 0.0137186328726492 3561 106 35 0.330188679245283 0.009828699803426
TF TF:M04918 Factor: Egr-1; motif: ACCGCCC 0.0138385184306924 5608 95 44 0.463157894736842 0.00784593437945792
TF TF:M04490_1 Factor: RXRA; motif: RRGGTCATGACCYY; match class: 1 0.0138385184306924 3535 14 9 0.642857142857143 0.00254596888260255
TF TF:M12261_1 Factor: slug; motif: NRCAGGTGCR; match class: 1 0.0138385184306924 195 82 6 0.0731707317073171 0.0307692307692308
TF TF:M12257_1 Factor: SNA; motif: NRCAGGTGCR; match class: 1 0.0138385184306924 195 82 6 0.0731707317073171 0.0307692307692308
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.0138385184306924 10281 38 31 0.815789473684211 0.00301527088804591
TF TF:M00184 Factor: MyoD; motif: NNCACCTGNY 0.0148056602911065 1030 40 9 0.225 0.0087378640776699
TF TF:M00803 Factor: E2F; motif: GGCGSG 0.0148736357812533 13190 93 78 0.838709677419355 0.00591357088703563
TF TF:M08623_1 Factor: rfx3:SRF; motif: TRGCAACNNNNNCCNWATANGGN; match class: 1 0.0150350262812823 8140 16 14 0.875 0.00171990171990172
TF TF:M09898_1 Factor: Egr-2; motif: GNGRRNGWGKGGGNGGRG; match class: 1 0.0150350262812823 2541 108 28 0.259259259259259 0.0110192837465565
TF TF:M10068 Factor: Sox-3; motif: NCCTTTGTNYN 0.0150350262812823 1650 8 5 0.625 0.00303030303030303
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.0153867830666982 10640 102 73 0.715686274509804 0.0068609022556391
TF TF:M00450_1 Factor: Zic3; motif: NGGGKGGTC; match class: 1 0.0153867830666982 7927 116 66 0.568965517241379 0.00832597451747193
TF TF:M00746 Factor: Elf-1; motif: RNWMBAGGAART 0.0154638265157161 3365 92 30 0.326086956521739 0.00891530460624071
TF TF:M01073 Factor: HIC1; motif: NNNGGKTGCCCSNNNNNN 0.0158543794105935 4088 29 15 0.517241379310345 0.0036692759295499
TF TF:M00986 Factor: Churchill; motif: CGGGNN 0.0158543794105935 14197 111 96 0.864864864864865 0.00676199197013454
TF TF:M10069 Factor: Sox-4; motif: NYCTTTGTYYYN 0.0158543794105935 7334 26 19 0.730769230769231 0.00259067357512953
TF TF:M07409_1 Factor: BTEB2; motif: GCCCCRCCCH; match class: 1 0.0158543794105935 1829 91 20 0.21978021978022 0.0109349371241115
TF TF:M08220_1 Factor: Elk-1:HOXA3; motif: ACCGGWAATKRNNTNWCNNATTAN; match class: 1 0.0166098233997597 5350 38 21 0.552631578947368 0.00392523364485981
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.0170544017116055 10233 65 48 0.738461538461539 0.00469070653767224
TF TF:M12186_1 Factor: BTEB4; motif: NCCACGCCCM; match class: 1 0.0170544017116055 3958 91 33 0.362637362637363 0.00833754421424962
TF TF:M07277_1 Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 0.0178384408291283 4149 98 36 0.36734693877551 0.00867678958785249
TF TF:M11300 Factor: B-ATF; motif: NNATGACACN 0.0188491268003266 8842 75 49 0.653333333333333 0.00554173263967428
TF TF:M11490_1 Factor: LBP-1; motif: NRCCGGTNNNNACCGGYN; match class: 1 0.0194237982894701 5988 22 15 0.681818181818182 0.00250501002004008
TF TF:M09636 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG 0.0194486952226448 16244 114 107 0.93859649122807 0.00658704752524009
TF TF:M12262_1 Factor: slug; motif: RRCAGGTGCA; match class: 1 0.0199067345238892 141 82 5 0.0609756097560976 0.0354609929078014
TF TF:M09970_1 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 0.0199067345238892 3783 92 32 0.347826086956522 0.0084588950568332
TF TF:M11155_1 Factor: ITF-2; motif: NCACCTGN; match class: 1 0.0202295100163789 312 82 7 0.0853658536585366 0.0224358974358974
TF TF:M03565_1 Factor: slug; motif: KCACCTGN; match class: 1 0.0202295100163789 312 82 7 0.0853658536585366 0.0224358974358974
TF TF:M09729 Factor: LUMAN; motif: CYCAGCYYCY 0.0202295100163789 10686 109 77 0.706422018348624 0.00720568968744151
TF TF:M12262 Factor: slug; motif: RRCAGGTGCA 0.0232182416875591 2088 90 21 0.233333333333333 0.0100574712643678
TF TF:M01660 Factor: GABP-alpha; motif: CTTCCK 0.0232182416875591 11116 89 66 0.741573033707865 0.00593738754947823
TF TF:M08877_1 Factor: EGR3; motif: NCMCRCCCACTNMN; match class: 1 0.0232182416875591 1397 96 17 0.177083333333333 0.0121689334287759
TF TF:M12186 Factor: BTEB4; motif: NCCACGCCCM 0.0232182416875591 9135 99 63 0.636363636363636 0.00689655172413793
TF TF:M04143 Factor: TEAD3; motif: RCATTCCNNRCATWCCN 0.0247511867450924 78 88 4 0.0454545454545455 0.0512820512820513
TF TF:M09723_1 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 0.0252611228113281 6113 99 47 0.474747474747475 0.00768853263536725
TF TF:M12258_1 Factor: SNA; motif: NRCAGGTGCA; match class: 1 0.0253385259409106 234 82 6 0.0731707317073171 0.0256410256410256
TF TF:M09734 Factor: ZNF692; motif: SYNGGSCCCASCCNC 0.0253385259409106 11678 114 85 0.745614035087719 0.00727864360335674
TF TF:M01873_1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 0.0285446007918769 2672 88 24 0.272727272727273 0.00898203592814371
TF TF:M09734_1 Factor: ZNF692; motif: SYNGGSCCCASCCNC; match class: 1 0.0295265235234551 6255 113 53 0.469026548672566 0.00847322142286171
TF TF:M00646_1 Factor: LF-A1; motif: GGGSTCWR; match class: 1 0.0300018498503154 6320 16 12 0.75 0.00189873417721519
TF TF:M11396 Factor: Erg; motif: NACCGGAARTN 0.0314073139736326 10765 81 59 0.728395061728395 0.00548072457036693
TF TF:M00982_1 Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1 0.0314242416869006 3518 114 35 0.307017543859649 0.0099488345650938
TF TF:M11435 Factor: Elk-1; motif: NNCCGGAAGTN 0.0320861015230611 11728 89 68 0.764044943820225 0.00579809004092769
TF TF:M09884 Factor: CLOCK; motif: CNGNCACGTGNNNM 0.0321089476886708 8420 15 13 0.866666666666667 0.00154394299287411
TF TF:M03977 Factor: ETS1; motif: ACCGGAARYN 0.0321089476886708 10512 94 66 0.702127659574468 0.00627853881278539
TF TF:M05327 Factor: WT1; motif: NGCGGGGGGGTSMMCYN 0.0321089476886708 5509 110 47 0.427272727272727 0.00853149391904157
TF TF:M09904 Factor: Elk-1; motif: RCCGGAAGTGN 0.0321089476886708 8164 82 49 0.597560975609756 0.00600195982361587
TF TF:M04811_1 Factor: RelA-p65; motif: BCWGGGRANNK; match class: 1 0.0322356101767536 1834 98 20 0.204081632653061 0.0109051254089422
TF TF:M10530 Factor: sp4; motif: NNNGCYCCGCCCCCY 0.0322356101767536 8227 62 39 0.629032258064516 0.00474048863498238
TF TF:M11451_1 Factor: Elf-1; motif: NANCCGGAAGTN; match class: 1 0.033548541487784 2112 80 19 0.2375 0.00899621212121212
TF TF:M08759 Factor: c-Ets-2; motif: NCCGGAAGTG 0.0347424703492786 8319 81 49 0.604938271604938 0.00589013102536363
TF TF:M10014 Factor: FXR; motif: NRGGKCANTGRCCNNNNGG 0.034836423054246 5652 22 14 0.636363636363636 0.00247699929228592
TF TF:M08225_1 Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 0.0365650923408538 7993 8 8 1 0.00100087576629551
TF TF:M11399 Factor: Fli-1; motif: NACCGGAWWTCCGGTY 0.0365650923408538 12977 114 91 0.798245614035088 0.00701240656546197
TF TF:M07435 Factor: TWIST; motif: MNACACNTGGN 0.037140648911911 1488 16 6 0.375 0.00403225806451613
TF TF:M01652 Factor: p53; motif: RGRCWWGYCYNGRCWWGYYY 0.037140648911911 8083 114 64 0.56140350877193 0.00791785228256835
TF TF:M12351_1 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 0.037140648911911 8180 55 35 0.636363636363636 0.00427872860635697
TF TF:M08905_1 Factor: TIEG1; motif: GGSGGKGNNN; match class: 1 0.0384382423022917 1017 59 10 0.169491525423729 0.00983284169124877
TF TF:M00072 Factor: CP2; motif: GCHCDAMCCAG 0.0384382423022917 8876 111 67 0.603603603603604 0.00754844524560613
TF TF:M12158_1 Factor: KLF15; motif: NCCMCGCCCMCN; match class: 1 0.0384382423022917 6004 95 44 0.463157894736842 0.00732844770153231
TF TF:M11400 Factor: Fli-1; motif: NACCGGAARTN 0.0389122719877553 9946 94 63 0.670212765957447 0.00633420470540921
TF TF:M10121 Factor: ZFX; motif: SNAGGCCNCR 0.0389122719877553 3997 92 32 0.347826086956522 0.00800600450337753
TF TF:M02102 Factor: NRF-1; motif: YGCGCMTGCGC 0.0393707819024384 2020 54 14 0.259259259259259 0.00693069306930693
TF TF:M12156 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN 0.0394895990756722 4320 114 40 0.350877192982456 0.00925925925925926
TF TF:M05775 Factor: ZXDL; motif: NGGGGWS 0.0404956644300193 6964 114 57 0.5 0.0081849511774842
TF TF:M12153 Factor: Sp3; motif: NGCCACGCCCMCN 0.0408387146334625 6205 116 53 0.456896551724138 0.00854149879129734
TF TF:M09898 Factor: Egr-2; motif: GNGRRNGWGKGGGNGGRG 0.0408387146334625 6484 99 48 0.484848484848485 0.00740283775447255
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 0.0438377006087302 13929 111 93 0.837837837837838 0.00667671763945725
TF TF:M02111_1 Factor: NR1B2; motif: NTGACCY; match class: 1 0.0438377006087302 3323 35 14 0.4 0.00421306048751129
TF TF:M10018 Factor: NRF-1; motif: CNSTGCGCATGCGCNNS 0.0438377006087302 1816 74 16 0.216216216216216 0.00881057268722467
TF TF:M01660_1 Factor: GABP-alpha; motif: CTTCCK; match class: 1 0.0438377006087302 5133 83 35 0.421686746987952 0.00681862458601208
TF TF:M00051_1 Factor: NF-kappaB; motif: GGGGATYCCC; match class: 1 0.0444350820984054 2797 114 29 0.254385964912281 0.0103682516982481
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.0444350820984054 6260 113 52 0.460176991150442 0.00830670926517572
TF TF:M11732 Factor: PXR; motif: NYGAACYNNNYGMMCTN 0.0444350820984054 2795 10 6 0.6 0.00214669051878354
TF TF:M04129 Factor: TBX20; motif: WAGGTGTGAAR 0.0457146154941632 133 30 3 0.1 0.0225563909774436
TF TF:M00652 Factor: NRF-1; motif: CGCATGCGCR 0.0459827716648988 1376 54 11 0.203703703703704 0.00799418604651163
TF TF:M09910_1 Factor: ER-beta; motif: RGGTCASCNTGMCCY; match class: 1 0.0459827716648988 4079 114 38 0.333333333333333 0.00931600882569257
TF TF:M03967 Factor: ELF3; motif: WACCCGGAAGTAN 0.0460940665936448 7610 39 25 0.641025641025641 0.00328515111695138
TF TF:M00051 Factor: NF-kappaB; motif: GGGGATYCCC 0.0461205628961921 6413 116 54 0.46551724137931 0.00842039607048183
TF TF:M05432 Factor: ZSCAN18; motif: TRRCGRCGNMCC 0.0466383016816485 4117 59 23 0.389830508474576 0.00558659217877095
TF TF:M11490 Factor: LBP-1; motif: NRCCGGTNNNNACCGGYN 0.0487453871750833 6748 22 15 0.681818181818182 0.00222288085358625
TF TF:M09897 Factor: Egr-1; motif: NNNNGCGKGGGYGGNRN 0.0487453871750833 4244 114 39 0.342105263157895 0.00918944392082941
TF TF:M01837_1 Factor: FKLF; motif: BGGGNGGVMD; match class: 1 0.0489665321495252 1413 96 16 0.166666666666667 0.0113234253361642
TF TF:M00412_1 Factor: AREB6; motif: NNYNYACCTGWVT; match class: 1 0.0489665321495252 656 25 5 0.2 0.00762195121951219
TF TF:M01196_1 Factor: CTF1; motif: TGGCASCNNGCCAA; match class: 1 0.0489665321495252 1572 63 13 0.206349206349206 0.00826972010178117
TF TF:M00652_1 Factor: NRF-1; motif: CGCATGCGCR; match class: 1 0.0489665321495252 317 74 6 0.0810810810810811 0.0189274447949527
TF TF:M11028_1 Factor: Six-1; motif: NCGTATCRNN; match class: 1 0.0489665321495252 161 98 5 0.0510204081632653 0.031055900621118
TF TF:M12000_1 Factor: AML3; motif: NNAACCGCAAWAACCGCAAN; match class: 1 0.0489665321495252 1586 94 17 0.180851063829787 0.010718789407314
TF TF:M04106 Factor: RUNX2; motif: NRACCGCAAACCGCAN 0.0489665321495252 13833 112 93 0.830357142857143 0.00672305356755584
TF TF:M10529 Factor: Sp1; motif: RGGGMGGRGSNGGGG 0.0489665321495252 6891 114 56 0.491228070175439 0.00812654186620229
TF TF:M01034_1 Factor: Ebox; motif: NCACSTGNCN; match class: 1 0.0497080346406968 879 38 7 0.184210526315789 0.00796359499431172
TF TF:M07226 Factor: SP1; motif: NCCCCKCCCCC 0.0497191860434004 8292 99 57 0.575757575757576 0.00687409551374819
WP WP:WP4917 Proximal tubule transport 0.0389560771293388 58 21 3 0.142857142857143 0.0517241379310345

pEpi15 transcription factor target enrichment of top program genes

TF enrichment of pEpi15
Possible regulators of activation of pEpi15 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.