pEpiTp32 program activity among Epithelial cells

Activation of pEpiTp32
pEpiTp32 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp32 by different cell subtypes
pEpiTp32 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp32 top program genes

Top genes of pEpiTp32 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp32 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp32
pEpiTp32 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0015990 electron transport coupled proton transport 2.11881563794883e-05 5 22 3 0.136363636363636 0.6
GO:BP GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient 2.11881563794883e-05 5 22 3 0.136363636363636 0.6
GO:BP GO:0034379 very-low-density lipoprotein particle assembly 0.00141582061494065 13 33 3 0.0909090909090909 0.230769230769231
GO:BP GO:0001666 response to hypoxia 0.00182855155337784 367 59 9 0.152542372881356 0.0245231607629428
GO:BP GO:0036293 response to decreased oxygen levels 0.00202827835096356 382 59 9 0.152542372881356 0.0235602094240838
GO:BP GO:0070482 response to oxygen levels 0.00288152732223252 408 59 9 0.152542372881356 0.0220588235294118
GO:BP GO:0034377 plasma lipoprotein particle assembly 0.00725339804963424 31 33 3 0.0909090909090909 0.0967741935483871
GO:BP GO:0015711 organic anion transport 0.00725339804963424 386 91 10 0.10989010989011 0.0259067357512953
GO:BP GO:0065005 protein-lipid complex assembly 0.00945817471764401 35 33 3 0.0909090909090909 0.0857142857142857
GO:BP GO:0030155 regulation of cell adhesion 0.0111760190689011 748 86 13 0.151162790697674 0.017379679144385
GO:BP GO:0098660 inorganic ion transmembrane transport 0.0126761084649213 883 24 7 0.291666666666667 0.00792751981879955
GO:BP GO:0071827 plasma lipoprotein particle organization 0.0126761084649213 52 33 3 0.0909090909090909 0.0576923076923077
GO:BP GO:0034446 substrate adhesion-dependent cell spreading 0.0126761084649213 109 42 4 0.0952380952380952 0.036697247706422
GO:BP GO:0016101 diterpenoid metabolic process 0.0126761084649213 113 40 4 0.1 0.0353982300884956
GO:BP GO:0045454 cell redox homeostasis 0.0126761084649213 58 72 4 0.0555555555555556 0.0689655172413793
GO:BP GO:0002443 leukocyte mediated immunity 0.0126761084649213 877 89 14 0.157303370786517 0.015963511972634
GO:BP GO:0046942 carboxylic acid transport 0.0126761084649213 294 91 8 0.0879120879120879 0.0272108843537415
GO:BP GO:0002544 chronic inflammatory response 0.0126761084649213 19 77 3 0.038961038961039 0.157894736842105
GO:BP GO:0044281 small molecule metabolic process 0.0126761084649213 1921 47 15 0.319148936170213 0.00780843310775638
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.0126761084649213 1042 35 9 0.257142857142857 0.00863723608445298
GO:BP GO:0022900 electron transport chain 0.0126761084649213 180 24 4 0.166666666666667 0.0222222222222222
GO:BP GO:0001523 retinoid metabolic process 0.0126761084649213 107 40 4 0.1 0.0373831775700935
GO:BP GO:0043312 neutrophil degranulation 0.0127021810701045 482 89 10 0.112359550561798 0.020746887966805
GO:BP GO:0002283 neutrophil activation involved in immune response 0.0128848650972739 485 89 10 0.112359550561798 0.0206185567010309
GO:BP GO:0071825 protein-lipid complex subunit organization 0.0134578667322113 56 33 3 0.0909090909090909 0.0535714285714286
GO:BP GO:0006721 terpenoid metabolic process 0.0139314270631397 123 40 4 0.1 0.032520325203252
GO:BP GO:0042119 neutrophil activation 0.0139788899494254 498 89 10 0.112359550561798 0.0200803212851406
GO:BP GO:0002446 neutrophil mediated immunity 0.0139788899494254 497 89 10 0.112359550561798 0.0201207243460765
GO:BP GO:1900024 regulation of substrate adhesion-dependent cell spreading 0.0144450222219611 58 35 3 0.0857142857142857 0.0517241379310345
GO:BP GO:0006950 response to stress 0.0144450222219611 4170 64 28 0.4375 0.00671462829736211
GO:BP GO:0007586 digestion 0.0144450222219611 141 15 3 0.2 0.0212765957446809
GO:BP GO:0036230 granulocyte activation 0.0144450222219611 504 89 10 0.112359550561798 0.0198412698412698
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 0.0158280033209595 99 22 3 0.136363636363636 0.0303030303030303
GO:BP GO:0042773 ATP synthesis coupled electron transport 0.0158970861148534 100 22 3 0.136363636363636 0.03
GO:BP GO:1902600 proton transmembrane transport 0.0171588773236988 157 36 4 0.111111111111111 0.0254777070063694
GO:BP GO:0006720 isoprenoid metabolic process 0.0182125822657876 144 40 4 0.1 0.0277777777777778
GO:BP GO:0034220 ion transmembrane transport 0.0182423041039688 1397 24 8 0.333333333333333 0.00572655690765927
GO:BP GO:0043299 leukocyte degranulation 0.0182423041039688 535 89 10 0.112359550561798 0.0186915887850467
GO:BP GO:0006575 cellular modified amino acid metabolic process 0.0188591906737657 199 117 7 0.0598290598290598 0.0351758793969849
GO:BP GO:0022904 respiratory electron transport chain 0.0196811181730168 117 22 3 0.136363636363636 0.0256410256410256
GO:BP GO:0030277 maintenance of gastrointestinal epithelium 0.0196811181730168 21 122 3 0.0245901639344262 0.142857142857143
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0196811181730168 551 89 10 0.112359550561798 0.0181488203266788
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0196811181730168 547 89 10 0.112359550561798 0.0182815356489945
GO:BP GO:0009653 anatomical structure morphogenesis 0.0202385596049799 2797 43 16 0.372093023255814 0.00572041473006793
GO:BP GO:0002274 myeloid leukocyte activation 0.0203317397263558 667 89 11 0.123595505617978 0.0164917541229385
GO:BP GO:0006952 defense response 0.0211826907482876 1818 52 14 0.269230769230769 0.0077007700770077
GO:BP GO:0098662 inorganic cation transmembrane transport 0.0218819608031661 794 24 6 0.25 0.00755667506297229
GO:BP GO:0007155 cell adhesion 0.0241290352583821 1492 86 17 0.197674418604651 0.0113941018766756
GO:BP GO:0022610 biological adhesion 0.0245254464688442 1499 86 17 0.197674418604651 0.0113408939292862
GO:BP GO:0042445 hormone metabolic process 0.0245254464688442 228 31 4 0.129032258064516 0.0175438596491228
GO:BP GO:0044282 small molecule catabolic process 0.0254212542284164 439 44 6 0.136363636363636 0.0136674259681093
GO:BP GO:0055114 obsolete oxidation-reduction process 0.0265707676717252 745 48 8 0.166666666666667 0.010738255033557
GO:BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 0.0274730264809895 167 77 5 0.0649350649350649 0.029940119760479
GO:BP GO:0051179 localization 0.0274730264809895 6901 59 35 0.593220338983051 0.00507172873496595
GO:BP GO:0006954 inflammatory response 0.0276888989185132 794 81 11 0.135802469135802 0.0138539042821159
GO:BP GO:0022604 regulation of cell morphogenesis 0.0276888989185132 309 43 5 0.116279069767442 0.0161812297734628
GO:BP GO:0006119 oxidative phosphorylation 0.0276888989185132 151 22 3 0.136363636363636 0.0198675496688742
GO:BP GO:0055085 transmembrane transport 0.028640926270172 1635 24 8 0.333333333333333 0.00489296636085627
GO:BP GO:0001906 cell killing 0.028640926270172 175 44 4 0.0909090909090909 0.0228571428571429
GO:BP GO:0010769 regulation of cell morphogenesis involved in differentiation 0.028640926270172 97 35 3 0.0857142857142857 0.0309278350515464
GO:BP GO:0002819 regulation of adaptive immune response 0.0293333063370238 167 81 5 0.0617283950617284 0.029940119760479
GO:BP GO:1901136 carbohydrate derivative catabolic process 0.0293333063370238 196 40 4 0.1 0.0204081632653061
GO:BP GO:0032940 secretion by cell 0.0293333063370238 1364 89 16 0.179775280898876 0.0117302052785924
GO:BP GO:0002526 acute inflammatory response 0.0296770081129199 114 122 5 0.040983606557377 0.043859649122807
GO:BP GO:0010669 epithelial structure maintenance 0.0296770081129199 29 122 3 0.0245901639344262 0.103448275862069
GO:BP GO:0045055 regulated exocytosis 0.0296770081129199 785 125 14 0.112 0.0178343949044586
GO:BP GO:0006629 lipid metabolic process 0.0296770081129199 1457 40 10 0.25 0.00686341798215511
GO:BP GO:0097006 regulation of plasma lipoprotein particle levels 0.0296770081129199 107 33 3 0.0909090909090909 0.0280373831775701
GO:BP GO:0098655 cation transmembrane transport 0.0296770081129199 914 24 6 0.25 0.00656455142231947
GO:BP GO:0045333 cellular respiration 0.03222028311537 192 44 4 0.0909090909090909 0.0208333333333333
GO:BP GO:0051234 establishment of localization 0.0341303539571415 5372 54 27 0.5 0.00502606105733433
GO:BP GO:0007005 mitochondrion organization 0.0341303539571415 561 27 5 0.185185185185185 0.0089126559714795
GO:BP GO:0140352 export from cell 0.0349048238589762 1418 89 16 0.179775280898876 0.0112834978843441
GO:BP GO:0035725 sodium ion transmembrane transport 0.035560377468726 171 24 3 0.125 0.0175438596491228
GO:BP GO:0006887 exocytosis 0.035560377468726 904 125 15 0.12 0.0165929203539823
GO:BP GO:0002252 immune effector process 0.0404332805376753 1309 89 15 0.168539325842697 0.0114591291061879
GO:BP GO:0000904 cell morphogenesis involved in differentiation 0.0409901347190993 749 43 7 0.162790697674419 0.00934579439252336
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.0409901347190993 1202 43 9 0.209302325581395 0.00748752079866889
GO:BP GO:0010817 regulation of hormone levels 0.0409901347190993 536 44 6 0.136363636363636 0.0111940298507463
GO:BP GO:0034754 cellular hormone metabolic process 0.0409901347190993 140 31 3 0.0967741935483871 0.0214285714285714
GO:BP GO:0006810 transport 0.0429156396831314 5224 54 26 0.481481481481481 0.00497702909647779
GO:BP GO:0010718 positive regulation of epithelial to mesenchymal transition 0.0429156396831314 51 89 3 0.0337078651685393 0.0588235294117647
GO:BP GO:0006812 cation transport 0.0429156396831314 1197 36 8 0.222222222222222 0.00668337510442774
GO:BP GO:0045087 innate immune response 0.0429156396831314 998 52 9 0.173076923076923 0.00901803607214429
GO:BP GO:0002703 regulation of leukocyte mediated immunity 0.0433717564936102 205 81 5 0.0617283950617284 0.024390243902439
GO:BP GO:0001909 leukocyte mediated cytotoxicity 0.0433717564936102 107 44 3 0.0681818181818182 0.0280373831775701
GO:BP GO:0001775 cell activation 0.0433717564936102 1495 105 18 0.171428571428571 0.0120401337792642
GO:BP GO:0032496 response to lipopolysaccharide 0.0448435372027145 338 98 7 0.0714285714285714 0.0207100591715976
GO:BP GO:0046903 secretion 0.0455526875091327 1501 89 16 0.179775280898876 0.0106595602931379
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0466777220567808 717 89 10 0.112359550561798 0.0139470013947001
GO:BP GO:0015718 monocarboxylic acid transport 0.0466777220567808 189 91 5 0.0549450549450549 0.0264550264550265
GO:BP GO:1903428 positive regulation of reactive oxygen species biosynthetic process 0.0466777220567808 62 81 3 0.037037037037037 0.0483870967741935
GO:BP GO:0002263 cell activation involved in immune response 0.0466777220567808 721 89 10 0.112359550561798 0.013869625520111
GO:BP GO:0015849 organic acid transport 0.0466777220567808 331 103 7 0.0679611650485437 0.0211480362537764
GO:BP GO:0002699 positive regulation of immune effector process 0.0466777220567808 215 81 5 0.0617283950617284 0.0232558139534884
GO:BP GO:0007162 negative regulation of cell adhesion 0.0466777220567808 304 84 6 0.0714285714285714 0.0197368421052632
GO:BP GO:0046718 viral entry into host cell 0.0471049953681894 141 126 5 0.0396825396825397 0.0354609929078014
GO:BP GO:1901135 carbohydrate derivative metabolic process 0.0472530550337182 1145 40 8 0.2 0.00698689956331878
GO:BP GO:1903409 reactive oxygen species biosynthetic process 0.0472576963562857 135 81 4 0.0493827160493827 0.0296296296296296
GO:BP GO:0098656 anion transmembrane transport 0.0484152255839957 550 21 4 0.19047619047619 0.00727272727272727
GO:BP GO:0002237 response to molecule of bacterial origin 0.0496215511397822 361 98 7 0.0714285714285714 0.0193905817174515
GO:CC GO:0005773 vacuole 0.00152583460020842 810 89 15 0.168539325842697 0.0185185185185185
GO:CC GO:1990204 oxidoreductase complex 0.00382371209612415 113 29 4 0.137931034482759 0.0353982300884956
GO:CC GO:0000323 lytic vacuole 0.00396282192935563 712 89 12 0.134831460674157 0.0168539325842697
GO:CC GO:0005746 mitochondrial respirasome 0.00396282192935563 89 22 3 0.136363636363636 0.0337078651685393
GO:CC GO:0005764 lysosome 0.00396282192935563 712 89 12 0.134831460674157 0.0168539325842697
GO:CC GO:0031982 vesicle 0.00396282192935563 4055 47 22 0.468085106382979 0.00542540073982737
GO:CC GO:0070062 extracellular exosome 0.00396282192935563 2176 45 15 0.333333333333333 0.00689338235294118
GO:CC GO:1903561 extracellular vesicle 0.00396282192935563 2261 45 15 0.333333333333333 0.00663423264042459
GO:CC GO:0005615 extracellular space 0.00396282192935563 3594 45 20 0.444444444444444 0.00556483027267668
GO:CC GO:0098803 respiratory chain complex 0.00396282192935563 86 22 3 0.136363636363636 0.0348837209302326
GO:CC GO:0043230 extracellular organelle 0.00396282192935563 2263 45 15 0.333333333333333 0.0066283694211224
GO:CC GO:0005576 extracellular region 0.00465487478698721 4567 47 23 0.48936170212766 0.0050361287497263
GO:CC GO:0070469 respirasome 0.00516716394142417 103 22 3 0.136363636363636 0.029126213592233
GO:CC GO:0005775 vacuolar lumen 0.0104382384033086 174 40 4 0.1 0.0229885057471264
GO:CC GO:0098800 inner mitochondrial membrane protein complex 0.0123396421467632 146 22 3 0.136363636363636 0.0205479452054795
GO:CC GO:0031224 intrinsic component of membrane 0.0123396421467632 5868 75 37 0.493333333333333 0.00630538513974097
GO:CC GO:0071944 cell periphery 0.0139137673794254 6169 107 51 0.476635514018692 0.00826714216242503
GO:CC GO:0012505 endomembrane system 0.0156003984373851 4640 42 20 0.476190476190476 0.00431034482758621
GO:CC GO:0045177 apical part of cell 0.0183898235904972 431 37 5 0.135135135135135 0.0116009280742459
GO:CC GO:0005886 plasma membrane 0.0183898235904972 5681 77 36 0.467532467532468 0.00633691251540222
GO:CC GO:0005796 Golgi lumen 0.0183898235904972 99 40 3 0.075 0.0303030303030303
GO:CC GO:0062023 collagen-containing extracellular matrix 0.0183898235904972 421 96 8 0.0833333333333333 0.0190023752969121
GO:CC GO:0016021 integral component of membrane 0.020460584537066 5711 75 35 0.466666666666667 0.00612852390124321
GO:CC GO:0030141 secretory granule 0.0216129226665367 851 89 11 0.123595505617978 0.0129259694477086
GO:CC GO:0072562 blood microparticle 0.0216129226665367 140 122 5 0.040983606557377 0.0357142857142857
GO:CC GO:0099503 secretory vesicle 0.025921535494416 1020 89 12 0.134831460674157 0.0117647058823529
GO:CC GO:0035578 azurophil granule lumen 0.025921535494416 91 122 4 0.0327868852459016 0.043956043956044
GO:CC GO:0005766 primary lysosome 0.0268843403600839 154 122 5 0.040983606557377 0.0324675324675325
GO:CC GO:0042582 azurophil granule 0.0268843403600839 154 122 5 0.040983606557377 0.0324675324675325
GO:CC GO:0031012 extracellular matrix 0.0275736406976152 562 122 10 0.0819672131147541 0.0177935943060498
GO:CC GO:0030312 external encapsulating structure 0.0275736406976152 563 122 10 0.0819672131147541 0.0177619893428064
GO:CC GO:0016020 membrane 0.0427348031365849 9838 75 50 0.666666666666667 0.00508233380768449
GO:CC GO:0031967 organelle envelope 0.0452806235254215 1237 7 3 0.428571428571429 0.00242522231204527
GO:CC GO:0031975 envelope 0.0452806235254215 1237 7 3 0.428571428571429 0.00242522231204527
GO:CC GO:0055037 recycling endosome 0.0463755848849856 188 42 3 0.0714285714285714 0.0159574468085106
GO:MF GO:0022804 active transmembrane transporter activity 0.00933931135970344 312 103 9 0.087378640776699 0.0288461538461538
GO:MF GO:0015291 secondary active transmembrane transporter activity 0.00933931135970344 237 103 8 0.0776699029126214 0.0337552742616034
GO:MF GO:0009055 electron transfer activity 0.00933931135970344 148 24 4 0.166666666666667 0.027027027027027
GO:MF GO:0005342 organic acid transmembrane transporter activity 0.012507468740033 154 103 6 0.058252427184466 0.038961038961039
GO:MF GO:0015293 symporter activity 0.012507468740033 143 33 4 0.121212121212121 0.027972027972028
GO:MF GO:0046943 carboxylic acid transmembrane transporter activity 0.012507468740033 153 103 6 0.058252427184466 0.0392156862745098
GO:MF GO:0008514 organic anion transmembrane transporter activity 0.0155188382635223 187 33 4 0.121212121212121 0.0213903743315508
GO:MF GO:0015318 inorganic molecular entity transmembrane transporter activity 0.0186384397750536 831 126 15 0.119047619047619 0.0180505415162455
GO:MF GO:0016491 oxidoreductase activity 0.0203997499501201 771 48 8 0.166666666666667 0.0103761348897536
GO:MF GO:0015075 ion transmembrane transporter activity 0.0217265987067303 956 126 15 0.119047619047619 0.0156903765690377
GO:MF GO:0031406 carboxylic acid binding 0.0217265987067303 194 85 5 0.0588235294117647 0.0257731958762887
GO:MF GO:0016651 oxidoreductase activity, acting on NAD(P)H 0.0217265987067303 107 44 3 0.0681818181818182 0.0280373831775701
GO:MF GO:0016757 transferase activity, transferring glycosyl groups 0.0217265987067303 283 32 4 0.125 0.0141342756183746
GO:MF GO:0043177 organic acid binding 0.0217265987067303 120 79 4 0.0506329113924051 0.0333333333333333
GO:MF GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 0.0217265987067303 167 48 4 0.0833333333333333 0.0239520958083832
GO:MF GO:0008509 anion transmembrane transporter activity 0.0217265987067303 464 103 9 0.087378640776699 0.0193965517241379
GO:MF GO:0022857 transmembrane transporter activity 0.0227306606320965 1075 103 14 0.135922330097087 0.0130232558139535
GO:MF GO:0003779 actin binding 0.0293518930591432 448 42 5 0.119047619047619 0.0111607142857143
GO:MF GO:0008324 cation transmembrane transporter activity 0.0315862476924804 639 126 11 0.0873015873015873 0.0172143974960876
GO:MF GO:0008028 monocarboxylic acid transmembrane transporter activity 0.034443256872462 69 91 3 0.032967032967033 0.0434782608695652
GO:MF GO:0016758 transferase activity, transferring hexosyl groups 0.0362391943372414 205 32 3 0.09375 0.0146341463414634
GO:MF GO:0005215 transporter activity 0.0383150658221067 1185 103 14 0.135922330097087 0.0118143459915612
GO:MF GO:0140272 exogenous protein binding 0.0385023674023007 77 89 3 0.0337078651685393 0.038961038961039
GO:MF GO:0001618 virus receptor activity 0.0385023674023007 76 89 3 0.0337078651685393 0.0394736842105263
GO:MF GO:0030971 receptor tyrosine kinase binding 0.039702835855909 72 97 3 0.0309278350515464 0.0416666666666667
GO:MF GO:0000149 SNARE binding 0.0400948247152264 114 125 4 0.032 0.0350877192982456
GO:MF GO:0005506 iron ion binding 0.0400948247152264 155 48 3 0.0625 0.0193548387096774
GO:MF GO:0022853 active ion transmembrane transporter activity 0.0400948247152264 213 103 5 0.0485436893203883 0.0234741784037559
GO:MF GO:0048018 receptor ligand activity 0.0410182392070339 494 16 3 0.1875 0.00607287449392713
GO:MF GO:0030546 signaling receptor activator activity 0.0421896778883389 501 16 3 0.1875 0.00598802395209581
GO:MF GO:0005102 signaling receptor binding 0.0430540922740404 1672 34 8 0.235294117647059 0.00478468899521531
GO:MF GO:0015171 amino acid transmembrane transporter activity 0.0436255447528762 78 103 3 0.029126213592233 0.0384615384615385
GO:MF GO:0030545 receptor regulator activity 0.0473122835672433 545 16 3 0.1875 0.0055045871559633
GO:MF GO:0015297 antiporter activity 0.049072546546592 84 103 3 0.029126213592233 0.0357142857142857
GO:MF GO:0031267 small GTPase binding 0.0493628564601133 298 55 4 0.0727272727272727 0.0134228187919463
HP HP:0000096 Glomerular sclerosis 0.00288980703273808 75 27 6 0.222222222222222 0.08
HP HP:0012766 Widened cerebral subarachnoid space 0.00288980703273808 8 22 3 0.136363636363636 0.375
HP HP:0000097 Focal segmental glomerulosclerosis 0.00288980703273808 45 27 5 0.185185185185185 0.111111111111111
HP HP:0000590 Progressive external ophthalmoplegia 0.00288980703273808 26 22 4 0.181818181818182 0.153846153846154
HP HP:0007327 Mixed demyelinating and axonal polyneuropathy 0.00322964687638822 9 22 3 0.136363636363636 0.333333333333333
HP HP:0005157 Concentric hypertrophic cardiomyopathy 0.00380830316101226 10 22 3 0.136363636363636 0.3
HP HP:0012705 Abnormal metabolic brain imaging by MRS 0.00380830316101226 32 22 4 0.181818181818182 0.125
HP HP:0000576 Centrocecal scotoma 0.00380830316101226 12 22 3 0.136363636363636 0.25
HP HP:0002579 Gastrointestinal dysmotility 0.00380830316101226 71 22 5 0.227272727272727 0.0704225352112676
HP HP:0025268 Stuttering 0.00380830316101226 12 22 3 0.136363636363636 0.25
HP HP:0030895 Abnormal gastrointestinal motility 0.00380830316101226 71 22 5 0.227272727272727 0.0704225352112676
HP HP:0007067 Distal peripheral sensory neuropathy 0.00452381661672951 13 22 3 0.136363636363636 0.230769230769231
HP HP:0001345 Psychotic mentation 0.00491940173624452 14 22 3 0.136363636363636 0.214285714285714
HP HP:0003200 Ragged-red muscle fibers 0.00491940173624452 40 22 4 0.181818181818182 0.1
HP HP:0002401 Stroke-like episode 0.00536351062184159 15 22 3 0.136363636363636 0.2
HP HP:0100027 Recurrent pancreatitis 0.00536351062184159 15 22 3 0.136363636363636 0.2
HP HP:0002922 Increased CSF protein 0.00637432065949691 45 22 4 0.181818181818182 0.0888888888888889
HP HP:0012707 Elevated brain lactate level by MRS 0.006444539539845 17 22 3 0.136363636363636 0.176470588235294
HP HP:0025456 Abnormal CSF protein level 0.006444539539845 47 22 4 0.181818181818182 0.0851063829787234
HP HP:0007159 Fluctuations in consciousness 0.006444539539845 17 22 3 0.136363636363636 0.176470588235294
HP HP:0200125 Mitochondrial respiratory chain defects 0.00662791197226454 18 22 3 0.136363636363636 0.166666666666667
HP HP:0001427 Mitochondrial inheritance 0.00662791197226454 18 22 3 0.136363636363636 0.166666666666667
HP HP:0025045 Abnormal brain lactate level by MRS 0.00662791197226454 18 22 3 0.136363636363636 0.166666666666667
HP HP:0012429 Aplasia/Hypoplasia of the cerebral white matter 0.00694038936754633 19 22 3 0.136363636363636 0.157894736842105
HP HP:0007763 Retinal telangiectasia 0.00694038936754633 19 22 3 0.136363636363636 0.157894736842105
HP HP:0001716 Wolff-Parkinson-White syndrome 0.00694038936754633 19 22 3 0.136363636363636 0.157894736842105
HP HP:0003737 Mitochondrial myopathy 0.00827527304576499 54 22 4 0.181818181818182 0.0740740740740741
HP HP:0000544 External ophthalmoplegia 0.00857789268585934 55 22 4 0.181818181818182 0.0727272727272727
HP HP:0004309 Ventricular preexcitation 0.0108544354260515 23 22 3 0.136363636363636 0.130434782608696
HP HP:0004389 Intestinal pseudo-obstruction 0.0108544354260515 23 22 3 0.136363636363636 0.130434782608696
HP HP:0001045 Vitiligo 0.0135554726404454 25 22 3 0.136363636363636 0.12
HP HP:0002331 Recurrent paroxysmal headache 0.0147975995432149 26 22 3 0.136363636363636 0.115384615384615
HP HP:0031263 Abnormal renal corpuscle morphology 0.0151671158665531 158 27 6 0.222222222222222 0.0379746835443038
HP HP:0000095 Abnormal renal glomerulus morphology 0.0151671158665531 158 27 6 0.222222222222222 0.0379746835443038
HP HP:0100651 Type I diabetes mellitus 0.0151671158665531 45 59 5 0.0847457627118644 0.111111111111111
HP HP:0003800 Muscle abnormality related to mitochondrial dysfunction 0.0161648371710913 69 22 4 0.181818181818182 0.0579710144927536
HP HP:0010794 Impaired visuospatial constructive cognition 0.017815302045818 29 22 3 0.136363636363636 0.103448275862069
HP HP:0007141 Sensorimotor neuropathy 0.0180488159428821 72 22 4 0.181818181818182 0.0555555555555556
HP HP:0004885 Episodic respiratory distress 0.020097745044419 17 40 3 0.075 0.176470588235294
HP HP:0007924 Slow decrease in visual acuity 0.0211017144033802 32 22 3 0.136363636363636 0.09375
HP HP:0000622 Blurred vision 0.0211017144033802 32 22 3 0.136363636363636 0.09375
HP HP:0002572 Episodic vomiting 0.0211017144033802 32 22 3 0.136363636363636 0.09375
HP HP:0007302 Bipolar affective disorder 0.0236104377304793 34 22 3 0.136363636363636 0.0882352941176471
HP HP:0100754 Mania 0.024646579496832 35 22 3 0.136363636363636 0.0857142857142857
HP HP:0002135 Basal ganglia calcification 0.024646579496832 35 22 3 0.136363636363636 0.0857142857142857
HP HP:0011035 Abnormal renal cortex morphology 0.0273297617185436 187 27 6 0.222222222222222 0.0320855614973262
HP HP:0003348 Hyperalaninemia 0.0273297617185436 37 22 3 0.136363636363636 0.0810810810810811
HP HP:0000829 Hypoparathyroidism 0.0273297617185436 37 22 3 0.136363636363636 0.0810810810810811
HP HP:0010916 Abnormal circulating alanine concentration 0.027903944944511 38 22 3 0.136363636363636 0.0789473684210526
HP HP:0008316 Abnormal mitochondria in muscle tissue 0.027903944944511 38 22 3 0.136363636363636 0.0789473684210526
HP HP:0010915 Abnormal circulating pyruvate family amino acid concentration 0.027903944944511 38 22 3 0.136363636363636 0.0789473684210526
HP HP:0002013 Vomiting 0.0324240604975746 264 28 7 0.25 0.0265151515151515
HP HP:0012841 Retinal vascular tortuosity 0.0336558069335071 41 22 3 0.136363636363636 0.0731707317073171
HP HP:0410263 Brain imaging abnormality 0.033680279569236 95 22 4 0.181818181818182 0.0421052631578947
HP HP:0007108 Demyelinating peripheral neuropathy 0.033680279569236 42 22 3 0.136363636363636 0.0714285714285714
HP HP:0000751 Personality changes 0.034439022988095 43 22 3 0.136363636363636 0.0697674418604651
HP HP:0012575 Abnormal nephron morphology 0.0351339615555427 208 27 6 0.222222222222222 0.0288461538461538
HP HP:0000603 Central scotoma 0.0357783761247396 45 22 3 0.136363636363636 0.0666666666666667
HP HP:0033108 Abnormal circulating proteinogenic amino acid derivative concentration 0.0400365095998552 47 22 3 0.136363636363636 0.0638297872340425
HP HP:0000114 Proximal tubulopathy 0.0419620484289793 48 22 3 0.136363636363636 0.0625
REAC REAC:R-HSA-1430728 Metabolism 0.021929797958275 2070 40 19 0.475 0.00917874396135266
REAC REAC:R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 0.0255551690552379 174 7 3 0.428571428571429 0.0172413793103448
REAC REAC:R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.0432815431605973 67 38 3 0.0789473684210526 0.0447761194029851
REAC REAC:R-HSA-3781865 Diseases of glycosylation 0.0432815431605973 140 40 4 0.1 0.0285714285714286
REAC REAC:R-HSA-1222556 ROS and RNS production in phagocytes 0.0432815431605973 36 72 3 0.0416666666666667 0.0833333333333333
REAC REAC:R-HSA-611105 Respiratory electron transport 0.0432815431605973 100 22 3 0.136363636363636 0.03

pEpiTp32 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp32
Possible regulators of activation of pEpiTp32 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.